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101. Extended analysis of parent and child confidence in recognizing anaphylaxis and using the epinephrine autoinjector during oral food challenges

Author: Ingrid Baerg, Edmond S. Chan, Tiffany Wong, Timothy Teoh, Kyla J. Hildebrand, Scott B. Cameron, Catherine M. Biggs, Lianne Soller, Nicole J. Lee, Victoria E. Cook, and Lindsay Yaworski
Subjects: Male, Parents, medicine.medical_specialty, Health Knowledge, Attitudes, Practice, Epinephrine, business.industry, medicine.disease, Injections, Intramuscular, Self Concept, Bronchodilator Agents, Legal Guardians, Equipment and Supplies, Patient Education as Topic, Child, Preschool, Emergency medicine, medicine, Immunology and Allergy, Humans, Epinephrine autoinjector, Female, business, Child, Anaphylaxis
Published: 2018

102. The Importance of Delabeling β-Lactam Allergy in Children

Author: Elissa M. Abrams, Moshe Ben-Shoshan, Adelle Atkinson, and Tiffany Wong
Subjects: Male, business.industry, Drug allergy, Infant, Penicillin allergy, Exanthema, Immunologic Tests, medicine.disease, beta-Lactams, Anti-Bacterial Agents, Diagnosis, Differential, Drug Hypersensitivity, Pediatrics, Perinatology and Child Health, Immunology, Medicine, Humans, β lactam allergy, Diagnostic Errors, business, Child
Published: 2018

103. The home hemodialysis patient experience: A qualitative assessment of modality use and discontinuation

Author: Joel D. Glickman, Judy A. Shea, Tiffany Wong, Rebecca Kurnik Seshasai, and Laura M. Dember
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, 030232 urology & nephrology, Hemodialysis, Home, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Respite care, Patient experience, Interview, Psychological, medicine, Humans, Longitudinal Studies, Medical prescription, business.industry, Home hemodialysis, Flexibility (personality), Hematology, Caregiver burden, Middle Aged, United States, Discontinuation, Nephrology, Family medicine, Kidney Failure, Chronic, Female, Hemodialysis, business
Abstract: Introduction Home hemodialysis (HHD) is an under-utilized renal replacement modality in the United States in part because of high rates of discontinuation and transfer to in-center hemodialysis. Understanding, from the perspective of patients, facilitators, and barriers to sustained use of HHD is important for increasing successful use of this modality. Methods We conducted 25 semistructured interviews with 15 current and 10 former adult patients treated with home hemodialysis (23 short daily HHD and 2 nocturnal HHD). Interview transcripts were audiotaped, transcribed verbatim, and thematically analyzed. Findings Five themes related to continuation or discontinuation of HHD emerged: (1) degree of independence (increased flexibility, burden of therapy), (2) availability of support (emotional and physical support and caregiver burden), (3) technical aspects (familiarity with machine), (4) home environment (ability to organize supplies, space in home), and (5) attitude and expectations (positive or negative outlook about performing HHD). For each theme, positive aspects facilitated continuation of HHD and negative aspects contributed to discontinuation of HHD. Discussion HHD can be burdensome to patients and family members, and some discontinuations may be preventable. Helping patients with scheduling and organization, improving communication about expectations and trouble-shooting, supporting patients as well as family members, adapting the dialysis prescription to the patient's lifestyle when possible, and providing respite when needed may make HHD more sustainable for patients.
Published: 2018

104. Study of muons from ultrahigh energy cosmic ray air showers measured with the Telescope Array experiment

Author: S. Kitamura, Hidemi Ito, Kenta Yashiro, Eiji Kido, M. V. Kuznetsov, Kazuhiro Machida, Jyunsei Chiba, Dongsu Ryu, Y. Takagi, Douglas Bergman, Toshiyuki Nonaka, K. Nagasawa, Hideki Tanaka, Elliott Barcikowski, J. H. Kim, T. Goto, G. Furlich, Takaaki Ishii, Y. Omura, Keitaro Fujita, Dmitri Ivanov, Pierre Sokolsky, J. Ogura, Yasunori Saito, B. K. Shin, Igor Tkachev, D. C. Rodriguez, R. Sahara, M. Takeda, Shigehiro Nagataki, Keijiro Mukai, Yuichiro Tameda, John N. Matthews, Akimichi Taketa, Rasha Abbasi, H. Oda, K. Yamazaki, M. Yamamoto, L. M. Scott, Nobuyuki Sakurai, T. Suzawa, Y. Yoneda, N. Inoue, M. Ohnishi, Sergey Troitsky, J. Remington, Y. Hayashi, Inkyu Park, Federico R. Urban, S. Udo, C. C. H. Jui, Isaac Myers, Y. J. Kwon, Hideyuki Ohoka, K. Kawata, Ryota Onogi, Koichi Sekino, A. Di Matteo, K. H. Lee, S. B. Thomas, T.-A. Shibata, Naoaki Hayashida, Takayuki Tomida, Gordon Thomson, T. Matsuyama, S. Ozawa, R. Mayta, Hongsu Kim, Priti Shah, Tom Stroman, Robert Cady, Y. Zhezher, Grigory Rubtsov, Hideaki Shimodaira, Hyoming Jeong, Y. Takahashi, Mai Takamura, K. Kasahara, Y. Uchihori, Shoichi Kishigami, S. Yoshida, Naoto Sakaki, R. Azuma, Masaomi Ono, Tareq Abu-Zayyad, R. Yamane, Kiyoshi Tanaka, Motoki Hayashi, J. P. Lundquist, Shingo Kawana, William Hanlon, M. Allen, H. Kawai, T. Okuda, J. Yang, H. Tokuno, J. D. Smith, Daisuke Ikeda, S. R. Stratton, Tiffany Wong, R. Takeishi, T. Seki, Masaki Fukushima, Masato Takita, K. Martens, K. Tsutsumi, Peter Tinyakov, Samuel Blake, Shoichi Ogio, Zach Zundel, Fumiya Shibata, R. Ishimori, Toshitsugu Fujii, Oleg Kalashev, H. Yamaoka, Michiyuki Chikawa, Ryo Nakamura, Kazuo Saito, H. Yoshii, Heungsu Shin, Toru Nakamura, K. Hibino, Kenichi Kadota, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, K. Honda, Yasunori Kitamura, Masaaki Tanaka, John Belz, Hiroyuki Sagawa, Ben Stokes, B. G. Cheon, S. Kawakami, Maxim Pshirkov, Akitoshi Oshima, Y. Tsunesada, M. Abe, Fumio Kakimoto, Vladim Kuzmin, and S. Jeong
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Muon, COSMIC cancer database, Particle number, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Monte Carlo method, Hadron, FOS: Physical sciences, Cosmic ray, 01 natural sciences, law.invention, Telescope, Nuclear physics, Air shower, 13. Climate action, law, 0103 physical sciences, High Energy Physics::Experiment, Astrophysics - High Energy Astrophysical Phenomena, 010306 general physics
Abstract: One of the uncertainties in interpretation of ultra-high energy cosmic ray (UHECR) data comes from the hadronic interaction models used for air shower Monte Carlo (MC) simulations. The number of muons observed at the ground from UHECR-induced air showers is expected to depend upon the hadronic interaction model. One may therefore test the hadronic interaction models by comparing the measured number of muons with the MC prediction. In this paper, we present the results of studies of muon densities in UHE extensive air showers obtained by analyzing the signal of surface detector stations which should have high $\it{muon \, purity}$. The muon purity of a station will depend on both the inclination of the shower and the relative position of the station. In 7 years' data from the Telescope Array experiment, we find that the number of particles observed for signals with an expected muon purity of $\sim$65% at a lateral distance of 2000 m from the shower core is $1.72 \pm 0.10{\rm (stat.)} \pm 0.37 {\rm (syst.)}$ times larger than the MC prediction value using the QGSJET II-03 model for proton-induced showers. A similar effect is also seen in comparisons with other hadronic models such as QGSJET II-04, which shows a $1.67 \pm 0.10 \pm 0.36$ excess. We also studied the dependence of these excesses on lateral distances and found a slower decrease of the lateral distribution of muons in the data as compared to the MC, causing larger discrepancy at larger lateral distances.
Published: 2018

105. Identification of Ca

Author: Man Kit, Tse, Ting Shing, Hung, Ching Man, Chan, Tiffany, Wong, Mike, Dorothea, Catherine, Leclerc, Marc, Moreau, Andrew L, Miller, and Sarah E, Webb
Subjects: Neurons, Neural Stem Cells, Animals, Gene Expression Regulation, Developmental, Cell Differentiation, Neurodegenerative Diseases, Calcium Signaling, Neuroglia, Cells, Cultured, Zebrafish, Signal Transduction
Abstract: The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells (NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor (IP
Published: 2018

106. Depth of Ultra High Energy Cosmic Ray Induced Air Shower Maxima Measured by the Telescope Array Black Rock and Long Ridge FADC Fluorescence Detectors and Surface Array in Hybrid Mode

Author: R. Azuma, M. Yamamoto, Nobuyuki Sakurai, Ryota Onogi, A. Di Matteo, R. Mayta, B. G. Cheon, Fumiya Shibata, K. Martens, Hideki Tanaka, R. Ishimori, K. H. Lee, M. Abe, T.-A. Shibata, Gordon Thomson, Tom Stroman, Robert Cady, H. Tokuno, S. Kitamura, Priti Shah, T. Goto, K. Tsutsumi, Hideaki Shimodaira, Hyoming Jeong, Rasha Abbasi, S. Kawakami, Akimichi Taketa, Hidemi Ito, Jyunsei Chiba, Dongsu Ryu, J. D. Smith, J. Ogura, Toshiyuki Nonaka, Kiyoshi Tanaka, Akitoshi Oshima, Y. Takagi, G. Furlich, Takaaki Ishii, Shunsuke Ozawa, O. Kalashev, BayarJon Paul Lubsandorzhiev, Hiroshi Yamaoka, Mayuko Minamino, K. Honda, Y. Zhezher, Hiroyuki Sagawa, Keitaro Fujita, Yasunori Kitamura, Peter Tinyakov, Samuel Blake, D. C. Rodriguez, Shoichi Ogio, Ben Stokes, Toshitsugu Fujii, T. Matsuyama, Elliott Barcikowski, B. K. Shin, K. Yamazaki, Dmitri Ivanov, T. Suzawa, M. Allen, Masaaki Tanaka, K. Hibino, R. Sahara, Heungsu Shin, Zach Zundel, Ryo Nakamura, Keijiro Mukai, Isaac Myers, Kazuo Saito, Inkyu Park, Hongsu Kim, Pierre Sokolsky, S. Yoshida, Eiji Kido, Naoto Sakaki, Grigory Rubtsov, M. V. Kuznetsov, M. Takeda, John Belz, Vladim Kuzmin, H. Yoshii, Kazuhiro Machida, Shigehiro Nagataki, S. Jeong, Michiyuki Chikawa, H. Kawai, Tareq Abu-Zayyad, R. Yamane, K. Nagasawa, Douglas Bergman, Y. J. Kwon, Hideyuki Ohoka, Yasunori Saito, T. Seki, Yoshiki Tsunesada, Daisuke Ikeda, S. R. Stratton, Y. Uchihori, L. M. Scott, Tiffany Wong, R. Takeishi, Masaki Fukushima, Toru Nakamura, Y. Hayashi, Yuichiro Tameda, K. Kawata, John N. Matthews, Masato Takita, Kenichi Kadota, Sergey Troitsky, J. H. Kim, Y. Omura, Shingo Kawana, Naoaki Hayashida, William Hanlon, Igor Tkachev, T. Okuda, J. Yang, H. Oda, Kenta Yashiro, Y. Yoneda, N. Inoue, M. Ohnishi, Federico R. Urban, S. Udo, C. C. H. Jui, S. B. Thomas, Takayuki Tomida, K. Kasahara, Shoichi Kishigami, Masaomi Ono, Maxim Pshirkov, Motoki Hayashi, J. P. Lundquist, Koichi Sekino, Y. Takahashi, Mai Takamura, and Fumio Kakimoto
Subjects: Astrophysics::High Energy Astrophysical Phenomena, chemistry.chemical_element, FOS: Physical sciences, Cosmic ray, 7. Clean energy, 01 natural sciences, law.invention, Telescope, Optics, Observatory, law, 0103 physical sciences, Ultra-high-energy cosmic ray, 010303 astronomy & astrophysics, Helium, Astroparticle physics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, business.industry, Astronomy and Astrophysics, Air shower, chemistry, 13. Climate action, Space and Planetary Science, Ridge (meteorology), Astrophysics - High Energy Astrophysical Phenomena, business
Abstract: The Telescope Array observatory utilizes fluorescence detectors and surface detectors to observe air showers produced by ultra high energy cosmic rays in the Earth's atmosphere. Cosmic ray events observed in this way are termed hybrid data. The depth of air shower maximum is related to the mass of the primary particle that generates the shower. This paper reports on shower maxima data collected over 8.5 years using the Black Rock Mesa and Long Ridge fluorescence detectors in conjunction with the array of surface detectors. We compare the means and standard deviations of the observed $X_{\mathrm{max}}$ distributions with Monte Carlo $X_{\mathrm{max}}$ distributions of unmixed protons, helium, nitrogen, and iron, all generated using the QGSJet~II-04 hadronic model. We also perform an unbinned maximum likelihood test of the observed data, which is subjected to variable systematic shifting of the data $X_{\mathrm{max}}$ distributions to allow us to test the full distributions, and compare them to the Monte Carlo to see which elements are not compatible with the observed data. For all energy bins, QGSJet~II-04 protons are found to be compatible with Telescope Array hybrid data at the 95% confidence level after some systematic $X_{\mathrm{max}}$ shifting of the data. Three other QGSJet~II-04 elements are found to be compatible using the same test procedure in an energy range limited to the highest energies where data statistics are sparse., Comment: 39 pages, 18 figures, 5 tables, published in The Astrophysical Journal. This is a peer-reviewed, un-copyedited version of an article published in The Astrophysical Journal. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.3847/1538-4357/aabad7
Published: 2018
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107. Evidence of Intermediate-Scale Energy Spectrum Anisotropy of Cosmic Rays E$\geq$10$^{19.2}$ eV with the Telescope Array Surface Detector

Author: N. Inoue, M. Ohnishi, R. Sahara, Toru Nakamura, S. Udo, Kenichi Kadota, Maxim Pshirkov, K. Kasahara, M. Abe, Shoichi Kishigami, T. Goto, Toshiyuki Nonaka, Zach Zundel, S. B. Thomas, Fumio Kakimoto, Masaomi Ono, Jyunsei Chiba, Charlie Jui, Dongsu Ryu, B. K. Shin, Hiroshi Yamaoka, Yoshiki Tsunesada, Daisuke Ikeda, Kenta Yashiro, Keitaro Fujita, BayarJon Paul Lubsandorzhiev, Ben Stokes, S. R. Stratton, Y. Takagi, Tiffany Wong, Mayuko Minamino, K. Honda, Masaki Fukushima, H. Tokuno, Yasunori Kitamura, K. Martens, Masato Takita, Hideki Tanaka, Takayuki Tomida, Masaaki Tanaka, J. D. Smith, Fumiya Shibata, Sergey Troitsky, S. Kitamura, R. Ishimori, Keiji Saito, Igor Tkachev, Michiyuki Chikawa, Eiji Kido, M. V. Kuznetsov, D. R. Bergman, H. Oda, Kazuhiro Machida, Hidemi Ito, Pierre Sokolsky, Y. Uchihori, Y. J. Kwon, Hideyuki Ohoka, R. Takeishi, Yasunori Saito, Shigehiro Nagataki, Akitoshi Oshima, T. Matsuyama, Yana Zhezher, T. Suzawa, Shunsuke Ozawa, Shingo Kawana, Yuichiro Tameda, John N. Matthews, Priti Shah, O. Kalashev, Vladim Kuzmin, William Hanlon, J. Ogura, F. Urban, S. Jeong, Isaac Myers, Motoki Hayashi, Peter Tinyakov, J. P. Lundquist, Samuel Blake, Shoichi Ogio, T. Okuda, J. Yang, M. Allen, Y. Omura, Naoaki Hayashida, Koichi Sekino, Elliott Barcikowski, K. Nagasawa, Dmitri Ivanov, Y. Takahashi, Mai Takamura, G. Furlich, Takaaki Ishii, Keijiro Mukai, D. C. Rodriguez, S. Yoshida, Naoto Sakaki, Rasha Abbasi, Kiyoshi Tanaka, John Belz, R. Azuma, Inkyu Park, L. M. Scott, A. Nozato, Y. Hayashi, K. Kawata, Hideaki Shimodaira, Hyoming Jeong, K. H. Lee, Tareq Abu-Zayyad, Hiroyuki Sagawa, T.-A. Shibata, R. Yamane, Gordon Thomson, Ryo Nakamura, Tom Stroman, Robert Cady, Hongsu Kim, Akimichi Taketa, Grigory Rubtsov, M. Yamamoto, H. Yoshii, Nobuyuki Sakurai, K. Yamazaki, Takahiro Fujii, Ryota Onogi, J. H. Kim, A. Di Matteo, B. G. Cheon, R. Mayta, K. Hibino, S. Kawakami, Heungsu Shin, K. Tsutsumi, H. Kawai, T. Seki, and Y. Yoneda
Subjects: Astroparticle physics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, Detector, Monte Carlo method, Isotropy, FOS: Physical sciences, Astronomy and Astrophysics, Cosmic ray, Astrophysics, Poisson distribution, 01 natural sciences, law.invention, Telescope, symbols.namesake, Space and Planetary Science, law, 0103 physical sciences, symbols, Anisotropy, Astrophysics - High Energy Astrophysical Phenomena, 010303 astronomy & astrophysics
Abstract: An intermediate-scale energy spectrum anisotropy has been found in the arrival directions of ultra-high energy cosmic rays of energies above $10^{19.2}$ eV in the northern hemisphere, using 7 years of data from the Telescope Array surface detector. A relative energy distribution test is done comparing events inside oversampled spherical caps of equal exposure, to those outside, using the Poisson likelihood ratio. The center of maximum significance is at $9^h$$16^m$, $45^{\circ}$. and has a deficit of events with energies $10^{19.2}$$\leq$$E$$
Published: 2018
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108. Constraints on the diffuse photon flux with energies above $10^{18}$ eV using the surface detector of the Telescope Array experiment

Author: Rasha Abbasi, Fumiya Shibata, S. Yoshida, T. Matsuyama, S. Ozawa, Naoto Sakaki, Yasunori Saito, John Belz, K. Nagasawa, R. Ishimori, S. Kitamura, Hidemi Ito, Ryo Nakamura, Motoki Hayashi, Toshiyuki Nonaka, Hideki Tanaka, Kazuo Saito, J. P. Lundquist, M. Yamamoto, Ben Stokes, B. G. Cheon, Heungsu Shin, T. Suzawa, Yuichiro Tameda, Isaac Myers, Inkyu Park, John N. Matthews, Douglas Bergman, Nobuyuki Sakurai, Ryota Onogi, A. Di Matteo, Koichi Sekino, M. Allen, R. Mayta, Y. Zhezher, Grigory Rubtsov, Kenta Yashiro, K. Martens, K. Tsutsumi, Keitaro Fujita, Y. Takahashi, Mai Takamura, L. M. Scott, H. Yoshii, Daisuke Ikeda, Eiji Kido, M. V. Kuznetsov, S. Kawakami, Y. Uchihori, R. Azuma, Toshitsugu Fujii, Kazuhiro Machida, S. R. Stratton, Y. Hayashi, Sergey Troitsky, B. K. Shin, Oleg Kalashev, Hongsu Kim, Hiroyuki Sagawa, Tiffany Wong, R. Takeishi, Charlie Jui, J. Remington, Pierre Sokolsky, K. Kawata, Masaki Fukushima, Akimichi Taketa, G. Furlich, Takaaki Ishii, J. H. Kim, BayarJon Paul Lubsandorzhiev, M. Takeda, Shigehiro Nagataki, Mayuko Minamino, Hideaki Shimodaira, Hyoming Jeong, D. C. Rodriguez, H. Kawai, Y. Omura, Kiyoshi Tanaka, K. Kasahara, K. Honda, Akitoshi Oshima, Y. Tsunesada, Shoichi Kishigami, Yasunori Kitamura, Naoaki Hayashida, Masaaki Tanaka, T. Seki, Masato Takita, J. Ogura, H. Yamaoka, Masaomi Ono, R. Sahara, Michiyuki Chikawa, Y. Yoneda, N. Inoue, Jyunsei Chiba, K. Hibino, Shingo Kawana, Fumio Kakimoto, Dongsu Ryu, K. Yamazaki, Tareq Abu-Zayyad, R. Yamane, Maksim Piskunov, William Hanlon, M. Ohnishi, Takayuki Tomida, Y. Takagi, T. Okuda, J. Yang, Federico R. Urban, Toru Nakamura, S. Udo, K. H. Lee, Kenichi Kadota, T.-A. Shibata, H. Tokuno, Zach Zundel, J. D. Smith, Priti Shah, Gordon Thomson, S. B. Thomas, Tom Stroman, Robert Cady, Igor Tkachev, Maxim Pshirkov, Elliott Barcikowski, Dmitri Ivanov, H. Oda, Keijiro Mukai, Peter Tinyakov, Samuel Blake, Shoichi Ogio, Vladim Kuzmin, T. Goto, S. Jeong, M. Abe, Y. J. Kwon, and Hideyuki Ohoka
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Muon, Photon, 010308 nuclear & particles physics, Detector, FOS: Physical sciences, Astronomy and Astrophysics, Curvature, 01 natural sciences, Computational physics, law.invention, High Energy Physics - Experiment, Telescope, High Energy Physics - Phenomenology, High Energy Physics - Experiment (hep-ex), Air shower, Distribution function, High Energy Physics - Phenomenology (hep-ph), law, 0103 physical sciences, Waveform, Astrophysics - High Energy Astrophysical Phenomena, 010303 astronomy & astrophysics
Abstract: We present the results of the search for ultra-high-energy photons with nine years of data from the Telescope Array surface detector. A multivariate classifier is built upon 16 reconstructed parameters of the extensive air shower. These parameters are related to the curvature and the width of the shower front, the steepness of the lateral distribution function, and the timing parameters of the waveforms sensitive to the shower muon content. A total number of two photon candidates found in the search is fully compatible with the expected background. The $95\%\,$CL limits on the diffuse flux of the photons with energies greater than $10^{18.0}$, $10^{18.5}$, $10^{19.0}$, $10^{19.5}$ and $10^{20.0}$ eV are set at the level of $0.067$, $0.012$, $0.0036$, $0.0013$, $0.0013~\mbox{km}^{-2}\mbox{yr}^{-1}\mbox{sr}^{-1}$ correspondingly., Comment: 7 pages, 2 figures
Published: 2018
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109. Mass composition of ultra-high-energy cosmic rays with the Telescope Array Surface Detector Data

