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561 results on '"Ju, Shaoqing"'

106. Antioxidant Properties of Quercetin

Author

Zhang, Mei, primary, Swarts, Steven G., additional, Yin, Liangjie, additional, Liu, Chaomei, additional, Tian, Yeping, additional, Cao, Yongbing, additional, Swarts, Michael, additional, Yang, Shanmin, additional, Zhang, Steven B., additional, Zhang, Kunzhong, additional, Ju, Shaoqing, additional, Olek, David J., additional, Schwartz, Lisa, additional, Keng, Peter C., additional, Howell, Rob, additional, Zhang, Lurong, additional, and Okunieff, Paul, additional

Published
2011
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107. Antioxidant Properties of Select Radiation Mitigators Based on Semicarbazone and Pyrazole Derivatives of Curcumin

Author

Swarts, Steven G., primary, Zhang, Mei, additional, Yin, Liangjie, additional, Liu, Chaomei, additional, Tian, Yeping, additional, Cao, Yongbing, additional, Swarts, Michael, additional, Olek, David J., additional, Schwartz, Lisa, additional, Zhang, Louie, additional, Yang, Shanmin, additional, Zhang, Steven B., additional, Zhang, Kunzhong, additional, Ju, Shaoqing, additional, Vidyasagar, Sadasivan, additional, Zhang, Lurong, additional, and Okunieff, Paul, additional

Published
2011
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125. Diagnostic Value of Circular RNA hsa_circ_0002874 Expression in Peripheral Blood of Patients with Gastric Cancer.

Author

Sun, Xiaoye, Kong, Shang, Jiang, Chen, Jing, Rongrong, Ju, Shaoqing, and Cong, Hui

Subjects
STOMACH tumors, CIRCULAR RNA, REVERSE transcriptase polymerase chain reaction, KRUSKAL-Wallis Test, EXOSOMES, BLOOD plasma, CASE-control method, METASTASIS, MANN Whitney U Test, CANCER patients, GENE expression, DESCRIPTIVE statistics, RESEARCH funding, TUMOR markers, RECEIVER operating characteristic curves, LYMPHOMAS, POLYMERASE chain reaction, DATA analysis software
Abstract

The purpose of this study was to determine whether circular RNA hsa_circ_0002874 could serve as a novel biomarker for the diagnosis of gastric cancer (GC). The expression level of hsa_circ_0002874 mean (interquartile range [IQR]) in the plasma of patients with GC, patients with benign gastric lesions, and healthy individuals was 3.482 (IQR, 1.524–9.048), 1.261 (IQR, 0.817–2.000), and 1.00 (IQR, 0.726–1.382), respectively, whereas there was no significant difference between the latter 2 groups. The plasma expression level of hsa_circ_0002874 was significantly correlated with tumor stage (U  = 234.0; P < .001) and lymph node metastasis (U  = 240.0; P < .001). The receiver operating characteristic (ROC) curve showed that the sensitivity of the combined determination of hsa_circ_0002874 and the serum markers CEA and CA19-9 was 95.8% in patients with GC compared with that of the healthy group and 93.0% compared with that of patients with benign gastric tumor lesions. The specificity of hsa_circ_0002874 in differentiating GC from benign lesions was 98.3%. The results showed that plasma hsa_circ_0002874 may prove to be a useful biomarker for auxiliary diagnosis, the grading of malignant neoplasms, and the prognostic prediction of GC. [ABSTRACT FROM AUTHOR]

Published
2022
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141. Circulating serum exosomal as a novel biomarker for early diagnosis of gastric cancer.

Author

Lu, Xu, Lu, Jianxin, Wang, Siqi, Zhang, Yu, Ding, Ye, Shen, Xianjuan, Jing, Rongrong, Ju, Shaoqing, Chen, Hongmei, and Cong, Hui

Abstract

Gastric cancer (GC) is one of the common malignant tumors with high mortality. The abundance of miRNAs in serum exosomes has proved to have a high application value as a new noninvasive diagnostic method. The purpose of this study was to investigate whether serum exosomal miR-92a-3p could be used as a new biomarker for early diagnosis of GC and evaluate its clinical application value by detecting the expression of serum exosomal miR-92a-3p in 131 patients with primary GC and 122 healthy controls by real-time quantitative (qRT)-PCR. The results showed that the expression level of serum exosomal miR-92a-3p in GC patients was significantly lower than that in normal controls (p < 0.0001). In addition, the level was closely correlated with lymph node metastasis and tumor node metastasis stage of GC patients. The area under the curve for serum exosomal miR-92a-3p was 0.829, significantly higher than for other indicators. Furthermore, combined detection of serum exosomal miR-92a-3p, CEA and CA19-9 was more sensitive than any of the three alone or any pair. These results showed that serum exosomal miR-92a-3p could be used as a novel new tumor biomarker to improve diagnostic efficiency in GC. [ABSTRACT FROM AUTHOR]

Published
2021
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