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2,066 results on '"Grossman, H."'

101. Incidence of downstaging and complete remission after neoadjuvant chemotherapy for high-risk upper tract transitional cell carcinoma

Author

Matin, Surena F., Margulis, Vitaly, Kamat, Ashish, Wood, Christopher G., Grossman, H. Barton, Brown, Gordon A., Dinney, Colin P.N., Millikan, Randall, and Siefker-Radtke, Arlene O.

Subjects
Adenocarcinoma -- Care and treatment, Adenocarcinoma -- Patient outcomes, Adenocarcinoma -- Research, Neoadjuvant therapy -- Patient outcomes, Neoadjuvant therapy -- Research, Cancer regression -- Research, Carcinoma, Renal cell -- Care and treatment, Carcinoma, Renal cell -- Patient outcomes, Carcinoma, Renal cell -- Research, Health
Published
2010

112. Quality of pathologic response and surgery correlate with survival for patients with completely resected bladder cancer after neoadjuvant chemotherapy

Author

Sonpavde, Guru, Goldman, Bryan H., Speights, V.O., Lerner, Seth P., Wood, David P., Vogelzang, Nicholas J., Trump, Donald L., Natale, Ronald B., Grossman, H. Barton, and Crawford, E. David

Subjects
Bladder cancer -- Care and treatment, Bladder cancer -- Patient outcomes, Bladder cancer -- Research, Neoadjuvant therapy -- Patient outcomes, Neoadjuvant therapy -- Research, Outcome and process assessment (Health Care) -- Research, Health
Published
2009

117. Is Exam under Anesthesia Still Necessary for the Staging of Bladder Cancer in the Era of Modern Imaging?

Author

Rozanski, Alexander T., Benson, Cooper R., McCoy, Jacob A., Green, Charles, Grossman, H. Barton, Svatek, Robert S., and Shah, Jay B.

Abstract

The ability to accurately determine tumor stage in bladder cancer is critical because it impacts the management paradigm and overall prognosis. There is often discrepancy between clinical and pathologic staging. Historically, exam under anesthesia (EUA) has been recommended to assist in the staging of bladder cancer. In this era of modern imaging technology, we sought to determine if EUA still contributes meaningfully to the local staging of bladder cancer. We retrospectively reviewed the charts of 1898 patients from 1994–2013 in our radical cystectomy database at MD Anderson Cancer Center. There were 414 patients that had complete information including EUA and whose surgery was performed by one of two surgeons and included in the final analysis. Univariate and multiple logistic regression models were generated to determine the ability of EUA, imaging, and other patient characteristics to predict pathological fat extension at the time of cystectomy. 38% of patients had≥pT3 disease at the time of cystectomy. 30.9% of patients had findings on EUA suggestive of T3 disease and 28.7% had radiologic findings suggestive of T3 disease. In a model including age, BMI, ethnicity, year of operation, and neoadjuvant chemotherapy among other factors, the only factors predictive of pT3 disease were EUA and imaging (p = 0.002). The combination of EUA and imaging improved the accuracy of clinical staging compared to either modality alone. Despite modern advances in imaging, EUA contributes meaningfully to accurate determination of local bladder cancer stage.

Published
2022
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118. A blood-based signature of cerebrospinal fluid A beta(1-42) status

