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102. Incidence of cardiovascular events in patients with stabilized coronary heart disease: the EUROASPIRE IV follow-up study

Author

De Bacquer, Dirk, De Smedt, Delphine, Kotseva, Kornelia, Jennings, Catriona, Wood, David, Rydén, Lars, Gyberg, Viveca, Shahim, Bahira, Amouyel, Philippe, Bruthans, Jan, Castro Conde, Almudena, Cífková, Renata, Deckers, Jaap W., De Sutter, Johan, Dilic, Mirza, Dolzhenko, Maryna, Erglis, Andrejs, Fras, Zlatko, Gaita, Dan, Gotcheva, Nina, Goudevenos, John, Heuschmann, Peter, Laucevicius, Aleksandras, Lehto, Seppo, Lovic, Dragan, Miličić, Davor, Moore, David, Nicolaides, Evagoras, Oganov, Raphael, Pajak, Andrzej, Pogosova, Nana, Reiner, Zeljko, Stagmo, Martin, Störk, Stefan, Tokgözoğlu, Lale, Vulic, Dusko, Wagner, Martin, De Backer, Guy, and On behalf of the EUROASPIRE Investigators

Published
2019
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105. Development and proof-of-concept of a multicenter, patient-centered cancer registry for breast cancer patients with metastatic disease—the “Breast cancer care for patients with metastatic disease” (BRE-4-MED) registry

Author

Stangl, Stephanie, Haas, Kirsten, Eichner, Felizitas A., Grau, Anna, Selig, Udo, Ludwig, Timo, Fehm, Tanja, Stüber, Tanja, Rashid, Asarnusch, Kerscher, Alexander, Bargou, Ralf, Hermann, Silke, Arndt, Volker, Meyer, Martin, Wildner, Manfred, Faller, Hermann, Schrauder, Michael G., Weigel, Michael, Schlembach, Ulrich, Heuschmann, Peter U., and Wöckel, Achim

Published
2020
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109. Zusammenhang der Symptomkomplexe des Post-COVID-Syndrome (PCS) Scores mit seinen Prädiktoren Resilienz und akute Erkrankungsschwere: Subgruppenanalyse der populationsbezogenen COVIDOM-Studie (NAPKON-POP)

Author

Ballhausen, S, additional, Ruß, A, additional, Borzikowsky, C, additional, Lieb, W, additional, Horn, A, additional, Krist, L, additional, Fricke, J, additional, Rabe, K, additional, Maetzler, W, additional, Maetzler, C, additional, Laudien, M, additional, Frank, D, additional, Hermes, A, additional, Miljukov, O, additional, Häusler, K, additional, El Mokthari, N, additional, Witzenrath, M, additional, Vehreschild, J, additional, Krefting, D, additional, Pape, D, additional, Montellano, F, additional, Kohls, M, additional, Morbach, C, additional, Stoerk, S, additional, Reese, J, additional, Keil, T, additional, Heuschmann, P, additional, Schreiber, S, additional, Krawczak, M, additional, and Bahmer, T, additional

Published
2023
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110. Finale Ergebnisse: REDARES - Reduktion von Antibiotikaresistenzen durch leitliniengerechte Behandlung von Patientinnen mit unkompliziertem Harnwegsinfekt in der ambulanten Versorgung - eine randomisiert kontrollierte Studie

Author

Greser, A, Schmiemann, G, Heuschmann, P, Miljukov, O, Heintze, C, Schuster, A, Bleidorn, J, Eckmanns, T, Maun, A, Gágyor, I, Greser, A, Schmiemann, G, Heuschmann, P, Miljukov, O, Heintze, C, Schuster, A, Bleidorn, J, Eckmanns, T, Maun, A, and Gágyor, I

Published
2023

111. PreVitaCOV - Prednisolon und Vitamin B1, B6 und B12 bei Post-COVID: Erfahrungen nach einem halben Jahr Rekrutierung

Author

Tengelmann, C, Kaußner, Y, Förster, C, Lunden, L, Wildermuth, R, Zang, N, Eidenschink, C, Erdmann, K, Sellmann, S, Feil, E, Kutterer, C, Zolk, O, Hartung, K, Malzahn, U, Hügen, K, Heuschmann, P, Escales, C, Maetzler, W, Joos, S, Kaduszkiewicz, H, Gágyor, I, Tengelmann, C, Kaußner, Y, Förster, C, Lunden, L, Wildermuth, R, Zang, N, Eidenschink, C, Erdmann, K, Sellmann, S, Feil, E, Kutterer, C, Zolk, O, Hartung, K, Malzahn, U, Hügen, K, Heuschmann, P, Escales, C, Maetzler, W, Joos, S, Kaduszkiewicz, H, and Gágyor, I

Published
2023

112. Planung einer Interventionsstudie nach Arzneimittelgesetz in der Allgemeinmedizin: Erkenntnisse aus PreVitaCOV

Author

Lunden, L, Tengelmann, C, Kaußner, Y, Kutterer, C, Wildermuth, R, Zang, N, Eidenschink, C, Erdmann, K, Sellmann, S, Feil, E, Zolk, O, Malzahn, U, Hügen, K, Heuschmann, P, Escales, C, Maetzler, W, Joos, S, Kaduszkiewicz, H, Gágyor, I, Förster, C, Lunden, L, Tengelmann, C, Kaußner, Y, Kutterer, C, Wildermuth, R, Zang, N, Eidenschink, C, Erdmann, K, Sellmann, S, Feil, E, Zolk, O, Malzahn, U, Hügen, K, Heuschmann, P, Escales, C, Maetzler, W, Joos, S, Kaduszkiewicz, H, Gágyor, I, and Förster, C

Published
2023

119. EPH123 Estimating ADHD Prevalence and ADHD-Associated Health Care Costs Based on Claims Data

Author

Seck, K, primary, Witte, J, additional, Beyer, AK, additional, Schlack, R, additional, Neuperdt, L, additional, Hölling, H, additional, Kuhnert, R, additional, Romanos, M, additional, Jans, T, additional, Berner, A, additional, Hetzke, L, additional, Weyrich, S, additional, Hauer, D, additional, Scholz, V, additional, Ulsamer, S, additional, Wallau, C, additional, Ravens-Sieberer, U, additional, Kaman, A, additional, Gilbert, M, additional, Heuschmann, P, additional, Fiessler, C, additional, Horn, A, additional, Widmann, J, additional, and Riederer, C, additional

