Search

In this work we propose an integrated system to manage and enhance the experience of visiting museums for the general public, providing a more comfortable, intelligent and interactive way to visit multiple museums without the need for several mobile applications, whilst giving a quick tool to museum curators that allows them to easily manage and extend the content displayed to each individual visitor. For that purpose, our approach was to develop a single mobile Application, a module to an open-source Content Management System (CMS), namely Drupal 8, and combine them with location information that was inferred by the capture of BLE’s signals (beacons). The proposed prototype features an Android application that will be used by the visitor where they can access the available information about several museums, and combined with BLE’s, will display information about the museum and spaces of the museum where the visitor is (or is planning to visit). This application gives the option to choose from several languages that are provided and managed by each Museum. This management of the museum content to be made available to the Android application is performed using a web-based system, that is a Drupal 8 custom module, and is used by Museums curators, turning this task much simpler.

BACKGROUND: Enteric pathogens have developed mechanisms to disrupt tight junctions and increase gut permeability. Many studies have analysed the ability of live probiotics to protect intestinal epithelial cells against tight junction damage caused by bacterial pathogens. Escherichia coli Nissle 1917 (EcN) is among the probiotics that positively modulates the intestinal epithelial barrier by regulating expression and distribution of tight junction proteins. We previously reported that regulation of ZO-1, claudin-14 and claudin-2 is mediated by EcN secreted factors, either free-released or associated with outer membrane vesicles (OMVs). Factors secreted by commensal ECOR63 elicited comparable effects in intact epithelial T-84 and Caco-2 cell monolayers. RESULTS: Here we analyse the ability of OMVs and soluble secreted factors to protect epithelial barrier function in polarized T-84 and Caco-2 cells infected with enteropathogenic Escherichia coli (EPEC). Transepithelial electrical resistance, paracellular permeability, mRNA levels and subcellular distribution of tight junction proteins were monitored in the absence or presence of EcN and ECOR63 extracellular fractions. EPEC downregulated expression of ZO-1 ZO-2, occludin and claudin-14 and altered the subcellular localization of ZO-1, occludin and F-actin cytoskeleton. OMVs and soluble factors secreted by EcN and ECOR63 counteracted EPEC-altered transepithelial resistance and paracellular permeability, preserved occludin and claudin-14 mRNA levels, retained ZO-1 and occludin at tight junctions in the cell boundaries and ameliorated F-actin disorganization. Redistribution of ZO-1 was not accompanied by changes at mRNA level. CONCLUSION: This study provides new insights on the role of microbiota secreted factors on the modulation of intestinal tight junctions, expanding their barrier-protective effects against pathogen-induced disruption.

In this work, we describe a prototype that was developed as an inte- grated system that provides relevant information in an interactive way when in- side of complex buildings, such as museums, hospitals, shopping malls, amongst others. To accomplish this, the system uses an Indoor Location and Tracking System taking advantage of BLE devices and Bluetooth capabilities of mobile devices. This prototype is also composed of an open-source Content Management System (based on Drupal 8), that allows the system operators to upload and manage the information provided to the mobile users, with the pos- sibility of uploading files extracted from BIM tools. The resulting system is af- fordable for Smart Places while being comfortable and interactive for the users.

