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104. Search for transient gravitational waves in coincidence with short-duration radio transients during 2007-2013

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Alejandro Garcia, Michael E Zucker, Courtney R. Epstein, Roman Schnabel, S. Mastrogiovanni, J. E. Brau, A. A. van Veggel, Efim A. Khazanov, G. Ballardin, B. D. Lackey, L. Pinard, J. L. Willis, D. J. McManus, Howard Pan, Denis Martynov, R. Robie, Marco Bazzan, Kipp Cannon, M. Steinke, A. Kutynia, F. Clara, D. Meacher, M. Fays, B. M. Levine, J. Flanigan, A. Cumming, Aaron Buikema, C. C. Wipf, E. J. King, M. J. Cowart, V. Dolique, Federico Ferrini, R. S. Ottens, G. Vajente, P. Kumar, Q. Chu, W. Z. Korth, K. Siellez, C. Baune, Laura Cadonati, E. Genin, F. Baldaccini, Evan Ochsner, D. Ugolini, N. Letendre, B. R. Hall, A. J. Weinstein, A. Di Lieto, V. Boschi, G. Mazzolo, M. Landry, S. Ascenzi, M. Lormand, J. Bergman, H. J. Bulten, J. P. Zendri, Michael Kramer, B. Mours, G. McIntyre, P. Thomas, Z. Patrick, V. Malvezzi, David Jones, Erik Katsavounidis, Vladimir B. Braginsky, H. Vahlbruch, T. Chalermsongsak, Alessandro Bertolini, K. Riles, H. Middleton, M. Weinert, F. Fidecaro, G. M. Guidi, M. Barsuglia, A. Grant, N. Mazumder, M. Prijatelj, T. Dal Canton, J. Warner, H. N. Isa, M. J. Hart, C. J. Bell, N. A. Robertson, L. Kleybolte, J. C. Driggers, P. Puppo, A. W. Muir, C. L. Mueller, C. C. Arceneaux, R. Cavalieri, H. Rew, R. Passaquieti, A. Perreca, Marco Cavaglia, S. J. Chamberlin, M. Vasúth, G. Dojcinoski, Francesco Pannarale, H. Qi, R. F. Cardoso, J. K. Blackburn, A. Sawadsky, Timothy MacDonald, Leo Singer, T. Isogai, M. Branchesi, A. K. Srivastava, Robinjeet Singh, E. Chassande-Mottin, J. C. Batch, Jonathan Cripe, Sheila Rowan, G. A. Prodi, R. DeSalvo, K. Mason, Márton Tápai, David Jonathan Hofman, E. C. Ferreira, E. A. Huerta, B. Behnke, R. Birney, Susan M. Scott, I. Khan, Y. Wang, G. M. Harry, D. Rosińska, K. Venkateswara, Aaron Berndsen, Patrice Hello, Laleh Sadeghian, V. P. Mitrofanov, S. T. Countryman, A. W. Heptonstall, Vivien Raymond, Peter R. Saulson, L. Cerboni Baiardi, T. D. Abbott, O. Puncken, A. Ford, V. Necula, Surabhi Sachdev, Christopher J. Moore, Daniele Trifirò, Chad Hanna, K. A. Hodge, Bala R. Iyer, J. M. Gonzalez Castro, Yuri Levin, S. McCormick, O. V. Palashov, Sean T. McWilliams, M. Merzougui, Carl-Johan Haster, C. Aulbert, F. Piergiovanni, Chang-Hwan Lee, G. Cerretani, L. Trozzo, S. Mirshekari, M. C. Araya, Sanjeev Dhurandhar, Jason W. T. Hessels, Albert Lazzarini, Y. Minenkov, E. G. Thomas, A. Basti, P. G. Murray, Todd Adams, R. Goetz, F. Frasconi, Tarun Souradeep, Liam Cunningham, R. M. Martin, Robert Stone, A. Di Virgilio, A. R. Williamson, W. Del Pozzo, P. F. Cohadon, H. Heitmann, Roy Williams, G. Pillant, V. V. Frolov, L. Rolland, W. D. Vousden, Albrecht Rüdiger, J. Oberling, A. Singhal, L. Matone, Fabrizio Barone, Haocun Yu, Fiodor Sorrentino, B. K. Berger, M. Davier, M. J. Yap, Samaya Nissanke, Jens Birch, Z. Frei, T. Penucci, M. Ast, O. E. S. Sauter, F. Mezzani, Fabien Kéfélian, J. H. Hough, M. Mohan, K. G. Arun, T. Huynh-Dinh, J. Luo, K. Haris, Chunglee Kim, Xing-Jiang Zhu, V. Sequino, M. S. Shahriar, S. Huang, P. Bacon, Daniel E. Holz, S. Márka, D. Barta, J. S. Kissel, V. I. Kondratiev, B. J. J. Slagmolen, Joshua Yablon, D. Passuello, N. Man, Fan Zhang, Collin D. Capano, D. J. Vine, J. R. Palamos, T. Z. Summerscales, Stanislav Babak, D. Day, Namjun Kim, J.-D. Fournier, M. H. Wimmer, K. Kokeyama, J. J. Hacker, Philip F. Hopkins, William Yam, L. Wallace, S. Chung, S. Farinon, M. Constancio, Duncan A. Brown, T. Sadecki, A. Królak, R. Frey, Kenneth A. Strain, Jimin George, M. Sieniawska, A. Moggi, Kevin M. Ryan, H. J. Jang, Gregory Ashton, Fabio Marchesoni, Maria Ilaria Del Principe, B. Patricelli, F. Garufi, C. M. Reed, M. Korobko, G. D. Meadors, Margaret Millhouse, S. Grunewald, M. Agathos, S. G. Gaonkar, D. Bersanetti, S. R. Morriss, Riccardo Bassiri, Magnus Manske, E. Maros, Douglas R. Cook, A. Viceré, Yi Chen, M. E. Normandin, G. Bogaert, Haixing Miao, K. Haughian, J. Eichholz, B. C. Stephens, Marc Favata, V. M. Kaspi, Roger Jones, V. J. Roma, Michele Zanolin, Michael Pürrer, Serena Vinciguerra, F. Nocera, D. J. White, I. Fiori, D. J. Hosken, C. Zhao, E. Coccia, C. Graef, B. A. Weaver, J. G. Rollins, Kyungmin Kim, D. D. Brown, B. O'Reilly, T. J. Massinger, T. Vo, O. J. Piccinni, S. B. Coughlin, S. L. Danilishin, M. Shaltev, O. Bock, L. Di Fiore, James G. Bartlett, K. L. Dooley, G. Mendell, T. Di Girolamo, L.-W. Wei, N. van Bakel, Lisa Barsotti, R. J. G. Jonker, I. Kowalska, S. Kaufer, Eric Oelker, M. Boer, J. B. Kanner, Rainer Weiss, S. Penn, D. Schuette, A. Giazotto, R. Pedurand, Benno Willke, Joonghan Kim, A. Grado, Fredrick A. Jenet, P. Shawhan, Alberto Vecchio, L. Prokhorov, I. Ferrante, C. Cahillane, Will M. Farr, Subhabrata Mitra, R. W. P. Drever, E. A. Quintero, J. Hennig, G. L. Mansell, Jessica Steinlechner, A. Neunzert, Duncan R. Lorimer, Nam-Gyu Kim, S. A. Usman, G. D. Hammond, D. H. Shoemaker, M. Kasprzack, P. Couvares, P. Charlton, Kejia Lee, P. Brockill, G. Vedovato, D. B. Kozak, Tyson Littenberg, T. B. Edo, Gavin Davies, A. Lenon, B. L. Pearlstone, M. Ducrot, Archisman Ghosh, X. F. Wang, Rebecca Fisher, Maura McLaughlin, H. Fehrmann, W. W. Johnson, G. P. Newton, M. Fyffe, Michael L. Gorodetsky, T. Westphal, Ryan Lynch, M. Heurs, S. S. Premachandra, A. Masserot, V. Dattilo, Tejinder Kaur, Edwin J. Son, K. Kawabe, D. Huet, S. H. Huttner, F. Cleva, Marie-Anne Bizouard, S. Walsh, A. Sheperd, Maximiliano Isi, Zifan Zhou, M. Montani, Alessandra Buonanno, R. Metzdorff, Nancy Aggarwal, Zahoor Ali Khan, V. Fafone, Andrew Melatos, Kendall Ackley, R. K. Nayak, D. Mendoza-Gandara, J-Y. Vinet, B. Shapiro, Reed Essick, R. Everett, Jan Harms, D. Talukder, C. V. Torres, S. M. Aston, C. Vorvick, I. W. Harry, Satyanarayan Ray Pitambar Mohapatra, Viswanath Bavigadda, A. Sevigny, P. B. Graff, I. A. Bilenko, J. L. Wright, Alessandra Corsi, David J. Ottaway, A. Paoli, A. R. Wade, R. S. Lynch, G. Kuehn, C. M. Mow-Lowry, Sergey P. Vyatchanin, A. Idrisy, M. Yvert, Lionel Martellini, Kazuhiro Agatsuma, F. Magaña-Sandoval, R. M. Magee, Peter Fritschel, Gabriela Gonzalez, Benjamin William Allen, P. J. Sutton, P. Bojtos, David Blair, Karsten Danzmann, J. Betzwieser, M. Gosselin, Alex B. Nielsen, J. H. Romie, G. Serna, Stefan Hild, Y. Ma, P. Chawla, S. Kandhasamy, B. Sorazu, T. Etzel, Hua Wang, S. E. Hollitt, Vicky Kalogera, G. Lunsford, D. B. Kelley, C. Palomba, J.-M. Isac, Heinz-Bernd Eggenstein, Zhihui Du, V. Predoi, I. W. Martin, L. Rei, M. Masso-Reid, Mark Hannam, I. Dave, Adam A. Libson, M. Fletcher, B. Hughey, Evan Goetz, Michael W. Coughlin, A. L. Stuver, J. E. Lord, M. Mageswaran, C. C. Yancey, A. Ain, B. F. Whiting, J. Casanueva Diaz, Lei Zhang, P. Schale, E. Cuoco, A. Gupta, M. Tonelli, Larry R. Price, John Miller, Leopoldo Milano, Slawomir Gras, C. Bond, Nergis Mavalvala, Sascha Husa, A. Gennai, H. P. Daveloza, C. Van Den Broeck, Arielle N. Walker, Jordan Camp, P. Wessels, T. T. Nguyen, C. S. Unnikrishnan, Lloyd Paul Aiello, R. Douglas, F. J. Raab, David E. McClelland, Scott M. Ransom, B. C. Pant, N. Indik, Andrea Chincarini, T. Prestegard, S. S. Eikenberry, M. S. Kehl, A. Post, Yanxi Zhang, M. Bejger, Hartmut Grote, F. Marion, E. J. Daw, J. Schmidt, Kevin Stovall, C. Krueger, Rosa Poggiani, V. Germain, V. Frey, Jong H. Chow, Paolo Addesso, K. D. Giardina, G. Losurdo, L. Conti, Ingrid H. Stairs, M. Vardaro, A. Pasqualetti, A. Mytidis, A. Pele, P. Raffai, R. Chakraborty, D. M. Macleod, S. E. Gossan, G. Greco, L. E. Wade, J. S. Lange, B. L. Swinkels, Neil J. Cornish, Evan Keane, G. Bergmann, J. Hanks, N. A. Strauss, Timothy A Welborn, V. Tiwari, K. Gill, Walter Winkler, Jiayi Qin, A. Singer, M. C. Díaz, Samuel Deléglise, L. P. Dartez, C. Pankow, P. M. Meyers, Hyun Lee, M. D. Rohr, J. Calderón Bustillo, Jerome Degallaix, Y. Setyawati, C. Casentini, Sebastian Khan, F. Carbognani, E. O. Lebigot, T. Denker, Christopher P. L. Berry, A. D. Silva, H. J. Pletsch, Enrico Calloni, G. Traylor, Thomas Corbitt, L. Salconi, C. A. Costa, L. R. Cominsky, R. Gustafson, M. P. Thirugnanasambandam, N. Straniero, G. Wu, F. Robinet, S. Meshkov, Seog Oh, W. G. Anderson, G. Cella, Giacomo Ciani, B. P. Abbott, E. K. Gustafson, Meng Wang, D.B. DeBra, A. Bisht, M. Leonardi, S. E. Zuraw, Sourav Ghosh, Imre Bartos, V. Quetschke, Bangalore Suryanarayana Sathyaprakash, Martin M. Fejer, J. R. Smith, R. Bork, L. van der Schaaf, S. A. Pai, Cody Messick, Yann Bouffanais, A. Bohe, A. C. Green, Fausto Acernese, Fumiko Kawazoe, D. Moraru, A. S. Markosyan, Madeline Wade, P. Leaci, A. Colla, Harald Lück, D. Verkindt, J. N. Marx, Vuk Mandic, Gianpietro Cagnoli, László Á. Gergely, Tania Regimbau, M. M. Hanke, Barry C. Barish, Christian D. Ott, K. Nedkova, S. Tiwari, S. B. Anderson, M. Cho, Paul J. Groot, M. Zevin, A. Staley, L. Zangrando, Sung-Po Chao, John A. Clark, S. Jawahar, T. Theeg, Ben Farr, V. Re, E. A. Houston, X. Guo, Matthew Evans, S. Vass, A. Glaefke, C. Tomlinson, J. D. Lough, R. Coyne, Mi Zhang, C. Gray, G. H. Ogin, Soma Mukherjee, S. C. McGuire, J. F. Read, M. K. Gupta, J. G. Martinez, John Veitch, S. Di Pace, J. C. Barayoga, D. Nolting, M. Neri, J. A. Giaime, S. Raja, S. E. Strigin, Y. M. Kim, R. De Rosa, Ruslan Vaulin, David B. Tanner, F. Jiménez-Forteza, H. Radkins, N. S. Darman, N. Arnaud, Maggie Tse, Christophe Collette, Ho-Gyu Lee, K. A. Thorne, C. Messenger, Fabrice Matichard, R. Inta, Aviral Singh, P. J. King, W. Kells, S. Klimenko, M. MacInnis, M. Mantovani, H. R. Paris, L. Kuo, H. Yamamoto, E. Capocasa, Thibaut Jacqmin, C. I. Torrie, A. Mata, P. Rapagnani, D. R. Ingram, A. Bozzi, B. A. Boom, S. D'Antonio, A. Allocca, M. Brinkmann, F. Vetrano, J. Zweizig, D. C. Coyne, E. L. Merilh, K. Izumi, M. C. Tringali, I. Nardecchia, Anne M. Archibald, Sebastian Steinlechner, Andreas Freise, Vincenzo Pierro, Paul D. Lasky, S. G. Crowder, J. van Leeuwen, I. Maksimovic, A. Rocchi, D. V. Voss, R. L. Ward, G. Hemming, Matthew Pitkin, D. Stiles, N. Gehrels, N. A. Gordon, Xavier Siemens, P. J. Veitch, Andrew Lundgren, M. Factourovich, S. Koley, S. Leake, A. Schönbeck, T. P. Downes, R. L. Savage, A. S. Bell, D. Pascucci, Mallory S. E. Roberts, J. R. Sanders, J. Prasad, W. Katzman, F. Y. Khalili, M. Saleem, Carlos Cepeda, Robert J. McCarthy, H. Fair, M. Pichot, Andrea Taracchini, J. V. van Heijningen, David Coward, Sheon Chua, R. Bonnand, N. Leroy, M. Granata, Marek Szczepanczyk, Minchuan Zhou, G. Wang, C. Bradaschia, P. Oppermann, Linqing Wen, Ik Siong Heng, K. N. Mukund, Steven Bloemen, Jonathan R. Gair, M. Pedraza, H. A. G. Gabbard, M. Chan, Ettore Majorana, Christie A. McPhee, W. Engels, S. M. Koehlenbeck, Eric Thrane, Maria Alessandra Papa, F. Cavalier, A. Zadro.zny, C. Michel, G. Valdes, S. E. Dwyer, David Keitel, G. Islas, G. Debreczeni, Chia-Liang Cheng, Antoine Heidmann, Gleb Romanov, Nicholas Smith, Qi Fang, Rui Miguel Faisca Rodrigues Pereira, D. Töyrä, N. A. Lockerbie, H. Overmier, T. Hardwick, D. Steinmeyer, P. Ehrens, F. Travasso, Blake Moore, Sarah Caudill, R. Quitzow-James, R. Day, F. Ohme, V. B. Adya, William Parker, Z. Shao, M. Razzano, A. Nitz, S. Banaszak, D. Simakov, E. Schreiber, G. Kang, A. Pal-Singh, M. Was, A. L. Miller, B. Sandeen, M. C. Edwards, C. Bogan, J. Hinojosa, Thomas Dent, Vladimir Dergachev, S. Karki, D. Sellers, James Whelan, M. Bitossi, K. Wette, F. Martelli, Karan Jani, Suvadeep Bose, Gijs Nelemans, Graham Woan, P. Astone, Larne Pekowsky, Robert L. Byer, V. Kondrashov, I. Di Palma, Stuart Reid, A. Samajdar, P. Ajith, M. Punturo, H. Vocca, J. Meidam, John J. Oh, Timothy Evans, Eugeniy E. Mikhailov, R. Gouaty, Z. Márka, E. D. Hall, Jolien D. E. Creighton, S. Caride, Arunava Mukherjee, R. Mittleman, Nelson Christensen, Riccardo Sturani, M. T. Hartman, V. Kringel, Rory Smith, C. Adams, R. M. Blair, D. Sigg, S. W. Ballmer, K. Holt, D. M. Shoemaker, G. Gemme, V. Sandberg, Bernard F. Schutz, D. S. Rabeling, Li Ju, H. Wittel, Daniel A. Shaddock, M. Phelps, T. T. Fricke, C. V. Kalaghatgi, J. Hanson, D. Hoak, Michelle E. Walker, G. Moreno, D. Sentenac, M. Di Giovanni, K. E. Gushwa, Matthew Heintze, Rocco Romano, J. S. Key, John D. Scott, D. L. Kinzel, R. A. Mercer, Tomasz Bulik, M. Turconi, Patrick Brady, J. S. Areeda, D. Fiorucci, Richard J. Oram, François Bondu, Guido Mueller, Joseph D. Romano, J. Ming, A. Conte, T. A. Callister, N. Kijbunchoo, Michael Thomas, Sebastien Biscans, David Murphy, A. Effler, A. L. Lombardi, M. Drago, Guenakh Mitselmakher, J. R. Leong, G. Stratta, Jesper Munch, M. van Beuzekom, C. C. Buchanan, M. Haney, P. Popolizio, Koji Arai, H. S. Cho, P. Fulda, Kasem Mossavi, Jade Powell, V. Mangano, Achamveedu Gopakumar, M. De Laurentis, E. J. Sanchez, S. E. Barclay, David H. Reitze, Yi-Ming Hu, Tjonnie G. F. Li, Eric Howell, F. Ricci, S. Leavey, L. K. Nuttall, J. Boyles, M. R. Abernathy, G. Billingsley, A. M. Sergeev, D. Buskulic, J. Logue, B. Lantz, C. Affeldt, R. Taylor, R. T. DeRosa, T. P. Bodiya, R. M. S. Schofield, M. Oliver, Benjamin J. Owen, J. F. J. van den Brand, M. Tacca, Martin Hendry, E. 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Lazzaro, Patricia Schmidt, V. Brisson, A. M. Sintes, P. Aufmuth, Chandra Kant Mishra, R. Bhandare, Piotr Jaranowski, California Institute of Technology, Louisiana State University, Fisciano, Complesso Universitario di Monte S. 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Paris 11 (UP11), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des matériaux avancés (LMA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Science and Engineering Research Board, Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada, Alfred P. Sloan Foundation, Carnegie Trust for the Universities of Scotland, Science and Technology Facilities Council, Ontario Ministry of Economic Development and Innovation, Ministerio de Economía y Competitividad, Scottish Funding Council, Seventh Framework Programme, Industry Canada, Council of Scientific and Industrial Research, Australian Research Council, Royal Society, Narodowe Centrum Nauki, National Aeronautics and Space Administration, 617199, European Research Council, Centre National de la Recherche Scientifique, Max-Planck-Gesellschaft, Department of Science and Technology, Ministry of Science and Technology, Research Corporation for Science Advancement, National Science Foundation, Leverhulme Trust, David and Lucile Packard Foundation, Országos Tudományos Kutatási Alapprogramok, State of Niedersachsen, International Science Linkages, Conselleria d’Economia i Competitivitat and Conselleria d’Educaci, Universitats of the Govern de les Illes Balears, Lyon Institute of Origins, Brazilian Ministry of Science, Technology, and Innovation, Ministry of Human Resource Development, Scottish Universities Physics Alliance, Stichting voor Fundamenteel Onderzoek der Materie, Istituto Nazionale di Fisica Nucleare, National Research Foundation of Korea, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, LIGO, VIRGO, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux ( ARTEMIS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Institut de Physique de Rennes ( IPR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des matériaux avancés ( LMA ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), The LIGO Scientific Collaboration, The Virgo Collaboration, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), (Astro)-Particles Physics, Abbott, B. P., Abbott, R., Abbott, T. D., Abernathy, M. R., Acernese, F., Ackley, K., Adams, C., Adams, T., Addesso, P., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Allen, B., Allocca, A., Altin, P. A., Anderson, S. B., Anderson, W. G., Arai, K., Araya, M. C., Arceneaux, C. C., Areeda, J. S., Arnaud, N., Arun, K. G., Ascenzi, S., Ashton, G., Ast, M., Aston, S. M., Astone, P., Aufmuth, P., Aulbert, C., Babak, S., Bacon, P., Bader, M. K. M., Baker, P. T., Baldaccini, F., Ballardin, G., Ballmer, S. W., Barayoga, J. C., Barclay, S. E., Barish, B. C., Barker, D., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Batch, J. C., Baune, C., Bavigadda, V., Bazzan, M., Behnke, B., Bejger, M., Bell, A. S., Bell, C. J., Berger, B. K., Bergman, J., Bergmann, G., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhagwat, S., Bhandare, R., Bilenko, I. A., Billingsley, G., Birch, J., Birney, R., Biscans, S., Bisht, A., Bitossi, M., Biwer, C., Bizouard, M. A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bloemen, S., Bock, O., Bodiya, T. P., Boer, M., Bogaert, G., Bogan, C., Bohe, A., Bojtos, P., Bond, C., Bondu, F., Bonnand, R., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Braginsky, V. B., Branchesi, M., Brau, J. E., Briant, T., Brillet, A., Brinkmann, M., Brisson, V., Brockill, P., Brooks, A. F., Brown, D. A., Brown, D. D., Brown, N. M., Buchanan, C. C., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Buy, C., Byer, R. L., Cadonati, L., Cagnoli, G., Cahillane, C., Calderón