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101. Italian consensus and recommendations on diagnosis and treatment of low-grade gliomas. An intersociety (SINch/AINO/SIN) document

Author

Alessandro Olivi, Bianca Pollo, Antonio Nicolato, Ugo De Paula, Tamara Ius, Miran Skrap, Maurizio Iacoangeli, Andrea Falini, Vincenzo Esposito, Carmine M. Carapella, Riccardo Soffietti, Filippo Flavio Angileri, Antonino Germanò, Antonella Castellano, Roberta Rudà, Silvio Sarubbo, Costanza Papagno, Giuseppe Lombardi, Marco Maria Fontanella, Andrea Salmaggi, Sin Neuro-Oncology Section, Antonio Silvani, Pierina Navarria, Giannantonio Spena, Maria Caffo, Alessandra Fabi, Lorenzo Bello, Aino SINch Neuro-Oncology Section, Marialaura Del Basso De Caro, Giuseppe Minniti, Andrea Pace, Alessandra Solari, Rudà, R, Angileri, F, Ius, T, Silvani, A, Sarubbo, S, Solari, A, Castellano, A, Falini, A, Pollo, B, Del Basso De Caro, M, Papagno, C, Minniti, G, De Paula, U, Navarria, P, Nicolato, A, Salmaggi, A, Pace, A, Fabi, A, Caffo, M, Lombardi, G, Carapella, C, Spena, G, Iacoangeli, M, Fontanella, M, Germanò, A, Olivi, A, Bello, L, Esposito, V, Skrap, M, Soffietti, R, Rudá, Roberta, Angileri, Filippo F, Ius, Tamara, Silvani, Antonio, Sarubbo, Silvio, Solari, Alessandra, Castellano, Antonella, Falini, Andrea, Pollo, Bianca, Del Basso De Caro, Marialaura, Papagno, Costanza, Minniti, Giuseppe, De Paula, Ugo, Navarria, Pierina, Nicolato, Antonio, Salmaggi, Andrea, Pace, Andrea, Fabi, Alessandra, Caffo, Maria, Lombardi, Giuseppe, Carapella, Carmine M, Spena, Giannantonio, Iacoangeli, Maurizio, Fontanella, Marco, Germanó, Antonino F, Olivi, Alessandro, Bello, Lorenzo, Esposito, Vincenzo, Skrap, Miran, and Soffietti, Riccardo

Subjects
medicine.medical_specialty, Neurology, Consensus, MEDLINE, Health planning guidelines, Consensu, Medical Oncology, Patient care, Health planning guideline, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Medical physics, Surgical treatment, Societies, Medical, Disease trajectory, business.industry, Task force, Brain Neoplasms, Neuropsychology, Glioma, Glioma, Consensus, Health planning guidelines, Italy, 030220 oncology & carcinogenesis, Surgery, Neurology (clinical), Neurosurgery, business, 030217 neurology & neurosurgery
Abstract

In 2018, the SINch (Italian Society of Neurosurgery) Neuro-Oncology Section, AINO (Italian Association of Neuro-Oncology) and SIN (Italian Association of Neurology) Neuro-Oncology Section formed a collaborative Task Force to look at the diagnosis and treatment of low-grade gliomas (LGGs). The Task Force included neurologists, neurosurgeons, neuro-oncologists, pathologists, radiologists, radiation oncologists, medical oncologists, a neuropsychologist and a methodologist. For operational purposes, the Task Force was divided into five Working Groups: diagnosis, surgical treatment, adjuvant treatments, supportive therapies, and follow-up. The resulting guidance document is based on the available evidence and provides recommendations on diagnosis and treatment of LGG patients, considering all aspects of patient care along their disease trajectory.

Published
2020

102. The management of epilepsy in clinical practice: Do the needs manifested by the patients correspond to the priorities of the caring physicians? Findings from the EPINEEDS Study

Author

Giorgia Giussani, Gabriele Enia, Elisa Bianchi, Oriano Mecarelli, Ettore Beghi, Patrizia Pulitano, Claudia Cagnetti, Sara Baldinelli, Simona Lattanzi, Angela La Neve, Maria Tappatà, Teresa Francavilla, Giovanni De Maria, Vito Sofia, Loretta Giuliano, Greta Mainieri, Daniela Fatuzzo, Vincenzo Belcastro, Maurizio Elia, Giuseppe D'Orsi, Alessandra Lalla, Andrea Salmaggi, Francesco Brigo, Adriana Magaudda, Francesco Pisani, Santi Galletta, Laura R. Pisani, Massimo Raffaele, Domenico Cosenza, Flavio S. Villani, Rui M.M. Quintas, Rosa Cervellione, Simona Borroni, Stefano Meletti, Carlo Ferrarese, Giuseppina Barbella, Jacopo Di Francesco, Graziella Bogliun, Simone Beretta, Carlo A. Galimberti, Teresa A. Cantisani, Michela Cecconi, Maria G. Celani, Rossella Papetti, Filippo S. Giorgi, Umberto Aguglia, Sara Gasparini, Edoardo Ferlazzo, Paolo Manganotti, Giovanni Crichiutti, Giulia Bravar, Giussani, G., Enia, G., Bianchi, E., Mecarelli, O., Beghi, E., Pulitano, P., Cagnetti, C., Baldinelli, S., La Neve, A., Tappata, M., Francavilla, T., De Maria, G., Sofia, V., Giuliano, L., Mainieri, G., Fatuzzo, D., Belcastro, V., Elia, M., D'Orsi, G., Lalla, A., Salmaggi, A., Brigo, F., Magaudda, A., Pisani, F., Galletta, S., Pisani, L. R., Raffaele, M., Cosenza, D., Villani, F. S., Quintas, R. M. M., Cervellione, R., Borroni, S., Meletti, S., Ferrarese, C., Barbella, G., Di Francesco, J., Bogliun, G., Beretta, S., Galimberti, C. A., Cantisani, T. A., Cecconi, M., Celani, M. G., Papetti, R., Giorgi, F. S., Aguglia, U., Gasparini, S., Ferlazzo, E., Manganotti, P., Crichiutti, G., Bravar, G., Giussani, G, Enia, G, Bianchi, E, Mecarelli, O, Beghi, E, Pulitano, P, Cagnetti, C, Baldinelli, S, La Neve, A, Tappata, M, Francavilla, T, De Maria, G, Sofia, V, Giuliano, L, Mainieri, G, Fatuzzo, D, Belcastro, V, Elia, M, D'Orsi, G, Lalla, A, Salmaggi, A, Brigo, F, Magaudda, A, Pisani, F, Galletta, S, Pisani, L, Raffaele, M, Cosenza, D, Villani, F, Quintas, R, Cervellione, R, Borroni, S, Meletti, S, Ferrarese, C, Barbella, G, Di Francesco, J, Bogliun, G, Beretta, S, Galimberti, C, Cantisani, T, Cecconi, M, Celani, M, Papetti, R, Giorgi, F, Aguglia, U, Gasparini, S, Ferlazzo, E, Manganotti, P, Crichiutti, G, and Bravar, G

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Activities of daily living, Adolescent, Patients, Concordance, Satisfaction, Need, Disease, 03 medical and health sciences, Behavioral Neuroscience, Psychiatric comorbidity, Epilepsy, Young Adult, 0302 clinical medicine, Genetic etiology, Seizures, Physicians, Surveys and Questionnaires, Medicine, Humans, Epilepsy Needs, 030212 general & internal medicine, Aged, Aged, 80 and over, Health Services Needs and Demand, Physician-Patient Relations, business.industry, Prioritie, Communication, Needs, Priorities, Disease Management, Middle Aged, medicine.disease, Clinical Practice, Cross-Sectional Studies, Neurology, Italy, Socioeconomic Factors, Etiology, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Purpose The purpose of this study was to assess the priorities of patients with epilepsy and caring physicians and the correspondence between these priorities. Methods In this multicenter cross-sectional study, patients with epilepsy attending 21 Italian epilepsy centers and their caring physicians filled anonymously questionnaires on the needs and priorities in the management of the disease. Included were questions on patients' demographics, diagnosis, treatment, and outcome of epilepsy. The concordance between patients and their physicians was assessed on various aspects of the diagnosis and care of the disease. Patients' satisfaction with communication, services, and patient–doctor relationship was also assessed. Results Included were 432 women and 355 men aged 15 to 88 years (median: 41 years). Disease duration ranged from 6 months to 75 years. A structural/metabolic etiology predominated (52.7%), followed by a (presumed) genetic etiology (33.0%). Seizure remission was present in 56.5% of cases. Comorbidities requiring chronic treatment were present in 27.5%, and comorbidities affecting self-sufficiency in 9.5%. Psychiatric comorbidity was present in 35.0%. Patients' priorities included discovery of the cause (89.1%), use of right drug (98.7%), use of a drug without chronic side effects (94.0%), and a life without restrictions (90.4%). Physicians' priorities included choice of right drug (83.5%) and use of drugs without chronic side effects (86.8%). Priorities varied with patients' age, sex, education, and occupation. Patient–doctor relationships were at least good in most cases. The information imparted was considered unsatisfactory by 21–44% of cases on seizure circumstances and complications, side effects of drugs, limitations of daily activities, and management of physiologic or pathologic conditions. Patients declared overall satisfaction, except for appointments (21.5%) and emergencies (30.8%). Conclusion Patients and physicians' priorities in the management of epilepsy overlap only in part. Patients are satisfied with their caring physicians and less satisfied with communication and management of routine and emergency problems.

Published
2020

104. Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes)

