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104. Hematopoietic stem cells are acutely sensitive to ACD shelterin gene inactivation

Author

Jones, Morgan, Osawa, Gail, Regal, Joshua, Weinberg, Daniel, Taggart, James, Kocak, Hande, Friedman, Ann, Ferguson, David, Keegan, Catherine, and Maillard, Ivan

Subjects
Gene expression -- Physiological aspects -- Research, Hematopoietic stem cells -- Physiological aspects -- Genetic aspects -- Research, Telomerase -- Physiological aspects -- Genetic aspects -- Research, Health care industry
Abstract

The shelterin complex plays dual functions in telomere homeostasis by recruiting telomerase and preventing the activation of a DNA damage response at telomeric ends. Somatic stem cells require telomerase activity, as evidenced by progressive stem cell loss leading to bone marrow failure in hereditary dyskeratosis congenita. Recent work demonstrates that dyskeratosis congenita can also arise from mutations in specific shelterin genes, although little is known about shelterin functions in somatic stem cells. We found that mouse hematopoietic stem cells (HSCs) are acutely sensitive to inactivation of the shelterin gene Acd, encoding TPP1. Homozygosity for a hypomorphic acd allele preserved the emergence and expansion of fetal HSCs but led to profoundly defective function in transplantation assays. Upon complete Acd inactivation, HSCs expressed p53 target genes, underwent cell cycle arrest, and were severely depleted within days, leading to hematopoietic failure. TPP1 loss induced increased telomeric fusion events in bone marrow progenitors. However, unlike in epidermal stem cells, p53 deficiency did not rescue TPP1-deficient HSCs, indicating that shelterin dysfunction has unique effects in different stem cell populations. Because the consequences of telomere shortening are progressive and unsynchronized, acute loss of shelterin function represents an attractive alternative for studying telomere crisis in hematopoietic progenitors., Introduction Linear chromosomes are capped with telomeres to protect their ends from the loss of genetic material during strand replication. Disruptions in the stability of this molecular buffer have been [...]

Published
2014
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106. Real World Survival Outcomes of CPX-351 Versus Venetoclax and Azacitadine for Initial Therapy in Adult Acute Myeloid Leukemia

Author

Matthews, Andrew, primary, Perl, Alexander E., additional, Luger, Selina M., additional, Babushok, Daria V., additional, Frey, Noelle V, additional, Gill, Saar, additional, Hexner, Elizabeth O., additional, Martin, Mary Ellen, additional, McCurdy, Shannon R., additional, Porter, David L., additional, Stadtmauer, Edward A., additional, Loren, Alison W., additional, Paralkar, Vikram R, additional, Maillard, Ivan, additional, Margolis, David, additional, and Pratz, Keith W., additional

Published
2021
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107. Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

Author

Graniel, Jacqueline V, primary, Bisht, Kamlesh, additional, Friedman, Ann, additional, White, James, additional, Perkey, Eric, additional, Vanderbeck, Ashley, additional, Moroz, Alina, additional, Carrington, Léolène J, additional, Brandstadter, Joshua D, additional, Allen, Frederick, additional, Shami, Adrienne Niederriter, additional, Thomas, Peedikayil, additional, Crayton, Aniela, additional, Manzor, Mariel, additional, Mychalowych, Anna, additional, Chase, Jennifer, additional, Hammoud, Saher S, additional, Keegan, Catherine E, additional, Maillard, Ivan, additional, and Nandakumar, Jayakrishnan, additional

Published
2021
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110. Blockade of individual Notch ligands and receptors controls graft-versus-host disease

Author

Tran, Ivy T., Sandy, Ashley R., Carulli, Alexis J., Ebens, Christen, Chung, Jooho, Shan, Gloria T., Radojcic, Vedran, Friedman, Ann, Gridley, Thomas, Shelton, Amy, Reddy, Pavan, Samuelson, Linda C., Yan, Minhong, Siebel, Christian W., and Maillard, Ivan

Subjects
T cells -- Research -- Physiological aspects, Bone marrow -- Transplantation, Graft versus host reaction -- Risk factors -- Prevention, Proteins -- Research -- Physiological aspects, Health care industry
Abstract

Graft-versus-host disease (GVHD) is the main complication of allogeneic bone marrow transplantation. Current strategies to control GVHD rely on global immunosuppression. These strategies are incompletely effective and decrease the anticancer [...]