Bustillo, J., Callister, T., Calloni, Enrico, Camp, J. B., Cannon, K. C., Cao, J., Capano, C. D., Capocasa, E., Carbognani, F., Caride, S., Casanueva Diaz, J., Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C. B., Cerboni Baiardi, L., Cerretani, G., Cesarini, E., Chakraborty, R., Chalermsongsak, T., Chamberlin, S. J., Chan, M., Chao, S., Charlton, P., Chassande Mottin, E., Chen, H. Y., Chen, Y., Cheng, C., Chincarini, A., Chiummo, A., Cho, H. S., Cho, M., Chow, J. H., Christensen, N., Chu, Q., Chua, S., Chung, S., Ciani, G., Clara, F., Clark, J. A., Cleva, F., Coccia, E., Cohadon, P. F., Colla, A., Collette, C. G., Cominsky, L., Constancio, M., Conte, A., Conti, L., Cook, D., Corbitt, T. R., Cornish, N., Corsi, A., Cortese, S., Costa, C. A., Coughlin, M. W., Coughlin, S. B., Coulon, J. P., Countryman, S. T., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Craig, K., Creighton, J. D. E., Cripe, J., Crowder, S. G., Cumming, A., Cunningham, L., Cuoco, E., Dal Canton, T., Danilishin, S. L., D'Antonio, S., Danzmann, K., Darman, N. S., Dattilo, V., Dave, I., Daveloza, H. P., Davier, M., Davies, G. S., Daw, E. J., Day, R., Debra, D., Debreczeni, G., Degallaix, J., DE LAURENTIS, Martina, Deléglise, S., Del Pozzo, W., Denker, T., Dent, T., Dergachev, V., DE ROSA, Rosario, Derosa, R. T., Desalvo, R., Dhurandhar, S., Díaz, M. C., Di Fiore, L., Di Giovanni, M., DI GIROLAMO, Tristano, Di Lieto, A., Di Pace, S., Di Palma, I., Di Virgilio, A., Dojcinoski, G., Dolique, V., Donovan, F., Dooley, K. L., Doravari, S., Douglas, R., Downes, T. P., Drago, M., Drever, R. W. P., Driggers, J. C., Du, Z., Ducrot, M., Dwyer, S. E., Edo, T. B., Edwards, M. C., Effler, A., Eggenstein, H. B., Ehrens, P., Eichholz, J., Eikenberry, S. S., Engels, W., Essick, R. C., Etzel, T., Evans, M., Evans, T. M., Everett, R., Factourovich, M., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Fang, Q., Farinon, S., Farr, B., Farr, W. M., Favata, M., Fays, M., Fehrmann, H., Fejer, M. M., Ferrante, I., Ferreira, E. C., Ferrini, F., Fidecaro, F., Fiori, I., Fiorucci, D., Fisher, R. P., Flaminio, R., Fletcher, M., Fournier, J. D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fricke, T. T., Fritschel, P., Frolov, V. V., Fulda, P., Fyffe, M., Gabbard, H. A. G., Gair, J. R., Gammaitoni, L., Gaonkar, S. G., Garufi, Fabio, Gaur, G., Gehrels, N., Gemme, G., Genin, E., Gennai, A., George, J., Gergely, L., Germain, V., Ghosh, Archisman, Ghosh, S., Giaime, J. A., Giardina, K. D., Giazotto, A., Gill, K., Glaefke, A., Goetz, E., Goetz, R., Gondan, L., González, G., Gonzalez Castro, J. M., Gopakumar, A., Gordon, N. A., Gorodetsky, M. L., Gossan, S. E., Gosselin, M., Gouaty, R., Grado, A., Graef, C., Graff, P. B., Granata, M., Grant, A., Gras, S., Gray, C., Greco, G., Green, A. C., Groot, P., Grote, H., Grunewald, S., Guidi, G. M., Guo, X., Gupta, A., Gupta, M. K., Gushwa, K. E., Gustafson, E. K., Gustafson, R., Hacker, J. J., Hall, B. R., Hall, E. D., Hammond, G., Haney, M., Hanke, M. M., Hanks, J., Hanna, C., Hannam, M. D., Hanson, J., Hardwick, T., Harms, J., Harry, G. M., Harry, I. W., Hart, M. J., Hartman, M. T., Haster, C. J., Haughian, K., Heidmann, A., Heintze, M. C., Heitmann, H., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Hennig, J., Heptonstall, A. W., Heurs, M., Hild, S., Hoak, D., Hodge, K. A., Hofman, D., Hollitt, S. E., Holt, K., Holz, D. E., Hopkins, P., Hosken, D. J., Hough, J., Houston, E. A., Howell, E. J., Hu, Y. M., Huang, S., Huerta, E. A., Huet, D., Hughey, B., Husa, S., Huttner, S. H., Huynh Dinh, T., Idrisy, A., Indik, N., Ingram, D. R., Inta, R., Isa, H. N., Isac, J. M., Isi, M., Islas, G., Isogai, T., Iyer, B. R., Izumi, K., Jacqmin, T., Jang, H., Jani, K., Jaranowski, P., Jawahar, S., Jiménez Forteza, F., Johnson, W. W., Jones, D. I., Jones, R., Jonker, R. J. G., Ju, L., Haris, K., Kalaghatgi, C. V., Kalogera, V., Kandhasamy, S., Kang, G., Kanner, J. B., Karki, S., Kasprzack, M., Katsavounidis, E., Katzman, W., Kaufer, S., Kaur, T., Kawabe, K., Kawazoe, F., Kéfélian, F., Kehl, M. S., Keitel, D., Kelley, D. B., Kells, W., Kennedy, R., Key, J. S., Khalaidovski, A., Khalili, F. Y., Khan, I., Khan, S., Khan, Z., Khazanov, E. A., Kijbunchoo, N., Kim, Chunglee, Kim, J., Kim, K., Kim, Nam Gyu, Kim, Namjun, Kim, Y. M., King, E. J., King, P. J., Kinzel, D. L., Kissel, J. S., Kleybolte, L., Klimenko, S., Koehlenbeck, S. M., Kokeyama, K., Koley, S., Kondrashov, V., Kontos, A., Korobko, M., Korth, W. Z., Kowalska, I., Kozak, D. B., Kringel, V., Królak, A., Krueger, C., Kuehn, G., Kumar, P., Kuo, L., Kutynia, A., Lackey, B. D., Landry, M., Lange, J., Lantz, B., Lasky, P. D., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lebigot, E. O., Lee, C. H., Lee, H. K., Lee, H. M., Lee, K., Lenon, A., Leonardi, M., Leong, J. R., Leroy, N., Letendre, N., Levin, Y., Levine, B. M., Li, T. G. F., Libson, A., Littenberg, T. B., Lockerbie, N. A., Logue, J., Lombardi, A. L., Lord, J. E., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lück, H., Lundgren, A. P., Luo, J., Lynch, R., Ma, Y., Macdonald, T., Machenschalk, B., Macinnis, M., Macleod, D. M., Magaña Sandoval, F., Magee, R. M., Mageswaran, M., Majorana, E., Maksimovic, I., Malvezzi, V., Man, N., Mandic, V., Mangano, V., Mansell, G. L., Manske, M., Mantovani, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markosyan, A. S., Maros, E., Martelli, F., Martellini, L., Martin, I. W., Martin, R. M., Martynov, D. V., Marx, J. N., Mason, K., Masserot, A., Massinger, T. J., Masso Reid, M., Mastrogiovanni, S., Matichard, F., Matone, L., Mavalvala, N., Mazumder, N., Mazzolo, G., Mccarthy, R., Mcclelland, D. E., Mccormick, S., Mcguire, S. C., Mcintyre, G., Mciver, J., Mcmanus, D. J., Mcwilliams, S. T., Meacher, D., Meadors, G. D., Meidam, J., Melatos, A., Mendell, G., Mendoza Gandara, D., Mercer, R. A., Merilh, E. L., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. M., Mezzani, F., Miao, H., Michel, C., Middleton, H., Mikhailov, E. E., Milano, Leopoldo, Miller, A. L., Miller, J., Millhouse, M., Minenkov, Y., Ming, J., Mirshekari, S., Mishra, C., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Moggi, A., Mohan, M., Mohapatra, S. R. P., Montani, M., Moore, B. C., Moore, C. J., Moraru, D., Moreno, G., Morriss, S. R., Mossavi, K., Mours, B., Mow Lowry, C. M., Mueller, C. L., Mueller, G., Muir, A. W., Mukherjee, Arunava, Mukherjee, D., Mukherjee, S., Mukund, K. N., Mullavey, A., Munch, J., Murphy, D. J., Murray, P. G., Mytidis, A., Nardecchia, I., Naticchioni, L., Nayak, R. K., Necula, V., Nedkova, K., Nelemans, G., Neri, M., Neunzert, A., Newton, G., Nguyen, T. T., Nielsen, A. B., Nissanke, S., Nitz, A., Nocera, F., Nolting, D., Normandin, M. E. N., Nuttall, L. K., Oberling, J., Ochsner, E., O'Dell, J., Oelker, E., Ogin, G. H., Oh, J. J., Oh, S. H., Ohme, F., Oliver, M., Oppermann, P., Oram, Richard J., O'Reilly, B., O'Shaughnessy, R., Ott, C. D., Ottaway, D. J., Ottens, R. S., Overmier, H., Owen, B. J., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pal Singh, A., Pan, H., Pankow, C., Pannarale, F., Pant, B. C., Paoletti, F., Paoli, A., Papa, M. A., Paris, H. R., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patricelli, B., Patrick, Z., Pearlstone, B. L., Pedraza, M., Pedurand, R., Pekowsky, L., Pele, A., Penn, S., Pereira, R., Perreca, A., Phelps, M., Piccinni, O. J., Pichot, M., Piergiovanni, F., Pierro, V., Pillant, G., Pinard, L., Pinto, I. M., Pitkin, M., Pletsch, H. J., Poggiani, R., Popolizio, P., Post, A., Powell, J., Prasad, J., Predoi, V., Premachandra, S. S., Prestegard, T., Price, L. R., Prijatelj, M., Principe, M., Privitera, S., Prodi, G. A., Prokhorov, L., Puncken, O., Punturo, M., Puppo, P., Pürrer, M., Qi, H., Qin, J., Quetschke, V., Quintero, E. A., Quitzow James, R., Raab, F. J., Rabeling, D. S., Radkins, H., Raffai, P., Raja, S., Rakhmanov, M., Rapagnani, P., Raymond, V., Razzano, M., Re, V., Read, J., Reed, C. M., Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Rew, H., Ricci, F., Riles, K., Robertson, N. A., Robie, R., Robinet, F., Rocchi, A., Rolland, L., Rollins, J. G., Roma, V. J., Romano, J. D., Romano, R., Romanov, G., Romie, J. H., Rosińska, D., Rowan, S., Rüdiger, A., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadeghian, L., Salconi, L., Saleem, M., Salemi, F., Samajdar, A., Sammut, L., Sanchez, E. J., Sandberg, V., Sandeen, B., Sanders, J. R., Sassolas, B., Sathyaprakash, B. S., Saulson, P. R., Sauter, O. E. S., Savage, R. L., Sawadsky, A., Schale, P., Schilling, R., Schmidt, J., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schönbeck, A., Schreiber, E., Schuette, D., Schutz, B. F., Scott, J., Scott, S. M., Sellers, D., Sentenac, D., Sequino, V., Sergeev, A., Serna, G., Setyawati, Y., Sevigny, A., Shaddock, D. A., Shahriar, M. S., Shaltev, M., Shao, Z., Shapiro, B., Shawhan, P., Sheperd, A., Shoemaker, D. H., Shoemaker, D. M., Siellez, K., Siemens, X., Sieniawska, M., Sigg, D., Silva, A. D., Simakov, D., Singer, A., Singer, L. P., Singh, A., Singh, R., Singhal, A., Sintes, A. M., Slagmolen, B. J. J., Smith, J. R., Smith, N. D., Smith, R. J. E., Son, E. J., Sorazu, B., Sorrentino, F., Souradeep, T., Srivastava, A. K., Staley, A., Steinke, M., Steinlechner, J., Steinlechner, S., Steinmeyer, D., Stephens, B. C., Stiles, D., Stone, R., Strain, K. A., Straniero, N., Stratta, G., Strauss, N. A., Strigin, S., Sturani, R., Stuver, A. L., Summerscales, T. Z., Sun, L., Sutton, P. J., Swinkels, B. L., Szczepańczyk, M. J., Tacca, M., Talukder, D., Tanner, D. B., Tápai, M., Tarabrin, S. P., Taracchini, A., Taylor, R., Theeg, T., Thirugnanasambandam, M. P., Thomas, E. G., Thomas, M., Thomas, P., Thorne, K. A., Thrane, E., Tiwari, S., Tiwari, V., Tokmakov, K. V., Tomlinson, C., Tonelli, M., Torres, C. V., Torrie, C. I., Töyrä, D., Travasso, F., Traylor, G., Trifirò, D., Tringali, M. 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L., Willke, B., Wimmer, M. H., Winkler, W., Wipf, C. C., Wittel, H., Woan, G., Worden, J., Wright, J. L., Wu, G., Yablon, J., Yam, W., Yamamoto, H., Yancey, C. C., Yap, M. J., Yu, H., Yvert, M., Zadrożny, A., Zangrando, L., Zanolin, M., Zendri, J. P., Zevin, M., Zhang, F., Zhang, L., Zhang, M., Zhang, Y., Zhao, C., Zhou, M., Zhou, Z., Zhu, X. J., Zucker, M. E., Zuraw, S. E., Zweizig, J., Archibald, A. M., Banaszak, S., Berndsen, A., Boyles, J., Cardoso, R. F., Chawla, P., Cherry, A., Dartez, L. P., Day, D., Epstein, C. R., Ford, A. J., Flanigan, J., Garcia, A., Hessels, J. W. T., Hinojosa, J., Jenet, F. A., Karako Argaman, C., Kaspi, V. M., Keane, E. F., Kondratiev, V. I., Kramer, M., Leake, S., Lorimer, D., Lunsford, G., Lynch, R. S., Martinez, J. G., Mata, A., Mclaughlin, M. A., Mcphee, C. A., Penucci, T., Ransom, S., Roberts, M. S. E., Rohr, M. D. W., Stairs, I. H., Stovall, K., Van Leeuwen, J., Walker, A. N., Wells, B. 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K. .a., Hollitt, S. .e., Holz, D. .e., Hosken, D. .j., Houston, E. .a., Howell, E. .j., Hu, Y. .m., Huerta, E. .a., Huttner, S. .h., Ingram, D. .r., Isa, H. .n., Iyer, B. .r., Johnson, W. .w., Jones, D. .i., Jonker, R. .j. .g., Kalaghatgi, C. .v., Kanner, J. .b., Kehl, M. .s., Kelley, D. .b., Key, J. .s., Khalili, F. .y., Khazanov, E. .a., King, E. .j., King, P. .j., Kinzel, D. .l., Kissel, J. .s., Koehlenbeck, S. .m., Korth, W. .z., Kozak, D. .b., Lackey, B. .d., Lasky, P. .d., Lebigot, E. .o., Lee, C. .h., Lee, H. .k., Lee, H. .m., Leong, J. .r., Levine, B. .m., Li, T. .g. .f., Littenberg, T. .b., Lockerbie, N. .a., Lombardi, A. .l., Lord, J. .e., Lough, J. .d., Lundgren, A. .p., Macleod, D. .m., Magee, R. .m., Mansell, G. .l., Markosyan, A. .s., MARTELLI, FILIPPO, Martin, I. .w., Martin, R. .m., Martynov, D. .v., Marx, J. .n., Massinger, T. .j., Mcclelland, D. .e., Mcguire, S. .c., Mcmanus, D. .j., Mcwilliams, S. .t., Meadors, G. .d., Mercer, R. .a., Merilh, E. .l., Meyers, P. .m., 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Schutz, B. .f., Scott, S. .m., Shaddock, D. .a., Shahriar, M. .s., Shoemaker, D. .h., Shoemaker, D. .m., Silva, A. .d., Singer, L. .p., Sintes, A. .m., Slagmolen, B. .j. .j., Smith, J. .r., Smith, N. .d., Smith, R. .j. .e., Son, E. .j., Srivastava, A. .k., Stephens, B. .c., Strain, K. .a., STRATTA, MARIA GIULIANA, Strauss, N. .a., Stuver, A. .l., Summerscales, T. .z., Sutton, P. .j., Swinkels, B. .l., Szczepańczyk, M. .j., Tanner, D. .b., Tarabrin, S. .p., Thirugnanasambandam, M. .p., Thomas, E. .g., Thorne, K. .a., Tokmakov, K. .v., Torres, C. .v., Torrie, C. .i., Tringali, M. .c., Unnikrishnan, C. .s., Urban, A. .l., Usman, S. .a., van Bakel, N., van Beuzekom, M., van den Brand, J. .f. .j., Vander Hyde, D. .c., van der Schaaf, L., van Heijningen, J. .v., van Veggel, A. .a., Veitch, P. .j., VETRANO, FLAVIO, VICERE', ANDREA, Vine, D. .j., Voss, D. .v., Vousden, W. .d., Vyatchanin, S. .p., Wade, A. .r., Wade, L. .e., Ward, R. .l., Weinstein, A. .j., Whelan, J. .t., Whitcomb, S. .e., White, D. .j., Whiting, B. .f., Williams, R. .d., Williamson, A. .r., Willis, J. .l., Wimmer, M. .h., Wipf, C. .c., Wright, J. .l., Yancey, C. .c., Yap, M. .j., Zhu, X. .j., Zucker, M. .e., Zuraw, S. .e., Archibald, A. .m., Cardoso, R. .f., Dartez, L. .p., Epstein, C. .r., Ford, A. .j., Hessels, J. .w. .t., Jenet, F. .a., Kaspi, V. .m., Keane, E. .f., Kondratiev, V. .i., Lynch, R. .s., Martinez, J. .g., Mclaughlin, M. .a., Mcphee, C. .a., Roberts, M. .s. .e., Rohr, M. .d. .w., Stairs, I. .h., van Leeuwen, J., Walker, A. .n., Wells, B. .l., CALTECH, Louisiana State Univ, Univ Salerno, Ist Nazl Fis Nucl, Univ Florida, LIGO Livingston Observ, Univ Savoie Mont Blanc, Univ Sannio Benevento, Max Planck Inst Gravitat Phys, NIKHEF H, MIT, Inst Nacl Pesquisas Espaciais, Inter Univ Ctr Astron & Astrophys, Tata Inst Fundamental Res, Univ Wisconsin, Leibniz Univ Hannover, Univ Pisa, Australian Natl Univ, Univ Mississippi, Calif State Univ Fullerton, Univ Paris Saclay, Chennai Math Inst, Univ Roma Tor Vergata, Univ Southampton, Univ Hamburg, Universidade de São Paulo (USP), Montana State Univ, Univ Perugia, EGO, Syracuse Univ, Univ Glasgow, LIGO Hanford Observ, Columbia Univ, Stanford Univ, Univ Padua, CAMK PAN, Univ Birmingham, Univ Genoa, Lomonosov Moscow State Univ, Univ West Scotland, Univ Western Australia, Radboud Univ Nijmegen, Univ Cote Azur, MTA Eotvos Univ, Univ Rennes 1, Washington State Univ, Univ Urbino Carlo Bo, Univ Oregon, Univ Paris 06, Warsaw Univ, Vrije Univ Amsterdam, Univ Maryland, Georgia Inst Technol, CNRS IN2P3, Univ Lyon 1, Univ Illes Balears, Univ Naples Federico II, NASA, Univ Toronto, Tsinghua Univ, Univ Michigan, Natl Tsing Hua Univ, Charles Sturt Univ, Univ Chicago, Korea Inst Sci & Technol Informat, Carleton Coll, Univ Roma La Sapienza, Univ Brussels, Sonoma State Univ, Texas Tech Univ, Cardiff Univ, Univ Minnesota, Univ Melbourne, Univ Texas Rio Grande Valley, Univ Sheffield, Univ Trento, Montclair State Univ, Penn State Univ, Natl Astron Observ Japan, Univ Edinburgh, Indian Inst Technol, Inst Plasma Res, Univ Szeged, Embry Riddle Aeronaut Univ, Amer Univ, Univ Massachusetts, Univ Adelaide, W Virginia Univ, Univ Bialystok, Univ Strathclyde, IISER TVM, Northwestern Univ, Inst Appl Phys, Pusan Natl Univ, Hanyang Univ, IM PAN, Rochester Inst Technol, Monash Univ, Seoul Natl Univ, Univ Alabama, Univ Camerino, Southern Univ, A&M Coll, Coll William & Mary, Universidade Estadual Paulista (Unesp), Univ Cambridge, IISER Kolkata, Rutherford Appleton Lab, Whitman Coll, Natl Inst Math Sci, Univ Lyon, Hobart & William Smith Coll, Univ Zielona Gora, Andrews Univ, Univ Siena, Trinity Univ, Univ Washington, Kenyon Coll, Abilene Christian Univ, ASTRON, Univ British Columbia, Western Kentucky Univ, McGill Univ, Ohio State Univ, Univ Amsterdam, SKA Org, Lebedev Phys Inst, Max Planck Inst Radioastron, Univ Manchester, Natl Radio Astron Observ, Univ Virginia, Eureka Sci Inc, Univ New Mexico, Colorado State Univ, and High Energy Astrophys. & Astropart. Phys (API, FNWI)