Author: J. Remington, Koichi Sekino, S. Kitamura, Hidemi Ito, M. Yamamoto, Nobuyuki Sakurai, Ryota Onogi, A. Di Matteo, R. Mayta, Naoaki Hayashida, J. H. Kim, H. Tokuno, B. G. Cheon, Y. Takahashi, Mai Takamura, Pierre Sokolsky, Y. Omura, T. Suzawa, J. D. Smith, S. Yoshida, Naoto Sakaki, M. Takeda, Shigehiro Nagataki, T. Goto, Douglas Bergman, K. Nagasawa, Toshitsugu Fujii, K. Hibino, R. Azuma, Takayuki Tomida, BayarJon Paul Lubsandorzhiev, Kenta Yashiro, Yasunori Saito, Ryo Nakamura, Mayuko Minamino, K. Honda, Isaac Myers, Yasunori Kitamura, S. Kawakami, Kazuo Saito, O. Kalashev, K. Tsutsumi, Fumio Kakimoto, John Belz, Yuichiro Tameda, John N. Matthews, K. Martens, Toru Nakamura, Grigory Rubtsov, Maxim S. Piskunov, H. Yoshii, Masaaki Tanaka, Priti Shah, Fumiya Shibata, R. Ishimori, Kenichi Kadota, Hideki Tanaka, T. Matsuyama, L. M. Scott, Michiyuki Chikawa, K. Yamazaki, Hiroyuki Sagawa, Kohei Yada, Y. Hayashi, Shingo Kawana, R. Sahara, K. H. Lee, T.-A. Shibata, Gordon Thomson, Tom Stroman, Robert Cady, Y. J. Kwon, Hideyuki Ohoka, Elliott Barcikowski, Toshiyuki Nonaka, Dmitri Ivanov, Motoki Hayashi, M. Allen, K. Kawata, S. Ozawa, William Hanlon, J. P. Lundquist, Jyunsei Chiba, Dongsu Ryu, K. Kasahara, Shoichi Kishigami, Daisuke Ikeda, Keijiro Mukai, S. R. Stratton, G. Furlich, Takaaki Ishii, Hiroshi Yamaoka, Keitaro Fujita, Masato Takita, T. Okuda, J. Yang, Hongsu Kim, Masaomi Ono, B. K. Shin, Hideaki Shimodaira, Hyoming Jeong, Tiffany Wong, R. Takeishi, Heungsu Shin, Inkyu Park, Masaki Fukushima, Maxim Pshirkov, D. C. Rodriguez, Akimichi Taketa, Y. Takagi, Eiji Kido, Rasha Abbasi, M. V. Kuznetsov, Kazuhiro Machida, Kiyoshi Tanaka, H. Kawai, Igor Tkachev, J. Ogura, Tareq Abu-Zayyad, R. Yamane, Vladim Kuzmin, T. Seki, S. Jeong, Zach Zundel, Yana Zhezher, Peter Tinyakov, Samuel Blake, Shoichi Ogio, Y. Uchihori, H. Oda, Ben Stokes, M. Abe, Y. Yoneda, N. Inoue, M. Ohnishi, Federico R. Urban, Akitoshi Oshima, Y. Tsunesada, S. Udo, C. C. H. Jui, S. B. Thomas, and Sergey Troitsky
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Library science, FOS: Physical sciences, Mass composition, 01 natural sciences, Promotion (rank), State (polity), Work (electrical), George (robot), 0103 physical sciences, Science policy, High Energy Physics::Experiment, Ultrahigh energy, 010306 general physics, Astrophysics - High Energy Astrophysical Phenomena, Administration (government), media_common
Abstract: The results on ultra-high-energy cosmic rays (UHECR) mass composition obtained with the Telescope Array surface detector are presented. The analysis employs the boosted decision tree (BDT) multivariate analysis built upon 14 observables related to both the properties of the shower front and the lateral distribution function. The multivariate classifier is trained with Monte-Carlo sets of events induced by the primary protons and iron. An average atomic mass of UHECR is presented for energies $10^{18.0}-10^{20.0}\ \mbox{eV}$. The average atomic mass of primary particles shows no significant energy dependence and corresponds to $\langle \ln A \rangle = 2.0 \pm 0.1 (stat.) \pm 0.44 (syst.)$. The result is compared to the mass composition obtained by the Telescope Array with $\mbox{X}_{\mbox{max}}$ technique along with the results of other experiments. Possible systematic errors of the method are discussed., Comment: 11 pages, 9 figures
Published: 2018
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110. Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs

Author: Randall L. Halcomb, Amanda Valdiosera, David Y. Jackson, Lawrence Chinn, Jonathan S. Melnick, Migone Thi Sau, Mark R. Flory, Derrick Houser, Edward H. van der Horst, Maureen Fitch-Bruhns, Simeon Bowers, Edward Ha, Jorge Monteon, Jan Willem Theunissen, Gary Probst, Tiffany Wong, Paul W. Sauer, Zoia Levashova, Kristy Venstrom, Abel Bermudez, Sindy Liao-Chan, and Christopher R. Behrens
Subjects: Male, Antibody-drug conjugate, Immunoconjugates, Lung Neoplasms, Receptor, ErbB-2, Stereochemistry, Blotting, Western, Fluorescent Antibody Technique, Pharmaceutical Science, Antineoplastic Agents, Apoptosis, Fusion Regulatory Protein-1, Mice, SCID, Conjugated system, Article, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, Mice, Inbred NOD, In vivo, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Cysteine, Bifunctional, Maleimide, Cell Proliferation, Chemistry, dBm, Antibodies, Monoclonal, Trastuzumab, Flow Cytometry, Xenograft Model Antitumor Assays, Combinatorial chemistry, Rats, body regions, Cross-Linking Reagents, Molecular Medicine, Female, Linker, Conjugate
Abstract: Conventional antibody–drug conjugates (ADCs) are heterogeneous mixtures of chemically distinct molecules that vary in both drugs/antibody (DAR) and conjugation sites. Suboptimal properties of heterogeneous ADCs have led to new site-specific conjugation methods for improving ADC homogeneity. Most site-specific methods require extensive antibody engineering to identify optimal conjugation sites and introduce unique functional groups for conjugation with appropriately modified linkers. Alternative nonrecombinant methods have emerged in which bifunctional linkers are utilized to cross-link antibody interchain cysteines and afford ADCs containing four drugs/antibody. Although these methods have been shown to improve ADC homogeneity and stability in vitro, their effect on the pharmacological properties of ADCs in vivo is unknown. In order to determine the relative impact of interchain cysteine cross-linking on the therapeutic window and other properties of ADCs in vivo, we synthesized a derivative of the known ADC payload, MC-MMAF, that contains a bifunctional dibromomaleimide (DBM) linker instead of a conventional maleimide (MC) linker. The DBM-MMAF derivative was conjugated to trastuzumab and a novel anti-CD98 antibody to afford ADCs containing predominantly four drugs/antibody. The pharmacological properties of the resulting cross-linked ADCs were compared with analogous heterogeneous ADCs derived from conventional linkers. The results demonstrate that DBM linkers can be applied directly to native antibodies, without antibody engineering, to yield highly homogeneous ADCs via cysteine cross-linking. The resulting ADCs demonstrate improved pharmacokinetics, superior efficacy, and reduced toxicity in vivo compared to analogous conventional heterogeneous ADCs.
Published: 2015

111. Combined Autoimmune Cytopenias Presenting in Childhood

Author: Victoria Price, Nicola A.M. Wright, Ashley Warias, Kelly Cox, Colleen O'Connell, Ibrahim Al Ghaithi, Vicky R. Breakey, and Tiffany Wong
Subjects: Pediatrics, medicine.medical_specialty, Evans syndrome, business.industry, Hematology, Immune dysregulation, medicine.disease, medicine.disease_cause, Thrombocytopenic purpura, Autoimmunity, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Autoimmune neutropenia, Autoimmune lymphoproliferative syndrome, Pediatrics, Perinatology and Child Health, Immunology, medicine, Autoimmune hemolytic anemia, business, Immunodeficiency, 030215 immunology
Abstract: Background Pediatric patients with chronic and/or refractory autoimmune multi-lineage cytopenias present challenges in both diagnosis and management. Increasing availability of diagnostic testing has revealed an underlying immune dysfunction in patients previously diagnosed with Evans Syndrome. However, the data are sparse and the majority of patients are adults. Procedure We performed a retrospective chart review to document the natural history of 23 pediatric patients with autoimmune multi-lineage cytopenias followed at three tertiary care pediatric hematology clinics. Results Investigations revealed seven patients (30.4%) with an autoimmune lymphoproliferative-like syndrome and six patients (26.1%) with other primary immunodeficiencies. Only one (4.3%) patient was suspected to have systemic lupus erythematosus and six patients (26.1%) had other types of autoimmunity. Treatment consisted of immunosuppressive therapy, intravenous gammaglobulin, and splenectomy. Supportive care included granulocyte-colony stimulating factor, and blood product transfusions. Two patients (8.7%) died. Complete remission was achieved in 3 patients (13.0%); of the remaining, 14 patients (60.9%) had chronic immune thrombocytopenic purpura, 10 patients (43.5%) chronic autoimmune neutropenia, and 4 patients (17.4%) chronic autoimmune hemolytic anemia with a median follow up of 5 years (2 months–12 years). Conclusions These data suggest that pediatric patients presenting with autoimmune multi-lineage cytopenias should undergo investigation for underlying immune dysregulation, including autoimmune lymphoproliferative syndrome, other primary immunodeficiencies and autoimmune disorders. The development of an international registry for such patients is imperative to improve the understanding of their complex natural history. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Published: 2015