RESUMEN Introducción: El objetivo del presente estudio era presentar los resultados clínicos de la carga inmediata de implantes insertados mediante la técnica de cirugía guiada en pacientes edéntulos mandibulares. Pacientes y Métodos: Pacientes edéntulos totales mandibulares fueron diagnosticados mediante una tomografía computarizada de haz cónico y tratados con 8-10 implantes Galimplant ® para su rehabilitación mediante la técnica de cirugía guiada y carga inmediata. Inmediatamente después de la cirugía sin colgajo se colocó una rehabilitación total inmediata provisional de resina. A los 3 meses se realizó la rehabilitación fija definitiva. El periodo de seguimiento clínico ha sido al menos de 48 meses después de la carga funcional. Resultados y Discusión: 24 pacientes fueron tratados con 206 implantes. Desde un punto de vista implantológico, los resultados indican un éxito de los implantes del 97,6% después de un seguimiento clínico medio de 62,4 meses desde la rehabilitación definitiva. 5 implantes se perdieron durante el periodo de cicatrización con la prótesis provisional. La pérdida media de hueso marginal ha sido de 1,34 mm. Los hallazgos clínicos demuestran la eficacia clínica de este protocolo de carga inmediata, donde la estabilidad primaria de los implantes y el ajuste oclusal de la prótesis inmediata son factores determinantes del éxito. Conclusiones: Este estudio indica que el tratamiento de pacientes edéntulos mandibulares con implantes dentales mediante cirugía guiada y carga inmediata constituye una alternativa terapéutica implantológica con una tasa elevada de éxito. ABSTRACT Introduction: The aim of this study was to present the clinical outcomes of immediate loading of implants inserted by guided surgery in edentulous mandibular patients. Patients and methods: Mandibular edentulous patients were diagnosed by a cone beam tomography and treated with 8-10 Galimplant ® implants for rehabilitation with guided surgery and immediate loading. After flapless surgery, implants were loaded with an immediate acrylic temporary prosthesis. After a period of three months, a ceramic definitive full arch prosthesis were placed. The follow-up were at least of 48 months of functional loading. Results and discussion: 24 patients were treated with 206 implants. Clinical outcomes showed a global success of 97.6% of implants after a mean follow-up of 62.4 months. Five implants were lost during the healing phase with provisional prosthesis. Mean marginal bone loss was 1.34 mm. Findings of the study showed clinical efficacy of immediate loading, primary stability and occlusal adjustment of immediate prosthesis are key determinants of success. Conclusions: This study indicate that treatment of mandibular edentulous patients by guided surgery and immediate loading constitute an implant option with a high rate of success.

Background: People with diabetes and kidney disease have a high risk of cardiovascular events and progression of kidney disease. Sodium glucose co-transporter 2 inhibitors lower plasma glucose by reducing the uptake of filtered glucose in the kidney tubule, leading to increased urinary glucose excretion. They have been repeatedly shown to induce modest natriuresis and reduce HbA1c, blood pressure, weight, and albuminuria in patients with type 2 diabetes. However, the effects of these agents on kidney and cardiovascular events have not been extensively studied in patients with type 2 diabetes and established kidney disease. Methods: The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial aims to compare the efficacy and safety of canagliflozin ­versus placebo at preventing clinically important kidney and cardiovascular outcomes in patients with diabetes and established kidney disease. CREDENCE is a randomized, double-blind, event-driven, placebo-controlled trial set in in 34 countries with a projected duration of ∼5.5 years and enrolling 4,401 adults with type 2 diabetes, estimated glomerular filtration rate ≥30 to 2, and albuminuria (urinary albumin:creatinine ratio >300 to ≤5,000 mg/g). The study has 90% power to detect a 20% reduction in the risk of the primary outcome (α = 0.05), the composite of end-stage kidney disease, doubling of serum creatinine, and renal or cardiovascular death. Conclusion: CREDENCE will provide definitive evidence about the effects of canagliflozin on renal (and cardiovascular) outcomes in patients with type 2 diabetes and established kidney disease. Trial Registration: EudraCT number: 2013-004494-28; ClinicalTrials.gov identifier: NCT02065791.

