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103. CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: An observational cohort study

Author

Mussini, C, Lorenzini, P, Cozzi Lepri, A, LAPADULA, GIUSEPPE, Marchetti, G, Nicastri, E, Cingolani, A, Lichtner, M, Antinori, A, GORI, ANDREA, Monforte, A, Moroni, M, Andreoni, M, Angarano, G, d'Arminio Monforte, A, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, C, von Schloesser, F, Viale, P, Castagna, A, Ceccherini Silberstein, F, Girardi, E, Lo Caputo, S, Puoti, M, Ammassari, A, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, M, Cinque, P, De Luca, A, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marcotullio, S, Monno, L, Quiros Roldan, E, Rusconi, S, Saracino, A, Cicconi, P, Fanti Galli, I, Tavelli, A, Giacometti, A, Costantini, A, Mazzoccato, S, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, E. Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, A, Rizzardini, G, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, M, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, D'Avino, A, Gallo, L, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Sasset, L, Mura, M, Rossetti, B, Caramello, P, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V., Mussini, C, Lorenzini, P, Cozzi Lepri, A, Lapadula, G, Marchetti, G, Nicastri, E, Cingolani, A, Lichtner, M, Antinori, A, Gori, A, Monforte, A, Moroni, M, Andreoni, M, Angarano, G, d'Arminio Monforte, A, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, C, von Schloesser, F, Viale, P, Castagna, A, Ceccherini Silberstein, F, Girardi, E, Lo Caputo, S, Puoti, M, Ammassari, A, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, M, Cinque, P, De Luca, A, Di Biagio, A, Gianotti, N, Guaraldi, G, Madeddu, G, Maggiolo, F, Marcotullio, S, Monno, L, Quiros Roldan, E, Rusconi, S, Saracino, A, Cicconi, P, Fanti Galli, I, Tavelli, A, Giacometti, A, Costantini, A, Mazzoccato, S, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, E. Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, A, Rizzardini, G, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, M, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, D'Avino, A, Gallo, L, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Sasset, L, Mura, M, Rossetti, B, Caramello, P, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Cristina, Mussini, Patrizia, Lorenzini, Alessandro, Cozzi-lepri, Giuseppe, Lapadula, Giulia, Marchetti, Emanuele, Nicastri, Antonella, Cingolani, Miriam, Lichtner, Andrea, Antinori, Andrea, Gori, Antonella D'arminio, Monforte, behalf the Icona Foundation Study Group, On, Castagna, Antonella, Mussini, Cristina, Lorenzini, Patrizia, Cozzi-Lepri, Alessandro, Lapadula, Giuseppe, Marchetti, Giulia, Nicastri, Emanuele, Cingolani, Antonella, Lichtner, Miriam, Antinori, Andrea, Gori, Andrea, Monforte, Antonella d'Arminio, Moroni, M., Andreoni, M., Angarano, G., Antinori, A., d'Arminio Monforte, A., Castelli, F., Cauda, R., Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Perno, C.F., von Schloesser, F., Viale, P., Castagna, A., Ceccherini-Silberstein, F., Cozzi-Lepri, A., Girardi, E., Lo Caputo, S., Mussini, C., Puoti, M., Ammassari, A., Balotta, C., Bonfanti, P., Bonora, S., Borderi, M., Capobianchi, M.R., Cingolani, A., Cinque, P., De Luca, A., Di Biagio, A., Gianotti, N., Gori, A., Guaraldi, G., Lapadula, G., Lichtner, M., Madeddu, Giordano, Maggiolo, F., Marchetti, G., Marcotullio, S., Monno, L., Quiros Roldan, E., Rusconi, S., Saracino, A., Cicconi, P., Fanti Galli, I., Lorenzini, P., Tavelli, A., Giacometti, A., Costantini, A., Mazzoccato, S., Santoro, C., Suardi, C., Vanino, E., Verucchi, G., Minardi, C., Quirino, T., Abeli, C., E Manconi, P., Piano, P., Vecchiet, J., Falasca, K., Sighinolfi, L., Segala, D., Mazzotta, F., Cassola, G., Viscoli, C., Alessandrini, A., Piscopo, R., Mazzarello, G., Mastroianni, C., Belvisi, V., Caramma, I., Chiodera, A., Castelli, A.P., Rizzardini, G., Ridolfo, A.L., Piolini, R., Salpietro, S., Carenzi, L., Moioli, M.C., Tincati, C., Puzzolante, C., Abrescia, N., Chirianni, A., Guida, M.G., Gargiulo, M., Baldelli, F., Francisci, D., Parruti, G., Ursini, T., Magnani, G., Ursitti, M.A., Vullo, V., D'Avino, A., Gallo, L., Nicastri, E., Acinapura, R., Capozzi, M., Libertone, R., Tebano, G., Cattelan, A., Sasset, L., Mura, M.S., Rossetti, B., Caramello, P., Orofino, G.C., Sciandra, M., Bassetti, M., Londero, A., Pellizzer, G., and Manfrin, V.

Subjects
Adult, Male, medicine.medical_specialty, Anti-HIV Agents, Epidemiology, Immunology, Infectious Diseases, Virology, CD4 Lymphocyte Count, CD4-CD8 Ratio, Cohort Studies, Female, HIV Infections, HIV-1, Humans, Italy, Middle Aged, Viral Load, Population, Infectious Disease, Settore MED/17 - MALATTIE INFETTIVE, NO, symbols.namesake, Acquired immunodeficiency syndrome (AIDS), Internal medicine, epidemiology, immunology, infectious diseases, virology, medicine, Poisson regression, education, education.field_of_study, business.industry, Adult, Anti-HIV Agents, CD4 Lymphocyte Count, CD4-CD8 Ratio, Cohort Studies, Female, HIV Infections, HIV-1, Humans, Italy, Male, Middle Aged, Viral Load, medicine.disease, Cohort, symbols, business, Viral load, Cohort study
Abstract

Background: In patients with HIV, immune reconstitution after antiretroviral therapy (ART) is often incomplete. We assessed the probability of patients reaching a CD4/CD8 ratio of 1 or more after the start of ART and its association with the onset of non-AIDS-defining events and death. Methods: We did an analysis of the ICONA cohort, which recruited treatment-naive patients with HIV in Italy. We included participants in the cohort who started ART, reached an undetectable viral load (≤80 copies per mL), and had a CD4/CD8 ratio of less than 0·8 at the time of an undetectable viral load. We defined ratio normalisation in patients as two consecutive values of 1 or more. We used Kaplan-Meier curves to estimate the cumulative probability of ratio normalisation. We then used Poisson regression models to identify factors independently associated with normalisation and with progression to non-AIDS-defining events or death. Findings: We included 3236 participants, enrolled between Jan 22, 1997, and Feb 25, 2013. At the start of ART, median CD4/CD8 ratio in our population was 0·39 (IQR 0·26-0·55). 458 (14%) patients reached a CD4/CD8 ratio of 1 or more; the estimated probability of normalisation was 4·4% (95% CI 3·7-5·2) by 1 year from baseline, 11·5% (10·2-13·0) by 2 years, and 29·4% (26·7-32·4) by 5 years. Factors associated with normalisation were high pre-ART CD4 cell counts, a high CD4/CD8 ratio at baseline, and negative cytomegalovirus serological findings. The incidence rate of non-AIDS-defining events for patients with a CD4/CD8 ratio of less than 0·30 (4·2 per 100 patient-years, 95% CI 3·4-5·3) was double that for those with a ratio of 0·30-0·45 (2·3, 2·1-2·5) or more than 0·45 (2·2, 1·7-2·9). A ratio of less than 0·30 was independently associated with an increased risk of non-AIDS-defining events or death compared with one of more than 0·45. Interpretation: Few patients had normalised CD4/CD8 ratios, even though they had viral suppression. Low ratios were associated with increased risk of serious events and deaths. The CD4/CD8 ratio could be used by clinicians to identity patients at risk of non-AIDS-related events. Funding: AbbVie, Bristol-Myers Squibb, Gilead, Janssen, Merck Sharp & Dohme, ViiV Italy.

Published
2015

104. Incidence and factors associated with the risk of sexually transmitted diseases in HIV-infected people seen for care in Italy: Data from the Icona Foundation cohort

Author

Cingolani, A, Zona, S., Girardi, E., Cozzi Lepri, A., Monno, L., Quiros Roldan, E., Guaraldi, G., Antinori, A., D'Arminio Monforte, A., Marcotullio, S., Ammassari, A., Castagna, A., Cingolani, A., De Luca, A., Di Biagio, A., Gori, A., Lazzarin, A., d'Arminio Monforte, A., Balotta, C., Perno, C. F., Mussini, C., Castelli, F., Ceccherini Silberstein, F., Maggiolo, F., von Schloesser, F., Angarano, G., DI PERRI, Giovanni, Ippolito, G., Lapadula, G., Madeddu, G., Marchetti, G., Fanti, I., Galli, L., Andreoni, M., Borderi, M., Galli, M., Lichtner, M., Moroni, M., Puoti, M., Capobianchi, M. R., Gianotti, N., Bonfanti, P., Cicconi, P., Cinque, P., Lorenzini, P., Viale, P., Cauda, R., Iardino, R., Bonora, Stefano, Lo Caputo, S., Rusconi, S., Formenti, T., Giacometti, A., Costantini, A., Mazzoccato, S., Santoro, C., Suardi, C., Vanino, E., Verucchi, G., Minardi, C., Quirino, T., Abeli, C., Manconi, P. E., Piano, P., Vecchiet, J., Falasca, K., Sighinolfi, L., Segala, D., Mazzotta, F., Cassola, G., Viscoli, C., Alessandrini, A., Piscopo, R., Mazzarello, G., Mastroianni, C., Belvisi, V., Caramma, I., Chiodera, A., Castelli, A. P., Rizzardini, G., Ridolfo, A. L., Piolini, R., Salpietro, S., Carenzi, L., Moioli, M. C., Tincati, C., Puzzolante, C., Abrescia, N., Chirianni, A., Guida, M. G., Gargiulo, M., Baldelli, F., Francisci, D., Parruti, G., Ursini, T., Magnani, G., Ursitti, M. A., Vullo, V., D'Avino, A., Gallo, L., Nicastri, E., Acinapura, R., Capozzi, M., Libertone, R., Tebano, G., Cattelan, A., Sasset, L., Mura, M. S., Rossetti, B., Caramello, P., Di Perri, G., Orofino, G. C., Bonora, S., Sciandra, M., Bassetti, M., Londero, A., Pellizzer, G., Manfrin, V., Cingolani, A., Zona, S., Girardi, E., Cozzi-Lepri, A., Monno, L., Quiros Roldan, E., Guaraldi, G., Antinori, A., D'Arminio Monforte, A., Marcotullio, F., on behalf of the Community-Oriented Study Group of the Icona Foundation Study, Group, Castagna, A, Cingolani, A, Zona, S, Girardi, E, Cozzi-Lepri, A, Monno, L, Quiros Roldan, E, Guaraldi, G, Antinori, A, D'Arminio Monforte, A, Marcotullio, S, Ammassari, A, De Luca, A, Di Biagio, A, Gori, A, Lazzarin, A, Balotta, C, Perno, C, Mussini, C, Castelli, F, Ceccherini-Silberstein, F, Maggiolo, F, von Schloesser, F, Angarano, G, Di Perri, G, Ippolito, G, Lapadula, G, Madeddu, G, Marchetti, G, Fanti, I, Galli, L, Andreoni, M, Borderi, M, Galli, M, Lichtner, M, Moroni, M, Puoti, M, Capobianchi, M, Gianotti, N, Bonfanti, P, Cicconi, P, Cinque, P, Lorenzini, P, Viale, P, Cauda, R, Iardino, R, Bonora, S, Lo Caputo, S, Rusconi, S, Formenti, T, Giacometti, A, Costantini, A, Mazzoccato, S, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, A, Rizzardini, G, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, M, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, D'Avino, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Sasset, L, Mura, M, Rossetti, B, Caramello, P, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Cingolani A, Zona S, Girardi E, Cozzi-Lepri, Monno L, Quiros Roldan E, Guaraldi G, Antinori A, D'Arminio Monforte A, Marcotullio S, Ammassari A, Castagna A, De Luca A, Di Biagio A, Gori A, Lazzarin A, d'Arminio Monforte A, Balotta C, Perno C.F, Mussini C, Castelli Fl, Ceccherini-Silberstein F, Maggiolo F, von Schloesser F, Angarano G, Di Perri G, Ippolito G, Lapadula G, Madeddu G, Marchetti G, Fanti I, Galli L, Andreoni M, Borderi M, Galli M, Lichtner M, Moroni M, Puoti M, Capobianchi M.R, Gianotti N, Bonfanti P, Cicconi P, Cinque P, Lorenzini P, Cauda R Iardino R, Bonora S, Lo Caputo S, Rusconi S, Formenti T, Giacometti A, Costantini A, Mazzoccato S, Santoro C, Suardi C, Viale P, Vanino E, Verucchi G, Castelli F, Minardi C, Quirino T, Abeli C, Manconi P.E, Piano P, Vecchiet J, Falasca K, Sighinolfi L, Segala D, Mazzotta F, Cassola G, Viscoli C, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Caramma I, Chiodera A, Castelli A.P, Rizzardini G, Ridolfo A.L, Piolini R, Salpietro S, Carenzi L, Moioli M.C, Tincati C, Puzzolante C, Abrescia N, Chirianni A, Guida M.G, Gargiulo M, Baldelli F, Francisci D, Parruti G, Ursini T, Magnani G, Ursitti M.A, Cauda R, Vullo V, d'Avino A, Gallo L, Nicastri E, Acinapura R, Capozzi M, Libertone R, Tebano G, Cattelan A, Sasset L, Mura M.S, Rossetti B, Caramello P, Orofino G.C, Sciandra M, Bassetti M, Londero A, Pellizzer G, and Manfrin V.

Subjects
Adult, Male, Health Knowledge, Attitudes, Practice, sexually transmitted diseases, Sexual Behavior, cohort, HIV, incidence, sexually transmitted diseases, Infectious Disease, Settore MED/17 - MALATTIE INFETTIVE, NO, Age Distribution, Risk Factors, HIV Seropositivity, Humans, Pharmacology (medical), Original Research, Aged, Sexually transmitted diseases, Practice, Cohort, HIV, Incidence, CD4 Lymphocyte Count, Female, Italy, Middle Aged, Sexually Transmitted Diseases, Viral Load, Health Policy, Infectious Diseases, Risk Factor, Health Knowledge, virus diseases, Sexually transmitted disease, cohort, incidence, Attitudes, Human
Abstract

Objectives: The aims of this study were to identify temporal trends in the incidence of sexually transmitted diseases (STDs) in a cohort of HIV-infected people and to evaluate factors associated with the risk of a new STD diagnosis. Methods: All HIV-infected patients in the Icona Foundation Study cohort enrolled after 1998 were included in this study. STD incidence rates (IRs) were calculated and stratified by calendar period. Predictors of STDs were identified using a Poisson regression model with sandwich estimates for standard errors. Results: Data for 9168 participants were analysed [median age 37.3 (range 18-81) years; 74% male; 30% men who have sex with men (MSM)]. Over 46736 person-years of follow-up (PYFU), 996 episodes of STDs were observed [crude IR 21.3/1000 PYFU; 95% confidence interval (CI) 20.0-22.6/1000 PYFU]. In multivariable Poisson regression analysis, MSM [rate ratio (RR) 3.03; 95% CI 2.52-3.64 versus heterosexuals], calendar period (RR 1.67; 95% CI 1.42-1.97 for 2008-2012 versus 1998-2002), HIV RNA>50 HIV-1 RNA copies/mL (RR 1.44; 95% CI 1.19-1.74 versus HIV RNA≤50 copies/mL) and a current CD4 count 500 cells/μL) were associated with an increased risk of STDs. In contrast, older age (RR 0.82 per 10 years older; 95% CI 0.77-0.89) and being currently on ART (RR 0.38; 95% CI 0.33-0.45) compared with being ART-naïve or on a treatment interruption were associated with a lower risk of developing STDs. Conclusions: An increase in the incidence of STDs was observed in more recent years. Interventions to prevent STDs and potential spread of HIV should target the younger population, MSM and people currently not receiving ART.