Author

Goudey, B., Fung, B.J., Schieber, C., Faux, N.G., Weiner, M.W., Aisen, P., Petersen, R., Jack, C.R., Jagust, W., Trojanowki, J.Q., Toga, A.W., Beckett, L., Green, R.C., Saykin, A.J., Morris, J., Shaw, L.M., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R., Dolen, S., Schneider, L.S., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B.M., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J.L., Lord, J.L., Mason, S.S., Albers, C.S., Knopman, D., Johnson, K., Doody, R.S., Villanueva-Meyer, J., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L.S., Bell, K.L., Ances, B., Morris, J.C., Carroll, M., Creech, M.L., Franklin, E., Mintun, M.A., Schneider, S., Oliver, A., Marson, D., Griffth, R., Clark, D., Geldmacher, D., Brockington, J., Roberson, E., Natelson Love, M., Grossman, H., Mitsis, E., Shah, R.C., deToledo-Morrell, L., Duara, R., Varon, D., Greig, M.T., Roberts, P., Albert, M., Onyike, C., D'Agostino, D., Kielb, S., Galvin, J.E., Cerbone, B., Michel, C.A., Pogorelec, D.M., Rusinek, H., Leon, M.J. de, Glodzik, L., De Santi, S., Doraiswamy, P.M., Petrella, J.R., Borges-Neto, S., Wong, T.Z., Coleman, E., Smith, C.D., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Porsteinsson, A.P., Goldstein, B.S., Martin, K., Makino, K.M., Ismail, M.S., Brand, C., Mulnard, R.A., Thai, G., McAdams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Levey, A.I., Lah, J.J., Cellar, J.S., Burns, J.M., Swerdlow, R.H., Brooks, W.M., Apostolova, L., Tingus, K., Woo, E., Silverman, D.H.S., Lu, P.H., Bartzokis, G., Graff-Radford, N.R., Parftt, F., Kendall, T., Johnson, H., Farlow, M.R., Hake, A.M., Matthews, B.R., Brosch, J.R., Herring, S., Hunt, C., Dyck, .H. van, Carson, R.E., MacAvoy, M.G., Varma, P., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Hsiung, Ging-Yuek Robin, Feldman, H., Mudge, B., Assaly, M., Finger, E., Pasternack, S., Rachisky, I., Trost, D., Kertesz, A., Bernick, C., Munic, D., Mesulam, M.-M., Lipowski, K., Weintraub, S., Bonakdarpour, B., Kerwin, D., Wu, C.-K., Johnson, N., Sadowsky, C., Villena, T., Turner, R.S., Reynolds, B., Sperling, R.A., Johnson, K.A., Marshall, G., Yesavage, J., Taylor, J.L., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M.N., Belden, C.M., Jacobson, S.A., Sirrel, S.A., Kowall, N., Killiany, R., Budson, A.E., Norbash, A., Johnson, P.L., Obisesan, T.O., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Fletcher, E., Maillard, P., Olichney, J., DeCarli, C., Carmichael, O., Kittur, S., Borrie, M., Lee, T.-Y., Bartha, R., Johnson, S., Asthana, S., Carlsson, C.M., Potkin, S.G., Preda, A., Nguyen, D., Tariot, P., Burke, A., Trncic, N., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D.W., Kataki, M., Adeli, A., Zimmerman, E.A., Celmins, D., Brown, A.D., Pearlson, G.D., Blank, K., Anderson, K., Flashman, L.A., Seltzer, M., Hynes, M.L., Santulli, R.B., Sink, K.M., Gordineer, L., Williamson, J.D., Garg, P., Watkins, F., Ott, B.R., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H.J., Miller, B.L., Perry, D., Mintzer, J., Spicer, K., Bachman, D., Pomara, N., Hernando, R., Sarrael, A., Relkin, N., Chaing, G., Lin, M., Ravdin, L., Smith, A., Raj, B.A., Fargher, K., Saykin, A., Nho, K., Kling, M., Toledo, J., Shaw, L., Trojanowski, J., Farrer, L., Kastsenmueller, G., Arnold, M., Wishart, D., Wurtz, P., Bhattcharyya, S., Duijin, C. van, Mangravite, L., Han, X., Hankemeier, T., Fiehn, O., Barupal, D., Thiele, I., Heinken, A., Meikle, P., Price, N., Funk, C., Jia, W., Kueider-Paisley, A., Tenebaum, J., Black, C., Moseley, A., Thompson, W., Mahmoudiandehkorki, S., Baillie, R., Welsh-Bohmer, K., Plassman, B., and Epidemiology

Subjects
Male, 0301 basic medicine, Apolipoprotein E, Oncology, medicine.medical_specialty, Amyloid, Amyloid beta, lcsh:Medicine, Article, 03 medical and health sciences, Apolipoproteins E, 0302 clinical medicine, Cerebrospinal fluid, Alzheimer Disease, Predictive Value of Tests, Internal medicine, medicine, Humans, Dementia, Cognitive decline, lcsh:Science, Aged, Aged, 80 and over, Amyloid beta-Peptides, Multidisciplinary, biology, Chemokine CCL26, business.industry, lcsh:R, Alzheimer’s Disease Metabolomics Consortium, Alzheimer’s Disease Neuroimaging Initiative, medicine.disease, Peptide Fragments, 3. Good health, 030104 developmental biology, biology.protein, Chromogranin A, Female, lcsh:Q, Alzheimer's disease, business, Biomarkers, 030217 neurology & neurosurgery, Alzheimer's Disease Neuroimaging Initiative
Abstract