Published
2022
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121. Coagulation Testing in Intracerebral Hemorrhage Related to Non-vitamin K Antagonist Oral Anticoagulants

Author

Purrucker, Jan C., Rizos, Timolaos, Haas, Kirsten, Wolf, Marcel, Khan, Shujah, Heuschmann, Peter U., Veltkamp, Roland, Buchner, H., Ertl, M., Haarmeier, T., Hobohm, C., Jüttler, E., Neumann-Haefelin, T., Hennerici, M. G., Kleinschnitz, C., Köhrmann, M., Palm, F., Reinhard, M., Röther, J., Schellinger, P., Schmid, E., Seidel, G., Poli, S., Steiner, T., Tanislav, C., Thomalla, G., Veltkamp, R., Wartenberg, K., and on behalf of the RASUNOA investigators

Published
2017
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123. Secondary prevention in diabetic and nondiabetic coronary heart disease patients: Insights from the German subset of the hospital arm of the EUROASPIRE IV and V surveys

Author

Ungethüm, K., primary, Wiedmann, S., additional, Wagner, M., additional, Leyh, R., additional, Ertl, G., additional, Frantz, S., additional, Geisler, T., additional, Karmann, W., additional, Prondzinsky, R., additional, Herdeg, C., additional, Noutsias, M., additional, Ludwig, T., additional, Käs, J., additional, Klocke, B., additional, Krapp, J., additional, Wood, D., additional, Kotseva, K., additional, Störk, S., additional, and Heuschmann, P. U., additional

Published
2022
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124. Severity score-based study of predictors and clinical correlates of Post-COVID Syndrome (PCS) in Germany

Author

Bahmer, T, primary, Borzikowsky, C, additional, Lieb, W, additional, Horn, A, additional, Krist, L, additional, Fricke, J, additional, Scheibenbogen, C, additional, Rabe, K F, additional, Maetzler, W, additional, Maetzler, C, additional, Laudien, M, additional, Frank, D, additional, Ballhausen, S, additional, Viebke, A, additional, Hermes, A, additional, Muljukov, O, additional, Haeusler, K G, additional, El Mokhtari, N E, additional, Witzenrath, M, additional, Zoller, T, additional, Vehreschild, J J, additional, Hopff, S, additional, Anton, G, additional, Krefting, D, additional, Reinke, L, additional, Hein, G, additional, Montellano, F A, additional, Kohls, M, additional, Morbach, C, additional, Störk, S, additional, Reese, J, additional, Keil, T, additional, Heuschmann, P, additional, Krawczak, M, additional, and Schreiber, S, additional

Published
2022
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125. Das Projekt INTEGRATE-ADHD: Vergleich und Integration administrativer und epidemiologischer ADHS-Diagnosedaten durch klinisches Assessment bei Kindern und Jugendlichen in Deutschland

Author

Beyer, A-K, Schlack, R., Neuperdt, L., Kuhnert, R., Hoelling, H., Romanos, M., Jans, T., Berner, A., Hetzke, L., Weyrich, S., Emser, T., Hauer, D., Scholz, V, Ulsamer, S., Wallau, C., Ravens-Sieberer, U., Kaman, A., Gilbert, M., Greiner, Wolfgang, Witte, J., Seck, K., Heuschmann, P. U., Fiessler, C., Widmann, J., and Riederer, C.

Published
2022
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126. Administrative Prävalenz und Inzidenz der ADHS - Diagnosedefinition, Validierung und Versorgung

Author

Seck, K, Witte, J, Schlack, R, Neuperdt, L, Kuhnert, R, Hölling, H, Romanos, M, Jans, T, Berner, A, Hetzke, L, Weyrich, S, Emser, T, Hauer, D, Scholz, V, Ulsamer, S, Wallau, C, Ravens-Sieberer, U, Kaman, A, Gilbert, M, Greiner, W, Heuschmann, P, Fiessler, C, Widmann, J, Riederer, C, Horn, A, Seck, K, Witte, J, Schlack, R, Neuperdt, L, Kuhnert, R, Hölling, H, Romanos, M, Jans, T, Berner, A, Hetzke, L, Weyrich, S, Emser, T, Hauer, D, Scholz, V, Ulsamer, S, Wallau, C, Ravens-Sieberer, U, Kaman, A, Gilbert, M, Greiner, W, Heuschmann, P, Fiessler, C, Widmann, J, Riederer, C, and Horn, A

Published
2022

127. Therapeutic drug monitoring of sertraline in pediatric population: A naturalistic study with insights into the clinical response of obsessive-compulsive disorder

Author

Tini, E., additional, Smigielski, L., additional, Romanos, M., additional, Wewetzer, C., additional, Karwautz, A., additional, Reitzle, K., additional, Correll, C.U., additional, Plener, P.L., additional, Malzahn, U., additional, Heuschmann, P., additional, Unterecker, S., additional, Scherf-Clavel, M., additional, Rock, H., additional, Antony, G., additional, Briegel, W., additional, Fleischhaker, C., additional, Banaschewski, T., additional, Hellenschmidt, T., additional, Imgart, H., additional, Kaess, M., additional, Kölch, M., additional, Renner, T., additional, Reuter-Dang, S.Y., additional, Rexroth, C., additional, Schulte-Körne, G., additional, Theisen, F., additional, Fekete, S., additional, Taurines, R., additional, Gerlach, M., additional, Egberts, K.M., additional, and Walitza, S., additional

Published
2022
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128. Screening for dysglycaemia in patients with coronary artery disease as reflected by fasting glucose, oral glucose tolerance test, and HbA1c: a report from EUROASPIRE IV—a survey from the European Society of Cardiology

