Back to Search
Start Over
Diagnostic Value of Circular RNA hsa_circ_0002874 Expression in Peripheral Blood of Patients with Gastric Cancer.
- Source :
- Laboratory Medicine; Jan2022, Vol. 53 Issue 1, p65-70, 6p
- Publication Year :
- 2022
-
Abstract
- The purpose of this study was to determine whether circular RNA hsa_circ_0002874 could serve as a novel biomarker for the diagnosis of gastric cancer (GC). The expression level of hsa_circ_0002874 mean (interquartile range [IQR]) in the plasma of patients with GC, patients with benign gastric lesions, and healthy individuals was 3.482 (IQR, 1.524–9.048), 1.261 (IQR, 0.817–2.000), and 1.00 (IQR, 0.726–1.382), respectively, whereas there was no significant difference between the latter 2 groups. The plasma expression level of hsa_circ_0002874 was significantly correlated with tumor stage (U = 234.0; P < .001) and lymph node metastasis (U = 240.0; P < .001). The receiver operating characteristic (ROC) curve showed that the sensitivity of the combined determination of hsa_circ_0002874 and the serum markers CEA and CA19-9 was 95.8% in patients with GC compared with that of the healthy group and 93.0% compared with that of patients with benign gastric tumor lesions. The specificity of hsa_circ_0002874 in differentiating GC from benign lesions was 98.3%. The results showed that plasma hsa_circ_0002874 may prove to be a useful biomarker for auxiliary diagnosis, the grading of malignant neoplasms, and the prognostic prediction of GC. [ABSTRACT FROM AUTHOR]
- Subjects :
- STOMACH tumors
CIRCULAR RNA
REVERSE transcriptase polymerase chain reaction
KRUSKAL-Wallis Test
EXOSOMES
BLOOD plasma
CASE-control method
METASTASIS
MANN Whitney U Test
CANCER patients
GENE expression
DESCRIPTIVE statistics
RESEARCH funding
TUMOR markers
RECEIVER operating characteristic curves
LYMPHOMAS
POLYMERASE chain reaction
DATA analysis software
Subjects
Details
- Language :
- English
- ISSN :
- 00075027
- Volume :
- 53
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 154542388
- Full Text :
- https://doi.org/10.1093/labmed/lmab062