112. Drosophila Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution

Author: Raechel Harnoto, Morgan C. Anderson, Amy Z. Xu, Heather Hedeen, Arnaldo J. Santiago-Sanabria, Brandy L. Hammond, Kenneth Saville, Ross D. Kooienga, Christopher Chesley, Robert W. Morris, Aubree T. Gillis, Brittney Offenbacker, Katherine C. Palozola, Trisha Tomkins, Nicole Yu, Matthew Kwong, Megan E. Aldrup, Jordan E. Kus, Chelsey Friedrichs, Kenneth Stapleton, Carly E. Pelchen, Norma Chamma, Joshua F. Machone, Danielle Kulich, Andre Kennedy, Matt J. Crowley, Daniel Broomfield, Adeola Adebayo, Nicolas Ragland, Shady Messiah, Jonathan Misch, Meghan B. Rooney, Eva N. Rubio-Marrero, Will Sherrill, Joyce Stamm, Rachel R. Leads, Lindsey Shantzer, Alexis J. Scott, Andrew W. Waggoner, Kristen M. Cooper, Adam Haberman, Carmen A. Watchinski, Marcos A. Perez, Lisa Kadlec, Kiara N. Medina-Ortega, Kayla Chapman, Cheryl Bailey, Nicholas Fazzio, Insun Chong, Lasse Schmidt, Darla M. Balthaser, Megan DeShetler, Jien Shim, Anna Rogers, Chris Uitvlugt, Bryan Yarrington, Ruth A. Howe, Andrea Ochoa, Gregory J. Mullen, Young Lu Kim, Olivia L Knowles, Kevin M. Levine, Matthew M. Villerot, Thomas J. Rose, Jonathan E. Smith, Sukhjit Kaur, Roshni Patel, Olivia Plante, Tenzin Choeying, Jennifer R. Ramthun, Tiffany Y. Y. Choi, Michael Rahimi, Guzal Khayrullina, Lauren R. Boudreaux, James E. J. Bedard, Brian A. Dow, Christopher A. Louie, Kenneth S. Smith, Joannee Zumkehr, Marcus Gostelow, Melissa A. Tache, Tiffany Dai, Joan D. Zambrana-Burgos, Lauren R. Meyer, Carter Brown, Adam Brown, Travis Lamb, Carissa Belella, Hannah Gilman, David DuPuis, Ramón E. Rivera-Vicéns, Priyanka Naik, Anna L. Shipman, Jad El-Adaimi, Eric Spencer, Jonathan D. Marra, Melissa D. Patao, Sharon Ibarra, Jiayu Zhang, Ashley Vetor, Bobbi Botsford, Jenifer Winters, Nelson A. Valentín-Feliciano, Lauren M. Robinson, Christopher R. Macchi, Jennifer Hernández-Muñiz, E. Gloria C. Regisford, Jaelyn L. Johnson, Cory M. Dauphin, Tezin A. Walji, Matthew A. Zaborowicz, Stacey Winkler, Shannon M. Lowell, Marly R. McCracken, Andrew Adams, Lindsay A. Spaeder, Matthew W. Wolski, Adrese Kandahari, Fabiola Robles-Juarbe, Bryce A. Turner, Ángel L. Laboy-Corales, David T. Watson, Elaine J. Durchholz, Vanessa Rodriguez, Emily J. Teepe, Alaina C. Conturso, Eric Nyabeta Onsarigo, Tijana Martinov, Rohit Venkat, Charles R. Hauser, Priya Srikanth, Marwan Ibrahem, Karl E. Smith, Jessica M. Tucci, Ethan J. Brock, Aparna Sreenivasan, Jasmine Hales, Brianna K. Barnard, Andrew P. Stein, Jessica G. Thomas, Mallory Perella, Lorraine Rodriguez-Bonilla, Shekerah Primus, Zachary D. Moore, Caitlin M. Ament, Amber N. Hare, Brad Pamnani, Eugenia A. Soliterman, Christina Paluskievicz, Yashira M. Valentín-Feliciano, Alexandra K. Eckardt, Anya Goodman, Joseph W. Noynaert, Ashlee G. Johnson, Tyneshia C. P. Henry, Camille D. Ratliff, Ian O. Chase, Michel A. Conn, Jessica Koehler, Daniela Martiniuc, Allison J. Schepers, Megan B. Vylonis, Chrystel Dol, William Dirkes, Michelle S. Rivera-Llovet, Susana Rodríguez-Santiago, Heather L. Eisler, Mary L. Preuss, Daymon Peterson, Martin G. Burg, Aaditya Khatri, John R. Woytanowski, Holly Schiedermayer, Dara Cohn, Leah E Waldman, William M. Morris, Sharon C. Ehret, Marianna Defendini-Ávila, Jessica Fese, Suzette M. Arias-Mejias, Anna Kammrath, William D. Barshop, Edwin G. Ramírez-Aponte, Luis A. Jimenez, Carolina Marques dos Santos Vieira, Cody D. Kern, Francheska M. Delgado-Peraza, Tiffany Wan, Janice L. Krumm, Osagie Ighile, Eric D. Sassu, Jess M. Darusz, Laura Rodela, Daniel S. Nicolas, Shubha Govind, Mary Miller, Joseph E Marcus, Jason Pollack, Rostislav Castillo, Daniel Coomes, Matthew J. Borr, Diana Pérez-Afanador, Lucas A. Watson, Hannah C. Koaches, Amber Quintana, Faith H. Kung, Cameron B. Harris, Bridget M. Janssen, Cristina Zambrana-Echevarría, Jennifer K. Jones, Ian Dobbe, Benjamin M. Lewis, Lena N. Lupey, Julia A. Hilbrands, Cristina Montero Diez, Jorge L. Santiago-Ortiz, Dustin S. Woyski, Sandy D. Mach, Joseph Perez-Otero, Karim A. Sharif, Carlos Mendoza, John D. Fitzgibbons, Nelson H. Knudsen, Christy MacKinnon, Hayley M. Faber, Kwabea Agbley, Michelle Heslop, Olivia Cyrankowski, Priscilla Rodriguez, Melissa Jones, Jean M. Strelitz, Ryan A. Grove, Rachel A Greenstein, Michael Murillo, Elizabeth Greiner-Sosanko, Ciani Jean Sparks, Darryl McFarland, Franca G. Rossi, Heran Gebreyesus, Chris Kay, Danielle Ladzekpo, Chris Harward, Jordan S. Christie, Consuelo J. Alvarez, Elaine V. Morlock, Geoff Scott, Kelsey Hockenberger, Sepo Musokotwane, Adam Fearnow, Lauren J. Keny, Alaina J. Grantham, Evangelina Reza, Mike Colgan, Melanie K. Regan, Stephanie J. Potocny, Sasha L. Dorsett, Tara Skorupa, Valerie M. Gónzalez-Pérez, Vinayak S. Nikam, Anne C. Meier, Varun Sundaram, Helen B. Rankin, Andrew B. Nylander, Mariela Gines-Rosario, Laurell MacMillian, Jeannette M. Osterloh, Robert H. Allen, Melanie A. Smith, Sarah J. Spencer, Cheri M. Ackerman, Jeffrey L. Poet, Amanda J. Hay, Isaac O. Armistead, Laura K. Reed, Don W. Paetkau, Bib Yang, Enid M. Quintana-Torres, Kathryn L. Golden, Lauren A. DiLorenzo, Alen Ramic, Mark T. LeBlanc, Carl J. Minniti, Robert J. Bailey, Kristen M. Thomsen, Ashley L. Adams, Chad A. Koplinsky, Eliezer O. Perez-Colomba, Nicole A. Howey, Katie A. TerMeer, Stephanie Intriago, Christina N. Kufel, Mary Waters, Bo Liu, Thomas J. Bahr, Ashley R. Miller, Claire Pattison, Morgan R. Light, Amy T. Hark, Jennifer S. Doty, Catherine M. Mageeney, Adam J. Ronk, Nadezhda Fefelova, Andrew R. Armstrong, Maida Chen, Elizabeth Macias, Kim M. Chau, Paul Bilinski, Trevor G. Floyd, Cassidy T. Lee, Jenna C. Tenney, Bob Gardner, Patricia Ortiz-Ortiz, Elizabeth S. Jewell, Gabi Lucas, Brandon Lee, Jenifer N. Jarrell, Jimmy Hsiang-Chun Chang, Lorraine Malkowitz, Ulises Marrero-Llerena, Gabriel Stancu, Matthew R. Unzicker, Andrea P. Burgos-Bula, Michelle L. Miller, Elisandra Rivera, Kate Bagaeva, Jessica W. Polk, Jordan E. Carney, Maureen Corrielus, Jana Nietmann, Jeff Howenstein, Elizabeth Kiernan, Sabya A. Rauf, Brandon M. Katz, Elizabeth C. Nordman, Devon Shallman, Eric M. Clark, Lenin Lopez, Karen J. Kraftmann, Leslie Guadron, Julia Kuhn, Allison R. Schneiter, Satish C. Bhalla, Emily J. Howell, Blair Undem, Jeffrey S. Thompson, Arelys Flores-Vazquez, John Kiley, Cody M. Morrow, Joseline Serrano-González, John Mark Knepper, Christopher Beck, Calise Debow, Anna L. Smith, Angelica Garcia, Shelbi Christgen, Shadie Emiah, Tammy Mazur, Rachel E. VanDyken, Frank R. Soto delValle, Zachary Nichols, William R. Kennedy, Ameer Zidan, Douglas A. Herrick, Thomas Q. Xu, Elizabeth Shoop, Jessica A. Kampmeier, John M. Kerber, Caitlin Pozmanter, Emily L. Hong, Frederic J. Deuschle, Allyson B. Rivard, William Neutzling, Joseph V. Moran, Benjamin K. Johnson, Jacob Jipp, Shannon R. McCartha, Abby Vrable, Z. Goodwin, Suchita Rastogi, Alyssa M. Newman, Lionel Ortiz-Fuentes, Arjun A. Anilkumar, Bryan M. Hennessy, Hui-Min Chung, Katie L. Goeller, Carlos E. Santos-Ramos, Adam Dillman, Christine D. Wilson, Sarah J. Peacock, Andrew J. Kim, Carol I. Morales-Caraballo, Briana Brinkley, Justin Alldredge, Rebecca Krock, Kristen C. Davis, David Dunbar, Joshua L. Manghelli, Erica K. Earl, Katherine Gavinski, Sheryl T. Smith, Portia Mason, Lindsay J. Hoogenboom, Jessen T. Havill, Sonya G. Méndez-Castellanos, Darrin T. Schultz, Katherine J. Faber, Allison O’Rouke, Emily G. Miller, Yara Ashrawi, Curtiss E. Lane, Saryleine Ortiz-DeChoudens, Michael W. Sandusky, Andrew Montgomery, Rita Kabaso, Todd Aronhalt, Jonathan D. Foust, Jorge Ruiz, Eric Helmreich, Todd T. Eckdahl, Charlotte Lea, Kevin Coulson, Kristin M. French, Kate A. Woodard, Brandon J. Burkhart, Kylie McNeil, Curtis R. Edwards, Jimmy Ma, Darcie D. Elder, Tia DiTommaso, Nicholaus Monsma, Sarah A. Jelgerhuis, Stephanie J. Adams, Nichole Rigby, Heather L. Holderness, Charlotte Williams, Megan Donegan, Taylor S. Harding, Javier O. Martinez-Rodriguez, Sandeep Venkataram, Tiffany Wong, Anika Toorie, Jenny L. Rose, Ashley S. Brown, Sarah A. Popelka, Matthew Williams, Julie Bryant, Sarah C. R. Elgin, Sonali Kumar, Joshua Burkhardt, William J. Puetz, Erica L. Alvendia, Richard A. Tumminello, Kesley Parry, Joshua R. Smith, Ashley F. Custer, Carlos E. Ortiz, Yedda Li, April E. Bednarski, Simon Ng, Max Mandelbaum, Arlene J. Hoogewerf, Chelsea A. Walker, Ryan S. Lee, Jeannette Wong, Isabella Theresa Felzer-Kim, Harrison Friedman, Megan Bourland, Luis R. Colón-Cruz, Lucy Liu, Nicole C. Olson, Yi Ren, Adam P Lousararian, José M. Cruz-García, Charlie Manchee, Kyle Zoll, Kristina M. Stemler, Juliana Belén-Rodríguez, Ashley S. Timko, Jane Lopilato, England Raimey, Amy D. Melton, Joshua D. Forsyth, Christopher D. Savell, Himabindu Reddy, Alica B. Allen, Amanda Maffa, Daniel W. Cassidy, Luciann Bracero-Quiñones, Eric Lemmon, Justina R. Bartling, Bradley J. Ogden, Petros Svoronos, Mary Spratt, Lisa Sudmeier, Héctor A. Martell-Martínez, James F. Geary, Bridget J. Sessions, Christopher Campana, Kaitlyn A. Downey, Seth G. Dawson, Daniella Menillo, Casey Hanson, James M. Bellush, Justin A. Gonzales, Roy Song, Karvyn Torchon, Betsy Hoover, Michael Closser, Lacey Neufeld, Micah Shelton, Benjamin R. Does, Juan Carlos Martínez-Cruzado, Jordan S. Baumgardner, Nicole Chichearo, Mary T. Reilly, Colleen V. Kelley, Monica Yalamanchili, Dawn Lau, Abbie Morgan, Alyssa Cifelli, Milton R. Herrold, Ambreen Khan, James Messler, Kyle Westphal, James L. Kehoe, Juliana A. Wurzler, Garrett Salzman, Tracy Wang, Charlene Emerson, Lyndsey A. Reynolds, Alysha Moretti, Marita K. Abrams, Mara G. Cole, Michael B. Schultz, Samantha Cruz, Natalie Ngai, Nadia Safa, Vicente Velasquez, Ashley Townsend, Jonathan L. Crooke-Rosado, Amber M. Gygi, Ishwar S. Gill, Christopher McLaughlin, Dorianmarie Vargas-Franco, Alissa Beckett, Samantha Vue, Nadine L. Rossi, Justina Chinwong, Ryan Michael Rempe, Trip Freeburg, Amy J. Johnson, Omolara Glenn, Jade Lea Rekai, Hashini Gunasinghe, Vivienne Echendu, Marshall Strother, Morgan Baker, Christopher D. Smith, Paolo A. DaSilva, Noelle Delacruz, Tiara Tirasawasdichai, Yakov Shevin, Wilfried Guiblet, Shane M. Patao, Peterson R. Cullimore, Giancarlo F. Garbagnati, Adam E. Musick, Sarah C. Butzler, Jonathan D. Presley, Ana I. Correa-Muller, Christopher D. Shaffer, Chunguang Du, Ryan D. Mitchell, Jonathan P. Rennhack, Barbara L. Hopkins, Mary E. Shaw, Jessica E. Hill, Jeremy N. Wong, Anna Kim, Christopher B. Khoury, Julia Chapman, Amanda T. Mercer, Jessica A. Shuen, Joyce H. Lau, I.N. Falk, Sunil Rathore, Christopher J. Jones, Laura Simone Bisogno, Nighat P. Kokan, Paul Yenerall, Amber L. Price, Kelsey T. Bushhouse, Stephen L. McDaniel, Andrew P. Drake, Johnathan D. English, Sampson K. Boham, Robert A. Herbstsomer, Daniel S. Fosselman, Kevin Babilonia-Figueroa, Matthew Simon, Anne G. Rosenwald, Bryan J. Rupley, Heather Cohen, Victoria Scala, Avery B. Cromwell, Christopher E. Blunden, Yelena P. Davis, William B. Armstrong, Kristine Ostby, Joanna Haye, Lauren M. Wysocki, Lena Christiansen, Allison A. Throm, Sarah Flohr, Matthew Wawersik, Rebecca J. Cotteleer, Kristen R Ramirez, Dontae A. Jacobs, Sarah Woehlke, Gregory S. Messenger, Soham Aso, Nicole Clarke-Medley, Bryant R. Swanson, Lindsay K. Brouwer, S. Catherine Silver Key, Stephanie Zarrasola, Michael S. Salgado, Dong K. Rhee, Mai Abdelnabi, Eve VanEck, Jeremy Buhler, Sarah Kong, Turner Conrad, Jennifer Roecklein-Canfield, Marykathryn Tynon, Brian J. Maniaci, Alexa M. McDonough, Ivan G. Llavona-Cartagena, J. Devin Spencer, Todd D. Johnson, Azita Bashiri, Kimberley Ramsey, Mike Polen, Hien P Nguyen, Seantay D. Patterson, Lucia Wande, Nicholas U. Schwartz, Han Yuan, Albeliz Santiago-Colón, Joseph Medina, Samuel Thomas Crowley, Emma Shoemaker, Alex J. Feliciano-Cancela, Alexander J. Kujawski, Lillyann Asencio-Zayas, Gentry L. Pickett, Matt J. Randazzo, Erica Stagaard, Kristin M. LaForge, Gabriela A. Llaurador-Caraballo, Anastasia K. Yemelyanova, Alan Tseng, Erika E. Menyes, Julie Azarewicz, Christa Burke, Samuel I. Smith, Nazanin Ghavam, Carolina Gomez, Cameron Fick, Anthony Pinto, Lindsay Rios, Gary A Kuleck, Ashley Rich, Kayla A. Florian, Martin N. Cheramie, Yuki Kwan Wa Shum, Atlee Baker, LaJerald Augustine, Alyson Greenwell, Rasleen K. Saluja, Jason S. Macias, Wesley W. Winn, Samantha M. Schmuecker, Michelle E. M. Eisen, Pedro Benitez, Jeanette Hauke, Nora C. Goscinski, Justin R. DiAngelo, Carter T. Docking, David D. Xiong, Brittany D. Pasierb, Matt Van Camp, Yin Zheng, Nikie L. McCabe, Emily Reed, Katie Homa, Kimberly S. Kolibas, Elizabeth A. Karaska, Grace A. Dougherty, John P. Fanning, Michael Fasano, Joseph E. Sable, Robert W. Schulz, San Francisco Nguyen, Michael L. Rojas-Vargas, Kierstin L. Naylor, Emily Peoples, Jessica Neely, Lejla Cesko, Brionna D. Davis-Reyes, Roxanne Banker, Amanda K. Tilot, Jordan P. Brand, William H. Newhart, Lauriaun Johnson, Michelle M. Giddens, Nicole B. Clark, Anant Agarwalla, Thomas F. Minton, Dana W. Brooks, Amanda D. Garrett, Bethany M. Klett, Kristin M. Starkey, Antoinette E. Fafara-Thompson, Michael R. Rubin, Jonathon M. Benson, Erica Enoch, Amanda M. Damsteegt, Zackary W. Scott, Elisabeth A. Kelly, Jason M. Barnett, Wilson Leung, Luke J. Rodriguez-Giron, Krishna C. Mudumbi, Francis J. May, Nadyan M. Vargas-Barreto, Geeta Statton, José L. Torres-Castillo, Sarah Hirsch, Rachel M. Reem, Linghui Li, Deirdre Robinett, Jason Caronna, Abneris E. Rodríguez-Laboy, Samantha Lawrence, Katherine R. Reynolds, Corinne Weeks, Allison M. Sterling, Chun Leung Ng, Roman E. Ramirez, Daron C. Barnard, Leming Zhou, Eric P. Spana, John A. Toth, Alvin Lu, Krizia C. Menéndez-Serrano, Jonathan M. Heckman, Ben Chlebina, Matthew C. Fadus, Helmet T. Karim, Shailly Gaur, Timothy R. Jelsema, Nicholas Keysock, Thomas J. Carr, Zach Fusco, Evan M. Verbofsky, Monal Naik, Amanda H. Flores, Kristin A. Knouse, Olga R. Kopp, Elizabeth Feenstra, Edward P. Sweeney, Christen Johnson, Justin Crawford, Damian Urick, Victor W. Mullen, Carrie A. Dunham, Gabriella A. DeMichele, Mengyang Sun, William Harrington, Jessica M. Bodenberg, Xavier A. Collado-Méndez, T. Aaron Wiles, Michelle K. Powers, Phillip J. Minnick, Lourdes N. Irizarry-González, Valeria Silva, Steven Ovu, Nik Kolba, Peter Lindbeck, Jerome M. Molleston, Ifeanyi Obiorah, David Carranza, Lauren R. Beck, Alina M. Tamayo-Figueroa, Elaine R. Mardis, Rachel N. Lippert, Ingrid T. Rivera-Pagán, Mahdi Soos, Trung T. Nguyen, Megan Martinez, Van Kim, Benjamin L. Danner, Randall J. DeJong, Melissa M. Trieu, Andrea M. Senquiz-Gonzalez, Mary Grace Schueler, Emily E. Magnuson, Lesley E. Jackson, Hendrick Pagán-Torres, Fareed Sanusi, Dana Koenig, Vidya Chandrasekaran, Chinmoy I. Bhatiya, Dongyeon Kim, Paul J. Overvoorde, Reece Watson, Jennifer Schottler, Devry Lin, Jim Youngblom, Taylor Schauder, Nigel Madden, Isabel Valdez, Thomas John Reynolds, Kelly M. Deranek, Anne A. Welker, Jackie X. White, Nicole C. Riddle, Jacob Pfeil, Aldo Heredia-Negrón, Christine Langner, Tao Jian He, Jonathan P. Mecoli, Lissett Mayorga, Scott Chiang, Rishi Singhal, Julia C. Peairs, Michael Quach, Anne M. Eime, GiNell Elliott, Meleah J. Gross, Melissa Drewry, Julia A. Emerson, Anthony K. Lambright, Isaac Appiah, Gregory M. Robertson, Nathaniel Regenold, Philip Pham, George Odisho, Alexi Archambault, Matthew Dothager, Shana M. Baldassari, Paul J. Lee, Callie R. Merry, Jesse R. Farek, Archana Tare, Srebrenka Robic, William Vernon, Tam Vuong, Bethany Grace Bonifield, Katrina Thistle, Rose M. Dowd, Noor Tazudeen, Jennifer Weaver, Manpreet Kaur, Nicole M. Caesar, Yi Zhang, Michael C. Cristostomo, Albert Tzeng, Kayla Vondy, Emily Perling, Ramiro A. Chavez, Lanor S. Horton, Matt Kroll, Levent H. Beken, Justin R. Starcher, Sam Asinof, Nathalia M. Cruz, Eunice George, Adam T. Morrow, Heather Milnthorp, Cheryl Mazzeo, Kristen R. Hatfield, Anna L. Boudoures, Ashley A. Tewilliager, Edna P. Tascón-Peñaranda, Vilma F. Huerta, Sarah Tuberty, Mallory A. Williams, Rachel E. Weber, Sarah Spencer, Emily C. Leatherman, Yuying Gosser, Steve DeFazio, Patrick Ng, Jeri Sparks, Pavan Bhat, Mindy E. Bower, Jordan E. Matthews, Cyrus E. Kuschner, Anne Bertolet, Matt Kusner, Thomas C. Giarla, Jessica Penn, Gerard P. McNeil, Mariam Meghdari, Michael J. Wolyniak, Matthew Juergens, Karla I. Velázquez-Soto, Maria Kaisler, Jeanine Schibler, Alexis Nagengast, Susan Parrish, Frances Marín-Maldonado, Shiv Mohini, Jessica King, Danny Mammo, Katherine S. Harker, Allyson P. Hawkins, Kelly Drumm, Jennifer A. Lammers, Allyson P Mallya, Ashley Bryant, Katie Weihbrecht, Pete Wendland, Gabriela V. Bernal-Vega, Nestor A. Gutierrez, Armando G. Bermudez-Capo, Luke R. Salbert, Kirk Haltaufderhyde, Michelle L. Kappes, Mary A. Smith, York Chen, Miguel Vélez-Vázquez, Brittany E. Plescher, Francis D. Beauchamp-Pérez, Alyssa Ward, Andrea N. Clary, Don Foret, Mitchell J McDonald, Mariela Colon-Vazquez, Amanda L. Blaker, Hao Yang, James Z. Liu, Austin B. Limle, Henry Huang, Luis Vilanova-Velez, Edgar Garibay, Philip J. Freda, Laura L. Mays Hoopes, Maureen S. Hammond, Marian M. Kaehler, Rebecca Shuford, Ray Sunjed, Cynthia K. Hanson, Marielle VanderVennen, Idaliz M. Martínez-Traverso, Jack Y. Yu, Spencer L. Franchi, Michael Snavely, John E. Anderson, Lainey S. Rubin, Kelly K. Jones, Stephanie F. Mel, Stacey Lytle, Danny L. Tran, Chelsea R. Barberi, Max Mian Liu, Eric A. Nollet, Sarah E. Muller, Diana Norton, John M. Braverman, Thu A. Phan, Nelson Membreno, Colin Khoshabian, John Gooch, Cassandra Kubricky, Priscila M. Rodríguez-García, Anna Wylie, Diana L. E. Johnson, Anna K. Unruh, Deborah Hammett, Jon Sarezky, Marie Brown, Carolina Riascos-Cuero, Emily J. Diekema, Emmy E. Ogawa, Miranda Chavez, Zuzana Kocsisova, Dennis Revie, Anniken M. Lydon, Peter A. Cognetti, Ashley A. Collins, Tariq Abusheikh, Erin K. Luippold, Kevin Myirski, Brian O. Rodríguez-Echevarría, Haley J. Plasman, Lara Baatenburg, Jesse Hendriksma, Christopher R. Knob, Max Semon, Cassandra Farrar, Xiao Zhu, Ali Dobbe, Marie-Isabelle B. Seydoux, Griffin Sadovsky, Shreya Prasad, Victoria Newcomb, Chad Gier, Dmitri Serjanov, Jules Wellinghoff, Maxwell T. Smith-Gee, and Alexandra H. Scoma
Subjects: Transposable element, Codon Adaptation Index, Euchromatin, Heterochromatin, transposons, evolution of heterochromatin, Investigations, Genome, Evolution, Molecular, 03 medical and health sciences, gene size, 0302 clinical medicine, melting characteristics, Species Specificity, codon bias, Genetics, Animals, Drosophila Proteins, Selection, Genetic, Codon, Molecular Biology, Genetics (clinical), 030304 developmental biology, Polytene Chromosomes, Repetitive Sequences, Nucleic Acid, Gene Rearrangement, 0303 health sciences, biology, Computational Biology, Molecular Sequence Annotation, Gene rearrangement, Exons, Genomics, biology.organism_classification, Introns, Drosophila melanogaster, Codon usage bias, DNA Transposable Elements, Drosophila, 030217 neurology & neurosurgery
Abstract: The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu.
Published: 2015

113. A NORTHERN SKY SURVEY FOR POINT-LIKE SOURCES OF EeV NEUTRAL PARTICLES WITH THE TELESCOPE ARRAY EXPERIMENT

Author: R. Ishimori, R. W. Springer, John Belz, Gordon Thomson, Federico R. Urban, K. Hibino, W. R. Cho, Nobuyuki Sakurai, Tomohiro Matsuda, Pierre Sokolsky, Sergey Troitsky, Masayuki Tanaka, ByongGu Cheon, Yuichiro Tameda, John N. Matthews, Younghoon Kwon, M. J. Chae, K. Martens, Y. Yoneda, S. I. Lim, Thomas Stroman, M. Ohnishi, S. Kawana, Kenichi Kadota, M. Abe, Il Hung Park, Douglas Bergman, H. Yoshii, S. Kitamura, Tomoyuki Nakamura, Fumio Kakimoto, H. Kawai, S. Udo, C. C. H. Jui, Mayuko Minamino, S. Nagataki, S. Kawakami, A. L. Sampson, K. Oki, Yasunori Kitamura, A. Oshima, Takaaki Ishii, S. B. Thomas, Elliott Barcikowski, Hirotaka Ito, Maxim Pshirkov, Masaomi Ono, K. Nagasawa, Dmitri Ivanov, Tatsunobu Shibata, Toshio Matsuyama, H. Shimodaira, HangBae Kim, Kenta Yashiro, Kenichi Tanaka, T. Suzawa, H. Tanaka, Isaac Myers, T. Goto, M. Takamura, Hiroyuki Sagawa, Shunsuke Ozawa, Naoya Inoue, K. Tsutsumi, J. Ogura, Priti Shah, B. T. Stokes, Igor Tkachev, Jon Paul Lundquist, Grigory Rubtsov, Akimichi Taketa, Oleg Kalashev, Takayuki Tomida, Masahiro Takeda, Naoaki Hayashida, L. M. Scott, H. Yamaoka, Ken Honda, A. Nozato, Y. Hayashi, V.A. Kuzmin, Zach Zundel, K. Machida, K. Yamazaki, Tareq Abu-Zayyad, R. Yamane, K. Mukai, H. Ohoka, J. Yang, J. Lan, R. Zollinger, B. K. Shin, Yoshiki Tsunesada, Daisuke Ikeda, S. R. Stratton, S. Yoshida, Katsuaki Kasahara, Tiffany Wong, R. Takeishi, Masaki Fukushima, Mark Allen, Masato Takita, Michiyuki Chikawa, Yukio Uchihori, Takahiro Fujii, Peter Tinyakov, Samuel Blake, Shoichi Ogio, J. H. Kim, Kazumasa Kawata, R. Azuma, J. D. Smith, D. Rodriguez, H. Tokuno, Eiji Kido, Toshiyuki Nonaka, Ruth A. Anderson, William Hanlon, Rasha Abbasi, Robert Cady, T. Okuda, G. Vasiloff, Jyunsei Chiba, Dongsu Ryu, and Fumiya Shibata
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Flux, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Scintillator, Coincidence, law.invention, Telescope, Space and Planetary Science, Neutron flux, Sky, law, Astrophysics - High Energy Astrophysical Phenomena, Order of magnitude, Astrophysics::Galaxy Astrophysics, Fermi Gamma-ray Space Telescope, media_common
Abstract: We report on the search for steady point-like sources of neutral particles around 10$^{18}$ eV between 2008 May and 2013 May with the scintillator surface detector of the Telescope Array experiment. We found overall no significant point-like excess above 0.5 EeV in the northern sky. Subsequently, we also searched for coincidence with the Fermi bright Galactic sources. No significant coincidence was found within the statistical uncertainty. Hence, we set an upper limit on the neutron flux that corresponds to an averaged flux of 0.07 km$^{-2}$ yr$^{-1}$ for $E>1$ EeV in the northern sky at the 95% confidence level. This is the most stringent flux upper limit in a northern sky survey assuming point-like sources. The upper limit at the 95% confidence level on the neutron flux from Cygnus X-3 is also set to 0.2 km$^{-2}$ yr$^{-1}$ for $E>0.5$ EeV. This is an order of magnitude lower than previous flux measurements., 27 pages, 10 figures, 3 tables, accepted for publication in the Astrophysical Journal
Published: 2015