Author

Easton, J. Donald, Aunes, Maria, Albers, Gregory W., Amarenco, Pierre, Bokelund-Singh, Sara, Denison, Hans, Evans, Scott R., Held, Peter, Jahreskog, Marianne, Jonasson, Jenny, Minematsu, Kazuo, Molina, Carlos A., Wang, Yongjun, Wong, K.S. Lawrence, Johnston, S. Claiborne, Ameriso, Sebastiá F., Donnan, Geoffrey, Lemmens, Robin, Massaro, Ayrton, Titianova, Ekaterina, Hill, Michael D., Lavados, Pablo, Skoloudik, David, Röther, Joachim, Norbert, Szegedi, Agnelli, Giancarlo, Bornstein, Natan, Tanahashi, Norio, Góngora, Angel Arauz, Pretell, Edwin, San Jose, Maria Cristina Z., Czlonkowska, Anna, Bajenaru, Ovidiu, Stakhovskaya, Ludmila, Brozman, Miroslav, Kim, Jong-Sung, Wahlgren, Nils, Michel, Patrik, Lee, Tsong Hai, Suwanwela, Nijasri Charnnarong, Kutluk, Kursad, Moskovko, Sergii, Kasner, Scott, Laskowitz, Daniel, Clark, Wayne, Nguyen, Huy Thang, Ameriso, Sebastian, Lepera, Sandra, Romano, Marina, Paulon, David, Ioli, Pablo, Zurru, Cristina, Bruera, Guadalupe, Jure, Lorena, Klein, Francisco, Povedano, Guillermo, Levi, Christopher, Phan, Thanh, Markus, Romesh, Anderson, Craig, Sabet, Arman, Davis, Stephen, Lee, Andrew, Kleinig, Timothy, Wong, Andrew, Krause, Martin, Jannes, Jim, Wijeratne, Tissa, Lemmens, Robin, Hemelsoet, Dimitri, Peeters, André, Tack, Philippe, Vanacker, Peter, Laloux, Patrice, Van Landegem, William, Vanhooren, Geert, Desfontaines, Philippe, Van Orshoven, Marc, Oliveira, Fabio, Friedrich, Mauricio, Brondani, Rosane, Gagliardi, Rubens, Fabio, Soraia, Dracoulakis, Marianna, Bazan, Rodrigo, Marrone, Luiz, Pontes Neto, Octavio, Silva, Gisele, Kowacs, Pedro, Titianova, Ekaterina, Stamenova, Paraskeva, Daskalov, Marin, Staikov, Ivan, Baldaranov, Dimo, Maslarov, Dimitar, Lilovski, Hristo, Petkov, Plamen, Petrova, Neli, Mavrov, Radoslav, Markova, Veska, Petrova, Valeria, Beleva, Tanya, Kralev, Borislav, Sotirov, Nikolay, Lekova, Veska, Hristov, Dimcho, Ermenkova, Vera, Mateev, Lyudmil, Mitkova, Rumeliya, Haralanov, Liybomir, Ikonomov, Rosen, Mihailova, Margarita, Georgiev, Ivan, Shuaib, Ashfaq, Hachinski, Vladimir, Boulanger, Jean-Martin, Mann, Sharan, Hassan, Ayman, Mackey, Ariane, Menon, Bijoy, Minuk, Jeffrey, Siddiqui, Muzaffar, Eustace, Marsha, Vieira, Lucia, Selchen, Daniel, Beaudry, Michel, Stotts, Grant, Lavados, Pablo, Castro, Angel, Gasic, Kristo, Rivas, Rodrigo, Sanchez, Pablo, Roldan, Andres, Grossmann, Ingrid, Figueroa, Christian, Li, Jimei, Xu, Xiaolin, Chen, Huisheng, Li, Xiaohong, Yang, Yi, Zhang, Chunsheng, Wang, Baojun, Li, Guanglai, Wang, Dong, Lin, Hong, Tang, Yamei, Xu, Anding, Wang, Yanjiang, Hong, Wenke, Song, Zhi, Zhang, Xu, Jin, Xiaoping, Xu, Yun, Yan, Fuling, Zheng, Weihong, Wang, Xiaoping, Dong, Qiang, Zhao, Zhongxin, Zhang, Baorong, Zhong, Wangtao, Wen, Guoqiang, Xu, Jun, Li, Guozhong, Dong, Xueshuang, Tian, Xiangyang, Zhang, Zhaohui, Xu, En, Liu, Kaixiang, Chen, Jun, Skoda, Ondrej, Skoloudik, David, Ehler, Edvard, Vaclavik, Daniel, Sanak, Daniel, Klimosova, Sylva, Vitkova, Eva, Fiksa, Jan, Mikulik, Robert, Neumann, Jiri, Plny, Richard, Leys, Didier, Sibon, Igor, Mas, Jean-Louis, Alamowitch, Sonia, Pico, Fernando, Hosseini, Hassan, Mahagne, Marie-Hélène, Touze, Emmanuel, Vadot, Wilfried, Vannier, Stéphane, Nighoghossian, Norbert, Samson, Yves, Garnier, Pierre, Ellie, Emmanuel, Guillon, Benoît, Timsit, Serge, Giroud, Maurice, Philippeau, Frédéric, Bagan-Triquenot, Aude, Wolff, Valérie, Raposo, Nicolas, Obadia, Michel, Debiais, Severine, Grimaud, Jérôme, Illouz, Stéphane, Smadja, Didier, Urbanczyk, Cédric, Röther, Joachim, Berrouschot, Jörg, Weimar, Christian, Gahn, Georg, Soda, Hassan, Klimpe, Sven, Nabavi, Darius, Glahn, Jörg, Köhrmann, Martin, Krause, Lars, Terborg, Christoph, Urban, Peter, Steiner, Thorsten, Ferbert, Andreas, Dziewas, Rainer, Seidel, Günter, Thomalla, Götz, Li, Richard, Fong, Wing Chi, Cheung, Raymond, Szegedi, Norbert, Pozsegovits, Krisztián, Valikovics, Attila, Pánczél, Gyula, Rózsa, Csilla, Németh, László, Diószeghy, Péter, Óváry, Csaba, Csányi, Attila, Kerényi, Levente, Nagy, Valéria, Komoly, Sámuel, Bereczki, Dániel, Molnár, Sándor, Kondákor, István, Tanne, David, Raphaeli, Guy, Telman, Gregory, Bornstein, Natan, Leker, Ronen, Lampl, Yair, Agnelli, Giancarlo, Corea, Francesco, Ricci, Stefano, Guidetti, Donata, Malferrari, Giovanni, Marcheselli, Simona, Micieli, Giuseppe, Zini, Andrea, Di Lazzaro, Vincenzo, Gandolfo, Carlo, Salmaggi, Andrea, Tassi, Rossana, Rasura, Maurizia, Orlandi, Giovanni, Comi, Giancarlo, Ricci, Stefano, Mancuso, Michelangelo, Delodovici, Marialuisa, Bovi, Paolo, Consoli, Domenico, Utsugisawa, Kimiaki, Fujita, Tsuneo, Kurihara, Hideyuki, Maruki, Chikashi, Hayashi, Takeshi, Ogiichi, Tsuneaki, Kumagai, Morio, Takenaka, Katsunobu, Toyoda, Kazunori, Takamatsu, Kazuhiro, Ogami, Ryo, Kin, Shigenari, Aoki, Takeshi, Takizawa, Katsumi, Omori, Shigehiro, Umezawa, Takehiko, Toba, Yasuyuki, Nonoyama, Yutaka, Nakagawa, Hidemitsu, Naka, Takashi, Morimoto, Masanori, Matsumoto, Shuichi, Hitotsumatsu, Tsutomu, Shingaki, Tatsuya, Okuda, Satoshi, Ota, Mamoru, Sakai, Nobuyuki, Yamada, Takeshi, Niwa, Jun, Fujita, Hitoshi, Moriki, Akihito, Yoshino, Kimihiro, Fukushima, Yoshihisa, Mori, Takahisa, Sato, Atsushi, Kusano, Yoshikazu, Kubo, Michiya, Yamazaki, Masashi, Ooasa, Takao, Nishizaki, Takafumi, Kitagawa, Naoki, Yasaka, Masahiro, Manabe, Yasuhiro, Yoshioka, Akira, Ishihara, Masayuki, Kagawa, Takato, Ichihashi, Toshikazu, Matsuoka, Hideki, Ito, Yasuhiro, Yamasaki, Masahiro, Takaba, Hitonori, Saito, Hisatoshi, Sato, Masahiro, Fukuda, Kazumasa, Endo, Sumio, Kidooka, Minoru, Umemura, Toshitaka, Kikkawa, Yuriko, Toru, Shuta, Yamada, Kentaro, Sakai, Hideki, Asari, Jun, Ezura, Masayuki, Nitta, Hisashi, Nagano, Keiko, Ochiai, Jun, Sakai, Keiichi, Kobayashi, Yasutaka, Yoshii, Yasuhiro, Miake, Hirotomo, Takita, Tomohiro, Taniguchi, Hidekazu, Kuroki, Kazuhiko, Mizota, Takamitsu, Yamamoto, Kenichi, Nakane, Hiroshi, Iwanaga, Takeshi, Chiba, Kei, Yoshimoto, Tetsuyuki, Torii, Tsuyoshi, Kitagawa, Takeo, Takashima, Hiroshi, Shirasaki, Naoki, Dehara, Makoto, Wada, Naomichi, Hamada, Kensuke, Kato, Noriyuki, Go, Yoshinori, Izumi, Ichiro, Ninomiya, Hirotomo, Kumai, Junichiro, Nakajima, Yoshikazu, Kaku, Yasuhiko, Isayama, Yukihiro, Kawanishi, Masahiro, Noda, Shinya, Yamamoto, Kazuhide, Hazama, Takanori, Takahashi, Hiroshi, Tanaka, Yohei, Hata, Takashi, Kazekawa, Kiyoshi, Furui, Eisuke, Hondo, Hideki, Sato, Nobuyuki, Kusunoki, Katsusuke, Nanri, Kazunori, Abe, Satoshi, Sasaoka, Noboru, Kuroyanagi, Takayuki, Suzuki, Hisahiko, Fukuyama, Kouzou, Nakahara, Kimihiro, Gongora, Fernando, Góngora, Angel Arauz, Cantú Brito, Carlos, Villarreal Careaga, Jorge, Vazquez Alfaro, Rosalia, Aguayo Leytte, Geronimo, Berrospi, Percy, Chavez, Carlos, Pretell, Edwin, Rodriguez, Liliana, Custodio, Nilton, Castañeda, Cesar, Perez, Julio, San Jose, Maria Cristina, Baroque, Alejandro, Collantes, Epifania, Aquino, Abdias, Díaz, Alejandro, Roxas, Artemio, Jr, Lokin, Johnny, Advincula, Joel, Calderon, Emerito, Navarro, Jose, Hiyadan, John, Surdilla, Arturo, Czlonkowska, Anna, Ryglewicz, Danuta, Krychowiak, Grzegorz, Fryze, Waldemar, Sobolewski, Piotr, Nowak, Ryszard, Fiszer, Urszula, Papierowska, Beata, Zielińska-Turek, Justyna, Lasek-Bal, Anetta, Kołodziejska, Ewa, Kamińska, Anna, Adamkiewicz, Bożena, Tutaj, Andrzej, Szkopek, Dorota, Musiatowicz, Krzysztof, Bąk, Zbigniew, Brzozowski, Sławomir, Brola, Waldemar, Ferens, Antoni, Zalisz, Marek, Rejdak, Konrad, Rudzińska, Monika, Bajenaru, Ovidiu, Panea, Cristina, Simu, Mihaela, Balasa, Rodica, Cuciureanu, Iulian, Popescu, Bogdan, Sabau, Monica, Roman-Filip, Corina, Pimenov, Leonid, Gekht, Alla, Milto, Anna, Shchukin, Ivan, Parfenov, Vladimir, Stakhovskaya, Liudmila, Arkhipov, Mikhail, Sokolova, Nadezhda, Bogdanov, Enver, Esin, Radiy, Khasanova, Dina, Golikov, Konstantin, Melnikova, Elena, Zaslavskiy, Leonid, Voznyuk, Igor, Nazarov, Alexander, Akhmadeeva, Leila, Iakupova, Aida, Shamalov, Nikolay, Belskaya, Galina, Chuprina, Svetlana, Denisova, Olga, Drozdova, Ekaterina, Karakulova, Yuliya, Sholomov, Ilya, Spirin, Nikolay, Vostrikova, Elena, Mordvintseva, Elena, Grigoryeva, Vera, Zateyshchikov, Dmitry, Gorbachev, Vladimir, Chefranova, Zhanna, Dudarev, Mikhail, Nilk, Rostislav, Rozhdestvenskiy, Alexey, Gurcik, Ladislav, Dvorak, Miloslav, Krastev, Georgi, Kurca, Egon, Vyletelka, Juraj, Brozman, Miroslav, Kim, Jong Sung, Bae, Hee-Joon, Kim, Yong-Won, Kim, Joon-Tae, Cha, Jae-Kwan, Nam, Hyo Suk, Chang, Dae-Il, Lee, Yong-Seok, Oh, Kyungmi, Yu, Sung-Wook, Sohn, Sung-Il, Lee, Jun, Cho, Han Jin, Kim, Eung-Gyu, Rha, Joung-Ho, Kim, Seo Hyun, Molina Cateriano, Carlos, Serena Leal, Joaquín, Vivancos Mora, José, Rodríguez Yañez, Manuel, Roquer González, Jaume, Purroy García, Francisco, Gomis Cortina, Meritxell, Masjuan Vallejo, Jaime, Arenillas Lara, Juan, Segura Martín, Tomás, Herrero, José Antonio Egido, Tembl Ferrairó, Jose Ignacio, Gállego Culleré, Jaime, Moniche Álvarez, Francisco, Steinberg, Anna, Callander, Margarita, Laska, Ann Charlotte, Bokemark, Lena, Mooe, Thomas, Käll, Tor-Björn, Welin, Lennart, Sjöblom, Lars, Hambraeus, Joakim, Teichert, Jörg, Wannberg, Hans, Sanner, Johan, Ramströmer, Bo, Ziedén, Bo, Hau, Stefan Olsson, Gustafsson, Claes, Michel, Patrik, Kahles, Timo, Lyrer, Philippe, Arnold, Marcel, Liesch, Martin, Medlin, Friedrich, Cereda, Carlo, Kägi, Georg, Luft, Andreas, Carrera, Emmanuel, Lee, Tsong-Hai, Po, Helen L., Chern, Chang-Ming, Lien, Li-Ming, Chan, Lung, Liu, Chung-Hsiang, Wu, Shey-Lin, Lee, Jiann-Der, Chen, Chih-Hung, Lin, Huey-Juan, Lin, Ruey-Tay, Chen, Wei-Hsi, Sun, Yu, Suwanwela, Nijasri Charnnarong, Tantirittisak, Tasanee, Muengtaweepongsa, Sombat, Nilanont, Yongchai, Tiamkao, Somsak, Udommongkol, Chesda, Watcharasaksilp, Kanokwan, Jantararotai, Witoon, Kutluk, Kursad, Sirin, Hadiye, Ince, Birsen, Asil, Talip, Arsava, Murat, Incesu, Tulay Kurt, Tireli, Hulya, Kucukoglu, Hayriye, Ak, Fikri, Unal, Ali, Ozturk, Serefnur, Uzuner, Nevzat, Chmyr, Galyna, Lebedynets, Volodymyr, Nikonov, Vadym, Shulga, Lyudmyla, Smolanka, Volodymyr, Moskovko, Sergii, Khavunka, Marta, Yavorska, Valentyna, Tomakh, Nataliya, Kozyolkin, Olexandr, Litovaltseva, Galyna, Lansberg, Maarten, Bernstein, Richard, Brown, David, Clark, Wayne, Dissin, Jonathan, Graffagnino, Carmelo, Harris, Jonathan, Hicks, William, Kasner, Scott, Katzan, Irene, Kramer, Jeffrey, Willey, Joshua, Silliman, Scott, Starkman, Sidney, Thaler, David, Tremwel, Margaret, Concha, Mauricio, Rajamani, Kumar, Dandapani, Bhuvaneswari, Silver, Brian, Deal, Nathan, Chang, Ira, Hassan, Ameer, Rudolph, Steven, Fischer, Kenneth, Kirshner, Howard, Logan, William, Mallenbaum, Sidney, Hefzy, Hebah, Latorre, Julius, Levine, Steven, Ciabarra, Anthony, Dafer, Rima, Anyanwu, Benjamin, Cherian, Laurel, Panezai, Spozhmy, Khanna, Anna, Dodds, Jodi, Torbey, Michel, Gebel, James, Woo, Henry, Chiu, David, Androulakis, Xiao, Burgin, William, Pineda, Maria, Yilmaz, Engin, Altafullah, Irfan, Boutwell, Christine, Cruz-Flores, Salvador, Sapkota, Biggya, Fayad, Pierre, Jacoby, Michael, Rafiq, Shahid, Salgado, Efrain, Lafranchise, Eugene, Felton, Warren, Madhavan, Ramesh, Zaidat, Osama, Pieper, Connie, Riviello, Ralph, Burnett, Aaron, Fischer, Michelle, Gentile, Nina, Calder, Christopher, Dietrich, Dennis, Cross, Jonathan, Blankenship, Larry, Dafer, Rima, Montoya, Liliana, Grogan, Wendell, Young, Mark, Khan, Farrukh, Campbell, Duane, Daboul, Nizar, Espinoza, Andrey, Cullis, Paul, Concepcion, Gilberto, Wulff, John, Afzal, Haider, Jaffrani, Naseem, Reiter, William, Arshad, Tamjeed, Lukovits, Timothy, Welker, James, Chang, Fen Lei, Badruddin, Aamir, Babikian, Viken, Menon, Ravi, Sander, James, Springer, Mellanie, Nanda, Ashish, Mas, Luis, Rajan, Raj, Silverman, Bruce, Hefzy, Hebah, Huang, David, Carpenter, David, Clark, Joni, Ching, Marilou, Santhakumar, Sunitha, Gould, Jeffrey, Bansal, Vibhav, Vidal, Gabriel, Mikesell, Timothy, Brick, John, French, William, Shah, Qaisar, Holmstedt, Christine, Ishag-Osman, Nadir, Kostis, John, Shehadeh, Abbas, Sethi, Pramodkumak, Imam, Asher, Mccomas, Carl, Tran, Duc, Gebreyohanns, Mehari, Wiseman, Brian, Malik, Maheen, Schwarcz, Aron, Altschul, Dorothea, Castaldo, John, Alshekhlee, Amer, Gancher, Stephen, Krish, Nagesh, Nguyen-Huynh, Mai, Tremwell, Margaret, Sharma, Jitendra, Lee, Lance, Neil, William, Siddiqui, Fazeel, Malek, Ali, Romero, Charles, Huy, Thang Nguyen, Hoang, Hoa, Nguyen, Thang, Nguyen, Anh, and Nguyen, Hung