Published
2013
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112. Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

Author

Graniel, Jacqueline V., primary, Bisht, Kamlesh, additional, Friedman, Ann, additional, White, James, additional, Perkey, Eric, additional, Vanderbeck, Ashley, additional, Moroz, Alina, additional, Carrington, Léolène J., additional, Brandstadter, Joshua D., additional, Allen, Frederick, additional, Shami, Adrienne Niederriter, additional, Thomas, Peedikayil, additional, Crayton, Aniela, additional, Manzor, Mariel, additional, Mychalowych, Anna, additional, Chase, Jennifer, additional, Hammoud, Saher S., additional, Keegan, Catherine E., additional, Maillard, Ivan, additional, and Nandakumar, Jayakrishnan, additional

Published
2021
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113. CD8

Author

Bange, Erin M., Han, Nicholas A., Wileyto, Paul, Kim, Justin Y., Gouma, Sigrid, Robinson, James, Greenplate, Allison R., Hwee, Madeline A., Porterfield, Florence, Owoyemi, Olutosin, Naik, Karan, Zheng, Cathy, Galantino, Michael, Weisman, Ariel R., Ittner, Caroline A.G., Kugler, Emily M., Baxter, Amy E., Oniyide, Olutwatosin, Agyekum, Roseline S., Dunn, Thomas G., Jones, Tiffanie K., Giannini, Heather M., Weirick, Madison E., McAllister, Christopher M., Babady, N. Esther, Kumar, Anita, Widman, Adam J., DeWolf, Susan, Boutemine, Sawsan R., Roberts, Charlotte, Budzik, Krista R, Tollett, Susan, Wright, Carla, Perloff, Tara, Sun, Lova, Mathew, Divij, Giles, Josephine R., Oldridge, Derek A., Wu, Jennifer E., Alanio, Cécile, Adamski, Sharon, Garfall, Alfred L., Vella, Laura A, Kerr, Samuel J., Cohen, Justine V., Oyer, Randall A., Massa, Ryan, Maillard, Ivan P., Maxwell, Kara N., Reilly, John P., Maslak, Peter G., Vonderheide, Robert H., Wolchok, Jedd D., Hensley, Scott E., Wherry, E. John, Meyer, Nuala J., DeMichele, Angela M., Vardhana, Santosha A., Mamtani, Ronac, and Huang, Alexander C.

Subjects
Male, B-Lymphocytes, Immunity, Cellular, SARS-CoV-2, COVID-19, CD8-Positive T-Lymphocytes, Middle Aged, Antibodies, Viral, Article, Immunity, Humoral, Immunophenotyping, Cohort Studies, Survival Rate, Logistic Models, Hematologic Neoplasms, Neoplasms, Multivariate Analysis, Humans, Female, Prospective Studies, Aged, Proportional Hazards Models
Abstract

Cancer patients have increased morbidity and mortality from Coronavirus Disease 2019 (COVID-19), but the underlying immune mechanisms are unknown. In a cohort of 100 cancer patients hospitalized for COVID-19 at the University of Pennsylvania Health System, we found that patients with hematologic cancers had a significantly higher mortality relative to patients with solid cancers after accounting for confounders including ECOG performance status and active cancer status. We performed flow cytometric and serologic analyses of 106 cancer patients and 113 non-cancer controls from two additional cohorts at Penn and Memorial Sloan Kettering Cancer Center. Patients with solid cancers exhibited an immune phenotype similar to non-cancer patients during acute COVID-19 whereas patients with hematologic cancers had significant impairment of B cells and SARS-CoV-2-specific antibody responses. High dimensional analysis of flow cytometric data revealed 5 distinct immune phenotypes. An immune phenotype characterized by CD8 T cell depletion was associated with a high viral load and the highest mortality of 71%, among all cancer patients. In contrast, despite impaired B cell responses, patients with hematologic cancers and preserved CD8 T cells had a lower viral load and mortality. These data highlight the importance of CD8 T cells in acute COVID-19, particularly in the setting of impaired humoral immunity. Further, depletion of B cells with anti-CD20 therapy resulted in almost complete abrogation of SARS-CoV-2-specific IgG and IgM antibodies, but was not associated with increased mortality compared to other hematologic cancers, when adequate CD8 T cells were present. Finally, higher CD8 T cell counts were associated with improved overall survival in patients with hematologic cancers. Thus, CD8 T cells likely compensate for deficient humoral immunity and influence clinical recovery of COVID-19. These observations have important implications for cancer and COVID-19-directed treatments, immunosuppressive therapies, and for understanding the role of B and T cells in acute COVID-19.

