364 results on '"Leemhuis, Aleid G."'
Search Results
102. Restricted Ventilation Associated with Reduced Neurodevelopmental Impairment in Preterm Infants
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Vliegenthart, Roseanne J.S., primary, Onland, Wes, additional, van Wassenaer-Leemhuis, Aleid G., additional, De Jaegere, Anne P.M., additional, Aarnoudse-Moens, Cornelieke S.H., additional, and van Kaam, Anton H., additional
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- 2017
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103. Minor neurological dysfunction in five year old very preterm children is associated with lower processing speed
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Kurpershoek, Tinka, primary, Potharst-Sirag, Eva S., additional, Aarnoudse-Moens, Cornelieke S.H., additional, and van Wassenaer-Leemhuis, Aleid G., additional
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- 2016
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104. Maternal and Paternal Perception of Child Vulnerability and Behaviour Problems in Very Preterm Born Children
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Potharst, Eva S., Houtzager, Bregje A., van Wassenaer-Leemhuis, Aleid G., Kok, Joke H., Koot, Hans M., Last, Bob F., Child and Adolescent Psychiatry & Psychosocial Care, Other Research, and Neonatology
- Abstract
Preterm born children have more behaviour problems than term born children. Perinatal risks, current child functioning, sociodemographic characteristics, parental psychological distress and parental perceptions of child vulnerability (PCV) have been shown to be risk factors for behaviour problems. However, the role of maternal and paternal PCV is unclear, as these have not been investigated as a risk factor for behaviour problems, with all other risk factors taken into account. Aim of this study is to investigate whether maternal and paternal PCV are independent risk factors for behaviour problems in very preterm (VP) and term born children. The present study is a single centre prospective cohort study. Preterm children (n=104), born at
- Published
- 2015
105. Rethinking preventive post-discharge intervention programmes for very preterm infants and their parents.
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Wassenaer-Leemhuis, Aleid G, Jeukens-Visser, Martine, Hus, Janeline W P, Meijssen, Dominique, Wolf, Marie-Jeanne, Kok, Joke H, Nollet, Frans, Koldewijn, Karen, van Wassenaer-Leemhuis, Aleid G, and van Hus, Janeline W P
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PREMATURE infants , *HOSPITAL admission & discharge , *RANDOMIZED controlled trials , *COGNITION , *PARENT-child relationships , *HEALTH outcome assessment , *PREMATURE infants -- Hospital care , *CHILD development , *FAMILY psychotherapy , *PARENTING , *PREVENTIVE health services , *SYSTEMATIC reviews - Abstract
Post-discharge preventive intervention programmes with involvement of the parent may support the resilience and developmental outcomes of infants born very preterm. Randomized controlled trials of home-based family-centred intervention programmes in very preterm infants that aimed to improve cognitive outcome, at least at age two, were selected and updated on the basis of a recent systematic review to compare their content and effect over time to form the basis of a narrative review. Six programmes were included in this narrative review. Four of the six programmes led to improved child cognitive and/or motor development. Two programmes, which focused primarily on responsive parenting and development, demonstrated improved cognitive outcome up till 5 years after completion of the programme. The programmes that also focused on maternal anxiety remediation led to improved maternal mental well-being, along with improved child behaviour, in one study - even at 3 years after completion of the programme. The magnitude of the effects was modest. Family-centred preventive intervention programmes that aim at improvement of child development should be continued after discharge home to improve the preterm child's resilience. Programmes may be most effective when they support the evolvement of a responsive parent-infant relationship over time, as well as the parent's well-being. [ABSTRACT FROM AUTHOR]
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- 2016
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106. Long-Term Neurodevelopmental Outcome after Doxapram for Apnea of Prematurity
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ten Hove, Christine H., primary, Vliegenthart, Roseanne J., additional, te Pas, Arjan B., additional, Brouwer, Emma, additional, Rijken, Monique, additional, van Wassenaer-Leemhuis, Aleid G., additional, van Kaam, Anton H., additional, and Onland, Wes, additional
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- 2016
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107. 531: Long-term effects of cervical pessary for preterm birth prevention in twin pregnancy with short cervix: a 3 years follow-up of the ProTwin trial
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van 't Hooft, Janneke, primary, Cuijpers, Cuny, additional, van der Lee, Johanna H., additional, Liem, Sophie, additional, Schuit, Ewoud, additional, Opmeer, Brent C., additional, Steenis, Leonie, additional, van Wassenaer-Leemhuis, Aleid G., additional, van Baar, Anneloes L., additional, Bekedam, Dick, additional, Mol, Ben Willem J., additional, and van der Beek, Cornelieke, additional
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- 2016
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108. The ages and stages questionnaire and neurodevelopmental impairment in two-year-old preterm-born children
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Kerstjens, Jorien M., Nijhuis, Ard, Hulzebos, Christian V., Van Imhoff, Deirdre E., Van Wassenaer-Leemhuis, Aleid G., Van Haastert, Ingrid C., Lopriore, Enrico, Katgert, Titia, Swarte, Renate M., Van Lingen, Richard A., Mulder, Twan L., Laarman, Céleste R., Steiner, Katerina, Dijk, Peter H., Kerstjens, Jorien M., Nijhuis, Ard, Hulzebos, Christian V., Van Imhoff, Deirdre E., Van Wassenaer-Leemhuis, Aleid G., Van Haastert, Ingrid C., Lopriore, Enrico, Katgert, Titia, Swarte, Renate M., Van Lingen, Richard A., Mulder, Twan L., Laarman, Céleste R., Steiner, Katerina, and Dijk, Peter H.
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- 2015
109. Preventing Preterm Birth with Progesterone in Women with a Short Cervical Length from a Low-Risk Population : A Multicenter Double-Blind Placebo-Controlled Randomized Trial
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van Os, Melanie A, van der Ven, A Jeanine, Kleinrouweler, C Emily, Schuit, Ewoud, Kazemier, Brenda M, Verhoeven, Corine J, de Miranda, Esteriek, van Wassenaer-Leemhuis, Aleid G, Sikkema, J Marko, Woiski, Mallory D, Bossuyt, Patrick M, Pajkrt, Eva, de Groot, Christianne J M, Mol, Ben Willem J, Haak, Monique C, van Os, Melanie A, van der Ven, A Jeanine, Kleinrouweler, C Emily, Schuit, Ewoud, Kazemier, Brenda M, Verhoeven, Corine J, de Miranda, Esteriek, van Wassenaer-Leemhuis, Aleid G, Sikkema, J Marko, Woiski, Mallory D, Bossuyt, Patrick M, Pajkrt, Eva, de Groot, Christianne J M, Mol, Ben Willem J, and Haak, Monique C
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- 2015
110. Behavioural and neurodevelopmental outcome of 2-year-old children after preterm premature rupture of membranes: follow-up of a randomised clinical trial comparing induction of labour and expectant management
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Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Der Heyden, Jantien L., Willekes, Christine, Van Baar, Anneloes L., Van Wassenaer-leemhuis, Aleid G., Pajkrt, Eva, Oudijk, Martijn A., Porath, Martina M., Duvekot, Hans (j) J., Bloemenkamp, Kitty W.m., Groenewout, Mariette, Woiski, Mallory, Nij Bijvank, Bas, Bax, Caroline J., Van 't Hooft, Janneke, Sikkema, Marko (j) M., Akerboom, Bettina M.c., Mulder, Twan (a) L.m., Nijhuis, Jan G., Mol, Ben Willem J., Van Der Ham, David P., Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Der Heyden, Jantien L., Willekes, Christine, Van Baar, Anneloes L., Van Wassenaer-leemhuis, Aleid G., Pajkrt, Eva, Oudijk, Martijn A., Porath, Martina M., Duvekot, Hans (j) J., Bloemenkamp, Kitty W.m., Groenewout, Mariette, Woiski, Mallory, Nij Bijvank, Bas, Bax, Caroline J., Van 't Hooft, Janneke, Sikkema, Marko (j) M., Akerboom, Bettina M.c., Mulder, Twan (a) L.m., Nijhuis, Jan G., Mol, Ben Willem J., and Van Der Ham, David P.