114. Energy spectrum of ultra-high energy cosmic rays observed with the Telescope Array using a hybrid technique

Author: S. Y. Roh, S. Yoshida, T. Kanbe, John Belz, Y. Murano, Thomas Stroman, Akitoshi Oshima, R. Zollinger, S. Kitamura, K. Nagasawa, Takayuki Tomida, Michiyuki Chikawa, Isaac Myers, H. Tokuno, K. Kitamoto, R. W. Springer, Igor Tkachev, R. Cady, Elliott Barcikowski, R. Aida, Eiji Kido, Toshiyuki Nonaka, Dmitri Ivanov, H. Fujii, H. Tanaka, Byung Gu Cheon, Yukio Uchihori, J. H. Kim, Pierre Sokolsky, Naoya Inoue, T. Fujii, Mayuko Minamino, Tatsunobu Shibata, Tomohiro Matsuda, Ross Anderson, Peter Tinyakov, Yasunori Kitamura, Samuel Blake, Shoichi Ogio, Toshio Matsuyama, K. Kobayashi, X. Zhou, Y. Yoneda, K. Tsutsumi, S. I. Lim, Zach Zundel, Sergey Troitsky, S. Machida, K. Martens, Hirotaka Ito, Younghoon Kwon, Shunsuke Ozawa, Mark Allen, S. Udo, C. C. H. Jui, Hiroyuki Sagawa, S. Kawana, H. Kawai, E. J. Cho, H. Shimodaira, M. Tanaka, S. Iwamoto, Y. Kondo, K. Oki, Tomoyuki Nakamura, S. Kawakami, Masaomi Ono, S. B. Thomas, S. Nagataki, Naoaki Hayashida, K. Miyata, R. Azuma, T. Matsuura, Fumiya Shibata, Y. Tsuyuguchi, Jon Paul Lundquist, Yoji Kobayashi, Kiyoshi Kuramoto, T. Shirahama, Takaaki Ishii, Gordon Thomson, B. T. Stokes, Yoshiki Tsunesada, K. Hibino, R. Ishimori, Daisuke Ikeda, S. R. Stratton, H. Yamaoka, Grigory Rubtsov, K. Hayashi, Hang Bae Kim, Katsuaki Kasahara, Akimichi Taketa, Tiffany Wong, T. Fukuda, Kenichi Tanaka, Masaki Fukushima, A. L. Sampson, S. Suzuki, Hyun-Il Kim, Douglas Bergman, Federico R. Urban, Masato Takita, Nobuyuki Sakurai, D. Oku, K. Hiyama, H. Yoshii, William Hanlon, Yukio Takahashi, G. Vasiloff, K. Ikuta, J. I. Shin, T. Okuda, Jyunsei Chiba, Maxim Pshirkov, Dongsu Ryu, Fumio Kakimoto, Y. Yamakawa, S. W. Nam, H. Ukai, Priti Shah, T. Iguchi, J. D. Smith, D. Rodriguez, Masahiro Takeda, Ken Honda, Yuichiro Tameda, John N. Matthews, M. Ohnishi, L. M. Scott, Y. Hayashi, V.A. Kuzmin, B. K. Shin, K. Yamazaki, Tareq Abu-Zayyad, R. Yamane, H. Ohoka, J. Yang, J. Lan, W. R. Cho, Kenichi Kadota, Il Hung Park, Y. Wada, and Oleg Kalashev
Subjects: Physics, Astrophysics::High Energy Astrophysical Phenomena, Detector, Astronomy and Astrophysics, Cosmic ray, Astrophysics, 7. Clean energy, Spectral line, Computational physics, law.invention, Telescope, Air shower, law, Energy spectrum, Ultra-high-energy cosmic ray
Abstract: We measure the spectrum of cosmic rays with energies greater than 10 18.2 eV with the fluorescence detectors (FDs) and the surface detectors (SDs) of the Telescope Array Experiment using the data taken in our first 2.3-year observation from May 27, 2008 to September 7, 2010. A hybrid air shower reconstruction technique is employed to improve accuracies in determination of arrival directions and primary energies of cosmic rays using both FD and SD data. The energy spectrum presented here is in agreement with our previously published spectra and the HiRes results.
Published: 2015

115. Gain monitoring of telescope array photomultiplier cameras for the first 4 years of operation

Author: Y. Uchihori, X. Zhou, B. G. Cheon, Takaaki Ishii, T. Kanbe, Robert M. Anderson, J. Martineau, D. C. Rodriguez, Grigory Rubtsov, Isaac Myers, Y. Kobayashi, A. L. Sampson, S. Kawakami, H. Yoshii, K. Tsutsumi, H. Tokuno, Yuichiro Tameda, John N. Matthews, L. M. Scott, Y. Hayashi, Hiroyuki Sagawa, J. D. Smith, Takayuki Tomida, K. Kitamoto, R. Azuma, T. Matsuura, Mayuko Minamino, K. Honda, Yasunori Kitamura, S. Yoshida, Vladim Kuzmin, R. Zollinger, R. Aida, Masaaki Tanaka, Hideaki Shimodaira, K. Hibino, Yoshiki Tsunesada, K. Yamazaki, Daisuke Ikeda, Fumiya Shibata, Tareq Abu-Zayyad, R. Yamane, R. Ishimori, S. R. Stratton, Ben Stokes, Tiffany Wong, T.-A. Shibata, Gordon Thomson, Tom Stroman, Robert Cady, T. Fukuda, Takeshi Okuda, Igor Tkachev, Masaki Fukushima, T. Shirahama, S. Y. Roh, Hyun-Il Kim, S. Kitamura, M. Allen, T. Matsuyama, Samuel Blake, E. J. Cho, Y. Kondo, Shoichi Ogio, K. Oki, Michiyuki Chikawa, Inkyu Park, K. Nagasawa, Shingo Kawana, T. Fujii, Eiji Kido, William Hanlon, Sergey Troitsky, S. Machida, R. W. Springer, J. I. Shin, Naoaki Hayashida, Y. Tsuyuguchi, Maxim Pshirkov, Kiyoshi Tanaka, Elliott Barcikowski, Dmitri Ivanov, H. Fujii, K. Hayashi, H. Kawai, K. Kasahara, Fumio Kakimoto, Tomohiro Matsuda, K. Ikuta, Nobuyuki Sakurai, Akitoshi Oshima, K. Kobayashi, Shunsuke Ozawa, John Belz, Y. Murano, Pierre Sokolsky, M. Takeda, Shigehiro Nagataki, K. Kuramoto, Yasuhiro H. Takahashi, Masato Takita, Zach Zundel, O. Kalashev, T. Iguchi, M. Wood, P. Tinyakov, Y. Yamakawa, K. Martens, Hideki Tanaka, Y. J. Kwon, Toshiyuki Nonaka, Hiroshi Yamaoka, Hideyuki Ohoka, J. Yang, H. Ukai, Priti Shah, K. Miyata, Hongsu Kim, Bokkyun Shin, Akimichi Taketa, S. Suzuki, Douglas Bergman, D. Oku, K. Hiyama, Y. Yoneda, N. Inoue, S. I. Lim, M. Ohnishi, S. Udo, C. C. H. Jui, S. B. Thomas, S. W. Nam, W. R. Cho, Toru Nakamura, Kenichi Kadota, Y. Wada, T. J. Sonley, S. Iwamoto, G. Vasiloff, Jyunsei Chiba, Dongsu Ryu, and J. H. Kim
Subjects: Physics, Telescope, Nuclear and High Energy Physics, Photomultiplier, Optics, business.industry, law, Night sky, Optoelectronics, Scintillator, business, Instrumentation, law.invention
Abstract: The stability of the gain of the photomultiplier (PMT) camera for the Fluorescence Detector (FD) of the Telescope Array experiment was monitored using an 241 Am loaded scintillator pulsers (YAP) and a diffused xenon flasher (TXF) for a selected set of 35 PMT-readout channels. From the monitoring of YAP pulses over four years of FD operation, we found slow monotonic drifts of PMT gains at a rate of −1.7~+1.7%/year. An average of the PMT gains over the 35 channels stayed nearly constant with a rate of change measured at −0.01±0.31(stat)±0.21(sys)%/year. No systematic decrease of the PMT gain caused by the night sky background was observed. Monitoring by the TXF also tracked the PMT gain drift of the YAP at 0.88±0.14(stat)%/year.
Published: 2014

116. Poster 489: Risk Factor Analysis and Practical Screening Protocol for Deep Vein Thrombosis in Patients with Traumatic Spinal Cord Injuries on Admission to Inpatient Rehab

Author: Brandon L. Hicks, Marc A. Raj, Jonathan H. Greenwald, Eric F. Sterne, Matthew B. Bloom, Tiffany Wong, Gary Glynn, Sarah E. Clevenger, John L. Faciane, Alexis J. Carimi, and Kelly L. Paulk
Subjects: medicine.medical_specialty, business.industry, Deep vein, Rehabilitation, Physical Therapy, Sports Therapy and Rehabilitation, Spinal cord, medicine.disease, Thrombosis, Surgery, medicine.anatomical_structure, Neurology, medicine, In patient, Neurology (clinical), Risk factor, business
Published: 2017

117. Combined and alternating paracetamol and ibuprofen therapy for febrile children

Author: Antonia S Stang, Anna M Thomsen, David W. Johnson, Tiffany Wong, Heather Ganshorn, Lisa Hartling, and Ian Maconochie
Subjects: business.industry, Anesthesia, Pediatrics, Perinatology and Child Health, Medicine, General Medicine, business, Ibuprofen, medicine.drug
Published: 2014

118. First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy

Author: Edmond S. Chan, Elissa M. Abrams, Kyla J. Hildebrand, Lianne Soller, Scott B. Cameron, Timothy K. Vander Leek, Sara Leo, Gregory Rex, Joanne Yeung, Per G. Lidman, Victoria E. Cook, Nicole J. Lee, Mary McHenry, Sandeep Kapur, Raymond H. Mak, Stuart C. Carr, Thomas V. Gerstner, and Tiffany Wong
Subjects: Male, Canada, medicine.medical_specialty, Allergy, Arachis, Peanut allergy, Administration, Oral, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, medicine, Humans, Immunology and Allergy, Peanut Hypersensitivity, 030212 general & internal medicine, Eosinophilic esophagitis, Adverse effect, Skin Tests, Oral food challenge, business.industry, Maintenance dose, Infant, Allergens, Immunoglobulin E, medicine.disease, Clinical trial, 030228 respiratory system, Desensitization, Immunologic, Child, Preschool, Female, business
Abstract: Background In 2017, a clinical trial of 37 subjects demonstrated that preschool peanut oral immunotherapy (P-OIT) was safe, with predominantly mild symptoms reported and only 1 moderate reaction requiring epinephrine. Objectives We sought to examine whether these findings would be applicable in a real-world setting. Methods As part of a Canada-wide quality improvement project, community and academic allergists administered P-OIT to preschool-age children who had (1) skin prick test wheal diameter greater than or equal to 3 mm or specific IgE level greater than or equal to 0.35 kU/L and history of reaction and/or positive baseline oral food challenge, or (2) no ingestion history and specific IgE level greater than or equal to 5 kU/L. Over 16 to 22 weeks, patients had biweekly clinic visits for updosing, and consumed the dose daily at home between visits. Target maintenance dose was 300 mg peanut protein. Symptoms were classified using a modified World Allergy Organization Subcutaneous Immunotherapy Reaction Grading System (1 mildest, 5 fatal). Results Of 270 patients who started P-OIT in the period 2017 to 2018, 243 reached maintenance, and 27 dropped out (10.0%); 67.8% of patients experienced reactions during buildup: 36.3% grade 1, 31.1% grade 2, and 0.40% grade 4. Eleven patients (4.10%) received epinephrine (10 patients received 1 dose, 1 patient received epinephrine on 2 separate days), representing 2.23% of reactions (12 of 538) and 0.029% of doses (12 of 41,020). Conclusions We are the first group to describe preschool P-OIT in a real-world multicenter setting. The treatment appears to be safe for the vast majority of patients because symptoms were generally mild and very few reactions received epinephrine; however, life-threatening reactions in a minority of patients (0.4%) can still occur.
Published: 2019

119. First ever real-world safety analysis of preschool peanut oral immunotherapy

Author: Mary McHenry, Sandeep Kapur, Scott Cameron, Joanne Yeung, Gregory Rex, Victoria E. Cook, Nicole J. Lee, Sara Leo, Stuart C. Carr, Tiffany Wong, Elissa M. Abrams, Edmond S. Chan, Kyla J. Hildebrand, Per G. Lidman, Timothy K. Vander Leek, and Lianne Soller
Subjects: medicine.medical_specialty, Oral immunotherapy, business.industry, Immunology, medicine, Immunology and Allergy, Intensive care medicine, business
Published: 2019

120. Outcomes of oral food challenges and observed first ingestions among infants under 12 months of age

Author: Catherine M. Biggs, Lianne Soller, Edmond S. Chan, Tiffany Wong, Kyla J. Hildebrand, Victoria E. Cook, and Alanna Chomyn
Subjects: Immunology, Immunology and Allergy
Published: 2019

121. The energy spectrum of ultra-high-energy cosmic rays measured by the Telescope Array FADC fluorescence detectors in monocular mode

Author: T. Kanbe, Y. Kobayashi, Fumiya Shibata, S. Kitamura, Robert M. Anderson, R. Ishimori, Hidemi Ito, Sergey Troitsky, Grigory Rubtsov, Isaac Myers, T. Matsuyama, Y. Yamakawa, S. Yoshida, H. Ukai, Priti Shah, Yuichiro Tameda, S. Suzuki, Taka Tomida, T. Shirahama, John N. Matthews, Douglas Bergman, Pierre Sokolsky, R. Zollinger, D. Oku, K. Hiyama, Y. J. Kwon, Hiroyuki Sagawa, K. Ikuta, Hideyuki Ohoka, Hideaki Shimodaira, M. Takeda, J. H. Kim, M. Allen, T. J. Sonley, Shigehiro Nagataki, K. Oki, Charlie Jui, J. Ogura, Y. Kondo, Akimichi Taketa, Naoaki Hayashida, Y. Tsuyuguchi, K. Kasahara, K. Kitamoto, J. P. Lundquist, Takaaki Ishii, Toshiyuki Nonaka, Mayuko Minamino, K. Honda, S. Y. Roh, B. G. Cheon, Takeshi Okuda, Igor Tkachev, T. Iguchi, A. L. Sampson, D. C. Rodriguez, S. Iwamoto, John Belz, Inkyu Park, K. Miyata, Masaomi Ono, J. I. Shin, Yasunori Kitamura, K. Yamazaki, Bokkyun Shin, S. Kawakami, Y. Murano, Tareq Abu-Zayyad, Vladim Kuzmin, R. Yamane, T. Fujii, K. Tsutsumi, Hiroshi Yamaoka, R. Aida, Masaaki Tanaka, G. Vasiloff, R. Azuma, T. Matsuura, Elliott Barcikowski, T.-A. Shibata, L. M. Scott, K. Hibino, Jyunsei Chiba, Dongsu Ryu, Gordon Thomson, Tom Stroman, Robert Cady, Y. Hayashi, Hongsu Kim, Dmitri Ivanov, H. Fujii, Y. Uchihori, O. Kalashev, W. R. Cho, H. Kawai, Hyun-Il Kim, Kiyoshi Tanaka, H. Yoshii, Eiji Kido, Yoshiki Tsunesada, K. Kuramoto, Y. Yoneda, N. Inoue, S. I. Lim, Daisuke Ikeda, Toru Nakamura, Kenichi Kadota, S. R. Stratton, M. Ohnishi, S. Machida, S. Udo, J. Yang, Y. Wada, Tiffany Wong, J. Lan, S. B. Thomas, Nobuyuki Sakurai, S. W. Nam, T. Fukuda, Masaki Fukushima, Peter Tinyakov, Samuel Blake, Shoichi Ogio, E. J. Cho, Michiyuki Chikawa, Yasuhiro H. Takahashi, Zach Zundel, Masato Takita, K. Martens, Hideki Tanaka, H. Tokuno, J. D. Smith, R. W. Springer, Tomohiro Matsuda, K. Kobayashi, Shingo Kawana, William Hanlon, Maxim Pshirkov, K. Hayashi, Fumio Kakimoto, Akitoshi Oshima, Shunsuke Ozawa, and Ben Stokes
Subjects: Astroparticle physics, Physics, business.industry, Aperture, Monte Carlo method, Detector, Astronomy and Astrophysics, Cosmic ray, law.invention, Telescope, Optics, law, Ultra-high-energy cosmic ray, business, Event reconstruction
Abstract: We present a measurement of the energy spectrum of ultra-high-energy cosmic rays performed by the Telescope Array experiment using monocular observations from its two new FADC-based fluorescence detectors. After a short description of the experiment, we describe the data analysis and event reconstruction procedures. Since the aperture of the experiment must be calculated by Monte Carlo simulation, we describe this calculation and the comparisons of simulated and real data used to verify the validity of the aperture calculation. Finally, we present the energy spectrum calculated from the merged monocular data sets of the two FADC-based detectors, and also the combination of this merged spectrum with an independent, previously published monocular spectrum measurement performed by Telescope Array’s third fluorescence detector [T. Abu-Zayyad et al., The energy spectrum of Telescope Array’s middle drum detector and the direct comparison to the high resolution fly’s eye experiment, Astroparticle Physics 39 (2012) 109-119, http://dx.doi.org/10.1016/j.astropartphys.2012.05.012 , Available from: ]. This combined spectrum corroborates the recently published Telescope Array surface detector spectrum [T. Abu-Zayyad, et al., The cosmic-ray energy spectrum observed with the surface detector of the Telescope Array experiment, ApJ 768 (2013) L1, http://dx.doi.org/10.1088/2041-8205/768/1/L1 , Available from: ] with independent systematic uncertainties.
Published: 2013

122. A review of Caesarean section techniques and postoperative thromboprophylaxis at a tertiary hospital

Author: Eng Loy Tan, Devendra Kanagalingam, Tuck Chin Tiffany Wong, and Chang Qi Hester Lau
Subjects: Adult, medicine.medical_specialty, medicine.medical_treatment, Surgical drains, Postoperative Hemorrhage, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, Fetal head, Caesarean section, 030212 general & internal medicine, General hospital, Retrospective Studies, Singapore, 030219 obstetrics & reproductive medicine, Parietal peritoneum, business.industry, Cesarean Section, General surgery, Suture Techniques, General Medicine, Delivery suite, Female, Original Article, business
Abstract: INTRODUCTION Although Caesarean sections (CSs) are among the most commonly undertaken procedures in the world, there are wide variations in the surgical techniques used. This study aimed to: (a) review the surgical techniques used for CS by obstetricians working in a tertiary hospital in Singapore; (b) compare the techniques with those recommended in evidence-based guidelines; and (c) examine the relationship between the technique used and the level of seniority of the surgeons. METHODS Data on 490 CSs performed in Singapore General Hospital (SGH) between 1 August 2013 and 30 June 2014 was collected from the Delivery Suite database and reviewed. The surgical techniques studied were closure of the pelvic and parietal peritoneum, closure of the uterine layer, use of surgical drains and use of postoperative thromboprophylaxis. RESULTS A total of 486 CSs were analysed after four cases were excluded due to missing data. Most fetal head deliveries were manual. The majority of surgeons did not close the peritoneum; most of those who did were senior surgeons. Double-layer uterine closures were done for all cases and drain usage was rare. 2.0% of the patients received grossly inadequate thromboprophylaxis. CONCLUSION The surgical techniques currently practised in SGH are closely aligned with those of the evidence-based guidelines. Peritoneal closure appears to be associated with the surgeon's early training, with a greater number of senior surgeons being less willing to abandon this step. Greater vigilance in implementing appropriate thromboprophylaxis is recommended.
Published: 2016

123. Impact of supervised epinephrine autoinjector administration during food challenges on parent confidence

Author: Tiffany Wong, Edmond S. Chan, Christopher Mill, Angela Alexander, Kyla J. Hildebrand, Timothy Teoh, Boris Kuzeljevic, Ingrid Baerg, and John M. Dean
Subjects: Pulmonary and Respiratory Medicine, Health Knowledge, Attitudes, Practice, Adolescent, Epinephrine, Immunology, 03 medical and health sciences, 0302 clinical medicine, medicine, Immunology and Allergy, Humans, Epinephrine autoinjector, 030212 general & internal medicine, Child, Anaphylaxis, business.industry, medicine.disease, Food hypersensitivity, 030228 respiratory system, Anesthesia, Child, Preschool, business, Administration (government), Food Hypersensitivity, medicine.drug
Published: 2016

124. Review Essay— Helen Nissenbaum'sPrivacy in Context: Technology, Policy, and the Integrity of Social Life(2010)

Author: Tiffany Wong
Subjects: 050502 law, National security, business.industry, 05 social sciences, Internet privacy, ComputingMilieux_LEGALASPECTSOFCOMPUTING, Context (language use), 0506 political science, Supreme court, Scholarship, 050602 political science & public administration, Social media, Constitutional right, Sociology, Social science, business, Law, Personally identifiable information, Privilege (social inequality), 0505 law
Abstract: Social media is a dominating force in modern social life as internet technology has taken hold of our cyber-driven society. Many scholars, as will be explored below, have articulated fears and enthusiasm about what can be interpreted as a reconfiguration of privacy in a culture mediated by technology. Scholarship ranges from those opposing new conception of privacy in favour of protecting rights in traditional private/public distinctions with privacy as a privilege worthy of proprietary protection to those reveling in opening floodgates for information to re-invent or even destroy any semblance of traditional distinctions of privacy. These poles become even more accentuated in light of fast-proliferating technology illustrated by popular social networking websites such as Facebook, Twitter, Foursquareetc.In the North-American debate, the privacy concerns connected with these developments are compounded further by the U. S. Supreme Court's recent decision,Nelson v. NASA, which involves the constitutional right of government to ask for employee's personal information in the context of national security and surveillance.
Published: 2011