Author

Gyberg, Viveca, De Bacquer, Dirk, Kotseva, Kornelia, De Backer, Guy, Schnell, Oliver, Sundvall, Jouko, Tuomilehto, Jaakko, Wood, David, Rydén, Lars, Kotseva, K., De Backer, G., Amouyel, P., Bruthans, J., Castro Conde, A., Cifkova, R., De Bacquer, D., De Sutter, J., Deckers, J.W., Dilic, M., Dolzhenko, M., Erglis, A., Ferreira, T., Fraz, Z., Gaita, D., Gielen, S., Gotcheva, N., Goudevenos, I., Gyberg, V., Heuschmann, P., Laucevicius, A., Lehto, S., Lovic, D., Manini, M., Maggioni, A.P., Miličić, D., Moore, D., Nicolaides, E., Pajak, A., Pogosova, N., Reiner, Ž., Rydén, L., Schnell, O., Stagmo, M., Störk, S., Sundvall, J., Tokgözoğlu, L., Tuomilehto, J., Vulic, D., Wood, D., Wood, D.A., Kotseva, K., Jennings, C., Adamska, A., Rydén, L., Gyberg, V., Tuomilehto, J., Schnell, O., Manini, M., Ferreira, T., Taylor, C., Konte, M., Glemot, M., De Bacquer, D., De Backer, G., Sundvall, J., Lund, L., Leiviskä, J., De Bacquer, D., De Backer, G., De Pauw, M., Ghysbrecht, C., Vervaet, P., Maria Middelares, A.Z., De Sutter, J., Pardaens, S., Willems, A.M., Sint Lucas, A.Z., Cambier, P., Claeys, R., Deweerdt, N., Nimmegeers, J., Vandekerckhove, H., Verloove, H., Versee, L., Vulic, D., Djekic, D., Malesevic, G., Pejicic, S., Srdic, S., Dilic, M., Begic, A., Hodzic, E., Kulic, M., Sabanovic-Bajramovic, N., Tahirovic, E., Iveljic, I., Kovcic, J., Kusljugic, Z., Nurkic, M., Gotcheva, N., Baycheva, V., Georgiev, B., Vladimirov, G., Gotchev, D., Ivanov, S., Miličić, D., Samardžić, J., Perić, B., Sičaja, M., Nicolaides, E., Eftychiou, C., Eteocleous, N., Georgiou, P., Hadjilouca, C., Moutiris, J.A., Nicolaou, R., Papadopoulos, K., Patsalou, M., Bruthans, J., Cífková, R., Krajcoviechova, A., Wohlfahrt, P., Filipovský, J., Krizek, M., Kviderova, Z., Mayer, O., Vágovičová, P., Vanek, J., Seidlerova, J., Timoracká, K., Adamkova, V., Belohoubek, J., Galovcova, M., Zelenkova, V., Lehto, S., Kiljander, E., Kiljander, P., Kylmaoja, P., Lehto, H.R., Olkkonen, S., Pennanen, J., Herranen, M., Amouyel, P., Astolfi, A.L., Balik, S., Beauchant, S., Dallongeville, J., Devoghelaere, C., Fievet, N., Garboni, P., Lemaire, B., Marecaux, N., Montaye, M., Karmann, W., Held, S., Heuschmann, P., Eichstädt, K., Deckert, L., Fischer, D., Gerhardt, A., Kircher, J., Memmel, Y., Nolte, K., Schich, M., Wahl, V., Wagner, M., Störk, S., Ertl, G., Güntner, S., Leyh, R., Goudevenos, I., Kalantzi, K., Athanassias, D., Goumas, G., Krimbas, P., Richter, D., Sakellariou, D., Agrios, J., Matthaios, I., Papadopoulou, E., Toumanidis, S., Tsouna-Hatjis, E., Boufidou, A., Makedou, K., Lilis, L., Moore, D., Broderick, G., Fallon, N., Storey, S., Baronenko, I., Dormidontova, G., Dulkevica, A., Dzerve, V., Erglis, A., Andrejeva, T., Bricina, N., Jakovleva, J., Jaunromane, A., Keive, E., Klovane, M., Lurina, D., Makarova, L., Matisone, D., Mintale, I., Pahomova-Strautina, E., Putane, L., Stabulniece, M., Vasiljevs, D., Vevere, G., Vilks, J., Laucevicius, A., Alitoit, I., Badariene, J., Grabliauskaite, I., Jursyte, I., Paleviciute, E., Petrulioniene, Z., Serpytis, P., Serpytis, R., Solovjova, S., Smagriunaite, V., Babarskiene, R., Ceponiene, I., Gustiene, O., Karaliute, R., Rumbinaite, E., Slapikas, R., Smalinskas, V., Verseckaite, R., Pająk, A., Brzezicka, E., Łysek, R., Misiowiec, W., Wolfshaut-Wolak, R., Nessler, J., Podolec, P., Mirek-Bryniarska, E., Grodecki, J., Czarnecka, D., Łukaszewska, A., Jankowski, P., Bogacki, P., Gaita, D., Avram, C., Barzuca, E., Gaita, L., Jurca-Simina, F., Iancu, O.C., Lazar, A., Iurciuc, M., Iurciuc, S., Mal, M., Mancas, S., Mihaescu, A., Mociar, D., Mosteoru, S., Pescariu, S., Petrescu, L., Sasec, C., Schiller, A., Amarie, L., Andronic, A., Calin, S., Ciobanu, A., Cotoban, A., Guberna, S., Lungeanu, L., Mihalcea, D., Niculescu, N., Rimbas, R., Udroiu, C., Vinereanu, D., Pogosova, N., Ausheva, A., Boytsov, S., Kursakov, A., Oganov, R., Pozdnyakov, Y., Skazin, N., Lovic, D., Lovic, B., Nedeljkovic, M., Ostojic, M., Djordjevic, D., Kostic, S., Tasic, I., Zdravkovic, M., Anđić, M., Filipović, T., Ilić-Stojanović, O., Ješić-Jukić, M., Jevsnik, N., Lazović, M., Radović, A., Radović, D., Rosić, D., Spiroski, D., Stevović, S., Vidaković, T., Vuković-Dejanović, V., Fras, Z., Jug, B., Juhant, A., Poljancic, A., Poljancic, L., Castro Conde, A., Dalmau Gonzalez-Gallarza, R., Iniesta Manjavacas, A.M., Stagmo, M., Jernhed, H., Stensgaard, E., Gyberg, V., Boström, V., Edman Jönsson, C., Hage, C., Deckers, J.W., Khatibi, S., Yongzhao, F., Veerhoek, M., Smits, P.C., Minneboo, M., Peters, R.J.G., Scholte op Reimer, W., Snaterse-Zuidam, M., Tokgözoğlu, L., Asil, S., Kaya, B., Koçyiğit, D., Kozluca, V., Tulunay Kaya, C., Akyldz, İ., Ergene, O., Varş, E., Akdeniz, B., Göldeli, Ö., Kozan, Ö., Özpelit, E., Altay, S., Çam, N., Eren, M., Kaykçoğlu, M., Kültürsay, H., Aytekin, V., Burak Çatakoğlu, A., Abac, A., Candemir, M., Ünlü, S., Oğuz, A., Barçn, C., Yaşar, S., Yokuşoğlu, M., Aydoğdu, S., Temizhan, A., Ünal, S., Altuğ Çakmak, H., Çimci, M., Öngen, Z., Ateş, G., Koylan, N., Emet, S., Umman, B., Bostan, C., Sansoy, V., Kemal Erol, M., Kemal Kalkan, A., Kaymaz, C., Poçi, N., Dolzhenko, M., Getman, T., Konoplyanik, L., Klimenko, L., Lobach, L., Luchinskaya, Y., Lurie, L., Lutay, M., Mitchenko, E., Nemchena, O., Nosenko, N., Perepelchenko, N., Potashev, S., Radchenko, A., Romanov, V., Shumakov, V., Simagina, T., Sirenko, Y., Sychov, O., Mohnacheva, N., Verezhnikova, A., Zharinov, O., Lishnevskaya, V., Mikropulo, I., Prihodko, V., Shapovalenko, I., Wood, D., Adamska, A., Evans, J., Ioannides, K., Jennings, C., Kasonta, A., Kotseva, K., Onyango, H., Rapacz, A., Wrotniak, B., Dubrey, S., Barbir, M., Connolly, S., Dancy, M., Collins, P., and Kaprielian, R.

