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101. Switch from Enfuvirtide to Raltegravir in Virologically Suppressed Multidrug-Resistant HIV-1–Infected Patients: A Randomized Open-Label Trial

Author: EASIER ANRS 138 study group, De Castro, Nathalie, Braun, Joséphine, Charreau, Isabelle, Pialoux, Gilles, Cotte, Laurent, Katlama, Christine, Raffi, François, Weiss, Laurence, Meynard, Jean-Luc, Yazdanpanah, Yazdan, Delaugerre, Constance, Madelaine-Chambrin, Isabelle, Aboulker, Jean-Pierre, and Molina, Jean-Michel
Published: 2009

102. Dolutegravir Monotherapy as Maintenance Strategy:A Meta-Analysis of Individual Participant Data From Randomized Controlled Trials

Author: Fournier, Anna L, Hocqueloux, Laurent, Braun, Dominique L, Metzner, Karin J, Kouyos, Roger D, Raffi, François, Briant, Anaïs R, Martinez, Esteban, De Lazzari, Elisa, Negredo, Eugenia, Rijnders, Bart, Rokx, Casper, Günthard, Huldrych F, Parienti, Jean-Jacques, Fournier, Anna L, Hocqueloux, Laurent, Braun, Dominique L, Metzner, Karin J, Kouyos, Roger D, Raffi, François, Briant, Anaïs R, Martinez, Esteban, De Lazzari, Elisa, Negredo, Eugenia, Rijnders, Bart, Rokx, Casper, Günthard, Huldrych F, and Parienti, Jean-Jacques
Abstract: Background: Dolutegravir monotherapy (DTG-m) results in virological failure (VF) in some people with human immunodeficiency virus (PWH). We sought to identify the independent factors associated with the risk of VF and to explore the effect size heterogeneity between subgroups of PWH enrolled in DTG-m trials. Methods: We searched for randomized clinical trials (RCTs) evaluating DTG-m versus combined antiretroviral therapy (cART) among PWH virologically controlled for at least 6 months on cART. We performed an individual participant data meta-analysis of VF risk factors and quantified their explained heterogeneity in random-effect models. Definition of VF was a confirmed plasma human immunodeficiency virus (HIV)-1 ribonucleic acid (RNA) >50 copies/mL by week 48. Results: Among 416 PWH from 4 RCTs, DTG-m significantly increased the risk of VF (16 of 227 [7%] versus 0 of 189 for cART; risk difference 7%; 95% confidence interval [CI], 1%-2%; P = .02; I2 = 51%). Among 272 participants exposed to DTG-m, VF were more likely in participants with the following: first cART initiated ≥90 days from HIV acute infection (adjusted hazard ratio [aHR], 5.16; 95% 95% CI, 1.60-16.65), CD4 T cells nadir <350/mm3 (aHR, 12.10; 95% CI, 3.92-37.40), HIV RNA signal at baseline (aHR, 4.84; 95% CI, 3.68-6.38), and HIV-deoxyribonucleic acid (DNA) copy number at baseline ≥2.7 log/106 peripheral blood mononuclear cells (aHR, 3.81; 95% CI, 1.99-7.30). Among these independent risk factors, the largest effect size heterogeneity was found between HIV DNA subgroups (I2 = 80.2%; P for interaction = .02). Conclusions: Our study supports the importance of a large viral reservoir size for explaining DTG-m simplification strategy failure. Further studies are needed to link size and genetic diversity of the HIV-1 reservoir.
Published: 2022

103. Dolutegravir Monotherapy as Maintenance Strategy: A Meta-Analysis of Individual Participant Data From Randomized Controlled Trials

Author: Fournier, Anna L, Hocqueloux, Laurent, Braun, Dominique L, Metzner, Karin J, Kouyos, Roger D, Raffi, François, Briant, Anaïs R, Martinez, Esteban, De Lazzari, Elisa, Negredo, Eugenia, Rijnders, Bart, Rokx, Casper, Günthard, Huldrych F, Parienti, Jean-Jacques; https://orcid.org/0000-0002-4774-5590, Fournier, Anna L, Hocqueloux, Laurent, Braun, Dominique L, Metzner, Karin J, Kouyos, Roger D, Raffi, François, Briant, Anaïs R, Martinez, Esteban, De Lazzari, Elisa, Negredo, Eugenia, Rijnders, Bart, Rokx, Casper, Günthard, Huldrych F, and Parienti, Jean-Jacques; https://orcid.org/0000-0002-4774-5590
Abstract: Background Dolutegravir monotherapy (DTG-m) results in virological failure (VF) in some people with human immunodeficiency virus (PWH). We sought to identify the independent factors associated with the risk of VF and to explore the effect size heterogeneity between subgroups of PWH enrolled in DTG-m trials. Methods We searched for randomized clinical trials (RCTs) evaluating DTG-m versus combined antiretroviral therapy (cART) among PWH virologically controlled for at least 6 months on cART. We performed an individual participant data meta-analysis of VF risk factors and quantified their explained heterogeneity in random-effect models. Definition of VF was a confirmed plasma human immunodeficiency virus (HIV)-1 ribonucleic acid (RNA) >50 copies/mL by week 48. Results Among 416 PWH from 4 RCTs, DTG-m significantly increased the risk of VF (16 of 227 [7%] versus 0 of 189 for cART; risk difference 7%; 95% confidence interval [CI], 1%-2%; P = .02; I$^{2}$ = 51%). Among 272 participants exposed to DTG-m, VF were more likely in participants with the following: first cART initiated ≥90 days from HIV acute infection (adjusted hazard ratio [aHR], 5.16; 95% 95% CI, 1.60-16.65), CD4 T cells nadir <350/mm$^{3}$ (aHR, 12.10; 95% CI, 3.92-37.40), HIV RNA signal at baseline (aHR, 4.84; 95% CI, 3.68-6.38), and HIV-deoxyribonucleic acid (DNA) copy number at baseline ≥2.7 log/10$^{6}$ peripheral blood mononuclear cells (aHR, 3.81; 95% CI, 1.99-7.30). Among these independent risk factors, the largest effect size heterogeneity was found between HIV DNA subgroups (I$^{2}$ = 80.2%; P for interaction = .02). Conclusions Our study supports the importance of a large viral reservoir size for explaining DTG-m simplification strategy failure. Further studies are needed to link size and genetic diversity of the HIV-1 reservoir.
Published: 2022

104. Health-Related Quality of Life in HIV-1-Infected Patients on HAART: A Five-Years Longitudinal Analysis Accounting for Dropout in the APROCO-COPILOTE Cohort (ANRS CO-8)

Author: Protopopescu, Camelia, Marcellin, Fabienne, Spire, Bruno, Préau, Marie, Verdon, Renaud, Peyramond, Dominique, Raffi, François, Chêne, Geneviève, Leport, Catherine, and Carrieri, Maria-Patrizia
Published: 2007
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105. Remdesivir for the treatment of hospitalised patients with COVID-19: final results from the DisCoVeRy randomised, controlled, open-label trial

Author: Ader, Florence, primary, Bouscambert-Duchamp, Maude, additional, Hites, Maya, additional, Peiffer-Smadja, Nathan, additional, Poissy, Julien, additional, Belhadi, Drifa, additional, Diallo, Alpha, additional, Delmas, Christelle, additional, Saillard, Juliette, additional, Dechanet, Aline, additional, Fougerou, Claire, additional, Lê, Minh-Patrick, additional, Peytavin, Gilles, additional, Mercier, Noémie, additional, Velou, Priyanka, additional, Tubiana, Sarah, additional, Lescure, Xavier, additional, Faure, Emmanuel, additional, Nseir, Saad, additional, Richard, Jean-Christophe, additional, Wallet, Florent, additional, Goehringer, François, additional, Lefèvre, Benjamin, additional, Kimmoun, Antoine, additional, Raffi, François, additional, Gaborit, Benjamin, additional, Reignier, Jean, additional, Lanoix, Jean-Philippe, additional, Andrejak, Claire, additional, Zerbib, Yoann, additional, Bani-Sadr, Firouzé, additional, Mourvilliers, Bruno, additional, Danion, François, additional, Ruch, Yvon, additional, Clere-Jehl, Raphaël, additional, Le Moing, Vincent, additional, Klouche, Kada, additional, Lacombe, Karine, additional, Martin-Blondel, Guillaume, additional, Vardon-Bounes, Fanny, additional, Cabié, André, additional, Turmel, Jean-Marie, additional, Piroth, Lionel, additional, Blot, Mathieu, additional, Botelho-Nevers, Élisabeth, additional, Gagneux-Brunon, Amandine, additional, Thiery, Guillaume, additional, Bénézit, François, additional, Gaci, Rostane, additional, Mootien, Joy, additional, Gallien, Sébastien, additional, Garot, Denis, additional, Bouiller, Kevin, additional, Epelboin, Loïc, additional, Jauréguiberry, Stéphane, additional, Gaymard, Alexandre, additional, Verschelden, Gil, additional, Braz, Sandra, additional, Ferreira Ribeiro, Joao Miguel, additional, Joannidis, Michael, additional, Staub, Thérèse, additional, Altdorfer, Antoine, additional, Greil, Richard, additional, Egle, Alexander, additional, Guedj, Jérémie, additional, Noret, Marion, additional, Roncon-Albuquerque, Roberto, additional, Paiva, Jose-Artur, additional, Lina, Bruno, additional, Costagliola, Dominique, additional, Yazdanpanah, Yazdan, additional, Burdet, Charles, additional, and Mentré, France, additional
Published: 2022
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106. Dolutegravir Monotherapy as Maintenance Strategy: A Meta-Analysis of Individual Participant Data From Randomized Controlled Trials

Author: Fournier, Anna L, primary, Hocqueloux, Laurent, additional, Braun, Dominique L, additional, Metzner, Karin J, additional, Kouyos, Roger D, additional, Raffi, François, additional, Briant, Anaïs R, additional, Martinez, Esteban, additional, De Lazzari, Elisa, additional, Negredo, Eugenia, additional, Rijnders, Bart, additional, Rokx, Casper, additional, Günthard, Huldrych F, additional, and Parienti, Jean-Jacques, additional
Published: 2022
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107. A highly virulent variant of HIV-1 circulating in the Netherlands