125. Ionic liquid batteries: Chemistry to replace alkaline/acid energy storage devices

Author: Karen McGrady, Tiffany Wong, Thomas E. Sutto, and Teresa Duncan
Subjects: General Chemical Engineering, Inorganic chemistry, Electrolyte, Electrochemistry, Energy storage, Cathode, Anode, law.invention, chemistry.chemical_compound, chemistry, law, Ionic liquid, Ionic conductivity, Separator (electricity)
Abstract: Rather than depend on highly acidic or basic electrolytes, ionic liquids are used to create new types of solid state cells which mimic standard alkaline cells, but without the need for caustic electrolytes. Presented here is a non-aqueous approach to primary and secondary power sources, where the pure ionic liquid not only acts as the electrolyte/separator in both liquid and solid state batteries, but as a reactive species in the cell's electrochemical makeup. In this work, batteries are designed using standard cathode and anode materials such as MnO2/Carbon, PbO2, NiO, AgO and Zn. However, by using a solid polymer electrolyte composed of an ionic liquid and polyvinyl alcohol, novel types of solid state batteries are demonstrated with discharge voltages ranging up to 1.8 V, dependent upon the type of cathode and anode used. These batteries are characterized by ionic conductivity, initial voltage measurements, and discharge profiles.
Published: 2011

126. Brain dysfunctions during facial discrimination in schizophrenia: Selective association to affect decoding

Author: Junghee Lee, Armen Yerevanian, Javier Quintana, Tiffany Wong, Michael Marcus, and Kimmy S. Kee
Subjects: Adult, Male, media_common.quotation_subject, Neuroscience (miscellaneous), Neuropsychological Tests, Affect (psychology), behavioral disciplines and activities, Brain mapping, Functional Laterality, Discrimination, Psychological, Social cognition, Perception, medicine, Humans, Middle frontal gyrus, Radiology, Nuclear Medicine and imaging, media_common, Analysis of Variance, Brain Mapping, Facial expression, medicine.diagnostic_test, Brain, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Facial Expression, Psychiatry and Mental health, Pattern Recognition, Visual, Schizophrenia, Face, Female, Schizophrenic Psychology, Psychology, Functional magnetic resonance imaging, Neuroscience, Photic Stimulation
Abstract: Schizophrenia patients exhibit impaired facial affect perception, yet the exact nature of this impairment remains unclear. We investigated neural activity related to processing facial emotional and non-emotional information and complex images in 12 schizophrenia patients and 15 healthy controls using functional magnetic resonance imaging. All subjects performed a facial information processing task with three conditions: matching facial emotion, matching facial identity, and matching complex visual patterns. Patients and controls showed comparable behavioral performance in all task conditions. The neural activation patterns in schizophrenia patients and healthy controls were distinctly different while processing affect-related facial information but not other non-emotional facial features. During emotion matching, orbital frontal cortex and left amydala activations were found in controls but not in patients. When comparing emotion versus identity matching, controls activated the fusiform and middle temporal gyri, left superior temporal gyrus, and right inferior and middle frontal gyrus, whereas schizophrenia patients only activated the middle and inferior frontal gyri, the frontal operculi and the right insular cortex. Our findings suggest that schizophrenia patients and healthy controls may utilize different neural networks when processing facial emotional information.
Published: 2011

127. Cochrane in context: Combined and alternating paracetamol and ibuprofen therapy for febrile children

Author: Ian Maconochie, David W. Johnson, Antonia S Stang, Lisa Hartling, Anna M Thomsen, Tiffany Wong, and Heather Ganshorn
Subjects: medicine.medical_specialty, business.industry, Context (language use), General Medicine, Ibuprofen, Confidence interval, Acetaminophen, Surgery, law.invention, Randomized controlled trial, law, Internal medicine, Relative risk, Pediatrics, Perinatology and Child Health, medicine, Antipyretic, Adverse effect, business, medicine.drug
Abstract: Background Health-care professionals frequently recommend fever treatment regimens for children who either combine paracetamol and ibuprofen or alternate them.However, there is uncertainty about whether these regimens are better than using single agents and about the adverse effect profile of combination regimens. Objectives To assess the results and side effects of combining paracetamol and ibuprofen, or alternating them in consecutive treatments, compared with monotherapy for treating fever in children. Search methods In September 2013, we searched Cochrane Infectious Diseases Group Specialized Register; Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; LILACS and International Pharmaceutical Abstracts (2009-2011). Selection criteria We included randomized controlled trials that compared alternating or combined paracetamol and ibuprofen regimens with monotherapy in children with fever. Data collection and analysis One review author and two assistants independently screened the searches and applied the inclusion criteria. Two authors assessed risk of bias and graded the evidence independently. We conducted various analyses for different comparison groups (combined therapy versus monotherapy, alternating therapy versus monotherapy and combined therapy versus alternating therapy). Main results Six studies, enrolling 915 participants, are included. Compared to administering a single antipyretic alone, administering combined paracetamol and ibuprofen to febrile children can result in a lower mean temperature at 1 hour after treatment (mean difference -0.27 ∘C, 95% confidence interval -0.45 to -0.08, two trials, 163 participants, moderate quality evidence). If no further antipyretics are given, combined treatment probably also results in a lower mean temperature at 4 hours (mean difference -0.70 ∘C, 95% confidence interval -1.05 to -0.35, two trials, 196 participants, moderate quality evidence), and in fewer children remaining or becoming febrile for at least 4 hours after treatment (relative risk 0.08, 95% confidence interval 0.02 to 0.42, two trials, 196 participants, moderate quality evidence). Only one trial assessed a measure of child discomfort (fever, associated symptoms at 24 and 48 hours), but did not find a significant difference in this measure between the treatment regimens (one trial, 156 participants, evidence quality not graded). In practice, caregivers are often advised to initially provide a single agent (paracetamol or ibuprofen), and then provide a further dose of the alternative if the child;s fever fails to resolve or recurs. Giving alternating treatment in this manner may result in a lower mean temperature at 1 hour after the second dose (mean difference -0.60 ∘C, 95% confidence interval -0.94 to -0.26, two trials, 78 participants, low quality evidence), and may also result in fewer children remaining or becoming febrile for up to 3 hours after it is given (relative risk 0.25, 95% confidence interval 0.11 to 0.55, two trials, 109 participants, low quality evidence). One trial assessed child discomfort (mean pain scores at 24, 48 and 72 hours), finding that these mean scores were lower, with alternating therapy, despite fewer doses of antipyretic being given overall (one trial, 480 participants, low quality evidence) Only one small trial compared alternating therapy with combined therapy. No statistically significant differences were seen in mean temperature or in the number of febrile children at 1, 4 or 6 hours (one trial, 40 participants, very low quality evidence). In all the trials, there were no serious adverse events that were directly attributed to the medications used. Authors' conclusions There is some evidence that both alternating and combined antipyretic therapies may be more effective at reducing temperatures than monotherapy alone. However, the evidence for improvements in measures of child discomfort remains inconclusive. There is insufficient evidence to decide which of combined or alternating therapy might be more beneficial. Future research needs to measure child discomfort using standardized tools, and assess the safety of combined and alternating antipyretic therapies.
Published: 2014

128. Mg2+ Ion Behavior in Ionic Liquids

Author: Thomas E. Sutto, Jenna Taft, Teresa Duncan, and Tiffany Wong
Subjects: chemistry.chemical_compound, Chemistry, Inorganic chemistry, Ionic liquid, Ion
Abstract: The behavior of the Mg ion in ionic liquids is characterized in this paper. High ionic conductivity and electrochemical stability is observed for ionic liquids composed of a 1,2-dimethyl-3-n-R-imidazolium cation (R = propyl (MMPI) and butyl (MMBI)) and a bis(trifluoromethanesulfonyl)-imide (TFSI) anion containing Mg(TFSI)2. The ionic liquids containing the Mg ion are also used to create solid polymer gel electrolytes using PVdF-HFP. The ionic conductivity of the TFSI-based ionic liquids, in both liquid form and solid gel, ranges from 1-3 mS/cm at room temperature. Electrochemical measurements indicate that the Mg ion is readily intercalated and de-intercalated from graphite, with charge/discharge efficiencies typically above 80%. X-ray diffraction analysis indicates a difference of only 1 Aå in the c-axis expansion of the graphite when intercalated with the imidazolium cation or the Mg ion and the imidazolium cations. This indicates that co-intercalation of the Mg ion and the imidazolium cation is occurring.
Published: 2010

129. Synthesis and Characterization of Polymerized Ionic Liquids

Author: Tiffany Wong, Thomas E. Sutto, Jenna Taft, and Teresa Duncan
Subjects: chemistry.chemical_compound, Chemical engineering, Polymerization, Chemistry, Ionic liquid, Characterization (materials science)
Abstract: Polymerized ionic liquids are prepared using a dibromoalkane reacted with 2 methyl imidazole. Two different dibromoalkanes are used, 1,5-dibromopentane and 1,6-dibromohexane. In order to increase the molecular weight of these two polymers, two different synthetic attempts were used to create poly-(2-methyl-1-pentyl imidazolium bromide and poly-(2-methyl-1-hexyl imidazolium bromide) with molecular weights of 7400 and 8900. Anion exchanges are performed to replace the bromide with hexafluorophosphate. These polymers are then doped with LiPF6 in a solution of acetonitrile which was subsequently drop cast. Ionic conductivity measurements indicate ionic conductivity above 0.01 mS/cm, with no liquid electrolyte present.
Published: 2010

130. Supervised epinephrine autoinjector administration in a cohort of children with anaphylaxis during oral food challenges (OFCs)

Author: Timothy Teoh, Ingrid Baerg, Tracy Gonzalez, Tiffany Wong, Lianne Soller, Edmond S. Chan, and Kyla J. Hildebrand
Subjects: medicine.medical_specialty, business.industry, Immunology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Emergency medicine, Cohort, medicine, Immunology and Allergy, Epinephrine autoinjector, 030223 otorhinolaryngology, business, Administration (government), Anaphylaxis
Published: 2018

131. X-ray diffraction studies of electrochemical graphite intercalation compounds of ionic liquids

Author: Teresa Duncan, Thomas E. Sutto, and Tiffany Wong
Subjects: chemistry.chemical_compound, Tetrafluoroborate, chemistry, General Chemical Engineering, Hexafluorophosphate, Ionic liquid, Intercalation (chemistry), Inorganic chemistry, Electrochemistry, Ionic conductivity, Graphite, Imide
Abstract: Electrochemical intercalation studies are used to characterize a series of ionic liquids composed of a variety of cationic and anionic species. Electrochemically, the ionic liquids are characterized by cyclic voltammograms and charge–discharge experiments for the intercalation and de-intercalation of the various cationic and anionic species into graphite. X-ray structure analysis is also performed to determine the relationship between the electrochemical behaviour of the ionic liquids, and the formation of intercalated graphitic compounds. Two different types of imidazolium cations are studied, specifically the di- and trisubstituted imidazolium. These cations are paired with the following anions: tetrafluoroborate, hexafluorophosphate, bis(trifluoromethanesulfonyl)imide, bis(perfluoroethanesulfonyl)imide, nitrate and hydrogen sulfate. Results indicate stronger intercalation chemistry for the trisubstituted imidazoliums, correlating with the greater charge–discharge efficiencies found for these types of ionic liquids. Many of the anions exhibit very poor charge–discharge efficiencies, correlating to very poorly formed graphite intercalates. The exception to this is the hydrogen sulfate intercalate, which had low charge–discharge efficiencies but formed a well defined graphite intercalate. Only the imide based anions exhibited both high charge–discharge efficiencies and the formation of a clearly defined graphite intercalate.
Published: 2009

132. Review Essay– David Singh Grewal's Network Power: The Social Dynamics of Globalization (2008)

Author: Tiffany Wong
Subjects: Power (social and political), 03 medical and health sciences, Globalization, Social dynamics, 0302 clinical medicine, 05 social sciences, 030221 ophthalmology & optometry, Sociology, Neoclassical economics, Law, 050601 international relations, 0506 political science
Abstract: Networks have been discussed extensively in different ways within social and cultural theory as well as in economic scholarship. Author ofNetwork Power, David Singh Grewal, participates in a popular discourse by describing globalization as a series of networks of power in contemporary society. In the same year that his book was published, Grewal writes a response to these theories of a globalized “flat” society in an article for the UK newspaper,The Guardian.Entitled “The World Isn't Flat – It's Networked,” the preface reads: “Globalisation does not 'flatten opportunity in the world: rather it forces everyone to conform to an underlying standard, specifically that of the already privileged nation.” A young scholar, Grewal holds a J.D. from Yale Law School and is currently Ph.D. student at the Department of Government at Harvard University.
Published: 2009

133. Separation of human plasma proteins HSA and HIgG using high-capacity macroporous gel-filled membranes

Author: Raja Ghosh, Tiffany Wong, Elena N. Komkova, Ronald F. Childs, Dharmesh M. Kanani, and Alicja M. Mika
Subjects: Polypropylene, Environmental Engineering, Chromatography, Ion exchange, Biomedical Engineering, Bioengineering, Human serum albumin, Transport protein, chemistry.chemical_compound, Membrane, chemistry, medicine, Blood plasma fractionation, Ammonium, Binding site, Biotechnology, medicine.drug
Abstract: This paper discusses the separation of human serum albumin (HSA), the most abundant protein present in plasma from human immunoglobulin G (HIgG) by membrane chromatography using a novel macroporous gel-filled membrane (designated Q Type 2). The membrane was prepared by anchoring a quaternary ammonium salt macroporous gel within the pores of a non-woven, polypropylene fabric. Factors affecting HSA binding were examined and operating conditions suitable for separating it from human plasma were identified. At an optimized condition, the HSA binding capacity of this novel membrane under saturating conditions was in the range of 290–300 mg/ml. This was not only significantly higher than binding capacities reported for other chromatographic membranes, but also higher than binding capacities of conventional gel based chromatographic media. The protein binding capacity was also largely insensitive to the superficial velocity, indicating the dominance of convective protein transport to and from the binding sites. The suitability of using this membrane for plasma fractionation was demonstrated by the separation of a simulated feed solution consisting of HSA and HIgG.
Published: 2007

134. The Energy Spectrum of Cosmic Rays above 10$^{17.2}$ eV Measured by the Fluorescence Detectors of the Telescope Array Experiment in Seven Years

Author: K. Hibino, T. Goto, Grigory Rubtsov, H. Yoshii, Akitoshi Oshima, Ben Stokes, Kazumasa Kawata, R. Azuma, H. Kawai, K. Nagasawa, Kenta Yashiro, M. Abe, T.-A. Shibata, Gordon Thomson, Tom Stroman, Robert Cady, K. Martens, Federico R. Urban, Mayuko Minamino, T. Suzawa, John Belz, K. Honda, S. Kitamura, Hang Bae Kim, Priti Shah, Hideki Tanaka, Yasunori Kitamura, Mai Takamura, Hidemi Ito, Isaac Myers, K. Tsutsumi, Byung Gu Cheon, Masaaki Tanaka, Nobuyuki Sakurai, Bokkyun Shin, Eiji Kido, Fumiya Shibata, Igor Tkachev, Pierre Sokolsky, J. H. Kim, Kazuhiro Machida, Y. Tsunesada, Zach Zundel, S. Kawakami, Douglas Bergman, Fumio Kakimoto, R. Ishimori, K. Kasahara, Kanako Yamazaki, K. Oki, Toshiyuki Nonaka, J. P. Lundquist, M. Takeda, Sergey Troitsky, Inkyu Park, R. W. Springer, Shigehiro Nagataki, G. Vasiloff, Heungsu Shin, Y. Mukai, Y. J. Kwon, Hideyuki Ohoka, Hiroyuki Sagawa, Jyunsei Chiba, Y. Yoneda, Akimichi Taketa, Kiyoshi Tanaka, Dongsu Ryu, Hiroshi Yamaoka, N. Inoue, M. Ohnishi, Masaomi Ono, Ryuji Takeishi, S. Udo, C. C. H. Jui, Tomohiro Matsuda, S. B. Thomas, Toshihiro Fujii, Naoaki Hayashida, M. Allen, Shingo Kawana, O. Kalashev, W. R. Cho, Y. Uchihori, William Hanlon, Toru Nakamura, T. Okuda, J. Ogura, Kenichi Kadota, Takayuki Tomida, Elliott Barcikowski, Dmitri Ivanov, H. Tokuno, Takaaki Ishii, J. D. Smith, D. C. Rodriguez, J. Yang, Yuichiro Tameda, John N. Matthews, J. Lan, Masato Takita, Peter Tinyakov, Samuel Blake, Shoichi Ogio, L. M. Scott, A. Nozato, Y. Hayashi, Hideaki Shimodaira, Vladim Kuzmin, T. Matsuyama, S. Ozawa, Tareq Abu-Zayyad, R. Yamane, Maxim Pshirkov, Michiyuki Chikawa, S. Yoshida, Daisuke Ikeda, S. R. Stratton, Rasha Abbasi, Tiffany Wong, Masaki Fukushima, and R. Zollinger
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Range (particle radiation), 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Detector, FOS: Physical sciences, Astronomy and Astrophysics, Cosmic ray, Astrophysics, 7. Clean energy, 01 natural sciences, Fluorescence, law.invention, Telescope, Orders of magnitude (time), law, 0103 physical sciences, Energy spectrum, Astrophysics - High Energy Astrophysical Phenomena, 010303 astronomy & astrophysics, Energy (signal processing)
Abstract: The Telescope Array (TA) experiment is the largest detector to observe ultra-high-energy cosmic rays in the northern hemisphere. The fluorescence detectors at southern two stations of TA are newly constructed and have now completed seven years of steady operation. One advantage of monocular analysis of the fluorescence detectors is a lower energy threshold for cosmic rays than that of other techniques like stereoscopic observations or coincidences with the surface detector array, allowing the measurement of an energy spectrum covering three orders of magnitude in energy. Analyzing data collected during those seven years, we report the energy spectrum of cosmic rays covering a broad range of energies above 10$^{17.2}$ eV measured by the fluorescence detectors and a comparison with previously published results., Submitted to Astroparticle Physics
Published: 2015

135. Publisher’s Note: Measurement of the proton-air cross section with Telescope Array’s Middle Drum detector and surface array in hybrid mode [Phys. Rev. D92, 032007 (2015)]

Author: Hideki Tanaka, K. Nagasawa, R. Zollinger, Hisono Tokuno, L. M. Scott, Pierre Sokolsky, A. Nozato, Y. Hayashi, M. Takeda, Shigehiro Nagataki, K. Kawata, K. Hibino, Hidemi Ito, P. Tinyakov, Mai Takamura, Dmitri Ivanov, Rasha Abbasi, M. Takita, Inkyu Park, Daisuke Ikeda, S. R. Stratton, O. Kalashev, B. G. Cheon, Akitoshi Oshima, Y. Tsunesada, Kalen Martens, R. W. Springer, Hideaki Shimodaira, Tiffany Wong, T. Goto, Charlie Jui, Ryuji Takeishi, Maxim Pshirkov, Sergey Troitsky, Mayuko Minamino, Yuichiro Tameda, K. Oki, K. Honda, Masaki Fukushima, Shunsuke Ozawa, Grigory Rubtsov, K. Yamazaki, T.-A. Shibata, Yasunori Kitamura, J. D. Smith, Takeshi Okuda, Vladim Kuzmin, Gordon Thomson, Igor Tkachev, Tom Stroman, H. Yoshii, Masaaki Tanaka, Robert Cady, Fumiya Shibata, Tomohiro Matsuda, Taka Tomida, Akimichi Taketa, R. Ishimori, M. Allen, S. B. Thomas, S. Kawakami, T. Matsuyama, Bokkyun Shin, John Belz, G. Vasiloff, Tareq Abu-Zayyad, R. Yamane, J. Ogura, Eiji Kido, Kazuhiro Machida, Elliott Barcikowski, M. J. Chae, Hiroyuki Sagawa, Shingo Kawana, K. Kadota, Jyunsei Chiba, Dongsu Ryu, D. R. Bergman, Naoaki Hayashida, Heungsu Shin, Y. Uchihori, William Hanlon, S. Yoshida, Y. J. Kwon, Toshitsugu Fujii, J. Yang, K. Kasahara, Nobuyuki Sakurai, Hideyuki Ohoka, John N. Matthews, Samuel Blake, Shoichi Ogio, Kiyoshi Tanaka, Fumio Kakimoto, Zach Zundel, M. Abe, Y. Yoneda, N. Inoue, S. I. Lim, Masaomi Ono, W. R. Cho, J. H. Kim, M. Ohnishi, Takaaki Ishii, Ben Stokes, Hongsu Kim, Federico R. Urban, D. C. Rodriguez, T. Suzawa, Toru Nakamura, H. Kawai, Isaac Myers, S. Kitamura, Kenta Yashiro, K. Tsutsumi, Priti Shah, Toshiyuki Nonaka, Michiyuki Chikawa, Y. Mukai, Hiroshi Yamaoka, Shigeharu Udo, R. Azuma, J. P. Lundquist, and J. Lan
Subjects: Physics, Surface (mathematics), Nuclear and High Energy Physics, Proton, business.industry, Detector, Drum, Astrophysics, Cosmology, law.invention, Gravitation, Telescope, Cross section (physics), Optics, law, business
Published: 2015