Published
2021

115. Comparing Cairo Bishop and Howard Criteria for Identifying Clinically Meaningful Tumor Lysis Syndrome Among Acute Myeloid Leukemia Patients Treated with Venetoclax and Hypomethylating Agents: A Single Center Experience

Author

Rowe, Margaret, Babushok, Daria V, Carroll, Martin, Carulli, Alison, Frey, Noelle V., Gill, Saar, Hexner, Elizabeth O, Hirsh, Rebecca, Hossain, Nasheed, Lai, Catherine, Loren, Alison W, Luger, Selina M, Maillard, Ivan, McCurdy, Shannon R, Matthews, Andrew H, Martin, Mary Ellen, Paralkar, Vikram R, Perl, Alexander, Porter, David L., Pratz, Keith W, Stadtmauer, Edward A., and Jordan Bruno, Ximena

Published
2023
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116. Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

Author

Bandyopadhyay, Shovik, Duffy, Michael, Ahn, Kyung Jin, Pang, Minxing, Smith, David, Duncan, Gwendolyn, Sussman, Jonathan, Zhang, Jihan, Huang, Jeffrey, Lin, Yulieh, Xiong, Barbara, Imtiaz, Tamjid, Chen, Chia Hui, Thadi, Anusha, Chen, Changya, Xu, Jason, Reichart, Melissa, Pillai, Vinodh, Snaith, Oraine, Oldridge, Derek, Bhattacharyya, Siddharth, Maillard, Ivan, Carroll, Martin, Nelson, Charles, Qin, Ling, and Tan, Kai

Published
2023
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117. Stroma-Driven Notch2 Signaling Controls Naïve B Cell Fate By Regulating Microenvironmental Positioning within the Spleen

Author

Allman, Anneka, Gaudette, Brian, Kelly, Samantha, Alouche, Nagham, Carrington, Leolene, Perkey, Eric, Outen, Riley, Vanderbeck, Ashley, Lederer, Katlyn, Robertson, Tanner F., Burkhardt, Janis K., Tikhonova, Anastasia N., Aifantis, Iannis, Koch, Ute, Radtke, Freddy, Ludewig, Burkhard, Tveriakhina, Lena, Gossler, Achim, Siebel, Christian W., Gomez Atria, Daniela, Luther, Sanjiv, Allman, David, and Maillard, Ivan

Published
2023
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121. BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation

Author

Jia, Wei, primary, Poe, Jonathan C., additional, Su, Hsuan, additional, Anand, Sarah, additional, Matsushima, Glenn K., additional, Rathmell, Jeffrey C., additional, Maillard, Ivan, additional, Radojcic, Vedran, additional, Imai, Kazuhiro, additional, Reyes, Nancy J., additional, Cardona, Diana M., additional, Li, Zhiguo, additional, Suthers, Amy N., additional, Curry-Chisolm, Itaevia M., additional, DiCioccio, Rachel A., additional, Saban, Daniel R., additional, Chen, Benny J., additional, Chao, Nelson J., additional, and Sarantopoulos, Stefanie, additional

Published
2021
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122. Stroma-derived Notch signals drive transdifferentiation of follicular B cells into marginal zone B cells during lymphopenia

Author

Atria, Daniela Gomez, primary, Londregan, Jennifer, additional, Gaudette, Brian T., additional, Perkey, Eric, additional, Kelly, Samantha, additional, Ludewig, Burkhard, additional, Siebel, Christian W., additional, Ryan, Russell J. H., additional, Pear, Warren S., additional, Allman, David, additional, and Maillard, Ivan, additional

Published
2021
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124. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics

Author

Serrano-Lopez, Juana, primary, Hegde, Shailaja, additional, Kumar, Sachin, additional, Serrano, Josefina, additional, Fang, Jing, additional, Wellendorf, Ashley M, additional, Roche, Paul A, additional, Rangel, Yamileth, additional, Carrington, Leolene J, additional, Geiger, Hartmut, additional, Grimes, H Leighton, additional, Luther, Sanjiv, additional, Maillard, Ivan, additional, Sanchez-Garcia, Joaquin, additional, Starczynowski, Daniel T, additional, and Cancelas, Jose A, additional

Published
2021
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126. Author response: Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics

Author

Serrano-Lopez, Juana, primary, Hegde, Shailaja, additional, Kumar, Sachin, additional, Serrano, Josefina, additional, Fang, Jing, additional, Wellendorf, Ashley M, additional, Roche, Paul A, additional, Rangel, Yamileth, additional, Carrington, Leolene J, additional, Geiger, Hartmut, additional, Grimes, H Leighton, additional, Luther, Sanjiv, additional, Maillard, Ivan, additional, Sanchez-Garcia, Joaquin, additional, Starczynowski, Daniel T, additional, and Cancelas, Jose A, additional

Published
2021
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127. Notch-Regulated Dendritic Cells Restrain Inflammation-Associated Colorectal Carcinogenesis

Author

Wang, Lei, primary, Yu, Shuiliang, additional, Chan, Ernest R., additional, Chen, Kai-Yuan, additional, Liu, Cui, additional, Che, Danian, additional, Awadallah, Amad, additional, Myers, Jay, additional, Askew, David, additional, Huang, Alex Y., additional, Maillard, Ivan, additional, Huang, Dan, additional, Xin, Wei, additional, and Zhou, Lan, additional

Published
2021
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128. Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers

Author

Abella, Benjamin S., Jolkovsky, Eliana L., Biney, Barbara T., Uspal, Julie E., Hyman, Matthew C., Frank, Ian, Hensley, Scott E., Gill, Saar, Vogl, Dan T., Maillard, Ivan, Babushok, Daria V., Huang, Alexander C., Nasta, Sunita D., Walsh, Jennifer C., Wiletyo, E. Paul, Gimotty, Phyllis A., Milone, Michael C., and Amaravadi, Ravi K.

Subjects
Adult, Male, Cross Infection, SARS-CoV-2, Research, Incidence, COVID-19, Pennsylvania, COVID-19 Drug Treatment, Personnel, Hospital, Hospitals, Urban, Double-Blind Method, Internal Medicine, Online First, Humans, Female, Pre-Exposure Prophylaxis, Original Investigation, Hydroxychloroquine
Abstract

Key Points Question Does a regimen of hydroxychloroquine, 600 mg, per day, reduce the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a pre-exposure prophylaxis strategy when taken by hospital-based health care workers? Finding In this double-blind, placebo-controlled randomized clinical trial that included 132 participants and was terminated early, there was not a significant difference in reverse-transcriptase polymerase chain reaction–confirmed SARS-CoV-2 incidence between hydroxychloroquine and placebo cohorts. Meaning Among hospital-based health care workers, daily hydroxychloroquine did not prevent SARS-CoV-2 infection, although the trial was terminated early and may have been underpowered to detect a clinically important difference., Importance Health care workers (HCWs) caring for patients with coronavirus disease 2019 (COVID-19) are at risk of exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, to our knowledge, there is no effective pharmacologic prophylaxis for individuals at risk. Objective To evaluate the efficacy of hydroxychloroquine to prevent transmission of SARS-CoV-2 in hospital-based HCWs with exposure to patients with COVID-19 using a pre-exposure prophylaxis strategy. Design, Setting, and Participants This randomized, double-blind, placebo-controlled clinical trial (the Prevention and Treatment of COVID-19 With Hydroxychloroquine Study) was conducted at 2 tertiary urban hospitals, with enrollment from April 9, 2020, to July 14, 2020; follow-up ended August 4, 2020. The trial randomized 132 full-time, hospital-based HCWs (physicians, nurses, certified nursing assistants, emergency technicians, and respiratory therapists), of whom 125 were initially asymptomatic and had negative results for SARS-CoV-2 by nasopharyngeal swab. The trial was terminated early for futility before reaching a planned enrollment of 200 participants. Interventions Hydroxychloroquine, 600 mg, daily, or size-matched placebo taken orally for 8 weeks. Main Outcomes and Measures The primary outcome was the incidence of SARS-CoV-2 infection as determined by a nasopharyngeal swab during the 8 weeks of treatment. Secondary outcomes included adverse effects, treatment discontinuation, presence of SARS-CoV-2 antibodies, frequency of QTc prolongation, and clinical outcomes for SARS-CoV-2–positive participants. Results Of the 132 randomized participants (median age, 33 years [range, 20-66 years]; 91 women [69%]), 125 (94.7%) were evaluable for the primary outcome. There was no significant difference in infection rates in participants randomized to receive hydroxychloroquine compared with placebo (4 of 64 [6.3%] vs 4 of 61 [6.6%]; P > .99). Mild adverse events were more common in participants taking hydroxychloroquine compared with placebo (45% vs 26%; P = .04); rates of treatment discontinuation were similar in both arms (19% vs 16%; P = .81). The median change in QTc (baseline to 4-week evaluation) did not differ between arms (hydroxychloroquine: 4 milliseconds; 95% CI, −9 to 17; vs placebo: 3 milliseconds; 95% CI, −5 to 11; P = .98). Of the 8 participants with positive results for SARS-CoV-2 (6.4%), 6 developed viral symptoms; none required hospitalization, and all clinically recovered. Conclusions and Relevance In this randomized clinical trial, although limited by early termination, there was no clinical benefit of hydroxychloroquine administered daily for 8 weeks as pre-exposure prophylaxis in hospital-based HCWs exposed to patients with COVID-19. Trial Registration ClinicalTrials.gov Identifier: NCT04329923, This randomized clinical trial evaluates the efficacy of hydroxychloroquine to prevent transmission of SARS-CoV-2 in health care workers with exposure to patients with COVID-19 at 2 hospitals in Philadelphia, Pennsylvania.