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- 2015
111. The ages and stages questionnaire and neurodevelopmental impairment in two-year-old preterm-born children
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Brain, Kerstjens, Jorien M., Nijhuis, Ard, Hulzebos, Christian V., Van Imhoff, Deirdre E., Van Wassenaer-Leemhuis, Aleid G., Van Haastert, Ingrid C., Lopriore, Enrico, Katgert, Titia, Swarte, Renate M., Van Lingen, Richard A., Mulder, Twan L., Laarman, Céleste R., Steiner, Katerina, Dijk, Peter H., Brain, Kerstjens, Jorien M., Nijhuis, Ard, Hulzebos, Christian V., Van Imhoff, Deirdre E., Van Wassenaer-Leemhuis, Aleid G., Van Haastert, Ingrid C., Lopriore, Enrico, Katgert, Titia, Swarte, Renate M., Van Lingen, Richard A., Mulder, Twan L., Laarman, Céleste R., Steiner, Katerina, and Dijk, Peter H.
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- 2015
112. Behavioural and neurodevelopmental outcome of 2-year-old children after preterm premature rupture of membranes: Follow-up of a randomised clinical trial comparing induction of labour and expectant management
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Other research (not in main researchprogram), Geboortecentrum voorzitterschap, Child Health, Van Der Heyden, Jantien L., Willekes, Christine, Van Baar, Anneloes L., Van Wassenaer-Leemhuis, Aleid G., Pajkrt, Eva, Oudijk, Martijn A., Porath, Martina M., Duvekot, Hans J., Bloemenkamp, Kitty W M, Groenewout, Mariette, Woiski, Mallory, Nij Bijvank, Bas, Bax, Caroline J., Van 'T Hooft, Janneke, Sikkema, Marko M., Akerboom, Bettina M C, Mulder, Twan L M, Nijhuis, Jan G., Mol, Ben Willem J, Van Der Ham, David P., Other research (not in main researchprogram), Geboortecentrum voorzitterschap, Child Health, Van Der Heyden, Jantien L., Willekes, Christine, Van Baar, Anneloes L., Van Wassenaer-Leemhuis, Aleid G., Pajkrt, Eva, Oudijk, Martijn A., Porath, Martina M., Duvekot, Hans J., Bloemenkamp, Kitty W M, Groenewout, Mariette, Woiski, Mallory, Nij Bijvank, Bas, Bax, Caroline J., Van 'T Hooft, Janneke, Sikkema, Marko M., Akerboom, Bettina M C, Mulder, Twan L M, Nijhuis, Jan G., Mol, Ben Willem J, and Van Der Ham, David P.
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- 2015
113. Preventing Preterm Birth with Progesterone in Women with a Short Cervical Length from a Low-Risk Population: A Multicenter Double-Blind Placebo-Controlled Randomized Trial
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Epi Methoden Team 1, van Os, Melanie A, van der Ven, A Jeanine, Kleinrouweler, C Emily, Schuit, Ewoud, Kazemier, Brenda M, Verhoeven, Corine J, de Miranda, Esteriek, van Wassenaer-Leemhuis, Aleid G, Sikkema, J Marko, Woiski, Mallory D, Bossuyt, Patrick M, Pajkrt, Eva, de Groot, Christianne J M, Mol, Ben Willem J, Haak, Monique C, Epi Methoden Team 1, van Os, Melanie A, van der Ven, A Jeanine, Kleinrouweler, C Emily, Schuit, Ewoud, Kazemier, Brenda M, Verhoeven, Corine J, de Miranda, Esteriek, van Wassenaer-Leemhuis, Aleid G, Sikkema, J Marko, Woiski, Mallory D, Bossuyt, Patrick M, Pajkrt, Eva, de Groot, Christianne J M, Mol, Ben Willem J, and Haak, Monique C
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- 2015
114. Effect of socioeconomic status on psychosocial problems in 5- to 6-year-old preterm- and term-born children: the ABCD study
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de Laat, Sanne A. A., primary, Essink-Bot, Marie-Louise, additional, van Wassenaer-Leemhuis, Aleid G., additional, and Vrijkotte, Tanja G., additional
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- 2015
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115. The Ages and Stages Questionnaire and Neurodevelopmental Impairment in Two-Year-Old Preterm-Born Children
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Kerstjens, Jorien M., primary, Nijhuis, Ard, additional, Hulzebos, Christian V., additional, van Imhoff, Deirdre E., additional, van Wassenaer-Leemhuis, Aleid G., additional, van Haastert, Ingrid C., additional, Lopriore, Enrico, additional, Katgert, Titia, additional, Swarte, Renate M., additional, van Lingen, Richard A., additional, Mulder, Twan L., additional, Laarman, Céleste R., additional, Steiner, Katerina, additional, and Dijk, Peter H., additional
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- 2015
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116. A functional approach to cerebral visual impairments in very preterm/very-low-birth-weight children
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Geldof, Christiaan J.A., primary, van Wassenaer-Leemhuis, Aleid G., additional, Dik, Marjolein, additional, Kok, Joke H., additional, and Oosterlaan, Jaap, additional
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- 2015
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117. Maternal and Paternal Perception of Child Vulnerability and Behaviour Problems in Very Preterm Born Children
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Potharst, Eva S., primary, Houtzager, Bregje A., additional, van Wassenaer-Leemhuis, Aleid G., additional, Kok, Joke H., additional, Koot, Hans M., additional, and Last, Bob F., additional
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- 2015
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118. Comparison of New Bronchopulmonary Dysplasia Definitions on Long-Term Outcomes in Preterm Infants.
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Katz, Trixie A., van Kaam, Anton H., Schuit, Ewoud, Mugie, Suzanne M., Aarnoudse-Moens, Cornelieke S.H., Weber, Elske H., de Groof, Femke, van Laerhoven, Henriette, Counsilman, Clare E., van der Schoor, Sophie R.D., Rijpert, Maarten, Schiering, Irene A., Wilms, Janneke, Leemhuis, Aleid G., and Onland, Wes
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- 2023
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119. Het STIPP-onderzoek
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Jeukens-Visser, Martine, primary, van Hus, J.W.P., additional, Koldewijn, Karen, additional, Meijssen, Dominique, additional, Verkerk, Gijs, additional, Nollet, Frans, additional, van Wassenaer-Leemhuis, Aleid G., additional, van Baar, Anneloes, additional, Kok, Joke, additional, and Wolf, Marie Jeanne, additional
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- 2014
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120. Visual search and attention in five-year-old very preterm/very low birth weight children
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Geldof, Christiaan J.A., primary, de Kieviet, Jorrit F., additional, Dik, Marjolein, additional, Kok, Joke H., additional, van Wassenaer-Leemhuis, Aleid G., additional, and Oosterlaan, Jaap, additional
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- 2013
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121. Motor impairment in very preterm-born children: links with other developmental deficits at 5 years of age
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Van Hus, Janeline W, primary, Potharst, Eva S, additional, Jeukens-Visser, Martine, additional, Kok, Joke H, additional, and Van Wassenaer-Leemhuis, Aleid G, additional
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- 2013
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122. Neonatal Gram Negative and Candida Sepsis Survival and Neurodevelopmental Outcome at the Corrected Age of 24 Months
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de Haan, Timo R., primary, Beckers, Loes, additional, de Jonge, Rogier C. J., additional, Spanjaard, Lodewijk, additional, van Toledo, Letty, additional, Pajkrt, Dasja, additional, van Wassenaer-Leemhuis, Aleid G., additional, and van der Lee, Johanna H., additional
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- 2013
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123. The capacity of mid-pregnancy cervical length to predict preterm birth in low-risk women: a national cohort study.