Author: Wymant, Chris, Bezemer, Daniela, Blanquart, François, Ferretti, Luca, Gall, Astrid, Hall, Matthew, Golubchik, Tanya, Bakker, Margreet, Ong, Swee Hoe, Zhao, Lele, Bonsall, David, de Cesare, Mariateresa, MacIntyre-Cockett, George, Abeler-Dörner, Lucie, Albert, Jan, Bannert, Norbert, Fellay, Jacques, Grabowski, M Kate, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych F, Kivelä, Pia, Kouyos, Roger D, Laeyendecker, Oliver, Meyer, Laurence, Porter, Kholoud, Ristola, Matti, van Sighem, Ard, Berkhout, Ben, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Fraser, Christophe, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, C A, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B Martinez, Marzolini, C, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Weber, R, Yerly, S, van der Valk, M, Geerlings, S E, Goorhuis, A, Hovius, J W, Lempkes, B, Nellen, F J B, van der Poll, T, Prins, J M, Reiss, P, van Vugt, M, Wiersinga, W J, Wit, F W M N, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A M H, Pijnappel, F J J, Smalhout, S Y, Weijsenfeld, A M, Jurriaans, S, Back, N K T, Zaaijer, H L, Berkhout, B, Cornelissen, M T E, Schinkel, C J, Wolthers, K C, Peters, E J G, van Agtmael, M A, Autar, R S, Bomers, M, Sigaloff, K C E, Heitmuller, M, Laan, L M, Ang, C W, van Houdt, R, Jonges, M, Kuijpers, T W, Pajkrt, D, Scherpbier, H J, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Looff, L, Buiting, A, Reuwer, A, Veenemans, J, Wintermans, B, Pronk, M J H, Ammerlaan, H S M, van den Bersselaar, D N J, de Munnik, E S, Deiman, B, Jansz, A R, Scharnhorst, V, Tjhie, J, Wegdam, M C A, van Eeden, A, Nellen, J, Brokking, W, Elsenburg, L J M, Nobel, H, van Kasteren, M E E, Berrevoets, M A H, Brouwer, A E, Adams, A, van Erve, R, de Kruijf-van de Wiel, B A F M, Keelan-Phaf, S, van der Ven, B, Buiting, A G M, Murck, J L, de Vries-Sluijs, T E M S, Bax, H I, van Gorp, E C M, de Jong-Peltenburg, N C, de Mendonç A Melo, M, van Nood, E, Nouwen, J L, Rijnders, B J A, Rokx, C, Schurink, C A M, Slobbe, L, Verbon, A, Bassant, N, van Beek, J E A, Vriesde, M, van Zonneveld, L M, de Groot, J, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Fraaij, P L A, van Rossum, A M C, Vermont, C L, van der Knaap, L C, Visser, E, Branger, J, Douma, R A, Cents-Bosma, A S, Duijf-van de Ven, C J H M, Schippers, E F, van Nieuwkoop, C, van Ijperen, J M, Geilings, J, van der Hut, G, van Burgel, N D, Leyten, E M S, Gelinck, L B S, Mollema, F, Davids-Veldhuis, S, Tearno, C, Wildenbeest, G S, Heikens, E, Groeneveld, P H P, Bouwhuis, J W, Lammers, A J J, Kraan, S, van Hulzen, A G W, Kruiper, M S M, van der Bliek, G L, Bor, P C J, Debast, S B, Wagenvoort, G H J, Kroon, F P, de Boer, M G J, Jolink, H, Lambregts, M M C, Roukens, A H E, Scheper, H, Dorama, W, van Holten, N, Claas, E C J, Wessels, E, den Hollander, J G, El Moussaoui, R, Pogany, K, Smit, J V, Struik-Kalkman, D, van Niekerk, T, Pontesilli, O, Lowe, S H, Oude Lashof, A M L, Posthouwer, D, van Wolfswinkel, M E, Ackens, R P, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I H M, Havenith, T R A, van Vonderen, M G A, Kampschreur, L M, Faber, S, Steeman-Bouma, R, Al Moujahid, A, Kootstra, G J, Delsing, C E, van der Burg-van de Plas, M, Scheiberlich, L, Kortmann, W, van Twillert, G, Renckens, R, Ruiter-Pronk, D, van Truijen-Oud, F A, Cohen Stuart, J W T, Jansen, E R, Hoogewerf, M, Rozemeijer, W, van der Reijden, W A, Sinnige, J C, Brinkman, K, van den Berk, G E L, Blok, W L, Lettinga, K D, de Regt, M, Schouten, W E M, Stalenhoef, J E, Veenstra, J, Vrouenraets, S M E, Blaauw, H, Geerders, G F, Kleene, M J, Kok, M, Knapen, M, van der Meché, I B, Mulder-Seeleman, E, Toonen, A J M, Wijnands, S, Wttewaal, E, Kwa, D, van Crevel, R, van Aerde, K, Dofferhoff, A S M, Henriet, S S V, Ter Hofstede, H J M, Hoogerwerf, J, Keuter, M, Richel, O, Albers, M, Grintjes-Huisman, K J T, de Haan, M, Marneef, M, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, F F, Burger, D, Gisolf, E H, Hassing, R J, Claassen, M, Ter Beest, G, van Bentum, P H M, Langebeek, N, Tiemessen, R, Swanink, C M A, van Lelyveld, S F L, Soetekouw, R, van der Prijt, L M M, van der Swaluw, J, Bermon, N, Jansen, R, Herpers, B L, Veenendaal, D, Verhagen, D W M, Lauw, F N, van Broekhuizen, M C, van Wijk, M, Bierman, W F W, Bakker, M, Kleinnijenhuis, J, Kloeze, E, Middel, A, Postma, D F, Schölvinck, E H, Stienstra, Y, Verhage, A R, Wouthuyzen-Bakker, M, Boonstra, A, de Groot-de Jonge, H, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Knoester, M, Hoepelman, A I M, Arends, J E, Barth, R E, Bruns, A H W, Ellerbroek, P M, Mudrikova, T, Oosterheert, J J, Schadd, E M, van Welzen, B J, Aarsman, K, Griffioen-van Santen, B M G, de Kroon, I, van Berkel, M, van Rooijen, C S A M, Schuurman, R, Verduyn-Lunel, F, Wensing, A M J, Bont, L J, Geelen, S P M, Loeffen, Y G T, Wolfs, T F W, Nauta, N, Rooijakkers, E O W, Holtsema, H, Voigt, R, van de Wetering, D, Alberto, A, van der Meer, I, Rosingh, A, Halaby, T, Zaheri, S, Boyd, A C, Bezemer, D O, van Sighem, A I, Smit, C, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Meijering, R, van de Sande, L, Rutkens, T, van der Vliet, S, de Groot, L, van den Akker, M, Bakker, Y, El Berkaoui, A, Bezemer, M, Brétin, N, Djoechro, E, Groters, M, Kruijne, E, Lelivelt, K J, Lodewijk, C, Lucas, E, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Schnörr, P, Scheigrond, A, Tuijn, E, Veenenberg, L, Visser, K M, Witte, E C, Van Frankenhuijsen, Maartje, Allegre, Thierry, Makhloufi, Djamila, Livrozet, Jean-Michel, Chiarello, Pierre, Godinot, Mathieu, Brunel-Dalmas, Florence, Gibert, Sylvie, Trepo, Christian, Peyramond, Dominique, Miailhes, Patrick, Koffi, Joseph, Thoirain, Valérie, Brochier, Corinne, Baudry, Thomas, Pailhes, Sylvie, Lafeuillade, Alain, Philip, Gisèle, Hittinger, Gilles, Assi, Assi, Lambry, Véronique, Rosenthal, Eric, Naqvi, Alissa, Dunais, Brigitte, Cua, Eric, Pradier, Christian, Durant, Jacques, Joulie, Aline, Quinsat, Denis, Tempesta, Serge, Ravaux, Isabelle, Martin, Isabelle Poizot, Faucher, Olivia, Cloarec, Nicolas, Champagne, Hélène, Pichancourt, Gilles, Morlat, Philippe, Pistone, Thierry, Bonnet, Fabrice, Mercie, Patrick, Faure, Isabelle, Hessamfar, Mojgan, Malvy, Denis, Lacoste, Denis, Pertusa, Marie-Carmen, Vandenhende, Marie-Anne, Bernard, Noëlle, Paccalin, François, Martell, Cédric, Roger-Schmelz, Julien, Receveur, Marie-Catherine, Duffau, Pierre, Dondia, Denis, Ribeiro, Emmanuel, Caltado, Sabrina, Neau, Didier, Dupont, Michel, Dutronc, Hervé, Dauchy, Frédéric, Cazanave, Charles, Vareil, Marc-Olivier, Wirth, Gaétane, Le Puil, Séverine, Pellegrin, Jean-Luc, Raymond, Isabelle, Viallard, Jean-François, Chaigne de Lalande, Severin, Garipuy, Daniel, Delobel, Pierre, Obadia, Martine, Cuzin, Lise, Alvarez, Muriel, Biezunski, Noemie, Porte, Lydie, Massip, Patrice, Debard, Alexa, Balsarin, Florence, Lagarrigue, Myriam, Prevoteau du Clary, François, Aquilina, Christian, Reynes, Jacques, Baillat, Vincent, Merle, Corinne, Lemoing, Vincent, Atoui, Nadine, Makinson, Alain, Jacquet, Jean Marc, Psomas, Christina, Tramoni, Christine, Aumaitre, Hugues, Saada, Mathieu, Medus, Marie, Malet, Martine, Eden, Aurélia, Neuville, Ségolène, Ferreyra, Milagros, Sotto, Albert, Barbuat, Claudine, Rouanet, Isabelle, Leureillard, Didier, Mauboussin, Jean-Marc, Lechiche, Catherine, Donsesco, Régine, Cabie, André, Abel, Sylvie, Pierre-Francois, Sandrine, Batala, Anne-Sophie, Cerland, Christophe, Rangom, Camille, Theresine, Nadine, Hoen, Bruno, Lamaury, Isabelle, Fabre, Isabelle, Schepers, Kinda, Curlier, Elodie, Ouissa, Rachida, Gaud, Catherine, Ricaud, Carole, Rodet, Roland, Wartel, Guillaume, Sautron, Carmele, Beck-Wirth, Geneviève, Michel, Catherine, Beck, Charles, Halna, Jean-Michel, Kowalczyk, Jakub, Benomar, Meryem, Drobacheff-Thiebaut, Christine, Chirouze, Catherine, Faucher, Jean-François, Parcelier, François, Foltzer, Adeline, Haffner-Mauvais, Cécile, Hustache Mathieu, Mathieu, Proust, Aurélie, Piroth, Lionel, Chavanet, Pascal, Duong, Michel, Buisson, Marielle, Waldner, Anne, Mahy, Sophie, Gohier, Sandrine, Croisier, Delphine, May, Thierry, Delestan, Mikael, Andre, Marie, Zadeh, Mahsa Mohseni, Martinot, Martin, Rosolen, Béatrice, Pachart, Anne, Martha, Benoît, Jeunet, Noëlle, Rey, David, Cheneau, Christine, Partisani, Maria, Priester, Michèle, Bernard-Henry, Claudine, Batard, Marie-Laure, Fischer, Patricia, Berger, Jean-Luc, Kmiec, Isabelle, Robineau, Olivier, Huleux, Thomas, Ajana, Faïza, Alcaraz, Isabelle, Allienne, Christophe, Baclet, Véronique, Meybeck, Agnès, Valette, Michel, Viget, Nathalie, Aissi, Emmanuelle, Biekre, Raphael, Cornavin, Pauline, Merrien, Dominique, Seghezzi, Jean-Christophe, Machado, Moise, Diab, Georges, Raffi, François, Bonnet, Bénédicte, Allavena, Clotilde, Grossi, Olivier, Reliquet, Véronique, Billaud, Eric, Brunet, Cecile, Bouchez, Sabelline, Morineau-Le Houssine, Pascale, Sauser, Fabienne, Boutoille, David, Besnier, Michel, Hue, Hervé, Hall, Nolwenn, Brosseau, Delphine, Souala, Faouzi, Michelet, Christian, Tattevin, Pierre, Arvieux, Cédric, Revest, Matthieu, Leroy, Helene, Chapplain, Jean-Marc, Dupont, Matthieu, Fily, Fabien, Patra-Delo, Solène, Lefeuvre, Céline, Bernard, Louis, Bastides, Frédéric, Nau, Pascale, Verdon, Renaud, de la Blanchardiere, Arnaud, Martin, Anne, Feret, Philippe, Geffray, Loïk, Daniel, Corinne, Rohan, Jennifer, Fialaire, Pascale, Chennebault, Jean Marie, Rabier, Valérie, Abgueguen, Pierre, Rehaiem, Sami, Luycx, Odile, Niault, Mathilde, Moreau, Philippe, Poinsignon, Yves, Goussef, Marie, Mouton-Rioux, Virginie, Houlbert, Dominique, Alvarez-Huve, Sandrine, Barbe, Frédérique, Haret, Sophie, Perre, Philippe, Leantez-Nainville, Sophie, Esnault, Jean-Luc, Guimard, Thomas, Suaud, Isabelle, Girard, Jean-Jacques, Simonet, Véronique, Debab, Yasmine, Schmit, Jean-Luc, Jacomet, Christine, Weinberck, Pierre, Genet, Claire, Pinet, Pauline, Ducroix, Sophie, Durox, Hélène, Denes, Éric, Abraham, Bruno, Gourdon, Florence, Antoniotti, Odile, Molina, Jean-Michel, Ferret, Samuel, Lascoux-Combe, Caroline, Lafaurie, Matthieu, Colin de Verdiere, Nathalie, Ponscarme, Diane, De Castro, Nathalie, Aslan, Alexandre, Rozenbaum, Willy, Pintado, Claire, Clavel, François, Taulera, Olivier, Gatey, Caroline, Munier, Anne-Lise, Gazaigne, Sandrine, Penot, Pauline, Conort, Guillaume, Lerolle, Nathalie, Leplatois, Anne, Balausine, Stéphanie, Delgado, Jeannine, Timsit, Julie, Tabet, Magda, Gerard, Laurence, Girard, Pierre-Marie, Picard, Odile, Tredup, Jürgen, Bollens, Diane, Valin, Nadia, Campa, Pauline, Bottero, Julie, Lefebvre, Benedicte, Tourneur, Muriel, Fonquernie, Laurent, Wemmert, Charlotte, Lagneau, Jean-Luc, Yazdanpanah, Yazdan, Phung, Bao, Pinto, Adriana, Vallois, Dorothée, Cabras, Ornella, Louni, Françoise, Pialoux, Gilles, Lyavanc, Thomas, Berrebi, Valérie, Chas, Julie, Lenagat, Sophie, Rami, Agathe, Diemer, Myriam, Parrinello, Maguy, Depond, Audrey, Salmon, Dominique, Guillevin, Loïc, Tahi, Tassadit, Belarbi, Linda, Loulergue, Pierre, Zak Dit Zbar, Olivier, Launay, Odile, Silbermann, Benjamin, Leport, Catherine, Alagna, Laura, Pietri, Marie-Pierre, Simon, Anne, Bonmarchand, Manuela, Amirat, Naouel, Pichon, François, Kirstetter, Myriam, Katlama, Christine, Valantin, Marc Antoine, Tubiana, Roland, Caby, Fabienne, Schneider, Luminita, Ktorza, Nadine, Calin, Ruxandra, Merlet, Audrey, Ben Abdallah, Saadia, Weiss, Laurence, Buisson, Martin, Batisse, Dominique, Karmochine, Marina, Pavie, Juliette, Minozzi, Catherine, Jayle, Didier, Castel, Philippe, Derouineau, Jean, Kousignan, Pascale, Eliazevitch, Murielle, Pierre, Isabelle, Collias, Lio, Viard, Jean-Paul, Gilquin, Jacques, Sobel, Alain, Slama, Laurence, Ghosn, Jade, Hadacek, Blanka, Thu-Huyn, Nugyen, Nait-Ighil, Lella, Cros, Agnes, Maignan, Aline, Duvivier, Claudine, Consigny, Paul Henri, Lanternier, Fanny, Shoai-Tehrani, Michka, Touam, Fatima, Jerbi, Saadia, Bodard, Loïc, Jung, Corinne, Goujard, Cécile, Quertainmont, Yann, Duracinsky, Martin, Segeral, Olivier, Blanc, Arnaud, Peretti, Delphine, Cheret, Antoine, Chantalat, Christelle, Dulucq, Marie Josée, Levy, Yves, Lelievre, Jean Daniel, Lascaux, Anne Sophie, Dumont, Cécile, Boue, François, Chambrin, Véronique, Abgrall, Sophie, Kansau, Imad, Raho-Moussa, Mariem, De Truchis, Pierre, Dinh, Aurélien, Davido, Benjamin, Marigot, Dhiba, Berthe, Huguette, Devidas, Alain, Chevojon, Pierre, Chabrol, Amélie, Agher, Nouara, Lemercier, Yvon, Chaix, Fabrice, Turpault, Isabelle, Bouchaud, Olivier, Honore, Patricia, Rouveix, Elisabeth, Reimann, Evelyne, Belan, Alix Greder, Godin Collet, Claire, Souak, Safia, Mortier, Emmanuel, Bloch, Martine, Simonpoli, Anne-Marie, Manceron, Véronique, Cahitte, Isabelle, Hiraux, Emmanuel, Lafon, Erik, Cordonnier, François, Zeng, Ai-Feng, Zucman, David, Majerholc, Catherine, Bornarel, Dominique, Uludag, Agnès, Gellen-Dautremer, Justine, Lefort, Agnès, Bazin, Christine, Daneluzzi, Vincent, Gerbe, Juliette, Jeantils, Vincent, Coupard, Mélissa, Patey, Olivier, Bantsimba, Jonas, Delllion, Sophie, Paz, Pauline Caraux, Cazenave, Benoit, Richier, Laurent, Garrait, Valérie, Delacroix, Isabelle, Elharrar, Brigitte, Vittecoq, Daniel, Bolliot, Claudine, Lepretre, Annie, Genet, Philippe, Masse, Virginie, Perrone, Véronique, Boussard, Jean-Luc, Chardon, Patricia, Froguel, Eric, Simon, Philippe, Tassi, Sylvie, Avettand Fenoel, Véronique, Barin, Francis, Bourgeois, Christine, Cardon, Fanny, Chaix, Marie-Laure, Delfraissy, Jean François, Essat, Asma, Fischer, Hugues, Lecuroux, Camille, Petrov-Sanchez, Ventzislava, Rouzioux, Christine, Saez-Cirion, Asier, Seng, Rémonie, Kuldanek, Kristin, Mullaney, Scott, Young, Carmel, Zucchetti, Antonella, Bevan, Margaret-Ann, McKernan, Sinead, Wandolo, Emily, Richardson, Celia, Youssef, Elaney, Green, Pippa, Faulkner, Sue, Faville, Rebecca, Herman, Sandra, Care, Christine, Blackman, Helen, Bellenger, Katharine, Fairbrother, Keith, Phillips, Andrew, Babiker, Abdel, Delpech, Valerie, Fidler, S, Clarke, Mindy, Fox, Julie, Gilson, R, Goldberg, David, Hawkins, David, Johnson, Anne, Johnson, Margaret, McLean, Ken, Nastouli, Eleni, Post, Frank, Kennedy, N, Pritchard, J, Andrady, U, Rajda, N, Donnelly, C, McKernan, S, Drake, S, Gilleran, G, White, D, Ross, J, Harding, J, Faville, R, Sweeney, J, Flegg, P, Toomer, S, Wilding, H, Woodward, R, Dean, G, Richardson, C, Perry, N, Gompels, M, Jennings, L, Bansaal, D, Browing, M, Connolly, L, Stanley, B, Estreich, S, Magdy, A, O'Mahony, C, Fraser, P, Jebakumar, S P R, David, L, Mette, R, Summerfield, H, Evans, M, White, C, Robertson, R, Lean, C, Morris, S, Winter, A, Faulkner, S, Goorney, B, Howard, L, Fairley, I, Stemp, C, Short, L, Gomez, M, Young, F, Roberts, M, Green, S, Sivakumar, K, Minton, J, Siminoni, A, Calderwood, J, Greenhough, D, DeSouza, C, Muthern, Lisa, Orkin, C, Murphy, S, Truvedi, M, McLean, K, Hawkins, D, Higgs, C, Moyes, A, Antonucci, S, McCormack, S, Lynn, W, Bevan, M, Fox, J, Teague, A, Anderson, J, Mguni, S, Post, F, Campbell, L, Mazhude, C, Russell, H, Carrick, G, Ainsworth, J, Waters, A, Byrne, P, Johnson, M, Kuldanek, K, Mullaney, S, Lawlor, V, Melville, R, Sukthankar, A, Thorpe, S, Murphy, C, Wilkins, E, Ahmad, S, Green, P, Tayal, S, Ong, E, Meaden, J, Riddell, L, Loay, D, Peacock, K, Blackman, H, Harindra, V, Saeed, A M, Allen, S, Natarajan, U, Williams, O, Lacey, H, Care, C, Bowman, C, Herman, S, Devendra, S V, Wither, J, Bridgwood, A, Singh, G, Bushby, S, Kellock, D, Young, S, Rooney, G, Snart, B, Currie, J, Fitzgerald, M, Arumainayyagam, J, Chandramani, S, Rajamanoharan, S, Robinson, T, Taylor, B, Brewer, C, Mayr, Christoph, Schmidt, Wolfgang, Speidel, Andrea, Strohbach, Frank, Arastéh, Keikawus, Cordes, Christiane, Stündel, Manfred, Claus, Jörg, Baumgarten, Axel, Carganico, Andreas, Ingiliz, Patrick, Dupke, Stephan, Freiwald, Matthias, Rausch, Michael, Moll, Arend, Schleehauf, Dorothea, Hintsche, Bettina, Klausen, Gerd, Jessen, Heiko, Jessen, Arne, Köppe, Siegfried, Kreckel, Peter, Schranz, Dietmar, Fischer, Klaus, Schulbin, Hubert, Speer, Miriam, Glaunsinger, Tobias, Wicke, Thomas, Bieniek, Bernhard, Hillenbrand, Heribert, Schlote, Frank, Lauenroth-Mai, Elke, Schuler, Christoph, Schürmann, Dirk, Wesselmann, Hans, Brockmeyer, Norbert, Gehring, Peter, Schmalöer, Dirk, Hower, Martin, Spornraft-Ragaller, Petra, Häussinger, Dieter, Reuter, Stefan, Esser, Stefan, Markus, Rudolf, Kreft, Burkhard, Berzow, Dirk, Christl, Andreas, Meyer, Andreas, Plettenberg, Andreas, Stoehr, Albrecht, Graefe, Katrin, Lorenzen, Thore, Adam, Axel, Schewe, Knut, Weitner, Lutwin, Fenske, Stefan, Hansen, Stefan, Stellbrink, Hans-Jürgen, Wiemer, Dorothea, Hertling, Sandra, Schmidt, Reinhold, Arbter, Peter, Claus, Bernd, Galle, Peter, Jäger, Hans, Jä Gel-Guedes, Eva, Postel, Nils, Fröschl, Monika, Spinner, Christoph, Bogner, Johannes, Salzberger, Bernd, Schölmerich, Jürgen, Audebert, Franz, Marquardt, Ties, Schaffert, Andreas, Schnaitmann, Eiko, Trein, Andreas, Frietsch, Bernhard, Müller, Marcus, Ulmer, Albrecht, Detering-Hübner, Barbara, Kern, Peter, Schubert, Franz, Dehn, Günther, Schreiber, Maria, Güler, Cengiz, Schmidt, Daniel, Meixenberger, Karolin, Medical Microbiology & Infectious Diseases, Internal Medicine, Virology, Pediatrics, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Global Health, Infectious diseases, APH - Aging & Later Life, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Internal medicine, VU University medical center, Surgery, AMS - Rehabilitation & Development, APH - Quality of Care, Psychiatry, Pediatric surgery, Neurology, Public and occupational health, APH - Mental Health, Pathology, Cardiology, ACS - Heart failure & arrhythmias, Anesthesiology, IOO, Rehabilitation medicine, Obstetrics and gynaecology, General practice, Gastroenterology and hepatology, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Medical oncology laboratory, Hematology, Epidemiology and Data Science, Physiology, Microbes in Health and Disease (MHD), University of Oxford, Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Amsterdam UMC - Amsterdam University Medical Center, The Wellcome Trust Sanger Institute [Cambridge], Karolinska Institutet [Stockholm], Robert Koch Institute [Berlin] (RKI), Ecole Polytechnique Fédérale de Lausanne (EPFL), Johns Hopkins University (JHU), Universität Zürich [Zürich] = University of Zurich (UZH), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University College of London [London] (UCL), Kymab Ltd, Cambridge, England, Institut Pasteur [Paris] (IP), This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment., We thank K. Fransen and G. Vanham for help with the Belgian data, O. Ratmann for help in identifying the Dutch clusters, K. Kusejko for testing for additional VB individuals in the SHCS, B. Foley for help with genome sharing, B. Dearlove and L. Thomson for help with software, and J. Herbeck and three other reviewers for helpful suggestions., Contributors and affiliations are listed in the supplementary materials., Department of Medicine, University of Helsinki, Infektiosairauksien yksikkö, HUS Inflammation Center, and Clinicum
Subjects: Adult, Male, HIV-1/genetics, Genotype, Anti-HIV Agents, Evolution, [SDV]Life Sciences [q-bio], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], HIV Infections/drug therapy, selection, HIV Infections, Genome, Viral, heritability, epidemic, human-immunodeficiency-virus, Evolution, Molecular, SDG 3 - Good Health and Well-being, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Humans, Viral, Phylogeny, Netherlands, Multidisciplinary, Genome, model, Virulence, transmission, Molecular, setpoint viral load, reverse-transcriptase, dynamics, Viral Load, CD4 Lymphocyte Count, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], 3121 General medicine, internal medicine and other clinical medicine, Anti-HIV Agents/therapeutic use, Mutation, HIV-1, Female, progression
Abstract: Comment in Does HIV-1 virulence matter in the ART era? Lewitus E, Rolland M. Med (N Y). 2022 Apr 8;3(4):217-219. doi: 10.1016/j.medj.2022.03.003. PMID: 35590149; International audience; We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.
Published: 2022
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108. Incidence and risk factors for recurrent sexually transmitted infections among men who have sex with men on HIV pre-exposure prophylaxis