Published
2015

105. Evaluation of the Prognostic Value of Impaired Renal Function on Clinical Progression in a Large Cohort of HIV-Infected People Seen for Care in Italy

Author

Bandera, Alessandra, Gori, Andrea, Sabbatini, Francesca, Madeddu, Giordano, Bonora, Stefano, Libertone, Raffaella, Mastroianni, Claudio, Bonfanti, Paolo, Monforte, Antonella D'Arminio, Cozzi Lepri, Alessandro, Giacometti, A., Costantini, A., Mazzoccato, S., Angarano, G., Monno, L., Santoro, C., Maggiolo, F., Suardi, C., Viale, P., Borderi, M., Vanino, E., Verucchi, G., Castelli, Francesco, Roldan, E. Quiros, Minardi, C., Quirino, T, Abeli, C, Manconi, Paolo Emilio, Piano, Paola, Vecchiet, J., Falasca, K., Sighinolfi, L., Segala, D., Mazzotta, F., Lo Caputo, S., Cassola, G., Viscoli, C., Di Biagio, A., Alessandrini, A., Piscopo, R., Mazzarello, G., Belvisi, V., Caramma, I., Chiodera, A., Castelli, P., Moroni, M., Puoti, M., Galli, M., Lazzarin, A., Rizzardini, G., Ridolfo, A. L., Piolini, R., Rusconi, S., Balotta, C., Castagna, A., Marchetti, G., Tincati, C., Cicconi, P., Moioli, M. C., Cinque, P., Gianotti, N., Salpietro, S., Galli, L., Carenzi, L., Iardino, R., Tavelli, A., Mussini, C., Guaraldi, G., Marcotullio, S., Puzzolante, C., Lapadula, G., Abrescia, N., Chirianni, A., Borgia, G., Maddaloni, A., Gargiulo, M., Gentile, I., Orlando, R., Baldelli, F., Francisci, D., Parruti, G., Ursini, T., Magnani, G., Ursitti, M. a., Cauda, R., Antinori, A., Andreoni, M., Vullo, V., Ceccherini Silberstein, F., Cingolani, A., Girardi, E., D'Avino, A., Fanti, I., Gallo, L., Ippolito, G., Perno, C. Federico, Lichtner, M., Capobianchi, M. R., Nicastri, E., Acinapura, R., Ammassari, A., Capozzi, M., Tebano, G., Lorenzini, P., Von Schloesser, F., Zaccarelli, M., Viviani, F., Sasset, L., Mura, M. S., De Luca, A., Rossetti, B., Caramello, P., Di Perri, G., Orofino, G., Sciandra, M., Bassetti, M., Londero, A., Pellizzer, G., Manfrin, V., QUIROS ROLDAN, Maria Eugenia, Bandera, A, Gori, A, Sabbatini, F, Madeddu, G, Bonora, S, Libertone, R, Mastroianni, C, Bonfanti, P, Monforte, A, Cozzi Lepri, A, Giacometti, A, Costantini, A, Mazzoccato, S, Angarano, G, Monno, L, Santoro, C, Maggiolo, F, Suardi, C, Viale, P, Borderi, M, Vanino, E, Verucchi, G, Castelli, F, Roldan, E, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Lo Caputo, S, Cassola, G, Viscoli, C, Di Biagio, A, Alessandrini, A, Piscopo, R, Mazzarello, G, Belvisi, V, Caramma, I, Chiodera, A, Castelli, P, Moroni, M, Puoti, M, Galli, M, Lazzarin, A, Rizzardini, G, Ridolfo, A, Piolini, R, Rusconi, S, Balotta, C, Castagna, A, Marchetti, G, Tincati, C, Cicconi, P, Moioli, M, Cinque, P, Gianotti, N, Salpietro, S, Galli, L, Carenzi, L, Iardino, R, Tavelli, A, Mussini, C, Guaraldi, G, Marcotullio, S, Puzzolante, C, Lapadula, G, Abrescia, N, Chirianni, A, Borgia, G, Maddaloni, A, Gargiulo, M, Gentile, I, Orlando, R, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Cauda, R, Antinori, A, Andreoni, M, Vullo, V, Ceccherini Silberstein, F, Cingolani, A, Girardi, E, D'Avino, A, Fanti, I, Gallo, L, Ippolito, G, Perno, C, Lichtner, M, Capobianchi, M, Nicastri, E, Acinapura, R, Ammassari, A, Capozzi, M, Tebano, G, Lorenzini, P, Von Schloesser, F, Zaccarelli, M, Viviani, F, Sasset, L, Mura, M, De Luca, A, Rossetti, B, Caramello, P, Di Perri, G, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Bandera, Alessandra, Gori, Andrea, Sabbatini, Francesca, Madeddu, Giordano, Bonora, Stefano, Libertone, Raffaella, Mastroianni, Claudio, Bonfanti, Paolo, D'Arminio Monforte, Antonella, Cozzi-Lepri, Alessandro, on behalf the Icona Foundation Study, Group, Castagna, Antonella, Monforte, Antonella D'arminio, Cozzi-lepri, Alessandro, Giacometti, A., Costantini, A., Mazzoccato, S., Angarano, G., Monno, L., Santoro, C., Maggiolo, F., Suardi, C., Viale, P., Borderi, M., Vanino, E., Verucchi, G., Castelli, F., Roldan, E. Quiro, Minardi, C., Manconi, Paolo Emilio, Piano, Paola, Vecchiet, J., Falasca, K., Sighinolfi, L., Segala, D., Mazzotta, F., Lo Caputo, S., Cassola, G., Viscoli, C., Di Biagio, A., Alessandrini, A., Piscopo, R., Mazzarello, G., Belvisi, V., Caramma, I., Chiodera, A., Castelli, P., Moroni, M., Puoti, M., Galli, M., Lazzarin, A., Rizzardini, G., Ridolfo, A. L., Piolini, R., Rusconi, S., Balotta, C., Castagna, A., Marchetti, G., Tincati, C., Cicconi, P., Moioli, M. C., Cinque, P., Gianotti, N., Salpietro, S., Galli, L., Carenzi, L., Iardino, R., Tavelli, A., Mussini, C., Guaraldi, G., Marcotullio, S., Puzzolante, C., Lapadula, G., Abrescia, N., Chirianni, A., Borgia, G., Maddaloni, A., Gargiulo, M., Gentile, I., Orlando, R., Baldelli, F., Francisci, D., Parruti, G., Ursini, T., Magnani, G., Ursitti, M. A., Cauda, R., Antinori, A., Andreoni, M., Vullo, V., Ceccherini-silberstein, F., Cingolani, A., Girardi, E., D'Avino, A., Fanti, I., Gallo, L., Ippolito, G., Perno, C. Federico, Lichtner, M., Capobianchi, M. R., Nicastri, E., Acinapura, R., Ammassari, A., Capozzi, M., Tebano, G., Lorenzini, P., Von Schloesser, F., Zaccarelli, M., Viviani, F., Sasset, L., Mura, M. S., De Luca, A., Rossetti, B., Caramello, P., Di Perri, G., Orofino, G., Sciandra, M., Bassetti, M., Londero, A., Pellizzer, G., Manfrin, V., Bandera A, Gori A, Sabbatini F, Madeddu G, Bonora S, Libertone R, Mastroianni C, Bonfanti P, Monforte A.D, Cozzi-Lepri A, Giacometti A, Costantini A, Mazzoccato S, Angarano G, Monno L, Santoro C, Maggiolo F, Suardi C, Viale P, Borderi M, Vanino E, Verucchi G, Castelli F, Roldan E.Q, Minardi C, Quirino T, Abeli C, Manconi P.E, Piano P, Vecchiet J, Falasca K, Sighinolfi L, Segala D, Mazzotta F, Lo Caputo S, Cassola G, Viscoli C, Di Biagio A, Alessandrini A, Piscopo R, Mazzarello G, Belvisi V, Caramma I, Chiodera A, Castelli P, Moroni M, Puoti M, Galli M, Lazzarin A, Rizzardini G, Ridolfo A.L., Piolini R, Rusconi S, Balotta C, Castagna A, Marchetti G, Tincati C, Cicconi P, Moioli M.C, Cinque P, Gianotti N, Salpietro S, Galli L, Carenzi L, Iardino R, Tavelli A, Mussini C, Guaraldi G, Marcotullio S, Puzzolante C, Lapadula G, Abrescia N, Chirianni A, Borgia G, Maddaloni A, Gargiulo M, Gentile I, Orlando R, Baldelli F, Francisci D, Parruti G, Ursini T, Magnani G, Ursitti Ma, Cauda R, Antinori A, Andreoni M, Vullo V, Ceccherini-Silberstein F, Cingolani A, Girardi E, D'Avino A, Fanti I, Gallo L, Ippolito G, Perno C.F, Lichtner M, Capobianchi M.R, Nicastri E, Acinapura R, Ammassari A, Capozzi M, Tebano G, Lorenzini P, Von Schloesser F, Zaccarelli M, Viviani F, Sasset L, Mura M.S, De Luca A, Rossetti B, Caramello P, Di Perri G, Orofino G, Sciandra M, Bassetti M, Londero A, Pellizzer G, and Manfrin V.

Subjects
CHRONIC KIDNEY-DISEASE, Genetics and Molecular Biology (all), Male, fumarates, lcsh:Medicine, hiv, HIV Infections, Kidney Function Tests, GLOMERULAR-FILTRATION-RATE, Gastroenterology, Biochemistry, Cohort Studies, chemistry.chemical_compound, MED/17 Malattie infettive, ANTIRETROVIRAL THERAPY, INSUFFICIENCY, Risk Factors, Cardiovascular Disease, HIV Infection, lcsh:Science, Adult, Cardiovascular Diseases, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Italy, Prognosis, Proportional Hazards Models, Disease Progression, Agricultural and Biological Sciences (all), Biochemistry, Genetics and Molecular Biology (all), Medicine (all), fumarate tdf, Multidisciplinary, CYSTATIN C, biology, ASSOCIATION, Adult, Cardiovascular Diseases, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Glomerular Filtration Rate, HIV Infections, Humans, Italy, Kidney Function Tests, Male, Prognosis, Proportional Hazards Models, Risk Factors, CREATININE, Cohort study, Human, Research Article, medicine.medical_specialty, Prognosi, Renal function, HIV-1-INFECTED PATIENTS, NO, Follow-Up Studie, EVENTS, Acquired immunodeficiency syndrome (AIDS), RISK-FACTOR, Internal medicine, Diabetes mellitus, medicine, Risk factor, Creatinine, Kidney Function Test, Proportional hazards model, business.industry, Risk Factor, lcsh:R, medicine.disease, Cystatin C, chemistry, Immunology, biology.protein, Proportional Hazards Model, lcsh:Q, Cohort Studie, business
Abstract

Whilst renal dysfunction, especially mild impairment (602 (mildly impaired). Characteristics of patients were described after stratification in these groups and compared using chi-square test (categorical variables) or Kruskal Wallis test comparing median values. Follow-up accrued from baseline up to the date of the CCVD or AIDS related events or death or last available visit. Kaplan Meier curves were used to estimate the cumulative probability of occurrence of the events over time. Adjusted analysis was performed using a proportional hazards Cox regression model. We included 7,385 patients, observed for a median follow-up of 43 months (inter-quartile range [IQR]: 21-93 months). Over this time, 130 cerebro-cardiovascular events (including 11 deaths due to CCVD) and 311 AIDS-related events (including 45 deaths) were observed. The rate of CCVD events among patients with eGFR >90, 60-89, 90, 60-89

Published
2015

106. Prognostic Value of the Fibrosis-4 Index in Human Immunodeficiency Virus Type-1 Infected Patients Initiating Antiretroviral Therapy with or without Hepatitis C Virus

Author

Mussini C., Lorenzini P., Puoti M., Lichtner M., Lapadula G., Di Giambenedetto S., Antinori A., Madeddu G., Cozzi-Lepri A., D'Arminio Monforte A., De Luca A., Moroni M., Andreoni M., Angarano G., Castelli F., Cauda R., Di Perri G., Galli M., Iardino R., Ippolito G., Lazzarin A., Perno C. F., von Schloesser F., Viale P., Castagna A., Ceccherini-Silber-Stein F., Girardi E., Lo Caputo S., Ammassari A., Balotta C., Bandera A., Bonfanti P., Bonora S., Borderi M., Calcagno A., Calza L., Capobianchi M. R., Ceccherini-Silberstein F., Cingolani A., Cinque P., Di Biagio A., Gianotti N., Gori A., Guaraldi G., Maggiolo F., Marchetti G., Marcotullio S., Monno L., Nozza S., Roldan E. Q., Rossotti R., Rusconi S., Santoro M. M., Saracino A., Zaccarelli M., Fanti I., Galli L., Rodano A., Shanyinde M., Tavelli A., Giacometti A., Costantini A., Mazzoccato S., Santoro C., Suardi C., Vanino E., Verucchi G., Minardi C., Quirino T., Abeli C., Manconi P. E., Piano P., Vecchiet J., Falasca K., Sighinolfi L., Segala D., Mazzotta F., Cassola G., Viscoli C., Alessandrini A., Piscopo R., Mazzarello G., Mastroianni C., Belvisi V., Caramma I., Chiodera A., Castelli A. P., Rizzardini G., Ridolfo A. L., Piolini R., Salpietro S., Carenzi L., Moioli M. C., Tincati C., Puzzolante C., Abrescia N., Chirianni A., Borgia G., Di Martino F., Maddaloni L., Gentile I., Orlando R., Baldelli F., Francisci D., Parruti G., Ursini T., Magnani G., Ursitti M. A., Vullo V., Baldin G., Gallo L., Nicastri E., Acinapura R., Capozzi M., Libertone R., Savinelli S., Cecchetto M., Viviani F., Mura M. S., Rossetti B., Caramello P., Oro-Fino G. C., Sciandra M., Bassetti M., Londero A., Pellizzer G., Manfrin V., Mussini, C, Lorenzini, P, Puoti, M, Lichtner, M, Lapadula, G, Di Giambenedetto, S, Antinori, A, Madeddu, G, Cozzi-Lepri, A, D'Arminio Monforte, A, De Luca, A, Moroni, M, Andreoni, M, Angarano, G, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, C, von Schloesser, F, Viale, P, Castagna, A, Ceccherini-Silber-Stein, F, Girardi, E, Lo Caputo, S, Ammassari, A, Balotta, C, Bandera, A, Bonfanti, P, Bonora, S, Borderi, M, Calcagno, A, Calza, L, Capobianchi, M, Ceccherini-Silberstein, F, Cingolani, A, Cinque, P, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Nozza, S, Roldan, E, Rossotti, R, Rusconi, S, Santoro, M, Saracino, A, Zaccarelli, M, Fanti, I, Galli, L, Rodano, A, Shanyinde, M, Tavelli, A, Giacometti, A, Costantini, A, Mazzoccato, S, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, A, Rizzardini, G, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Borgia, G, Di Martino, F, Maddaloni, L, Gentile, I, Orlando, R, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, Baldin, G, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Savinelli, S, Cecchetto, M, Viviani, F, Mura, M, Rossetti, B, Caramello, P, Oro-Fino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Mussini, Cristina, Lorenzini, Patrizia, Puoti, Massimo, Lichtner, Miriam, Lapadula, Giuseppe, Di Giambenedetto, Simona, Antinori, Andrea, Madeddu, Giordano, Cozzi Lepri, Alessandro, D'Arminio Monforte, Antonella, De Luca, Andrea, Moroni, M., Andreoni, ALESSANDRA MARIA, Angarano, G., Antinori, A., D'Arminio Monforte, A., Castelli, F., Cauda, R., Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Perno, C. F., Von Schloesser, F., Viale, P., Castagna, A., Ceccherini Silberstein, F., Cozzi Lepri, A., Girardi, E., Gentile, Ivan, Borgia, Guglielmo, Lo Caputo, S., Mussini, C., Puoti, M., Andreoni, M., Ammassari, A., Balotta, C., Bandera, A., Bonfanti, Patrizia, Bonora, S., Borderi, M., Calcagno, A., Calza, L., Capobianchi, M. R., Cingolani, A., Cinque, P., De Luca, A., Di Biagio, A., Gianotti, N., Gori, A., Guaraldi, G., Lapadula, G., Lichtner, M., Madeddu, G., Maggiolo, F., Marchetti, G., Marcotullio, S., Monno, L., Nozza, S., Quiros Roldan, E., Rossotti, R., Rusconi, S., Santoro, M. M., Saracino, A., Zaccarelli, M., Fanti, I., Galli, L., Lorenzini, P., Rodano, A., Shanyinde, M., Tavelli, A., C, Mussini, P. Lorenzini, M. Puoti, M. Lichtner, G. Lapadula, S. Di Giambenedetto, A. Antinori, G. Madeddu, A. Cozzi-Lepri, A. d’Arminio Monforte, A. De Luca, ICONA Foundation study group […, P Viale, E Vanino, G Verucchi, …], Cozzi-Lepri, Alessandro, D'arminio Monforte, Antonella, on behalf the ICONA Foundation Study, Grp, and Castagna, Antonella