Subjects
Radio Transients, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Nuclear and High Energy Physics, Astronomy, Astrophysics::High Energy Astrophysical Phenomena, detection, FOS: Physical sciences, Gravitational Wave, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Coincidence, GAMMA-RAY BURST, ENERGY, Pulsar, Settore FIS/05 - Astronomia e Astrofisica, Gravitational Waves, Radio Transients, 0103 physical sciences, Binary star, coincidence, 010303 astronomy & astrophysics, QC, QB, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Gravitational Waves, PLASMA, 010308 nuclear & particles physics, Gravitational wave, ORIGIN, Settore FIS/01 - Fisica Sperimentale, Green Bank Telescope, Astrophysics::Instrumentation and Methods for Astrophysics, [ PHYS.ASTR.HE ] Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], PULSARS, LIGO, PULSES, Neutron star, Physics and Astronomy, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, GW, Gamma-ray burst, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Copyright © 2016 American Physical Society and reproduced in accordance with the publisher copyright policy, We present an archival search for transient gravitational-wave bursts in coincidence with 27 single-pulse triggers from Green Bank Telescope pulsar surveys, using the LIGO, Virgo, and GEO interferometer network. We also discuss a check for gravitational-wave signals in coincidence with Parkes fast radio bursts using similar methods. Data analyzed in these searches were collected between 2007 and 2013. Possible sources of emission of both short-duration radio signals and transient gravitational-wave emission include starquakes on neutron stars, binary coalescence of neutron stars, and cosmic string cusps. While no evidence for gravitational-wave emission in coincidence with these radio transients was found, the current analysis serves as a prototype for similar future searches using more sensitive second-generation interferometers.