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Ven, Jeanine, Os, Melanie A., Kazemier, Brenda M., Kleinrouweler, Emily, Verhoeven, Corine J., Miranda, Esteriek, Wassenaer‐Leemhuis, Aleid G., Kuiper, Petra N., Porath, Martina, Willekes, Christine, Woiski, Mallory D., Sikkema, Marko J., Roumen, Frans J.M.E., Bossuyt, Patrick M., Haak, Monique C., Groot, Christianne J.M., Mol, Ben W.J., and Pajkrt, Eva
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ANTHROPOMETRY ,CERVIX uteri ,FETAL ultrasonic imaging ,PREMATURE infants ,LONGITUDINAL method ,SECOND trimester of pregnancy ,PROBABILITY theory ,PROGNOSIS ,PARITY (Obstetrics) ,RECEIVER operating characteristic curves - Abstract
Introduction: We investigated the predictive capacity of mid-trimester cervical length (CL) measurement for spontaneous and iatrogenic preterm birth.Material and Methods: We performed a prospective observational cohort study in nulliparous women and low-risk multiparous women with a singleton pregnancy between 16(+0) and 21(+6) weeks of gestation. We assessed the prognostic capacity of transvaginally measured mid-trimester CL for spontaneous and iatrogenic preterm birth (<37 weeks) using likelihood ratios (LR) and receiver-operating-characteristic analysis. We calculated numbers needed to screen to prevent one preterm birth assuming different treatment effects. Main outcome measures were preterm birth <32, <34 and <37 weeks.Results: We studied 11,943 women, of whom 666 (5.6%) delivered preterm: 464 (3.9%) spontaneous and 202 (1.7%) iatrogenic. Mean CL was 44.1 mm (SD 7.8 mm). In nulliparous women, the LRs for spontaneous preterm birth varied between 27 (95% CI 7.7-95) for a CL ≤ 20 mm, and 2.0 (95% CI 1.6-2.5) for a CL between 30 and 35 mm. For low-risk multiparous women, these LRs were 37 (95% CI 7.5-182) and 1.5 (95% CI 0.97-2.2), respectively. Using a cut-off for CL ≤ 30 mm, 28 (6.0%) of 464 women with spontaneous preterm birth were identified. The number needed to screen to prevent one case of preterm birth was 618 in nulliparous women and 1417 for low-risk multiparous women (40% treatment effect, cut-off 30 mm).Conclusion: In women at low risk of preterm birth, CL predicts spontaneous preterm birth. However, its isolated use as a screening tool has limited value due to low sensitivity. [ABSTRACT FROM AUTHOR]- Published
- 2015
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124. The Bilirubin Albumin Ratio in the Management of Hyperbilirubinemia in Preterm Infants to Improve Neurodevelopmental Outcome: A Randomized Controlled Trial – BARTrial.
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Hulzebos, Christian V., Dijk, Peter H., van Imhoff, Deirdre E., Bos, Arend F., Lopriore, Enrico, Offringa, Martin, Ruiter, Selma A. J., van Braeckel, Koen N. J. A., Krabbe, Paul F. M., Quik, Elise H., van Toledo-Eppinga, Letty, Nuytemans, Debbie H. G. M., van Wassenaer-Leemhuis, Aleid G., Benders, Manon J. N., Korbeeck-van Hof, Karen K. M., van Lingen, Richard A., Groot Jebbink, Liesbeth J. M., Liem, Djien, Mansvelt, Petri, and Buijs, Jan
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BILIRUBIN ,ALBUMINS ,HYPERBILIRUBINEMIA ,PREMATURE infant diseases ,HEALTH outcome assessment ,NEUROTOXICOLOGY ,RANDOMIZED controlled trials - Abstract
Background and Objective: High bilirubin/albumin (B/A) ratios increase the risk of bilirubin neurotoxicity. The B/A ratio may be a valuable measure, in addition to the total serum bilirubin (TSB), in the management of hyperbilirubinemia. We aimed to assess whether the additional use of B/A ratios in the management of hyperbilirubinemia in preterm infants improved neurodevelopmental outcome. Methods: In a prospective, randomized controlled trial, 615 preterm infants of 32 weeks' gestation or less were randomly assigned to treatment based on either B/A ratio and TSB thresholds (consensus-based), whichever threshold was crossed first, or on the TSB thresholds only. The primary outcome was neurodevelopment at 18 to 24 months' corrected age as assessed with the Bayley Scales of Infant Development III by investigators unaware of treatment allocation. Secondary outcomes included complications of preterm birth and death. Results: Composite motor (100±13 vs. 101±12) and cognitive (101±12 vs. 101±11) scores did not differ between the B/A ratio and TSB groups. Demographic characteristics, maximal TSB levels, B/A ratios, and other secondary outcomes were similar. The rates of death and/or severe neurodevelopmental impairment for the B/A ratio versus TSB groups were 15.4% versus 15.5% (P = 1.0) and 2.8% versus 1.4% (P = 0.62) for birth weights ≤1000 g and 1.8% versus 5.8% (P = 0.03) and 4.1% versus 2.0% (P = 0.26) for birth weights of >1000 g. Conclusions: The additional use of B/A ratio in the management of hyperbilirubinemia in preterm infants did not improve their neurodevelopmental outcome. Trial Registration: Controlled-Trials.com ISRCTN74465643 [ABSTRACT FROM AUTHOR]
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- 2014
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125. Somatosensory Evoked Potentials in Very Preterm Infants in Relation To Thyroxine Supplementation 1139
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Smit, Bert J, primary, van Wassenaer-Leemhuis, Aleid G, additional, Kok, Joke H, additional, de Vries, Linda S, additional, and de Vijlder, Jan JM, additional
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- 1998
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126. MOTOR NERVE CONDUCTION VELOCITY IN VERY PRETERM INFANTS IN RELATION TO THYROXINE SUPPLEMENTATION † 1057
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SMIT, BERT J, primary, Van Wassenaer-Leemhuis, ALEID G, additional, KOK, JOKE H, additional, De VRIES, LINDA S, additional, and De VIJLDER, JAN JM, additional
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- 1997
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127. Visual sensory and perceptive functioning in 5-year-old very preterm/very-low-birthweight children.
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Geldof, Christiaan Ja, Oosterlaan, Jaap, Vuijk, Pieter Jelle, de Vries, Meindert J, Kok, Joke H, and van Wassenaer-Leemhuis, Aleid G
- Abstract
AIM: To examine visual sensory and perceptive functions, study their interrelations, and explore associations between visual dysfunctions and intelligence in very preterm/very-low-birthweight (VP/VLBW) children. METHOD: One-hundred and sixteen VP/VLBW children (57 males, 59 females; mean gestational age 30.1wks, SD 2.3; mean corrected age 5y 6mo, SD 1mo) and 73 term-born children (40 males, 33 females; mean gestational age 39.9wks, SD 1.3; mean age 5y 6mo, SD 3mo) completed visual sensory (acuity, visual field, contrast-, color-, and stereovision), perceptive (visual coherence, and Developmental Test of Visual Perception non-motor scale), and intelligence assessments. RESULTS: Compared with term-born children, VP/VLBW children had reduced acuity (d=0.70, p<0.001), inferior visual field (d=0.67, p<0.001), and stereovision (v=0.19, p=0.008). VP/VBLW children showed weaker static coherence (d=0.49, p=0.001) and Position in Space (d=0.41, p=0.006) performance, independent of visual sensory deficits, and showed lower Verbal IQ (VIQ) and Performance IQ (PIQ; p<0.001). Visual perceptive functioning accounted for 13% of variance in VIQ, and for 35% of variance in PIQ. INTERPRETATION: Visual sensory and perceptive dysfunctions are present in VP/VLBW children and occur largely independently of each other. Visual perceptive dysfunctions are moderately associated with PIQ, and weakly with VIQ. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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128. Doppler ultrasound of umbilical and middle cerebral artery in third trimester small‐for‐gestational age fetuses to decide on timing of delivery for suspected fetal growth restriction: A cohort with nested RCT (DRIGITAT).
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Marijnen, Mauritia C., Kamphof, Hester D., Damhuis, Stefanie E., Smies, Maddy, Leemhuis, Aleid G., Wolf, Hans, Gordijn, Sanne J., Ganzevoort, Wessel, Schaaf, J. M., de Boer, M. A., Zwart, J. J., Huisjes, A. J. M., Veerbeek, J. H. W., van Laar, J. O. E. H., Al‐Nasiry, S., Bremer, H. A., Hermsen, B. B. J., van de Nieuwenhof, H. P., Sueters, M., and van der Ham, D. P.