Published
2017
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105. Antiepileptic drug discontinuation by people with epilepsy in the general population

Author

Giussani, Giorgia, Bianchi, Elisa, Canelli, Valentina, Erba, Giuseppe, Franchi, Carlotta, Nobili, Alessandro, Sander, Josemir W., Beghi, Ettore, Agostoni, Elio, Airoldi, Larissa, Basso, Francesco, Carpanelli, Marialuisa, Di Stefano, Mariolina, Magnoni, Andrea, Martinelli, Ottaviano, Rigamonti, Andrea, Salmaggi, Andrea, Stanzani, Lorenzo, Volpe, Cristina, Zanotta, Nicoletta, Zucca, Claudio, Agudio, Marco, Arienti, Flavio, Arrigoni, Graziano Rocco, Balestra, Giancarlo, Ballabio, Piercarla, Balossi, Stefano Marco, Baratti, Maria Rita, Barteselli, Fabrizia Enrica, Bellani, Fausto, Bellani, Mauro, Bellini, Gianpiero, Beretta, Pier Aldo, Beretta, Roberto, Bergamini, Massimo, Bertella, Annalisa, Bertolini, Francesco, Bevilacqua, Rolando, Bianchi, Marcellino Arturo, Bigiolli, Patrizia, Binda, Giuseppe, Biondelli, Gigliola, Bodega, Libero, Bolis, Edoardo Giovanni, Vincenzo, Marco, Bolla, Carlo, Bonacina, Carlo Ambrogio, Bonfanti, Marco, Borghetti, Fausta, Brambilla, Roberto, Brancaleone, Wilma, Brusadelli, Francesco, Bub, Sabine, Caccia, Giovanna, Caglio, Myriam, Rossi, Carlo Calvi, Capra, Daniela, Carone, Davide, Carì, Giuseppe, Carrera, Silvio, Cavenago, Rosalia, Cecchetti, Maria Luisa, Centonze, Bice Antonella, Cereghini, Fabio, Cerrone, Ciro, Ciappetta, Maria Pia, Cogliati, Bruno, Colombano, Ombretta, Colombo, Alberto, Colombo, Daniela, Corti, Maria Lia, Cremonini, Nicla, Crippa, Marco, Crippa, Rolando Antonio, Crotta, Mario, Curto, Salvatore, Daielli, Patrizia, De Gilio, Domenico, De Pascalis, Giuseppe Pasquale, Decet, Elena, Della Morte, Luigi, Duvia, Felice, Favorito, Antonia, Ferrario, Roberto, Fezzi, Luigi, Laura Finzi, Angela, Fiorentino, Bruno Ugo, Fornaciari, Agnese, Franceschetti, Silvana, Fulconis, Fabio, Fumagalli, Giovanni, Fumagalli, Maurizio, Galbiati, Giuseppe, Andrea Galimberti, Carlo, Gecchele, Donatella, Ghiazza, Barbara, Ghislanzoni, Paolo, Gioffredi, Laura, Hassibi, Taraneh, Julita, Simone, Leone, Giuseppe, Levi, Claudio, Locatelli, Giovanni, Locati, AnnaAlessandra, Longhi, Enrico Giovanni, Lukacova, Ingrid, Manfroi, Mauro Giovanni, Manzoni, Paola, Marcolini, Claudio, Minicucci, Fabio, Martini, Mohammed Safwan, Masperi, Rita, Mayan, Sussele, Mazzoleni, Valeria, Menga, Antonio, Merlini, Fiorella, Messina, Enrico, Micheli, Marta, Micò, Rocco, Millul, Andrea, Montini, Barbara, Palazzuolo, Alberto, Panzeri, Silvano Primo, Passoni, Giovanni, Pensotti, Laura, Petrone, Maria Marcella, Pezzuto, Roberto, Pigazzini, Elisabetta, Pirovano, Nicoletta, Pontiggia, Margherita, Pozzi, Roberto, Quadrelli, Carlo, Rampello, Filomena, Realini, Marco, Righetti, Giovanni, Ripa, Cesare, Rivetta, Sonia, Romeo, Antonino, Rota, Carlo, Rusconi, Tiziana, Santarpia, Andrea, Santi, Ivana, Sciani, Luigi, Scoccimarro, Gianni, Scopinaro, Eugenio, Semerano, Angelo Giuseppe, Sferco, Daniela, Sirtori, Anna Ersilia, Spandri, Angela, Spinelli, Bruno, Stefanoni, Fausto, Taiana, Raffaele, Tamagnini, Libero, Tassi, Laura, Tentori, Giorgio, Teodoro, Augusto, Tinterova, Katerina, Tocchetti, Ampelio, Todeschini, Michela, Trezza, Lorenzo, Valsecchi, Valter, Vanini, Roberto, Vercelloni, Claudio Felice, Villella, Anna, Viola, Maria, Vismara, Pietro, and Zoboli, Daniele Mario

Published
2017
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106. Erratum to: The Italian Registry of Endovascular Treatment in Acute Stroke: rationale, design and baseline features of patients