Published
2016
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106. The Sick, Control, One Stone, Fat, Food (SCOFF) is a Valid Eating Disorder Questionnaire to Use With Transgender Youth.

Author

Linsenmeyer W, Stiles D, Garwood S, Giedinghagen A, Lewis C, and Strand G

Subjects
Humans, Adolescent, Female, Male, Surveys and Questionnaires, Reproducibility of Results, Young Adult, Psychometrics methods, Factor Analysis, Statistical, Transgender Persons psychology, Transgender Persons statistics & numerical data, Feeding and Eating Disorders diagnosis, Feeding and Eating Disorders psychology
Abstract

Transgender youth experience elevated rates of eating disorders, yet few screening measures have been validated with transgender patients. The purpose of this study was to provide initial evidence for the internal consistency and convergent validity of the Sick, Control, One Stone, Fat, Food (SCOFF) in a sample of transgender youth. Two hundred eight participants completed the SCOFF as part of a routine screening protocol. Exploratory factor analysis and confirmatory factor analysis were used to establish the factor structure of the SCOFF in this sample. Relationships between the SCOFF, Adolescent Binge Eating Disorder (ADO-BED), Nine-Item Avoidant/Restrictive Intake Disorder (NIAS), Patient Health Questionnaire 9 (PHQ-9), Generalized Anxiety Disorder 7 (GAD-7), and demographic characteristics were explored. The SCOFF was significantly related to all convergent validity variables, with moderate correlations with other eating disorder scales (ADO-BED and NIAS). The SCOFF is a valid measure to screen for eating disorders among transgender youth and young adults., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2024
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108. Validation of the adolescent binge eating disorder measure (ADO-BED) among transgender youth and young adults.

