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108. ASAIO Cardiopulmonary Abstracts

Author

Shirakawa, Y., primary, Sawa, Y., additional, Nishimura, M., additional, Kagisaki, K., additional, Suhara, H., additional, Ohtake, S., additional, and Matsuda, H., additional

Published
2001
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129. Cardiac surgery in renal transplant recipients

Author

Kobayashi, Y, primary, Fukushima, N, additional, Ohtake, S, additional, Sawa, Y, additional, Nishimura, M, additional, Hirata, N, additional, Taketani, S, additional, Kokado, Y, additional, Takahara, S, additional, Okuyama, A, additional, and Matsuda, H, additional

Published
1998
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130. A long term follow-up of a randomized trial comparing interferon-α with busulfan for chronic myelogenous leukemia

Author

Ohnishi, K., primary, Tomonaga, M., additional, Kamada, N., additional, Onozawa, K., additional, Kuramoto, A., additional, Dohy, H., additional, Mizoguchi, H., additional, Miyawaki, S., additional, Tsubaki, K., additional, Miura, Y., additional, Omine, M., additional, Kobayashi, T., additional, Naoe, T., additional, Ohshima, T., additional, Hirashima, K., additional, Ohtake, S., additional, Takahashi, I., additional, Morishima, Y., additional, Naito, K., additional, Asou, N., additional, Tanimoto, M., additional, Sakuma, A., additional, and Ohno, R., additional

Published
1998
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131. Analysis of prognostic factors in newly diagnosed acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy. Japan Adult Leukemia Study Group.

Author

Asou, N, primary, Adachi, K, additional, Tamura, J, additional, Kanamaru, A, additional, Kageyama, S, additional, Hiraoka, A, additional, Omoto, E, additional, Akiyama, H, additional, Tsubaki, K, additional, Saito, K, additional, Kuriyama, K, additional, Oh, H, additional, Kitano, K, additional, Miyawaki, S, additional, Takeyama, K, additional, Yamada, O, additional, Nishikawa, K, additional, Takahashi, M, additional, Matsuda, S, additional, Ohtake, S, additional, Suzushima, H, additional, Emi, N, additional, and Ohno, R, additional

Published
1998
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134. Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4A/CDKN2, MTS2/p15INK4B, p53, and Rb genes in primary lymphoid malignancies

Author

Hangaishi, A, primary, Ogawa, S, additional, Imamura, N, additional, Miyawaki, S, additional, Miura, Y, additional, Uike, N, additional, Shimazaki, C, additional, Emi, N, additional, Takeyama, K, additional, Hirosawa, S, additional, Kamada, N, additional, Kobayashi, Y, additional, Takemoto, Y, additional, Kitani, T, additional, Toyama, K, additional, Ohtake, S, additional, Yazaki, Y, additional, Ueda, R, additional, and Hirai, H, additional

Published
1996
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142. Morphological characterization of the tunic in the edible ascidian, Halocynthia roretzi (Drasche), with remarks on ‘soft tunic syndrome’ in aquaculture.

Author

Hirose, E., Ohtake, S-I., and Azumi, K.

Subjects
*SEA squirts, *TUNICATA, *ANIMAL mortality, *ANIMAL morphology, *AQUACULTURE, *BACTERIAL cell surfaces
Abstract

‘Soft tunic syndrome’ is a serious problem in the aquaculture of the edible ascidian, Halocynthia roretzi (Drasche), and often leads to mass mortality. Here, we describe the tunic morphology of intact and diseased ascidians to reveal structural differences between them. Morphologically, diseased tunics are not very different from intact tunics, although the former are thinner and softer than the latter. While several types of cells are distributed in the tunic, the cell types and their cytomorphologies were almost identical in both groups. As bacterial/protozoan cells were not found in either intact or diseased tunics, they are not the direct cause of soft tunic syndrome. The most remarkable difference was in the bundles of tunic fibres that compose the tunic matrix; in intact tunics, the thick bundles interlace to form a firm matrix, whereas in soft tunics, the tunic fibres do not form thick bundles. Furthermore, areas of low fibre density were found in diseased tunics. Therefore, soft tunic syndrome probably causes inhibition of bundle formation and degradation of tunic bundles, creating areas of low fibre density, although the causes remain unknown. [ABSTRACT FROM AUTHOR]

Published
2009
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143. Avoidance of full-sternotomy: effect on inflammatory cytokine production during cardiopulmonary bypass in rats.

Author

Hayashi Y, Sawa Y, Nishimura M, Satoh H, Ohtake S, Matsuda H, Hayashi, Yoshitaka, Sawa, Yoshiki, Nishimura, Motonobu, Satoh, Hisashi, Ohtake, Shigeaki, and Matsuda, Hikaru