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FETAL growth retardation , *DOPPLER ultrasonography , *CEREBRAL arteries , *SMALL for gestational age , *FETUS - Abstract
Objective: To assess the association of the umbilicocerebral ratio (UCR) with adverse perinatal outcome in late preterm small‐for‐gestational age (SGA) fetuses and to investigate the effect on perinatal outcomes of immediate delivery. Design: Multicentre cohort study with nested randomised controlled trial (RCT). Setting: Nineteen secondary and tertiary care centres. Population: Singleton SGA pregnancies (estimated fetal weight [EFW] or fetal abdominal circumference [FAC] <10th centile) from 32 to 36+6 weeks. Methods: Women were classified: (1) RCT‐eligible: abnormal UCR twice consecutive and EFW below the 3rd centile at/or below 35 weeks or below the 10th centile at 36 weeks; (2) abnormal UCR once or intermittent; (3) never abnormal UCR. Consenting RCT‐eligible patients were randomised for immediate delivery from 34 weeks or expectant management until 37 weeks. Main outcome measures: A composite adverse perinatal outcome (CAPO), defined as perinatal death, birth asphyxia or major neonatal morbidity. Results: The cohort consisted of 690 women. The study was halted prematurely for low RCT‐inclusion rates (n = 40). In the RCT‐eligible group, gestational age at delivery, birthweight and birthweight multiple of the median (MoM) (0.66, 95% confidence interval [CI] 0.59–0.72) were significantly lower and the CAPO (n = 50, 44%, p < 0.05) was more frequent. Among patients randomised for immediate delivery there was a near‐significant lower birthweight (p = 0.05) and higher CAPO (p = 0.07). EFW MoM, pre‐eclampsia, gestational hypertension and Doppler classification were independently associated with the CAPO (area under the curve 0.71, 95% CI 0.67–0.76). Conclusions: Perinatal risk was effectively identified by low EFW MoM and UCR. Early delivery of SGA fetuses with an abnormal UCR at 34–36 weeks should only be performed in the context of clinical trials. [ABSTRACT FROM AUTHOR]
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- 2024
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129. Maternal psychological distress after severe pregnancy hypertension was associated with increased child behavioural problems at the age of 12.
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Beukers, Fenny, Aarnoudse-Moens, Cornelieke S H, van Weissenbruch, Mirjam M, Ganzevoort, Wessel, van Goudoever, Johannes B, and van Wassenaer-Leemhuis, Aleid G
- Abstract
Aim: We examined the association between early maternal psychological distress after severe hypertensive disorders of pregnancy (HDP) and behavioural issues in their 12-year-old offspring.Methods: This secondary analyses of a prospective mother-child birth cohort focused on 95 women with severe HDP and their singleton offspring. The mothers were recruited during pregnancy from 2000 to 2003 in Amsterdam, the Netherlands. Maternal distress at child term age and three months post-term was measured using the Symptom Checklist-90. The Child Behaviour Checklist for six years to 18 years was used to quantify social and attention problems in their offspring at 12 years of age. Perinatal and neonatal risk factors were also analysed.Results: The children were born at a mean age of just under 32 weeks and 90% weighed below the 10th percentile. High psychological distress (score ≥133) affected 45% of the mothers at term age and 44% three months post-term. Child social problems were significantly associated with maternal distress at three months and were highest in cases of high maternal distress in combination with major neonatal morbidity. Child attention problems were associated with maternal anxiety at three months post-term.Conclusion: Early maternal psychological distress after severe maternal HDP was associated with childhood behavioural issues at the age of 12. [ABSTRACT FROM AUTHOR]- Published
- 2018
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130. Consensus Based Definition of Growth Restriction in the Newborn.
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Beune, Irene M., Bloomfield, Frank H., Ganzevoort, Wessel, Embleton, Nicholas D., Rozance, Paul J., van Wassenaer-Leemhuis, Aleid G., Wynia, Klaske, and Gordijn, Sanne J.
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Objective: To develop a consensus definition of growth restriction in the newborn that can be used clinically to identify newborn infants at risk and in research to harmonize reporting and definition in the current absence of a gold standard.Study Design: An international panel of pediatric leaders in the field of neonatal growth were invited to participate in an electronic Delphi procedure using standardized methods and predefined consensus rules. Responses were fed back at group-level and the list of participants was provided. Nonresponders were excluded from subsequent rounds. In the first round, variables were scored on a 5-point Likert scale; in subsequent rounds, inclusion of variables and cut-offs were determined with a 70% level of agreement. In the final round participants selected the ultimate algorithm.Results: In total, 57 experts participated in the first round; 79% completed the procedure. Consensus was reached on the following definition: birth weight less than the third percentile, or 3 out of the following: birth weight <10th percentile; head circumference <10th percentile; length <10th percentile; prenatal diagnosis of fetal growth restriction; and maternal pregnancy information.Conclusions: Consensus was reached on a definition for growth restriction in the newborn. This definition recognizes that infants with birth weights <10th percentile may not be growth restricted and that infants with birth weights >10th percentile can be growth restricted. This definition can be adopted in clinical practice and in clinical trials to better focus on newborns at risk, and is complementary to the previously determined definition of fetal growth restriction. [ABSTRACT FROM AUTHOR]- Published
- 2018
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131. Risk Factors for Neurodevelopmental Impairment at 2- and 5-Years Corrected Age in Preterm Infants with Established Bronchopulmonary Dysplasia.
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Katz, Trixie A., van Kaam, Anton H., Mugie, Suzanne M., Aarnoudse-Moens, Cornelieke S.H., de Groof, Femke, van Kempen, Anne A.M.W., van den Heuvel, Maria E. N, Vogelzang, Judith, Rijpert, Maarten, Schiering, Irene A., Koomen-Botman, Irene, Visser, Fenna, Leemhuis, Aleid G., and Onland, Wes
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PREMATURE infants , *BRONCHOPULMONARY dysplasia , *NEURAL development , *LOGISTIC regression analysis , *GESTATIONAL age - Abstract
Introduction: The objective of this study was to identify risk factors for neurodevelopmental impairment (NDI) at 2- and 5-years corrected age (CA) in a cohort of preterm infants with established bronchopulmonary dysplasia (BPD). Methods: This single-center retrospective cohort study included infants born between 2009 and 2016 at a gestational age (GA) <30 weeks with moderate or severe BPD at 36 weeks' postmenstrual age. Perinatal characteristics, (social) demographics, and comorbidities were collected from the electronic patient records. Odds ratios for NDI were calculated with univariate and multivariate logistic regression analyses adjusting for potential confounders. Results: Of the 602 eligible infants, 123 infants were diagnosed with BPD. NDI was present in 30.3% and 56.1% at 2- and 5-years CA, respectively. The only independent risk factors associated with NDI in the multivariate analyses were birthweight (adjusted odds ratio [aOR] 0.74, 95% CI 0.57–0.95; aOR 0.70, 95% CI 0.54–0.91, respectively), small for GA (SGA) (aOR 3.25, 95% CI 1.09–9.61; aOR 5.44, 95% CI 1.62–18.2, respectively) at both time points, and male gender at 5-years CA (OR 2.49, 95% CI 1.11–5.57). Conclusion: Birthweight and SGA are independent risk factors for NDI at 2- and 5-years CA and male gender at 5-years CA in preterm infants with BPD. In contrast, well-known other risk factors for NDI in the general population of preterm infants, such as GA, maternal education, and neonatal comorbidities were not independently associated with NDI. [ABSTRACT FROM AUTHOR]
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- 2024
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132. Fetal Growth Restriction with Brain Sparing: Neurocognitive and Behavioral Outcomes at 12 Years of Age.
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Beukers, Fenny, Aarnoudse-Moens, Cornelieke S.H., van Weissenbruch, Mirjam M., Ganzevoort, Wessel, van Goudoever, Johannes B., and van Wassenaer-Leemhuis, Aleid G.
- Abstract
Objective: To study neurocognitive functions and behavior in children with a history of fetal growth restriction (FGR) with brain sparing. We hypothesized that children with FGR would have poorer outcomes on these domains.Study Design: Subjects were 12-year-old children with a history of FGR born to mothers with severe early-onset hypertensive pregnancy disorders (n = 96) compared with a normal functioning full term comparison group with a birth weight ≥2500 g (n = 32). Outcome measures were neurocognitive outcomes (ie, intelligence quotient, executive function, attention) and behavior.Results: For the FGR group, the mean ratio of the pulsatility index for the umbilical artery/middle cerebral artery (UC-ratio = severity of brain sparing) was 1.42 ± 0.69. The mean gestational age was 31-6/7 ± 2-2/7 weeks. The mean birth weight was 1341 ± 454 g, and the mean birth weight ratio 0.68 ± 0.12. Neurocognitive outcomes were comparable between groups. Parents of children with FGR reported more social problems (mean T-score 56.6 ± 7.7; comparison 52.3 ± 4.3, P < .001, effect size = 1, 95% CI 0.52-1.46) and attention problems (mean T-score 57.3 ± 6.9; comparison 53.6 ± 4.2, P = .004, effect size = 0.88, 95% CI 0.42-1.33). UC-ratio was not associated with any of the outcomes, but low parental education and lower birth weight ratio were.Conclusions: In this prospective follow-up study of 12-year-old children with a history of FGR and confirmed brain sparing, neurocognitive functions were comparable with the comparison group, but parent-reported social and attention problem scores were increased. [ABSTRACT FROM AUTHOR]- Published
- 2017
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133. Gestational age and socio‐demographic factors associated with school performance at the age of 12 years, a population‐based study.