Author

Mangiafico, Salvatore, Pracucci, Giovanni, Saia, Valentina, Nencini, Patrizia, Inzitari, Domenico, Nappini, Sergio, Vallone, Stefano, Zini, Andrea, Fuschi, Maurizio, Cerone, Davide, Bergui, Mauro, Cerrato, Paolo, Gandini, Roberto, Sallustio, Fabrizio, Saletti, Andrea, De Vito, Alessandro, Romano, Daniele G., Tassi, Rossana, Causin, Francesco, Baracchini, Claudio, Piano, Mariangela, Motto, Cristina, Ciccone, Alfonso, Gasparotti, Roberto, Magoni, Mauro, Giorgianni, Andrea, DeLodovici, Marialuisa, Cavasin, Nicola, Critelli, Adriana, Gallucci, Massimo, Carolei, Antonio, Meloni, Teodoro, Corso, Giovanni, Vaudano, Giacomo, Duc, Enrica, Zappoli, Federico, Cavallini, Anna, Padolecchia, Riccardo, Tassinari, Tiziana, Longoni, Marco, Salmaggi, Andrea, Zampieri, PierGiuseppe, Bovi, Paolo, Puglioli, Michele, Chiti, Alberto, Guidetti, Giulio, Simonetti, Luigi, Procaccianti, Gaetano, Menozzi, Roberto, Scoditti, Umberto, Ricciardi, Fabrizio, Pezzella, Francesca R., Guarnieri, Gianluigi, Andreone, Vincenzo, and Toni, Danilo

Published
2015
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107. The Italian Registry of Endovascular Treatment in Acute Stroke: rationale, design and baseline features of patients

Author

Mangiafico, Salvatore, Pracucci, Giovanni, Saia, Valentina, Nencini, Patrizia, Inzitari, Domenico, Nappini, Sergio, Vallone, Stefano, Zini, Andrea, Fuschi, Maurizio, Cerone, Davide, Bergui, Mauro, Cerrato, Paolo, Gandini, Roberto, Sallustio, Fabrizio, Saletti, Andrea, De Vito, Alessandro, Romano, Daniele G., Tassi, Rossana, Causin, Francesco, Baracchini, Claudio, Piano, Mariangela, Motto, Cristina, Ciccone, Alfonso, Gasparotti, Roberto, Magoni, Mauro, Giorgianni, Andrea, DeLodovici, Marialuisa, Cavasin, Nicola, Critelli, Adriana, Gallucci, Massimo, Carolei, Antonio, Meloni, Teodoro, Corso, Giovanni, Vaudano, Giacomo, Duc, Enrica, Zappoli, Federico, Cavallini, Anna, Padolecchia, Riccardo, Tassinari, Tiziana, Longoni, Marco, Salmaggi, Andrea, Zampieri, PierGiuseppe, Bovi, Paolo, Puglioli, Michele, Chiti, Alberto, Guidetti, Giulio, Simonetti, Luigi, Procaccianti, Gaetano, Menozzi, Roberto, Scoditti, Umberto, Ricciardi, Fabrizio, Pezzella, Francesca R., Guarnieri, Gianluigi, Andreone, Vincenzo, and Toni, Danilo

Published
2015
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108. Headache in cerebral venous thrombosis

Author

Angelo Aliprandi, Valeria Polonia, Paolo Borelli, and Andrea Salmaggi

Subjects
medicine.medical_specialty, Neurology, Dermatology, Disease, Cranial Sinuses, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Humans, 030212 general & internal medicine, Intensive care medicine, Stroke, Neuroradiology, Venous Thrombosis, business.industry, Headache, General Medicine, medicine.disease, Psychiatry and Mental health, Venous thrombosis, Neurology (clinical), Neurosurgery, Intracranial Thrombosis, Differential diagnosis, business, 030217 neurology & neurosurgery
Abstract

Headache has been consistently reported as the most common symptom of cerebral venous thrombosis and as the most frequent presenting feature. It is often the heralding symptom, preceding other manifestations of the disease by days or even weeks. This aspect highlights the importance of recognizing headache due to cerebral venous thrombosis, as early recognition of the disease can lead to a rapid diagnosis with appropriate imaging techniques and as early treatment with heparin can dramatically change the course of the disease and alter the prognosis. Unfortunately, although common, the headache has no specific features, and the clinical presentation of CVT is highly variable, making the correct diagnosis in the emergency setting a challenging task for clinicians, even in the case of highly specialized ones such as neurologists. In this review, we will briefly summarize the epidemiology and physiopathology of CVT, and then we will discuss in more details the causes, features, and course of headache, focusing on its relevance for differential diagnosis and on red flags that should suggest the possibility of CVT as the cause of the headache.

Published
2020

109. MR-Spectroscopy and Survival in Mice with High Grade Glioma Undergoing Unrestricted Ketogenic Diet

Author

Ambra Rizzo, Maria Grazia Bruzzone, Emilio Ciusani, Serena Pellegatta, Andrea Salmaggi, Francesco Padelli, Vita Girgenti, Laura Fariselli, and Chiara Vasco

Subjects
0301 basic medicine, Oncology, In vivo magnetic resonance spectroscopy, Cancer Research, medicine.medical_specialty, Magnetic Resonance Spectroscopy, medicine.medical_treatment, Brain tumor, Medicine (miscellaneous), Mice, 03 medical and health sciences, 0302 clinical medicine, Text mining, Internal medicine, medicine, Animals, Multimodal treatment, High-Grade Glioma, 030109 nutrition & dietetics, Nutrition and Dietetics, Brain Neoplasms, business.industry, Glioma, medicine.disease, nervous system diseases, 030220 oncology & carcinogenesis, Diet, Ketogenic, Glioblastoma, business, Ketogenic diet
Abstract

Glioblastoma multiforme (GBM) is considered the most malignant form of primary brain tumor. Despite multimodal treatment, prognosis remains poor. Ketogenic diet (KD) has been suggested for the treatment of GBM. In this study, the syngenic, orthotopic GL261 mouse glioma model was used to evaluate the effects of KD on the metabolic responses of the tumor using 7T magnetic resonance imaging/spectroscopy. GL261 cells were injected into the caudate nucleus of mice. Following implantation, animals were fed with standard chow or underwent a KD. 18 days after initiating the diet, mice fed with KD displayed significantly higher plasmatic levels of ketone bodies and survived longer than those fed with the standard diet. Decreased concentrations of gamma-aminobutyric acid, N-Acetyl-Aspartate and N-acetylaspartylglutamate were found in tumor tissue after 9 days into the KD, while a huge increase in beta-hydroxybutyrate (bHB) was detected in tumor tissue as compared to normal brain. The accumulation of bHB in the tumor tissue in mice undergoing the KD, may suggest either elevated uptake/release of bHB by tumor cells, or the inability of tumor cells in this context to use it for mitochondrial metabolism.

Published
2020

110. A single-centre experience of intravenous thrombolysis for stroke in COVID-19 patients

Author

Davide Sangalli, Chiara Scaccabarozzi, Vittorio Mantero, Daniele Colombo, Marco Filizzolo, Valeria Polonia, and Andrea Salmaggi

Subjects
Male, medicine.medical_specialty, Neurology, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Pneumonia, Viral, Clinical Neurology, Dermatology, Tissue plasminogen activator, Intravenous thrombolysis, Brain Ischemia, Brain ischemia, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, rt-PA, Thrombolytic Therapy, 030212 general & internal medicine, Pandemics, Stroke, Aged, Neuroradiology, SARS-CoV-2, business.industry, COVID-19, General Medicine, Thrombolysis, Middle Aged, medicine.disease, Recombinant Proteins, Psychiatry and Mental health, Tissue Plasminogen Activator, Emergency medicine, Administration, Intravenous, Female, Neurology (clinical), Neurosurgery, Coronavirus Infections, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

The sudden worldwide outbreak of Coronavirus Disease 2019 (COVID-19) has certainly provided new challenges in the management of acute ischaemic stroke, and the risk-benefit ratio of intravenous thrombolysis in COVID-19 positive patients is not well known. We describe four COVID-19 patients treated with intravenous thrombolysis for acute ischaemic stroke. Although rt-PA administration is the main therapeutic strategy, our patients experienced unpredictable complications and showed atypical features: the overall mortality was very high. In conclusion, in this article, we provide information about these cases and discuss the possible explanation behind this trend.

Published
2020

111. Carotid artery stenting during endovascular thrombectomy for acute ischemic stroke with tandem occlusion: the Italian Registry of Endovascular Treatment in Acute Stroke