136. Combined Autoimmune Cytopenias Presenting in Childhood

Author: Ibrahim, Al Ghaithi, Nicola A M, Wright, Vicky R, Breakey, Kelly, Cox, Ashley, Warias, Tiffany, Wong, Colleen, O'Connell, and Victoria, Price
Subjects: Male, Child, Preschool, Immunologic Deficiency Syndromes, Humans, Infant, Female, Child, Immunosuppressive Agents, Autoimmune Diseases, Retrospective Studies
Abstract: Pediatric patients with chronic and/or refractory autoimmune multi-lineage cytopenias present challenges in both diagnosis and management. Increasing availability of diagnostic testing has revealed an underlying immune dysfunction in patients previously diagnosed with Evans Syndrome. However, the data are sparse and the majority of patients are adults.We performed a retrospective chart review to document the natural history of 23 pediatric patients with autoimmune multi-lineage cytopenias followed at three tertiary care pediatric hematology clinics.Investigations revealed seven patients (30.4%) with an autoimmune lymphoproliferative-like syndrome and six patients (26.1%) with other primary immunodeficiencies. Only one (4.3%) patient was suspected to have systemic lupus erythematosus and six patients (26.1%) had other types of autoimmunity. Treatment consisted of immunosuppressive therapy, intravenous gammaglobulin, and splenectomy. Supportive care included granulocyte-colony stimulating factor, and blood product transfusions. Two patients (8.7%) died. Complete remission was achieved in 3 patients (13.0%); of the remaining, 14 patients (60.9%) had chronic immune thrombocytopenic purpura, 10 patients (43.5%) chronic autoimmune neutropenia, and 4 patients (17.4%) chronic autoimmune hemolytic anemia with a median follow up of 5 years (2 months-12 years).These data suggest that pediatric patients presenting with autoimmune multi-lineage cytopenias should undergo investigation for underlying immune dysregulation, including autoimmune lymphoproliferative syndrome, other primary immunodeficiencies and autoimmune disorders. The development of an international registry for such patients is imperative to improve the understanding of their complex natural history.
Published: 2015

137. Effect of module design on the efficiency of membrane chromatographic separation processes

Author: Raja Ghosh and Tiffany Wong
Subjects: Chromatography, Flow distribution, Filtration and Separation, Biochemistry, Capacity enhancement, chemistry.chemical_compound, Chromatographic separation, Adsorption, Membrane, chemistry, Binding efficiency, General Materials Science, Physical and Theoretical Chemistry, Lysozyme
Abstract: The efficiency of membrane chromatography is critically dependent on membrane module design. This paper discusses the vital role of fluid flow distribution and collection within a membrane module in membrane chromatographic processes. The performances of membrane modules of three different diameters based on a new design which enhanced both feed flow distribution and effluent collection were compared with corresponding conventional modules. Protein bioseparation being one of the major applications of membrane chromatography, these studies were carried out using lysozyme as test solute. The lysozyme binding capacities of cation-exchange membranes housed in the different modules were measured both in the breakthrough mode and in the pulse chromatographic mode. The membrane modules based on the new design showed significantly higher lysozyme binding capacities than the corresponding conventional modules. The binding capacity enhancement due to module design increased with increase in membrane diameter. With the largest diameter membrane module, the breakthrough binding capacity enhancements with the new design were in the range of 110–112%. With the same diameter membrane module the maximum binding capacity enhancements in the pulse chromatographic mode was found to be around 135%. The reasons for the increase in binding efficiency are explained.
Published: 2006

138. A quality improvement initiative to reduce low-value red blood cell transfusions in hospitalized oncology patients

Author: Tiffany Wong, Geoffrey D Bass, Jennifer S. Myers, Perry Harris Dubin, Michael Davenport, and Jason Wagner
Subjects: Rbc transfusion, Cancer Research, medicine.medical_specialty, Acute coronary syndrome, Gastrointestinal bleeding, Quality management, business.industry, 030503 health policy & services, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Oncology, Medical risk, medicine, Retrospective analysis, Oncology patients, 030212 general & internal medicine, 0305 other medical science, Intensive care medicine, business, Limited resources
Abstract: 116 Background: Red blood cell (RBC) transfusions are costly, a limited resource, and pose serious medical risk. While most disciplines now transfuse sparingly, hospitalized oncology patients at our institution are often transfused liberally. We conducted a QI initiative to reduce practice variation by adopting a standardized restrictive transfusion strategy. Methods: We performed a retrospective analysis of the total number of pre-transfusion hemoglobin-adjusted RBC transfusions from 02/2015 to 08/2015. Patients with severe gastrointestinal bleeding and acute coronary syndrome were excluded. Extensive feedback from providers was solicited and a comprehensive review of the evidence was performed to understand the process driving existing practices. This information and a root cause analysis were presented to key members of Oncology leadership to gain consensus on a RBC transfusion algorithm. The final algorithm recommended transfusing to a Hg goal of 8 g/dL if the platelet count was ≤ 50K; otherwise the Hg goal was 7 g/dL. We defined low-value RBC transfusions as a transfusion occurring outside the parameters of this algorithm. A multifaceted educational campaign comprising in-person meetings and web-based postings was launched to target ward nurses, advanced practitioners, residents, and attending physicians. RBC transfusions were then tracked to monitor adherence to the algorithm. Results: Analysis of the current process using QI methods found that RBC transfusion practices are most influenced by uncertainty of best practice and variation in attending preference. After the implementation of a RBC transfusion algorithm, the overall number of low-value RBC transfusions decreased from 29.6% to 19.7% (p < 0.001). This reduction was most marked in patients with platelet counts > 50K where there was a reduction from 78.7% to 55.6% (p < 0.001). A 9.9% overall reduction corresponds to roughly 520 fewer RBC transfusions per year, which suggests an annual estimated cost savings of $520,000. Conclusions: By using a standardized QI framework, we were able to successfully decrease variation in practice that results in low-value RBC transfusions in hospitalized oncology patients.
Published: 2017

139. Determinants of Quality of life (QOL) Among Children Undergoing Oral Food Challenge (OFC) in Canada

Author: Ingrid Baerg, Christopher Mill, Tracy Gonzalez, Edmond S. Chan, Timothy Teoh, Tiffany Wong, Lianne Soller, and Kyla J. Hildebrand
Subjects: Gerontology, Pediatrics, medicine.medical_specialty, Quality of life (healthcare), business.industry, Oral food challenge, Immunology, medicine, Immunology and Allergy, business
Published: 2017

140. IgE-Mediated allergy to wheat in a child with celiac disease – a case report

Author: Hin Hin Ko, Tiffany Wong, and Edmond S. Chan
Subjects: Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Allergy, business.industry, food and beverages, Case Report, General Medicine, Case presentation, Disease, medicine.disease, Immune system, Ige mediated, Concomitant, Immunology, Wheat, medicine, Immunology and Allergy, Celiac disease, business, Wheat allergy
Abstract: Introduction Celiac disease and immediate type hypersensitivity to wheat are immune responses with different pathogenic mechanisms. Both diseases are well known entities but their coexistence in the same patient is rarely reported. This is a unique case presentation of a patient with celiac disease who developed concomitant IgE-mediated wheat allergy and presented with immediate symptoms in two body systems. Case presentation We report the case of a girl with celiac disease who subsequently developed IgE-mediated hypersensitivity to wheat. The patient is a Caucasian female who was diagnosed with celiac disease at 18 months of age after presenting with recurrent vomiting and failure to thrive. Her anti-tTG antibody level was greater than 200 E.U. and biopsy results from endoscopy were consistent with celiac disease. Specific IgE antibody to wheat was negative at 2 years of age. Around seven years of age, she developed immediate symptoms of urticaria, cough and shortness of breath with accidental exposures to wheat. Specific IgE antibody testing was repeated and positive to wheat (42.5 kU/L), as well as rye (33.9 kU/L), barley (53.4 kU/L) and oat (11.3 kU/L). At 9 years of age, skin prick testing was positive to wheat, barley and rye but negative to oat. The patient has subsequently tolerated an open oral food challenge to oat. She continues to avoid wheat, rye and barley and carries an epinephrine autoinjector at all times. Conclusion To our knowledge, this is the first report of a patient with celiac disease and concomitant IgE-mediated allergy to wheat presenting with immediate symptoms in two body systems. Although the pathophysiology of these diseases is different, this case demonstrates that they are not exclusive of one another. In patients who develop unexplained symptoms consistent with IgE-mediated allergy, an allergy assessment should be considered.
Published: 2014

141. Cochrane in context: Combined and alternating paracetamol and ibuprofen therapy for febrile children

Author: Tiffany, Wong, Antonia S, Stang, Heather, Ganshorn, Lisa, Hartling, Ian K, Maconochie, Anna M, Thomsen, and David W, Johnson
Subjects: Antipyretics, Fever, Child, Preschool, Practice Guidelines as Topic, Humans, Drug Therapy, Combination, Ibuprofen, Child, Acetaminophen
Abstract: Health-care professionals frequently recommend fever treatment regimens for children who either combine paracetamol and ibuprofen or alternate them.However, there is uncertainty about whether these regimens are better than using single agents and about the adverse effect profile of combination regimens.To assess the results and side effects of combining paracetamol and ibuprofen, or alternating them in consecutive treatments, compared with monotherapy for treating fever in children.In September 2013, we searched Cochrane Infectious Diseases Group Specialized Register; Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; LILACS and International Pharmaceutical Abstracts (2009-2011).We included randomized controlled trials that compared alternating or combined paracetamol and ibuprofen regimens with monotherapy in children with fever.One review author and two assistants independently screened the searches and applied the inclusion criteria. Two authors assessed risk of bias and graded the evidence independently. We conducted various analyses for different comparison groups (combined therapy versus monotherapy, alternating therapy versus monotherapy and combined therapy versus alternating therapy).Six studies, enrolling 915 participants, are included. Compared to administering a single antipyretic alone, administering combined paracetamol and ibuprofen to febrile children can result in a lower mean temperature at 1 hour after treatment (mean difference -0.27 ∘C, 95% confidence interval -0.45 to -0.08, two trials, 163 participants, moderate quality evidence). If no further antipyretics are given, combined treatment probably also results in a lower mean temperature at 4 hours (mean difference -0.70 ∘C, 95% confidence interval -1.05 to -0.35, two trials, 196 participants, moderate quality evidence), and in fewer children remaining or becoming febrile for at least 4 hours after treatment (relative risk 0.08, 95% confidence interval 0.02 to 0.42, two trials, 196 participants, moderate quality evidence). Only one trial assessed a measure of child discomfort (fever, associated symptoms at 24 and 48 hours), but did not find a significant difference in this measure between the treatment regimens (one trial, 156 participants, evidence quality not graded). In practice, caregivers are often advised to initially provide a single agent (paracetamol or ibuprofen), and then provide a further dose of the alternative if the child;s fever fails to resolve or recurs. Giving alternating treatment in this manner may result in a lower mean temperature at 1 hour after the second dose (mean difference -0.60 ∘C, 95% confidence interval -0.94 to -0.26, two trials, 78 participants, low quality evidence), and may also result in fewer children remaining or becoming febrile for up to 3 hours after it is given (relative risk 0.25, 95% confidence interval 0.11 to 0.55, two trials, 109 participants, low quality evidence). One trial assessed child discomfort (mean pain scores at 24, 48 and 72 hours), finding that these mean scores were lower, with alternating therapy, despite fewer doses of antipyretic being given overall (one trial, 480 participants, low quality evidence) Only one small trial compared alternating therapy with combined therapy. No statistically significant differences were seen in mean temperature or in the number of febrile children at 1, 4 or 6 hours (one trial, 40 participants, very low quality evidence). In all the trials, there were no serious adverse events that were directly attributed to the medications used.There is some evidence that both alternating and combined antipyretic therapies may be more effective at reducing temperatures than monotherapy alone. However, the evidence for improvements in measures of child discomfort remains inconclusive. There is insufficient evidence to decide which of combined or alternating therapy might be more beneficial. Future research needs to measure child discomfort using standardized tools, and assess the safety of combined and alternating antipyretic therapies.
Published: 2014

142. Combined and alternating paracetamol and ibuprofen therapy for febrile children

Author: Tiffany, Wong, Antonia S, Stang, Heather, Ganshorn, Lisa, Hartling, Ian K, Maconochie, Anna M, Thomsen, and David W, Johnson
Subjects: Antipyretics, Time Factors, Fever, Child, Preschool, Anti-Inflammatory Agents, Non-Steroidal, Humans, Ibuprofen, Child, Drug Administration Schedule, Acetaminophen, Randomized Controlled Trials as Topic
Abstract: Health professionals frequently recommend fever treatment regimens for children that either combine paracetamol and ibuprofen or alternate them. However, there is uncertainty about whether these regimens are better than the use of single agents, and about the adverse effect profile of combination regimens.To assess the effects and side effects of combining paracetamol and ibuprofen, or alternating them on consecutive treatments, compared with monotherapy for treating fever in children.In September 2013, we searched Cochrane Infectious Diseases Group Specialized Register; Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; LILACS; and International Pharmaceutical Abstracts (2009-2011).We included randomized controlled trials comparing alternating or combined paracetamol and ibuprofen regimens with monotherapy in children with fever.One review author and two assistants independently screened the searches and applied inclusion criteria. Two authors assessed risk of bias and graded the evidence independently. We conducted separate analyses for different comparison groups (combined therapy versus monotherapy, alternating therapy versus monotherapy, combined therapy versus alternating therapy).Six studies, enrolling 915 participants, are included. Compared to giving a single antipyretic alone, giving combined paracetamol and ibuprofen to febrile children can result in a lower mean temperature at one hour after treatment (MD -0.27 °Celsius, 95% CI -0.45 to -0.08, two trials, 163 participants, moderate quality evidence). If no further antipyretics are given, combined treatment probably also results in a lower mean temperature at four hours (MD -0.70 °Celsius, 95% CI -1.05 to -0.35, two trials, 196 participants, moderate quality evidence), and in fewer children remaining or becoming febrile for at least four hours after treatment (RR 0.08, 95% CI 0.02 to 0.42, two trials, 196 participants, moderate quality evidence). Only one trial assessed a measure of child discomfort (fever associated symptoms at 24 hours and 48 hours), but did not find a significant difference in this measure between the treatment regimens (one trial, 156 participants, evidence quality not graded). In practice, caregivers are often advised to initially give a single agent (paracetamol or ibuprofen), and then give a further dose of the alternative if the child's fever fails to resolve or recurs. Giving alternating treatment in this way may result in a lower mean temperature at one hour after the second dose (MD -0.60 °Celsius, 95% CI -0.94 to -0.26, two trials, 78 participants, low quality evidence), and may also result in fewer children remaining or becoming febrile for up to three hours after it is given (RR 0.25, 95% CI 0.11 to 0.55, two trials, 109 participants, low quality evidence). One trial assessed child discomfort (mean pain scores at 24, 48 and 72 hours), finding that these mean scores were lower, with alternating therapy, despite fewer doses of antipyretic being given overall (one trial, 480 participants, low quality evidence) Only one small trial compared alternating therapy with combined therapy. No statistically significant differences were seen in mean temperature, or the number of febrile children at one, four or six hours (one trial, 40 participants, very low quality evidence). There were no serious adverse events in the trials that were directly attributed to the medications used.There is some evidence that both alternating and combined antipyretic therapy may be more effective at reducing temperatures than monotherapy alone. However, the evidence for improvements in measures of child discomfort remains inconclusive. There is insufficient evidence to know which of combined or alternating therapy might be more beneficial.Future research needs to measure child discomfort using standardized tools, and assess the safety of combined and alternating antipyretic therapy.
Published: 2014

143. Searches for Large-Scale Anisotropy in the Arrival Directions of Cosmic Rays Detected above Energy of $10^{19}$ eV at the Pierre Auger Observatory and the Telescope Array