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Burger, Renée J., Roseboom, Tessa J., Ganzevoort, Wessel, Gordijn, Sanne J., Pajkrt, Eva, Abu‐Hanna, Ameen, Eskes, Martine, Leemhuis, Aleid G., Mol, Ben W., de Groot, Christianne J. M., and Ravelli, Anita C. J.
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PREMATURE infants , *GESTATIONAL age , *SOCIODEMOGRAPHIC factors , *POOR children , *PREMATURE labor , *MATERNAL age , *PRIMARY education - Abstract
Background: Gestational age is positively associated with cognitive development, but socio‐demographic factors also influence school performance. Previous studies suggested possible interaction, putting children with low socio‐economic status (SES) at increased risk of the negative effects of prematurity. Objectives: To investigate the association between gestational age in weeks, socio‐demographic characteristics, and school performance at the age of 12 years among children in regular primary education. Methods: Population‐based cohort study among liveborn singletons (N = 860,332) born in the Netherlands in 1999–2006 at 25–42 weeks' gestation, with school performance from 2011 to 2019. Regression analyses were conducted investigating the association of gestational age and sociodemographic factors with school performance and possible interaction. Results: School performance increased with gestational age up to 40 weeks. This pattern was evident across socio‐demographic strata. Children born at 25 weeks had −0.57 SD (95% confidence interval −0.79, −0.35) lower school performance z‐scores and lower secondary school level compared to 40 weeks. Low maternal education, low maternal age, and non‐European origin were strongly associated with lower school performance. Being born third or later and low socioeconomic status (SES) were also associated with lower school performance, but differences were smaller than among other factors. When born preterm, children from mothers with low education level, low or high age, low SES or children born third or later were at higher risk for lower school performance compared to children of mothers with intermediate education level, aged 25–29 years, with intermediate SES or first borns (evidence of interaction). Conclusions: Higher gestational age is associated with better school performance at the age of 12 years along the entire spectrum of gestational age, beyond the cut‐off of preterm birth and across socio‐demographic differences. Children in socially or economically disadvantaged situations might be more vulnerable to the negative impact of preterm birth. Other important factors in school performance are maternal education, maternal age, ethnicity, birth order and SES. Results should be interpreted with caution due to differential loss to follow‐up. [ABSTRACT FROM AUTHOR]
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- 2023
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134. Sustained developmental effects of the Infant Behavioral Assessment and Intervention Program in very low birth weight infants at 5.5 years.
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Hus, Janeline W.P., Jeukens-Visser, Martine, Koldewijn, Karen, Geldof, Christiaan J.A., Kok, Joke H., Wassenaer-Leemhuis, Aleid G., and Nollet, Frans
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- 2013
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135. Long-term health and neurodevelopment in children after antenatal exposure to low-dose aspirin for the prevention of preeclampsia and fetal growth restriction: A systematic review of randomized controlled trials.
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Landman, Anadeijda J.E.M.C., van Limburg Stirum, Emilie V.J., de Boer, Marjon A., van 't Hooft, Janneke, Ket, Johannes C.F., Leemhuis, Aleid G., Finken, Martijn J.J., Oudijk, Martijn A., and Painter, Rebecca C.
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NEURODEVELOPMENTAL treatment for infants , *FETAL growth retardation , *RANDOMIZED controlled trials , *ASPIRIN , *PERINATAL period , *PREECLAMPSIA , *BIRTH size , *HIV-positive women , *PREECLAMPSIA prevention , *CLINICAL trials , *SYSTEMATIC reviews , *LABOR (Obstetrics) - Abstract
Objective: To evaluate the long-term effects of antenatal aspirin exposure on child health and neurodevelopmental outcome beyond the perinatal period.Study Design: PubMed, Embase.com, the Cochrane Library and Web of Science were systematically searched from inception through 5 November 2020. We performed a cited-reference search and ClinicalTrials.gov was searched on 20 October 2020 to identify trial results that were not reported elsewhere. We included randomized controlled trials reporting on health-related outcomes in children (aged > 28 days) exposed to aspirin versus placebo or no treatment during pregnancy. Studies with any dose or duration of aspirin use were included. We excluded studies evaluating other antiplatelet agents or non-steroidal inflammatory drugs. Two authors independently performed study selection, data extraction and quality assessment. Quality assessment was performed using the Cochrane RoB2 tool for the original randomized controlled trials and the QUIPS for the follow-up studies. Results are presented as relative risks (RR) with 95% confidence intervals (95%CI).Results: The search yielded 6,907 unique records. Two studies were included, containing 4,168 children at age 12 months and 5,153 children at 18 months. Children were exposed to aspirin 50-60 mg versus placebo or no treatment. At 12 months, post-neonatal mortality was lower after allocation to aspirin (0.2% versus 0.5%; RR 0.28, 95%CI 0.08-0.99) in a single study. At 18 months, fewer children were found to have (gross and fine) motor problems (RR 0.49, 95%CI 0.26-0.91) after antenatal aspirin exposure in one study. No differences were found in mortality rate; the proportion of children with a short stature or low weight; or respiratory, hearing or visual problems at 18 months. Both included studies had a high risk of bias.Conclusion: The two included studies showed evidence of potential benefit of antenatal low-dose aspirin on mortality and neurodevelopment up to the age of 18 months. Our findings support the current application of low-dose aspirin in pregnant women at risk for preeclampsia and fetal growth restriction. However, further follow-up research of children who were exposed to low-dose aspirin during pregnancy is of utmost importance to exclude potential long-term harm. [ABSTRACT FROM AUTHOR]- Published
- 2021
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136. Maternal, perinatal and childhood outcomes of the PPROMEXIL-III cohort: Pregnancies complicated by previable prelabor rupture of membranes.
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Simons, Noor E., de Ruigh, Annemijn A., van der Windt, Larissa I., Kazemier, Brenda M., van Wassenaer-Leemhuis, Aleid G., van Teeffelen, Augustinus S., van Leeuwen, Elisabeth, Mol, Ben Willem, van 't Hooft, Janneke, and Pajkrt, Eva
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PREMATURE rupture of fetal membranes , *ABORTION , *CHILD death , *PERINATAL death , *LABOR (Obstetrics) , *PREGNANCY - Abstract
Objective: Perinatal mortality after previable prelabor rupture of membranes (previable PROM) might be underestimated as most studies exclude patients with poor prognosis, or solely include patients in tertiary-care centers. We aimed to report perinatal, neonatal and long-term outcomes in a consecutive series of women with pregnancies complicated by previable PROM.Study Design: We conducted a prospective cohort study including women with singleton pregnancies and previable PROM ≤ 23+6 weeks gestational age (GA) from one tertiary hospital and eight affiliated secondary hospitals in the region of Amsterdam, the Netherlands (June 2012 until January 2016, PPROMEXIL-III cohort). Exclusion criteria were signs of active labor before onset of PROM or fetal structural anomalies visible at ultrasound. We assessed perinatal mortality. Furthermore, outcomes were maternal, perinatal, neonatal and long-term child characteristics.Results: We included 98 pregnancies with previable PROM. Twelve women (12.2%) opted for termination of pregnancy, resulting in 86 pregnancies included in further analyses. Median GA at PROM was 20+2 weeks (interquartile range (IQR) 17+6-22+0). Median GA at delivery was 22+6 weeks (IQR 20+1-26+4). Delivery within 1 week occurred in 38.4% of women and 60.4% delivered before 24 weeks GA (viability). Perinatal mortality occurred in 73.3% of pregnancies. 23/33 (69.7%) live-born neonates survived to discharge, representing 26.7% of total. None of the children died after discharge. Developmental data at two and/or five years of age was available for 13/23 children (i.e. all children born before 32 weeks of gestation), with 69.2% of children reporting a normal neurodevelopment. However, more than half of children reported respiratory problems.Conclusion: In women with previable PROM perinatal mortality was 73.3%, with a normal neurodevelopment in 69.2% of surviving children with follow-up data. Due to broad inclusion criteria, this cohort represents a population more generalizable to daily practice as compared to previous studies. [ABSTRACT FROM AUTHOR]- Published
- 2021
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137. Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infection.