Subjects
CD4-Positive T-Lymphocytes, Liver Cirrhosis, Male, Genetics and Molecular Biology (all), lcsh:Medicine, HIV Infections, hiv, Hepacivirus, medicine.disease_cause, Biochemistry, MED/17 Malattie infettive, Retrospective Studie, Risk Factors, HIV Infection, Prospective Studies, Viral, Chronic, lcsh:Science, Prospective cohort study, Multidisciplinary, Medicine (all), Adult, Anti-Retroviral Agents, Carcinoma, Hepatocellular, Female, HIV-1, Hepatitis C, Chronic, Humans, Liver, Liver Neoplasms, Middle Aged, Prognosis, RNA, Viral, Retrospective Studies, Viral Load, Agricultural and Biological Sciences (all), Biochemistry, Genetics and Molecular Biology (all), agricultural and biological sciences (all), biochemistry, genetics and molecular biology (all), medicine (all), virus diseases, Hepatitis C, Not available, CD4-Positive T-Lymphocyte, Liver Neoplasm, Hepatocellular carcinoma, Cohort, Viral load, Human, Research Article, Cart, medicine.medical_specialty, Prognosi, Hepatitis C virus, Liver Cirrhosi, Settore MED/17 - MALATTIE INFETTIVE, NO, Internal medicine, medicine, fibrosis, Hepaciviru, business.industry, Proportional hazards model, Risk Factor, lcsh:R, Carcinoma, Retrospective cohort study, Hepatocellular, medicine.disease, Prospective Studie, Immunology, RNA, lcsh:Q, Anti-Retroviral Agent, business
Abstract

Objective: To evaluate the Fibrosis (FIB)-4 index as a predictor of major liver-related events (LRE) and liver-related death (LRD) in human immunodeficiency virus (HIV) type-1 patients initiating combination antiretroviral therapy (cART). Design: Retrospective analysis of a prospective cohort study. Setting: Italian HIV care centers participating to the ICONA Foundation cohort. Participants: Treatment-naive patients enrolled in ICONA were selected who: initiated cART, had hepatitis C virus (HCV) serology results, were HBsAg negative, had an available FIB-4 index at cART start and during follow up. Methods: Cox regression models were used to determine the association of FIB4 with the risk of major LRE (gastrointestinal bleeding, ascites, hepatic encephalopathy, hepato-renal syndrome or hepatocellular carcinoma) or LRD. Results: Three-thousand four-hundred seventy-five patients were enrolled: 73.3% were males, 27.2% HCV seropositive. At baseline (time of cART initiation) their median age was 39 years, had a median CD4+ T cell count of 260 cells/uL, and median HIV RNA 4.9 log copies/mL, 65.9% had a FIB-4 3.25. Over a follow up of 18,662 person-years, 41 events were observed: 25 major LRE and 16 LRD (incidence rate, IR, 2.2 per 1,000 PYFU [95% confidence interval, CI 1.6–3.0]). IR was higher in HCV seropositives as compared to negatives (5.9 vs 0.5 per 1,000 PYFU). Higher baseline FIB-4 category as compared to 3.25: HR 4.25, 1.21–14.92) and time-updated FIB-4 (FIB-4 1.45–3.25: HR 3.40, 1.02–11.40; FIB-4 >3.25: HR 21.24, 6.75–66.84) were independently predictive of major LRE/LRD, after adjusting for HIV- and HCV-related variables, alcohol consumption and type of cART. Conclusions: The FIB-4 index at cART initiation, and its modification over time are risk factors for major LRE or LRD, independently of infection with HCV and could be used to monitor patients on cART.

Published
2015

107. Voltage gating of mechanosensitive PIEZO channels

Author

Moroni, M., Servin-Vences, M.R., Fleischer, R., Sánchez-Carranza, O., and Lewin, G.R.

Subjects
Function and Dysfunction of the Nervous System
Abstract

Mechanosensitive PIEZO ion channels are evolutionarily conserved proteins whose presence is critical for normal physiology in multicellular organisms. Here we show that, in addition to mechanical stimuli, PIEZO channels are also powerfully modulated by voltage and can even switch to a purely voltage-gated mode. Mutations that cause human diseases, such as xerocytosis, profoundly shift voltage sensitivity of PIEZO1 channels toward the resting membrane potential and strongly promote voltage gating. Voltage modulation may be explained by the presence of an inactivation gate in the pore, the opening of which is promoted by outward permeation. Older invertebrate (fly) and vertebrate (fish) PIEZO proteins are also voltage sensitive, but voltage gating is a much more prominent feature of these older channels. We propose that the voltage sensitivity of PIEZO channels is a deep property co-opted to add a regulatory mechanism for PIEZO activation in widely different cellular contexts.

Published
2018

109. Emplacement of the huge Zn-Pb-Ag vein system of Montevecchio, Arburese (SW Sardinia): geological, mineralogical, geothermometric and isotopic inputs towards a new metallogenic model

Author

Moroni, M., Naitza, S., Lattanzi, P., Ruggieri, G., Aquino, A., Caruso, S., and Ferrari, E.

Subjects
Metallogenic model, Sardinia, Arburese, Montevecchio, Zn-Pb-Ag vein system
Abstract

Geological, mineralogical, geothermometric and isotopic inputs towards a new metallogenic model for the emplacement of the huge Zn-Pb-Ag vein system of Montevecchio, Arburese (SW Sardinia).

Published
2018
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110. Il campo filoniano a Ni-Co del Distretto Arburese (Sardegna SW): caratterizzazione geo-giacimentologica e mineralogico-geochimica di una risorsa di interesse strategico

Author

Moroni, M., Naitza, S., Ferrari, E., Magnani, L., Oggiano, G., and Secchi, F.

Subjects
Sardegna, campo filoniano, Distretto Arburese, geo-giacimentologia
Abstract

La caratterizzazione geo-giacimentologica e mineralogico-geochimica di una risorsa di interesse strategico per il campo filoniano a Ni-Co del Distretto Arburese (Sardegna SW).

Published
2018

111. Mechano-sensitization of mammalian neuronal networks through expression of the bacterial large-conductance mechanosensitive ion channel

Author

Soloperto A, Boccaccio A, Contestabile A, Moroni M, Hallinan GI, Palazzolo G, Chad J, Deinhardt K, Carugo D, and Difato F

Subjects
Mechanobiology, Neuronal mechanosensitization, Nanopore engineering, Exclusively mechanosensitive ion channel, MscL
Abstract

Development of remote stimulation techniques for neuronal tissues represents a challenging goal. Among the potential methods, mechanical stimuli are the most promising vectors to convey information non-invasively into intact brain tissue. In this context, selective mechano-sensitization of neuronal circuits would pave the way to develop a new cell-type-specific stimulation approach. We report here, for the first time, the development and characterization of mechano-sensitized neuronal networks through the heterologous expression of an engineered bacterial large-conductance mechanosensitive ion channel (MscL). The neuronal functional expression of the MscL was validated through patch-clamp recordings upon application of calibrated suction pressures. Moreover, we verified the effective development of in-vitro neuronal networks expressing the engineered MscL in terms of cell survival, number of synaptic puncta and spontaneous network activity. The pure mechanosensitivity of the engineered MscL, with its wide genetic modification library, may represent a versatile tool to further develop a mechano-genetic approach.

Published
2018

112. The Ni-Co-As-Ag-Bi-rich hydrothermal vein ores of the Arburese district (SW Sardinia, Italy): mineralogical and geochemical characterization of possible sources for critical metals

Author

Moroni, M., Naitza, S., Magnani, L., Ferrari, E., Oggiano, G., and Secchi, F.

Subjects
Arburese district, critical metals, ores, Sardinia, hydrothermal vein
Abstract

Mineralogical and geochemical characterization of possible sources for critical metals in the Ni-Co-As-Ag-Bi-rich hydrothermal vein ores of the Arburese district (SW Sardinia, Italy)

Published
2018
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118. Longitudinal analysis of HIV-1 coreceptor tropism by single and triplicate HIV-1 RNA and DNA sequencing in patients undergoing successful first-line antiretroviral therapy

Author

Meini, G., Rossetti, B., Bianco, C., Ceccherini-Silberstein, F., Di Giambenedetto, S., Sighinolfi, L., Monno, L., Castagna, A., Rozera, G., D'Arminio Monforte, A., Zazzi, M., De Luca, A., Moroni, M., Angarano, G., Antinori, A., Armignacco, O., d'Arminio Monforte, A., Castelli, F., Cauda, R., Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Perno, C. F., von Schloesser, F., Viale, P., Cozzi-Lepri, A., Girardi, E., Lo Caputo, S., Mussini, C., Puoti, M., Andreoni, M., Ammassari, A., Balotta, C., Bonfanti, P., Bonora, S., Borderi, M., Capobianchi, M. R., Cingolani, A., Cinque, P., Di Biagio, A., Gianotti, N., Gori, A., Guaraldi, G., Lapadula, G., Lichtner, M., Madeddu, G., Maggiolo, F., Marchetti, G., Marcotullio, S., Quiros Roldan, E., Rusconi, S., Cicconi, P., Fanti, I., Formenti, T., Galli, L., Lorenzini, P., Giacometti, A., Costantini, A., Santoro, C., Suardi, C., Vanino, E., Verucchi, G., Minardi, C., Quirino, T., Abeli, C., Manconi, P. E., Piano, P., Vecchiet, J., Falasca, K., Segala, D., Mazzotta, F., Cassola, G., Viscoli, G., Alessandrini, A., Piscopo, R., Mazzarello, G., Mastroianni, C., Belvisi, V., Caramma, I., Castelli, A. P., Rizzardini, G., Ridolfo, A. L., Piolini, R., Salpietro, S., Carenzi, L., Moioli, M. C., Puzzolante, C., Abrescia, N., Chirianni, A., Guida, M. G., Gargiulo, M., Baldelli, F., Francisci, D., Parruti, G., Ursini, T., Magnani, G., Ursitti, M. A., Vullo, V., d'Avino, A., Gallo, L., Nicastri, E., Acinapura, R., Capozzi, M., Libertone, R., Tebano, G., Cattelan, A., Mura, M. S., Caramello, P., Orofino, G. C., Sciandra, M., Pellizzer, G., Manfrin, V., Meini, Genny, Rossetti, Barbara, Bianco, Claudia, ICONA Fdn, Grp, Castagna, Antonella, Meini, G, Rossetti, B, Bianco, C, Ceccherini Silberstein, F, Di Giambenedetto, S, Sighinolfi, L, Monno, L, Castagna, A, Rozera, G, D'arminio Monforte, A, Zazzi, M, De Luca, A, Moroni, M, Armignacco, O, Iardino, R, Ippolito, G, Perno, C, Von Schloesser, F, Cozzi Lepri, A, Girardi, E, Balotta, C, Borderi, M, Capobianchi, M, Cinque, P, Di Biagio, A, Gianotti, N, Guaraldi, G, Lichtner, M, Marcotullio, S, Rusconi, S, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantini, A, Angarano, G, Santoro, C, Maggiolo, F, Suardi, C, Viale, P, Vanino, E, Verucchi, G, Castelli, F, Quiros Roldan, E, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Segala, D, Mazzotta, F, Lo Caputo, S, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Bonfanti, P, Caramma, I, Castelli, A, Galli, M, Lazzarin, A, Rizzardini, G, Puoti, M, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Cicconi, P, Marchetti, G, Mussini, C, Puzzolante, C, Gori, A, Lapadula, G, Abrescia, N, Chirianni, A, Guida, M, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Cauda, R, Andreoni, M, Antinori, A, Vullo, V, Cingolani, A, D'Avino, A, Ammassari, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Mura, M, Madeddu, G, Caramello, P, Di Perri, G, Orofino, G, Bonora, S, Sciandra, M, Pellizzer, G, and Manfrin, V

Subjects
Male, viruses, Salvage therapy, HIV Infections, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Genotype interpretation, gp120, HIV type 1, V3, Adult, Anti-Retroviral Agents, Antiretroviral Therapy, Highly Active, DNA, Viral, Female, Genotype, HIV-1, Humans, RNA, Viral, Sequence Analysis, DNA, Viral Tropism, Pharmacology, Pharmacology (medical), Infectious Diseases, Medicine (all), HIV Infection, Viral, 030212 general & internal medicine, Original Research, 0303 health sciences, tropism, virus diseases, Settore MED/07 - Microbiologia e Microbiologia Clinica, 3. Good health, genotype interpretation, Sequence Analysis, Human, Microbiology (medical), antiretroviral therapy, Antiretroviral Therapy, Viremia, Infectious Disease, CCR5 receptor antagonist, Biology, HIV infection, Settore MED/17 - MALATTIE INFETTIVE, NO, 03 medical and health sciences, medicine, Highly Active, Tropism, Maraviroc, 030306 microbiology, RNA, DNA, medicine.disease, Virology, chemistry, Immunology, Tissue tropism, Anti-Retroviral Agent, Cohort Studie
Abstract

Objectives: Maraviroc has been shown to be effective in patients harbouring CCR5-tropic HIV-1. While this CCR5 antagonist has initially been used in salvage therapy, its excellent safety profile makes it ideal for antiretroviral treatment simplification strategies in patients with suppressed plasma viraemia. The aim of this study was to compare HIV-1 tropism as detected in baseline plasma RNA and peripheral blood mononuclear cell (PBMC) DNA prior to first-line therapy and to analyse tropism evolution while on successful treatment. Methods: HIV-1 tropism was determined using triplicate genotypic testing combined with geno2pheno[coreceptor] analysis at a 10% false positive rate in 42 patients. Paired pre-treatment plasma RNA and PBMC DNA and two subsequent PBMC DNA samples (the first obtained after reaching undetectable plasma HIV-1 RNA and the second after at least 2 years of suppression of plasma viraemia) were evaluated. Results: Coreceptor tropism was completely concordant in paired pre-treatment RNA and DNA, with 26.2% of HIV-1 sequences predicted to be non-CCR5-tropic. During follow-up, coreceptor tropism switches were detected in 4 (9.5%) patients without any preferential direction. Although false positive rate discrepancies within triplicates were common, the rate of discordance of coreceptor tropism assignment among triplicate results in this mostly CCR5-tropic dataset was only 2.1%, questioning the added value of triplicate testing compared with single testing. Conclusions: HIV-1 coreceptor tropism changes during virologically successful first-line treatment are infrequent. HIV-1 DNA analysis may thus support the choice of a CCR5 antagonist in treatment switch strategies; however, maraviroc treatment outcome data are required to confirm this option. © The Author 2013. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved

Published
2013
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121. Long-term durability of tenofovir-based antiretroviral therapy In relation to the Co-administration of other drug classes in routine clinical practice

Author

Costarelli, Silvia, Cozzi-Lepri, Alessandro, Lapadula, Giuseppe, Bonora, Stefano, Madeddu, Giordano, Maggiolo, Franco, Antinori, Andrea, Galli, Massimo, Di Perri, Giovanni, Viale, Pierluigi, D'Arminio Monforte, Antonella, Gori, Andrea, Moroni, M., Andreoni, M., Angarano, G., Castelli, F., Cauda, R., Iardino, R., Ippolito, G., Lazzarin, A., Perno, C. F., Von Schloesser, F., Castagna, A., Ceccherini-Silberstein, F., Girardi, E., Lo Caputo, S., Mussini, C., Puoti, M., Ammassari, A., Balotta, C., Bonfanti, P., Borderi, M., Capobianchi, M. R., Cingolani, A., Cinque, P., De Luca, A., Di Biagio, A., Gianotti, N., Guaraldi, G., Lichtner, M., Marchetti, G., Marcotullio, S., Monno, L., Quiros Roldan, E., Rusconi, S., Saracino, A., Cicconi, P., Fanti, I., Galli, L., Lorenzini, P., Tavelli, A., Giacometti, A., Costantini, A., Mazzoccato, S., Santoro, C., Suardi, C., Vanino, E., Verucchi, G., Minardi, C., Quirino, T., Abeli, C., Manconi, P. E., Piano, P., Vecchiet, J., Falasca, K., Sighinolfi, L., Segala, D., Mazzotta, F., Cassola, G., Viscoli, C., Alessandrini, A., Piscopo, R., Mazzarello, G., Mastroianni, C., Belvisi, V., Caramma, I., Chiodera, A., Castelli, A. P., Rizzardini, G., Ridolfo, A. L., Piolini, R., Salpietro, S., Carenzi, L., Moioli, M. C., Tincati, C., Puzzolante, C., Abrescia, N., Chirianni, A., Guida, M. G., Gargiulo, M., Baldelli, F., Francisci, D., Parruti, G., Ursini, T., Magnani, G., Ursitti, M. A., Vullo, V., D'Avino, A., Gallo, L., Nicastri, E., Acinapura, R., Capozzi, M., Libertone, R., Tebano, G., Cattelan, A., Sasset, L., Mura, M. S., Rossetti, B., Caramello, P., Orofino, G. C., Sciandra, M., Bassetti, M., Londero, A., Pellizzer, G., Manfrin, V., Costarelli, S, Cozzi Lepri, A, Lapadula, G, Bonora, S, Madeddu, G, Maggiolo, F, Antinori, A, Galli, M, Di Perri, G, Viale, P, D'Arminio Monforte, A, Gori, A, Moroni, M, Andreoni, M, Angarano, G, Castelli, F, Cauda, R, Iardino, R, Ippolito, G, Lazzarin, A, Perno, C, Von Schloesser, F, Castagna, A, Ceccherini Silberstein, F, Girardi, E, Lo Caputo, S, Mussini, C, Puoti, M, Ammassari, A, Balotta, C, Bonfanti, P, Borderi, M, Capobianchi, M, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gianotti, N, Guaraldi, G, Lichtner, M, Marchetti, G, Marcotullio, S, Monno, L, Quiros Roldan, E, Rusconi, S, Saracino, A, Cicconi, P, Fanti, I, Galli, L, Lorenzini, P, Tavelli, A, Giacometti, A, Costantini, A, Mazzoccato, S, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, A, Rizzardini, G, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, M, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, D'Avino, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Sasset, L, Mura, M, Rossetti, B, Caramello, P, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Cozzi-Lepri, A, and ICONA Foundation Study, Group

Subjects
0301 basic medicine, Male, Genetics and Molecular Biology (all), Medical Doctors, Health Care Providers, Adult, Anti-HIV Agents, Drug Therapy, Combination, Female, HIV Infections, HIV Protease Inhibitors, Humans, Middle Aged, Reverse Transcriptase Inhibitors, Ritonavir, Tenofovir, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), lcsh:Medicine, Pharmacology, Toxicology, Pathology and Laboratory Medicine, Biochemistry, MED/17 Malattie infettive, 0302 clinical medicine, Medicine and Health Sciences, Medicine, HIV Infection, Public and Occupational Health, 030212 general & internal medicine, Enzyme Inhibitors, lcsh:Science, media_common, Multidisciplinary, Antimicrobials, Pharmaceutics, Medicine (all), virus diseases, Drugs, Antiretrovirals, HIV diagnosis and management, Antivirals, Vaccination and Immunization, Reverse Transcriptase Inhibitor, 3. Good health, Professions, Combination, Human, medicine.drug, Research Article, Drug, medicine.medical_specialty, Long term durability, media_common.quotation_subject, Immunology, Antiretroviral Therapy, Microbiology, NO, 03 medical and health sciences, Pharmacotherapy, Antiviral Therapy, Drug Therapy, Internal medicine, Microbial Control, Virology, Physicians, Protease Inhibitors, HIV Protease Inhibitor, Toxicity, business.industry, lcsh:R, Anti-HIV Agent, Biology and Life Sciences, Adult, Anti-HIV Agents, Drug Therapy, Combination, Female, HIV Infections, HIV Protease Inhibitors, Humans, Male, Middle Aged, Reverse Transcriptase Inhibitors, Ritonavir, Tenofovir, 030112 virology, Antiretroviral therapy, Diagnostic medicine, Discontinuation, Clinical trial, Health Care, People and Places, Enzymology, lcsh:Q, Population Groupings, Preventive Medicine, business
Abstract

BACKGROUND: In clinical trials, toxicity leading to tenofovir disoproxil fumarate (TDF) discontinuation is rare (3% by 2 years); however in clinical practice it seems to be higher, particularly when TDF is co-administered with ritonavir-boosted protease inhibitors (PI/r). Aims of this study were to assess the rate of TDF discontinuations in clinical practice and to identify factors associated with the risk of stopping TDF. METHODS: All antiretroviral treatment (ART)-naive patients initiating a TDF-based regimen were selected from the ICONA Foundation Study cohort. The primary outcome was TDF discontinuation regardless of the reason; secondary outcome measures were TDF discontinuation due to toxicity and selective TDF discontinuation (that is, TDF discontinuation or substitution, maintaining unchanged the remaining antiretroviral treatment). RESULTS: 3,618 ART-naïve patients were included: 54% started a PI/r-based and 46% a NNRTI-based based regimen. Two-hundred-seventy-seven patients discontinued TDF and reintroduced ART within 30 days without TDF. The probability of TDF discontinuation regardless of the reason was of 7.4% (95%CI:6.4-8.5) by 2 years and 14.1% (95%CI:12.2-16.1) by 5 years. The 5-year KM estimates in the PI/r vs. NNRTI group were 20.4% vs. 7.6%, respectively (log-rank p = 0.0001), for the outcome of stopping regardless of the reason, and 10.7% vs. 4.7% (p = 0.0001) for discontinuation due to toxicity. PI/r use and lower eGFR were associated with an increased risk of discontinuing TDF. CONCLUSION: In our cohort, the frequency of TDF discontinuations was higher than that observed in clinical trials. Co-administration of TDF with PI/r was associated with an increased rate of TDF discontinuations. Further studies are needed to clarify the mechanisms that might have led to this outcome.

Published
2016

122. Competing effects of Mn and y doping on the low-energy excitations and phase diagram of La1-y YyFe1-xMnxAsO0.89 F0.11 iron-based superconductors

Author

Moroni, M., Lamura, G., Shiroka, T., De Renzi, R., Kappenberger, R., Afrassa, M. A., Wurmehl, S., Wolter, A. U. B., Büchner, B., Carretta, P., SANNA, SAMUELE, Moroni, M., Sanna, S., Lamura, G., Shiroka, T., De Renzi, R., Kappenberger, R., Afrassa, M.A., Wurmehl, S., Wolter, A.U.B., Büchner, B., and Carretta, P.

Subjects
nuclear magnetic resonance, Condensed Matter::Superconductivity, Electronic, Optical and Magnetic Material, superconductivity, magnetism, Condensed Matter Physic
Abstract

Muon spin rotation (μSR) and F19 nuclear magnetic resonance (NMR) measurements were performed to investigate the effect of Mn for Fe substitutions in La1-yYyFe1-xMnxAsO0.89F0.11 superconductors. While for y=0 a very low critical concentration of Mn (x=0.2%) is needed to quench superconductivity, as y increases the negative chemical pressure introduced by Y for La substitution stabilizes superconductivity and for y=20% it is suppressed at Mn contents an order of magnitude larger. A magnetic phase arises once superconductivity is suppressed both for y=0 and for y=20%. Low-energy spin fluctuations give rise to a peak in F19 NMR 1/T1 with an onset well above the superconducting transition temperature and whose magnitude increases with x. Also the static magnetic correlations probed by F19 NMR linewidth measurements show a marked increase with Mn content. The disruption of superconductivity and the onset of the magnetic ground state are discussed in the light of the proximity of LaFeAsO0.89F0.11 to a quantum critical point.

Published
2016

123. Increased risk of virologic failure to the first antiretroviral regimen in HIV-infected migrants compared to natives: Data from the ICONA cohort

Author

Saracino, A, Lorenzini, P, Lo Caputo, S, Girardi, E, Castelli, F, Bonfanti, P, Rusconi, S, Caramello, P, Abrescia, N, Mussini, C, Monno, L, d'Arminio Monforte, A, Moroni, M, Andreoni, M, Angarano, G, Antinori, A, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, C, von Schloesser, F, P. , V, Castagna, A, Ceccherini Silberstein, F, Cozzi Lepri, A, Puoti, M, Ammassari, A, Balotta, C, Bonora, S, Borderi, M, Capobianchi, M, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gianotti, N, Guaraldi, G, Lichtner, M, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Quiros Roldan, E, A. , S, Cicconi, P, Fanti, I, Galli, L, Shanyinda, M, Tavelli, A, Giacometti, A, Costantini, A, Mazzoccato, S, Santoro, C, Suardi, C, Viale, P, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, A, Rizzardini, G, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Tincati, C, Puzzolante, C, Gori, A, Lapadula, G, Chirianni, A, Borgia, G, Guida, M, Gargiulo, M, Gentile, I, Orlando, R, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, D'Avino, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Zaccarelli, M, Viviani, F, Sasset, L, Mura, M, Rossetti, B, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V., GORI, ANDREA, LAPADULA, GIUSEPPE, Saracino, A, Lorenzini, P, Lo Caputo, S, Girardi, E, Castelli, F, Bonfanti, P, Rusconi, S, Caramello, P, Abrescia, N, Mussini, C, Monno, L, d'Arminio Monforte, A, for the ICONA Foundation Study, Group, Castagna, A, Lazzarin, A, Moroni, M, Andreoni, M, Angarano, G, Antinori, A, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Perno, C, von Schloesser, F, P., V, Ceccherini Silberstein, F, Cozzi Lepri, A, Puoti, M, Ammassari, A, Balotta, C, Bonora, S, Borderi, M, Capobianchi, M, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Lapadula, G, Lichtner, M, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Quiros Roldan, E, A., S, Cicconi, P, Fanti, I, Galli, L, Shanyinda, M, Tavelli, A, Giacometti, A, Costantini, A, Mazzoccato, S, Santoro, C, Suardi, C, Viale, P, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, A, Rizzardini, G, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Tincati, C, Puzzolante, C, Chirianni, A, Borgia, G, Guida, M, Gargiulo, M, Gentile, I, Orlando, R, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, D'Avino, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Zaccarelli, M, Viviani, F, Sasset, L, Mura, M, Rossetti, B, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Saracino, A., Lorenzini, P., Lo Caputo, S., Girardi, E., Castelli, F., Bonfanti, P., Rusconi, S., Caramello, P., Abrescia, N., Mussini, C., Gentile, Ivan, Borgia, Guglielmo, Orlando, Raffaele, Et, A, Monno, L., and d'Arminio Monforte, A.

Subjects
0301 basic medicine, Male, Pediatrics, HIV Infections, Comorbidity, Kaplan-Meier Estimate, migrants, Rate ratio, 0302 clinical medicine, Antiretroviral Therapy, Highly Active, HIV Infection, 030212 general & internal medicine, Treatment Failure, Transients and Migrants, virological failure, Incidence (epidemiology), General Medicine, Middle Aged, Viral Load, Antiretroviral therapy, Virologic failure, Treatment Outcome, Infectious Diseases, Italy, Cohort, Female, HIV, ICONA, Migrants, Adult, Anti-HIV Agents, CD4 Lymphocyte Count, HIV-1, Humans, Risk, Human, Microbiology (medical), medicine.medical_specialty, 030106 microbiology, antiretroviral therapy, Settore MED/17 - MALATTIE INFETTIVE, NO, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Transients and Migrant, medicine, Highly Active, business.industry, Migrant, Anti-HIV Agent, Odds ratio, medicine.disease, Confidence interval, Discontinuation, Regimen, business
Abstract

Migrant and Italian HIV-infected patients (n = 5773) enrolled in the ICONA cohort in 2004-2014 were compared for disparities in access to an initial antiretroviral regimen and/or risk of virologic failure (VF), and determinants of failure were evaluated. Variables associated with initiating antiretroviral therapy (ART) were analysed. Primary endpoint was time to failure after at least 6 months of ART and was defined as: VF, first of two consecutive virus loads (VL) >200 copies/mL; treatment discontinuation (TD) for any reason; and treatment failure as confirmed VL >200 copies/mL or TD. A Poisson multivariable analysis was performed to control for confounders. Migrants presented significantly lower CD4 counts and more frequent AIDS events at baseline. When adjusting for baseline confounders, migrants presented a lower likelihood to begin ART (odds ratio 0.80, 95% confidence interval (CI) 0.67-0.95, p 0.012). After initiating ART, the incidence VF rate was 6.4 per 100 person-years (95% CI 4.8-8.5) in migrants and 2.7 in natives (95% CI 2.2-3.3). Multivariable analysis confirmed that migrants had a higher risk of VF (incidence rate ratio 1.90, 95% CI 1.25-2.91, p 0.003) and treatment failure (incidence rate ratio 1.16, 95% CI 1.01-1.33, p 0.031), with no differences for TD. Among migrants, variables associated with VF were age, unemployment and use of a boosted protease inhibitor-based regimen versus nonnucleoside reverse transcriptase inhibitors. Despite the use of more potent and safer drugs in the last 10 years, and even in a universal health care setting, migrants living with HIV still present barriers to initiating ART and an increased risk of VF compared to natives.

Published
2016

124. Ichthyosaurian palaeopathology : evidence of injury and disease in fossil 'fish lizards'

Author

Pardo-Perez, J. M., Kear, Benjamin P., Gomez, M., Moroni, M., Maxwell, E. E., Pardo-Perez, J. M., Kear, Benjamin P., Gomez, M., Moroni, M., and Maxwell, E. E.