Published
2015
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129. Erwartungen, Wünsche und Vorbehalte bei der Implementierung von unterschiedlichen Surveillance-Protokollen zur Detektion von SARS-CoV-2-Infektionen in Kinderbetreuungseinrichtungen – Wü-KiTa-CoV-Studie

Author

Gierszewski, D, Krauthausen, M, Forster, J, Streng, A, Pietsch, F, Wallstabe, J, Hartmann, K, Rücker, V, Schmidt, J, Ludwig, T, Heuschmann, P, Jans, T, Weißbrich, B, Romanos, M, Dölken, L, Härtel, C, Kurzai, O, Liese, J, and Gágyor, I

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund: Im Rahmen der „Würzburger Kinderbetreuungsstudie in der Covid-19-Pandemie“ wurde die Machbarkeit und Akzeptanz unterschiedlicher Surveillance-Protokolle (Nasenabstriche 1x oder 2x wöchentlich bzw. Speichelproben 2x wöchentlich bei asymptomatischen und Rachenabstrich [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2021
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130. Die beeinträchtigte psychische Gesundheit von medizinischem Personal in einer deutschen anästhesiologischen Klinik ist unabhängig von unmittelbarer SARS-CoV-2-Exposition - eine Längsschnitt-Beobachtungsstudie

Author

Schmid, B, Schulz, SM, Schuler, M, Göpfert, D, Hein, G, Heuschmann, P, Wurmb, T, Pauli, P, Meybohm, P, and Rittner, HL

Subjects
critical care, medizinisches Personal, ddc: 610, healthcare workers, Intensivmedizin, psychische Gesundheit, COVID-19, anesthesia, mental health, Anästhesie
Abstract

Background: The study aimed to assess the mental well-being of healthcare professionals at a German department of anesthesiology and critical care with a specialized ICU for treatment of COVID-19 patients during the first two peaks of the 2020 pandemic, and identifying risk and protective factors.Methods: A single-center longitudinal, online-based survey was conducted in healthcare workers from a department of anesthesiology and critical care in Bavaria, the most affected federal state in Germany at the time of assessment. Validated scores for depression, anxiety, somatic disorders, burnout, resilience, and self-management were used and complemented by questions about perceived COVID-19-related stressors. In parallel, patient characteristics in the ICU were collected.Results: 24 and 23 critically ill COVID-19 patients were treated during both observation periods in April/May and November/December 2020, respectively. 87.5% and 78.2% of patients had moderate to severe acute respiratory distress syndrome. From March 6, 2020 onwards, the hospital had switched to a command and control-based hospital incident command system (HICS) and increased work forces. Point prevalence of depression-like symptoms (13.6% and 12.8%) and burnout (21.6% and 17.4%) in the department's healthcare professionals was high. Exposure to SARS-CoV-2 did not increase psychological burden. Consequences of the lockdown were rated as highly distressing by a majority of all ICU personnel. High self-reported trait resilience was protective against signs of depression, generalized anxiety, and burnout.Conclusions: During the pandemic, healthcare professionals have been suffering from increased psychological distress compared to reference data for both the general population and ICU personnel. General effects of the lockdown appear more relevant than actual COVID-19 patient contact. High trait resilience has a protective effect, yet vulnerable individuals may require specific support. Prevention against potential after effects of the lockdown, and in particular measures allowing to avoid another lockdown, appear warranted. Hintergrund: Die Studie hatte zum Ziel, die psychische Gesundheit der anästhesiologischen Mitarbeiterinnen und Mitarbeiter einer Universitätsklinik mit einer auf COVID-19 spezialisierten Intensivstation während der ersten beiden Wellen der Pandemie im Frühjahr und Herbst 2020 zu untersuchen und sowohl Risikofaktoren als auch protektive Faktoren zu identifizieren.Methoden: Es wurde eine monozentrische, Web-basierte Umfrage unter medizinischen Angestellten der Klinik für Anästhesiologie, Universitätsklinikum Würzburg, durchgeführt. Hierzu wurden validierte Tests zu den Domänen Depressivität, Ängstlichkeit, somatoforme Störungen, Burnout, Resilienz und Selbstmanagement verwendet und des Weiteren offene Fragen zu subjektiv belastenden, COVID-19-assoziierten Faktoren gestellt. Zusätzlich wurden Charakteristika der in den Umfragezeiträumen behandelten Patientinnen und Patienten sowie Informationen zum Krankenhausmanagement während der Pandemie erfasst.Ergebnisse: In den beiden Erhebungszeiträumen wurden 24 bzw. 23 kritisch kranke COVID-19-Patientinnen und -Patienten behandelt. 87.5% bzw. 78.2% der Patientinnen und Patienten litten an einer moderaten bis schweren Form des adulten akuten Lungenversagens. Ab dem 6. März 2020 implementierte die Klinik eine streng hierarchische Notfall-Einsatzleitung, um tagesaktuell auf die Dynamik der Pandemie reagieren zu können, und die personellen Ressourcen wurden erhöht. Punktprävalenzen von Depressivität (13,6% und 12.8%) und Burnout (21,3% und 17.4%) bei den Studienteilnehmerinnen und -teilnehmern waren hoch. Die unmittelbare psychische Belastung war unabhängig von einer Exposition gegenüber SARS-CoV-2. Die Auswirkungen der Ausgangsbeschränkungen wurden von einer Mehrheit der Untersuchten als stark beeinträchtigend beschrieben. Hohe Resilienz schien protektiv zu wirken gegen Anzeichen von Depressivität, generalisierter Angst und Burnout.Schlussfolgerungen: Im Verlauf der ersten Monate der Pandemie litt das medizinische Personal unter erhöhter psychischer Belastung verglichen mit früheren Vergleichsdaten sowohl der Allgemeinbevölkerung als auch von Personal auf Intensivstationen. Die allgemeinen Auswirkungen der Ausgangsbeschränkungen schienen hierbei einen größeren Einfluss gehabt zu haben als der tatsächliche Kontakt mit COVID-19-Patientinnen und -Patienten. Ausgeprägte Resilienz hatte einen positiven Effekt. Allerdings könnten anfällige Mitarbeiterinnen und Mitarbeiter unter Umständen gezielte Unterstützung benötigen. Zudem sind vorbeugende Maßnahmen gegen mögliche Nachwirkungen der Pandemie-Beschränkungen sowie alle Maßnahmen, die geeignet erscheinen, einen weiteren Lockdown zu verhindern, sinnvoll.