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van Ewijk, Roelof, Huibers, Minke H. W., Manshande, Meindert E., Ecury-Goossen, Ginette M., Duits, Ashley J., Calis, Job C., and van Wassenaer-Leemhuis, Aleid G.
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CHIKUNGUNYA , *COHORT analysis , *LONGITUDINAL method , *DISEASE complications , *INFANTS - Abstract
Background: Perinatally chikungunya infected neonates have been reported to have high rates of post-infection neurologic sequelae, mainly cognitive problems. In older children and adults chikungunya does not appear to have sequelae, but data on postnatally infected infants are lacking.Methods: We performed a prospective, non-controlled, observational study of infants infected before the age of 6 months with a severe chikungunya infection during the 2014-2015 epidemic in Curaçao, Dutch Antilles. Two years post-infection cognitive and motor - (BSID-III) and social emotional assessments (ITSEA) were performed.Results: Of twenty-two infected infants, two died and two were lost to follow up. Eighteen children were seen at follow-up and included in the current study. Of these, 13 (72%) had abnormal scores on the BSID-III (cognitive/motor) or ITSEA.Conclusion: In the first study aimed at postnatally infected infants, using an uncontrolled design, we observed a very high percentage of developmental problems. Further studies are needed to assess causality, however until these data are available preventive measure during outbreaks should also include young infants. Those that have been infected in early infancy should receive follow up. [ABSTRACT FROM AUTHOR]- Published
- 2021
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138. Follow-up and management of preterm prelabour rupture of membranes and preterm birth
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Simons, Noor E., Pajkrt, E., Roseboom, T.J., Leemhuis, A.G., van 't Hooft, Janneke, Faculteit der Geneeskunde, Pajkrt, Eva, Roseboom, Tessa J., Leemhuis, Aleid G., van Hooft, Jeanin E., Graduate School, ARD - Amsterdam Reproduction and Development, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, and Obstetrics and Gynaecology
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If the membranes rupture before 37 weeks of gestational age and without contractions, this is referred to as preterm prelabour rupture of membranes (PPROM). After PPROM there is a high chance of a preterm delivery and possible subsequent complications for the neonate. However, when delivery does not occur spontaneously and expectant management is pursued, the risk for an intra-amniotic infection is increased. This can also have neonatal and maternal complications. This thesis focusses on the treatment and prevention, and short-term and long-term developmental child outcomes of preterm prelabour rupture of membranes and preterm birth. The results of this thesis can be used by clinicians in daily clinical practice to inform pregnant women and their partners about these severe pregnancy complications and its sequelae. -- In de zwangerschap kunnen de vliezen prematuur breken (onder de 37 weken zwangerschapsduur) zonder dat aansluitend hierop weeën activiteit optreedt. Dit is gedefinieerd als preterm prelabour rupture of membranes, PPROM. Het prematuur breken van de vliezen gaat gepaard met een verhoogde kans op een intra-uteriene infectie, er is immers een open verbinding tussen de amnionholte en de buitenwereld. In ongeveer 30-40% van de gevallen zal na prematuur gebroken vliezen ook de bevalling op gang komen en leidt dit tot een vroeggeboorte (geboorte
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- 2023
139. Long-Term Effects of Oral Antidiabetic Drugs During Pregnancy on Offspring: A Systematic Review and Meta-analysis of Follow-up Studies of RCTs.
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van Weelden, Wenneke, Painter, Rebecca C., Wekker, Vincent, Roseboom, Tessa J., van Wassenaer-Leemhuis, Aleid G., de Wit, Leon, van Rijn, Bas B., Limpens, Jacqueline, Ijäs, Hilkka, and DeVries, J. Hans
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HEART metabolism disorders , *CHILD development , *GESTATIONAL diabetes , *INSULIN , *METFORMIN - Abstract
Introduction: Antidiabetic drugs (OADs) are increasingly prescribed to treat hyperglycaemia during pregnancy in women with gestational diabetes mellitus (GDM) or polycystic ovary syndrome (PCOS), even though long-term effects on offspring are unknown. This systematic review summarises the evidence of follow-up studies of randomised controlled trials (RCTs) reporting on long-term effects of prenatal exposure to OADs on offspring.Methods: The MEDLINE, EMBASE and CENTRAL databases were searched from inception to April 2018 for the concepts antidiabetic agents and prenatal exposure (or pregnancy and offspring/child) in combination with an RCT search filter. RCTs evaluating post-neonatal health effects in offspring and comparing maternal treatment with an OAD with no treatment, placebo, an alternative OAD or insulin during pregnancy were eligible for inclusion. Two independent researchers selected, extracted and assessed the data. Meta-analyses were performed using a random effects model and the Cochrane Collaboration’s risk of bias tool was used for quality assessment.Results: Ten studies were included, with a maximal follow-up duration of 9 years, comprising 778 children of mothers with GDM or PCOS who were randomised to either metformin or insulin/placebo during pregnancy. Meta-analysis showed that children prenatally exposed to metformin were heavier compared to controls (standardised mean difference (SMD) 0.26 [95% CI 0.11-0.41]), but not taller (SMD 0.10 [95% CI −0.14-0.33]). Additionally, offspring body mass index (BMI) z scores did not differ according to metformin exposure (mean difference 0.30 [95% CI −0.01-0.61]). Individual small studies reported that prenatal exposure to metformin was associated with greater mid-upper arm, head and waist circumferences, biceps skinfolds, waist-to-height ratio, more arm fat, higher fasting glucose, ferritin and lower LDL cholesterol in offspring.Conclusion: Prenatal exposure to metformin is associated with increased offspring weight, but not with height or BMI. Larger follow-up studies are needed to confirm and look into the implications of these findings.Plain Language Summary: Plain language summary available for this article. [ABSTRACT FROM AUTHOR]
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- 2018
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140. Very preterm children’s functioning at school-age: Is executive function training the solution?
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van Houdt, C.A., van Kaam, Anton H. L. C., Oosterlaan, Jaap, Aarnoudse-Moens, Cornelieke S. H., Leemhuis, Aleid G., Amsterdam Reproduction & Development, Graduate School, van Kaam, A.H.L.C., Oosterlaan, J., Aarnoudse-Moens, C.S.H., Leemhuis, A.G., and Faculteit der Geneeskunde
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This thesis aimed to examine (1) the severity of executive function (EF) deficits after preterm birth and potential risk factors for these deficits, (2) the effects of a computerized EF training in very preterm (VPT) children with attentional problems, (3) whether subtypes in behavioral functioning can be identified in VPT children and whether specific risk factors and/or neurocognitive functioning are associated with these subtypes and (4) developmental outcomes of VPT children with highly educated parents compared to term-born children with highly educated parents. Results of a meta-analysis indicated that VPT children have mild-to-moderate difficulties in all three core EFs, which have not decreased with recent advances in neonatal medical care, are similar for boys and girls and remain stable across childhood. Results of a double-blind RCT indicated that a computerized EF training does not have positive effects for VPT children with attentional problems. Results of a cross-sectional study indicated that two behavioral subtypes can be identified in VPT children, a low and a high problems subtype. The high problems subtype was associated with lower parental education level, lower IQ and poorer working memory and inhibition, but not to neonatal medical complications. Results of another cross-sectional study indicated that VPT children with highly educated parents perform below term-born children with highly educated parents on IQ and behavior, but not on academic performance. Furthermore, regardless of being born VPT or at term, children with two highly educated parents outperformed children with one highly and one middle educated parent on most measures.