Author

Sallustio, Fabrizio, Pracucci, Giovanni, Cappellari, Manuel, Saia, Valentina, Mascolo, Alfredo Paolo, Marrama, Federico, Gandini, Roberto, Koch, Giacomo, Diomedi, Marina, D’Agostino, Federica, Rocco, Alessandro, Da Ros, Valerio, Wlderk, Andrea, Nezzo, Marco, Argirò, Renato, Morosetti, Daniele, Renieri, Leonardo, Nencini, Patrizia, Vallone, Stefano, Zini, Andrea, Bigliardi, Guido, Pitrone, Antonio, Grillo, Francesco, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Simonetti, Luigi, Haznedari, Nicolò, Paolucci, Matteo, Mavilio, Nicola, Malfatto, Laura, Menozzi, Roberto, Genovese, Antonio, Cosottini, Mirco, Orlandi, Giovanni, Comai, Alessio, Franchini, Enrica, Pedicelli, Alessandro, Frisullo, Giovanni, Puglielli, Edoardo, Casalena, Alfonsina, Cester, Giacomo, Baracchini, Claudio, Castellano, Davide, Di Liberto, Alessandra, Ricciardi, Giuseppe Kenneth, Chiumarulo, Luigi, Petruzzellis, Marco, Lafe, Elvis, Persico, Alessandra, Cavasin, Nicola, Critelli, Adriana, Semeraro, Vittorio, Tinelli, Angelica, Giorgianni, Andrea, Carimati, Federico, Auteri, William, Rizzuto, Stefano, Biraschi, Francesco, Nicolini, Ettore, Ferrari, Antonio, Melis, Maurizio, Calia, Stefano, Tassinari, Tiziana, Nuzzi, Nunzio Paolo, Corato, Manuel, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Gallesio, Ivan, Ruiz, Luigi, Dui, Giovanni, Carboni, Nicola, Amistà, Pietro, Russo, Monia, Maiore, Mario, Zanda, Bastianina, Craparo, Giuseppe, Mannino, Marina, Inzitari, Domenico, Toni, Danilo, Mangiafico, Salvatore, Gasparotti, R., Inzitari, D., Mangiafico, S., Toni, D., Vallone, S., Zini, A., Bergui, M., Causin, F., Ciccone, A., Nencini, P., Saletti, A., Sallustio, F., Tassi, R., Thyrion, F. Zappoli, Pracucci, G., Saia, V., Gandini, R., Da Ros, V., Greco, L., Morosetti, D., Diomedi, M., Nappini, S., Limbucci, N., Renieri, L., Fainardi, E., Verganti, L., Sacchetti, F., Zelent, G., Bigliardi, G., Dell’Acqua, M. L., Picchetto, L., Vandelli, L., Pentore, R., Maffei, S., Nichelli, P., Longo, M., Pitrone, A., Vinci, S. L., Velo, M., Caragliano, A., Tessitore, A., Bonomo, O., Musolino, R., La Spina, P., Casella, C., Fazio, M. C., Grillo, F., Cotroneo, M., Dell’Aera, C., Francalanza, I., Bracco, S., Cioni, S., Gennari, P., Vallone, I. M., Cerase, A., Martini, G., Stura, G., Daniele, D., Cerrato, P., Naldi, A., Onofrio, M., De Vito, A., Azzini, C., Casetta, I., Mardighian, D., Frigerio, M., Magoni, M., Costa, A., Simonetti, L., Cirillo, L., Taglialatela, F., Isceri, S., Princiotta, C., Dall’Olio, M., Cellerini, M., Gentile, M., Piccolo, L., Migliaccio, L., Brancaleoni, L., Naldi, F., Romoli, M., Zaniboni, A., Ruggiero, M., Sanna, A., Haznedari, N., Commodaro, C., Longoni, M., Biguzzi, S., Cordici, F., Malatesta, E., Castellan, L., Mavilio, N., Salsano, G., Malfatto, L., Finocchi, C., Menozzi, R., Piazza, P., Epifani, E., Andreone, A., Scoditti, U., Castellini, P., Latte, L., Grisendi, I., Cosottini, M., Puglioli, M., Lazzarotti, G., Lauretti, D., Mancuso, M., Giannini, N., Maccarone, M., Orlandi, G., Comai, A., Bonatti, G., Nano, G., Ferro, F., Bonatti, M., Dall’Ora, E., Dossi, R. Currò, Turri, E., Turri, M., Colosimo, C., Pedicelli, A., D’Argento, F., Alexandre, A., Frisullo, G., Di Egidio, V., Puglielli, E. G., Ruggero, L., Assetta, M., Casalena, A., Cester, G., Baracchini, C., Viaro, F., Pieroni, A., Vaudano, G., Comelli, C., Di Maggio, L., Castellano, D., Cavallo, R., Duc, E., Chianale, G., Ciceri, E. F. M., Plebani, M., Augelli, R., Zampieri, P., Grazioli, A., Cappellari, M., Forlivesi, S., Tomelleri, G., Micheletti, N., Chiumarulo, L., Zimatore, D. S., Federico, F., Petruzzelli, M., Zappoli, F., Lafe, E., Sanfilippo, G., Sgreccia, A., Martignoni, A., Cavallini, A., Denaro, F., Persico, A., Cagliari, E., Cavasin, N., Quatrale, R., Critelli, A., Burdi, N., Semeraro, V., Lucarelli, N., Ganimede, M. P., Internò, S., Tinelli, A., Prontera, M. P., Pesare, A., Cotroneo, E., Pampana, E., Ricciardi, F., Gigli, R., Pezzella, F. R., Corsi, F., Giorgianni, A., Baruzzi, F., Pellegrino, C., Terrana, A., Versino, M., Delodovici, M. L., Carimati, F., Cariddi, L. Princiotta, Auteri, W., Di Benedetto, O., Silvagni, U., Perrotta, P., Crispino, E., Petrone, A., Stancati, F., Rizzuto, S., Pugliese, P., Pisani, E., Siniscalchi, A., Gaudiano, C., Pirritano, D., Del Giudice, F., Piano, M., Agostoni, E., Motto, C., Gatti, A., Guccione, A., Tortorella, R., Stecco, A., Guzzardi, G., Del Sette, B., Coppo, L., Baldan, J., Romano, D., Siani, A., Locatelli, G., Saponiero, R., Napolitano, R., De Gregorio, M., Volpe, G., Tenuta, M., Guidetti, G., Biraschi, F., Wulbek, A., Falcou, A., Anzini, A., Mancini, A., De Michele, M., Fausti, S., Di Mascio, M. T., Durastanti, L., Sbardella, E., Mellina, V., Nicolini, E., Comelli, S., Ganau, C., Corraine, S., Fusaro, F., Ferrari, A., Schirru, F., Ledda, V., Secci, S., Melis, M., Piras, V., Moller, J., Padolecchia, R., Allegretti, L., Caldiera, V., Calia, S., Ganci, G., Tassinari, T., Sugo, A., De Nicola, M., Giannoni, M., Bruni, S., Gambelli, E., Provinciali, L., Nuzzi, N. P., Marcheselli, S., Corato, M., Scomazzoni, F., Simionato, F., Roveri, L., Filauri, P., Sacco, S., Orlandi, B., De Santis, F., Tiseo, C., Notturno, F., Ornello, R., Pavia, M., Squassina, G., Cobelli, M., Morassi, M., Magni, E., Invernizzi, P., Pepe, F., Bigni, B., Costa, P., Crabbio, M., Griffini, S., Palmerini, F., Piras, M. P., Gallesio, I., Barbero, S., Ferrandi, D., Dui, G., Fancello, M. C., Zedda, S., Ticca, A., Saddi, M. V., Deiana, G., Rossi, R., Carboni, N., Mela, A., Amistà, P., Russo, M., Iannucci, G., Pinna, V., Di Clemente, L., Santi, M., De Boni, A., De Luca, C., Natrella, M., Fanelli, G., Cristoferi, M., Bottacchi, E., Corso, G., Tosi, P., Sessa, M., Giossi, A., Baietti, Null, Romano, G., Meineri, P., Armentano, A., Versace, P., Arcudi, L., Galvano, G., Petralia, B., Feraco, P., Luppi, G., Giometto, B., Bignamini, V., Piffer, S., Meloni, G. B., Fabio, C., Maiore, M., Pintus, F., Pischedda, A., Manca, A., Mongili, C., Zanda, B., Baule, A., Florio, F., Ciccarese, G., Leone, M., Di Viesti, P., Pappalardo, M. P., Craparo, G., Gallo, C., Monaco, S., Mannino, M., Muto, M., Guarnieri, Gl., Andreone, V., Passalacqua, G., Allegritti, M., Caproni, S., Filizzolo, M., Salmaggi, A., Giordano, A., Marini, C., Frattale, I., Lucente, G., Nozzoli, C., and Lupo, F. A.

Subjects
Stent, Acute stroke, Settore MED/37 - Neuroradiologia, Acute stroke Internal carotid artery diseases Stent Thrombectomy, Neurology (clinical), General Medicine, Settore MED/26, Internal carotid artery diseases, Thrombectomy
Abstract

The management of tandem extracranial internal carotid artery and intracranial large vessel occlusion during endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) has been under-investigated. We sought to investigate outcomes of AIS patients with tandem occlusion (TO) treated with carotid artery stenting (CAS) compared to those not treated with CAS (no-CAS) during EVT.We performed a cohort study using data from AIS patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke. Outcomes were 3 months' mortality, functional outcome, complete and successful recanalization, any intracranial hemorrhage, parenchymal hematoma and symptomatic intracerebral hemorrhage.Among 466 AIS patients with TO, CAS patients were 122 and no-CAS patients were 226 (118 excluded). After adjustment for unbalanced variables, CAS was associated with a lower rate of 3 months' mortality (OR 0.407, 95% CI 0.171-0.969, p = 0.042). After adjustment for pre-defined variables, CAS was associated with a lower rate of 3 months' mortality (aOR 0.430, 95% CI 0.187-0.989, p = 0.047) and a higher rate of complete recanalization (aOR 1.986, 95% CI 1.121-3.518, p = 0.019), successful recanalization (aOR 2.433, 95% CI 1.263-4.686, p = 0.008) and parenchymal hematoma (aOR 2.876, 95% CI 1.173-7.050, p = 0.021). CAS was associated with lower 3 months mortality (OR 0.373, 95% CI 0.141-0.982, p = 0.046) and higher rates of successful recanalization (OR 2.082, 95% CI 1.099-3.942, p = 0.024) after adjustment for variables associated with 3 months' mortality and successful recanalization, respectively.Among AIS patients with TO, CAS during EVT was associated with a higher rate of successful reperfusion and a lower rate of 3 months' mortality.

Published
2022

113. Don't forget Allgrove syndrome in adult patients as a bulbar-ALS mimicker.

Author

Vigano', Martina, Mantero, Vittorio, Basilico, Paola, Pirro, Fiammetta, Ronchi, Dario, Di Fonzo, Alessio, and Salmaggi, Andrea

Subjects
AMYOTROPHIC lateral sclerosis, MOTOR neuron diseases, GENETIC disorders, SYNDROMES, GENETIC disorder diagnosis, ESOPHAGEAL achalasia, ADRENAL tumors
Abstract

Introduction: Allgrove syndrome is a genetic disorder characterized by a multisystem involvement manifesting mainly in childhood with esophageal achalasia, adrenal insufficiency, and alacrima. Associated neurological manifestations are frequent in patients with late-onset forms and include peripheral, central, and autonomic dysfunction. The definitive diagnosis remains genetic, but neurological symptoms/signs could be a relevant clue for the diagnosis. Discussion: This syndrome is rare, but it is not impossible for it to occur in adults, so all neurologists must be alert. Moreover, in this regard, neurological symptoms can sometimes be very similar to those of motor neuron disease patients, so that, although rare, Allgrove syndrome may also enter into the differential diagnosis with the bulbar variant of amyotrophic lateral sclerosis. Nevertheless, attention to extra-neurological symptoms must remain high as these play an equally important role in reaching the diagnosis. Case Report: Here we present the case of a patient with some peculiarities that are onset at an advanced age, genetic confirmation of the diagnosis, and prominent neurological involvement, which also opens the differential diagnosis to amyotrophic lateral sclerosis. [ABSTRACT FROM AUTHOR]

Published
2023
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115. Posterior reversible encephalopathy syndrome and COVID-19: A series of 6 cases from Lombardy, Italy

Author

Filippo Martinelli Boneschi, Andrea Giorgianni, Sandro Beretta, Federico Carimati, Diego Spagnoli, Maurizio Versino, Stefania Rota, Payam Tabaee Damavandi, Antonio Tetto, Nereo Bresolin, Antonio Colombo, Lorenzo Lorusso, Maria Di Stefano, Paola Melzi, Massimo Ferrarini, Giulia Nastasi, Mattia Pozzato, Paola Banfi, Marco Mauri, Maria Repaci, Margherita Canesi, Gabriele Vinacci, Alessandro Clemenzi, Lucia Princiotta Cariddi, Margherita Marelli, Andrea Salmaggi, Davide Vallauri, Colombo, A, Martinelli Boneschi, F, Beretta, S, Bresolin, N, Versino, M, Lorusso, L, Spagnoli, D, Nastasi, G, Vallauri, D, Rota, S, Repaci, M, Ferrarini, M, Pozzato, M, Princiotta Cariddi, L, Tabaee Damavandi, P, Carimati, F, Banfi, P, Clemenzi, A, Marelli, M, Giorgianni, A, Vinacci, G, Mauri, M, Melzi, P, Di Stefano, M, Tetto, A, Canesi, M, and Salmaggi, A

Subjects
Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Encephalopathy, Assisted ventilation, lcsh:RC346-429, PRES, 03 medical and health sciences, 0302 clinical medicine, Seizures, Intensive care, medicine, In patient, 030212 general & internal medicine, COVID-19, lcsh:Neurology. Diseases of the nervous system, Genome search, business.industry, Posterior reversible encephalopathy syndrome, medicine.disease, Seizure, Neurology, Original Article, business, 030217 neurology & neurosurgery
Abstract