Abstract

Background and Aim Of the Study: Although open heart operations via a mini-sternotomy or mini-thoracotomy are considered "less invasive" cosmetically and are hopeful for early social recovery, clinical experiences have not shown less invasiveness toward systemic inflammatory response, because of the wide variety of patients and operative procedures encountered. We examined the effect of a mini-sternotomy on an inflammatory response during a cardiopulmonary bypass (CPB) procedure performed in rats.Methods: Thirty-two adult Sprague-Dawley (SD) rats, each of which underwent a 120-minute CPB, were randomly divided into four groups according to the method of exposing the pericardial cavity; no sternotomy (Group N [0 cm], n = 8), right para-sternal thoracotomy (Group P [2 cm], n = 8), lower mini-sternotomy (Group M [2 cm], n = 8), and full-sternotomy (Group F [4 cm], n = 8). Blood samples were obtained (1) just prior to the initiation of CPB, and then (2) 30, (3) 60, and (4) 120 minutes after the initiation of CPB.Results: Thirty minutes after the initiation of CPB, there were significant differences in plasma interleukin [IL]-6 levels between groups, except for Groups P and M; whereas at 60 minutes the only significant difference occurred between Groups N and F, and at 120 minutes there were no significant differences between any of the groups. Further, plasma IL-8 levels were not significantly different at each sampling point between all of the groups.Conclusions: These results first demonstrate experimentally that the avoidance of a full-sternotomy can be considered a less invasive strategy in terms of reducing the systemic inflammatory response that accompanies a shorter CPB duration. [ABSTRACT FROM AUTHOR]

Published
2003
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146. Salvage chemotherapy of refractory non-Hodgkin's lymphoma with aclacinomycin, behenoyl ara-C, etoposide, and prednisolone.

Author

Yoshida, Takashi, Nakamura, Shinobu, Ohtake, Shigeki, Kobayashi, Kazumi, Kanno, Masatoshi, Matsuda, Tamotsu, Matano, Sadaya, Kondo, Kunio, Okafuji, Kazuhiro, Kanai, Masanobu, Sugimoto, Rippo, Egami, Koichiro, Natori, Hideyo, Yoshida, T, Nakamura, S, Ohtake, S, Kobayashi, K, Kanno, M, Matsuda, T, and Matano, S

Abstract

A total of 40 patients with recurrent non-Hodgkin's lymphoma were treated with ABEP combination chemotherapy (aclarubicin, N4-behenoyl-1-beta-D-arabinofuranosylcytosine, etoposide, and prednisolone). A complete remission (CR) was achieved in 37.5% of the patients and partial remission, in 15.0%. The ABEP regimen proved to be effective in T-cell as well as B-cell lymphoma. It appears that the ABEP regimen may be partially non-cross-resistant with front-line doxorubicin-containing combinations. Survival for 39 months was achieved in 42.0% of the CR responders compared with 6.7% of partial responders (PRs) and nonresponders (NRs) (P less than 0.01). Disease-free survival for 45 months was seen in 66% of the CR patients. The ABEP regimen was effective in the treatment of patients with recurrent or refractory lymphoma, enabling hope for long-term survival in the majority of CR cases. [ABSTRACT FROM AUTHOR]

Published
1989
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147. Study on Bone Cell Adaptability of α-TCP/HAp Functionally Graded Porous Beads for Biomaterials Application

Author

Ohtake, S., Asaoka, T., Furukawa, K., Ushida, T., and Tateishi, T.

Abstract

Porous beads of bioactive ceramics such as HAp, TCP are considered to be promising as excellent scaffolds for cultivating bone cells. To realize this type of beads which maintains the function of scaffold with sufficient strength up to growth of new bone, and is expected to absorbed completely after the growth, a-TCP/ HAp functionally graded porous beads were fabricated. HAp is bioactive material which has both high strength and better tissue-adhesive properties, but that is not readily absorbed by the human body. On the contrary, a-TCP is highly bioabsorbable; it is quickly absorbed by the body, and, therefore, disappears before bone is completely replaced. Fabricated new beads are composed of a-TCP at the center and HAp at the surface, to control the solubility in living body. Bone cell adaptability of these beads were confirmed in vitro.

Published
2010
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148. Study on Bone Cell Adaptability of α-TCP/HAp Functionally Graded Porous Beads for Biomaterials Application

Author

Ohtake, S., Asaoka, T., Furukawa, K., Ushida, T., and Tateishi, T.

Abstract

Porous beads of bioactive ceramics such as HAp, TCP are considered to be promising as excellent scaffolds for cultivating bone cells. To realize this type of beads which maintains the function of scaffold with sufficient strength up to growth of new bone, and is expected to absorbed completely after the growth, a-TCP/ HAp functionally graded porous beads were fabricated. HAp is bioactive material which has both high strength and better tissue-adhesive properties, but that is not readily absorbed by the human body. On the contrary, a-TCP is highly bioabsorbable; it is quickly absorbed by the body, and, therefore, disappears before bone is completely replaced. Fabricated new beads are composed of a-TCP at the center and HAp at the surface, to control the solubility in living body. Bone cell adaptability of these beads were confirmed in vitro.

Published
2006
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149. Clinical application of vacuum-assisted cardiopulmonary bypass with a pressure relief valve.

Author

Hayashi, Y, Kagisaki, K, Yamaguchi, T, Sakaguchi, T, Naka, Y, Sawa, Y, Ohtake, S, and Matsuda, H

Abstract

Hemodilution induced by cardiopulmonary bypass (CPB) often prevents open heart operations without blood transfusion because of a large CPB-priming volume. A vacuum-assisted venous drainage system appears to overcome this problem and our previous experimental study demonstrated the beneficial effect of a vacuum-assisted CPB with a pressure relief valve. In this study, we clinically applied this novel system, and evaluated its efficacy by comparing it with the results of a conventional siphon-dependent drainage system.

Published
2001
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