Published
2021

133. Impact of excessive supraventricular ectopic activity detected in the acute phase of stroke or TIA on AF detection and death within 24 months – results of the prospective MonDAFIS study

Author

Haeusler, K G H, primary, Olma, M C O, additional, Tuetuencue, S T, additional, Fiessler, C F, additional, Kunze, C K, additional, Jawad-Ul-Qamar, M J Q, additional, Kraemer, M K, additional, Laufs, U L, additional, Heuschmann, P U H, additional, Kirchhof, P K, additional, and Endres, M E, additional

Published
2021
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138. Veränderung der psychischen Belastung von Eltern und Betreuer*innen in Kindertagesstätten während verschiedener Surveillance-Protokolle zur Detektion von SARS-CoV-2-Infektionen in der Würzburger Kinderbetreuungsstudie (Wü-KiTa-CoV)

Author

Krauthausen, M, Gierszewski, D, Forster, J, Streng, A, Pietsch, F, Wallstabe, J, Hartmann, K, Rücker, V, Schmidt, J, Ludwig, T, Heuschmann, P, Jans, T, Weissbrich, B, Romanos, M, Dölken, L, Härtel, C, Kurzai, O, Liese, J, Gágyor, I, Krauthausen, M, Gierszewski, D, Forster, J, Streng, A, Pietsch, F, Wallstabe, J, Hartmann, K, Rücker, V, Schmidt, J, Ludwig, T, Heuschmann, P, Jans, T, Weissbrich, B, Romanos, M, Dölken, L, Härtel, C, Kurzai, O, Liese, J, and Gágyor, I

Published
2021

140. Impaired psychological well-being of healthcare workers in a German department of anesthesiology is independent of immediate SARS-CoV-2 exposure - a longitudinal observational study

Author

Schmid, B, Schulz, SM, Schuler, M, Göpfert, D, Hein, G, Heuschmann, P, Wurmb, T, Pauli, P, Meybohm, P, Rittner, HL, Schmid, B, Schulz, SM, Schuler, M, Göpfert, D, Hein, G, Heuschmann, P, Wurmb, T, Pauli, P, Meybohm, P, and Rittner, HL

Abstract

Background: The study aimed to assess the mental well-being of healthcare professionals at a German department of anesthesiology and critical care with a specialized ICU for treatment of COVID-19 patients during the first two peaks of the 2020 pandemic, and identifying risk and protective factors.Methods: A single-center longitudinal, online-based survey was conducted in healthcare workers from a department of anesthesiology and critical care in Bavaria, the most affected federal state in Germany at the time of assessment. Validated scores for depression, anxiety, somatic disorders, burnout, resilience, and self-management were used and complemented by questions about perceived COVID-19-related stressors. In parallel, patient characteristics in the ICU were collected.Results: 24 and 23 critically ill COVID-19 patients were treated during both observation periods in April/May and November/December 2020, respectively. 87.5% and 78.2% of patients had moderate to severe acute respiratory distress syndrome. From March 6, 2020 onwards, the hospital had switched to a command and control-based hospital incident command system (HICS) and increased work forces. Point prevalence of depression-like symptoms (13.6% and 12.8%) and burnout (21.6% and 17.4%) in the department's healthcare professionals was high. Exposure to SARS-CoV-2 did not increase psychological burden. Consequences of the lockdown were rated as highly distressing by a majority of all ICU personnel. High self-reported trait resilience was protective against signs of depression, generalized anxiety, and burnout.Conclusions: During the pandemic, healthcare professionals have been suffering from increased psychological distress compared to reference data for both the general population and ICU personnel. General effects of the lockdown appear more relevant than actual COVID-19 patient contact. High trait resilience has a protective effect, yet vulnerable individuals may require specific support. Prevention against, Hintergrund: Die Studie hatte zum Ziel, die psychische Gesundheit der anästhesiologischen Mitarbeiterinnen und Mitarbeiter einer Universitätsklinik mit einer auf COVID-19 spezialisierten Intensivstation während der ersten beiden Wellen der Pandemie im Frühjahr und Herbst 2020 zu untersuchen und sowohl Risikofaktoren als auch protektive Faktoren zu identifizieren.Methoden: Es wurde eine monozentrische, Web-basierte Umfrage unter medizinischen Angestellten der Klinik für Anästhesiologie, Universitätsklinikum Würzburg, durchgeführt. Hierzu wurden validierte Tests zu den Domänen Depressivität, Ängstlichkeit, somatoforme Störungen, Burnout, Resilienz und Selbstmanagement verwendet und des Weiteren offene Fragen zu subjektiv belastenden, COVID-19-assoziierten Faktoren gestellt. Zusätzlich wurden Charakteristika der in den Umfragezeiträumen behandelten Patientinnen und Patienten sowie Informationen zum Krankenhausmanagement während der Pandemie erfasst.Ergebnisse: In den beiden Erhebungszeiträumen wurden 24 bzw. 23 kritisch kranke COVID-19-Patientinnen und -Patienten behandelt. 87.5% bzw. 78.2% der Patientinnen und Patienten litten an einer moderaten bis schweren Form des adulten akuten Lungenversagens. Ab dem 6. März 2020 implementierte die Klinik eine streng hierarchische Notfall-Einsatzleitung, um tagesaktuell auf die Dynamik der Pandemie reagieren zu können, und die personellen Ressourcen wurden erhöht. Punktprävalenzen von Depressivität (13,6% und 12.8%) und Burnout (21,3% und 17.4%) bei den Studienteilnehmerinnen und -teilnehmern waren hoch. Die unmittelbare psychische Belastung war unabhängig von einer Exposition gegenüber SARS-CoV-2. Die Auswirkungen der Ausgangsbeschränkungen wurden von einer Mehrheit der Untersuchten als stark beeinträchtigend beschrieben. Hohe Resilienz schien protektiv zu wirken gegen Anzeichen von Depressivität, generalisierter Angst und Burnout.Schlussfolgerungen: Im Verlauf der ersten Monate der Pandemie litt das medizinische Personal unter