Author: Telescope, Array, Pierre Auger Collaborations (Alexander Aab, Pedro, Abreu, Marco, Aglietta, Eun Joo Ahn, Imen Al Samarai, Ivone, Albuquerque, Ingomar, Allekotte, Jeff, Allen, Patrick, Allison, Alejandro, Almela, Jesus Alvarez Castillo, Jaime Alvarez Muñiz, Rafael Alves Batista, Michelangelo, Ambrosio, Amin, Aminaei, Luis, Anchordoqui, Sofia, Andringa, Carla, Aramo, Victor Manuel Aranda, Fernando, Arqueros, Hernán Gonzalo Asorey, Pedro, Assis, Julien, Aublin, Maximo, Ave, Michel, Avenier, Gualberto, Avila, Nafiun, Awal, Alina Mihaela Badescu, Barber, Kerri B., Julia, Bäuml, Colin, Baus, Jim, Beatty, Karl Heinz Becker, Bellido, Jose A., Corinne, Berat, Mario Edoardo Bertania, Xavier, Bertou, Peter, Biermann, Pierre, Billoir, Blaess, Simon G., Miguel, Blanco, Carla, Bleve, Hans, Blümer, Martina, Boháčová, Denise, Boncioli, Carla, Bonifazi, Raffaella, Bonino, Nataliia, Borodai, Jeffrey, Brack, Iliana, Brancus, Ariel, Bridgeman, Pedro, Brogueira, Brown, William C., Peter, Buchholz, Antonio, Bueno, Stijn, Buitink, Buscemi, Mario, Caballero Mora, Karen S., Barbara, Caccianiga, Lorenzo, Caccianiga, Marina, Candusso, Laurentiu, Caramete, Caruso, Rossella, Antonella, Castellina, Gabriella, Cataldi, Lorenzo, Cazon, Rosanna, Cester, Chavez, Alan G., Andrea, Chiavassa, Jose Augusto Chinellato, Jiri, Chudoba, Marco, Cilmo, Clay, Roger W., Giuseppe, Cocciolo, Roberta, Colalillo, Alan, Coleman, Laura, Collica, Maria Rita Coluccia, Ruben, Conceição, Fernando, Contreras, Cooper, Mathew J., Alain, Cordier, Stephane, Coutu, Corbin, Covault, James, Cronin, Alex, Curutiu, Richard, Dallier, Bruno, Daniel, Sergio, Dasso, Kai, Daumiller, Dawson, Bruce R., de Almeida, Rogerio M., Manlio De Domenico, de Jong, Sijbrand J., Joao de Mello Neto, Ivan De Mitri, Jaime de Oliveira, Vitor de Souza, Luis del Peral, Olivier, Deligny, Hans, Dembinski, Niraj, Dhital, Claudio Di Giulio, Armando Di Matteo, Johana Chirinos Diaz, Mary Lucia Díaz Castro, Francisco, Diogo, Carola, Dobrigkeit, Wendy, Docters, Juan Carlos D'Olivo, Alexei, Dorofeev, Qader Dorosti Hasankiadeh, Maria Teresa Dova, Jan, Ebr, Ralph, Engel, Martin, Erdmann, Mona, Erfani, Escobar, Carlos O., Joao, Espadanal, Alberto, Etchegoyen, Pedro Facal San Luis, Heino, Falcke, Fang, Ke, Glennys, Farrar, Anderson, Fauth, Norberto, Fazzini, Ferguson, Andrew P., Mateus, Fernandes, Brian, Fick, Juan Manuel Figueira, Alberto, Filevich, Andrej, Filipčič, Brendan, Fox, Octavian, Fratu, Uwe, Fröhlich, Benjamin, Fuchs, Toshihiro, Fujii, Romain, Gaior, Beatriz, García, Sayri Tupac Garcia Roca, Diego Garcia Gamez, Diego Garcia Pinto, Gianpaolo, Garilli, Alberto Gascon Bravo, Florian, Gate, Hartmut, Gemmeke, Piera Luisa Ghia, Ugo, Giaccari, Marco, Giammarchi, Maria, Giller, Christian, Glaser, Henry, Glass, Mariano Gómez Berisso, Gómez Vitale, Primo F., Patrícia, Gonçalves, Gonzalez, Javier G., Nicolás, González, Ben, Gookin, Jacob, Gordon, Alessio, Gorgi, Peter, Gorham, Philippe, Gouffon, Stefan, Grebe, Nathan, Griffith, Aurelio, Grillo, Grubb, Trent D., Fausto, Guarino, Germano, Guedes, Matías Rolf Hampel, Patricia, Hansen, Diego, Harari, Harrison, Thomas A., Sebastian, Hartmann, John, Harton, Andreas, Haungs, Thomas, Hebbeker, Dieter, Heck, Philipp, Heimann, Herve, Alexander E., Hill, Gary C., Carlos, Hojvat, Nicholas, Hollon, Ewa, Holt, Piotr, Homola, Jörg, Hörandel, Pavel, Horvath, Miroslav, Hrabovský, Daniel, Huber, Tim, Huege, Antonio, Insolia, Paula Gina Isar, Ingolf, Jandt, Stefan, Jansen, Cecilia, Jarne, Mariela, Josebachuili, Alex, Kääpä, Olga, Kambeitz, Karl Heinz Kampert, Peter, Kasper, Igor, Katkov, Balazs, Kégl, Bianca, Keilhauer, Azadeh, Keivani, Ernesto, Kemp, Roger, Kieckhafer, Hans, Klages, Matthias, Kleifges, Jonny, Kleinfeller, Raphael, Krause, Nicole, Krohm, Oliver, Krömer, Daniel Kruppke Hansen, Daniel, Kuempel, Norbert, Kunka, Danielle, Lahurd, Luca, Latronico, Robert, Lauer, Markus, Lauscher, Pascal, Lautridou, Sandra Le Coz, Milton, Leão, Didier, Lebrun, Paul, Lebrun, Marcelo Augusto Leigui de Oliveira, Antoine Letessier Selvon, Isabelle Lhenry Yvon, Katrin, Link, Rebeca, López, Angeles Lopez Agüera, Karim, Louedec, Julio Lozano Bahilo, Lu, Lu, Agustin, Lucero, Marianne, Ludwig, Max, Malacari, Simone, Maldera, Manuela, Mallamaci, Jennifer, Maller, Dusan, Mandat, Paul, Mantsch, Analisa, Mariazzi, Vincent, Marin, Ioana, Mariş, Giovanni, Marsella, Daniele, Martello, Lilian, Martin, Humberto, Martinez, Oscar Martínez Bravo, Diane, Martraire, Jimmy Masías Meza, Hermann Josef Mathes, Sebastian, Mathys, James, Matthews, John, Matthews, Giorgio, Matthiae, Detlef, Maurel, Daniela, Maurizio, Eric, Mayotte, Peter, Mazur, Carlos, Medina, Gustavo Medina Tanco, Rebecca, Meissner, Maximilien, Melissas, Diego, Melo, Alexander, Menshikov, Stefano, Messina, Rishi, Meyhandan, Saša, Mićanović, Maria Isabel Micheletti, Lukas, Middendorf, Minaya, Ignacio A., Lino, Miramonti, Bogdan, Mitrica, Laura Molina Bueno, Silvia, Mollerach, Maria, Monasor, Delphine Monnier Ragaigne, François, Montanet, Carlo, Morello, Miguel, Mostafá, Moura, Celio A., Marcio Aparecido Muller, Gero, Müller, Sarah, Müller, Moritz, Münchmeyer, Roberto, Mussa, Gianni, Navarra, Sergio, Navas, Petr, Necesal, Lukas, Nellen, Anna, Nelles, Jens, Neuser, Nguyen, Phong H., Marcus, Niechciol, Lukas, Niemietz, Tim, Niggemann, Dave, Nitz, Dalibor, Nosek, Vladimir, Novotny, Lyberis, Nožka, Livingstone, Ochilo, Angela, Olinto, Micael, Oliveira, Noelia, Pacheco, Daniel Pakk Selmi Dei, Miroslav, Palatka, Juan, Pallotta, Nunzia, Palmieri, Philipp, Papenbreer, Gonzalo, Parente, Alejandra, Parra, Thomas, Paul, Miroslav, Pech, Jan, Pękala, Rodrigo, Pelayo, Iuri, Pepe, Lorenzo, Perrone, Emily, Petermann, Christine, Peters, Sergio, Petrera, Yevgeniy, Petrov, Jamyang, Phuntsok, Ricardo, Piegaia, Tanguy, Pierog, Pablo, Pieroni, Mário, Pimenta, Valerio, Pirronello, Manuel, Platino, Matthias, Plum, Alessio, Porcelli, Czeslaw, Porowski, Raul Ribeiro Prado, Paolo, Privitera, Michael, Prouza, Victor, Purrello, Quel, Eduardo J., Sven, Querchfeld, Sean, Quinn, Julian, Rautenberg, Olivier, Ravel, Diego, Ravignani, Benoît, Revenu, Jan, Ridky, Simone, Riggi, Markus, Risse, Pablo, Ristori, Vincenzo, Rizi, Washington Rodrigues de Carvalho, Iago Rodriguez Cabo, Gonzalo Rodriguez Fernandez, Jorge Rubén Rodriguez Rojo, Maria Dolores Rodríguez Frías, Dmytro, Rogozin, Germán, Ros, Jaime, Rosado, Tomas, Rossler, Markus, Roth, Esteban, Roulet, Adrian, Rovero, Saffi, Steven J., Alexandra, Saftoiu, Francesco, Salamida, Humberto, Salazar, Ahmed, Saleh, Francisco Salesa Greus, Gaetano, Salina, Federico, Sánchez, Patricia Sanchez Lucas, Santo, Catarina E., Edivaldo Moura Santos, Eva, Santos, Fred, Sarazin, Biswaijt, Sarkar, Raul, Sarmento, Ricardo, Sato, Nils, Scharf, Viviana, Scherini, Harald, Schieler, Peter, Schiffer, David, Schmidt, Olaf, Scholten, Harm, Schoorlemmer, Petr, Schovánek, Alexander, Schulz, Johannes, Schulz, Johannes, Schumacher, Sergio, Sciutto, Alberto, Segreto, Mariangela, Settimo, Amir, Shadkam, Shellard, Ronald C., Iván, Sidelnik, Guenter, Sigl, Octavian, Sima, Andrzej, Śmiałkowski, Radomir, Šmída, Gregory, Snow, Paul, Sommers, Sorokin, J., Ruben, Squartini, Srivastava, Yogendra N., Samo, Stanič, James, Stapleton, Jaroslaw, Stasielak, Maurice, Stephan, Anne, Stutz, Federico, Suarez, Tiina, Suomijärvi, Daniel Supanitsky, A., Michael, Sutherland, John, Swain, Zbigniew, Szadkowski, Marek, Szuba, Oscar Alejandro Taborda, Alex, Tapia, Mathieu, Tartare, Andreas, Tepe, Vanessa Menezes Theodoro, Charles, Timmermans, Todero Peixoto, Carlos J., Gabriel, Toma, Lenka, Tomankova, Bernardo, Tomé, Aurelio, Tonachini, Guillermo Torralba Elipe, Diego Torres Machado, Petr, Travnicek, Enrica, Trovato, Matias, Tueros, Ralf, Ulrich, Michael, Unger, Martin, Urban, Valdés Galicia, Jose F., Ines, Valiño, Laura, Valore, Guus van Aar, Patrick van Bodegom, van den Berg, Ad M., Sjoert van Velzen, Arjen van Vliet, Enrique, Varela, Bernardo Vargas Cárdenas, Gary, Varner, Vázquez, Jose R., Ricardo, Vázquez, Darko, Veberič, Valerio, Verzi, Jakub, Vicha, Mariela, Videla, Luis, Villaseñor, Brian, Vlcek, Serguei, Vorobiov, Hernan, Wahlberg, Oscar, Wainberg, David, Walz, Alan, Watson, Marc, Weber, Klaus, Weidenhaupt, Andreas, Weindl, Felix, Werner, Allan, Widom, Lawrence, Wiencke, Barbara, Wilczyńska, Henryk, Wilczyński, Martin, Will, Christopher, Williams, Tobias, Winchen, David, Wittkowski, Brian, Wundheiler, Sarka, Wykes, Tokonatsu, Yamamoto, Tolga, Yapici, Guofeng, Yuan, Alexey, Yushkov, Bruno, Zamorano, Enrique, Zas, Danilo, Zavrtanik, Marko, Zavrtanik, Ingyin, Zaw, Arnulfo, Zepeda, Jing, Zhou, Yue, Zhu, Marcelo Zimbres Silva, Michael, Ziolkowski, Francesca, Zuccarello, Rasha, Abbasi, Michihiko, Abe, Tareq Abu Zayyad, Monica, Allen, Robyn, Anderson, Ryuji, Azuma, Elliott, Barcikowski, Belz, John W., Bergman, Douglas R., Samuel Adam Blake, Robert, Cady, Min Jung Chae, Byung Gu Cheon, Junsei, Chiba, Michiyuki, Chikawa, Woo Ram Cho, Masaki, Fukushima, Takashi, Goto, William, Hanlon, Yoshio, Hayashi, Naoaki, Hayashida, Kinya, Hibino, Ken, Honda, Daisuke, Ikeda, Naoya, Inoue, Takaaki, Ishii, Rie, Ishimori, Hideo Ito (Utah, U., Riken, Dmitri, Ivanov, Jui, Charles C. H., Kenichi, Kadota, Fumio, Kakimoto, Oleg, Kalashev, Katsuaki, Kasahara, Hideyuki, Kawai, Saburo, Kawakami, Shingo, Kawana, Kazumasa, Kawata, Eiji, Kido, Hang Bae Kim, Ji Hee Kim, Ji Hyun Kim, Seiji, Kitamura, Yuki, Kitamura, Vadim, Kuzmin, Young Joon Kwon, Jian, Lan, Sun In Lim, Jon Paul Lundquist, Kazuhiro, Machida, Kai, Martens, Takeshi, Matsuda, Toshio, Matsuyama, Matthews, John N., Mayuko, Minamino, Keijiro, Mukai, Isaac, Myers, Keisuke, Nagasawa, Shigehiro, Nagataki, Toru, Nakamura, Toshiyuki, Nonaka, Asuka, Nozato, Shoichi, Ogio, Jun, Ogura, Munehiro, Ohnishi, Hideyuki, Ohoka, Kaoru, Oki, Takeshi, Okuda, Masaomi, Ono, Akitoshi, Oshima, Shunsuke, Ozawa, Park, Il H., Pshirkov, Maxim S., Douglas Chase Rodriguez, Grigory, Rubtsov, Dongsu, Ryu, Hiroyuki, Sagawa, Nobuyuki, Sakurai, Sampson, Amanda L., Scott, Lauren M., Priti Dhanesh Shah, Fumiya, Shibata, Tatsunobu, Shibata, Hideaki, Shimodaira, Bok Kyun Shin, Smith, Jeremy D., Pierre, Sokolsky, Wayne Springer, R., Benjamin Taylor Stokes, Stratton, Sean R., Thomas, Stroman, Takumi, Suzawa, Mai, Takamura, Masahiro, Takeda, Ryuji, Takeishi, Akimichi, Taketa, Masato, Takita, Yuichiro, Tameda, Hideki, Tanaka, Koichi, Tanaka, Manobu, Tanaka, Thomas, Stanton B., Thomson, Gordon B., Peter, Tinyakov, Igor, Tkachev, Hisao, Tokuno, Takayuki, Tomida, Sergey, Troitsky, Yoshiki, Tsunesada, Kazuki, Tsutsumi, Yukio, Uchihori, Shigeharu, Udo, Federico, Urban, Gina, Vasiloff, Tiffany, Wong, Hiroshi, Yamaoka, Katsuya, Yamazaki, Jongmann, Yang, Kenta, Yashiro, Shigeru, Yoshida, Hisashi, Yoshii, Rhett, Zollinger, Zachary, Zundel, Shogo, Konishi, Shingo, Wachi, Yoshiki, Nishimoto, Heungsu, Shin, Mai, Tsujimoto, Tomoya, Matsuhira, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Unité Scientifique de la Station de Nançay (USN), Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), PIERRE AUGER, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), A., Aab, P., Abreu, M., Aglietta, E. J., Ahn, I., Al Samarai, I. F. M., Albuquerque, I., Allekotte, J., Allen, P., Allison, A., Almela, J., Alvarez Castillo, J., Alvarez Mu?iz, R., Alves Batista, M., Ambrosio, A., Aminaei, L., Anchordoqui, S., Andringa, Aramo, Carla, F., Arquero, H., Asorey, P., Assi, J., Aublin, M., Ave, M., Avenier, G., Avila, A. M., Badescu, K. B., Barber, J., B?uml, C., Bau, J. J., Beatty, K. H., Becker, J. A., Bellido, C., Berat, M. E., Bertaina, X., Bertou, P. L., Biermann, P., Billoir, M., Blanco, C., Bleve, H., Bl?mer, M., Boh??ov?, D., Boncioli, C., Bonifazi, R., Bonino, N., Borodai, J., Brack, I., Brancu, P., Brogueira, W. C., Brown, P., Buchholz, A., Bueno, S., Buitink, Buscemi, Mario, K. S., Caballero Mora, B., Caccianiga, L., Caccianiga, M., Candusso, L., Caramete, R., Caruso, A., Castellina, G., Cataldi, L., Cazon, R., Cester, A. G., Chavez, A., Chiavassa, J. A., Chinellato, J., Chudoba, Cilmo, Marco, R. W., Clay, G., Cocciolo, Colalillo, Roberta, A., Coleman, L., Collica, M. R., Coluccia, R., Concei??o, F., Contrera, M. J., Cooper, A., Cordier, S., Coutu, C. E., Covault, J., Cronin, A., Curutiu, R., Dallier, B., Daniel, S., Dasso, K., Daumiller, B. R., Dawson, R. M., de Almeida, M., De Domenico, S. J., de Jong, J. R. T., de Mello Neto, I., De Mitri, J., de Oliveira, V., de Souza, L., del Peral, O., Deligny, H., Dembinski, N., Dhital, C., Di Giulio, A., Di Matteo, J. C., Diaz, M. L., D?az Castro, F., Diogo, C., Dobrigkeit, W., Docter, J. C., D'Olivo, A., Dorofeev, Q., Dorosti Hasankiadeh, M. T., Dova, J., Ebr, R., Engel, M., Erdmann, M., Erfani, C. O., Escobar, J., Espadanal, A., Etchegoyen, P., Facal San Lui, H., Falcke, K., Fang, G., Farrar, A. C., Fauth, N., Fazzini, A. P., Ferguson, M., Fernande, B., Fick, J. M., Figueira, A., Filevich, A., Filip?i?, B. D., Fox, O., Fratu, U., Fr?hlich, B., Fuch, T., Fuji, R., Gaior, B., Garc?a, S. T., Garcia Roca, D., Garcia Gamez, D., Garcia Pinto, G., Garilli, A., Gascon Bravo, F., Gate, H., Gemmeke, P. L., Ghia, U., Giaccari, M., Giammarchi, M., Giller, C., Glaser, H., Gla, M., G?mez Berisso, P. F., G?mez Vitale, P., Gon?alve, J. G., Gonzalez, N., Gonz?lez, B., Gookin, A., Gorgi, P., Gorham, P., Gouffon, S., Grebe, N., Griffith, A. F., Grillo, T. D., Grubb, Y., Guardincerri, Guarino, Fausto, G. P., Guede, M. R., Hampel, P., Hansen, D., Harari, T. A., Harrison, S., Hartmann, J. L., Harton, A., Haung, T., Hebbeker, D., Heck, P., Heimann, A. E., Herve, G. C., Hill, C., Hojvat, N., Hollon, E., Holt, P., Homola, J. R., H?randel, P., Horvath, M., Hrabovsk?, D., Huber, T., Huege, A., Insolia, P. G., Isar, K., Islo, I., Jandt, S., Jansen, C., Jarne, M., Josebachuili, A., K??p?, O., Kambeitz, K. H., Kampert, P., Kasper, I., Katkov, B., K?gl, B., Keilhauer, A., Keivani, E., Kemp, R. M., Kieckhafer, H. O., Klage, M., Kleifge, J., Kleinfeller, R., Krause, N., Krohm, O., Kr?mer, D., Kruppke Hansen, D., Kuempel, N., Kunka, G., La Rosa, D., Lahurd, L., Latronico, R., Lauer, M., Lauscher, P., Lautridou, S., Le Coz, M. S. A. B., Le?o, D., Lebrun, P., Lebrun, M. A., Leigui de Oliveira, A., Letessier Selvon, I., Lhenry Yvon, K., Link, R., L?pez, A., Lopez Ag?era, K., Louedec, J., Lozano Bahilo, L., Lu, A., Lucero, M., Ludwig, M. C., Maccarone, M., Malacari, S., Maldera, M., Mallamaci, J., Maller, D., Mandat, P., Mantsch, A. G., Mariazzi, V., Marin, I. C., Mari?, G., Marsella, D., Martello, L., Martin, H., Martinez, O., Mart?nez Bravo, D., Martraire, J. J., Mas?as Meza, H. J., Mathe, S., Mathy, J. A. J., Matthew, J., Matthew, G., Matthiae, D., Maurel, D., Maurizio, E., Mayotte, P. O., Mazur, C., Medina, G., Medina Tanco, M., Melissa, D., Melo, E., Menichetti, A., Menshikov, S., Messina, R., Meyhandan, S., Mi?anovi?, M. I., Micheletti, L., Middendorf, I. A., Minaya, L., Miramonti, B., Mitrica, L., Molina Bueno, S., Mollerach, M., Monasor, D., Monnier Ragaigne, F., Montanet, C., Morello, M., Mostaf?, C. A., Moura, M. A., Muller, G., M?ller, M., M?nchmeyer, R., Mussa, G., Navarra, S., Nava, P., Necesal, L., Nellen, A., Nelle, J., Neuser, M., Niechciol, L., Niemietz, T., Niggemann, D., Nitz, D., Nosek, V., Novotny, L., No?ka, L., Ochilo, A., Olinto, M., Oliveira, N., Pacheco, D., Pakk Selmi Dei, M., Palatka, J., Pallotta, N., Palmieri, P., Papenbreer, G., Parente, A., Parra, T., Paul, M., Pech, J., P?kala, R., Pelayo, I. M., Pepe, L., Perrone, R., Pesce, E., Petermann, C., Peter, S., Petrera, A., Petrolini, Y., Petrov, J., Phuntsok, R., Piegaia, T., Pierog, P., Pieroni, M., Pimenta, V., Pirronello, M., Platino, M., Plum, A., Porcelli, C., Porowski, R. R., Prado, P., Privitera, M., Prouza, V., Purrello, E. 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Horvath, M. Hrabovský, D. Huber, T. Huege, A. Insolia, P. G. Isar, K. Islo, I. Jandt, S. Jansen, C. Jarne, M. Josebachuili, A. Kääpä, O. Kambeitz, K. H. Kampert, P. Kasper, I. Katkov, B. Kégl, B. Keilhauer, A. Keivani, E. Kemp, R. M. Kieckhafer, H. O. Klage, M. Kleifge, J. Kleinfeller, R. Krause, N. Krohm, O. Krömer, D. Kruppke-Hansen, D. Kuempel, N. Kunka, G. L. Rosa, D. LaHurd, L. Latronico, R. Lauer, M. Lauscher, P. Lautridou, S. L. Coz, M. S. A., D. Lebrun, P. Lebrun, M. A. Leigui, A. Letessier-Selvon, I. Lhenry-Yvon, K. Link, R. López, A. L. Agüera, K. Louedec, J. L. Bahilo, L. Lu, A. Lucero, M. Ludwig, M. C. Maccarone, M. Malacari, S. Maldera, M. Mallamaci, J. Maller, D. Mandat, P. Mantsch, A. G. Mariazzi, V. Marin, I. C. Mariş, G. Marsella, D. Martello, L. Martin, H. Martinez, O. M. Bravo, D. Martraire, J. J. Masía, H. J. Mathe, S. Mathy, J. A. J., J. Matthew, G. Matthiae, D. Maurel, D. Maurizio, E. Mayotte, P. O. Mazur, C. Medina, G. Medina-Tanco, M. Melissa, D. Melo, E. 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Honda, D. Ikeda, N. Inoue, T. Ishii, R. Ishimori, H. Ito, D. Ivanov, C. C. H., K. Kadota, F. Kakimoto, O. Kalashev, K. Kasahara, H. Kawai, S. Kawakami, S. Kawana, K. Kawata, E. Kido, H. B. Kim, J. H. Kim, S. Kitamura, Y. Kitamura, V. Kuzmin, Y. J. Kwon, J. Lan, S. I. Lim, J. P. Lundquist, K. Machida, K. Marten, T. Matsuda, T. Matsuyama, J. N. Matthew, M. Minamino, K. Mukai, I. Myer, K. Nagasawa, S. Nagataki, T. Nakamura, T. Nonaka, A. Nozato, S. Ogio, J. Ogura, M. Ohnishi, H. Ohoka, K. Oki, T. Okuda, M. Ono, A. Oshima, S. Ozawa, I. H. Park, M. S. Pshirkov, D. C. Rodriguez, G. Rubtsov, D. Ryu, H. Sagawa, N. Sakurai, A. L. Sampson, L. M. Scott, P. D. Shah, F. Shibata, T. Shibata, H. Shimodaira, B. K. Shin, J. D. Smith, P. Sokolsky, R. W. Springer, B. T. Stoke, S. R. Stratton, T. A. Stroman, T. Suzawa, M. Takamura, M. Takeda, R. Takeishi, A. Taketa, M. Takita, Y. Tameda, H. Tanaka, K. Tanaka, M. Tanaka, S. B. Thoma, G. B. Thomson, P. Tinyakov, I. Tkachev, H. Tokuno, T. Tomida, S. Troitsky, Y. Tsunesada, K. Tsutsumi, Y. Uchihori, S. Udo, F. Urban, G. Vasiloff, T. Wong, R. Yamane, H. Yamaoka, K. Yamazaki, J. Yang, K. Yashiro, Y. Yoneda, S. Yoshida, H. Yoshii, R. Zollinger, Z. Zundel, T. T. Array, and Research unit Astroparticle Physics
Subjects: Ciencias Físicas, Astronomy, Rays, Astrophysics, Astroparticle physics, Cosmic rays, 01 natural sciences, law.invention, Pierre, law, Anisotropy, Telescope, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, [PHYS]Physics [physics], Energy, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Astrophysics::Instrumentation and Methods for Astrophysics, astroparticle physic, Radiación cósmica, Auger, Cosmic, Arrival, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, CIENCIAS NATURALES Y EXACTAS, High, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Cosmic ray, SURFACE DETECTOR, ICECUBE, AIR-SHOWER ARRAY, Directions, cosmic rays, 0103 physical sciences, Instrumentation and Methods for Astrophysics (astro-ph.IM), Ciencias Exactas, Pierre Auger Observatory, SPECTRUM, 010308 nuclear & particles physics, Array, Spectral density, Spherical harmonics, Física, Astronomy and Astrophysics, ASTROFÍSICA, Ultra, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astronomía, Dipole, RESOLUTION, Space and Planetary Science, Experimental High Energy Physics, Quadrupole, Observatory, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Spherical harmonic moments are well-suited for capturing anisotropy at any scale in the flux of cosmic rays. An unambiguous measurement of the full set of spherical harmonic coefficients requires full-sky coverage. This can be achieved by combining data from observatories located in both the northern and southern hemispheres. To this end, a joint analysis using data recorded at the Telescope Array and the Pierre Auger Observatory above 1019 eV is presented in this work. The resulting multipolar expansion of the flux of cosmic rays allows us to perform a series of anisotropy searches, and in particular to report on the angular power spectrum of cosmic rays above 1019 eV. No significant deviation from isotropic expectations is found throughout the analyses performed. Upper limits on the amplitudes of the dipole and quadrupole moments are derived as a function of the direction in the sky, varying between 7% and 13% for the dipole and between 7% and 10% for a symmetric quadrupole., Facultad de Ciencias Exactas
Published: 2014