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- 2020
141. Definition, management and prognosis in severe early-onset fetal growth restriction
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Pels, A., van der Post, Joris A. M., Ganzevoort, Wessel W., Leemhuis, Aleid G., Amsterdam Reproduction & Development, Graduate School, van der Post, J.A.M., Ganzevoort, J.W., Leemhuis, A.G., and Faculteit der Geneeskunde
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In severe early-onset fetal growth restriction (FGR), the fetus does not reach its genetic growth potential. Utero-placental insufficiency is the most common cause. FGR is associated with higher fetal mortality and long term child disabilities. Using meta-analysis, we found that 12% of pregnancies complicated by FGR result in antenatal death and 7% in neonatal death, but that only a few prospective studies reported the long-term neurodevelopment of the surviving children. We found an overall neurodevelopmental impairment rate of 11%. We added to that data a prospective study of 74 FGR children at five years, and found that 15% of the children had an abnormal IQ score and 38% had an abnormal motor score. Several issues in FGR management remain. First, heterogeneity exists in the definition of FGR and a uniform definition is necessary. Second, the optimal moment of delivery, usually by Doppler measurements and cardiotocography, is crucial in the balance between fetal and infant risks. We show that short term variation (STV) of the cardiotocography is not statistically significant associated with fetal acidemia, thus needs to be further investigated. Third, pregnant women with FGR have a high co-incidence with hypertensive disorders in pregnancy, but our analyses show that ‘tight’ control of hypertension probably is associated with a lower birthweight. In the search to find a possible treatment for FGR, the phosphodiesterase 5 inhibitor sildenafil was investigated in a placebo-controlled randomized controlled trial in 216 pregnant women with FGR. Sildenafil did not reduce the chance of neonatal mortality and morbidity. Moreover, an unexpected increase in neonatal pulmonary hypertension was observed, a finding that needs further investigation. Follow-up of the children born in this trial is underway. Sildenafil treatment is not the long hoped treatment to improve FGR pregnancies.
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- 2020
142. Very preterm children at early school age: Studies into assessment, development and support
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van Veen, S., van Kaam, Anton H. L. C., Oosterlaan, Jaap, Leemhuis, Aleid G., Aarnoudse - Moens, Cornelieke S. H., Graduate School, Amsterdam Reproduction & Development (AR&D), van Kaam, A.H.L.C., Oosterlaan, J., Leemhuis, A.G., Aarnoudse-Moens, C.S.H., and Faculteit der Geneeskunde
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The aims of this thesis were to unravel unresolved issues in the follow-up of very preterm children, and to provide insight in very preterm children’s support needs and their cognitive, motor and educational development at early school age. Two issues in follow-up described in the current thesis were correcting cognitive scores for prematurity and the effect of multilingualism on cognitive outcomes. Results showed that at the age of five years, there is still a significant difference between corrected and uncorrected IQ scores. Whether and up to what age to correct outcomes for prematurity should depend on the purpose and use of such outcomes. Results showed multilingualism to be negatively associated with cognitive outcomes in two- and five-year-old very preterm children. Exposing preterm children to two different languages at a young age might cause an overload of information, which might negatively affect their overall cognitive development. At preschool age a large proportion (61%) of very preterm children received health care therapies and/or educational support. The high proportion of children receiving support reinforces the idea that we need to have robust data to value the benefits, but also the burden of interventions for children, parents and society. At five years of age, we found that preschool mathematical skills were compromised, which could be explained by their visual-perceptive deficits. At eight years of age our results showed a substantial difference between verbal IQ and performance IQ which underlines the necessity to interpret both components separately.
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- 2019
143. Severe early-onset hypertensive disorders of pregnancy: A twelve year pediatric follow-up
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Beukers, Fenny, van Goudoever, J.B., Leemhuis, A.G., Ganzevoort, J.W., Faculteit der Geneeskunde, van Goudoever, Hans B., Leemhuis, Aleid G., Ganzevoort, Wessel W., Obstetrics and Gynaecology, Amsterdam Reproduction & Development, Graduate School, AGEM - Digestive immunity, and AGEM - Endocrinology, metabolism and nutrition
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Dit proefschrift gaat over de langetermijngevolgen van vroege en ernstige hypertensieve aandoeningen in de zwangerschap voor het kind. In dit onderzoeksproject bestudeerden we een cohort van kinderen geboren na vroege en ernstige hypertensieve aandoeningen in de zwangerschap, zoals pre-eclampsie en het HELLP syndroom. Kenmerkend voor deze groep kinderen is dat er veelal sprake is van ernstige groeivertraging bij de geboorte en dat de meeste kinderen te vroeg ofwel prematuur worden geboren. De kinderen werden tussen 2000 en 2003 geboren in het Academisch Medisch Centrum en het VU Medisch Centrum, Amsterdam. Op twaalfjarige leeftijd werden de kinderen en hun ouders onderzocht in het Academisch Medisch Centrum Amsterdam (het huidige Amsterdam UMC, locatie AMC). Er werd gekeken de groei, bloeddruk, cognitie en gedrag van het kind. Onze verwachting was dat kinderen geboren na vroege en ernstige hypertensieve aandoeningen in de zwangerschap problemen zouden hebben op al deze domeinen. Dit bleek echter niet zo te zijn. Wat betreft de groei en cognitie zagen we geen verschillen met Nederlandse leeftijdsgenoten. Wel rapporteerden ouders iets meer gedragsproblemen, te weten sociale en aandachtsproblemen. Dit leek met name het geval bij de kinderen waarvan de moeders veel stress hadden in de eerste drie maanden na thuiskomst uit het ziekenhuis. Wat betreft bloeddruk zagen we dat de kinderen die onder de 32 weken zwangerschapsduur waren geboren en de kinderen waarvan de moeder overgewicht had, een hogere bloeddruk hadden. In de discussie van dit proefschrift worden mogelijke verklaringen aangedragen voor de, niet verwachte, positieve resultaten, bespreken we de klinische implicaties van de studieresultaten, sterke en zwakke punten van het project en geven we suggesties voor vervolgonderzoek.
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- 2018
144. Neurodevelopment and the effects of a neurobehavioral intervention in very preterm-born children
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van Hus, Jacqueline Wilhelmine Petronella, van den Horn-Kok, Johanna H., Nollet, Frans, Jeukens-Visser, Martine, Leemhuis, Aleid G., and Rehabilitation
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- 2014
145. Long-term follow-up of obstetric studies
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Teune, Margreet J., Mol, Bernardus W. J., Opmeer, Brent C., Leemhuis, Aleid G., Amsterdam Public Health, and Obstetrics and Gynaecology
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- 2013
146. Suppoorting resilience in very preterm infants. The effect of the infant behavioral assessment and intervention program in very preterm infants
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Koldewijn, Karin, van den Horn-Kok, Johanna H., Nollet, Frans, Wolf-Vereecken, Marie Jeanne J. M. A. G., Leemhuis, Aleid G., and Rehabilitation
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- 2009
147. Impaired lung function and associated risk factors in children born prematurely: a systematic review and meta-analysis.
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van Boven MR, Hutten GJ, Richardson R, Königs M, Leemhuis AG, Onland W, Terheggen-Lagro SWJ, Oosterlaan J, and van Kaam AH
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- Humans, Risk Factors, Child, Forced Expiratory Volume, Infant, Newborn, Adolescent, Female, Male, Child, Preschool, Risk Assessment, Age Factors, Spirometry, Lung physiopathology, Infant, Premature, Gestational Age, Lung Diseases physiopathology, Lung Diseases diagnosis, Lung Diseases epidemiology
- Abstract
Background: Immature lung development and respiratory morbidity place preterm-born children at high risk of long-term pulmonary sequelae. This systematic review and meta-analysis aims to quantify lung function in preterm-born children and identify risk factors for a compromised lung function., Methods: We searched MEDLINE, Embase, Cochrane Library, Web of Science and Scopus for relevant studies published on preterm cohorts born since 1990. Studies comparing forced expiratory volume in 1 s (FEV
1 ) in preterm-born children aged ≥5 years to term-born controls or normative data were included. Study quality was assessed using the Newcastle-Ottawa Scale for cohort studies. Standardised mean differences in FEV1 and secondary spirometry outcomes per study were pooled using meta-analysis. The impact of different demographic and neonatal variables on studies' FEV1 effect sizes was investigated by meta-regression analyses. Certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations framework., Results: We identified 42 studies with unique cohorts including 4743 preterm children and 9843 controls. Median gestational age in the studies was 28.0 weeks and age at assessment ranged from 6.7 to 16.7 years. Preterm children had lower FEV1 than controls (-0.58 sd, 95% CI -0.69- -0.47 sd, p<0.001) resulting in a relative risk of 2.9 (95% CI 2.4-3.4) for abnormal outcome, with high certainty of evidence. FEV1 was significantly associated with gestational age, birthweight, bronchopulmonary dysplasia and invasive mechanical ventilation in univariate meta-regression analyses (R2 =36-96%)., Conclusion: This systematic review shows robust evidence of impaired lung function in preterm-born children with a high certainty of evidence., Competing Interests: Conflict of interest: M. Königs reports grants from GSK, KNVB and Daan Theeuwes Center for Intensive Neurorehabilitation, payment or honoraria for lectures, presentations, manuscript writing or educational events from Vrije Universiteit Amsterdam and Applied University for Physiotherapy SOMT, and their partner has stock options in Open Up BV, a psychological care provider. All other authors have nothing to disclose., (Copyright ©The authors 2024.)- Published
- 2024
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148. Atosiban versus placebo in the treatment of threatened preterm birth between 30 and 34 weeks gestation: study protocol of the 4-year APOSTEL 8 follow-up.