Published
2021

147. Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke

Author

Arends, Christopher M., Liman, Thomas G., Strzelecka, Paulina M., Kufner, Anna, Löwe, Pelle, Huo, Shufan, Stein, Catarina M., Piper, Sophie K., Tilgner, Marlon, Sperber, Pia S., Dimitriou, Savvina, Heuschmann, Peter U., Hablesreiter, Raphael, Harms, Christoph, Bullinger, Lars, Weber, Joachim E., Endres, Matthias, and Damm, Frederik

Abstract

Clonal hematopoiesis (CH) is common among older people and is associated with an increased risk of atherosclerosis, inflammation, and shorter overall survival. Age and inflammation are major risk factors for ischemic stroke, yet the association of CH with risk of secondary vascular events and death is unknown. We investigated CH in peripheral blood DNA from 581 patients with first-ever ischemic stroke from the Prospective Cohort With Incident Stroke–Berlin study using error-corrected targeted sequencing. The primary composite end point (CEP) consisted of recurrent stroke, myocardial infarction, and all-cause mortality. A total of 348 somatic mutations with a variant allele frequency ≥1% were identified in 236 of 581 patients (41%). CH was associated with large-artery atherosclerosis stroke (P = .01) and white matter lesion (P < .001). CH-positive patients showed increased levels of proinflammatory cytokines, such as interleukin-6 (IL-6), interferon gamma, high-sensitivity C-reactive protein, and vascular cell adhesion molecule 1. CH-positive patients had a higher risk for the primary CEP (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.04-2.31; P = .03), which was more pronounced in patients with larger clones. CH clone size remained an independent risk factor (HR, 1.30; 95% CI, 1.04-1.62; P = .022) in multivariable Cox regression. Although our data show that, in particular, larger and TET2- or PPM1D-mutated clones are associated with increased risk of recurrent vascular events and death, this risk is partially mitigated by a common germline variant of the IL-6 receptor (IL-6R p.D358A). The CH mutation profile is accompanied by a proinflammatory profile, opening new avenues for preventive precision medicine approaches to resolve the self-perpetuating cycle of inflammation and clonal expansion.

Published
2023
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148. Self-Assessment of Having COVID-19 With the Corona Check mHealth App

Author

Beierle, Felix, Allgaier, Johannes, Stupp, Carolin, Keil, Thomas, Schlee, Winfried, Schobel, Johannes, Vogel, Carsten, Haug, Fabian, Haug, Julian, Holfelder, Marc, Langguth, Berthold, Langguth, Jana, Riens, Burgi, King, Ryan, Mulansky, Lena, Schickler, Marc, Stach, Michael, Heuschmann, Peter, Wildner, Manfred, Greger, Helmut, Reichert, Manfred, Kestler, Hans A., and Pryss, Rudiger

Abstract

At the beginning of the COVID-19 pandemic, with a lack of knowledge about the novel virus and a lack of widely available tests, getting first feedback about being infected was not easy. To support all citizens in this respect, we developed the mobile health app Corona Check. Based on a self-reported questionnaire about symptoms and contact history, users get first feedback about a possible corona infection and advice on what to do. We developed Corona Check based on our existing software framework and released the app on Google Play and the Apple App Store on April 4, 2020. Until October 30, 2021, we collected 51,323 assessments from 35,118 users with explicit agreement of the users that their anonymized data may be used for research purposes. For 70.6% of the assessments, the users additionally shared their coarse geolocation with us. To the best of our knowledge, we are the first to report about such a large-scale study in this context of COVID-19 mHealth systems. Although users from some countries reported more symptoms on average than users from other countries, we did not find any statistically significant differences between symptom distributions (regarding country, age, and sex). Overall, the Corona Check app provided easily accessible information on corona symptoms and showed the potential to help overburdened corona telephone hotlines, especially during the beginning of the pandemic. Corona Check thus was able to support fighting the spread of the novel coronavirus. mHealth apps further prove to be valuable tools for longitudinal health data collection.