Author: Zeggagh, Jérémy, Bauer, Rebecca, Delaugerre, Constance, Carette, Diane, Fressard, Lisa, Charreau, Isabelle, Chidiac, Christian, Pialoux, Gilles, Tremblay, Cécile, Cua, Eric, Robineau, Olivier, Raffi, François, Capitant, Catherine, Spire, Bruno, Meyer, Laurence, Molina, Jean Michel, Institut National de la Santé et de la Recherche Médicale (INSERM), Génomes, biologie cellulaire et thérapeutiques (GenCellDi (UMR_S_944)), Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), Essais Thérapeutiques et Maladies Infectieuses, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon, CHU Tenon [AP-HP], Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Université de Montréal (UdeM), CRSN/Faculté de médecine Université de Montréal, Centre Hospitalier Universitaire de Nice (CHU Nice), Centre Hospitalier Gustave Dron [Tourcoing], Dat’AIDS Study Group, Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Service des Maladies Infectieuses et Tropicales [CHU Saint Louis], Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Université Paris Cité - UFR Médecine Paris Centre [Santé] (UPC Médecine Paris Centre), Université Paris Cité (UPC), Service de maladies infectieuses et tropicales [Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Université Paris-Saclay, Génomes, biologie cellulaire et thérapeutiques (GenCellDi (U944 / UMR7212)), Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), UFR Médecine [Santé] - Université Paris Cité (UFR Médecine UPCité), and Université Paris Cité (UPCité)
Subjects: [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; Objective: High rates of sexually transmitted infections (STIs) have been reported among pre-exposure prophylaxis (PrEP) users. We wished to assess the incidence and risk factors for recurrent STIs.Design: The ANRS IPERGAY trial was a prospective study investigating PrEP among MSM and transgender women in outpatient clinics in France and Canada. In all, 429 participants were enrolled, offered up to 4 years of PrEP and screened for bacterial STIs (syphilis, chlamydia and gonorrhea) at baseline and every 6 months.Methods: STIs incidence was calculated yearly. Cox proportional hazards model regression was used to explore associations between participants characteristics at baseline and recurrent STI during follow-up.Results: Over a median follow-up of 23 months, bacterial STI incidence was 75, 33, 13, 32 and 30 per 100 person-years for all STIs, rectal STIs, syphilis, gonorrhea and chlamydia, respectively. STI incidence significantly increased from the first year to the fourth year of the study (55 vs. 90 per 100 person-years, P < 0.001). During the study period, 167 participants (39%) presented with more than one bacterial STIs which accounted for 86% of all STIs. Baseline risk factors associated with recurrent STIs in a multivariate analysis were an STI at baseline [hazards ratio: 1.48 (95% confidence interval (CI): 1.06-2.07), P = 0.02], more than eight sexual partners in prior 2 months [hazards ratio: 1.72 (95% CI: 1.21-2.43), P = 0.002] and the use of gamma-hydroxybutyrate [hazards ratio: 1.66 (95% CI: 1.16-2.38), P = 0.005].Conclusion: STI incidence was high and increased over time. Most STIs were concentrated in a high-risk group that should be targeted for future interventions.
Published: 2022
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109. Changes in Cognitive Function Over 96 Weeks in Naive Patients Randomized to Darunavir–Ritonavir Plus Either Raltegravir or Tenofovir–Emtricitabine: A Substudy of the NEAT001/ANRS143 Trial