Abstract

The documented record of ichthyosaurian paleopathologies reveals an array of injury-related bone modifications and instances of disease evidenced through multiple clades, skeletal regions and body-size classes from the Middle Triassic to middle Cretaceous. Examples include traumatic injuries, as well as a high incidence of articular diseases, including avascular necrosis. Forelimb pathologies are particularly abundant (65% of total reported), and the glenoid region seems to have been especially prone to articular disease. In contrast, pathologies affecting the vertebral column are comparatively underrepresented (6% of reported pathologies). Also notable is the disproportionate commonality of osteopathologies in ichthyosaurian taxa between 2 and 6m in length (54%), as opposed to demonstrably larger (31%) or smaller bodied (15%) species. Furthermore, osteopathologies are almost exclusively described from skeletally mature individuals, and are best known from taxa of Jurassic age (78%), versus those from the Triassic (15%) or Cretaceous (7%); this likely reflects biases in the ichthyosaurian fossil record through time. Ichthyosaurs evince remarkable similarities in the types of observed skeletal damage relative to other ecologically similar marine amniotes - especially cetaceans and mosasaurid squamates, all of which potentially exhibited equivalent palaeoecological and/or behavioural adaptations for life in aqueous environments. Notably, however, the unusually low frequency of vertebral pathologies in ichthyosaurs is peculiar, and requires further investigation to establish significance.

Published
2018
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127. Cytomegalovirus coinfection is associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients

Author

Moroni, M, Angarano, G, Antinori, A, Armignacco, O, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, C, Von Schloesser, F, Viale, P, Castagna, A, Ceccherini-Silberstein, F, Cozzi-Lepri, A, Girardi, E, Caputo, S, Mussini, C, Puoti, M, Andreoni, M, Ammassari, A, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, M, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Lapadula, G, Lichtner, M, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Roldan, E, Rusconi, S, Fanti, I, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantini, A, Carrisa, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Castelli, A, Rizzardini, G, Monforte, A, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Cicconi, P, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, M, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, D'Avino, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Moroni M., Angarano G., Antinori A., Armignacco O., Castelli F., Cauda R., Di Perri G., Galli M., Iardino R., Ippolito G., Lazzarin A., Perno C. F., Von Schloesser F., Viale P., Castagna A., Ceccherini-Silberstein F., Cozzi-Lepri A., Girardi E., Caputo S. L., Mussini C., Puoti M., Andreoni M., Ammassari A., Balotta C., Bonfanti P., Bonora S., Borderi M., Capobianchi M. R., Cingolani A., Cinque P., De Luca A., Di Biagio A., Gianotti N., Gori A., Guaraldi G., Lapadula G., Lichtner M., Madeddu G., Maggiolo F., Marchetti G., Marcotullio S., Monno L., Roldan E. Q., Rusconi S., Fanti I., Formenti T., Galli L., Lorenzini P., Giacometti A., Costantini A., Carrisa C., Suardi C., Vanino E., Verucchi G., Minardi C., Quirino T., Abeli C., Manconi P. E., Piano P., Vecchiet J., Falasca K., Sighinolfi L., Segala D., Mazzotta F., Cassola G., Viscoli G., Alessandrini A., Piscopo R., Mazzarello G., Mastroianni C., Belvisi V., Caramma I., Castelli A. P., Rizzardini G., Monforte A. D. a., Ridolfo A. L., Piolini R., Salpietro S., Carenzi L., Moioli M., Cicconi P., Puzzolante C., Abrescia N., Chirianni A., Guida M. G., Gargiulo M., Baldelli F., Francisci D., Parruti G., Ursini T., Magnani G., Ursitti M. A., Vullo V., D'Avino A., Gallo L., Nicastri E., Acinapura R., Capozzi M., Libertone R., Tebano G., Moroni, M, Angarano, G, Antinori, A, Armignacco, O, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, C, Von Schloesser, F, Viale, P, Castagna, A, Ceccherini-Silberstein, F, Cozzi-Lepri, A, Girardi, E, Caputo, S, Mussini, C, Puoti, M, Andreoni, M, Ammassari, A, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, M, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Lapadula, G, Lichtner, M, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Roldan, E, Rusconi, S, Fanti, I, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantini, A, Carrisa, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Castelli, A, Rizzardini, G, Monforte, A, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Cicconi, P, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, M, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, D'Avino, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Moroni M., Angarano G., Antinori A., Armignacco O., Castelli F., Cauda R., Di Perri G., Galli M., Iardino R., Ippolito G., Lazzarin A., Perno C. F., Von Schloesser F., Viale P., Castagna A., Ceccherini-Silberstein F., Cozzi-Lepri A., Girardi E., Caputo S. L., Mussini C., Puoti M., Andreoni M., Ammassari A., Balotta C., Bonfanti P., Bonora S., Borderi M., Capobianchi M. R., Cingolani A., Cinque P., De Luca A., Di Biagio A., Gianotti N., Gori A., Guaraldi G., Lapadula G., Lichtner M., Madeddu G., Maggiolo F., Marchetti G., Marcotullio S., Monno L., Roldan E. Q., Rusconi S., Fanti I., Formenti T., Galli L., Lorenzini P., Giacometti A., Costantini A., Carrisa C., Suardi C., Vanino E., Verucchi G., Minardi C., Quirino T., Abeli C., Manconi P. E., Piano P., Vecchiet J., Falasca K., Sighinolfi L., Segala D., Mazzotta F., Cassola G., Viscoli G., Alessandrini A., Piscopo R., Mazzarello G., Mastroianni C., Belvisi V., Caramma I., Castelli A. P., Rizzardini G., Monforte A. D. a., Ridolfo A. L., Piolini R., Salpietro S., Carenzi L., Moioli M., Cicconi P., Puzzolante C., Abrescia N., Chirianni A., Guida M. G., Gargiulo M., Baldelli F., Francisci D., Parruti G., Ursini T., Magnani G., Ursitti M. A., Vullo V., D'Avino A., Gallo L., Nicastri E., Acinapura R., Capozzi M., Libertone R., and Tebano G.

Abstract

Background. Chronic cytomegalovirus (CMV) infection has been associated with immunosenescence and immunoactivation in the general population. In human immunodeficiency virus type 1 (HIV-1)-infected people, CMV coinfection, in addition to residual HIV replication and microbial translocation, has been proposed as a key factor in sustaining immune activation, even in individuals with a controlled HIV load.Methods. Patients from the ICONA Study with at least 1 CMV immunoglobulin G (IgG) test available without active CMV disease were included in the analysis. AIDS-defining event or AIDS-related death and severe non-AIDS-defining event or non-AIDS-related death were taken as clinical progression end points. Independent predictors of CMV were identified by multivariable logistic regression. Probabilities of reaching the end points were estimated by survival analyses.Results. A total of 6111 subjects were included, of whom 5119 (83.3%) were CMV IgG positive at baseline. Patients with CMV IgG positivity at baseline were more likely to develop a severe non-AIDS-defining event/non-AIDS-related death (adjusted hazard ratio [HR], 1.53 [95% confidence interval {CI}, 1.08-2.16]. In particular, CMV seropositivity was an independent risk factor for cardiovascular and cerebrovascular diseases (adjusted HR, 2.27 [95% CI, .97-5.32]).Conclusions. In our study population, CMV/HIV coinfection was associated with the risk of severe non-AIDS-defining events/non-AIDS-related death, especially with cardiovascular and cerebrovascular events, independently of other prognostic factors. This finding supports a potential independent role of CMV coinfection in vascular/degenerative organ disorders in HIV-infected subjects.

Published
2015

128. Prognostic Value of the Fibrosis-4 Index in Human Immunodeficiency Virus Type-1 Infected Patients Initiating Antiretroviral Therapy with or without Hepatitis C Virus

Author

Mussini, C, Lorenzini, P, Puoti, M, Lichtner, M, Lapadula, G, Di Giambenedetto, S, Antinori, A, Madeddu, G, Cozzi-Lepri, A, D'Arminio Monforte, A, De Luca, A, Moroni, M, Andreoni, M, Angarano, G, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, C, von Schloesser, F, Viale, P, Castagna, A, Ceccherini-Silber-Stein, F, Girardi, E, Lo Caputo, S, Ammassari, A, Balotta, C, Bandera, A, Bonfanti, P, Bonora, S, Borderi, M, Calcagno, A, Calza, L, Capobianchi, M, Ceccherini-Silberstein, F, Cingolani, A, Cinque, P, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Nozza, S, Roldan, E, Rossotti, R, Rusconi, S, Santoro, M, Saracino, A, Zaccarelli, M, Fanti, I, Galli, L, Rodano, A, Shanyinde, M, Tavelli, A, Giacometti, A, Costantini, A, Mazzoccato, S, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, A, Rizzardini, G, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Borgia, G, Di Martino, F, Maddaloni, L, Gentile, I, Orlando, R, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, Baldin, G, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Savinelli, S, Cecchetto, M, Viviani, F, Mura, M, Rossetti, B, Caramello, P, Oro-Fino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Mussini C., Lorenzini P., Puoti M., Lichtner M., Lapadula G., Di Giambenedetto S., Antinori A., Madeddu G., Cozzi-Lepri A., D'Arminio Monforte A., De Luca A., Moroni M., Andreoni M., Angarano G., Castelli F., Cauda R., Di Perri G., Galli M., Iardino R., Ippolito G., Lazzarin A., Perno C. F., von Schloesser F., Viale P., Castagna A., Ceccherini-Silber-Stein F., Girardi E., Lo Caputo S., Ammassari A., Balotta C., Bandera A., Bonfanti P., Bonora S., Borderi M., Calcagno A., Calza L., Capobianchi M. R., Ceccherini-Silberstein F., Cingolani A., Cinque P., Di Biagio A., Gianotti N., Gori A., Guaraldi G., Maggiolo F., Marchetti G., Marcotullio S., Monno L., Nozza S., Roldan E. Q., Rossotti R., Rusconi S., Santoro M. M., Saracino A., Zaccarelli M., Fanti I., Galli L., Rodano A., Shanyinde M., Tavelli A., Giacometti A., Costantini A., Mazzoccato S., Santoro C., Suardi C., Vanino E., Verucchi G., Minardi C., Quirino T., Abeli C., Manconi P. E., Piano P., Vecchiet J., Falasca K., Sighinolfi L., Segala D., Mazzotta F., Cassola G., Viscoli C., Alessandrini A., Piscopo R., Mazzarello G., Mastroianni C., Belvisi V., Caramma I., Chiodera A., Castelli A. P., Rizzardini G., Ridolfo A. L., Piolini R., Salpietro S., Carenzi L., Moioli M. C., Tincati C., Puzzolante C., Abrescia N., Chirianni A., Borgia G., Di Martino F., Maddaloni L., Gentile I., Orlando R., Baldelli F., Francisci D., Parruti G., Ursini T., Magnani G., Ursitti M. A., Vullo V., Baldin G., Gallo L., Nicastri E., Acinapura R., Capozzi M., Libertone R., Savinelli S., Cecchetto M., Viviani F., Mura M. S., Rossetti B., Caramello P., Oro-Fino G. C., Sciandra M., Bassetti M., Londero A., Pellizzer G., Manfrin V., Mussini, C, Lorenzini, P, Puoti, M, Lichtner, M, Lapadula, G, Di Giambenedetto, S, Antinori, A, Madeddu, G, Cozzi-Lepri, A, D'Arminio Monforte, A, De Luca, A, Moroni, M, Andreoni, M, Angarano, G, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, C, von Schloesser, F, Viale, P, Castagna, A, Ceccherini-Silber-Stein, F, Girardi, E, Lo Caputo, S, Ammassari, A, Balotta, C, Bandera, A, Bonfanti, P, Bonora, S, Borderi, M, Calcagno, A, Calza, L, Capobianchi, M, Ceccherini-Silberstein, F, Cingolani, A, Cinque, P, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Nozza, S, Roldan, E, Rossotti, R, Rusconi, S, Santoro, M, Saracino, A, Zaccarelli, M, Fanti, I, Galli, L, Rodano, A, Shanyinde, M, Tavelli, A, Giacometti, A, Costantini, A, Mazzoccato, S, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, A, Rizzardini, G, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Borgia, G, Di Martino, F, Maddaloni, L, Gentile, I, Orlando, R, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, Baldin, G, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Savinelli, S, Cecchetto, M, Viviani, F, Mura, M, Rossetti, B, Caramello, P, Oro-Fino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Mussini C., Lorenzini P., Puoti M., Lichtner M., Lapadula G., Di Giambenedetto S., Antinori A., Madeddu G., Cozzi-Lepri A., D'Arminio Monforte A., De Luca A., Moroni M., Andreoni M., Angarano G., Castelli F., Cauda R., Di Perri G., Galli M., Iardino R., Ippolito G., Lazzarin A., Perno C. F., von Schloesser F., Viale P., Castagna A., Ceccherini-Silber-Stein F., Girardi E., Lo Caputo S., Ammassari A., Balotta C., Bandera A., Bonfanti P., Bonora S., Borderi M., Calcagno A., Calza L., Capobianchi M. R., Ceccherini-Silberstein F., Cingolani A., Cinque P., Di Biagio A., Gianotti N., Gori A., Guaraldi G., Maggiolo F., Marchetti G., Marcotullio S., Monno L., Nozza S., Roldan E. Q., Rossotti R., Rusconi S., Santoro M. M., Saracino A., Zaccarelli M., Fanti I., Galli L., Rodano A., Shanyinde M., Tavelli A., Giacometti A., Costantini A., Mazzoccato S., Santoro C., Suardi C., Vanino E., Verucchi G., Minardi C., Quirino T., Abeli C., Manconi P. E., Piano P., Vecchiet J., Falasca K., Sighinolfi L., Segala D., Mazzotta F., Cassola G., Viscoli C., Alessandrini A., Piscopo R., Mazzarello G., Mastroianni C., Belvisi V., Caramma I., Chiodera A., Castelli A. P., Rizzardini G., Ridolfo A. L., Piolini R., Salpietro S., Carenzi L., Moioli M. C., Tincati C., Puzzolante C., Abrescia N., Chirianni A., Borgia G., Di Martino F., Maddaloni L., Gentile I., Orlando R., Baldelli F., Francisci D., Parruti G., Ursini T., Magnani G., Ursitti M. A., Vullo V., Baldin G., Gallo L., Nicastri E., Acinapura R., Capozzi M., Libertone R., Savinelli S., Cecchetto M., Viviani F., Mura M. S., Rossetti B., Caramello P., Oro-Fino G. C., Sciandra M., Bassetti M., Londero A., Pellizzer G., and Manfrin V.