Author

Linsenmeyer W, Stiles D, Garwood S, Giedinghagen A, Lewis C, and Strand G

Abstract

Background: Transgender youth and young adults are at increased risk for eating disorders, including binge eating disorder, yet few measures have been validated for screening purposes with the transgender population., Methods: The purpose of this study was to provide initial evidence for the internal consistency and convergent validity of the Adolescent Binge Eating Disorder questionnaire (ADO-BED) in a sample of transgender youth and young adults. 208 participants completed the ADO-BED as part of a routine nutrition screening protocol at a gender center. Exploratory factor analysis and confirmatory factor analysis was used to establish the factor structure of the ADO-BED. Relationships between the ADO-BED, Sick, Control, One Stone, Fat, Food (SCOFF), Nine Item Avoidant/restrictive Intake Disorder (NIAS), Patient Health Questionnaire 9 (PHQ-9), Generalized Anxiety Disorder 7 (GAD-7), and demographic characteristics were explored., Results: Analyses revealed a one-factor structure of the ADO-BED with good fit to the data in the present sample. The ADO-BED was shown to be significantly related to all convergent validity variables, except the NIAS., Conclusions: The ADO-BED is a valid measure to screen for BED among transgender youth and young adults. Healthcare professionals can screen all transgender patients for BED, regardless of body size, in order to effectively identify and manage binge eating concerns., (© 2023. The Author(s).)

Published
2023
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109. A meta-analysis of exercise intervention and the effect on Parkinson's Disease symptoms.

Author

Omar Ahmad S, Longhurst J, Stiles D, Downard L, and Martin S

Subjects
Humans, Exercise Therapy methods, Exercise, Parkinson Disease, Neurodegenerative Diseases, Cognitive Dysfunction
Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease that is distinguished by tremors at rest, bradykinesia, hypokinesia, and postural instability, resulting in a progressive decline in performance of everyday activities. The non-motor symptoms that occur can include pain, depression, cognitive dysfunction, sleep issues, and anxiety (among others). Functionality is tremendously impaired by physical as well as non-motor symptoms. Recent treatment has begun to incorporate non-conventional interventions that are more functional and tailored to the patients with PD. The purpose of this meta-analysis was to determine the effectiveness of exercise interventions at alleviating PD symptoms, as measured by the Unified Parkinson's Disease Rating Scale (UPDRS). Additionally, this review qualitatively explored whether endurance-based or non-endurance based exercise interventions were more beneficial at alleviating PD symptoms. Two reviewers screened the title and abstract records (n = 668) found in the initial search. Subsequently the reviewers completed full-text screening of the remaining articles for inclusion.. Following this, a total of 25 articles were considered to be eligible and included in the review and data was extracted for meta-analysis. The interventions lasted from 4 to 26 weeks. Results indicated a positive overall effect of therapeutic exercise on patients with PD, where the overall d-index was 0.155. Qualitatively no difference was observed between aerobic and non-aerobic forms of exercise., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Published
2023
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110. Advancing Inclusion of Transgender Identities in Health Professional Education Programs: The Interprofessional Transgender Health Education Day.

Author

Linsenmeyer W, Stiles D, Drallmeier T, Heiden-Rootes K, Rahman R, Buxbaum E, Gombos B, Harris N, Johnson S, Lantz C, Otte A, Rosen W, and Lillioja S

Subjects
Humans, Students, Health Personnel education, Attitude of Health Personnel, Interprofessional Education, Health Education, Interprofessional Relations, Transgender Persons
Abstract

Purpose: The purpose of this study was to explore the impact of an Interprofessional Transgender Health Education Day (ITHED) on student knowledge and attitudes towards the transgender population., Methods: This mixed-methods study involved a pre-test and post-test survey administered to students (n=84 pre-test and n=66 post-test) in four health professional education programs (medicine, family therapy, speech, language, and hearing sciences, nutrition and dietetics.) surrounding participation in the ITHED. Differences in total and subscale scores of the Transgender Knowledge, Attitudes and Beliefs (T-KAB) before and after participation in the ITHED scale were analyzed using independent samples t-tests; qualitative responses were analyzed using a thematic, inductive process., Results: Independent samples t-tests revealed no significant differences in pre- and post-ITHED total T- KAB scores, the three subscales, or for those who reported previous training, clinical experience, and regular contact with transgender individuals. Qualitative themes included: enthusiasm for learning about transgender health; need for healthcare providers to provide excellent care for transgender patients; and power of learning directly from the transgender community., Conclusions: Though participation in the ITHED did not result in significant changes in T-KAB scores, participants demonstrated high baseline T-KAB scores and expressed strong enthusiasm for learning about transgender health. Positioning transgender voices at the forefront of the education can foster a powerful student learning experience and honor ethical guidelines.

Published
2023

111. FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2 -/- Mouse Model of Primary Sclerosing Cholangitis.

Author

O'Brien A, Zhou T, White T, Medford A, Chen L, Kyritsi K, Wu N, Childs J, Stiles D, Ceci L, Chakraborty S, Ekser B, Baiocchi L, Carpino G, Gaudio E, Wu C, Kennedy L, Francis H, Alpini G, and Glaser S

Subjects
ATP Binding Cassette Transporter, Subfamily B metabolism, Animals, Disease Models, Animal, Fibroblast Growth Factor 1 genetics, Fibrosis, Humans, Inflammation, Liver Cirrhosis drug therapy, Male, Mice, Mice, Knockout, ATP-Binding Cassette Sub-Family B Member 4, Cholangitis, Sclerosing drug therapy, MicroRNAs genetics
Abstract

Fibroblast growth factor 1 (FGF1) belongs to a family of growth factors involved in cellular growth and division. MicroRNA 16 (miR-16) is a regulator of gene expression, which is dysregulated during liver injury and insult. However, the role of FGF1 in the progression of biliary proliferation, senescence, fibrosis, inflammation, angiogenesis, and its potential interaction with miR-16, are unknown. In vivo studies were performed in male bile duct-ligated (BDL, 12-week-old) mice, multidrug resistance 2 knockout (Mdr2 -/-) mice (10-week-old), and their corresponding controls, treated with recombinant human FGF1 (rhFGF1), fibroblast growth factor receptor (FGFR) antagonist (AZD4547), or anti-FGF1 monoclonal antibody (mAb). In vitro, the human cholangiocyte cell line (H69) and human hepatic stellate cells (HSCs) were used to determine the expression of proliferation, fibrosis, angiogenesis, and inflammatory genes following rhFGF1 treatment. PSC patient and control livers were used to evaluate FGF1 and miR-16 expression. Intrahepatic bile duct mass (IBDM), along with hepatic fibrosis and inflammation, increased in BDL mice treated with rhFGF1, with a corresponding decrease in miR-16, while treatment with AZD4547 or anti-FGF1 mAb decreased hepatic fibrosis, IBDM, and inflammation in BDL and Mdr2 -/- mice. In vitro, H69 and HSCs treated with rhFGF1 had increased expression of proliferation, fibrosis, and inflammatory markers. PSC samples also showed increased FGF1 and FGFRs with corresponding decreases in miR-16 compared with healthy controls. Conclusion: Our study demonstrates that suppression of FGF1 and miR-16 signaling decreases the presence of hepatic fibrosis, biliary proliferation, inflammation, senescence, and angiogenesis. Targeting the FGF1 and miR-16 axis may provide therapeutic options in treating cholangiopathies such as PSC., (© 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.)

Published
2022
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112. Obesity as a Possible Risk Factor for Pediatric Sensorineural Hearing Loss.

Author

Bluher A, Kawai K, Wang A, Stiles D, and Licameli G

Subjects
Adolescent, Audiometry, Body Mass Index, Child, Child, Preschool, Databases, Factual, Female, Humans, Logistic Models, Male, Odds Ratio, Pediatric Obesity complications, Retrospective Studies, Risk Factors, Thinness complications, Hearing, Hearing Loss, Sensorineural etiology, Pediatric Obesity physiopathology, Thinness physiopathology
Abstract

Objectives/hypothesis: Childhood hearing loss impacts linguistic, academic, social, and psychologic development, and may have lasting implications for future workforce performance. Current evidence for obesity as a pediatric sensorineural hearing loss (SNHL) risk factor is intriguing but equivocal. We hypothesized that obesity is associated with a higher risk of SNHL. We additionally examined whether underweight is associated with a higher risk of SNHL., Study Design: Retrospective database review., Methods: A single-institution audiologic database from 2015 to 2020 was queried for audiograms with type-A tympanograms from children aged 5 to 18 years old. Comorbidities known to be associated with hearing loss were excluded. We then examined both for sub-clinical (≥15 dB) high- or low-frequency hearing loss, and for clinical (≥21 dB) hearing loss, with the aim of examining the association between obesity and SNHL. Multivariable logistic regression was performed to adjust for age, gender, diabetes mellitus, attention deficit hyperactivity disorder, and autism., Results: A total of 3,142 children were included. Obesity was not associated with risk of SNHL (adjusted OR 0.82; 95% CI: 0.60, 1.12). Underweight children had a higher risk of SNHL than normal weight children (adjusted OR 1.78; 95% CI: 1.08, 2.95). Autism was significantly associated with increased risk of sub-clinical SNHL only (adjusted OR 2.00; 95% CI 1.34, 2.98)., Conclusions: No association was found between obesity and pediatric SNHL. Underweight children may represent a higher-risk population for SNHL. There appears to be an increasing risk of SNHL as children approach adolescence. Further study of systemic risk factors for SNHL is indicated., Level of Evidence: 3 Laryngoscope, 131:1416-1419, 2021., (© 2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA).)

Published
2021
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113. Perspective on the Development of a Large-Scale Clinical Data Repository for Pediatric Hearing Research.

Author

Pennington JW, Ruth B, Miller JM, Peterson J, Xu B, Masino AJ, Krantz I, Manganella J, Gomes T, Stiles D, Kenna M, Hood LJ, Germiller J, and Crenshaw EB 3rd

Subjects
Child, Cohort Studies, Databases, Factual, Hearing, Humans, Audiology
Abstract

The use of "big data" for pediatric hearing research requires new approaches to both data collection and research methods. The widespread deployment of electronic health record systems creates new opportunities and corresponding challenges in the secondary use of large volumes of audiological and medical data. Opportunities include cost-effective hypothesis generation, rapid cohort expansion for rare conditions, and observational studies based on sample sizes in the thousands to tens of thousands. Challenges include finding and forming appropriately skilled teams, access to data, data quality assessment, and engagement with a research community new to big data. The authors share their experience and perspective on the work required to build and validate a pediatric hearing research database that integrates clinical data for over 185,000 patients from the electronic health record systems of three major academic medical centers.

Published
2020
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114. Reducing the primate pet trade: Actions for primatologists.

Author

Norconk MA, Atsalis S, Tully G, Santillán AM, Waters S, Knott CD, Ross SR, Shanee S, and Stiles D

Subjects
Animals, Animals, Wild, Commerce, Conservation of Natural Resources legislation & jurisprudence, Crime, Animals, Exotic, Pets economics, Primates
Abstract

This commentary emerged from a panel presentation at the International Primatological Society Congress in Nairobi, Kenya, 2018. The goal was to provide regional updates on the status of primate removal from habitat countries, especially for the pet trade, and develop guidelines that could help primatologists address this critical problem. The trade in live primates includes those used as pets, in entertainment, and as subjects of biomedical experimentation, but here we focus on those primates destined for the pet trade. Such transactions are a hugely lucrative business, impacting hundreds of thousands of individuals annually and affecting the survival of wild populations. Being intimately familiar with primate social behavior, life history and biology, primatologists, whether they work with captive or wild primates, are in a unique position to understand the nature of the trade and attempt to counter its effects. In addition to updating the status of the primate pet trade, we provide recommendations that may help primatologists formulate a plan to deal, locally and regionally, with illegal trafficking in live primates. General guidelines include increasing awareness of local customs, policies and laws; developing collaborative research opportunities for local people; engaging in training/informational opportunities; and instructing on how to take action when encountering illegally-trafficked primates., (© 2019 The Authors. American Journal of Primatology published by Wiley Periodicals, Inc.)

Published
2020
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115. A phase 3 study of tezacaftor in combination with ivacaftor in children aged 6 through 11 years with cystic fibrosis.

