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119 results on '"Saulnier, Mark"'

109. E-ring desoxy analogs of etoposide

Author

Saulnier, Mark G., primary, Vyas, Dolatrai M., additional, Langley, David R., additional, Doyle, Terrence W., additional, Rose, William C., additional, Crosswell, Alfred R., additional, and Long, Byron H., additional

Published
1989
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113. Chemoselective synthesis of allyltrimethylsilanes by cross-coupling of vinyl triflates with tris((trimethylsilyl)methyl)aluminum catalyzed by palladium(0)

Author

Min Min Tun, J. F. Kadow, D. M. Vyas, David R. Langley, and Saulnier Mark G

Subjects
Tris, Trimethylsilyl, chemistry.chemical_element, General Chemistry, Biochemistry, Catalysis, chemistry.chemical_compound, Colloid and Surface Chemistry, Sulfonate, chemistry, Polymer chemistry, Organic chemistry, Chemoselectivity, Aliphatic compound, Benzene, Palladium
Published
1989

114. Convergent approach to intermediates used for the synthesis of the enediyne structure of the esperamicins and calicheamicins

Author

D.M. Vyas, Min Min Tun, Saulnier Mark G, J. F. Kadow, and David R. Langley

Subjects
chemistry.chemical_classification, Esperamicin, Ketone, Silylation, Chemistry, Stereochemistry, Acetylide, Organic Chemistry, chemistry.chemical_element, Biochemistry, Adduct, chemistry.chemical_compound, Drug Discovery, Enediyne, Lithium, Enone
Abstract

The diynene lithium acetylide 5 adds to 2-siloxy-2-cyclohexenone 6 followed by silyl migration to produce ketone adduct 7 , an intermediate towards a simple Esperamicin core

Published
1989

115. Novel synthesis of potential bifunctional nucleic acid intercalating agantes: 1,10-bis-(6-metheyl-5H-benzo[b]carbazol-11-yl)decane

Author

Saulnier Mark G and Gordon W. Gribble

Subjects
Indole test, chemistry.chemical_compound, Bicyclic molecule, Chemistry, Nucleic acid, Molecular Medicine, Organic chemistry, Decane, Bifunctional, Aryne, Deoxygenation, Diels–Alder reaction
Abstract

The title compound, a potential DNA bis-intercalating agent, is synthesized from the novel bis-4H-furo[3,4-b]indole(7) by a double Diels–Alder reaction With benzyne followed by deoxygenation and desulphonation.

Published
1984

119. Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.

Author

Balasubramanian BN, St Laurent DR, Saulnier MG, Long BH, Bachand C, Beaulieu F, Clarke W, Deshpande M, Eummer J, Fairchild CR, Frennesson DB, Kramer R, Lee FY, Mahler M, Martel A, Naidu BN, Rose WC, Russell J, Ruediger E, Solomon C, Stoffan KM, Wong H, Wright JJ, Zimmermann K, and Vyas DM

Subjects
Animals, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Carbazoles chemistry, Carbazoles pharmacology, Glucosides chemistry, Glucosides pharmacology, Male, Mice, Neoplasm Transplantation, Solubility, Structure-Activity Relationship, Water, Xenograft Model Antitumor Assays, Antineoplastic Agents chemical synthesis, Carbazoles chemical synthesis, Glucosides chemical synthesis, Prostatic Neoplasms drug therapy, Topoisomerase I Inhibitors
Abstract

A series of fluoroindolocarbazoles were studied with respect to their topoisomerase I activity, cytotoxicity, selectivity, and in vivo antitumor activity. Emerging from this series was BMS-251873, a potential clinical candidate possessing a robust pharmacological profile including curative antitumor activity against prostate carcinoma.

Published
2004
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