101. Safety of a botanical extract derived from Panax notoginseng and Astragalus membranaceus (AstraGin™) as a novel food pursuant to Regulation (EU) 2015/2283
- Author
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Turck, Dominique, Castenmiller, Jacqueline, De Henauw, Stefaan, Hirsch-Ernst, Karen Ildico, Kearney, John, Maciuk, Alexandre, Mangelsdorf, Inge, McArdle, Harry J., Naska, Androniki, Pelaez, Carmen, Pentieva, Kristina, Siani, Alfonso, Thies, Frank, Tsabouri, Sophia, Vinceti, Marco, Cubadda, Francesco, Engel, Karl Heinz, Frenzel, Thomas, Heinonen, Marina, Marchelli, Rosangela, Neuhauser-Berthold, Monika, Poulsen, Morten, Schlatter, Josef Rudolf, van Loveren, Henk, Ackerl, Reinhard, Knutsen, Helle Katrine, Nutr Novel Foods Food, EFSA Panel, Department of Food and Nutrition, Helsinki One Health (HOH), and Food Quality & Safety
- Subjects
Agriculture and Food Sciences ,safety ,Veterinary (miscellaneous) ,Panax notoginseng ,Novel food ,TP1-1185 ,Plant Science ,01 natural sciences ,Microbiology ,03 medical and health sciences ,Astragalus membranaceus ,Astragalus propinquus ,extract ,novel food ,TX341-641 ,SYSTEMIC-LUPUS-ERYTHEMATOSUS ,PHARMACOLOGY ,030304 developmental biology ,2. Zero hunger ,0303 health sciences ,biology ,Traditional medicine ,Nutrition. Foods and food supply ,Chemical technology ,Biology and Life Sciences ,biology.organism_classification ,0104 chemical sciences ,3. Good health ,Chemistry ,010404 medicinal & biomolecular chemistry ,Astragalus ,416 Food Science ,T-CELLS ,Animal Science and Zoology ,Parasitology ,L-CANAVANINE ,PHYTOCHEMISTRY ,Food Science - Abstract
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on a botanical extract derived from both Panax notoginseng and Astragalus membranaceus (AstraGin (TM)) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is a combination of an ethanol extract of the roots of A. membranaceus and a hot water extract of the roots of P notoginseng. The NF contains 1.5-5% total saponins, 0.1-0.5% ginsenoside Rb1 and 0.01-0.1% astragaloside I. Both plants that are used to produce the NF have a long history of use, especially in traditional Chinese medicine. Information on the production process and the composition of the NF is sufficient and does not raise safety concerns. The applicant proposed to use the NF as a food supplement for the general adult population, excluding pregnant women, at a maximum daily amount of 350 mg. Taking into account these conditions of use, the Panel considers that the consumption of the NF is not nutritionally disadvantageous. The provided genotoxicity studies do not raise concerns for genotoxicity of the NF. Based on the findings of a subchronic toxicity study, supported by a subacute toxicity study, the Panel identified the overall no observed adverse effect level (NOAEL) of the NF at 100 mg/kg body weight (bw) per day. By applying an uncertainty factor of 200, the Panel concludes that the NF is safe at an intake level of 0.5 mg/kg bw per day, corresponding to a maximum daily intake of 35 mg of the NF for the target population, i.e. adults excluding pregnant women. (C) 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. Non
- Published
- 2020