Author: Winston, Alan, Stöhr, Wolfgang, Antinori, Andrea, Amieva, Helene, Perré, Philippe, De Wit, Stephane, Reynes, Jacques, Gompels, Mark, dʼArminio Monforte, Antonella, Gatell, Jose-Maria, Grarup, Jesper, Pozniak, Anton, Babiker, Abdel, Raffi, François, and Richert, Laura
Published: 2017
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110. Failure to achieve immunological recovery in HIV-infected patients with clinical and virological success after 10 years of combined ART: role of treatment course

Author: Raffi, François, Le Moing, Vincent, Assuied, Alex, Habak, Sofiane, Spire, Bruno, Cazanave, Charles, Billaud, Eric, Dellamonica, Pierre, Ferry, Tristan, Fagard, Catherine, Leport, Catherine, Leport, C., Raffi, F., Chêne, G., Salamon, R., Moatti, J. P., Pierret, J., Spire, B., Brun-Vézinet, F., Fleury, H., Masquelier, B., Peytavin, G., Garraffo, R., Costagliola, D., Dellamonica, P., Katlama, C., Meyer, L., Salmon, D., Sobel, A., Cuzin, L., Dupon, M., Duval, X., Le Moing, V., Marchou, B., May, T., Morlat, P., Rabaud, C., Waldner-Combernoux, A., Hardel, L., Reboud, P., Couffin-Cadiergues, S., Marchand, L., Assuied, A., Carrieri, P., Habak, S., Couturier, F., Jadand, C., Perrier, A., Préau, M., Protopopescu, C., Schmit, J. L., Chennebault, J. M., Faller, J. P., Chirouze, C., Magy-Bertrand, N., Humbert, P., Dupon, M., Longy-Boursier, M., Morlat, P., Neau, D., Granier, P., Ansart, S., Verdon, R., Merrien, D., Chevojon, P., Levy, Y., Sobel, A., Piroth, L., Perronne, C., Froguel, E., Ceccaldi, J., Chidiac, C., Grégoire, V., Reynes, J., May, T., Raffi, F., Fuzibet, J. G., Dellamonica, P., Arsac, P., Bouvet, E., Bricaire, F., Girard, P. M., Herson, S., Leport, C., Monsonego, J., Pialoux, G., Sain, O., Salmon, D., Sellier, P., Roblot, P., Bani-Sadr, F., Michelet, C., Lucht, F., Debord, T., Martin, T., De Jaureguiberry, J. P., Marchou, B., and Bernard, L.
Published: 2017
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111. Long-term efficacy and toxicity of abacavir/lamivudine/nevirapine compared to the most prescribed ARV regimens before 2013 in a French Nationwide Cohort Study

Author: de Boissieu, Paul, Dramé, Moustapha, Raffi, François, Cabie, André, Poizot-Martin, Isabelle, Cotte, Laurent, Garraffo, Rodolphe, Delobel, Pierre, Huleux, Thomas, Rey, David, and Bani-Sadr, Firouzé
Published: 2016
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112. Drug resistance and tropism as markers of the dynamics of HIV-1 DNA quasispecies in blood cells of heavily pretreated patients who achieved sustained virological suppression

Author: Gantner, Pierre, Morand-Joubert, Laurence, Sueur, Charlotte, Raffi, François, Fagard, Catherine, Lascoux-Combe, Caroline, Salmon, Dominique, Amiel, Corinne, Lambert-Niclot, Sidonie, Fofana, Djeneba Bocar, Viard, Jean-Paul, Fafi-Kremer, Samira, Rouzioux, Christine, Avettand-Fenoel, Véronique, and Ghosn, Jade
Published: 2016
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113. Limited Weight Impact After Switching From Boosted Protease Inhibitors to Dolutegravir in Persons With Human Immunodeficiency Virus With High Cardiovascular Risk: A Post Hoc Analysis of the 96-Week NEAT-022 Randomized Trial.

Author: Waters, Laura, Assoumou, Lambert, González-Cordón, Ana, Rusconi, Stefano, Domingo, Pere, Gompels, Mark, Wit, Stephane de, Raffi, François, Stephan, Christoph, Masiá, Mar, Rockstroh, Jürgen, Katlama, Christine, Behrens, Georg M N, Moyle, Graeme, Johnson, Margaret, Fox, Julie, Stellbrink, Hans-Jürgen, Guaraldi, Giovanni, Florence, Eric, and Esser, Stefan
Subjects: THERAPEUTIC use of protease inhibitors, HIV infections, CARDIOVASCULAR diseases risk factors, STATISTICS, PROTEASE inhibitors, HIV integrase inhibitors, BODY weight, DESCRIPTIVE statistics, DATA analysis, BODY mass index, PHARMACODYNAMICS
Abstract: Background In the NEAT022 trial, virologically suppressed persons with human immunodeficiency virus (HIV) at high cardiovascular risk switching from protease inhibitors to dolutegravir either immediately (DTG-I) or after 48 weeks (DTG-D) showed noninferior virological suppression and significant lipid and cardiovascular disease risk reductions on switching to dolutegravir relative to continuing protease inhibitors. Methods In post hoc analysis, major endpoints were 48-week and 96-week weight and body mass index (BMI) changes. Factors associated with weight/BMI changes within the first 48 weeks of DTG exposure, proportion of participants by category of percentage weight change, proportions of BMI categories over time, and impact on metabolic outcomes were also assessed. Results Between May 2014 and November 2015, 204 (DTG-I) and 208 (DTG-D) participants were included. Weight significantly increased (mean, +0.810 kg DTG-I arm, and +0.979 kg DTG-D arm) in the first 48 weeks postswitch, but remained stable from 48 to 96 weeks in DTG-I arm. Switching from darunavir, White race, total to high-density lipoprotein cholesterol ratio <3.7, and normal/underweight BMI were independently associated with higher weight/BMI gains. The proportion of participants with ≥5% weight change increased similarly in both arms over time. The proportions of BMI categories, use of lipid-lowering drugs, diabetes and/or use of antidiabetic agents, and hypertension and/or use of antihypertensive agents did not change within or between arms at 48 and 96 weeks. Conclusions Switching from protease inhibitors to dolutegravir in persons with HIV with high cardiovascular risk led to modest weight gain limited to the first 48 weeks, which involved preferentially normal-weight or underweight persons and was not associated with negative metabolic outcomes. Clinical Trials Registration NCT02098837 and EudraCT 2013-003704-39. [ABSTRACT FROM AUTHOR]
Published: 2023
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114. An open-label randomized, controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19 – Final results from the DisCoVeRy trial

Author: Ader, Florence, primary, Peiffer-Smadja, Nathan, additional, Poissy, Julien, additional, Bouscambert-Duchamp, Maude, additional, Belhadi, Drifa, additional, Diallo, Alpha, additional, Delmas, Christelle, additional, Saillard, Juliette, additional, Dechanet, Aline, additional, Mercier, Noémie, additional, Dupont, Axelle, additional, Alfaiate, Toni, additional, Lescure, François-Xavier, additional, Raffi, François, additional, Goehringer, François, additional, Kimmoun, Antoine, additional, Jaureguiberry, Stéphane, additional, Reignier, Jean, additional, Nseir, Saad, additional, Danion, François, additional, Clere-Jehl, Raphael, additional, Bouiller, Kévin, additional, Navellou, Jean-Christophe, additional, Tolsma, Violaine, additional, Cabie, André, additional, Dubost, Clément, additional, Courjon, Johan, additional, Leroy, Sylvie, additional, Mootien, Joy, additional, Gaci, Rostane, additional, Mourvillier, Bruno, additional, Faure, Emmanuel, additional, Pourcher, Valérie, additional, Gallien, Sébastien, additional, Launay, Odile, additional, Lacombe, Karine, additional, Lanoix, Jean-Philippe, additional, Makinson, Alain, additional, Martin-Blondel, Guillaume, additional, Bouadma, Lila, additional, Botelho-Nevers, Elisabeth, additional, Gagneux-Brunon, Amandine, additional, Epaulard, Olivier, additional, Piroth, Lionel, additional, Wallet, Florent, additional, Richard, Jean-Christophe, additional, Reuter, Jean, additional, Staub, Thérèse, additional, Lina, Bruno, additional, Noret, Marion, additional, Andrejak, Claire, additional, Lê, Minh Patrick, additional, Peytavin, Gilles, additional, Hites, Maya, additional, Costagliola, Dominique, additional, Yazdanpanah, Yazdan, additional, Burdet, Charles, additional, and Mentre, France, additional
Published: 2022
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115. A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial

Author: Landman, Roland, primary, de Truchis, Pierre, additional, Assoumou, Lambert, additional, Lambert, Sidonie, additional, Bellet, Jonathan, additional, Amat, Karine, additional, Lefebvre, Bénédicte, additional, Allavena, Clotilde, additional, Katlama, Christine, additional, Yazdanpanah, Yazdan, additional, Molina, Jean-Michel, additional, Petrov-Sanchez, Ventzislava, additional, Gibowski, Séverine, additional, Alvarez, Jean-Claude, additional, Leibowitch, Jacques, additional, Capeau, Jacqueline, additional, Fellahi, Soraya, additional, Duracinsky, Martin, additional, Morand-Joubert, Laurence, additional, Costagliola, Dominique, additional, Girard, Pierre-Marie, additional, LAMAURY, Isabelle, additional, BANI-SADR, Firouzé, additional, FORCE, Gilles, additional, CHABROL, Amélie, additional, CABY, Fabienne, additional, PATEY, Olivier, additional, FRESARD, Anne, additional, GAGNEUX-BRUNON, Amandine, additional, CHIROUZE, Catherine, additional, DUVIVIER, Claudine, additional, LOURENCO, Jérémie, additional, TOLSMA, Violaine, additional, JANSSEN, Cécile, additional, LEROLLE, Nathalie, additional, CATALAN, Pilartxo, additional, RAMI, Agathe, additional, DE PONTHAUD, Lucile, additional, PICHANCOURT, Gilles, additional, NASRI, Safa, additional, LANDOWSKI, Stéphanie, additional, BOTTERO, Julie, additional, MFUTILA KAYKAY, Flory, additional, PIALOUX, Gilles, additional, BOUCHAUD, Olivier, additional, ABGRALL, Sophie, additional, GATEY, Caroline, additional, WEISS, Laurence, additional, PAVIE, Juliette, additional, SALMON-CERON, Dominique, additional, ZUCMAN, David, additional, LELIEVRE, Jean-Daniel, additional, PALICH, Romain, additional, SIMON, Anne, additional, MEYOHAS, Marie-Caroline, additional, GRAS, Julien, additional, CABIE, André, additional, PIRCHER, Mathilde, additional, MORLAT, Philippe, additional, HESSAMFAR, Mojgam, additional, NEAU, Didier, additional, CAZENAVE, Charles, additional, GENET, Claire, additional, FAUCHER, Jean-François, additional, MAKHLOUFI, Djamila, additional, BOIBIEUX, André, additional, BREGIGEON-RONOT, Sylvie, additional, LAROCHE, Hélène, additional, SAUTEREAU, Aurélie, additional, REYNES, Jacques, additional, MAKINSON, Alain, additional, RAFFI, François, additional, BOLLENGIER-STRAGIER, Olivier, additional, NAQVI, Alissa, additional, CUA, Eric, additional, ROSENTHAL, Eric, additional, ARVIEUX, Cédrick, additional, BUZELE, Rodolphe, additional, REY, David, additional, BATARD, Marie-Laure, additional, BERNARD, Louis, additional, DELOBEL, Pierre, additional, PIFFAUT, Marie, additional, VERDON, Renaud, additional, PIROTH, Lionel, additional, BLOT, Mathieu, additional, LECLERCQ, Pascale, additional, SIGNORI-SCHMUCK, Anne, additional, HULEUX, Thomas, additional, MEYBECK, Agnès, additional, MAY, Thierry, additional, MIAILHES, Patrick, additional, PERPOINT, Thomas, additional, GREDER-BELAN, Alix, additional, ELHARRAR, Brigitte, additional, KHUONG, Marie-Aude, additional, POUPARD, Marie, additional, BLUM, Laurent, additional, MICHAU, Christophe, additional, PRAZUCK, Thierry, additional, PHILIBERT, Patrick, additional, SLAMA, Laurence, additional, HIKOMBO, Hitoto, additional, DARASTEANU, Iuliana, additional, GIRARD, Pierre-Marie, additional, ALVAREZ, Jean-Claude, additional, MATHEZ, Dominique, additional, DE TRUCHIS, Pierre, additional, LANDMAN, Roland, additional, MEYNARD, Jean-Luc, additional, MORAND-JOUBERT, Laurence, additional, LAMBERT, Sidonie, additional, LE DU, Damien, additional, PERRONNE, Christian, additional, ASSOUMOU, Lambert, additional, COSTAGLIOLA, Dominique, additional, MELCHIOR, Jean-Claude, additional, DURACINSKI, Martin, additional, PETROV-SANCHEZ, Ventzislava, additional, AMAT, Karine, additional, BENALYCHERIF, Aïda, additional, SYLLA, Babacar, additional, GELLEY, Ambre, additional, GIBOWSKI, Séverine, additional, LE MEUT, Guillaume, additional, THIEBAUT, Rodolphe, additional, CLUMECK, Nathan, additional, LECLERCQ, Vincent, additional, CECCHERINI-SILBERSTEIN, Francesca, additional, and DECOSTER, Laurent, additional
Published: 2022
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116. Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial

Author: Ader, Florence, primary, Bouscambert-Duchamp, Maude, additional, Hites, Maya, additional, Peiffer-Smadja, Nathan, additional, Poissy, Julien, additional, Belhadi, Drifa, additional, Diallo, Alpha, additional, Lê, Minh-Patrick, additional, Peytavin, Gilles, additional, Staub, Thérèse, additional, Greil, Richard, additional, Guedj, Jérémie, additional, Paiva, Jose-Artur, additional, Costagliola, Dominique, additional, Yazdanpanah, Yazdan, additional, Burdet, Charles, additional, Mentré, France, additional, Egle, Alexander, additional, Joannidis, Michael, additional, Lamprecht, Bernd, additional, Altdorfer, Antoine, additional, Belkhir, Leila, additional, Fraipont, Vincent, additional, Verschelden, Gil, additional, Aboab, Jérôme, additional, Ader, Florence, additional, Ait-Oufella, Hafid, additional, Andrejak, Claire, additional, Andreu, Pascal, additional, Argaud, Laurent, additional, Bani-Sadr, Firouzé, additional, Benezit, François, additional, Blot, Mathieu, additional, Botelho-Nevers, Elisabeth, additional, Bouadma, Lila, additional, Bouchaud, Olivier, additional, Bougon, David, additional, Bouiller, Kevin, additional, Bounes-Vardon, Fanny, additional, Boutoille, David, additional, Boyer, Alexandre, additional, Bruel, Cédric, additional, Cabié, André, additional, Canet, Emmanuel, additional, Cazanave, Charles, additional, Chabartier, Cyrille, additional, Chirouze, Catherine, additional, Clere-Jehl, Raphaël, additional, Courjon, Johan, additional, Crockett, Flora, additional, Danion, François, additional, Delbove, Agathe, additional, Dellamonica, Jean, additional, Djossou, Félix, additional, Dubost, Clément, additional, Duvignaud, Alexandre, additional, Epaulard, Olivier, additional, Epelboin, Loïc, additional, Fartoukh, Murielle, additional, Faure, Karine, additional, Faure, Emmanuel, additional, Ferry, Tristan, additional, Ficko, Cécile, additional, Figueiredo, Samy, additional, Gaborit, Benjamin, additional, Gaci, Rostane, additional, Gagneux-Brunon, Amandine, additional, Gallien, Sébastien, additional, Garot, Denis, additional, Geri, Guillaume, additional, Gibot, Sébastien, additional, Goehringer, François, additional, Gousseff, Marie, additional, Gruson, Didier, additional, Hansmann, Yves, additional, Hinschberger, Olivier, additional, Jaureguiberry, Stéphane, additional, Jeanmichel, Vanessa, additional, Kerneis, Solen, additional, Kimmoun, Antoine, additional, Klouche, Kada, additional, Lachâtre, Marie, additional, Lacombe, Karine, additional, Laine, Fabrice, additional, Lanoix, Jean-Philippe, additional, Launay, Odile, additional, Laviolle, Bruno, additional, Le Moing, Vincent, additional, Le Pavec, Jérôme, additional, Le Tulzo, Yves, additional, Le Turnier, Paul, additional, Lebeaux, David, additional, Lefevre, Benjamin, additional, Leroy, Sylvie, additional, Lescure, François-Xavier, additional, Lessire, Henry, additional, Leveau, Benjamin, additional, Loubet, Paul, additional, Makinson, Alain, additional, Malvy, Denis, additional, Marquette, Charles-Hugo, additional, Martin-Blondel, Guillaume, additional, Martinot, Martin, additional, Mayaux, Julien, additional, Mekontso-Dessap, Armand, additional, Meziani, Ferhat, additional, Mira, Jean-Paul, additional, Molina, Jean-Michel, additional, Monnet, Xavier, additional, Mootien, Joy, additional, Mourvillier, Bruno, additional, Murris-Espin, Marlène, additional, Navellou, Jean-Christophe, additional, Nseir, Saad, additional, Oulehri, Walid, additional, Perpoint, Thomas, additional, Pialoux, Gilles, additional, Pilmis, Benoît, additional, Piriou, Vincent, additional, Piroth, Lionel, additional, Pourcher, Valérie, additional, Quenot, Jean-Pierre, additional, Raffi, François, additional, Reignier, Jean, additional, Revest, Matthieu, additional, Richard, Jean-Christophe, additional, Riu-Poulenc, Béatrice, additional, Robert, Céline, additional, Roger, Pierre-Alexandre, additional, Roger, Claire, additional, Rouveix-Nordon, Elisabeth, additional, Ruch, Yvon, additional, Saidani, Nadia, additional, Sayre, Naomi, additional, Senneville, Eric, additional, Sotto, Albert, additional, Stefan, Francois, additional, Tacquard, Charles, additional, Terzi, Nicolas, additional, Textoris, Julien, additional, Thiery, Guillaume, additional, Timsit, Jean-François, additional, Tolsma, Violaine, additional, Turmel, Jean-Marie, additional, Valour, Florent, additional, Wallet, Florent, additional, Wattecamps, Guilhem, additional, Zerbib, Yoann, additional, Berna, Marc, additional, Reuter, Jean, additional, Braz, Sandra, additional, Ferreira Ribeiro, Joao-Miguel, additional, Paiva, José-Artur, additional, Roncon-Albuquerque, Roberto, additional, Gaymard, Alexandre, additional, Lina, Bruno, additional, Tubiana, Sarah, additional, Couffin-Cadièrgues, Sandrine, additional, Esperou, Hélène, additional, Dechanet, Aline, additional, Delmas, Christelle, additional, Fougerou, Claire, additional, Mercier, Noémie, additional, Noret, Marion, additional, Saillard, Juliette, additional, and Velou, Priyanka, additional
Published: 2022
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117. Mechanisms of Early Virologic Failure in Antiretroviral-Naive Patients Starting Protease Inhibitor-Containing Regimens: The APROVIR Study

Author: APROCO Study Group, Masquelier, Bernard, Peytavin, Gilles, Leport, Catherine, Droz, Cecile, Duran, Ségolène, Verdon, Renaud, Besnier, Jean-Marc, Chêne, Geneviève, Raffi, François, and Brun-Vézinet, Françoise
Published: 2002

118. Factors Associated with Mortality in Human Immunodeficiency Virus Type 1-Infected Adults initiating Protease Inhibitor-Containing Therapy: Role of Education Level and of Early Transaminase Level Elevation (APROCO-ANRS EP11 Study)

Author: APROCO Study Group, Lewden, Charlotte, Raffi, François, Cuzin, Lise, Cailleton, Valérie, Vildé, Jean-Louis, Chêne, Geneviéve, Allavena, Clotilde, Salamon, Roger, and Leport, Catherine
Published: 2002

119. Predictors of Long-Term Increase in CD4⁺ Cell Counts in Human Immunodeficiency Virus-Infected Patients Receiving a Protease Inhibitor-Containing Antiretroviral Regimen

Author: Le Moing, Vincent, Thiébaut, Rodolphe, Chêne, Geneviève, Leport, Catherine, Cailleton, Valérie, Michelet, Christian, Fleury, Hervé, Herson, Serge, and Raffi, François
Published: 2002

120. Once-Daily Combination Therapy with Emtricitabine, Didanosine, and Efavirenz in Human Immunodeficiency Virus-Infected Patients

Author: Montana (Agence Nationale de Recherches sur le SIDA 091) Study Group, Molina, Jean-Michel, Ferchal, Françoise, Rancinan, Corinne, Raffi, François, Rozenbaum, Willy, Sereni, Daniel, Morlat, Philippe, Journot, Valérie, Decazes, Jean-Marie, and Chêne, Geneviève
Published: 2000

121. Feasibility and efficacy of early lung cancer diagnosis with chest computed tomography in HIV-infected smokers

Author: Makinson, Alain, Eymard-Duvernay, Sabrina, Raffi, François, Abgrall, Sophie, Bommart, Sébastien, Zucman, David, Valour, Florent, Cheret, Antoine, Poizot-Martin, Isabelle, Duvivier, Claudine, Mauboussin, Jean-Marc, Bonnet, Fabrice, Tattevin, Pierre, Reynes, Jacques, and Le Moing, Vincent
Published: 2016
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122. On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection

Author: Molina, Jean-Michel, Capitant, Catherine, Spire, Bruno, Pialoux, Gilles, Cotte, Laurent, Charreau, Isabelle, Tremblay, Cecile, Le Gall, Jean-Marie, Cua, Eric, Pasquet, Armelle, Raffi, François, Pintado, Claire, Chidiac, Christian, Chas, Julie, Charbonneau, Pierre, Delaugerre, Constance, Suzan-Monti, Marie, Loze, Benedicte, Fonsart, Julien, Peytavin, Gilles, Cheret, Antoine, Timsit, Julie, Girard, Gabriel, Lorente, Nicolas, Préau, Marie, Rooney, James F., Wainberg, Mark A., Thompson, David, Rozenbaum, Willy, Doré, Veronique, Marchand, Lucie, Simon, Marie-Christine, Etien, Nicolas, Aboulker, Jean-Pierre, Meyer, Laurence, and Delfraissy, Jean-François
Published: 2015
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123. Influence of nevirapine administration on the pharmacokinetics of dolutegravir in patients infected with HIV-1

Author: Dailly, Eric, Allavena, Clotilde, Grégoire, Matthieu, Reliquet, Véronique, Bouquié, Régis, Billaud, Eric, Hernando, Hélène, Bouchez, Sabelline, Deslandes, Guillaume, Hall, Nolwenn, Jolliet, Pascale, and Raffi, François
Published: 2015
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124. Highly Active Antiretroviral Treatment Initiated Early in the Course of Symptomatic Primary HIV-1 Infection: Results of the ANRS 053 Trial

Author: Hoen, Bruno, Dumon, Béatrice, Harzic, Martine, Venet, Alain, Dubeaux, Béatrice, Lascoux, Caroline, Bourezane, Yazid, Ragnaud, Jean-Marie, Bicart-See, Alain, Raffi, François, Beauvais, Laurianne, Fleury, Hervé, and Séréni, Daniel
Published: 1999

125. Persistence and adherence to single-tablet regimens in HIV treatment: a cohort study from the French National Healthcare Insurance Database

Author: Raffi, François, Yazdanpanah, Yazdan, Fagnani, Francis, Laurendeau, Caroline, Lafuma, Antoine, and Gourmelen, Julie
Published: 2015
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126. Increased systemic immune activation and inflammatory profile of long-term HIV-infected ART-controlled patients is related to personal factors, but not to markers of HIV infection severity