Posterior reversible encephalopathy cases are increasingly being reported in patients affected by COVID-19, but the largest series so far only includes 4 patients. We present a series of 6 patients diagnosed with PRES during COVID-19 hospitalized in 5 Centers in Lombardia, Italy. 5 out of the 6 patients required intensive care assistence and seizures developed at weaning from assisted ventilation. 3 out of 6 patients underwent cerebrospinal fluid analysis which was normal in all cases, with negative PCR for Sars-CoV-2 genome search. PRES occurrence may be less rare than supposed in COVID-19 patients and a high suspicion index is warranted for prompt diagnosis and treatment., Highlights • Posterior reversible encephalopathy syndrome is increasingly being reported in COVID-19 patients. • Weaning from assisted ventilation may be a critical moment in seizure development. • No evidence of viral genome in the cerebrospinal fluid in this cohort

Published
2021

116. SARS-CoV-2 infection and acute ischemic stroke in Lombardy, Italy

Author

Matteo Cortinovis, Elisa Raimondi, Federico Pozzi, Alessandro Padovani, Laura Fusi, Federico Carimati, Sonia Bonacina, Mario Grassi, Valentina Mazzoleni, Alessandro Prelle, Anna Magherini, Simonetta Gerevini, Andrea Pilotto, Manuel Corato, Valeria De Giuli, Enrico Premi, Valentina Puglisi, Giorgio Silvestrelli, Francesco Santangelo, Alessia Giossi, Davide Sangalli, Maurizio Versino, Simone Beretta, Giuditta Giussani, Francesca Barbieri, Giampiero Grampa, Rubjona Xhani, Susanna Diamanti, Daria Valeria Roccatagliata, Alfonso Ciccone, Stefano Masciocchi, Elio Agostoni, Nicola Rifino, Massimo Gamba, Maria Sessa, Anna Cavallini, Sara La Gioia, Alberto Benussi, Bruno Censori, Martina Locatelli, Alessandro Pezzini, Andrea Salmaggi, Fernando Palluzzi, Mauro Magoni, Luisa Vinciguerra, Debora Pezzini, Simona Marcheselli, Carlo Ferrarese, Pezzini, A, Grassi, M, Silvestrelli, G, Locatelli, M, Rifino, N, Beretta, S, Gamba, M, Raimondi, E, Giussani, G, Carimati, F, Sangalli, D, Corato, M, Gerevini, S, Masciocchi, S, Cortinovis, M, La Gioia, S, Barbieri, F, Mazzoleni, V, Pezzini, D, Bonacina, S, Pilotto, A, Benussi, A, Magoni, M, Premi, E, Prelle, A, Agostoni, E, Palluzzi, F, De Giuli, V, Magherini, A, Roccatagliata, D, Vinciguerra, L, Puglisi, V, Fusi, L, Diamanti, S, Santangelo, F, Xhani, R, Pozzi, F, Grampa, G, Versino, M, Salmaggi, A, Marcheselli, S, Cavallini, A, Giossi, A, Censori, B, Ferrarese, C, Ciccone, A, Sessa, M, and Padovani, A

Subjects
Male, Percentile, medicine.medical_specialty, Logistic regression, Brain Ischemia, Internal medicine, medicine, Humans, Hospital Mortality, Risk factor, Stroke, Survival analysis, Ischemic Stroke, Retrospective Studies, Original Communication, SARS-CoV-2, business.industry, Mortality rate, COVID-19, Atrial fibrillation, medicine.disease, Italy, Neurology, Risk factors, Viral infection, Etiology, Neurology (clinical), business
Abstract

Objective To characterize patients with acute ischemic stroke related to SARS-CoV-2 infection and assess the classification performance of clinical and laboratory parameters in predicting in-hospital outcome of these patients. Methods In the setting of the STROKOVID study including patients with acute ischemic stroke consecutively admitted to the ten hub hospitals in Lombardy, Italy, between March 8 and April 30, 2020, we compared clinical features of patients with confirmed infection and non-infected patients by logistic regression models and survival analysis. Then, we trained and tested a random forest (RF) binary classifier for the prediction of in-hospital death among patients with COVID-19. Results Among 1013 patients, 160 (15.8%) had SARS-CoV-2 infection. Male sex (OR 1.53; 95% CI 1.06–2.27) and atrial fibrillation (OR 1.60; 95% CI 1.05–2.43) were independently associated with COVID-19 status. Patients with COVID-19 had increased stroke severity at admission [median NIHSS score, 9 (25th to75th percentile, 13) vs 6 (25th to75th percentile, 9)] and increased risk of in-hospital death (38.1% deaths vs 7.2%; HR 3.30; 95% CI 2.17–5.02). The RF model based on six clinical and laboratory parameters exhibited high cross-validated classification accuracy (0.86) and precision (0.87), good recall (0.72) and F1-score (0.79) in predicting in-hospital death. Conclusions Ischemic strokes in COVID-19 patients have distinctive risk factor profile and etiology, increased clinical severity and higher in-hospital mortality rate compared to non-COVID-19 patients. A simple model based on clinical and routine laboratory parameters may be useful in identifying ischemic stroke patients with SARS-CoV-2 infection who are unlikely to survive the acute phase.

Published
2021

118. Multiple sclerosis and COVID‐19: How could therapeutic scenarios change during the pandemic?

Author

Lucia Abate, Vittorio Mantero, Andrea Salmaggi, and Christian Cordano

Subjects
2019-20 coronavirus outbreak, Multiple Sclerosis, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), education, coronavirus, Reviews, Review, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Virology, Pandemic, medicine, Humans, 030212 general & internal medicine, Pandemics, Coronavirus, SARS-CoV-2, business.industry, Multiple sclerosis, nervous system, COVID-19, medicine.disease, immune system, Infectious Diseases, Pharmaceutical Preparations, 030211 gastroenterology & hepatology, business
Abstract

Recent evidence suggested that neurological manifestations occur in patients with a severe form of coronavirus disease (COVID‐19). On the basis of this issue, neurologists are very concerned about patients with neurological disorders, especially multiple sclerosis (MS), as consumers of immunosuppressive or immune‐modulating drugs. Therefore, the administration of proper disease‐modifying therapies (DMTs) in MS patients is critical during the pandemic status. On the one hand, both the autoimmune diseases and immunosuppressive drugs increase the risk of infection due to impairment in the immune system, and on the other hand, postponing of MS treatment has serious consequences on the central nervous system. In the present study, we discussed recent literature about the effect of DMTs administration on the severity of COVID‐19 in the MS patients. Overall, it seems that DMTs do not provoke the COVID‐19 infection in the MS patients by declining immune responses and cytokine storm. However, as a precaution, the supervision of a neurologist is highly recommended., Highlights Neurological manifestations occur in patients with severe form of coronavirus infection.Administration of proper disease‐modifying therapies (DMTs) in MS patients is critical during pandemic status.It seems that administration of DMTs do not provoke the COVID‐19 infection in the MS patients.

Published
2021

123. Covid-19-associated Guillain-Barré syndrome in the first wave of COVID-19 pandemic in Lombardia: Increased incidence or increased seroprevalence?

Author

Boneschi, Filippo Martinelli, Colombo, Antonio, Bresolin, Nereo, Sessa, Maria, Pozzato, Mattia, Grampa, Giampiero, Bassi, Pietro, Magni, Eugenio, Versino, Maurizio, Ferrarese, Carlo, Zarcone, Davide, Albanese, Alberto, Micieli, Giuseppe, Zanferrari, Carla, Cagnana, Antonio, Ferrante, Claudio, Zilioli, Angelo, Locatelli, Davide, Calloni, Maria, Delodovici, Maria Luisa, Foresti, Camillo, Frigeni, Barbara, Canella, Stefania, Xhani, Rubjona, Crabbio, Massimo, Clemenzi, Alessandro, Mauri, Marco, Beretta, Simone, La Spina, Isidoro, Bernasconi, Simona, Cavallini, Anna, Ranieri, Michela, D'Adda, Elisabetta, Fruguglietti, Maria Elisa, Peverelli, Lorenzo, Agosti, Edoardo, Rigamonti, Andrea, and Salmaggi, Andrea

Published
2021
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124. Clinical, neurophysiological and neuroradiological characteristics of 30 cases of SARS-COV-2-associated encephalitis in Lombardia

Author

Boneschi, Filippo Martinelli, Sessa, Maria, Guidetti, Donata, Grampa, Giampiero, Magni, Eugenio, Versino, Maurizio, Ferrarese, Carlo, Zarcone, Davide, Prelle, Alessandro, Micieli, Giuseppe, Zanferrari, Carla, Frediani, Fabio, Cagnana, Antonio, Zilioli, Angelo, Calloni, Maria, Mariani, Emilio, Foresti, Camillo, Crabbio, Massimo, La Spina, Isidoro, Maschio, Vera Pacoova Dal, Giorgetti, Andrea, Cavallini, Anna, Ranieri, Michela, D'Adda, Elisabetta, Salmaggi, Andrea, and Colombo, Antonio

Published
2021
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128. Contributors

Author

Avanzini, Giuliano, primary, Cotterman-Hart, Sheri, additional, de Curtis, Marco, additional, Deogaonkar, Milind, additional, Dinapoli, Loredana, additional, Granata, Tiziana, additional, Moore, J. Layne, additional, Librizzi, Laura, additional, Lopez, Jonathan, additional, Maschio, Marta, additional, Mindel, Jesse W., additional, Newton, Herbert B., additional, Otero, Jose J., additional, Paladin, Francesco, additional, Ray, Leslie, additional, Rezai, Ali, additional, Rigamonti, Andrea, additional, Salmaggi, Andrea, additional, and Shaikhouni, Ammar, additional

Published
2015
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130. Lack of development of Pneumocystis jirovecii Pneumonia in a cohort of 103 Italian glioblastoma patients not receiving prophylaxis during post-surgical chemoradiotherapy

Author

Rifino, N, Rigamonti, A, Guida, F, De Nobili, G, Spena, G, Ferrarese, C, Salmaggi, A, Rifino N., Rigamonti A., Guida F. M., De Nobili G., Spena G., Ferrarese C., Salmaggi A., Rifino, N, Rigamonti, A, Guida, F, De Nobili, G, Spena, G, Ferrarese, C, Salmaggi, A, Rifino N., Rigamonti A., Guida F. M., De Nobili G., Spena G., Ferrarese C., and Salmaggi A.