Author

Walker S, Flume P, McNamara J, Solomon M, Chilvers M, Chmiel J, Harris RS, Haseltine E, Stiles D, Li C, Ahluwalia N, Zhou H, Owen CA, and Sawicki G

Subjects
Biological Availability, Child, Child, Preschool, Chloride Channel Agonists administration & dosage, Chloride Channel Agonists adverse effects, Chloride Channel Agonists pharmacokinetics, Dose-Response Relationship, Drug, Drug Monitoring methods, Drug Therapy, Combination methods, Female, Humans, Male, Mutation, Treatment Outcome, Aminophenols administration & dosage, Aminophenols adverse effects, Aminophenols pharmacokinetics, Benzodioxoles administration & dosage, Benzodioxoles adverse effects, Benzodioxoles pharmacokinetics, Cystic Fibrosis diagnosis, Cystic Fibrosis drug therapy, Cystic Fibrosis genetics, Cystic Fibrosis Transmembrane Conductance Regulator genetics, Indoles administration & dosage, Indoles adverse effects, Indoles pharmacokinetics, Quinolones administration & dosage, Quinolones adverse effects, Quinolones pharmacokinetics, Respiratory Function Tests methods, Sweat chemistry, Sweat drug effects
Abstract

Background: Tezacaftor/ivacaftor is a new treatment option in many regions for patients aged ≥12 years who are homozygous (F/F) or heterozygous for the F508del-CFTR mutation and a residual function (F/RF) mutation. This Phase 3, 2-part, open-label study evaluated the pharmacokinetics (PK), safety, tolerability, and efficacy of tezacaftor/ivacaftor in children aged 6 through 11 years with these mutations., Methods: Part A informed weight-based tezacaftor/ivacaftor dosages for part B. The primary objective of part B was to evaluate the safety and tolerability of tezacaftor/ivacaftor through 24 weeks; the secondary objective was to evaluate efficacy based on changes from baseline in percentage predicted forced expiratory volume in 1 s (ppFEV 1 ), growth parameters, sweat chloride, and the Cystic Fibrosis Questionnaire-Revised (CFQ-R) respiratory domain score., Results: After PK analysis in part A, 70 children received ≥1 dose of tezacaftor/ivacaftor in part B; 67 children completed treatment. Exposures in children aged 6 through 11 years were within the target range for those observed in patients aged ≥12 years. The safety profile of tezacaftor/ivacaftor was generally similar to prior studies in patients aged ≥12 years. One child discontinued treatment for a serious adverse event of constipation. Tezacaftor/ivacaftor treatment improved sweat chloride levels and CFQ-R respiratory domain scores, mean ppFEV 1 remained stable in the normal range, and growth parameters remained stable over 24 weeks., Conclusions: Tezacaftor/ivacaftor was generally safe and well tolerated, and improved CFTR function in children aged 6 through 11 years with CF with F/F and F/RF genotypes, supporting tezacaftor/ivacaftor use in this age group. NCT02953314., (Copyright © 2019. Published by Elsevier B.V.)

Published
2019
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116. Cases in Precision Medicine: Concerns About Privacy and Discrimination After Genomic Sequencing.

Author

Stiles D and Appelbaum PS

Subjects
Genetic Predisposition to Disease, Humans, United States, Genetic Counseling legislation & jurisprudence, Genetic Privacy legislation & jurisprudence, Genetic Testing legislation & jurisprudence, Genomics legislation & jurisprudence, Precision Medicine, Prejudice legislation & jurisprudence
Abstract

Patients and research participants have indicated that privacy of their genetic test results is an important concern, particularly with respect to insurance coverage. Internists and other physicians whose patients ask about legal protections for information generated by genome sequencing for clinical purposes can provide both reassurance and caution. Protections for medical information in general, as well as laws in some states that provide additional safeguards for genetic data, should reassure patients that this information will remain private. Patients themselves will need to weigh the risks versus the benefits of generating genomic data in deciding whether to undergo exome sequencing.

Published
2019
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117. Cases in Precision Medicine: When Patients Present With Direct-to-Consumer Genetic Test Results.

Author

Artin MG, Stiles D, Kiryluk K, and Chung WK

Subjects
Adult, Female, Genetic Carrier Screening, Genetic Counseling, Genetic Privacy, Humans, Male, Physician-Patient Relations, Precision Medicine, Preconception Care, Direct-To-Consumer Screening and Testing, Genetic Testing
Abstract

A couple is planning to start a family, and they decide to order a 23andMe test after reading about the company's carrier screening test and the new BRCA1/BRCA2 test. They bring the results to their internist for advice on how to proceed. Given the rise in public interest in human genetics and precision medicine, direct-to-consumer genetic testing is becoming increasingly popular, and clinicians should expect patients to present the results of these tests more frequently. This article uses a case scenario to provide information about what the results of these tests mean, and what they do not mean.

Published
2019
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119. Safety, pharmacokinetics, and pharmacodynamics of lumacaftor and ivacaftor combination therapy in children aged 2-5 years with cystic fibrosis homozygous for F508del-CFTR: an open-label phase 3 study.

Author

McNamara JJ, McColley SA, Marigowda G, Liu F, Tian S, Owen CA, Stiles D, Li C, Waltz D, Wang LT, and Sawicki GS

Subjects
Age Factors, Aminophenols administration & dosage, Aminophenols adverse effects, Aminophenols pharmacokinetics, Aminopyridines administration & dosage, Aminopyridines adverse effects, Aminopyridines pharmacokinetics, Benzodioxoles administration & dosage, Benzodioxoles adverse effects, Benzodioxoles pharmacokinetics, Child, Preschool, Chloride Channel Agonists administration & dosage, Chloride Channel Agonists adverse effects, Chloride Channel Agonists pharmacokinetics, Cystic Fibrosis genetics, Drug Therapy, Combination, Female, Homozygote, Humans, Male, Quinolones administration & dosage, Quinolones adverse effects, Quinolones pharmacokinetics, Aminophenols therapeutic use, Aminopyridines therapeutic use, Benzodioxoles therapeutic use, Chloride Channel Agonists therapeutic use, Cystic Fibrosis drug therapy, Cystic Fibrosis Transmembrane Conductance Regulator genetics, Quinolones therapeutic use
Abstract

Background: The efficacy, safety, and tolerability of lumacaftor and ivacaftor are established in patients aged 6 years and older with cystic fibrosis, homozygous for the F508del-CFTR mutation. We assessed the safety, pharmacokinetics, pharmacodynamics, and efficacy of lumacaftor and ivacaftor in children aged 2-5 years., Methods: In this multicentre, phase 3, open-label, two-part study, we enrolled children aged 2-5 years, weighing at least 8 kg at enrolment, with a confirmed diagnosis of cystic fibrosis who were homozygous for the F508del-CFTR mutation. Children received lumacaftor 100 mg and ivacaftor 125 mg (bodyweight <14 kg) or lumacaftor 150 mg and ivacaftor 188 mg (bodyweight ≥14 kg) orally every 12 h for 15 days in part A (to assess pharmacokinetics and safety) and for 24 weeks in part B (to assess safety, pharmacokinetics, pharmacodynamics, and efficacy). Children could participate in part A, part B, or both. Children were enrolled into part A at five sites in the USA and into part B at 20 sites in North America (USA, 17 sites; Canada, three sites). The primary endpoints of the study were the pharmacokinetics (part A) and safety (part B) of lumacaftor and ivacaftor; all analyses were done in children who received at least one dose of lumacaftor and ivacaftor. Secondary endpoints in part A were safety and pharmacokinetics of the metabolites of lumacaftor and ivacaftor, and in part B included pharmacokinetics in children who received at least one dose of lumacaftor and ivacaftor and absolute changes from baseline in sweat chloride concentration, growth parameters, and markers of pancreatic function. This study is registered with ClinicalTrials.gov, number NCT02797132., Findings: The study was done from May 13, 2016, to Sept 8, 2017. 12 children enrolled in part A, 11 of whom completed the 15-day treatment period and enrolled in part B. 60 children enrolled in part B, 56 of whom completed the 24-week treatment period. Safety and pharmacokinetics were consistent with the well characterised safety profile of lumacaftor and ivacaftor. In part B, most children (59 [98%] of 60 children) had one or more treatment-emergent adverse events; most events were mild to moderate in severity. The most common adverse events were cough (38 [63%] of 60), vomiting (17 [28%]), pyrexia (17 [28%]), and rhinorrhoea (15 [25%]). Serious adverse events occurred in four children: infective pulmonary exacerbation of cystic fibrosis (n=2), gastroenteritis viral (n=1), and constipation (n=1). Three (5%) of 60 children discontinued treatment because of elevated serum aminotransferase concentrations. Mean sweat chloride concentrations decreased by 31·7 mmol/L, biomarkers of pancreatic function improved (fecal elastase-1 concentrations increased and serum immunoreactive trypsinogen concentrations decreased), and growth parameters increased at week 24., Interpretation: Lumacaftor and ivacaftor were generally safe and well tolerated in children aged 2-5 years with cystic fibrosis for 24 weeks. Efficacy findings also suggest that early intervention with lumacaftor and ivacaftor has the potential to modify the course of disease., Funding: Vertex Pharmaceuticals Incorporated., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
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120. Reach and messages of the world's largest ivory burn.

Author

Braczkowski A, Holden MH, O'Bryan C, Choi CY, Gan X, Beesley N, Gao Y, Allan J, Tyrrell P, Stiles D, Brehony P, Meney R, Brink H, Takashina N, Lin MC, Lin HY, Rust N, Salmo SG 3rd, Watson JEM, Kahumbu P, Maron M, Possingham HP, and Biggs D

Subjects
Animals, Conservation of Natural Resources, Crime, Kenya, Commerce, Elephants
Abstract

Recent increases in ivory poaching have depressed African elephant populations. Successful enforcement has led to ivory stockpiling. Stockpile destruction is becoming increasingly popular, and most destruction has occurred in the last 5 years. Ivory destruction is intended to send a strong message against ivory consumption, both in promoting a taboo on ivory use and catalyzing policy change. However, there has been no effort to establish the distribution and extent of media reporting on ivory destruction events globally. We analyzed media coverage of the largest ivory destruction event in history (Kenya, 30 April 2016) across 11 nation states connected to ivory trade. We used an online-media crawling tool to search online media outlets and subjected 5 of the largest print newspapers (by circulation) in 5 nations of interest to content analysis. Most online news on the ivory burn came from the United States (81% of 1944 articles), whereas most of the print news articles came from Kenya (61% of 157 articles). Eighty-six to 97% of all online articles reported the burn as a positive conservation action, whereas 4-50% discussed ivory burning as having a negative impact on elephant conservation. Most articles discussed law enforcement and trade bans as effective for elephant conservation. There was more relative search interest globally in the 2016 Kenyan ivory burn than any other burn in 5 years. Ours is the first attempt to track the reach of media coverage relative to an ivory burn and provides a case study in tracking the effects of a conservation-marketing event., (© 2018 Society for Conservation Biology.)

Published
2018
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121. Why words are hard for adults with developmental language impairments.

Author

McGregor KK, Licandro U, Arenas R, Eden N, Stiles D, Bean A, and Walker E

Subjects
Adolescent, Adult, Association Learning physiology, Humans, Language Tests, Mental Recall physiology, Sleep physiology, Young Adult, Language Development Disorders physiopathology, Memory physiology, Semantics, Verbal Learning physiology, Vocabulary
Abstract

Purpose: To determine whether word learning problems associated with developmental language impairment (LI) reflect deficits in encoding or subsequent remembering of forms and meanings., Method: Sixty-nine 18- to 25-year-olds with LI or without (the normal development [ND] group) took tests to measure learning of 16 word forms and meanings immediately after training (encoding) and 12 hr, 24 hr, and 1 week later (remembering). Half of the participants trained in the morning, and half trained in the evening., Results: At immediate posttest, participants with LI performed more poorly on form and meaning than those with ND. Poor performance was more likely among those with more severe LI. The LI-ND gap for word form recall widened over 1 week. In contrast, the LI and ND groups demonstrated no difference in remembering word meanings over the week. In both groups, participants who trained in the evening, and therefore slept shortly after training, demonstrated greater gains in meaning recall than those who trained in the morning., Conclusions: Some adults with LI have encoding deficits that limit the addition of word forms and meanings to the lexicon. Similarities and differences in patterns of remembering in the LI and ND groups motivate the hypothesis that consolidation of declarative memory is a strength for adults with LI.

Published
2013
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122. Children with ASD can use gaze in support of word recognition and learning.