Author: Bastard, Jean-Philippe, Fellahi, Soraya, Couffignal, Camille, Raffi, François, Gras, Guillaume, Hardel, Lucile, Sobel, Alain, Leport, Catherine, Fardet, Laurence, Capeau, Jacqueline, Leport, C., Raffi, F., Chêne, G., Salamon, R., Moatti, J. P., Pierret, J., Spire, B., Brun-Vézinet, F., Fleury, H., Masquelier, B., Peytavin, G., Garraffo, R., Costagliola, D., Dellamonica, P., Katlama, C., Meyer, L., Salmon, D., Sobel, A., Cuzin, L., Dupon, M., Duval, X., Le Moing, V., Marchou, B., May, T., Morlat, P., Rabaud, C., Waldner-Combernoux, A., Reboud, P., Couffin-Cadiergues, S., Marchand, L., Bouteloup, V., Bouhnik, A. D., Brunet-François, C., Caron, V., Carrieri, M. P., Courcoul, M., Couturier, F., Hardel, L., Iordache, L., Kurkdji, P., Martiren, S., Préau, M., Protopopescu, C., Surzyn, J., Taieb, A., Villes, V., Schmit, J. L., Chennebault, J. M., Faller, J. P., Magy-Bertrand, N., Chirouze, C., Humbert, P., Bouchaud, O., Dupon, M., Morlat, P., Ragnaud, J. M., Granier, P., Ansart, S., Verdon, R., Merrien, D., Chevojon, P., Sobel, A., Piroth, L., Perronne, C., Froguel, E., Ceccaldi, J., Peyramond, D., Allard, C., Le Moing, V., May, T., Raffi, F., Fuzibet, J. G., Dellamonica, P., Arsac, P., Bouvet, E., Bricaire, F., Monsonego, J., Girard, P. M., Guillevin, L., Herson, S., Leport, C., Meyohas, M. C., Molina, J. M., Pialoux, G., Sain, O., Salmon, D., Sellier, P., Roblot, F., Jaussaud, R., Michelet, C., Lucht, F., Rapp, C., Chesneau, C., De Jaureguiberry, J. P., Marchou, B., and Bernard, L.
Published: 2015
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127. Apoptosis characterizes immunological failure of HIV infected patients

Author: Mhawej, Marie-José, Brunet-François, Cécile, Fonteneau, Raphael, Ernst, Damien, Ferré, Virginie, Stan, Guy-Bart, Raffi, François, and Moog, Claude H.
Published: 2009
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128. No barrier to care, yet disparities in the HIV care continuum in France: a nationwide population study

Author: Cuzin, Lise, Allavena, Clotilde, Cotte, Laurent, Delpierre, Cyrille, Huleux, Thomas, Palich, Romain, Delobel, Pierre, Raffi, François, Cabié, André, Drobacheff-Thiébaut, C, Foltzer, A, Bouiller, K, Hustache- Mathieu, L, Chirouze, C, Lepiller, Q, Bozon, F, Babre, O, Brunel, L, Muret (Besançon), P, Laurichesse, H, LESENS, O, Vidal, M, Mrozek, N, Aumeran, C, Baud, O, Corbin, V, Letertre-Gibert, P, Casanova, S, Prouteau, J, Jacomet (Clermont Ferrand), C, Lamaury, I, Fabre, I, Curlier, E, Ouissa, R, Herrmann-Storck, C, Tressieres, B, Bonijoly, T, Receveur, M., Boulard, F, Daniel, C, Clavel (Guadeloupe), C, Merrien, D, Perré, P, Guimard, T, Bollangier, O, Leautez, S, Morrier, M, Laine (La Roche sur Yon), L, Ader, F, Becker, A, Biron, F, Boibieux, A, FERRY, T, Miailhes, P, Perpoint, T, Roux, Stéphane, Triffault-Fillit, C, Degroodt, S, Brochier, C, Valour, F, Chidiac (Lyon), C, Ménard, A, Belkhir, A., Colson, P, Dhiver, C, Madrid, A, Martin-Degiovani, M, Meddeb, L, Mokhtari, M, Motte, A, Raoux, A, Ravaux, I, Tamalet, C, Toméi, C, Tissot Dupont, H, Brégigeon, S, Zaegel-Faucher, O, Obry-Roguet, V, Laroche, H, Orticoni, M, Soavi, M., de Lamarlière, P Geneau, Ressiot, E, Ducassou, M., Jaquet, I, Galie, S, Galinier, A, Martinet, P, Landon, M, Ritleng, A., Ivanova, A, Debreux, C, Lions, C, Poizot-Martin (Marseille Ste Marguerite), I, Bigeard, B, Cabras, O, Guitteaud, K, Illiaquer, M, Marquise, A, Pierre-François, S, Pasquier, J, Rome, K, Turmel, J., Varache, C, Cabié (Martinique), A, Atoui, N, Bistoquet, M, Delaporte, E, Le Moing, V, Makinson, A, Meftah, N, de Boever, C Merle, Montes, B, Montoya Ferrer, A, Tuaillon, E, Reynes (Montpellier), J, André, M, Boyer, L, Bouillon, M., Delestan, M, Rabaud, C, May, T, Hoen (Nancy), B, Bernaud, C, Billaud, E, Biron, C, Bonnet, B, Bouchez, S, Boutoille, D, Brunet-Cartier, C, Deschanvres, C, Gaborti, B, Hall, N, Jovelin, T, Morineau, P, Reliquet, V, Sécher, S, Cavellec, M, Soria, A, Ferré, V, André-Garnier, E, Rodallec, A, Lefebvre, M, Grossi, O, Aubry, O, Raffi (Nantes), F, Pugliese, P, Breaud, S, Ceppi, C, Chirio, D, Cua, E, Dellamonica, P, Demonchy, E, De Monte, A, Durant, J, Etienne, C, Ferrando, S, Garraffo, R, Michelangeli, C, Mondain, V, Naqvi, A, Oran, N, Perbost, I, Pillet, S, Pradier, C, Prouvost-Keller, B, Risso, K, Rio, V, Roger, P., Rosenthal, E, Sausse, S, Touitou, I, Wehrlen-Pugliese, S, Zouzou (Nice), G, Hocqueloux, L, Prazuck, T, Gubavu, C, Sève, A, Maka, A, Boulard, C, Thomas, G, Botelho-Nevers, E, Gagneux-Brunon, A, Frésard, A, Ronat, V, Lucht, F, Fischer, P, Partisani, M, Cheneau, C, Priester, M, Batard, M., Bernard-Henry, C, de Mautort, E, Fafi-Kremer, S, Rey, D, Alvarez, M, Biezunski, N, Debard, A, Lansalot, P, Lelièvre, L, Martin-Blondel, G, Piffaut, M, Porte, L, Saune, K, Ajana, F, Aïssi, E, Alcaraz, I, Baclet, V, Bocket, L, Boucher, A, Choisy, P, Lafon-Desmurs, B, Meybeck, A, Pradier, M, Robineau, O, Viget, N, Valette, M, Yazdanpanah, Y, Landman, R, Duvivier, C, Valantin, M., Agher, R, Katlama, C, Flandre, P, Lortholary, O, Avettand-Fenoel, V, Rouzioux, C, Consigny, P., Cessot, G, Touam, F, Usubillaga, R, Benhadj, K, Service de maladies infectieuses et tropicales [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Service des Maladies Infectieuses et Tropicales [Hôpital Gustave Dron, Tourcoing], Centre Hospitalier Gustave Dron [Tourcoing], Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Infectious and Tropical Diseases, Nantes University Hospital, Nantes, France., CIC 1413, INSERM, Nantes, France., Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier]
Subjects: Male, Microbiology (medical), media_common.quotation_subject, [SDV]Life Sciences [q-bio], Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Men who have sex with men, MESH: Homosexuality, Male, Sexual and Gender Minorities, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Pharmacology (medical), Prospective Studies, 030212 general & internal medicine, Homosexuality, Homosexuality, Male, Prospective cohort study, media_common, Pharmacology, 030505 public health, MESH: Humans, business.industry, MESH: HIV Infections, Continuity of Patient Care, Place of birth, Care Continuum, MESH: Male, MESH: Prospective Studies, 3. Good health, MESH: France, MESH: Sexual and Gender Minorities, MESH: Continuity of Patient Care, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Population study, Female, France, 0305 other medical science, business, Viral load, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Demography
Abstract: Objectives Even in an ‘optimal’ health system, patients’ characteristics may have an impact on their care. We investigated whether age, gender and place of birth have an impact in the HIV care continuum in France, a country with a universal free healthcare system. Methods We estimated differences in the 5 year restricted mean percentage of person-time spent (i) in care, (ii) receiving ART and (iii) on ART and virally suppressed among 2432 (30.2%) women, 3925 MSM (48.7%) and 1709 men who have sex with women (MSW; 21.2%) entering care in the Dat’AIDS French prospective cohort between 1 January 2013 and 31 December 2017. Trial registration: Clinicaltrials.gov reference NCT02898987. Results Men and women spent 85.6% and 82.8% of person-time on ART and 69.9% and 65% suppressed, respectively. MSM, MSW and women spent 86.9%, 82.6% and 82.8% of person-time on ART and 72.5%, 63.7% and 65% suppressed, respectively. Patients born in France (47%) and patients born abroad spent 87.9% and 81.9% of person-time on ART and 74.6% and 62.9% suppressed, respectively. Young men born abroad were found to spend the smallest person-time with non-detectable viral load (53% for MSW and 58.1% for MSM). Conclusions Despite free access to care and universal ART in France, disparities remain in the HIV continuum care across age, country of birth and way of HIV acquisition. Clinical and public health interventions targeting specific patients’ conditions are needed.
Published: 2021
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129. XAV-19, a Swine Glyco-Humanized Polyclonal Antibody Against SARS-CoV-2 Spike Receptor-Binding Domain, Targets Multiple Epitopes and Broadly Neutralizes Variants

Author: Vanhove, Bernard, primary, Marot, Stéphane, additional, So, Ray T., additional, Gaborit, Benjamin, additional, Evanno, Gwénaëlle, additional, Malet, Isabelle, additional, Lafrogne, Guillaume, additional, Mevel, Edwige, additional, Ciron, Carine, additional, Royer, Pierre-Joseph, additional, Lheriteau, Elsa, additional, Raffi, François, additional, Bruzzone, Roberto, additional, Mok, Chris Ka Pun, additional, Duvaux, Odile, additional, Marcelin, Anne-Geneviève, additional, and Calvez, Vincent, additional
Published: 2021
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130. 536. Clinical Outcomes of Hospitalized COVID-19 Patients Treated with Remdesivir-NEAT ID 909REM Study

Author: Raffi, François, primary, Arber, Nadir, additional, Rokx, Casper, additional, Assoumou, Lambert, additional, Shah, Pallav L, additional, De Castro, Nathalie, additional, Bakhai, Ameet, additional, Soriano, Alex, additional, Mateu, Lourdes, additional, Lumbreras, Carlos, additional, Estrada, Vicente, additional, Curran, Adrian, additional, Sellier, Pierre-Olivier, additional, Duffy, Annie, additional, Fletcher, Carl, additional, Mozaffari, Essy, additional, Haubrich, Richard, additional, Hodgkins, Paul, additional, and Pozniak, Anton, additional
Published: 2021
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131. Clinical Outcomes After Treatment With Direct Antiviral Agents: Beyond The Virological Response in Patients With Previous HCV-Related Decompensated Cirrhosis

Author: PAGEAUX, Georges-Philippe, primary, NZINGA, Clovis LUSIVIKA, additional, GANNE, Nathalie, additional, SAMUEL, Didier, additional, DORIVAL, Céline, additional, ZOULIM, Fabien, additional, CAGNOT, Carole, additional, DECAENS, Thomas, additional, THABUT, Dominique, additional, ASSELAH, Tarik, additional, MATHURIN, Philippe, additional, HABERSETZER, François, additional, BRONOWICKI, Jean-Pierre, additional, GUYADER, Dominique, additional, ROSA, Isabelle, additional, LEROY, Vincent, additional, CHAZOUILLERES, Olivier, additional, DE LEDINGHEN, Victor, additional, BOURLIERE, Marc, additional, CAUSSE, Xavier, additional, CALES, Paul, additional, METIVIER, Sophie, additional, LOUSTAUD-RATTI, Véronique, additional, RIACHI, Ghassan, additional, ALRIC, Laurent, additional, GELU-SIMEON, Moana, additional, MINELLO, Anne, additional, GOURNAY, Jérôme, additional, GEIST, Claire, additional, TRAN, Albert, additional, ABERGEL, Armand, additional, PORTAL, Isabelle, additional, D’ALTEROCHE, Louis, additional, RAFFI, François, additional, FONTAINE, Hélène, additional, CARRAT, Fabrice, additional, and POL, Stanislas, additional
Published: 2021
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132. Dolutegravir efficacy at 48 weeks in key subgroups of treatment-naive HIV-infected individuals in three randomized trials