144. Study of Ultra-High Energy Cosmic Ray Composition Using Telescope Array's Middle Drum Detector and Surface Array in Hybrid Mode

Author: J. D. Smith, Michiyuki Chikawa, Hideaki Shimodaira, Y. J. Kwon, Hideyuki Ohoka, Mayuko Minamino, Inkyu Park, K. Honda, Yasunori Kitamura, Igor Tkachev, Douglas Bergman, Kazumasa Kawata, R. Azuma, Masaaki Tanaka, S. Kitamura, Hidemi Ito, Rasha Abbasi, K. Yamazaki, Tareq Abu-Zayyad, R. Yamane, Hiroyuki Sagawa, Vladim Kuzmin, K. Martens, K. Oki, T. Goto, M. J. Chae, Y. Yoneda, N. Inoue, S. I. Lim, M. Ohnishi, Nobuyuki Sakurai, Takahiro Fujii, J. H. Kim, T.-A. Shibata, Gordon Thomson, S. Udo, C. C. H. Jui, Tom Stroman, Robert Cady, Elliott Barcikowski, Grigory Rubtsov, F. Kakimoto, L. M. Scott, S. B. Thomas, Kenta Yashiro, Dmitri Ivanov, A. Nozato, Y. Hayashi, Sergey Troitsky, H. Yoshii, Masato Takita, Akimichi Taketa, Bokkyun Shin, Mai Takamura, Fumiya Shibata, R. W. Springer, M. Abe, Takayuki Tomida, B. G. Cheon, R. Ishimori, R. Zollinger, A. L. Sampson, S. Yoshida, Tomohiro Matsuda, S. Kawakami, Zach Zundel, J. P. Lundquist, J. Yang, Hideki Tanaka, G. Vasiloff, Yoshiki Tsunesada, T. Matsuyama, Daisuke Ikeda, Hongsu Kim, J. Lan, Jyunsei Chiba, Dongsu Ryu, S. R. Stratton, K. Hibino, Tiffany Wong, Masaki Fukushima, Federico R. Urban, Takaaki Ishii, Peter Tinyakov, Samuel Blake, Shoichi Ogio, Maxim Pshirkov, K. Kasahara, Priti Shah, D. C. Rodriguez, Akitoshi Oshima, Masaomi Ono, Shunsuke Ozawa, Naoaki Hayashida, Toshiyuki Nonaka, T. Suzawa, Robert M. Anderson, Oleg Kalashev, W. R. Cho, K. Nagasawa, Y. Mukai, Hiroshi Yamaoka, Toru Nakamura, Isaac Myers, Kiyoshi Tanaka, Kenichi Kadota, Shingo Kawana, William Hanlon, T. Okuda, Y. Uchihori, H. Tokuno, Heungsu Shin, Ryuji Takeishi, M. Allen, Yuichiro Tameda, John N. Matthews, H. Kawai, John Belz, Eiji Kido, Kazuhiro Machida, K. Tsutsumi, Pierre Sokolsky, M. Takeda, Shigehiro Nagataki, J. Ogura, and B. T. Stokes
Subjects: Physics, Pierre Auger Observatory, High Energy Astrophysical Phenomena (astro-ph.HE), Resolution (electron density), Detector, FOS: Physical sciences, Astronomy and Astrophysics, Cosmic ray, Astrophysics, Auger, law.invention, Computational physics, Telescope, Observatory, law, Ultra-high-energy cosmic ray, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract: Previous measurements of the composition of Ultra-High Energy Cosmic Rays(UHECRs) made by the High Resolution Fly's Eye(HiRes) and Pierre Auger Observatory(PAO) are seemingly contradictory, but utilize different detection methods, as HiRes was a stereo detector and PAO is a hybrid detector. The five year Telescope Array(TA) Middle Drum hybrid composition measurement is similar in some, but not all, respects in methodology to PAO, and good agreement is evident between data and a light, largely protonic, composition when comparing the measurements to predictions obtained with the QGSJetII-03 and QGSJet-01c models. These models are also in agreement with previous HiRes stereo measurements, confirming the equivalence of the stereo and hybrid methods. The data is incompatible with a pure iron composition, for all models examined, over the available range of energies. The elongation rate and mean values of Xmax are in good agreement with Pierre Auger Observatory data. This analysis is presented using two methods: data cuts using simple geometrical variables and a new pattern recognition technique., Comment: 23 pages, 30 figures
Published: 2014
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145. Upper limit on the flux of photons with energies above1019 eVusing the Telescope Array surface detector

Author: S. Kitamura, K. Kasahara, B. G. Cheon, John Belz, T. Shirahama, Y. Murano, T. Iguchi, X. Zhou, H. Kawai, Maxim Pshirkov, W. R. Cho, Fumiya Shibata, M. Tanaka, K. Nagasawa, Y. Yoneda, N. Inoue, S. I. Lim, M. Ohnishi, R. Ishimori, Y. Kondo, K. Martens, Hideki Tanaka, R. Azuma, T. Matsuura, A. L. Sampson, S. Udo, K. Oki, Yasuhiro H. Takahashi, H. Ukai, Priti Shah, Ben Stokes, K. Kuramoto, Grigory Rubtsov, Zach Zundel, M. Wood, Peter Tinyakov, Samuel Blake, L. M. Scott, H. Yoshii, S. B. Thomas, S. W. Nam, Shoichi Ogio, Toru Nakamura, Y. Uchihori, E. J. Cho, Y. Hayashi, S. Y. Roh, Nobuyuki Sakurai, Naoaki Hayashida, R. Zollinger, Kenichi Kadota, T. Kanbe, Michiyuki Chikawa, S. Iwamoto, S. Kawakami, Robert M. Anderson, J. H. Kim, S. Machida, Isaac Myers, S. Suzuki, Tomohiro Matsuda, Charlie Jui, J. Yang, K. Kitamoto, Inkyu Park, Yoshiki Tsunesada, Daisuke Ikeda, J. Lan, Hideaki Shimodaira, K. Kobayashi, Mayuko Minamino, K. Hayashi, S. R. Stratton, Douglas Bergman, Hiroyuki Sagawa, K. Honda, Toshiyuki Nonaka, Tiffany Wong, T. Fukuda, Masaki Fukushima, Yasunori Kitamura, T. Fujii, Vladim Kuzmin, R. Aida, Hiroshi Yamaoka, S. Yoshida, Fumio Kakimoto, Y. Wada, K. Hibino, D. Oku, Sergey Troitsky, K. Tsutsumi, J. I. Shin, K. Hiyama, K. Yamazaki, Takaaki Ishii, Taka Tomida, Tareq Abu-Zayyad, R. Yamane, T.-A. Shibata, Y. Yamakawa, Gordon Thomson, Elliott Barcikowski, Tom Stroman, Robert Cady, D. C. Rodriguez, Dmitri Ivanov, H. Fujii, G. Vasiloff, Akitoshi Oshima, Jyunsei Chiba, Dongsu Ryu, Masato Takita, Y. Tsuyuguchi, Igor Tkachev, Shunsuke Ozawa, Kiyoshi Tanaka, Hyun-Il Kim, T. Matsuyama, Hongsu Kim, Akimichi Taketa, M. Allen, Eiji Kido, Y. Kobayashi, Yuichiro Tameda, John N. Matthews, H. Tokuno, J. D. Smith, K. Miyata, Bokkyun Shin, Pierre Sokolsky, Y. J. Kwon, Hideyuki Ohoka, Shingo Kawana, K. Ikuta, M. Takeda, Shigehiro Nagataki, Dmitry Gorbunov, William Hanlon, T. Okuda, and O. Kalashev
Subjects: Physics, Surface (mathematics), Nuclear and High Energy Physics, Photon, 010308 nuclear & particles physics, Detector, Flux, Cosmic ray, Astrophysics, 01 natural sciences, law.invention, Telescope, law, 0103 physical sciences, Limit (mathematics), Atomic physics, 010306 general physics, Energy (signal processing)
Abstract: We search for ultra-high energy photons by analyzing geometrical properties of shower fronts of events registered by the Telescope Array surface detector. By making use of an event-by-event statistical method, we derive upper limits on the absolute flux of primary photons with energies above ${10}^{19}$, ${10}^{19.5}$, and ${10}^{20}\text{ }\text{ }\mathrm{eV}$ based on the first three years of data taken.
Published: 2013

146. Combined and alternating paracetamol and ibuprofen therapy for febrile children

Author: Tiffany Wong, Heather Ganshorn, Antonia S Stang, Lisa Hartling, David W. Johnson, Ian Maconochie, and Anna M Thomsen
Subjects: Medicine General & Introductory Medical Sciences, medicine.medical_specialty, Antipyretics, Time Factors, Combination therapy, Fever, MEDLINE, Ibuprofen, law.invention, Body Temperature, Randomized controlled trial, law, Internal medicine, medicine, Humans, Pharmacology (medical), Antipyretic, Adverse effect, Child, Acetaminophen, Randomized Controlled Trials as Topic, business.industry, Significant difference, Combined Modality Therapy, Surgery, Meta-analysis, business, medicine.drug
Abstract: Background Health professionals frequently recommend fever treatment regimens for children that either combine paracetamol and ibuprofen or alternate them. However, there is uncertainty about whether these regimens are better than the use of single agents, and about the adverse effect profile of combination regimens. Objectives To assess the effects and side effects of combining paracetamol and ibuprofen, or alternating them on consecutive treatments, compared with monotherapy for treating fever in children. Search methods In September 2013, we searched Cochrane Infectious Diseases Group Specialized Register; Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; LILACS; and International Pharmaceutical Abstracts (2009-2011). Selection criteria We included randomized controlled trials comparing alternating or combined paracetamol and ibuprofen regimens with monotherapy in children with fever. Data collection and analysis One review author and two assistants independently screened the searches and applied inclusion criteria. Two authors assessed risk of bias and graded the evidence independently. We conducted separate analyses for different comparison groups (combined therapy versus monotherapy, alternating therapy versus monotherapy, combined therapy versus alternating therapy). Main results Six studies, enrolling 915 participants, are included. Compared to giving a single antipyretic alone, giving combined paracetamol and ibuprofen to febrile children can result in a lower mean temperature at one hour after treatment (MD -0.27 °Celsius, 95% CI -0.45 to -0.08, two trials, 163 participants, moderate quality evidence). If no further antipyretics are given, combined treatment probably also results in a lower mean temperature at four hours (MD -0.70 °Celsius, 95% CI -1.05 to -0.35, two trials, 196 participants, moderate quality evidence), and in fewer children remaining or becoming febrile for at least four hours after treatment (RR 0.08, 95% CI 0.02 to 0.42, two trials, 196 participants, moderate quality evidence). Only one trial assessed a measure of child discomfort (fever associated symptoms at 24 hours and 48 hours), but did not find a significant difference in this measure between the treatment regimens (one trial, 156 participants, evidence quality not graded). In practice, caregivers are often advised to initially give a single agent (paracetamol or ibuprofen), and then give a further dose of the alternative if the child's fever fails to resolve or recurs. Giving alternating treatment in this way may result in a lower mean temperature at one hour after the second dose (MD -0.60 °Celsius, 95% CI -0.94 to -0.26, two trials, 78 participants, low quality evidence), and may also result in fewer children remaining or becoming febrile for up to three hours after it is given (RR 0.25, 95% CI 0.11 to 0.55, two trials, 109 participants, low quality evidence). One trial assessed child discomfort (mean pain scores at 24, 48 and 72 hours), finding that these mean scores were lower, with alternating therapy, despite fewer doses of antipyretic being given overall (one trial, 480 participants, low quality evidence) Only one small trial compared alternating therapy with combined therapy. No statistically significant differences were seen in mean temperature, or the number of febrile children at one, four or six hours (one trial, 40 participants, very low quality evidence). There were no serious adverse events in the trials that were directly attributed to the medications used. Authors' conclusions There is some evidence that both alternating and combined antipyretic therapy may be more effective at reducing temperatures than monotherapy alone. However, the evidence for improvements in measures of child discomfort remains inconclusive. There is insufficient evidence to know which of combined or alternating therapy might be more beneficial.Future research needs to measure child discomfort using standardized tools, and assess the safety of combined and alternating antipyretic therapy.
Published: 2013

147. Human primary immunodeficiencies causing defects in innate immunity

Author: Tiffany Wong, Stuart E. Turvey, Joanne Yeung, Anne K. Junker, and Kyla J. Hildebrand
Subjects: Mycobacterium Infections, Phagocytes, Innate immune system, business.industry, Common variable immunodeficiency, Primary Immunodeficiency Diseases, Immunology, Toll-Like Receptors, Isolated congenital asplenia, Immunologic Deficiency Syndromes, medicine.disease, Virology, Immunity, Innate, Common Variable Immunodeficiency, Immunity, Primary immunodeficiency, Immunology and Allergy, Medicine, Humans, Genetic Predisposition to Disease, Encephalitis, Herpes Simplex, business, Encephalitis, Spleen
Abstract: There have been exciting recent advances in identifying new mutations that cause human primary immunodeficiencies which impact innate immune defences. In this review, we will highlight the most important and influential advances published in the last 18 months related to the defects of the innate immune system. We will also provide clinical context to facilitate the incorporation of these discoveries into clinical practice.We will specifically focus on three areas that have seen recent significant advances: defects in Toll-like receptor signalling that enhance susceptibility to viral infection, particularly herpes simplex encephalitis; defects in innate immunity that impact phagocyte function predisposing to mycobacterial infection; and the discovery of genes responsible for isolated congenital asplenia.The field of innate immunodeficiency has benefited greatly from the recent improvements in genome sequencing technology and has advanced dramatically in the last 18 months. For clinicians confronted with patients with suspected innate immunodeficiency, these new discoveries not only increase the likelihood that a patient will receive a specific molecular diagnosis and tailored therapy, but also add significant complexity to the diagnostic workup. Future challenges will include identifying accurate, cost-effective diagnostic approaches to these novel immunodeficiencies, so these impressive advances in our understanding of innate immunity can be translated into improved health outcomes for our affected patients and their families.
Published: 2013

148. TCT-785 The 'Eyeball Test' in Aortic Stenosis: Characterizing Subjective Frailty with Objective Measures

Author: Christopher W. Hawk, Philip Green, Kishore J. Harjai, Jean-Michel Paradis, Mathew R. Williams, Tiffany Wong, Tamim Nazif, Martin B. Leon, Isaac George, Rosa M. Lazarte, Ajay J. Kirtane, and Susheel Kodali
Subjects: Stenosis, medicine.medical_specialty, business.industry, medicine, Physical therapy, medicine.disease, Risk assessment, business, Cardiology and Cardiovascular Medicine, Surgery, Frailty assessment, Test (assessment)
Abstract: Assessment of frailty complements traditional risk assessment in high-risk older adults with aortic stenosis (AS). Subjective frailty assessment is widely used, but its associations with objective markers of frailty are poorly characterized. Frailty was subjectively assessed by an interventional
Published: 2013
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149. Combined and alternating paracetamol and ibuprofen therapy for fever in children

Author: Tiffany Wong, David W Johnson, Heather Ganshorn, Ian K Maconochie, Lisa Hartling, and Antonia S. Stang
Published: 2012

150. The Energy Spectrum of Telescope Array's Middle Drum Detector and the Direct Comparison to the High Resolution Fly's Eye Experiment

Author: Fumiya Shibata, R. Ishimori, Y. J. Kwon, Hideyuki Ohoka, Y. Wada, O. Kalashev, R. W. Springer, Sergey Troitsky, Y. Uchihori, S. Suzuki, Jihee Kim, Tomohiro Matsuda, Hideaki Shimodaira, N. Sakurai, T.-A. Shibata, Douglas Bergman, Gordon Thomson, K. Miyata, Y. Yoneda, W. R. Cho, Tom Stroman, R. Zollinger, Robert Cady, Toru Nakamura, Kenichi Kadota, D. Oku, K. Hiyama, Pierre Sokolsky, N. Inoue, S. I. Lim, Kiyoshi Kuramoto, K. Kobayashi, Y. Kobayashi, K. Kitamoto, Bokkyun Shin, John Belz, Naoaki Hayashida, Y. Tsuyuguchi, M. Takeda, Shigehiro Nagataki, S. Kitamura, Y. Murano, Hiroyuki Sagawa, Ben Stokes, Mayuko Minamino, K. Honda, M. Ohnishi, T. Matsuyama, K. Yamazaki, Tareq Abu-Zayyad, R. Yamane, K. Martens, Takaaki Ishii, T. Shirahama, H. Kawai, S. Y. Roh, Yasunori Kitamura, Masaaki Tanaka, C. C. H. Jui, Hideki Tanaka, D. C. Rodriguez, K. Oki, Yuichiro Tameda, John N. Matthews, Inkyu Park, HangBae Kim, T. Kanbe, T. Fujii, K. Tsutsumi, Dmitry Gorbunov, L. M. Scott, K. Hibino, S. B. Thomas, Robert M. Anderson, S. Yoshida, Y. Hayashi, Isaac Myers, Maxim Pshirkov, Shingo Kawana, Akimichi Taketa, William Hanlon, Akitoshi Oshima, B. G. Cheon, J. Martineau, S. Machida, Shunsuke Ozawa, Y. Kondo, Vladim Kuzmin, Eiji Kido, S. Udo, K. Ikuta, R. Aida, A. L. Sampson, Kiyoshi Tanaka, H. Yoshii, Grigory Rubtsov, K. Hayashi, Yoshiki Tsunesada, S. Kawakami, H. Tokuno, Fumio Kakimoto, J. D. Smith, Daisuke Ikeda, M. Allen, Elliott Barcikowski, Dmitri Ivanov, S. R. Stratton, H. Fujii, Tiffany Wong, Yukio Takahashi, T. Fukuda, Masaki Fukushima, J. I. Shin, E. J. Cho, Michiyuki Chikawa, J. Yang, Zach Zundel, Toshiyuki Nonaka, Hiroshi Yamaoka, G. Vasiloff, Jyunsei Chiba, Dongsu Ryu, T. J. Sonley, S. W. Nam, H. Ukai, Priti Shah, S. Iwamoto, H. K. Kim, Masato Takita, R. Azuma, T. Matsuura, Samuel Blake, Shoichi Ogio, K. Kasahara, Takeshi Okuda, Igor Tkachev, Takayuki Tomida, T. Iguchi, M. Wood, P. Tinyakov, and Y. Yamakawa
Subjects: Physics, Monocular, business.industry, Detector, FOS: Physical sciences, Astronomy and Astrophysics, Drum, Scintillator, law.invention, Telescope, Optics, law, Scintillation counter, Calibration, business, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Energy (signal processing)
Abstract: The Telescope Array's Middle Drum fluorescence detector was instrumented with telescopes refurbished from the High Resolution Fly's Eye's HiRes-1 site. The data observed by Middle Drum in monocular mode was analyzed via the HiRes-1 profile-constrained geometry reconstruction technique and utilized the same calibration techniques enabling a direct comparison of the energy spectra and energy scales between the two experiments. The spectrum measured using the Middle Drum telescopes is based on a three-year exposure collected between December 16, 2007 and December 16, 2010. The calculated difference between the spectrum of the Middle Drum observations and the published spectrum obtained by the data collected by the HiRes-1 site allows the HiRes-1 energy scale to be transferred to Middle Drum. The HiRes energy scale is applied to the entire Telescope Array by making a comparison between Middle Drum monocular events and hybrid events that triggered both Middle Drum and the Telescope Array's scintillator Ground Array., Comment: 27 pages, 21 figures
Published: 2012
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