Author

McGregor KK, Rost G, Arenas R, Farris-Trimble A, and Stiles D

Subjects
Adolescent, Child, Female, Humans, Language Tests, Male, Models, Statistical, Reaction Time, Vocabulary, Attention, Child Development Disorders, Pervasive psychology, Child Development Disorders, Pervasive therapy, Cues, Fixation, Ocular, Pattern Recognition, Visual, Recognition, Psychology, Speech Perception, Verbal Learning
Abstract

Background: Many children with autism spectrum disorders (ASD) struggle to understand familiar words and learn unfamiliar words. We explored the extent to which these problems reflect deficient use of probabilistic gaze in the extra-linguistic context., Method: Thirty children with ASD and 43 with typical development (TD) participated in a spoken word recognition and mapping task. They viewed photographs of a woman behind three objects and simultaneously heard a word. For word recognition, the objects and words were familiar and the woman gazed ahead (neutral), toward the named object (facilitative), or toward an un-named object (contradictory). For word mapping, the objects and words were unfamiliar and only the neutral and facilitative conditions were employed. The children clicked on the named object, registering accuracy and reaction time., Results: Speed of word recognition did not differ between groups but varied with gaze such that responses were fastest in the facilitative condition and slowest in the contradictory condition. Only the ASD group responded slower to low frequency than high-frequency words. Accuracy of word mapping did not differ between groups, but accuracy varied with gaze with higher performance in the facilitative than neutral condition. Both groups scored above single-trial chance levels in the neutral condition by tracking cross-situational information. Only in the ASD group did mapping vary with receptive vocabulary., Conclusions: Under laboratory conditions, children with ASD can monitor gaze and judge its reliability as a cue to word meaning as well as typical peers. The use of cross-situational statistics to support word learning may be problematic for those who have weak language abilities., (© 2013 The Authors. Journal of Child Psychology and Psychiatry © 2013 Association for Child and Adolescent Mental Health.)

Published
2013
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124. High-throughput retina-array for screening 93 genes involved in inherited retinal dystrophy.

Author

Song J, Smaoui N, Ayyagari R, Stiles D, Benhamed S, MacDonald IM, Daiger SP, Tumminia SJ, Hejtmancik F, and Wang X

Subjects
Exons genetics, Genetic Testing, Humans, Mutation, Polymerase Chain Reaction, Eye Proteins genetics, Gene Expression Profiling, Oligonucleotide Array Sequence Analysis methods, Retina metabolism, Retinal Dystrophies genetics
Abstract

Purpose: Retinal dystrophy (RD) is a broad group of hereditary disorders with heterogeneous genotypes and phenotypes. Current available genetic testing for these diseases is complicated, time consuming, and expensive. This study was conducted to develop and apply a microarray-based, high-throughput resequencing system to detect sequence alterations in genes related to inherited RD., Methods: A customized 300-kb resequencing chip, Retina-Array, was developed to detect sequence alterations of 267,550 bases of both sense and antisense sequence in 1470 exons spanning 93 genes involved in inherited RD. Retina-Array was evaluated in 19 patient samples with inherited RD provided by the eyeGENE repository and four Centre d'Etudes du Polymorphisme Humaine reference samples through a high-throughput experimental approach that included an automated PCR assay setup and quantification, efficient post-quantification data processing, optimized pooling and fragmentation, and standardized chip processing., Results: The performance of the chips demonstrated that the average base pair call rate and accuracy were 93.56% and 99.86%, respectively. In total, 304 candidate variations were identified using a series of customized screening filters. Among 174 selected variations, 123 (70.7%) were further confirmed by dideoxy sequencing. Analysis of patient samples using Retina-Array resulted in the identification of 10 known mutations and 12 novel variations with high probability of deleterious effects., Conclusions: This study suggests that Retina-Array might be a valuable tool for the detection of disease-causing mutations and disease severity modifiers in a single experiment. Retinal-Array may provide a powerful and feasible approach through which to study genetic heterogeneity in retinal diseases.

Published
2011
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125. Using a natural abilities battery for academic and career guidance: a ten-year study.

Author

Brown CC, Harvey SB, and Stiles D

Subjects
Georgia, Humans, Aptitude Tests, Career Choice, Education, Veterinary standards, Vocational Guidance
Abstract

Over a period of 10 years, first-year students from 11 consecutive veterinary classes conducted a self-assessment using a natural abilities survey. The present study analyzes the data compiled from students' self-assessment results. As a group, veterinary students are exceptional problem solvers, either through inductive or deductive reasoning, and have strong spatial relations capacities. Veterinary students have a range of learning styles with design memory being the primary vehicle for information delivery and tonal memory being the least frequently used style overall. Information gained on each student's natural abilities can be used to guide effective career decision making and enhance prospects for long-term career satisfaction.

Published
2011
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126. Consequences of legal ivory trade.

Author

Walker JF and Stiles D

Subjects
Africa, Animals, Crime, Endangered Species, Population Dynamics, Commerce legislation & jurisprudence, Elephants, International Cooperation
Published
2010
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127. Microarray studies on the genes responsive to the addition of spermidine or spermine to a Saccharomyces cerevisiae spermidine synthase mutant.

Author

Chattopadhyay MK, Chen W, Poy G, Cam M, Stiles D, and Tabor H

Subjects
Down-Regulation, Genes, Fungal, Oligonucleotide Array Sequence Analysis, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae Proteins genetics, Up-Regulation, Gene Deletion, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae enzymology, Saccharomyces cerevisiae physiology, Spermidine metabolism, Spermidine Synthase genetics, Spermine metabolism
Abstract

The naturally occurring polyamines putrescine, spermidine or spermine are ubiquitous in all cells. Although polyamines have prominent regulatory roles in cell division and growth, precise molecular and cellular functions are not well-established in vivo. In this work we have performed microarray experiments with a spermidine synthase, spermine oxidase mutant (Deltaspe3 Deltafms1) strain to investigate the responsiveness of yeast genes to supplementation with spermidine or spermine. Expression analysis identified genes responsive to the addition of either excess spermidine (10(-5) M) or spermine (10(-5) M) compared to a control culture containing 10(-8) M spermidine. 247 genes were upregulated > two-fold and 11 genes were upregulated >10-fold after spermidine addition. Functional categorization of the genes showed induction of transport-related genes and genes involved in methionine, arginine, lysine, NAD and biotin biosynthesis. 268 genes were downregulated more than two-fold, and six genes were downregulated > eight-fold after spermidine addition. A majority of the downregulated genes are involved in nucleic acid metabolism and various stress responses. In contrast, only a few genes (18) were significantly responsive to spermine. Thus, results from global gene expression profiling demonstrate a more major role for spermidine in modulating gene expression in yeast than spermine.

Published
2009
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128. A detailed transcript-level probe annotation reveals alternative splicing based microarray platform differences.

Author

Lee JC, Stiles D, Lu J, and Cam MC

Subjects
Cluster Analysis, Genes, Humans, Reproducibility of Results, Sensitivity and Specificity, Tumor Cells, Cultured, Alternative Splicing, DNA Probes analysis, Databases, Genetic, Gene Expression Profiling, Microarray Analysis
Abstract

Background: Microarrays are a popular tool used in experiments to measure gene expression levels. Improving the reproducibility of microarray results produced by different chips from various manufacturers is important to create comparable and combinable experimental results. Alternative splicing has been cited as a possible cause of differences in expression measurements across platforms, though no study to this point has been conducted to show its influence in cross-platform differences., Results: Using probe sequence data, a new microarray probe/transcript annotation was created based on the AceView Aug05 release that allowed for the categorization of genes based on their expression measurements' susceptibility to alternative splicing differences across microarray platforms. Examining gene expression data from multiple platforms in light of the new categorization, genes unsusceptible to alternative splicing differences showed higher signal agreement than those genes most susceptible to alternative splicing differences. The analysis gave rise to a different probe-level visualization method that can highlight probe differences according to transcript specificity., Conclusion: The results highlight the need for detailed probe annotation at the transcriptome level. The presence of alternative splicing within a given sample can affect gene expression measurements and is a contributing factor to overall technical differences across platforms.

Published
2007
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129. Long CGG-repeat tracts are toxic to human cells: implications for carriers of Fragile X premutation alleles.

Author

Handa V, Goldwater D, Stiles D, Cam M, Poy G, Kumari D, and Usdin K

Subjects
5' Untranslated Regions, Adaptor Proteins, Signal Transducing genetics, Adaptor Proteins, Signal Transducing metabolism, Annexin A5 drug effects, Annexin A5 metabolism, Ataxia genetics, Blotting, Western, Caspase 8, Caspases analysis, Caspases genetics, Caspases metabolism, Cell Line, Cell Survival, Culture Media, Serum-Free, Dose-Response Relationship, Drug, Doxycycline pharmacology, Female, Gene Expression Profiling, Gene Expression Regulation, Herbicides pharmacology, Humans, Mutation, Neurotensin genetics, Neurotensin metabolism, Oligonucleotide Array Sequence Analysis, Paraquat pharmacology, Staurosporine pharmacology, Trinucleotide Repeat Expansion genetics, Ubiquitin-Protein Ligases genetics, Ubiquitin-Protein Ligases metabolism, Alleles, Fragile X Syndrome genetics, Heterozygote, Trinucleotide Repeat Expansion drug effects
Abstract

People with 59-200 CGG.CCG-repeats in the 5' UTR of one of their FMR1 genes are at risk for Fragile X tremor and ataxia syndrome. Females are also at risk for premature ovarian failure. These symptoms are thought to be due to the presence of the repeats at the DNA and/or RNA level. We show here that long transcribed but untranslated CGG-repeat tracts are toxic to human cells and alter the expression of a wide variety of different genes including caspase-8, CYFIP, Neurotensin and UBE3A.

Published
2005
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130. The role of sequential stream segregation and frequency selectivity in the perception of simultaneous sentences by listeners with sensorineural hearing loss.

Author

Mackersie CL, Prida TL, and Stiles D

Subjects
Adult, Age Factors, Aged, Aged, 80 and over, Audiometry, Pure-Tone, Auditory Threshold, Female, Humans, Male, Middle Aged, Noise, Psychoacoustics, Severity of Illness Index, Time Factors, Hearing Loss, Sensorineural diagnosis, Speech Perception physiology
Abstract

The purpose of this study was to determine the role of frequency selectivity and sequential stream segregation in the perception of simultaneous sentences by listeners with sensorineural hearing loss. Simultaneous sentence perception was tested in listeners with normal hearing and with sensorineural hearing loss using sentence pairs consisting of one sentence spoken by a male talker and one sentence spoken by a female talker. Listeners were asked to repeat both sentences and were scored on the number of words repeated correctly in each sentence. Separate scores were obtained for the first and second sentences repeated. Frequency selectivity was assessed using a notched-noise method in which thresholds for a 1,000 Hz pure-tone signal were measured in noise with spectral notch bandwidths of 0, 300, and 600 Hz. Sequential stream segregation was measured using tone sequences consisting of a fixed frequency (A) and a varying frequency tone (B). Tone sequences were presented in an ABA&#95;ABA&#95;... pattern starting at a frequency (B) either below or above the frequency of the fixed 1,000 Hz tone (A). Initially, the frequency difference was large and was gradually decreased until listeners indicated that they could no longer perceptually separate the two tones (fusion threshold). Scores for the first sentence repeated decreased significantly with increasing age. There was a strong relationship between fusion threshold and simultaneous sentence perception, which remained even after partialling out the effects of age. Smaller frequency differences at fusion thresholds were associated with higher sentence scores. There was no relationship between frequency selectivity and simultaneous sentence perception. Results suggest that the abilities to perceptually separate pitch patterns and separate sentences spoken simultaneously by different talkers are mediated by the same underlying perceptual and/or cognitive factors.

Published
2001
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131. Why adolescent boys dream of becoming professional athletes.

Author

Stiles DA, Gibbons JL, Sebben DJ, and Wiley DC

Subjects
Adolescent, Cross-Cultural Comparison, Ethnicity psychology, Humans, Male, Motivation, United States, Aspirations, Psychological, Psychology, Adolescent, Sports psychology
Abstract

A review of studies which investigated drawings of the ideal man and the occupational aspirations of boys (ages 11-18 years) from several countries indicated that becoming a professional athlete was a popular but unrealistic aspiration for many adolescent boys. Boys who were athletes and nonathletes from diverse ethnic groups and nationalities dreamed of becoming professional athletes. In two additional studies in the United States of America, adolescents were asked why they thought boys most often selected professional athlete as a possible future occupation. Adolescents perceived professional athletes as rich, famous, and glorified. Enhancement of status and financial gain were ranked as more important than the desire to play sports.