Author: Raffi, François, Rachlis, Anita, Brinson, Cynthia, Arasteh, Keikawus, Górgolas, Miguel, Brennan, Clare, Pappa, Keith, Almond, Steve, Granier, Catherine, Nichols, W. Garrett, Cuffe, Robert Liam, Jr, Joseph Eron, and Walmsley, Sharon
Published: 2015
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133. Impact of body weight on virological and immunological responses to efavirenz-containing regimens in HIV-infected, treatment-naive adults

Author: Marzolini, Catia, Sabin, Caroline, Raffi, François, Siccardi, Marco, Mussini, Cristina, Launay, Odile, Burger, David, Roca, Bernardino, Fehr, Jan, Bonora, Stefano, Mocroft, Amanda, Obel, Niels, Dauchy, Frederic-Antoine, Zangerle, Robert, Gogos, Charalambos, Gianotti, Nicola, Ammassari, Adriana, Torti, Carlo, Ghosn, Jade, Chêne, Genevieve, Grarup, Jesper, and Battegay, Manuel
Published: 2015
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134. Previously unreported emergence of A265V substitution in the integrase gene in association with bictegravir virological failure

Author: André-Garnier, Elisabeth, Hingrat, Quentin Le, Marcelin, Anne-Geneviève, Reliquet, Véronique, Malet, Isabelle, Leducq, Valentin, Rodallec, Audrey, Peytavin, Gilles, Ferré, Virginie, Charpentier, Charlotte, and Raffi, François
Published: 2020
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135. Change in HIV-1 DNA tropism despite virological success in patients receiving an enfuvirtide-based regimen

Author: Charpentier, Charlotte, Joly, Véronique, Ghosn, Jade, Yeni, Patrick, Raffi, François, Descamps, Diane, and Morand-Joubert, Laurence
Published: 2014
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136. Residual Viremia in Patients on Antiretroviral Therapy Incorporating Nevirapine Is Not Associated With the Gag-Specific Cellular Immune Response

Author: McIlroy, Dorian, Allavena, Clotilde, Rodallec, Audrey, Billaud, Eric, Ferré, Virginie, and Raffi, François
Published: 2014
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137. Switching from boosted PIs to dolutegravir decreases soluble CD14 and adiponectin in high cardiovascular risk people living with HIV

Author: Assoumou, Lambert, Moyle, Graeme, Waters, Laura, Johnson, Margaret, Domingo, Pere, Fox, Julie, Stellbrink, Hans-Jürgen, Guaraldi, Giovanni, Masiá, Mar, Gompels, Mark, De Wit, Stephane, Florence, Eric, Esser, Stefan, Raffi, François, Behrens, Georg, Pozniak, Anton, Gatell, José M., Martínez, Esteban, Vandekerckhove, Linos, Caluwé, Els, Necsoi, Coca, Van Frankenhuijsen, Maartje, Allavena, Clotilde, Reliquet, Véronique, Boutoille, David, Cavellec, Morane, André-Garnier, Elisabeth, Rodallec, Audrey, Le Tourneau, Thierry, Connault, Jérôme, Molina, Jean-Michel, Ferret, Samuel, Previlon, Miresta, Yazdanpanah, Yazdan, Landman, Roland, Joly, Véronique, Pinto, Adriana, Katlama, Christine, Caby, Fabienne, Ktorza, Nadine, Schneider, Luminita, Stephan, Christoph, Wolf, Timo, Schüttfort, Gundolf, Rockstroh, Juergen, Wasmuth, Jan-Christian, Schwarze-Zander, Carolynne, Boesecke, Christoph, Stellbrink, Hans-Jurgen, Hoffmann, Christian, Sabranski, Michael, Jablonka, Robert, Wiehler, Heidi, Stoll, Matthias, Ahrenstorf, Gerrit, Nardini, Giulia, Beghetto, Barbara, Montforte, Antonella D'Arminio, Bini, Teresa, Cogliandro, Viola, Di Pietro, Massimo, Fusco, Francesco Maria, Galli, Massimo, Rusconi, Stefano, Giacomelli, Andrea, Meraviglia, Paola, Martinez, Esteban, González-Cordón, Ana, Gatell, José Maria, Torres, Berta, Mateo, Gracia, Gutierrez, Mar, Portilla, Joaquin, Merino, Esperanza, Reus, Sergio, Boix, Vicente, Masia, Mar, Gutiérrez, Félix, Padilla, Sergio, Clotet, Bonaventura, Negredo, Eugenia, Bonjoch, Anna, Casado, José L, Bañón-Escandell, Sara, Saban, Jose, Duque, Africa, Podzamczer, Daniel, Saumoy, Maria, Acerete, Laura, Gonzalez-Garcia, Juan, Bernardino, José Ignacio, Arribas, José Ramón, Hontañón, Victor, Pagani, Nicole, Bracchi, Margherita, Vera, Jaime, Clarke, Amanda, Adams, Tanya, Richardson, Celia, Winston, Alan, Mora-Peris, Borja, Mullaney, Scott, De Esteban, Nahum, Milinkovic, Ana, Pett, Sarah, Tiraboschi, Juan Manuel, Youle, Mike, Orkin, Chloe, Rackstraw, Simon, Hand, James, Jennings, Louise, Nicholls, Jane, Johnston, Sarah, and NEAT022 Study Grp
Subjects: Microbiology (medical), medicine.medical_specialty, Pyridones, Lipopolysaccharide Receptors, Medizin, HIV Infections, Inflammation, Piperazines, chemistry.chemical_compound, Insulin resistance, Risk Factors, Internal medicine, Oxazines, medicine, Humans, Pharmacology (medical), Endothelial dysfunction, Biology, Pharmacology, Ritonavir, biology, Adiponectin, business.industry, Pharmacology. Therapy, C-reactive protein, medicine.disease, Infectious Diseases, Endocrinology, chemistry, Cardiovascular Diseases, Heart Disease Risk Factors, Heart failure, Dolutegravir, biology.protein, Human medicine, medicine.symptom, business, Heterocyclic Compounds, 3-Ring, Weight gain
Abstract: Background Switching from boosted PIs to dolutegravir in people living with HIV (PLWH) with high cardiovascular risk improved plasma lipids at 48 weeks in the NEAT022 trial. Whether this strategy may have an impact on cardiovascular biomarkers is unknown. Methods We assessed 48 week changes in biomarkers associated with inflammation, endothelial dysfunction, monocyte immune activation, oxidation, insulin resistance, hypercoagulability, heart failure, myocardial injury, and glomerular and tubular kidney injury. Results Of 415 PLWH randomized in the NEAT022 study, 313 (75.4%) remained on allocated therapy and had paired samples available. Soluble CD14 (–11%, P Conclusions Switching from boosted PIs to dolutegravir in PLWH with high cardiovascular risk led to soluble CD14 and adiponectin reductions at 48 weeks. While decreasing soluble CD14 may entail favourable health effects in PLWH, adiponectin reduction may reflect less insulin sensitivity associated with weight gain.
Published: 2021

138. Cannabis Use Is Inversely Associated with Overweight and Obesity in Hepatitis B Virus-Infected Patients (ANRS CO22 Hepather Cohort)

Author: Barré, Tangui, Pol, Stanislas, Ramier, Clémence, Di Beo, Vincent, Carrat, Fabrice, Bureau, Morgane, Bourlière, Marc, Dorival, Céline, Serfaty, Lawrence, Asselah, Tarik, Boursier, Jérôme, Marcellin, Fabienne, Carrieri, Patrizia, Fontaine, Hélène, Protopopescu, Camelia, Alric, Laurent, Bonnet, Delphine, Payssan-Sicart, Virginie, Pomes, Chloe, Zoulim, Fabien, Maynard, Marianne, Bai, Roxane, Hucault, Lucie, Bailly, François, Raffi, François, Billaud, Eric, Boutoille, David, Lefebvre, Maeva, André-Garnier, Elisabeth, Cales, Paul, Hubert, Isabelle, Lannes, Adrien, Lunel, Françoise, Boyer, Nathalie, Giuily, Nathalie, Castelnau, Corinne, Scoazec, Giovanna, Rousseaud, Emilie, Vallet-Pichard, Anaïs, Sogni, Philippe, Ledinghen, Victor De, Foucher, Juliette, Hiriart, Jean-Baptiste, M'Bouyou, Jancell, Irlès-Depé, Marie, Si Ahmed, Si Nafa, Oules, Valérie, Tran, Albert, Anty, Rodolphe, Gelsi, Eve, Truchi, Régine, Thabut, Dominique, Hammeche, Saloua, Moussali, Joseph, Causse, Xavier, Dieuleveult, Barbara De, Ouarani, Brahim, Labarrière, Damien, Ganne, Nathalie, Grando-Lemaire, Véronique, Nahon, Pierre, Brulé, Séverine, Ulker, Betul, Guyader, Dominique, Jezequel, Caroline, Brener, Audrey, Laligant, Anne, Rabot, Aline, Renard, Isabelle, Habersetzer, François, Baumert, Thomas, Doffoel, Michel, Mutter, Catherine, Simo-Noumbissie, Pauline, Razi, Esma, Bronowicki, Jean-Pierre, Barraud, Hélène, Bensenane, Mouni, Nani, Abdelbasset, Hassani-Nani, Sarah, Bernard, Marie-Albertine, Pageaux, Georges-Philippe, Larrey, Dominique, Meszaros, Magda, Metivier, Sophie, Bureau, Christophe, Morales, Thibault, Peron, Jean Marie, Robic, Marie Angèle, Decaens, Thomas, Faure, Marine, Froissart, Bruno, Hilleret, Marie-Noelle, Zarski, Jean-Pierre, Riachi, Ghassan, Goria, Odile, Paris, Fatima, Montialoux, Hélène, Leroy, Vincent, Amaddeo, Giuliana, Varaut, Anne, Simoes, Mélanie, Amzal, Rachida, Chazouillières, Olivier, Andreani, Tony, Angoulevant, Bénédicte, Chevance, Azeline, Samuel, Didier, Antonini, Teresa, Coilly, Audrey, Duclos Vallée, Jean-Charles, Tateo, Mariagrazia, Abergel, Armand, Reymond, Maud, Brigitte, Chanteranne, Benjamin, Buchard, Muti, Léon, Geist, Claire, Conroy, Guillaume, Riffault, Raphaëlle, Rosa, Isabelle, Barrault, Camille, Costes, Laurent, Hagège, Hervé, Loustaud-Ratti, Véronique, Carrier, Paul, Debette-Gratien, Maryline, Mathurin, Philippe, Lassailly, Guillaume, Lemaitre, Elise, Canva, Valérie, Dharancy, Sébastien, Louvet, Alexandre, Minello, Anne, Latournerie, Marianne, Bardou, Marc, Mouillot, Thomas, d'Alteroche, Louis, Barbereau, Didier, Nicolas, Charlotte, Elkrief, Laure, Jaillais, Anaïs, Gournay, Jérôme, Chevalier, Caroline, Archambeaud, Isabelle, Habes, Sarah, Portal, Isabelle, Gelu-Simeon, Moana, Saillard, Eric, Lafrance, Marie-Josée, Catherine, Lucie, Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépatologie médicale [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins (DS3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépato-gastro-entérologie, Assistance Publique - Hôpitaux de Marseille (APHM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Hôpital de Hautepierre [Strasbourg], Service d’Hépatologie [Hôpital Beaujon], Hôpital Beaujon [AP-HP], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), and BOURGEAIS, Véronique
Subjects: Hepatitis B virus, medicine.medical_specialty, Cirrhosis, [SDV]Life Sciences [q-bio], Aucun, Overweight, medicine.disease_cause, Virus, 03 medical and health sciences, Hepatitis B, Chronic, 0302 clinical medicine, Internal medicine, medicine, Humans, Pharmacology (medical), Obesity, ComputingMilieux_MISCELLANEOUS, Cannabis, 030304 developmental biology, Pharmacology, 0303 health sciences, biology, Cannabinoids, business.industry, Liver Neoplasms, Hepatitis B, biology.organism_classification, medicine.disease, digestive system diseases, 3. Good health, [SDV] Life Sciences [q-bio], Complementary and alternative medicine, Hepatocellular carcinoma, Cohort, cannabis, obesity, overweight, socioeconomic status, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract: International audience; Background: Chronic hepatitis B virus (HBV) infection may evolve into cirrhosis and hepatocellular carcinoma, and this progression may be accelerated by specific risk factors, including overweight and obesity. Although evidence for a protective effect of cannabis use on elevated body weight has been found for other populations, no data are available for HBV-infected patients.Aims: We aimed to identify risk factors (including cannabis use) for overweight and obesity in patients with HBV chronic infection.Methods: Using baseline data from the French ANRS CO22 Hepather cohort, we performed two separate analyses, one using “central obesity” (based on waist circumference) and the other “overweight” and “obesity” (based on body mass index) as outcomes. Logistic and multinomial regressions were used to model central obesity and overweight/obesity, respectively.Results: Among the 3706 patients in the study population, 50.8% had central obesity, 34.7% overweight, and 14.4% obesity. After multivariable adjustment, current cannabis use was associated with a 59% lower risk of central obesity compared with no lifetime use (adjusted odds ratio [95% CI]: 0.41 [0.24 to 0.70]). It was also associated with a 54% and 84% lower risk of overweight (adjusted relative risk ratio [95% CI]: 0.46 [0.27 to 0.76]) and obesity (0.16 [0.04 to 0.67]), respectively.Conclusions: Cannabis use was associated with lower risks of overweight and obesity in patients with HBV chronic infection. Future studies should test whether these potential benefits of cannabis and cannabinoid use translate into reduced liver disease progression in this high-risk population.
Published: 2021
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139. Raltegravir 1200 mg Once Daily as Maintenance Therapy in Virologically Suppressed HIV-1 Infected Adults : QDISS Open-Label Trial