Published
2023
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149. Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries

Author

De Backer, Guy Jankowski, Piotr Kotseva, Kornelia and Mirrakhimov, Erkin Reiner, Zeljko Ryden, Lars Tokgozoglu, Lale Wood, David De Bacquer, Dirk Abreu, A. Aguiar, C. and Badariene, J. Bruthans, J. Castro Conde, A. Cifkova, R. and Crowley, J. Davletov, K. De Smedt, D. De Sutter, J. and Deckers, J. W. Dilic, M. Dolzhenko, M. Druais, H. and Dzerve, V. Erglis, A. Fras, Z. Gaita, D. Gotcheva, N. and Grobbee, D. E. Gyberg, V. Ali, H. Hasan Heuschmann, P. and Hoes, A. W. Lalic, N. Lehto, S. Lovic, D. Maggioni, A. P. Mancas, S. Marques-Vidal, P. Mellbin, L. Milicic, D. Oganov, R. Pogosova, N. Stagmo, M. Stoerk, S. and Sundvall, J. Tsioufis, K. Vulic, D. Wood, D. A. and Jennings, C. Adamska, A. Adamska, S. Mellbin, L. and Tuomilehto, J. Schnell, O. Fiorucci, E. Glemot, M. and Larras, F. Missiamenou, V. Maggioni, A. Taylor, C. and Ferreira, T. Lemaitre, K. Raman, L. Sundvall, J. and DeSmedt, D. De Sutter, J. Willems, A. M. De Pauw, M. and Vervaet, P. Bollen, J. Dekimpe, E. Mommen, N. Van Genechten, G. Dendale, P. Bouvier, C. A. Chenu, P. and Huyberechts, D. Persu, A. Dilic, M. Begic, A. Nalbantic, A. Durak Dzubur, A. Hadzibegic, N. Iglica, A. Kapidjic, S. Bico, A. Osmanagic Resic, N. Bajramovic, N. Sabanovic and Zvizdic, F. Vulic, D. Kovacevic-Preradovic, T. and Popovic-Pejicic, S. Djekic, D. Gnjatic, T. Knezevic, T. and Kovacevic-Preradovic, T. Kos, Lj Popovic-Pejicic, S. and Stanetic, B. Topic, G. Gotcheva, N. Georgiev, Borislav and Terziev, A. Vladimirov, G. Angelov, A. Kanazirev, B. and Nikolaeva, S. Tonkova, D. Vetkova, M. Milicic, D. and Bosnic, A. Dubravcic, M. Glavina, M. Mance, M. and Pavasovic, S. Samardzic, J. Batinic, T. Crljenko, K. and Delic-Brkljacic, D. Dula, K. Golubic, K. Klobucar, I. and Kordic, K. Kos, N. Nedic, M. Olujic, D. Sedinic, V. and Blazevic, T. Pasalic, A. Percic, M. Sikic, J. Bruthans, J. Cifkova, R. Hasplova, K. Sulc, P. Wohlfahrt, P. and Mayer, Jr., O. Cvicela, M. Filipovsky, J. Gelzinsky, J. and Hronova, M. Hasan-Ali, H. Bakery, S. Mosad, E. Hamed, H. B. Ibrahim, A. Elsharef, M. A. Kholef, E. F. Shehata, A. and Youssef, M. Elhefny, E. Farid, H. Moustafa, T. M. and Sobieh, M. S. Kabil, H. Abdelmordy, A. Lehto, S. and Kiljander, E. Kiljander, P. Koukkunen, H. Mustonen, J. and Cremer, C. Frantz, S. Haupt, A. Hofmann, U. Ludwig, K. and Melnyk, H. Noutsias, M. Karmann, W. Prondzinsky, R. and Herdeg, C. Hoevelborn, T. Daaboul, A. Geisler, T. and Keller, T. Sauerbrunn, D. Walz-Ayed, M. Ertl, G. Leyh, R. Stoerk, S. Heuschmann, P. Ehlert, T. Klocke, B. and Krapp, J. Ludwig, T. Kaes, J. Starke, C. Ungethuem, K. and Wagner, M. Wiedmann, S. Tsioufis, K. Tolis, P. and Vogiatzi, G. Sanidas, E. Tsakalis, K. Kanakakis, J. and Koutsoukis, A. Vasileiadis, K. Zarifis, J. Karvounis, C. and Crowley, J. Gibson, I. Houlihan, A. Kelly, C. O'Donnell, M. Bennati, M. Cosmi, F. Mariottoni, B. Morganti, M. and Cherubini, A. Di Lenarda, A. Radini, D. Ramani, F. and Francese, M. G. Gulizia, M. M. Pericone, D. Davletov, K. and Aigerim, K. Bekbolat, Z. Amirov, B. Assembekov, B. and Chernokurova, E. Ibragimova, F. Kodasbayev, A. Markova, A. and Asanbaev, A. Toktomamatov, U. Tursunbaev, M. Zakirov, U. and Abilova, S. Arapova, R. Bektasheva, E. Esenbekova, J. and Neronova, K. Asanbaev, A. Baigaziev, K. Toktomamatov, U. and Zakirov, U. Baitova, G. Zheenbekov, T. Erglis, A. and Andrejeva, T. Bajare, I. Kucika, G. Labuce, A. Putane, L. Stabulniece, M. Dzerve, V. Klavins, E. Sime, I. and Badariene, J. Gedvilaite, L. Peciuraite, D. Sileikiene, V. and Skiauteryte, E. Solovjova, S. Sidabraite, R. Briedis, K. and Ceponiene, I. Jurenas, M. Kersulis, J. Martinkute, G. and Vaitiekiene, A. Vasiljevaite, K. Veisaite, R. Plisiene, J. Siurkaite, V. Vaiciulis, Z. Czarnecka, D. Koziel, P. and Podolec, P. Nessler, J. Gomula, P. Mirek-Bryniarska, E. and Bogacki, P. Wisniewski, A. Pajak, A. Wolfshaut-Wolak, R. and Bucko, J. Kaminski, K. Lapinska, M. Paniczko, M. and Raczkowski, A. Sawicka, E. Stachurska, Z. Szpakowicz, M. and Musial, W. Dobrzycki, S. Bychowski, J. Kosior, D. A. and Krzykwa, A. Setny, M. Kosior, D. A. Rak, A. Gasior, Z. and Haberka, M. Gasior, Z. Haberka, M. Szostak-Janiak, K. and Finik, M. Liszka, J. Botelho, A. Cachulo, M. Sousa, J. Pais, A. Aguiar, C. Durazzo, A. Matos, D. and Gouveia, R. Rodrigues, G. Strong, C. Guerreiro, R. and Aguiar, J. Abreu, A. Cruz, M. Daniel, P. Morais, L. and Moreira, R. Rosa, S. Rodrigues, I. Selas, M. Gaita, D. and