Published
1999
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132. Bridges from welfare to work. Mercy Medical Center's program helps people in transition.

Author

Feller K and Stiles D

Subjects
Administrative Personnel, Community-Institutional Relations, Employment psychology, Housing, Humans, Ohio, Self Concept, Social Responsibility, Work, Employment organization & administration, Hospitals, Religious organization & administration, Interinstitutional Relations, Program Development, Social Support, Social Welfare
Published
1999

133. Specialty mental health services in metropolitan and nonmetropolitan areas: 1983 and 1990.

Author

Goldsmith HF, Wagenfeld MO, Manderscheid RW, and Stiles D

Subjects
Community Mental Health Services organization & administration, Humans, Organizational Innovation, Rural Health Services, United States, Urban Health Services, Community Mental Health Services trends, Health Services Accessibility, Urbanization
Abstract

This paper provides information about the changes between 1983 and 1990 in the availability and volume of specialty mental health services in counties with different levels of metropolitanization and urbanization. The analysis uses the 1983 county metropolitan and urbanization designations for both 1983 and 1990 in order to obtain an accurate determination of the changes that occurred in the 7-year period. The results indicate that during the study period, metropolitan counties experienced increasing availability of specialty mental health services, while nonmetropolitan counties did not. Implications for future rural mental health policy are discussed.

Published
1997
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134. Adolescents' opposite-sex ideal in four countries.

Author

Gibbons JL, Richter RR, Wiley DC, and Stiles DA

Subjects
Adolescent, Choice Behavior, Cross-Cultural Comparison, Female, Guatemala, Humans, Iceland, Male, Mexico, Social Values, Surveys and Questionnaires, United States, Courtship, Gender Identity, Psychology, Adolescent
Abstract

Six hundred young adolescents (11 to 16 years old) from 4 countries (Guatemala, Iceland, Mexico, and the United States) ranked the importance of 10 qualities of the opposite-sex ideal person. Those from the United States responded in an individualistic fashion; they ranked being fun, being sexy, and having considerable money as important for the ideal. Those from Guatemala responded in a collectivistic fashion; they ranked liking children as important, but being fun and good looking as unimportant. Adolescents from Mexico and Iceland reported patterns of values not clearly associated with either collectivism or individualism.

Published
1996
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135. Girls' relational self in Sri Lanka and the United States.

Author

Stiles DA, Gibbons JL, and de Silva SS

Subjects
Adolescent, Age Factors, Child, Cross-Cultural Comparison, Culture, Female, Humans, Self-Assessment, Sri Lanka, United States, Self Concept
Abstract

The self-conceptions of 100 girls (11-17 years old) from Sri Lanka and the United States were studied from the traditional Western perspective of identity development as a process in which adolescents become increasingly independent and autonomous. This perspective is based on male development in Western countries and may not adequately describe the experience of girls of non-Western adolescents, for whom relationships with others may be central to identity formation. The participating girls drew self-portraits and either answered the question "How would you describe yourself to yourself?" or completed the sentence "I am..." 20 times. The results indicate that relationships and independence are important themes for the girls from the United States and from Sri Lanka. Older girls differed from younger girls in that greater maturity was associated with greater interest in interpersonal relationships and future lives.

Published
1996
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136. Video display terminal operators: technology's biopsychosocial stressors.

Author

Stiles DD

Subjects
Humans, Occupational Health Nursing, Risk Factors, Computer Terminals, Occupational Diseases etiology, Occupational Diseases nursing, Occupational Diseases prevention & control, Stress, Physiological etiology, Stress, Physiological nursing, Stress, Physiological prevention & control
Abstract

1. Professional nurses can contribute significantly to the implementation of a multidisciplinary team to solve biopsychosocial stress issues in the "high tech" workplace. 2. Educating workers about risk factors, ergonomics, and self management measures is one of the most important aspects of preventing video display terminal related disorders. 3. The evaluation of biopsychosocial stress involves examination of workers' physical health, psychological demands, decision latitude, social support, workstation design, and other special considerations such as electronic performance monitoring.

Published
1994

137. Adolescents' views of work and leisure in The Netherlands and the United States.

Author

Stiles DA, Gibbons JL, and Peters E

Subjects
Adolescent, Aspirations, Psychological, Female, Gender Identity, Humans, Male, Netherlands, United States, Career Choice, Cross-Cultural Comparison, Leisure Activities, Personality Development, Social Values
Abstract

During early adolescence, youth begin to make choices about their future. Sundberg and Tyler (1970) found differences between adolescents in the Netherlands and the United States as to their possibilities for future occupations and leisure activities. Since there have been many changes in both countries over the past twenty-five years, the present study was designed as a replication and expansion of that research. Participants were 522 14- and 15-year-olds in the Netherlands and the United States who filled out the Sundberg and Tyler questionnaire (in the original Dutch and English forms) and drew a picture of the ideal man or woman engaged in an activity. Two-way (country by gender) ANOVAs indicated that the number of occupations listed was greater for adolescents in the Netherlands than in the United States, and that girls listed more occupations than did boys, but considered fewer occupations as actual possibilities for themselves. There was an apparent increase in the number of leisure activities listed by adolescents in the Netherlands. In the U.S., the ideal person was more often drawn as being at work (44.9%) as compared with the Netherlands (20.4%). U.S. students seemed more inclined to glamorize work; popular drawings had themes which linked work and success, achievement and wealth. Dutch students seemed to be interested in quality of life; their drawings depicted sports, relaxation, attractiveness, and humor.

Published
1993

138. Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans.

Author

Granowitz EV, Porat R, Mier JW, Pribble JP, Stiles DM, Bloedow DC, Catalano MA, Wolff SM, and Dinarello CA

Subjects
Cytokines blood, Humans, Interleukin 1 Receptor Antagonist Protein, Interleukin-6 biosynthesis, Lipopolysaccharides administration & dosage, Lymphocyte Activation, Male, Sialoglycoproteins immunology, Sialoglycoproteins pharmacokinetics, Interleukin-1 antagonists & inhibitors, Sialoglycoproteins therapeutic use
Abstract

A phase I study of human recombinant interleukin-1 receptor antagonist (IL-1ra) was conducted in healthy males between the ages of 18 and 30. Twenty-five volunteers received a single, 3 h continuous intravenous infusion of doses ranging between 1 mg/kg and 10 mg/kg IL-1ra. At 3 h into the infusion, plasma IL-1ra levels were 3.1 micrograms/ml and 29 micrograms/ml for the 1 mg/kg and 10 mg/kg doses, respectively. Post-infusion plasma IL-1ra levels declined rapidly, exhibiting an initial half-life of 21 min and a terminal half-life of 108 min. Clinical, hematological, biochemical, endocrinological and immunomodulatory effects were monitored over 72 h and compared to those of four subjects receiving a 3 h infusion of saline. There were no clinically significant differences between the drug and saline groups in symptoms, physical examinations, complete blood counts, mononuclear cell phenotypes, blood chemistry profiles, serum iron and serum cortisol levels. Peripheral blood mononuclear cells (PBMC) obtained after completion of the IL-1ra infusion synthesized significantly less interleukin 6 ex vivo than PBMC from saline-injected controls. These data suggest that transient blockade of interleukin 1 receptors is safe and does not significantly affect homeostasis.

Published
1992
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139. Girls' identity formation in the changing social structure of Sri Lanka.

Author

de Silva S, Stiles DA, and Gibbons JL

Subjects
Adolescent, Career Choice, Female, Humans, Self Concept, Social Environment, Sri Lanka, Women's Rights psychology, Developing Countries, Gender Identity, Psychology, Adolescent, Social Change
Abstract

Adolescent girls (N = 118) from diverse social backgrounds in Sri Lanka described their views of womanhood. Qualities of the ideal woman considered most important were kindness and honesty, liking children, intelligence, and having a good job. Although the traditional role of the Sri Lankan woman is that of homemaker, most girls in the study (55%) drew the ideal woman working outside the home, often as a teacher or a doctor. Nevertheless, adolescent girls emphasized traditional qualities of the woman at both work and home as self-sacrificing and serving others.

Published
1992
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140. Racial congruity as a contextual correlate of mental disorder.

Author

Tweed DL, Goldsmith HF, Jackson DJ, Stiles D, Rae DS, and Kramer M

Subjects
Adult, Age Factors, Aged, Baltimore, Female, Humans, Male, Middle Aged, Risk Factors, Sex Factors, Socioeconomic Factors, Adjustment Disorders psychology, Black or African American psychology, Depressive Disorder psychology, Social Environment, Social Support
Abstract

The effects of exposure to racially dissonant residential environments on depressive psychopathology are explored. Epidemiological survey data are shown to support the hypothesis that an inverse relationship exists between racial congruity and depression. Limitations of the analysis are discussed, as are the social implications of the findings.

Published
1990
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141. Desertification: a question of linkages.

Author

Stiles D

Subjects
Environment, Agriculture, Biology, Developing Countries, Ecology, Economics, Financial Management, International Agencies, International Cooperation, Organizations, Politics, Public Policy, Social Planning, United Nations
Published
1985

142. The food crisis and environmental conservation in Africa.

Author

Stiles D and Brennan R

Subjects
Africa, Africa South of the Sahara, Developing Countries, Economics, Environment, International Cooperation, Social Planning, Socioeconomic Factors, Agriculture, Conservation of Natural Resources, Food Supply, Health Planning Guidelines, Health Services Needs and Demand, Poverty, Public Policy, Starvation
Published
1986
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146. A film technique for assessing children's self-estimation of body size under static and dynamic conditions.

Author

Stiles DB and Smith HM

Subjects
Body Height, Child, Female, Humans, Male, Body Image, Motion Pictures, Self Concept, Self-Assessment, Size Perception
Abstract

A film technique was developed to obtain children's self-estimates of selected aspects of their own body dimensions under static and dynamic conditions. Subjects were 40 children, ranging in age from 6.10 to 10.10 yr. They estimated their own heights and shoulder widths while viewing projected images of themselves in two conditions, static and dynamic. The condition films displayed the projected image of the subject from 6 in. below to 6 in. above his or her actual height. The subject responded by stopping a remote-controlled projector when the projected image was perceived by the subject to be his or her own body dimension. A nested factorial design was utilized to determine significant main effects of age, sex, condition, and mode (direction of trials). A paired difference test indicated whether the subjects' estimates were in fact significantly different from the actual body dimensions. Analysis showed no significant differences in main effects of age or sex. Self-estimates of selected body dimensions were significantly different from actual, measured, body dimensions. The motion-picture technique was considered successful in obviating several difficulties encountered in the past by workers using other techniques and was effective in introducing dynamics as a condition under which subjects could make self-estimates of their own body dimensions.

Published
1977
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150. Organochlorine pesticide residues in a farming area, Nova Scotia--1972-73.

Author

Burns BG, Peach ME, and Stiles DA

Subjects
Agriculture, Chromatography, Gas, DDT analysis, Fresh Water analysis, Nova Scotia, Plants, Toxic, Soil analysis, Nicotiana, Insecticides analysis, Pesticide Residues analysis
Abstract

Soil, silt, and water samples from the Habitant Creek water-shed, Nova Scotia, a tobacco-growing area, have been monitored for organochlorine insecticides. Most samples contain measurable quantities of many persistent pesticides used in farming during the past decade. Sediment levels indicate that residues settle in sluggish parts of the stream. Drainage ditches show highest residual content caused in part by mass transport of soil in runoff. Residue content of water samples is normally one-tenth to one-hundredth that of silt, but is much higher during periods of heavy runoff. Levels vary with the seasons and are highest in the fall, decrease through the spring and summer, and are lowest in the winter. Although samples of well water taken fairly close to the stream showed virtually no residual content, a natural drainage reservior had a pesticide content similar to that in the stream.

Published
1975

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