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Infection withBordetella parapertussisbut NotBordetella pertussisCauses Pertussis‐Like Disease in Older Pigs
- Source :
- The Journal of Infectious Diseases. 198:384-392
- Publication Year :
- 2008
- Publisher :
- Oxford University Press (OUP), 2008.
-
Abstract
- The 3 major Bordetella species--namely, B. pertussis, B. parapertussis, and B. bronchiseptica--can be distinguished by their different host ranges. B. bronchiseptica infects a wide range of mammals (including humans), whereas B. pertussis infects only humans and, under experimental conditions, mice and pigs. In contrast, B. parapertussis, also a causative agent of pertussis, displays a unique host specificity with 2 subgroups, one infecting only humans and the other infecting only sheep. Here, we show that both strains of B. parapertussis also infect older piglets when delivered intrapulmonarily. Infected piglets displayed mild fever and respiratory symptoms, such as coughing and breathing difficulties. Importantly, transmission was observed between infected and noninfected piglets. In tracheal organ cultures, adherence to ciliated epithelial cells was observed. Furthermore, both strains of B. parapertussis displayed higher resistance than B. pertussis to neutralization by porcine beta-defensin 1 in the respiratory tract, which has been demonstrated to be associated with protection against B. pertussis disease in older pigs. The development of this new model will assist us in better understanding the pathogenesis of this disease and in the development of more-effective vaccines against pertussis.
- Subjects :
- Bordetella pertussis
Bordetella parapertussis
beta-Defensins
Swine
Whooping Cough
Colony Count, Microbial
Biology
Microbiology
Pathogenesis
medicine
Animals
Immunology and Allergy
Lung
Whooping cough
Bordetella Infections
Swine Diseases
Transmission (medicine)
Respiratory disease
Age Factors
biology.organism_classification
medicine.disease
Virology
Trachea
Bordetella
Infectious Diseases
medicine.anatomical_structure
Respiratory tract
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 198
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....1b92d77bc81d4c5902514dc5594f34eb