Published
2019

131. Multicenter, single arm, phase II trial on the efficacy of ortataxel in recurrent glioblastoma

Author

Silvani, A, De Simone, I, Fregoni, V, Biagioli, E, Marchioni, E, Caroli, M, Salmaggi, A, Pace, A, Torri, V, Gaviani, P, Quaquarini, E, Simonetti, G, Rulli, E, D'Incalci, M, Poli, D, Mariotti, E, Caramia, G, Gritti, A, Pacchetti, I, Zucchetti, M, Lanza, A, Basso, G, Bini, P, Berzero, G, Diamanti, L, Di Cristofori, A, Manzoni, A, Lanfranchi, G, Ardizzoia, A, Villani, V, Silvani A., De Simone I., Fregoni V., Biagioli E., Marchioni E., Caroli M., Salmaggi A., Pace A., Torri V., Gaviani P., Quaquarini E., Simonetti G., Rulli E., D'Incalci M., Poli D., Mariotti E., Caramia G., Gritti A. P., Pacchetti I., Zucchetti M., Lanza A., Basso G., Bini P., Berzero G., Diamanti L., Di Cristofori A., Manzoni A., Lanfranchi G., Ardizzoia A., Villani V., Silvani, A, De Simone, I, Fregoni, V, Biagioli, E, Marchioni, E, Caroli, M, Salmaggi, A, Pace, A, Torri, V, Gaviani, P, Quaquarini, E, Simonetti, G, Rulli, E, D'Incalci, M, Poli, D, Mariotti, E, Caramia, G, Gritti, A, Pacchetti, I, Zucchetti, M, Lanza, A, Basso, G, Bini, P, Berzero, G, Diamanti, L, Di Cristofori, A, Manzoni, A, Lanfranchi, G, Ardizzoia, A, Villani, V, Silvani A., De Simone I., Fregoni V., Biagioli E., Marchioni E., Caroli M., Salmaggi A., Pace A., Torri V., Gaviani P., Quaquarini E., Simonetti G., Rulli E., D'Incalci M., Poli D., Mariotti E., Caramia G., Gritti A. P., Pacchetti I., Zucchetti M., Lanza A., Basso G., Bini P., Berzero G., Diamanti L., Di Cristofori A., Manzoni A., Lanfranchi G., Ardizzoia A., and Villani V.

Abstract

Background and purpose: Glioblastoma (GBM) is the most aggressive and frequent subtype of all malignant gliomas. At the time of recurrence, therapeutic options are lacking. Ortataxel, a second-generation taxane was reported to be effective in pre-clinical and phase I clinical studies. The aim of this study was to evaluate a potential therapeutic activity of ortataxel in patients with GBM recurring after surgery and first line treatment. Methods: In this phase II study, according to a two stage design, adult patients with histologically confirmed GBM in recurrence after surgery or biopsy, standard radiotherapy and chemotherapy with temozolomide were considered eligible. Patients included were treated with ortataxel 75 mg/m2 i.v. every 3 weeks until disease progression. The primary objective of the study was to evaluate the activity of ortataxel in terms of progression free survival (PFS) at 6 months after the enrollment. PFS, overall survival at 9 months after the enrollment, objective response rate, compliance and safety were evaluated as secondary endpoints. Results: Between Nov 26, 2013 and Dec 12, 2015, 40 patients were recruited across six centres. The number of patients alive and free from progression at 6 months after the enrollment, observed in the first stage was four (11.4%), out of 35 patients included in the analysis, below the minimum number of events (7 out of 33) required to continue the study with the second stage The most important toxicities were neutropenia and hepatotoxicity that occurred in 13.2% of patients and leukopenia that occurred in 15.8% of patients. Conclusion: Overall ortataxel treatment fail to demonstrate a significant activity in recurrent GBM patients. However in a limited number of patients the drug produced a benefit that lasted for a long time. Trial registration: This study is registered with ClinicalTrials.gov, number NCT01989884

Published
2019

133. Adult brainstem glioma: a multicentre retrospective analysis of 47 Italian patients

Author

Giorgia Simonetti, Andrea Salmaggi, Giulia Berzero, Roberta Rudà, R. Merli, Federica Franchino, Antonio Silvani, Ivano Chiarotti, Andrea Pace, Giannantonio Spena, Maura Servida, Alfonso Cerase, Veronica Villani, Andrea Rigamonti, Alberto Picca, Rigamonti, A., Simonetti, G., Silvani, A., Ruda, R., Franchino, F., Villani, V., Pace, A., Merli, R., Servida, M., Picca, A., Berzero, G., Cerase, A., Chiarotti, I., Spena, G., and Salmaggi, A.

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Survival, Dermatology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Glioma, Biopsy, medicine, Brain Stem Neoplasms, Humans, 030212 general & internal medicine, Neuroradiology, Retrospective Studies, Univariate analysis, Performance status, medicine.diagnostic_test, business.industry, Brain Neoplasms, Retrospective cohort study, General Medicine, medicine.disease, Prognosis, Management, Brainstem gliomas, Clinical trial, Psychiatry and Mental health, Italy, Female, Neurology (clinical), Neurosurgery, business, 030217 neurology & neurosurgery
Abstract

Background and purpose: Adult brainstem gliomas are rare primary brain tumours with heterogeneous clinical course. The low frequency of these tumours makes it difficult to achieve high-quality evidence regarding prognostic factors, adequate therapeutic approach and outcome in such patients. Methods: In this retrospective study, we analysed clinical, radiological, molecular, prognostic and therapeutic factors in a series of 47 histologically proven adult brainstem gliomas recruited over a 20-year period (1998–2018). Results: Twenty-two patients were male, 25 female with median age of 39 years. The tumour involved one brainstem segment in 20 cases and 2 or more segments in 27. Contrast enhancement was reported in 28 cases. Surgical procedures included biopsy in 26 cases and partial/total resection in the remaining 21. Histological diagnosis was of low-grade glioma in 23 patients, high-grade glioma in 22 and non-diagnostic in 2 cases. Data regarding molecular biology were available for 22 patients. Median overall survival was 35 months, in particular 16 months in high-grade glioma and 84 months in low-grade glioma. At univariate analysis, tumour grade was the only factor with a statistically significant impact on survival time (p = 0,003), whereas younger age, better performance status and total/subtotal resection showed a trend to more prolonged survival. This study also confirms safety of biopsy/surgery in adult brainstem glioma patients and shows a clear trend to a more frequent assessment of molecular biology data. Conclusions: Further prospective multicentre efforts, and hopefully clinical trials, are necessary to improve outcome in this neglected glioma patient population.

Published
2020

134. CLEARANCE OF BETA-AMYLOID OLIGOMERS BY PERIPHERAL MONOCYTES: FURTHER OBSERVATIONS REGARDING THE MODULATORY ROLE OF DONEPEZIL

Author

A. Karantzoulis, E. Conti, M. Slongo, V. Rodriguez-Menendez, M. Mauri, F. Da Re, A. Aliprandi, P. Basilico, A. Salmaggi, I. Appollonio, C. Ferrarese, L. Tremolizzo, Karantzoulis, A, Conti, E, Slongo, M, Rodriguez-Menendez, V, Mauri, M, Da Re, F, Aliprandi, A, Basilico, P, Salmaggi, A, Appollonio, I, Ferrarese, C, and Tremolizzo, L

Subjects
MED/26 - NEUROLOGIA, Donepezil, phagocytosis, beta-amyloid
Published
2020

135. ALS Cognitive Behavioral Screen (ALS-CBS): normative values for the Italian population and clinical usability

Author

Tremolizzo, L., Lizio, A., Santangelo, G., Diamanti, S., Lunetta, C., Gerardi, F., Messina, S., La Foresta, S., Riva, N., Falzone, Y., Filippi, M., Woolley, S. C., Sansone, V. A., Siciliano, M., Ferrarese, C., Appollonio, I., Aliprandi, A., Cereda, D., Conti, E., Gallone, A. M., Mantero, V., Marzorati, L., Mosca, L., Pellegrini, A., Perini, M., Rigamonti, A., Sala, G., Salmaggi, A., Spinazzola, L., Susani, E., Tarlarini, C., Trojsi, F., Zarcone, D., Tremolizzo, L., Lizio, A., Santangelo, G., Diamanti, S., Lunetta, C., Gerardi, F., Messina, S., La Foresta, S., Riva, N., Falzone, Y., Filippi, M., Woolley, S. C., Sansone, V. A., Siciliano, M., Ferrarese, C., Appollonio, I., Aliprandi, A., Cereda, D., Conti, E., Gallone, A. M., Mantero, V., Marzorati, L., Mosca, L., Pellegrini, A., Perini, M., Rigamonti, A., Sala, G., Salmaggi, A., Spinazzola, L., Susani, E., Tarlarini, C., Trojsi, F., Zarcone, D., Tremolizzo, L, Lizio, A, Santangelo, G, Diamanti, S, Lunetta, C, Gerardi, F, Messina, S, La Foresta, S, Riva, N, Falzone, Y, Filippi, M, Woolley, S, Sansone, V, Siciliano, M, Ferrarese, C, Appollonio, I, and Sala, G

Subjects
Adult, Male, medicine.medical_specialty, Neurology, Cognitive, Italian, Normative, Screening test, Dermatology, Disease, Behavioral Symptoms, Neuropsychological Tests, M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Reference Values, medicine, 80 and over, Humans, Cognitive Dysfunction, 030212 general & internal medicine, Amyotrophic lateral sclerosis, Aged, MED/26 - NEUROLOGIA, Aged, 80 and over, business.industry, Amyotrophic Lateral Sclerosis, Cognition, Usability, General Medicine, Caregiver burden, Middle Aged, medicine.disease, Test (assessment), Psychiatry and Mental health, M-PSI/03 - PSICOMETRIA, Italy, ALS, ALS-CBS, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, Clinical psychology
Abstract

Amyotrophic lateral sclerosis (ALS) patients often express cognitive and behavioral dysfunctions within the so-called “frontotemporal spectrum disorders.” Guidelines recommend screening of such dysfunctions, albeit only ALS dedicated tools are eventually suitable, due to the profound motor limitations induced by the disease. ALS Cognitive Behavioral Screen (ALS-CBS) is such a screening tool but normative data are not available, limiting its widespread implementation. Our aim consisted in producing normative data for the Italian version of the ALS-CBS. The scale was administered to n = 458 healthy controls with different age and education. Following translation and back translation of the original version of the test, normative data and correction scores for the ALS-CBS cognitive subtest (ALS-CBSci) were generated. Furthermore, n = 100 ALS consecutive outpatients with a wide range of cognitive and motor severity underwent to the ALS-CBS, besides FAB and Weigl sorting test (WST), in order to check its usability. Completion rate was 100% for ALS-CBS and WST, and 68% for the FAB. Corrected ALS-CBS scores showed 12% detection rate of significant cognitive dysfunction with a moderate kappa with FAB and WST. For the ALS-CBS behavioral subtest (ALS-CBSbi), a caregiver was available for n = 81 ALS patients and asked to complete the subset. The detection rate for behavioral dysfunction was 55.5%, and a mild correlation between with the Caregiver Burden Inventory was present (r = − 0.26, p = 0.04). In conclusion, we offer here normative data for the ALS-CBS, a handy tool for screening frontotemporal spectrum dysfunctions in ALS patients, and confirm its usability and validity in an outpatient setting.