Abstract

Objective: To evaluate the Fibrosis (FIB)-4 index as a predictor of major liver-related events (LRE) and liver-related death (LRD) in human immunodeficiency virus (HIV) type-1 patients initiating combination antiretroviral therapy (cART). Design: Retrospective analysis of a prospective cohort study. Setting: Italian HIV care centers participating to the ICONA Foundation cohort. Participants: Treatment-naive patients enrolled in ICONA were selected who: initiated cART, had hepatitis C virus (HCV) serology results, were HBsAg negative, had an available FIB-4 index at cART start and during follow up. Methods: Cox regression models were used to determine the association of FIB4 with the risk of major LRE (gastrointestinal bleeding, ascites, hepatic encephalopathy, hepato-renal syndrome or hepatocellular carcinoma) or LRD. Results: Three-thousand four-hundred seventy-five patients were enrolled: 73.3% were males, 27.2% HCV seropositive. At baseline (time of cART initiation) their median age was 39 years, had a median CD4+ T cell count of 260 cells/uL, and median HIV RNA 4.9 log copies/ mL, 65.9% had a FIB-4 < 1.45, 26.4% 1.45-3.25 and 7.7% > 3.25. Over a follow up of 18,662 person-years, 41 events were observed: 25 major LRE and 16 LRD (incidence rate, IR, 2.2 per 1,000 PYFU [95% confidence interval, CI 1.6-3.0]). IR was higher in HCV seropositives as compared to negatives (5.9 vs 0.5 per 1,000 PYFU). Higher baseline FIB-4 category as compared to < 1.45 (FIB-4 1.45-3.25: HR 3.55, 95% CI 1.09-11.58; FIB-4 > 3.25: HR 4.25, 1.21-14.92) and time-updated FIB-4 (FIB-4 1.45-3.25: HR 3.40, 1.02-11.40; FIB- 4> 3.25: HR 21.24, 6.75-66.84) were independently predictive of major LRE/LRD, after adjusting for HIV- and HCV-related variables, alcohol consumption and type of cART. Conclusions: The FIB-4 index at cART initiation, and its modification over time are risk factors for major LRE or LRD, independently of infection with HCV and could be used to monitor patients on

Published
2015

131. Consensus document on controversial issues for the treatment of hospital-associated pneumonia

Author

Franzetti F, Antonelli M, Bassetti M, Blasi F, Langer M, Scaglione F, Nicastri E, Lauria FN, Carosi G, Moroni M, Ippolito G, GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) Working Group on Hospital-Associated Pneumonia, Cascio A, Franzetti F, Antonelli M, Bassetti M, Blasi F, Langer M, Scaglione F, Nicastri E, Lauria FN, Carosi G, Moroni M, Ippolito G, GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) Working Group on Hospital-Associated Pneumonia, and Cascio A

Subjects
Microbiology (medical), medicine.medical_specialty, MEDLINE, Cochrane Library, Gram-Positive Bacteria, Nosocomial pneumonia, Health care-associated pneumonia, 16Methicillin-resistant staphylococci, law.invention, Health care-associated pneumonia, Randomized controlled trial, law, Settore MED/41 - ANESTESIOLOGIA, Pneumonia, Bacterial, Humans, Medicine, NOSOCOMIAL PNEUMONIA, Methicillin-resistant staphylococci, Intensive care medicine, Gram-Positive Bacterial Infections, Randomized Controlled Trials as Topic, Cross Infection, Evidence-Based Medicine, business.industry, Bacterial pneumonia, Retrospective cohort study, General Medicine, Evidence-based medicine, medicine.disease, Anti-Bacterial Agents, Quality of evidence, Pneumonia, Treatment Outcome, Infectious Diseases, Drug Therapy, Combination, business
Abstract

Background: Hospital-associated pneumonia (HAP) remains an important cause of morbidity and mortality despite advances in antimicrobial therapy. Many aspects of the treatment of HAP caused by multi-resistant Gram-positive microorganisms have been extensively studied, but controversial issues remain. Controversial issues: The aim of this GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) working group – a panel of multidisciplinary experts – was to define recommendations for some controversial issues using an evidence-based and analytical approach. The controversial issues were: (1) Is combination antibiotic therapy or monotherapy more effective in the treatment of HAP? (2) What role do pharmacokinetic/pharmacodynamic antibiotic features have as a guide in the selection of treatment for HAP? (3) Is a de-escalation approach for the management of HAP effective? An analysis of the studies published up until April 2009 is presented and discussed in detail. Methods: A systematic literature search using PubMed, MEDLINE, and EMBASE databases and the Cochrane Library was performed. A matrix was created to extract evidence from original studies using the CONSORT method to evaluate randomized clinical trials and the Newcastle–Ottawa Quality Assessment Scale for case–control studies, longitudinal cohorts, and retrospective studies. The GRADE method for grading quality of evidence was applied. 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved

Published
2010
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132. Incidence of Malignancies in HIV‐Infected Patients and Prognostic Role of Current CD4 Cell Count: Evidence from a Large Italian Cohort Study

Author

Prosperi M.C., Cozzi Lepri A., Castagna A., Mussini C., Murri R., Giacometti A., Torti C., Costantini A., Narciso P., Ghinelli F., Antinori A., d'Arminio Monforte A., Moroni M, Carosi G, Galli M, Iardino R, Ippolito G, Lazzarin A, Panebianco R, Pastore G, Perno CF, Ammassari A, Arici C, Balotta C, Bonfanti P, Capobianchi MR, Ceccherini Silberstein F, De Luca A, Gervasoni C, Girardi E, Lo Caputo S, Puoti M, Fanti I, Formenti T, Montroni M, Riva A, Tirelli U, Martellotta F, Ladisa N, Pierri A, Suter F, Maggiolo F, Cristini G, Minardi C, Bertelli D, Quirino D, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Pagano G, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Soscia F, Tacconi L, Orani A, Rossotti R, Tommasi D, Congedo P, Chiodera A, Castelli P, Rizzardini G, Schlacht I, Ridolfo AL, Foschi A, Salpietro S, Merli S, Melzi S, Moioli MC, Cicconi P, Esposito R, Gori A, Fiorino M, Abrescia N, Chirianni A, Izzo CM, De Marco M, Viglietti R, Manzillo E, Ferrari C, Pizzaferri P, Baldelli F, Belfiori B, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Cauda R, Andreoni M, Antonucci G, Tozzi V, Vullo V, Zaccarelli M, Acinapura R, De Longis P, Trotta MP, Calbi M, Gallo L, Miccoli A, Carletti F, Mura MS, Madeddu G, Caramello P, Di Perri G, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D., BORDERI, MARCO, VERUCCHI, GABRIELLA, PIERGENTILI, BENEDETTA, Prosperi MC., Cozzi-Lepri A., Castagna A., Mussini C., Murri R., Giacometti A., Torti C., Costantini A., Narciso P., Ghinelli F., Antinori A., d'Arminio Monforte A., Moroni M, Carosi G, Galli M, Iardino R, Ippolito G, Lazzarin A, Panebianco R, Pastore G, Perno CF, Ammassari A, Arici C, Balotta C, Bonfanti P, Capobianchi MR, Ceccherini-Silberstein F, De Luca A, Gervasoni C, Girardi E, Lo Caputo S, Puoti M, Fanti I, Formenti T, Montroni M, Riva A, Tirelli U, Martellotta F, Ladisa N, Pierri A, Suter F, Maggiolo F, Borderi M, Verucchi G, Piergentili B, Cristini G, Minardi C, Bertelli D, Quirino D, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Pagano G, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Soscia F, Tacconi L, Orani A, Rossotti R, Tommasi D, Congedo P, Chiodera A, Castelli P, Rizzardini G, Schlacht I, Ridolfo AL, Foschi A, Salpietro S, Merli S, Melzi S, Moioli MC, Cicconi P, Esposito R, Gori A, Fiorino M, Abrescia N, Chirianni A, Izzo CM, De Marco M, Viglietti R, Manzillo E, Ferrari C, Pizzaferri P, Baldelli F, Belfiori B, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Cauda R, Andreoni M, Antonucci G, Tozzi V, Vullo V, Zaccarelli M, Acinapura R, De Longis P, Trotta MP, Calbi M, Gallo L, Miccoli A, Carletti F, Mura MS, Madeddu G, Caramello P, Di Perri G, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D., Prosperi, M. C. F., Cozzi lepri, A., Castagna, Antonella, Mussini, C., Murri, R., Giacometti, A., Torti, C., Costantini, A., Narciso, P., Ghinelli, F., Antinori, A., and D'arminio Monforte, A.

Subjects
Adult, Male, Microbiology (medical), tumor, medicine.medical_specialty, Prognosi, Prognosis, male, cohort studies, CD4 lymphocyte count, HIV infections, female, neoplasms, Italy, incidence, adult, humans, HIV Infections, Cohort Studies, MALIGNANCIES, HIV, AIDS, CD4, Neoplasms, Immunopathology, Internal medicine, Epidemiology, medicine, Humans, HIV Infection, Sida, biology, business.industry, Incidence, Incidence (epidemiology), Settore MED/07 - Microbiologia e Microbiologia Clinica, biology.organism_classification, Confidence interval, CD4 Lymphocyte Count, Surgery, Infectious Diseases, Cohort, Neoplasm, Female, Viral disease, Cohort Studie, business, Human, Cohort study
Abstract

The incidence of and predictors of acquired immunodeficiency syndrome-defining malignancies (ADMs) and nonADM (NADMs) were evaluated in a large Italian cohort. The incidence of ADM and NADM was 5.0 cases per 1000 personyears of follow-up (95% confidence interval, 4.3-5.8 cases per 1000 person-years of follow-up) and 2.4 cases per 1000 person-years of follow-up (95% confidence interval, 1.9-3.1 cases per 1000 person-years of follow-up), respectively. Lower current CD4 cell count was an independent predictor of developing malignancies, with the association being stronger for ADM than for NADM. © 2010 by the Infectious Diseases Society of America. All rights reserved.

Published
2010

135. Genotypic diversity of Salmonella ser. Abortusequi isolates from Argentina.

Author

Bustos, C. P., Moroni, M., Caffer, M. I., Ivanissevich, A., Herrera, M., Moreira, A. R., Guida, N., and Chacana, P.

Abstract

Summary: Background: Salmonella enterica subsp. enterica serovar Abortusequi (S. Abortusequi) is a serotype restricted to equines, which produces abortion outbreaks. Nowadays the disease is being reported in different countries including Argentina thus generating an important impact in the equine industry. Molecular characterization of the 95 kb virulence plasmid and the spvC gene of S. Abortusequi demonstrated their importance in the pathogenicity of the serotype. In the last decades, high clonality of S. Abortusequi was identified in Japan, Mongolia and Croatia. Objectives: The aim of this work was to characterize S. Abortusequi isolates obtained in Argentina between 2011 and 2016 by virulence‐gene profiling and pulsed‐field gel electrophoresis. Study design: Case report. Methods: S. Abortusequi isolates were studied by virulence‐gene profiling and pulsed‐field gel electrophoresis. Results: Four virulence profiles and nine pulsed‐field gel electrophoresis pulsotypes were identified among the 27 isolates included in the study. Different strains were found in the same outbreak and/or farm suggesting the presence of different sources of infection or mutation of isolates. Main limitations: The number of related and nonrelated strains. More isolates may be necessary for a more intensive study. Conclusions: Most strains presented the same virulence profile, being positive for all the studied genes except gipA and sopE1, which are involved in intestinal virulence. Only few isolates showed different results in the same outbreak or farm. Unlike other studies, our results demonstrate a considerable diversity of S. Abortusequi pulsed‐field gel electrophoresis pulsotypes, which suggests that different sources of infection may be involved within the same outbreak. [ABSTRACT FROM AUTHOR]

Published
2020
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136. P1789Implementation of low dose coronary CT angiography in the workflow for the assessment of new onset chest pain in clinical practice

Author

Carrabba, N, primary, Berteotti, M, additional, Taborchi, G, additional, Ciatti, F, additional, Selvi, V, additional, Consales, A, additional, Acquafresca, M, additional, Moroni, M, additional, Migliorini, A, additional, Valenti, R, additional, Miele, V, additional, Marchionni, N, additional, and Antoniucci, D, additional

Published
2018
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141. Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

Author

Servin-Vences, MR, Moroni, M, Lewin, GR, Poole, K, Servin-Vences, MR, Moroni, M, Lewin, GR, and Poole, K

Abstract

The joints of mammals are lined with cartilage, comprised of individual chondrocytes embedded in a specialized extracellular matrix. Chondrocytes experience a complex mechanical environment and respond to changing mechanical loads in order to maintain cartilage homeostasis. It has been proposed that mechanically gated ion channels are of functional importance in chondrocyte mechanotransduction; however, direct evidence of mechanical current activation in these cells has been lacking. We have used high-speed pressure clamp and elastomeric pillar arrays to apply distinct mechanical stimuli to primary murine chondrocytes, stretch of the membrane and deflection of cell-substrate contacts points, respectively. Both TRPV4 and PIEZO1 channels contribute to currents activated by stimuli applied at cell-substrate contacts but only PIEZO1 mediates stretch-activated currents. These data demonstrate that there are separate, but overlapping, mechanoelectrical transduction pathways in chondrocytes.

Published
2017

144. Non-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation

Author

Moroni, M, Vijayan, R, Carbone, A, Zwart, R, Biggin, PC, and Bermudez, I

Subjects
integumentary system, urogenital system, embryonic structures, sense organs
Abstract

The alpha4beta2 subtype is the most abundant nicotinic acetylcholine receptor (nAChR) in the brain and possesses the high-affinity binding site for nicotine. The alpha4 and beta2 nAChR subunits assemble into two alternate stoichiometries, (alpha4)(2)(beta2)(3) and (alpha4)(3)(beta2)(2), which differ in their functional properties and sensitivity to chronic exposure to nicotine. Here, we investigated the sensitivity of both receptor stoichiometries to modulation by Zn2+. We show that Zn2+ exerts an inhibitory modulatory effect on (alpha4)(2)(beta2)(3) receptors, whereas it potentiates or inhibits, depending on its concentration, the function of (alpha4)(3)(beta2)(2) receptors. Furthermore, Zn2+ inhibition on (alpha4)(2)(beta2)(3) nAChRs is voltage-dependent, whereas it is not on (alpha4)(3)(beta2)(2) receptors. We used molecular modeling in conjunction with alanine substitution and functional studies to identify two distinct sets of residues that determine these effects and may coordinate Zn(2+). Zn(2+) inhibition is mediated by a site located on the beta2(+)/alpha4(-) subunit interfaces on both receptor stoichiometries. alpha4(H195) and beta2(D218) are key determinants of this site. Zn2+ potentiation on (alpha4)(3)(beta2)(2) nAChRs is exerted by a site that resides on the alpha4(+)/alpha4(-) of this receptor stoichiometry. alpha4(H195) on the (-) side of the ACh-binding alpha4 subunit and alpha4(E224) on the (+) side of the non-ACh-binding alpha4 subunit critically contribute to this site. We also identified residues within the beta2 subunit that confer voltage dependency to Zn2+ inhibition on (alpha4)(2)(beta2)(3), but not on (alpha4)(3)(beta2)(2) nAChRs.

