101. CD71+erythroid cells promote Tregs and via ectonucleotides CD39 and CD73 modulate T cell responses
- Author
-
Shokrollah Elahi, Shima Shahbaz, and Petya Koleva
- Subjects
Immunology ,Immunology and Allergy - Abstract
CD71+erythroid cells are abundant in newborns with immunomodulatory properties. Recently, we showed a subset of neonatal CD71+erythroid cells express significant levels of V-domain Ig Suppressor of T Cell Activation (VISTA) and via TGF-β play a pivotal role in promotion of naïve CD4+T cells into regulatory T cells (PLOS Biology Dec. 2018). Here, we have demonstrated another novel immunomodulatory mechanism for CD71+erythroid cells. A subset of CD71+erythroid cells express significant levels of ectonucleotides CD39 and CD73, which culminating in the formation of adenosine. Extracellular adenosine has a marked dampening effects on the immune cells, suppressing effector T cells and assisting regulatory T cells. In addition, we found that CD71+erythroid cells express adenosine receptor (A2A) and constitutively produce TGF-β. Interestingly, exogenous or endogenous TGF-β upregulates expression of CD73 on CD71+erythroid cells. Collectively, these studies provide a novel insight into the crosstalk between CD71+ erythroid cells and regulatory T cells. Our results highlight the important biological role of CD71+erythroid cells in immune homeostasis.
- Published
- 2019