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van der Windt L, Klumper J, van Limburg Stirum EVJ, van 't Hooft J, van Wely M, van Wassenaer-Leemhuis AG, Pajkrt E, and Oudijk MA
- Subjects
- Humans, Female, Pregnancy, Double-Blind Method, Follow-Up Studies, Infant, Newborn, Child, Preschool, Gestational Age, Randomized Controlled Trials as Topic, Child Development drug effects, Multicenter Studies as Topic, Infant, Premature Birth prevention & control, Tocolytic Agents therapeutic use, Vasotocin analogs & derivatives, Vasotocin therapeutic use
- Abstract
Introduction: Currently, the majority of women worldwide with threatened preterm birth are treated with tocolytics. Although tocolytics can effectively delay birth for 48 hours, no tocolytic drug has convincingly been shown to improve neonatal outcomes and effects on long-term child development are unknown. The aim of this follow-up study of a placebo controlled randomised trial is to investigate the long-term effects of atosiban administration in case of threatened preterm birth on child's neurodevelopment and behaviour development, overall health and mortality., Methods and Analysis: This protocol concerns a follow-up study of the multicentre randomised double-blind placebo controlled APOSTEL 8 trial (NL61439.018.17, EudraCT-number 2017-001007-72). In this trial, women with threatened preterm birth (between 30 and 34 weeks of gestation) defined as uterine contractions with (1) a cervical length of <15 mm or (2) a cervical length of 15-30 mm and a positive fibronectin test or (3) in centres where cervical length measurement is not part of the local protocol: a positive fibronectin test or Actim-Partus test or (4) ruptured membranes, are randomised to atosiban or placebo for 48 hours. The primary outcome is a composite of perinatal mortality and severe neonatal morbidity. Children born to mothers who participated in the APOSTEL 8 study (n=760) will be eligible for follow-up at 4 years of corrected age and assessed using four parent-reported questionnaires. Primary outcomes are neurodevelopment and behaviour problems. Secondary outcomes are on child growth and general health. All outcomes will be compared between the atosiban and placebo group with OR and corresponding 95% CI. Analyses will be performed using the intention-to-treat approach., Ethics and Dissemination: The Medical Research Ethics Committee from Amsterdam UMC confirmed that de Medical Research Involving Human Subjects Act (Dutch WMO-law) did not apply to our study (W21_386 # 21.431). Results will be published in a peer-reviewed journal and shared with stakeholders and participants. This protocol is published before analysis of the results., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2024
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149. Association between bronchopulmonary dysplasia severity and its risk factors and long-term outcomes in three definitions: a historical cohort study.
- Author
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Katz TA, van Kaam AH, Zuithoff NPA, Mugie SM, Beuger S, Blok GJ, van Kempen AAMW, van Laerhoven H, Lutterman CAM, Rijpert M, Schiering IA, Ran NC, Visser F, van Straaten E, Aarnoudse-Moens CSH, van Wassenaer-Leemhuis AG, and Onland W
- Abstract
Objective: To compare the association of the severity categories of the 2001-National Institutes of Health (NIH), the 2018-NIH and the 2019-Jensen bronchopulmonary dysplasia (BPD) definitions with neurodevelopmental and respiratory outcomes at 2 and 5 years' corrected age (CA), and several BPD risk factors., Design: Single-centre historical cohort study with retrospective data collection., Setting: Infants born between 2009 and 2015 at the Amsterdam University Medical Centers, location Amsterdam Medical Center., Patients: Preterm infants born at gestational age (GA) <30 weeks and surviving up to 36 weeks' postmenstrual age., Interventions: Perinatal characteristics, (social) demographics and comorbidities were collected from the electronic patient records., Main Outcome Measures: The primary outcomes were neurodevelopmental impairment (NDI) or late death, and respiratory morbidity at 2 and 5 years' CA. Using logistic regression and Brier scores, we investigated if the ordinal grade severity is associated with incremental increase of adverse long-term outcomes., Results: 584 preterm infants (median GA: 28.1 weeks) were included and classified according to the three BPD definitions. None of the definitions showed a clear ordinal incremental increase of risk for any of the outcomes with increasing severity classification. No significant differences were found between the three BPD definitions (Brier scores 0.169-0.230). Respiratory interventions, but not GA, birth weight or small for GA, showed an ordinal relationship with BPD severity in all three BPD definitions., Conclusion: The severity classification of three BPD definitions showed low accuracy of the probability forecast on NDI or late death and respiratory morbidity at 2 and 5 years' CA, with no differences between the definitions., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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150. Identifying effect modifiers of systemic hydrocortisone treatment initiated 7-14 days after birth in ventilated very preterm infants on long-term outcome: secondary analysis of a randomised controlled trial.
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Halbmeijer NM, Sonnaert M, Swarte RM, Koopman-Esseboom C, van Stuijvenberg M, Mulder-de Tollenaer S, Tan RNGB, Mohns T, Bruneel E, Steiner K, Kramer BW, Debeer A, van Weissenbruch MM, Marechal Y, Blom H, Plaskie K, Offringa M, Merkus MP, Onland W, Leemhuis AG, and van Kaam AH
- Subjects
- Infant, Infant, Newborn, Humans, Hydrocortisone, Infant, Premature, Infant, Very Low Birth Weight, Glucocorticoids therapeutic use, Infant, Premature, Diseases drug therapy, Bronchopulmonary Dysplasia
- Abstract
Objective: To explore clinical effect modifiers of systemic hydrocortisone in ventilated very preterm infants for survival and neurodevelopmental outcome at 2 years' corrected age (CA)., Design: Secondary analysis of a randomised placebo-controlled trial., Setting: Dutch and Belgian neonatal intensive care units., Patients: Infants born <30 weeks' gestational age (GA), ventilator-dependent in the second week of postnatal life., Intervention: Infants were randomly assigned to systemic hydrocortisone (cumulative dose 72.5 mg/kg; n=182) or placebo (n=190)., Main Outcome Measures: The composite of death or neurodevelopmental impairment (NDI) at 2 years' CA and its components. Candidate effect modifiers (GA, small for GA, respiratory index, sex, multiple births, risk of moderate/severe bronchopulmonary dysplasia or death) were analysed using regression models with interaction terms and subpopulation treatment effect pattern plots., Results: The composite outcome was available in 356 (96.0%) of 371 patients (one consent withdrawn). For this outcome, treatment effect heterogeneity was seen across GA subgroups (<27 weeks: hydrocortisone (n=141) vs placebo (n=156), 54.6% vs 66.2%; OR 0.61 (95% CI 0.38 to 0.98); ≥27 weeks: hydrocortisone (n=30) vs placebo (n=31), 66.7% vs 45.2%; OR 2.43 (95% CI 0.86 to 6.85); p=0.02 for interaction). This effect was also found for the component death (<27 weeks: 20.1% vs 32.1%; OR 0.53 (95% CI 0.32 to 0.90); ≥27 weeks: 28.1% vs 16.1%; OR 2.04 (95% CI 0.60 to 6.95); p=0.049 for interaction) but not for the component NDI. No differential treatment effects were observed across other subgroups., Conclusion: This secondary analysis suggests that in infants <27 weeks' GA, systemic hydrocortisone may improve the outcome death or NDI, mainly driven by its component death. There was insufficient evidence for other selected candidate effect modifiers., Competing Interests: Competing interests: AHvK reports grants from the Netherlands Organization for Health Research and Development (ZonMW) during the conduct of the study. No other disclosures were reported., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2024
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