Author: Hall, Nolwenn, primary, Allavena, Clotilde, additional, Katlama, Christine, additional, Jobert, Alexandra, additional, Molina, Jean-Michel, additional, Cua, Eric, additional, Bani-Sadr, Firouzé, additional, Hocqueloux, Laurent, additional, Duvivier, Claudine, additional, Merrien, Dominique, additional, Hikombo, Hitoto, additional, André-Garnier, Elisabeth, additional, Gaultier, Aurélie, additional, and Raffi, François, additional
Published: 2021
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140. Pharmacokinetics and Safety of XAV-19, a Swine Glyco-humanized Polyclonal Anti-SARS-CoV-2 Antibody, for COVID-19-Related Moderate Pneumonia: a Randomized, Double-Blind, Placebo-Controlled, Phase IIa Study

Author: Gaborit, Benjamin, primary, Dailly, Eric, additional, Vanhove, Bernard, additional, Josien, Régis, additional, Lacombe, Karine, additional, Dubee, Vincent, additional, Ferre, Virginie, additional, Brouard, Sophie, additional, Ader, Florence, additional, Vibet, Marie-Anne, additional, Le Thuaut, Aurélie, additional, Danger, Richard, additional, Flet, Laurent, additional, Omnes, Anne, additional, Berly, Laetitia, additional, Chiffoleau, Anne, additional, Jobert, Alexandra, additional, Duvaux, Odile, additional, and Raffi, François, additional
Published: 2021
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141. Influence of tenofovir, nevirapine and efavirenz on ritonavir-boosted atazanavir pharmacokinetics in HIV-infected patients

Author: Dailly, Eric, Tribut, Olivier, Tattevin, Pierre, Arvieux, Cédric, Perré, Philippe, Raffi, François, and Jolliet, Pascale
Published: 2006
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142. Self-reported side-effects of anti-retroviral treatment among IDUs: A 7-year longitudinal study (APROCO-COPILOTE COHORT ANRS CO-8)

Author: Carrieri, Maria Patrizia, Villes, Virginie, Raffi, François, Protopopescu, Camelia, Preau, Marie, Salmon, Dominique, Taieb, Audrey, Lang, Jean-Marie, Verdon, Renaud, Chene, Geneviève, and Spire, Bruno
Published: 2007
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143. A population approach to study the influence of nevirapine administration on lopinavir pharmacokinetics in HIV-1 infected patients

Author: Dailly, Eric, Reliquet, Véronique, Raffi, François, and Jolliet, Pascale
Published: 2005
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144. No relationship between high nevirapine plasma concentration and hepatotoxicity in HIV-1-infected patients naive of antiretroviral treatment or switched from protease inhibitors

Author: Dailly, Eric, Billaud, Eric, Reliquet, Véronique, Breurec, Sébastien, Perré, Philippe, Léautez, Sophie, Jolliet, Pascale, Bourin, Michel, and Raffi, François
Published: 2004
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145. Clinical Relevance of the Interaction When Switching Non-Nucleoside Reverse Transcriptase Inhibitors in Patients Infected with HIV

Author: Dailly, Eric, Allavena, Clotilde, Deslandes, Guillaume, Bouquie, Régis, Jolliet, Pascale, and Raffi, François
Published: 2014

146. Evaluation of residual viremia and quantitation of soluble CD14 in a large cohort of HIV-infected adults on a long-term non-nucleoside reverse transcriptase inhibitor-based regimen

Author: Allavena, Clotilde, Rodallec, Audrey, Sécher, Solène, Reliquet, Véronique, Baffoin, Sandrine, André-Garnier, Elisabeth, Billaud, Eric, Raffi, François, and Ferré, Virginie
Published: 2013
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147. Role and evolution of viral tropism in patients with advanced HIV disease receiving intensified initial regimen in the ANRS 130 APOLLO trial

Author: Charpentier, Charlotte, Joly, Véronique, Larrouy, Lucile, Fagard, Catherine, Visseaux, Benoit, de Verdière, Nathalie Colin, Raffi, François, Yeni, Patrick, Descamps, Diane, Aumaître, H., Medus, M., Neuville, S., Saada, M., Abgrall, S., Bentata, M., Bouchaud, O., Cailhol, J., Cordel, H., Dhote, R., Gros, H., Honoré-Berlureau, P., Huynh, T., Krivitzky, A., Mansouri, R., Poupard, M., Prendki, V., Radia, D., Rouges, F., Touam, F., Warde, B., de Castro, N., Colin de Verdière, N., Delgado, J., Ferret, S., Gallien, S., Kandel, T., Lafaurie, M., Lagrange, M., Lascoux-Combe, C., Le, D., Molina, J. M., Pavie, J., Pintado, C., Ponscarme, D., Rachline, A., Rozenbaum, W., Sereni, D., Taulera, O., Estavoyer, J. M., Faucher, J. F., Foltzer, A., Hoen, B., Hustache-Mathieu, L., Dupon, M., Dutronc, H., Neau, D., Ragnaud, J. M., Raymond, I., Boucly, S., Lortholary, O., Viard, J. P., Bechara, C., Delfraissy, J. F., Ghosn, J., Goujard, C., Kamouh, W., Môle, M., Quertainmont, Y., Bergmann, J. F., Boulanger, E., Castillo, H., Parrinello, M., Rami, A., Sellier, P., Lepeu, G., Pichancourt, G., Bernard, L., Berthé, H., Clarissou, J., Gory, M., Melchior, J. C., Perronne, C., Stegman, S., de Truchis, P., Derradji, O., Malet, M., Teicher, E., Vittecoq, D., Chakvetadze, C., Fontaine, C., Lukiana, T., Pialloux, G., Slama, L., Bonnet, D., Boucherit, S., El Alami Talbi, N., Fournier, I., Gervais, A., Joly, V., Iordache, L., Laurichesse, J. J., Leport, C., Pahlavan, G., Phung, B. C., Yeni, P., Bennamar, N., Brunet, A., Guillevin, L., Salmon-Ceron, D., Tahi, T., Chesnel, C., Dominguez, S., Jouve, P., Lelièvre, J. D., Levy, Y., Melica, G., Sobel, A., Ben Abdallah, S., Bonmarchand, M., Bricaire, F., Herson, S., Iguertsira, M., Katlama, C., Kouadio, H., Schneider, L., Simon, A., Valantin, M. A., Abel, S., Beaujolais, V., Cabié, A., Liauthaud, B., Pierre François, S., Abgueguen, P., Chennebault, J. M., Loison, J., Pichard, E., Rabier, V., Delaune, J., Louis, I., Morlat, P., Pertusa, M. C., Brunel-Delmas, F., Chiarello, P., Jeanblanc, F., Jourdain, J. J., Livrozet, J. M., Makhloufi, D., Touraine, J. L., Augustin-Normand, C., Bailly, F., Benmakhlouf, N., Brochier, C., Cotte, L., Gueripel, V., Koffi, K., Lack, P., Lebouché, B., Maynard, M., Miailhes, P., Radenne, S., Schlienger, I., Thoirain, V., Trepo, C., Drogoul, M. P., Fabre, G., Faucher, O., Frixon-Marin, V., Gastaut, J. A., Peyrouse, E., Poizot-Martin, I., Jacquet, J. M., Le Facher, G., Merle de Boever, C., Reynes, J., Tramoni, C., Allavena, C., Billaud, E., Biron, C., Bonnet, B., Bouchez, S., Boutoille, D., Brunet-François, C., Hüe, H., Mounoury, O., Raffi, F., Reliquet, V., Aubry, O., Esnault, J. L., Leautez-Nainville, S., Perré, P., Suaud, I., Bréaud, S., Ceppi, C., Dellamonica, P., De Salvador, F., Durant, J., Ferrando, S., Fuzibet, J. G., Leplatois, A., Mondain, V., Perbost, I., Pugliese, P., Rahelinirina, V., Rosenthal, E., Sanderson, F., Vassalo, M., Arvieux, C., Chapplain, J. M., Michelet, C., Ratajczak, M., Revest, M., Souala, F., Tattevin, P., Chéneau, C., Fischer, P., Lang, J. M., Partisani, M., Rey, D., Bastides, F., Besnier, J. M., Le Bret, P., Choutet, P., Dailloux, J. F., Guadagnin, P., Nau, P., Rivalain, J., Soufflet, A., Aïssi, E., Melliez, H., Pavel, S., Mouton, Y., Yazdanpanah, Y., Boyer, L., Burty, C., Letranchant, L., May, T., Wassoumbou, S., Blum, L., Danne, O., Arthus, M. A., Dion, P., Certain, A., Tabuteau, S., Beuscart, A., Agher, N., Frosch, A., Couffin-Cadiergues, S., and Diallo, A.
Published: 2013
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148. Influence of UGT1A1and SLC22A6polymorphisms on the population pharmacokinetics and pharmacodynamics of raltegravir in HIV-infected adults: a NEAT001/ANRS143 sub-study

Author: Gurjar, Rohan, Dickinson, Laura, Carr, Daniel, Stöhr, Wolfgang, Bonora, Stefano, Owen, Andrew, D’Avolio, Antonio, Cursley, Adam, De Castro, Nathalie, Fätkenheuer, Gerd, Vandekerckhove, Linos, Di Perri, Giovanni, Pozniak, Anton, Schwimmer, Christine, Raffi, François, and Boffito, Marta
Abstract: Using concentration-time data from the NEAT001/ARNS143 study (single sample at week 4 and 24), we determined raltegravir pharmacokinetic parameters using nonlinear mixed effects modelling (NONMEM v.7.3; 602 samples from 349 patients) and investigated the influence of demographics and SNPs (SLC22A6and UGT1A1) on raltegravir pharmacokinetics and pharmacodynamics. Demographics and SNPs did not influence raltegravir pharmacokinetics and no significant pharmacokinetic/pharmacodynamic relationships were observed. At week 96, UGT1A1*28/*28was associated with lower virological failure (p= 0.012), even after adjusting for baseline CD4 count (p= 0.048), but not when adjusted for baseline HIV-1 viral load (p= 0.082) or both (p= 0.089). This is the first study to our knowledge to assess the influence of SNPs on raltegravir pharmacodynamics. The lack of a pharmacokinetic/pharmacodynamic relationship is potentially an artefact of raltegravir’s characteristic high inter and intra-patient variability and also suggesting single time point sampling schedules are inadequate to thoroughly assess the influence of SNPs on raltegravir pharmacokinetics.
Published: 2023
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149. Measles seroprevalence in human immunodeficiency virus-infected adults born in the era of measles vaccination.

Author: Lefebvre, Maeva, Secher, Solène, Bouchez, Sabelline, Vandamme, Yves-Marie, Fialaire, Pascale, Leautez, Sophie, Blanchi, Sophie, Michau, Christophe, Coste-Burel, Marianne, Brunet-Cartier, Cécile, Reliquet, Véronique, Gregoire, Antoine, Raffi, François, Allavena, Clotilde, on behalf of the VIHStaRouge study group, and VIHStaRouge study group
Published: 2022
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150. Incidence and risk factors for recurrent sexually transmitted infections among MSM on HIV pre-exposure prophylaxis.

Author: Zeggagh, Jérémy, Bauer, Rebecca, Delaugerre, Constance, Carette, Diane, Fressard, Lisa, Charreau, Isabelle, Chidiac, Christian, Pialoux, Gilles, Tremblay, Cécile, Cua, Eric, Robineau, Olivier, Raffi, François, Capitant, Catherine, Spire, Bruno, Meyer, Laurence, Molina, Jean Michel, and the Ipergay Study Group, and Ipergay Study Group
Published: 2022
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