Published
2020

131. CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer

Author

Bange, Erin, primary, Han, Nicholas, additional, Wileyto, E. Paul, additional, Kim, Justin, additional, Gouma, Sigrid, additional, Robinson, James, additional, Greenplate, Allison, additional, Porterfield, Florence, additional, Owoyemi, Olutosin, additional, Naik, Karan, additional, Zheng, Cathy, additional, Galantino, Michael, additional, Weisman, Ariel, additional, Ittner, Carolin, additional, Kugler, Emily, additional, Baxter, Amy, additional, Weirick, Madison, additional, McAllister, Christopher, additional, Babady, Ngolela Esther, additional, Kumar, Anita, additional, Widman, Adam, additional, Dewolf, Susan, additional, Boutemine, Sawsan, additional, Roberts, Charlotte, additional, Budzik, Krista, additional, Tollett, Susan, additional, Wright, Carla, additional, Perloff, Tara, additional, Sun, Lova, additional, Mathew, Divij, additional, Giles, Josephine, additional, Oldridge, Derek, additional, Wu, Jennifer, additional, Alanio, Cecile, additional, Adamski, Sharon, additional, Vella, Laura, additional, Kerr, Samuel, additional, Cohen, Justine, additional, Oyer, Randall, additional, Massa, Ryan, additional, Maillard, Ivan, additional, Maxwell, Kara, additional, Maslak, Peter, additional, Vonderheide, Robert, additional, Wolchok, Jedd D., additional, Hensley, Scott, additional, Wherry, E., additional, Meyer, Nuala, additional, DeMichele, Angela, additional, Oniyide, Oluwatosin, additional, Agyekum, Roseline, additional, Dunn, Thomas, additional, Jones, Tiffanie, additional, Giannini, Heather, additional, Garfall, Alfred, additional, Reilly, John, additional, Vardhana, Santosha, additional, Mamtani, Ronac, additional, and Huang, Alexander, additional

Published
2021
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132. Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics

Author

Serrano-Lopez, Juana, primary, Hegde, Shailaja, additional, Kumar, Sachin, additional, Serrano, Josefina, additional, Fang, Jing, additional, Wellendorf, Ashley M., additional, Roche, Paul A., additional, Rangel, Yamileth, additional, Carrington, Léolène J., additional, Geiger, Hartmut, additional, Grimes, H. Leighton, additional, Luther, Sanjiv, additional, Maillard, Ivan, additional, Sanchez-Garcia, Joaquin, additional, Starczynowski, Daniel T., additional, and Cancelas, Jose A., additional