Published
2016

145. Persistence of slow fluctuations in the overdoped regime of Ba ( Fe 1 − x Rh x ) 2 As 2 superconductors

Author

Bossoni, L., Moroni, M., Julien, Marc-Henri, Mayaffre, H., Canfield, P., Reyes, A., Halperin, P., Carretta, P., Laboratoire national des champs magnétiques intenses - Grenoble (LNCMI-G ), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])

Subjects
[PHYS]Physics [physics], [PHYS.COND.CM-S]Physics [physics]/Condensed Matter [cond-mat]/Superconductivity [cond-mat.supr-con], [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

146. Pregnancy Outcomes Among ART-Naive and ART-Experienced HIV-Positive Women: Data From the ICONA Foundation Study Group, Years 1997-2013

Author

Moroni, M, Andreoni, M, Angarano, G, Antinori, A, d'Arminio Monforte, A, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, CF, von Schloesser, F, Viale, P, Castagna, A, Ceccherini Silberstein, F, Cozzi Lepri, A, Girardi, E, Lo Caputo, S, Mussini, C, Puoti, M, Ammassari, A, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, MR, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gianotti, N, Guaraldi, G, Lapadula, G, Lichtner, M, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Quiros Roldan, E, Rusconi, S, Cicconi, P, Fanti, I, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantin, A, Mazzoccato, S, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, PE, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, AP, Rizzardini, G, Ridolfo, AL, Piolini, R, Salpietro, S, Carenzi, L, Moioli, MC, Tincati, C, Puzzolante, C, Gori, A, Abrescia, N, Chirianni, A, Guida, MG, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, MA, Vullo, V, d'Avino, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Sasset, L, Mura, MS, Rossetti, B, Caramello, P, Orofino, GC, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V., GORI, ANDREA, d'Arminio Monforte, Antonella, Galli, Laura, Lo Caputo, Sergio, Lichtner, Miriam, Pinnetti, Carmela, Bobbio, Nicoletta, Francisci, Daniela, Costantini, Andrea, Cingolani, Antonella, Castelli, Francesco, Girardi, Enrico, Castagna, Antonella, Moroni, M, Andreoni, M, Angarano, G, Antinori, A, d'Arminio Monforte, A, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, C, von Schloesser, F, Viale, P, Castagna, A, Ceccherini Silberstein, F, Cozzi Lepri, A, Girardi, E, Lo Caputo, S, Mussini, C, Puoti, M, Ammassari, A, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, M, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Lapadula, G, Lichtner, M, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Quiros Roldan, E, Rusconi, S, Cicconi, P, Fanti, I, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantin, A, Mazzoccato, S, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Cassola, G, Viscoli, C, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Castelli, A, Rizzardini, G, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, M, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Vullo, V, D'Avino, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Sasset, L, Mura, M, Rossetti, B, Caramello, P, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, and Manfrin, V

Subjects
Pediatrics, Multivariate analysis, Infectious Disease Transmission, Protease Inhibitor, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Retrospective Studie, Pregnancy, Antiretroviral Therapy, Highly Active, Vertical, HIV Infection, Pharmacology (medical), Viral, Pregnancy Complications, Infectious, Multivariate Analysi, ART experienced, ART naives, Detectable viral load, Preterm delivery, Adult, Anti-HIV Agents, CD4 Lymphocyte Count, Female, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Italy, Multivariate Analysis, Protease Inhibitors, RNA, Viral, Retrospective Studies, Viral Load, Pregnancy Outcome, Infectious Diseases, Infectious, Cohort, Viral load, Human, medicine.medical_specialty, Antiretroviral Therapy, Settore MED/17 - MALATTIE INFETTIVE, NO, medicine, Highly Active, Pregnancy outcomes, business.industry, Anti-HIV Agent, Infant, Retrospective cohort study, medicine.disease, Newborn, Antiretroviral therapy, Pregnancy Complications, Immunology, Pregnancy Complications, Infectiou, RNA, business
Abstract

Background: We analyzed antiretroviral therapy (ART) regimens and pregnancy outcomes in naive and ART-experienced HIV-positive women from Italian Cohort Naive Antiretrovirals cohort and investigated frequency and predictors of detectable viral load (VL) at delivery. Methods: All pregnancies resulting in live births were included. Based on ART at the beginning of pregnancy, pregnancies were allocated either to the ART-naive or ART-experienced group. Analyses were stratified according to calendar periods. Multivariate logistic regression was used to describe predictors of detectable VL at delivery. Results: One hundred fifty-eight of 2862 women experienced 169 pregnancies (88 in naives and 81 in 70 ART-experienced women). ART regimens varied according to calendar periods; mono-dual combination regimens progressively decreased over time (P value for trend 50 copies per milliliter at pregnancy ascertainment (adjusted odds ratio: 7.1, 95% confidence interval: 1.9 to 33.3, P = 0.006). Nevertheless, no cases of vertical transmission were diagnosed. Preterm birth rate of 17.3% (11.9% vs 22.6% naive and ART experienced, P = 0.1) was reported; this was not associated with ART duration or protease inhibitor-including regimens; 27.2% of infants had

Published
2014

148. Immune activation and microbial translocation in liver disease progression in HIV/hepatitis co-infected patients: results from the Icona Foundation study

Author

Marchetti, Giulia, Cozzi Lepri, Alessandro, Tincati, Camilla, Calcagno, Andrea, Ceccherini Silberstein, Francesca, De Luca, Andrea, Antinori, Andrea, Castagna, Antonella, Puoti, Massimo, Monforte, Antonella d'Arminio, for the Icona Foundation Study Group […, Moroni M, Angarano G, Antinori A, Carosi G, Cauda R, Monforte A, Di Perri G, Galli M, Iardino R, Ippolito G, Lazzarin A, Perno CF, Viale PL, Von Schlosser F, Monforte Ad, Ammassari A, Andreoni M, Balotta C, Bonfanti P, Bonora S, Borderi M, Capobianchi MR, Castagna A, Ceccherini Silberstein F, Cozzi Lepri A, De Luca A, Gargiulo M, Gervasoni C, Girardi E, Lichtner M, Lo Caputo S, Madeddu G, Maggiolo F, Marcotullio S, Monno L, Murri R, Mussini C, Puoti M, Torti C, Fanti I, Formenti T, Montroni M, Giacometti A, Costantini A, Riva A, Tirelli U, Martellotta F, Ladisa N, Suter F, Piergentili B, Cristini G, Minardi C, Bertelli D, Quirino T, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Molteni C, Chiodera A, Castelli P, Rizzardini G, Ridolfo AL, Foschi A, Salpietro S, Merli S, Carenzi L, Moioli MC, Cicconi P, Esposito R, Gori A, Pastore V, Abrescia N, Chirianni A, De Marco M, Ferrari C, Borghi R, Baldelli F, Belfiori B, Parruti G, Sozio F, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Antonucci G, Narciso P, Tozzi V, Vullo V, Zaccarelli M, Gallo L, Acinapura R, De Longis P, Ceccarelli L, Libertone R, Trotta MP, Miccoli A, Cattelan AM, Mura MS, Caramello P, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D, VERUCCHI, GABRIELLA, Marchetti, G, Cozzi Lepri, A, Tincati, C, Calcagno, A, Ceccherini Silberstein, F, DE LUCA, A, Antinori, A, Castagna, A, Puoti, M, Monforte, A, Marchetti, Giulia, Cozzi Lepri, Alessandro, Tincati, Camilla, Calcagno, Andrea, Ceccherini Silberstein, Francesca, De Luca, Andrea, Antinori, Andrea, Castagna, Antonella, Puoti, Massimo, Monforte Antonella, D'Arminio, Cozzi-Lepri, Alessandro, Ceccherini-Silberstein, Francesca, Monforte, Antonella d'Arminio, and for the Icona Foundation Study Group […, Moroni M, Angarano G, Antinori A, Carosi G, Cauda R, Monforte A, Di Perri G, Galli M, Iardino R, Ippolito G, Lazzarin A, Perno CF, Viale PL, Von Schlosser F, Monforte Ad, Ammassari A, Andreoni M, Balotta C, Bonfanti P, Bonora S, Borderi M, Capobianchi MR, Castagna A, Ceccherini-Silberstein F, Cozzi-Lepri A, De Luca A, Gargiulo M, Gervasoni C, Girardi E, Lichtner M, Lo Caputo S, Madeddu G, Maggiolo F, Marcotullio S, Monno L, Murri R, Mussini C, Puoti M, Torti C, Fanti I, Formenti T, Montroni M, Giacometti A, Costantini A, Riva A, Tirelli U, Martellotta F, Ladisa N, Suter F, Verucchi G, Piergentili B, Cristini G, Minardi C, Bertelli D, Quirino T, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Molteni C, Chiodera A, Castelli P, Rizzardini G, Ridolfo AL, Foschi A, Salpietro S, Merli S, Carenzi L, Moioli MC, Cicconi P, Esposito R, Gori A, Pastore V, Abrescia N, Chirianni A, De Marco M, Ferrari C, Borghi R, Baldelli F, Belfiori B, Parruti G, Sozio F, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Antonucci G, Narciso P, Tozzi V, Vullo V, Zaccarelli M, Gallo L, Acinapura R, De Longis P, Ceccarelli L, Libertone R, Trotta MP, Miccoli A, Cattelan AM, Mura MS, Caramello P, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D, …], DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE, Facolta' di MEDICINA e CHIRURGIA, and AREA MIN. 06 - Scienze mediche

Subjects
microbial, Male, Fibrosi, Lipopolysaccharide Receptors, HIV Infections, Kaplan-Meier Estimate, Liver disease, Medical microbiology, Risk Factors, HIV Infection, Fib-4, Coinfection, Liver Disease, Medicine (all), Liver Diseases, virus diseases, Hepatitis A, Hepatitis C, Hepatitis B, Middle Aged, sCD14, Settore MED/07 - Microbiologia e Microbiologia Clinica, Infectious Diseases, Treatment Outcome, HIV/hepatitis co-infection, traslocation, HCV, HIV, liver, Disease Progression, Biological Markers, Female, medicine.symptom, Adult, Antigens, CD14, CD4 Lymphocyte Count, Enzyme-Linked Immunosorbent Assay, Fibrosis, Humans, Inflammation, CD14, Microbial translocation, Research Article, Human, medicine.medical_specialty, Infectious Disease, Settore MED/17 - MALATTIE INFETTIVE, Biomarkers, medicine, Antigens, Hepatitis, business.industry, Risk Factor, Biomarker, medicine.disease, Virology, digestive system diseases, Immunology, business
Abstract

none 157 no Abstract BACKGROUND: We evaluated whether immune activation (IA) and microbial translocation (MT) might play a role in accelerating liver disease progression in HIV-HBV/HCV co-infected patients. METHODS: ART-naïve HIV/viral hepatitis co-infected patients from Icona with a CD4 cell count >200/μl and with a known date of prior HIV neg/pos tests and ≥1 plasma sample stored were included in the study. Plasma MT (LPS, sCD14) and IA (IL-6,TNFα) were measured using ELISA while activated CD8 + CD38 + HLA-DR + were measured by flow cytometry, with one measurement being performed for all patients and two measurements for a smaller group of subjects. The association between these biomarkers and the time to i) a single ALT >200 IU/l and ii) a Fib-4 >1.45 was also investigated. A standard survival analysis with robust standard errors was used for all evaluations. Follow-up was censored at patients' last clinical follow-up. RESULTS: We studied 127 HIV-infected hepatitis viruses co-infected patients (118 HCV, 9 HBV). Overall median (IQR) CD4, VL, age were 596/μl (208-1303), 3.8 log10cp/mL (3-4.3), 34 years (22-56). While heightened TNF-α was associated with a 13-fold increased risk of Fib-4 > 1.45 (RH 13.05, 95% CI 2.43-70; p = 0.003), markers of MT did not show an association with liver illness. Interestingly, higher sCD14 was associated with a decreased risk of Fib-4 > 1.45, independently of other biomarkers considered (RH 0.20, 95% CI 0.04-0,9; p = 0.04). CONCLUSIONS: In HIV/hepatitis virus co-infected ART-naive patients, higher TNF-α plasma levels were associated with a 13-fold increase in the risk of progression to a Fib-4 >1.45, suggesting that the pro-inflammatory status in HIV infection might hasten the course of HCV. In view of the fact that sCD14 may hinder the interaction between LPS and the phagocyte membrane CD14, we herewith propose a model which aims to demonstrate that high sCD14 levels might contribute to shelter liver function through the down-regulation of the inflammatory cascade. Marchetti, Giulia; Cozzi-Lepri, Alessandro; Tincati, Camilla; Calcagno, Andrea; Ceccherini-Silberstein, Francesca; De Luca, Andrea; Antinori, Andrea; Castagna, Antonella; Puoti, Massimo; Monforte, Antonella d'Arminio; and for the Icona Foundation Study Group […; Moroni M; Angarano G; Antinori A; Carosi G; Cauda R; Monforte A; Di Perri G; Galli M; Iardino R; Ippolito G; Lazzarin A; Perno CF; Viale PL; Von Schlosser F; Monforte Ad; Ammassari A; Andreoni M; Antinori A; Balotta C; Bonfanti P; Bonora S; Borderi M; Capobianchi MR; Castagna A; Ceccherini-Silberstein F; Cozzi-Lepri A; Monforte A; De Luca A; Gargiulo M; Gervasoni C; Girardi E; Lichtner M; Lo Caputo S; Madeddu G; Maggiolo F; Marcotullio S; Monno L; Murri R; Mussini C; Puoti M; Torti C; Cozzi-Lepri A; Fanti I; Formenti T; Montroni M; Giacometti A; Costantini A; Riva A; Tirelli U; Martellotta F; Angarano G; Monno L; Ladisa N; Suter F; Maggiolo F; Viale PL; Verucchi G; Piergentili B; Carosi G; Cristini G; Torti C; Minardi C; Bertelli D; Quirino T; Abeli C; Manconi PE; Piano P; Vecchiet J; Falasca K; Carnevale G; Lorenzotti S; Sighinolfi L; Leoncini F; Mazzotta F; Pozzi M; Lo Caputo S; Cassola G; Viscoli G; Alessandrini A; Piscopo R; Mazzarello G; Mastroianni C; Belvisi V; Bonfanti P; Molteni C; Chiodera A; Castelli P; Galli M; Lazzarin A; Rizzardini G; Puoti M; Monforte A; Ridolfo AL; Foschi A; Castagna A; Salpietro S; Merli S; Carenzi L; Moioli MC; Cicconi P; Formenti T; Esposito R; Mussini C; Gori A; Pastore V; Abrescia N; Chirianni A; De Marco M; Ferrari C; Borghi R; Baldelli F; Belfiori B; Parruti G; Sozio F; Magnani G; Ursitti MA; Arlotti M; Ortolani P; Cauda R; Andreoni M; Antinori A; Antonucci G; Narciso P; Tozzi V; Vullo V; De Luca A; Zaccarelli M; Gallo L; Acinapura R; De Longis P; Ceccarelli L; Libertone R; Trotta MP; Miccoli A; Cattelan AM; Mura MS; Madeddu G; Caramello P; Di Perri G; Orofino GC; Sciandra M; Raise E; Ebo F; Pellizzer G; Buonfrate D; …] Marchetti, Giulia; Cozzi-Lepri, Alessandro; Tincati, Camilla; Calcagno, Andrea; Ceccherini-Silberstein, Francesca; De Luca, Andrea; Antinori, Andrea; Castagna, Antonella; Puoti, Massimo; Monforte, Antonella d'Arminio; and for the Icona Foundation Study Group […; Moroni M; Angarano G; Antinori A; Carosi G; Cauda R; Monforte A; Di Perri G; Galli M; Iardino R; Ippolito G; Lazzarin A; Perno CF; Viale PL; Von Schlosser F; Monforte Ad; Ammassari A; Andreoni M; Antinori A; Balotta C; Bonfanti P; Bonora S; Borderi M; Capobianchi MR; Castagna A; Ceccherini-Silberstein F; Cozzi-Lepri A; Monforte A; De Luca A; Gargiulo M; Gervasoni C; Girardi E; Lichtner M; Lo Caputo S; Madeddu G; Maggiolo F; Marcotullio S; Monno L; Murri R; Mussini C; Puoti M; Torti C; Cozzi-Lepri A; Fanti I; Formenti T; Montroni M; Giacometti A; Costantini A; Riva A; Tirelli U; Martellotta F; Angarano G; Monno L; Ladisa N; Suter F; Maggiolo F; Viale PL; Verucchi G; Piergentili B; Carosi G; Cristini G; Torti C; Minardi C; Bertelli D; Quirino T; Abeli C; Manconi PE; Piano P; Vecchiet J; Falasca K; Carnevale G; Lorenzotti S; Sighinolfi L; Leoncini F; Mazzotta F; Pozzi M; Lo Caputo S; Cassola G; Viscoli G; Alessandrini A; Piscopo R; Mazzarello G; Mastroianni C; Belvisi V; Bonfanti P; Molteni C; Chiodera A; Castelli P; Galli M; Lazzarin A; Rizzardini G; Puoti M; Monforte A; Ridolfo AL; Foschi A; Castagna A; Salpietro S; Merli S; Carenzi L; Moioli MC; Cicconi P; Formenti T; Esposito R; Mussini C; Gori A; Pastore V; Abrescia N; Chirianni A; De Marco M; Ferrari C; Borghi R; Baldelli F; Belfiori B; Parruti G; Sozio F; Magnani G; Ursitti MA; Arlotti M; Ortolani P; Cauda R; Andreoni M; Antinori A; Antonucci G; Narciso P; Tozzi V; Vullo V; De Luca A; Zaccarelli M; Gallo L; Acinapura R; De Longis P; Ceccarelli L; Libertone R; Trotta MP; Miccoli A; Cattelan AM; Mura MS; Madeddu G; Caramello P; Di Perri G; Orofino GC; Sciandra M; Raise E; Ebo F; Pellizzer G; Buonfrate D; …]