It is increasingly recognized that Alzheimer’s disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect for the success of interventions aimed at slowing down rates of cognitive decline. Recent evidence indicates that of the two established methods for measuring amyloid, a decrease in cerebrospinal fluid (CSF) amyloid β1−42 (Aβ1−42) may be an earlier indicator of Alzheimer’s disease risk than measures of amyloid obtained from Positron Emission Tomography (PET). However, CSF collection is highly invasive and expensive. In contrast, blood collection is routinely performed, minimally invasive and cheap. In this work, we develop a blood-based signature that can provide a cheap and minimally invasive estimation of an individual’s CSF amyloid status using a machine learning approach. We show that a Random Forest model derived from plasma analytes can accurately predict subjects as having abnormal (low) CSF Aβ1−42 levels indicative of AD risk (0.84 AUC, 0.78 sensitivity, and 0.73 specificity). Refinement of the modeling indicates that only APOEε4 carrier status and four plasma analytes (CGA, Aβ1−42, Eotaxin 3, APOE) are required to achieve a high level of accuracy. Furthermore, we show across an independent validation cohort that individuals with predicted abnormal CSF Aβ1−42 levels transitioned to an AD diagnosis over 120 months significantly faster than those with predicted normal CSF Aβ1−42 levels and that the resulting model also validates reasonably across PET Aβ1−42 status (0.78 AUC). This is the first study to show that a machine learning approach, using plasma protein levels, age and APOEε4 carrier status, is able to predict CSF Aβ1−42 status, the earliest risk indicator for AD, with high accuracy.

Published
2019

123. Outcome and patterns of recurrence of nonbilharzial pure squamous cell carcinoma of the bladder: a contemporary review of The University of Texas M. D. Anderson Cancer Center experience

Author

Kassouf, Wassim, Spiess, Philippe E., Siefker-Radtke, Arlene, Swanson, David, Grossman, H. Barton, Kamat, Ashish M., Munsell, Mark F., Guo, Charles C., Czerniak, Bogdan A., and Dinney, Colin P.

Subjects
Bladder cancer -- Care and treatment, Bladder cancer -- Patient outcomes, Cystectomy -- Patient outcomes, Neoadjuvant therapy -- Patient outcomes, Squamous cell carcinoma -- Care and treatment, Squamous cell carcinoma -- Patient outcomes, Cancer -- Relapse, Cancer -- Research, Health
Published
2007

124. Micropapillary bladder cancer: a review of the University of Texas M. D. Anderson Cancer Center experience with 100 consecutive patients

Author

Kamat, Ashish M., Dinney, Colin P.N., Gee, Jason R., Grossman, H. Barton, Siefker-Radtke, Arlene O., Tamboli, Pheroze, Detry, Michelle A., Robinson, Tracy L., and Pisters, Louis L.

Subjects
Bladder cancer -- Care and treatment, Bladder cancer -- Patient outcomes, Bladder cancer -- Research, Adenocarcinoma -- Care and treatment, Adenocarcinoma -- Patient outcomes, Adenocarcinoma -- Research, Cystectomy -- Patient outcomes, Cystectomy -- Research, Health
Published
2007

131. Bladder cancer risk as modified by family history and smoking

Author

Lin, Jie, Spitz, Margaret R., Dinney, Colin P., Etzel, Carol J., Grossman, H. Barton, and Wu, Xifeng

Subjects
Bladder cancer -- Risk factors, Smoking -- Health aspects, Smoking -- Research, Genetic susceptibility -- Research, Health
Published
2006

139. Increased plasma levels of angiogenin and the risk of bladder carcinoma: from initiation to recurrence

Author

Zhao, Hua, Grossman, H. Barton, Delclos, George L., Hwang, Lu-yu, Troisi, Catherine L., Chamberlain, Robert M., Chenoweth, Marsha A., Zhang, Huifeng, Spitz, Margaret R., and Wu, Xifeng

Subjects
Tumors -- Growth, Neovascularization -- Research, Bladder cancer -- Research, Bladder cancer -- Diagnosis, Angiogenin -- Research, Diseases -- Relapse, Tumor markers, Metastasis, Company growth, Health
Published
2005

146. Methyl-CpG-binding domain 2. A protective role in bladder carcinoma

Author

Zhu, Yong, Spitz, Margaret R., Zhang, Hui, Grossman, H. Barton, Frazier, Marsha L., and Wu, Xifeng

Subjects
Bladder cancer -- Genetic aspects, Bladder cancer -- Research, Bladder cancer -- Case studies, Gene expression -- Research, Health
Published
2004

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