Published
2021
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133. SARS-CoV-2 seropositivity and seroconversion in patients undergoing active cancer-directed therapy

Author

Sun, Lova, primary, Surya, Sanjna, additional, Goodman, Noah G., additional, Le, Anh N., additional, Kelly, Gregory, additional, Owoyemi, Olutosin, additional, Desai, Heena, additional, Zheng, Cathy, additional, DeLuca, Shannon, additional, Good, Madeline L., additional, Hussain, Jasmin, additional, Jeffries, Seth D., additional, Kry, Yolanda R., additional, Kugler, Emily M., additional, Mansour, Maikel, additional, Ndicu, John, additional, Osei-Akoto, AnnaClaire, additional, Prior, Timothy, additional, Pundock, Stacy L., additional, Varughese, Lisa A., additional, Weaver, JoEllen, additional, Doucette, Abigail, additional, Dudek, Scott, additional, Verma, Shefali Setia, additional, Gouma, Sigrid, additional, Weirick, Madison E., additional, McAllister, Christopher M., additional, Bange, Erin, additional, Gabriel, Peter, additional, Ritchie, Marylyn, additional, Rader, Daniel J., additional, Vonderheide, Robert H., additional, Schuchter, Lynn M, additional, Verma, Anurag, additional, Maillard, Ivan, additional, Mamtani, Ronac, additional, Hensley, Scott E., additional, Gross, Robert, additional, Wileyto, E. Paul, additional, Huang, Alexander C., additional, Maxwell, Kara N., additional, and DeMichele, Angela, additional

Published
2021
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134. Rates of COVID-19–Related Outcomes in Cancer Compared With Noncancer Patients

Author

Sun, Lova, primary, Surya, Sanjna, additional, Le, Anh N, additional, Desai, Heena, additional, Doucette, Abigail, additional, Gabriel, Peter, additional, Ritchie, Marylyn D, additional, Rader, Daniel, additional, Maillard, Ivan, additional, Bange, Erin, additional, Huang, Alexander C, additional, Vonderheide, Robert H, additional, DeMichele, Angela, additional, Verma, Anurag, additional, Mamtani, Ronac, additional, and Maxwell, Kara N, additional

Published
2021
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135. SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

Author

Lederer, Katlyn, primary, Castaño, Diana, additional, Gómez Atria, Daniela, additional, Oguin, Thomas H., additional, Wang, Sidney, additional, Manzoni, Tomaz B., additional, Muramatsu, Hiromi, additional, Hogan, Michael J., additional, Amanat, Fatima, additional, Cherubin, Patrick, additional, Lundgreen, Kendall A., additional, Tam, Ying K., additional, Fan, Steven H.Y., additional, Eisenlohr, Laurence C., additional, Maillard, Ivan, additional, Weissman, Drew, additional, Bates, Paul, additional, Krammer, Florian, additional, Sempowski, Gregory D., additional, Pardi, Norbert, additional, and Locci, Michela, additional

Published
2020
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139. Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Author

Paz, Katelyn, Flynn, Ryan, Du, Jing, Qi, Jun, Luznik, Leo, Maillard, Ivan, MacDonald, Kelli P., Hill, Geoffrey R., Serody, Jonathan S., Murphy, William J., Sage, Peter T., Sharpe, Arlene H., Miklos, David, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Bradner, James E., Melnick, Ari M., and Blazar, Bruce R.

Published
2019
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140. Stromal Notch Ligands Drive Notch2-Dependent Transdifferentiation of Follicular B Cells into Marginal Zone-like B Cells in Lymphopenic Environments

Author

Gómez Atria, Daniela, primary, Gaudette, Brian T., additional, Perkey, Eric, additional, Londregan, Jennifer, additional, Kelly, Samantha, additional, Ludewig, Burkhard, additional, Siebel, Chris, additional, Ryan, Russell J. H., additional, Pear, Warren S., additional, Allman, David, additional, and Maillard, Ivan, additional

Published
2020
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141. Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

Author

Parker, Kevin R., primary, Migliorini, Denis, additional, Perkey, Eric, additional, Yost, Kathryn E., additional, Bhaduri, Aparna, additional, Bagga, Puneet, additional, Haris, Mohammad, additional, Wilson, Neil E., additional, Liu, Fang, additional, Gabunia, Khatuna, additional, Scholler, John, additional, Montine, Thomas J., additional, Bhoj, Vijay G., additional, Reddy, Ravinder, additional, Mohan, Suyash, additional, Maillard, Ivan, additional, Kriegstein, Arnold R., additional, June, Carl H., additional, Chang, Howard Y., additional, Posey, Avery D., additional, and Satpathy, Ansuman T., additional