Published
2014

149. Tumor venéreo transmisible diseminado sobre piel, párpados y pene en un perro: Reporte de caso

Author

Ojeda, J, Alfaro, A, Moroni, M, Camacho, V, Martínez, J, and Noro, M

Subjects
canine transmissible tumor, skin, dogs, canino, metástasis, vincristine, tumor venéreo transmisible, piel
Abstract

Canine venereal transmissible tumor (CTVT) is a round cell benign neoplasia that affects the external genital mucous which is transmitted during coitus with infected dogs. The normal canine behaviour such as smelling and sucking allow the tumoral cells to implant into extragenital zones with subsequent metastases formation. This report described a dog with multiple skin nodules localised in the thoracolumbar area and eyes. The nodules were ulcered and alopecic with purulent fluid around them. A granulomatous mass with focal necrosis area was also detected with bilateral keratitis. Citological analysis of skin nodules, eyelid tissue and granulomatous tissue on the base of the penis suggested a CTVT, and the histopathological analysis confirmed the diagnosis of CTVT. Also LINE-1 rearrangement in c-myc was detected as a genetic alteration of the CTVT. A chemotherapy protocol was started with vincristine sulfate. Haemograms were used previous to each chemotherapy sessions to prevent myelosuppression. A moderate non regenerative anemia was observed after the third session but it was resolved by discontinuing chemotherapy for two weeks. The chemotherapy was effective to eliminate the CTVT after six sessions. &nbsp, El tumor venéreo transmisible canino (TVT) es una neoplasia benigna de células redondas que afecta frecuentemente la mucosa genital externa de perros. El olfateo y el lamido permiten la implantación de las células tumorales en zonas extragenitales con formación de metástasis. Se relata un caso de TVT diseminado en piel, párpados y pene en un perro macho mestizo. Las lesiones localizadas en la parte dorsal y lateral de la zona torácica y abdominal presentaban varios nódulos alopécicos ulcerados y bien vascularizados, con aspecto friable y con secreción purulenta. El párpado superior izquierdo y derecho presentaban una masa granulosa con áreas de necrosis y queratitis bilateral. En la base del pene se presentaba una masa granulosa firme y bien delimitada. El análisis citológico de los nódulos cutáneos, de los párpados y la masa del pene reveló hallazgos compatibles con TVT, el que fue confirmado con análisis histopatológico. Además se determinó la presencia de LINE-1 en el oncogen c-myc como una alteración genética conocida para CTVT. Se estableció un protocolo quimioterápico sobre la base de sulfato de vincristina. Previo a cada sesión de quimioterapia se tomaron hemogramas para prevenir mielosupresión. Posterior a la tercera sesión se observó una anemia no regenerativa moderada que fue resuelta suspendiendo durante 2 semanas la terapia. La terapia con sulfato de vincristina fue efectiva para producir la regresión de todos los tumores en 6 sesiones, sin mostrar recurrencia. &nbsp

Published
2016

150. Cumulative and current exposure to potentially nephrotoxic antiretrovirals and development of chronic kidney disease in HIV-positive individuals with a normal baseline estimated glomerular filtration rate: a prospective international cohort study

Author

Steering, D, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Ryom, L, Hatleberg, Ci, Sabin, Ca, Kamara, D, Smith, C, Phillips, A, Mocroft, A, Bojesen, A, Grevsen, A, Matthews, C, Raben, D, Lundgren, Jd, Brandt, Rs, Rickenbach, M, Fanti, I, Hillebreght, M, Zaheri, S, Gras, L, Pernot, E, Mourabi, J, Sundström, A, Delforge, M, Fontas, E, Torres, F, Mcmanus, H, Wright, S, Kristensen, D, Sjøl, A, Meidahl, P, Helweg-Larsen, J, Schmidt Iversen, J, Kirk, O, Reiss, P, Smit, C, Ross, M, Fux, Ca, Morlat, P, Moranne, O, Kamara, Da, Weber, R, Pradier, C, Friis-Møller, N, Kowalska, J, Sabin, C, Law, M, d'Arminio Monforte, A, Dabis, F, Bruyand, M, Bonnet, F, Bower, M, Fätkenheuer, G, Donald, A, Grulich, A, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, van der Meer JT, Wit, Fw, Godfried, Mh, van der Poll, T, Nellen, Fj, Geerlings, Se, van Vugt, M, Pajkrt, D, Bos, Jc, Wiersinga, Wj, van der Valk, M, Goorhuis, A, Hovius, Jw, van Eden, J, Henderiks, A, van Hes AM, Mutschelknauss, M, Nobel, He, Pijnappel, Fj, Westerman, Am, Jurriaans, S, Back, Nk, Zaaijer, Hl, Berkhout, B, Cornelissen, Mt, Schinkel, Cj, Thomas, Xv, De Ruyter Ziekenhuis, A, van den Berge, M, Stegeman, A, Baas, S, de Looff, L, Versteeg, D, Pronk, Mj, Ammerlaan, Hs, Korsten-Vorstermans, Em, de Munnik ES, Jansz, Ar, Tjhie, J, Wegdam, Mc, Deiman, B, Scharnhorst, V, Kinderziekenhuis, E, van der Plas, A, Weijsenfeld, Am, van der Ende ME, de Vries-Sluijs TE, van Gorp EC, Schurink, Ca, Nouwen, Jl, Verbon, A, Rijnders, Bj, Bax, Hi, Hassing, Rj, van der Feltz, M, Bassant, N, van Beek JE, Vriesde, M, van Zonneveld LM, de Oude-Lubbers, A, van den Berg-Cameron HJ, Bruinsma-Broekman, Fb, de Groot, J, de Man de, Z, Broekhoven-Kruijne, Mj, Schutten, M, Osterhaus, Ad, Boucher, Ca, Driessen, Gj, van Rossum AM, van der Knaap LC, Visser, E, Branger, J, Duijf-van de Ven CJ, Haag, D, Schippers, Ef, van Nieuwkoop, C, Brimicombe, Rw, van IJperen, M, van der Hut, G, Franck, Pf, van Eeden, A, Brokking, W, Groot, M, Damen, M, Kwa, 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Edwards, S, Hoy, J, Watson, K, Roth, N, Nicholson, J, Bloch, M, Franic, T, Baker, D, Vale, R, Carr, A, Cooper, D, Chuah, J, Ngieng, M, Nolan, D, Skett, J, Calvo, G, Mateu, S, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, De Wit, S, Clumeck, N, Necsoi, C, Gennotte, Af, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Martin, C, Payen, Mc, Semaille, P, Van, Y, Neaton, J, Bartsch, G, El-Sadr, Wm, Krum, E, Thompson, G, Wentworth, D, Luskin-Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Lr, Sampson, J, Baxter, J, Losso, M, Kundro, M, Vetter, N, Zangerle, R, Karpov, I, Vassilenko, A, Mitsura, Vm, Paduto, D, Florence, E, Vandekerckhove, L, Hadziosmanovic, V, Kostov, K, Begovac, J, Machala, L, Jilich, D, Sedlacek, D, Kronborg, G, Benfield, T, Gerstoft, J, Katzenstein, T, Hansen, Ab, Pedersen, C, Møller, Nf, Ostergaard, L, Dragsted, Ub, Nielsen, Ln, Zilmer, K, Smidt, J, Ristola, M, Aho, I, Katlama, C, Viard, Jp, Girard, Pm, Cotte, L, Duvivier, C, Rockstroh, J, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, Hj, Stefan, C, Bogner, J, Chkhartishvili, N, Kosmidis, J, Gargalianos, P, Xylomenos, G, Lourida, P, Sambatakou, H, Banhegyi, D, Gottfredsson, M, Mulcahy, F, Yust, I, Turner, D, Burke, M, Shahar, E, Hassoun, G, Elinav, H, Haouzi, M, Sthoeger, Zm, D'Arminio Monforte, A, Esposito, R, Mazeu, I, Mussini, C, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Zaccarelli, M, Antinori, A, Acinapura, R, D'Offizi, G, Lazzarin, A, Castagna, A, Gianotti, N, Galli, M, Ridolfo, A, Rozentale, B, Uzdaviniene, V, Matulionyte, R, Staub, T, Hemmer, R, Ormaasen, V, Maeland, A, Bruun, J, Knysz, B, Gasiorowski, J, Inglot, M, Horban, A, Bakowska, E, Grzeszczuk, A, Flisiak, R, Parczewski, M, Pynka, M, Maciejewska, K, Beniowski, M, Mularska, E, Smiatacz, T, Gensing, M, Jablonowska, E, Malolepsza, E, Wojcik, K, Mozer-Lisewska, I, Doroana, M, 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G, Perno, Cf, von Schloesser, F, Viale, P, Ceccherini-Silberstein, F, Girardi, E, Lo Caputo, S, Puoti, M, Andreoni, M, Ammassari, A, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, R, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Quiros Roldan, E, Rusconi, S, Cicconi, P, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantini, A, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Castelli, A, Rizzardini, G, Ridolfo, Al, Piolini, R, Salpietro, S, Carenzi, L, Moioli, Mc, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, Mg, Onofrio, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, Ma, D'Avino, A, Gallo, L, Nicastri, E, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Mura, Ms, Caramello, P, Orofino, Gc, Sciandra, M, Pellizzer, G, Manfrin, V, Castelli, Ap, Dollet, K, Caissotti, C, Dellamonica, P, Bernard, E, Cua, E, De Salvador-Guillouet, F, Durant, J, Ferrando, S, Dunais, B, Mondain-Miton, V, Naqvi, A, Perbost, I, Prouvost-Keller, B, Pillet, S, Pugliese, P, Risso, K, Roger, Pm, Aubert, V, Bernasconi, E, Böni, J, Bucher, Hc, Burton-Jeangros, C, Dollenmaier, G, Egger, M, Fehr, J, Fellay, J, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, Hh, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Martinetti, G, Martinez de Tejada, B, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schüpbach, J, Speck, R, Tarr, P, Telenti, A, Trkola, A, Vernazza, P, Yerly, S., University College of London [London] (UCL), Rigshospitalet [Copenhagen], Copenhagen University Hospital, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Chemical Biology, Internal Medicine, Medical Microbiology & Infectious Diseases, Pediatrics, Virology, Mocroft, A:, Lundgren, Jd, Ross, M, Fux, Ca, Reiss, P, Moranne, O, Morlat., P, Monforte, Ad, Kirk, O, Ryom, L, for the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D), Study, Lazzarin, A, Castagna, A, Other departments, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Global Health, Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology, General Internal Medicine, Center of Experimental and Molecular Medicine, Graduate School, Medical Microbiology and Infection Prevention, Gastroenterology and Hepatology, APH - Health Behaviors & Chronic Diseases, Med Microbiol, Infect Dis & Infect Prev, MUMC+: DA MMI Staf (9), MUMC+: MA Alg Interne Geneeskunde (9), MUMC+: DA MMI Infectieserologie (9), MUMC+: DA MMI AIOS (9), RS: FHML non-thematic output, Mocroft, A, Lundgren, J, Fux, C, Morlat, P, Monforte, A, and Gori, A

Subjects
0301 basic medicine, Male, PROTEASE INHIBITOR, Epidemiology, Infectious Diseases, Immunology, Virology, Research Support, U.S. Gov't, P.H.S, HIV Infections, SDG 3 – Goede gezondheid en welzijn, Rate ratio, THERAPY, chemistry.chemical_compound, 0302 clinical medicine, HIV, antiretroviral, kidney disease, immune system diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine and Health Sciences, HIV Infection, 030212 general & internal medicine, Prospective Studies, Renal Insufficiency, Chronic, Prospective cohort study, Research Support, Non-U.S. Gov't, Antiretrovirals, virus diseases, Lopinavir, ASSOCIATION, Middle Aged, 3. Good health, Europe, Antiretrovirals, HIV, chronic kidney disease, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, NAIVE PATIENTS, CREATININE, Human, Cohort study, medicine.drug, Glomerular Filtration Rate, United State, Adult, medicine.medical_specialty, TENOFOVIR DISOPROXIL FUMARATE, RENAL-FUNCTION, Adolescent, Anti-HIV Agents, Atazanavir Sulfate, Renal function, Infectious Disease, Australia, Humans, Renal Insufficiency, Chronic, Tenofovir, United States, Young Adult, NO, 03 medical and health sciences, EFAVIRENZ, SDG 3 - Good Health and Well-being, Internal medicine, Journal Article, medicine, Creatinine, business.industry, Anti-HIV Agent, medicine.disease, 030112 virology, Atazanavir, INFECTED INDIVIDUALS, Prospective Studie, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], chemistry, RISK-FACTORS, business, chronic kidney disease, Kidney disease
Abstract

BACKGROUND: Whether or not the association between some antiretrovirals used in HIV infection and chronic kidney disease is cumulative is a controversial topic, especially in patients with initially normal renal function. In this study, we aimed to investigate the association between duration of exposure to antiretrovirals and the development of chronic kidney disease in people with initially normal renal function, as measured by estimated glomerular filtration rate (eGFR).METHODS: In this prospective international cohort study, HIV-positive adult participants (aged ≥16 years) from the D:A:D study (based in Europe, the USA, and Australia) with first eGFR greater than 90 mL/min per 1·73 m(2) were followed from baseline (first eGFR measurement after Jan 1, 2004) until the occurrence of one of the following: chronic kidney disease; last eGFR measurement; Feb 1, 2014; or final visit plus 6 months (whichever occurred first). Chronic kidney disease was defined as confirmed (>3 months apart) eGFR lower than 60 mL/min per 1·73 m(2). The primary outcome was the occurrence of chronic kidney disease. Poisson regression was used to estimate the incidence rate of chronic kidney disease associated with cumulative exposure to tenofovir disoproxil fumarate, ritonavir-boosted atazanavir, ritonavir-boosted lopinavir, other ritonavir-boosted protease inhibitors, or abacavir.FINDINGS: Between Jan 1, 2004, and July 26, 2013, 23,905 eligible individuals from the D:A:D study were included. Participants had a median baseline eGFR of 110 mL/min per 1·73 m(2) (IQR 100-125), a median age of 39 years (33-45), and median CD4 cell count of 441 cells per mm(3) (294-628). During a median follow-up of 7·2 years (IQR 5·1-8·9), 285 (1%) of 23,905 people developed chronic kidney disease (incidence 1·76 per 1000 person-years of follow-up [95% CI 1·56-1·97]). After adjustment, we recorded a significant increase in chronic kidney disease associated with each additional year of exposure to tenofovir disoproxil fumarate (adjusted incidence rate ratio 1·14 [95% CI 1·10-1·19], pINTERPRETATION: In people with normal renal function, the annual incidence of chronic kidney disease increased for up to 6 years of exposure to tenofovir disoproxil fumarate, ritonavir-boosted atazanavir, or ritonavir-boosted lopinavir therapy. Although the absolute number of new cases of chronic kidney disease was modest, treatment with these antiretrovirals might result in an increasing and cumulative risk of chronic kidney disease. Patients on potentially nephrotoxic antiretrovirals or at high risk of chronic kidney disease should be closely monitored.FUNDING: The Highly Active Antiretroviral Therapy Oversight Committee.

Published
2016

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