Published
2020

136. Impact of SARS-CoV-2 infection on acute intracerebral haemorrhage in northern Italy

Author

Sangalli, Davide, Martinelli-Boneschi, Filippo, Versino, Maurizio, Colombo, Irene, Ciccone, Alfonso, Beretta, Simone, Marcheselli, Simona, Altavilla, Riccardo, Roncoroni, Mauro, Beretta, Sandro, Lorusso, Lorenzo, Cavallini, Anna, Prelle, Alessandro, Guidetti, Donata, La Gioia, Sara, Santalucia, Paola, Zanferrari, Carla, Grampa, Giampiero, D'Adda, Elisabetta, Peverelli, Lorenzo, Colombo, Antonio, and Salmaggi, Andrea

Published
2021
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140. Multicenter, single arm, phase II trial on the efficacy of ortataxel in recurrent glioblastoma

Author

Silvani A., De Simone I., Fregoni V., Biagioli E., Marchioni E., Caroli M., Salmaggi A., Pace A., Torri V., Gaviani P., Quaquarini E., Simonetti G., Rulli E., D'Incalci M., Poli D., Mariotti E., Caramia G., Gritti A. P., Pacchetti I., Zucchetti M., Lanza A., Basso G., Bini P., Berzero G., Diamanti L., Di Cristofori A., Manzoni A., Lanfranchi G., Ardizzoia A., Villani V., Silvani, A., De Simone, I., Fregoni, V., Biagioli, E., Marchioni, E., Caroli, M., Salmaggi, A., Pace, A., Torri, V., Gaviani, P., Quaquarini, E., Simonetti, G., Rulli, E., D'Incalci, M., Poli, D., Mariotti, E., Caramia, G., Gritti, A. P., Pacchetti, I., Zucchetti, M., Lanza, A., Basso, G., Bini, P., Berzero, G., Diamanti, L., Di Cristofori, A., Manzoni, A., Lanfranchi, G., Ardizzoia, A., Villani, V., Silvani, A, De Simone, I, Fregoni, V, Biagioli, E, Marchioni, E, Caroli, M, Salmaggi, A, Pace, A, Torri, V, Gaviani, P, Quaquarini, E, Simonetti, G, Rulli, E, D'Incalci, M, Poli, D, Mariotti, E, Caramia, G, Gritti, A, Pacchetti, I, Zucchetti, M, Lanza, A, Basso, G, Bini, P, Berzero, G, Diamanti, L, Di Cristofori, A, Manzoni, A, Lanfranchi, G, Ardizzoia, A, and Villani, V

Subjects
Oncology, Male, Cancer Research, medicine.medical_treatment, Phases of clinical research, Antineoplastic Agent, 0302 clinical medicine, Recurrence, Stage (cooking), Leukopenia, Brain Neoplasms, Middle Aged, Prognosis, Survival Rate, Bridged-Ring Compound, Neurology, 030220 oncology & carcinogenesis, Ortataxel, Female, Taxoids, medicine.symptom, Human, medicine.drug, Adult, Bridged-Ring Compounds, medicine.medical_specialty, Prognosi, Antineoplastic Agents, Taxane, Neutropenia, Follow-Up Studie, Brain Neoplasm, 03 medical and health sciences, Internal medicine, medicine, Humans, Progression-free survival, Survival rate, Aged, Chemotherapy, Temozolomide, business.industry, medicine.disease, Neurology (clinical), Neoplasm Recurrence, Local, business, Glioblastoma, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Background and purpose: Glioblastoma (GBM) is the most aggressive and frequent subtype of all malignant gliomas. At the time of recurrence, therapeutic options are lacking. Ortataxel, a second-generation taxane was reported to be effective in pre-clinical and phase I clinical studies. The aim of this study was to evaluate a potential therapeutic activity of ortataxel in patients with GBM recurring after surgery and first line treatment. Methods: In this phase II study, according to a two stage design, adult patients with histologically confirmed GBM in recurrence after surgery or biopsy, standard radiotherapy and chemotherapy with temozolomide were considered eligible. Patients included were treated with ortataxel 75mg/m2 i.v. every 3weeks until disease progression. The primary objective of the study was to evaluate the activity of ortataxel in terms of progression free survival (PFS) at 6months after the enrollment. PFS, overall survival at 9months after the enrollment, objective response rate, compliance and safety were evaluated as secondary endpoints. Results: Between Nov 26, 2013 and Dec 12, 2015, 40 patients were recruited across six centres. The number of patients alive and free from progression at 6months after the enrollment, observed in the first stage was four (11.4%), out of 35 patients included in the analysis, below the minimum number of events (7 out of 33) required to continue the study with the second stage The most important toxicities were neutropenia and hepatotoxicity that occurred in 13.2% of patients and leukopenia that occurred in 15.8% of patients. Conclusion: Overall ortataxel treatment fail to demonstrate a significant activity in recurrent GBM patients. However in a limited number of patients the drug produced a benefit that lasted for a long time. Trial registration: This study is registered with ClinicalTrials.gov, number NCT01989884.

Published
2018

141. NIHSS as predictor of clinical outcome at 6 months in patients with intracerebral hemorrhage

Author

Cristina Russo, Davide Sangalli, Vittorio Mantero, Andrea Salmaggi, Marco Filizzolo, Nadia Bolognini, Nicola Rifino, Angelo Aliprandi, Chiara Scaccabarozzi, Mantero, V, Scaccabarozzi, C, Aliprandi, A, Sangalli, D, Rifino, N, Filizzolo, M, Russo, C, Bolognini, N, and Salmaggi, A

Subjects
Intracerebral hemorrhage, medicine.medical_specialty, Neurology, business.industry, MEDLINE, Dermatology, General Medicine, medicine.disease, Outcome (game theory), United States, Stroke, Psychiatry and Mental health, Text mining, National Institutes of Health (U.S.), Emergency medicine, medicine, Humans, stroke, intracerebral hemorrhage, National Institutes of Health Stroke Scale, Neurology (clinical), Neurosurgery, business, Cerebral Hemorrhage, Neuroradiology
Published
2019

142. Is It Worth Considering Multicentric High-Grade Glioma a Surgical Disease? Analysis of Our Clinical Experience and Literature Review

Author

Guerrini, Francesco, primary, Mazzeo, Lucio Aniello, additional, Rossi, Giorgio, additional, Verlotta, Mariarosaria, additional, Del Maestro, Mattia, additional, Rampini, Angela Dele, additional, Pesce, Alessandro, additional, Viganò, Marco, additional, Luzzi, Sabino, additional, Galzio, Renato Juan, additional, Salmaggi, Andrea, additional, and Spena, Giannantonio, additional

Published
2021
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143. P14.72 Involving patients and caregivers in the production of guidelines for palliative care in primary brain tumours: identification of intervention priorities

Author

Pace, A, primary, Solari, A, additional, De Panfilis, L, additional, Lissoni, B, additional, Pronello, E, additional, Rudà, R, additional, Silvani, A, additional, Salmaggi, A, additional, Merli, R, additional, De Paula, U, additional, Bertocchi, E, additional, Verza, M, additional, and Veronese, S, additional

Published
2021
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144. COVID‐19 in dimethyl fumarate‐treated patients with multiple sclerosis

Author

Paola Basilico, Lucia Abate, Andrea Salmaggi, Bardia Nourbakhsh, Vittorio Mantero, Roberto Balgera, and Christian Cordano

Subjects
2019-20 coronavirus outbreak, medicine.medical_specialty, Neurology, Multiple Sclerosis, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Dimethyl Fumarate, Clinical Neurology, Letter to the Editors, chemistry.chemical_compound, Multiple Sclerosis, Relapsing-Remitting, medicine, Humans, Neuroradiology, Dimethyl fumarate, business.industry, SARS-CoV-2, Multiple sclerosis, COVID-19, medicine.disease, Virology, chemistry, Neurology (clinical), business, Immunosuppressive Agents
Published
2020

145. Sunitinib associated posterior reversible encephalopathy syndrome in a patient treated for GIST

Author

Nicola Rifino, Andrea Salmaggi, Paola Basilico, Chiara Scaccabarozzi, Vittorio Mantero, Jessica Arnoffi, and Marco Filizzolo

Subjects
medicine.medical_specialty, Neurology, GiST, business.industry, Sunitinib, Posterior reversible encephalopathy syndrome, General Medicine, medicine.disease, medicine, Neurology (clinical), Radiology, business, medicine.drug, Neuroradiology
Published
2020

147. Polymethyl Methacrylate Cranioplasty Is an Effective Ultrasound Window to Explore Intracranial Structures: Preliminary Experience and Future Perspectives

Author

Lucio Aniello Mazzeo, Francesco Guerrini, Gianluca Grimod, Andrea Salmaggi, and Giannantonio Spena

Subjects
medicine.diagnostic_test, Polymethyl methacrylate, business.industry, medicine.medical_treatment, Ultrasound, Window (computing), Magnetic resonance imaging, Computed tomography, Cranioplasty, 03 medical and health sciences, 0302 clinical medicine, Ultrasound probe, 030220 oncology & carcinogenesis, medicine, Surgery, In patient, Neurology (clinical), business, Nuclear medicine, 030217 neurology & neurosurgery
Abstract

Objective To evaluate the feasibility of transcranial sonography in patients harboring polymethylmethacrylate cranioplasties (PMMA-CP) and explore whether this material is a valid sonic window to explore intracerebral structures. Methods In 6 patients, we performed transcranial sonography (TCS), using the PMMA-CP as sonic window. To test the reliability of ultrasound images, we collected several quantitative and qualitative measurements of intracranial structures and compared these sonographic images with standard computed tomography (CT) scan images. Results We found that PMMA-CP is a very good sonic window and allowed us to obtain very good quality echographic images of intracranial structures, as shown by the comparison of measurements with CT scan, which were very reliable. The main drawback was related to the shape (i.e., the curvature) of the cranial flap, which hindered the ultrasound probe from correctly adhering to the scalp. Conclusions Although limited by the restricted number of cases, this preliminary experience represents the first available data about the serial use of TCS using PMMA-CP as window. These results open the path to the routine use of TCS to longitudinally control patients already harboring PMMA-CP. More, we here discuss its potential role in globally reducing the number of follow-up CT and magnetic resonance imaging scans required in different type of patients and pathologies.

Published
2019

150. The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia.

Author

Omar Sharif, Riem Gawish, Joanna M Warszawska, Rui Martins, Karin Lakovits, Anastasiya Hladik, Bianca Doninger, Julia Brunner, Ana Korosec, Roland E Schwarzenbacher, Tiina Berg, Robert Kralovics, Jacques Colinge, Ildiko Mesteri, Susan Gilfillan, Andrea Salmaggi, Admar Verschoor, Marco Colonna, and Sylvia Knapp

Subjects
Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
Abstract

Phagocytosis and inflammation within the lungs is crucial for host defense during bacterial pneumonia. Triggering receptor expressed on myeloid cells (TREM)-2 was proposed to negatively regulate TLR-mediated responses and enhance phagocytosis by macrophages, but the role of TREM-2 in respiratory tract infections is unknown. Here, we established the presence of TREM-2 on alveolar macrophages (AM) and explored the function of TREM-2 in the innate immune response to pneumococcal infection in vivo. Unexpectedly, we found Trem-2(-/-) AM to display augmented bacterial phagocytosis in vitro and in vivo compared to WT AM. Mechanistically, we detected that in the absence of TREM-2, pulmonary macrophages selectively produced elevated complement component 1q (C1q) levels. We found that these increased C1q levels depended on peroxisome proliferator-activated receptor-δ (PPAR-δ) activity and were responsible for the enhanced phagocytosis of bacteria. Upon infection with S. pneumoniae, Trem-2(-/-) mice exhibited an augmented bacterial clearance from lungs, decreased bacteremia and improved survival compared to their WT counterparts. This work is the first to disclose a role for TREM-2 in clinically relevant respiratory tract infections and demonstrates a previously unknown link between TREM-2 and opsonin production within the lungs.

Published
2014
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