Published
2020
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142. Rates of COVID-19-related Outcomes in Cancer compared to non-Cancer Patients

Author

Sun, Lova, primary, Surya, Sanjna, additional, Le, Anh N., additional, Desai, Heena, additional, Doucette, Abigail, additional, Gabriel, Peter, additional, Ritchie, Marylyn, additional, Rader, Daniel, additional, Maillard, Ivan, additional, Bange, Erin, additional, Huang, Alexander, additional, Vonderheide, Robert H., additional, DeMichele, Angela, additional, Verma, Anurag, additional, Mamtani, Ronac, additional, and Maxwell, Kara N., additional

Published
2020
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144. Sa1159 NOTCH2 SIGNALING REGULATES DENDRITIC CELLS TO LIMIT INFLAMMATION-ASSOCIATED COLON CARCINOGENESIS

Author

Wang, Lei, primary, Yu, Shuiliang, additional, Liu, Cui, additional, Wang, Weihuan, additional, Che, Danian, additional, Li, Luoyi, additional, Myers, Jay, additional, Askew, David, additional, Chan, Ernest R., additional, Huang, Alex, additional, Maillard, Ivan, additional, Ivanov, Ivaylo, additional, Xin, Wei, additional, and Zhou, Lan, additional

Published
2020
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147. Inhibiting fatty acid synthesis (FAS) can prevent and treat chronic graft versus host disease (cGVHD)

Author

Aguilar, Ethan George, primary, Rhee, Stephanie, additional, Thangavelu, Govindarajan, additional, Loschi, Michael, additional, Paz, Katelyn, additional, Saha, Asim, additional, Ly, Joanna, additional, Sage, Peter, additional, Sharpe, Arlene H, additional, Maillard, Ivan, additional, Murphy, William J, additional, Serody, Jonathan S, additional, Jin, Suji, additional, Wagers, Sara Bolivar, additional, Nicholls, Jemma, additional, Hill, Geoffrey, additional, MacDonald, Kelli PA, additional, Compeer, Ewoud, additional, Dustin, Michael, additional, O’Connor, Roddy, additional, Sparwasser, Tim, additional, and Blazar, Bruce R, additional

Published
2020
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148. GCNT1-Mediated O-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells

Author

Perkey, Eric, primary, Maurice De Sousa, Dave, additional, Carrington, Léolène, additional, Chung, Jooho, additional, Dils, Alexander, additional, Granadier, David, additional, Koch, Ute, additional, Radtke, Freddy, additional, Ludewig, Burkhard, additional, Blazar, Bruce R., additional, Siebel, Christian W., additional, Brennan, Todd V., additional, Nolz, Jeffrey, additional, Labrecque, Nathalie, additional, and Maillard, Ivan, additional

Published
2020
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150. Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

Author

Klossowski, Szymon, primary, Miao, Hongzhi, additional, Kempinska, Katarzyna, additional, Wu, Tao, additional, Purohit, Trupta, additional, Kim, EunGi, additional, Linhares, Brian M., additional, Chen, Dong, additional, Jih, Gloria, additional, Perkey, Eric, additional, Huang, Huang, additional, He, Miao, additional, Wen, Bo, additional, Wang, Yi, additional, Yu, Ke, additional, Lee, Stanley Chun-Wei, additional, Danet-Desnoyers, Gwenn, additional, Trotman, Winifred, additional, Kandarpa, Malathi, additional, Cotton, Anitria, additional, Abdel-Wahab, Omar, additional, Lei, Hongwei, additional, Dou, Yali, additional, Guzman, Monica, additional, Peterson, Luke, additional, Gruber, Tanja, additional, Choi, Sarah, additional, Sun, Duxin, additional, Ren, Pingda, additional, Li, Lian-Sheng, additional, Liu, Yi, additional, Burrows, Francis, additional, Maillard, Ivan, additional, Cierpicki, Tomasz, additional, and Grembecka, Jolanta, additional

Published
2020
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