Mancas, S. Apostu, A. Cosor, O. Gaita, L. Giurgiu, L. Hudrea, C. Maximov, D. Moldovan, B. Mosteoru, S. and Pleava, R. Ionescu, M. Parepa, I. Pogosova, N. and Arutyunov, A. Ausheva, A. Isakova, S. Karpova, A. and Salbieva, A. Sokolova, O. Vasilevsky, A. Pozdnyakov, Y. and Antropova, O. Borisova, L. Osipova, I. Lovic, D. and Aleksic, M. Crnokrak, B. Djokic, J. Hinic, S. Vukasin, T. Zdravkovic, M. Lalic, N. M. Jotic, A. Lalic, K. and Lukic, L. Milicic, T. Macesic, M. Gajovic, J. Stanarcic and Stoiljkovic, M. Djordjevic, D. Kostic, S. Tasic, I. and Vukovic, A. Fras, Z. Jug, B. Juhant, A. Krt, A. and Kugonjic, U. Chipayo Gonzales, D. Gomez Barrado, J. J. and Kounka, Z. Marcos Gomez, G. Mogollon Jimenez, M. V. Ortiz Cortes, C. Perez Espejo, P. Porras Ramos, Y. Colman, R. and Delgado, J. Otero, E. Perez, A. Fernandez-Olmo, M. R. and Torres-LLergo, J. Vasco, C. Barrenada, E. Botas, J. and Campuzano, R. Gonzalez, Y. Rodrigo, M. de Pablo, C. and Velasco, E. Hernandez, S. Lozano, C. Gonzalez, P. and Castro, A. Dalmau, R. Hernandez, D. Irazusta, F. J. and Velez, A. Vindel, C. Gomez-Doblas, J. J. Garcia Ruiz, V. and Gomez, L. Gomez Garcia, M. Jimenez-Navarro, M. Molina Ramos, A. Marzal, D. Martinez, G. Lavado, R. Vidal, A. and Bostrom-Nilsson, V. Kjellstrom, B. Shahim, B. Smetana, S. and Hansen, O. Stensgaard-Nake, E. Deckers, J. W. Klijn, A. J. Mangus, T. J. P. Peters, R. J. G. Reimer, W. Scholte Op and Snaterse, M. Aydogdu, S. Erol, C. Oturk, S. Kaya, C. Tulunay Ahmetoglu, Y. Ergene, O. Akdeniz, B. Cirgamis, D. Kultursay, S. Akkoyun H. Kayikcioglu, M. Catakoglu, A. B. and Cengel, A. Kocak, A. A. Agirbasli, M. A. Aciksari, G. and Cekin, M. E. Kaya, E. B. Kocyigit, D. Ongen, Z. and Ozmen, E. Sansoy, V. Kaya, A. Oktay, V. Temizhan, A. and Unal, S. Yakut, I. Kalkan, A. K. Bozkurt, E. Kasapkara, H. A. Dolzhenko, M. Faradzh, C. Hrubyak, L. Konoplianyk, L. Kozhuharyova, N. Lobach, L. Nesukai, V. Nudchenko, O. and Simagina, T. Yakovenko, L. Azarenko, V. Potabashny, V. and Bazylevych, A. Bazylevych, M. Kaminska, K. Panchenko, L. and Shershnyova, O. Ovrakh, T. Serik, S. Kolesnik, T. and Kosova, H. Adamska, A. Adamska, S. Jennings, C. Atkin, A. Hoye P. Fellowes, D. Lindsay, S. Atkinson, C. and Kranilla, C. Vinod, M. Beerachee, Y. Bennett, C. Broome, M. Bwalya, A. Caygill, Lindsay Dinning, L. Gillespie, A. and Goodfellow, R. Guy, J. Idress, T. Mills, C. Morgan, C. Oustance, N. Singh, N. Yare, M. Jagoda, J. M. and Bowyer, H. Christenssen, V. Groves, A. Jan, A. Riaz, A. and Gill, M. Sewell, T. A. Gorog, D. Baker, M. De Sousa, P. Mazenenga, T. Porter, J. Haines, F. Peachey, T. and Taaffe, J. Wells, K. Ripley, D. P. Forward, H. McKie, H. and Pick, S. L. Thomas, H. E. Batin, P. D. Exley, D. and Rank, T. Wright, J. Kardos, A. Sutherland, S. -B. Wren, L. Leeson, P. Barker, D. Moreby, B. Sawyer, J. and Stirrup, J. Brunton, M. Brodison, A. Craig, J. Peters, S. Kaprielian, R. Bucaj, A. Mahay, K. Oblak, M. and Gale, C. Pye, M. McGill, Y. Redfearn, H. Fearnley, M. and EUROASPIRE V Collaborators Writing Comm Sci Steering Executive Comm Coordinating Ctr Diabet Ctr Data Management Ctr Stat Anal Ctr Cent Lab Study Ctr Org Investigators Other

Abstract

Background and aims: One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients. Methods: Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medical records and at a visit at least 6 months after hospitalization for a coronary event. All lipid measurements were performed in one central laboratory. Patients were divided into three groups: on high-intensity LDL-C-lowering-drug therapy (LLT), on low or moderate-intensity LLT and on no LLT. Results: At the time of the visit, almost half of the patients were on a high-intensity LLT. Between hospital discharge and the visit, LLT had been reduced in intensity or interrupted in 20.8% of the patients and had been started or increased in intensity in 11.7%. In those who had interrupted LLT or had reduced the intensity, intolerance to LLT and the advice of their physician were reported as the reason why in 15.8 and 36.8% of the cases, respectively. LDL-C control was better in those on a high-intensity LLT compared to those on low or moderate intensity LLT. LDL-C control was better in men than women and in patients with self-reported diabetes. Conclusions: The results of the EUROASPIRE V survey show that most coronary patients have a less than optimal management of LDL-C. More professional strategies are needed, aiming at lifestyle changes and LLT adapted to the need of the individual patient.

Published
2019

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