RESUMEN La superficie de los implantes es muy importante para conseguir la oseointegración. Existen muchos tipos de superficies en los implantes dentales. La investigación en superficie de implantes comienza con la superficie mecanizada. La superficie rugosa incrementa la adherencia celular y muestra una mayor área de contacto hueso-implante. El recubrimiento con plasma de titanio e hidroxiapatita fueron métodos comunes para modificar la rugosidad de la superficie. Más recientemente, el arenado (ej. alúmina) y el grabado ácido (ej. chorhídrico, sulfúrico, nítrico) son otros procesos que pueden incrementar la superficie rugosa de los implantes. Más recientemente, la tecnología ha comenzado en la implantología oral con el desarrollo de superficies porosas que manifiestan una mejor respuesta osteogénica e incrementa la unión mecánica hueso-titanio. La oseointegración parece estar influenciada por los modelos de especies animales. En el conejo el proceso es más rápido que en el perro, y en el perro es más rápido que en el hombre. La incorporación de nuevos materiales y procesos técnicos en la investigación sobre superficies de implantes ofrecen nuevas posibilidades de mejorar su respuesta tisular y su potencial óseo regenerativo. Conclusiones. El tratamiento de la superficie de los implantes constituye un importante campo en futuras investigaciones de la implantología oral mediante los estudios de experimentación. SUMMARY Implant surface is very important for enhance the osseointegration. They are many types of dental implant surfaces. Implant surface research begins with machined surface. Roughened surface titanium increase cell adhesion and exhibit stronger bone-implant contact area. Plasma-spray and hydroxyapatite coating were common methods for rough surface modification. Most recently, blasting (i.e. alumina) and acid-etching (i.e. hydrochloric, sulphuric and nitric) are another process by which surface roughness can be increased. Most recently, technology begins in implant dentistry with the development of porous surfaces that manifest better osteogenic response and increase bone-titanium mechanical interlocking. Osseointegration appeared to be strongly influenced by the animal species model. The rabbit model was faster compared to the dog model, and the dog model was faster the human model. The introduction of new materials and new technical process in dental surfaces research offering new possibilities for better tissue response and bone regenerative potential. Conclusions. The surface modifications of titanium constitute an important field for future research of implant dentistry by experimental studies.

RESUMEN Introducción. El objetivo del presente estudio era mostrar los resultados del tratamiento con implantes dentales insertados mediante la técnica de elevación transcrestal en el maxilar superior. Pacientes y Metodos. 47 pacientes (18 hombres y 29 mujeres) con pérdidas dentales maxilares fueron tratados con 60 implantes IPX ® Galimplant con conexión interna y superficie arenada y grabada fueron insertados mediante la técnica de elevación sinusal transcrestal para la rehabilitación del maxilar posterior. Los implantes fueron cargados después de un periodo de cicatrización de 6 meses. Resultados. Los hallazgos clínicos indican una supervivencia y éxito de los implantes del 100%. La ganancia media de hueso vertical fué de 4,8 mm (rango: 2-6,5 mm). 46,7% de los implantes se insertaron en localización molar y el 53,3% en la localización premolar. Biomateriales fueron utilizados en el 91,7% de los implantes. Después de un periodo medio de carga funcional de 37,6 meses (rango: 24-52 meses), no ha habido complicaciones tardías. El 70% de los implantes fueron rehabilitados con coronas unitarias y el 30% con puentes fijos. Conclusiones. Este estudio indica que el tratamiento con implantes dentales mediante su inserción con elevación transcrestal del seno maxilar superior constituye una terapéutica implantológica con éxito. ABSTRACT Introduction. The aim of this study was to report the outcome of treatment with maxillary dental implants inserted by transcrestal sinus elevation. Patients and Methods. 47 patients (18 males and 29 females) with maxillary tooth loss were treated with 60 IPX ® Galimplant internal connection and sandblasted and acid-etched surface implants inserted by transcrestal sinus elevation for rehabilitation of posterior maxilla. Implants were loaded after a healing free-loading period of 6 months. Results. Clinical results indicate a survival and success rate of implants of 100%. The mean elevation height was 4.8 mm (range: 2-6.5 mm). 46.7% of implants were inserted in molar and 53.3% in premolar localization. Bone substitutes were used in 91.7% of implants. After a mean functioning period of 37.6 months (range: 24-52 months), no late complications were reported. 70% of implants were restored with single crowns and 30% with fixed bridges. Conclusions. This study indicate that treatment with dental implants inserted in maxilla by transcrestal sinus elevation constitute a successful implant treatment.

RESUMEN La superficie de los implantes es muy importante para la oseointegración. La superficie rugosa de titanio puede influir en los resultados experimentales y clínicos. Diferentes instrumentos y técnicas de mediciones pueden influir notablemente en los resultados de la caracterización topográfica de los implantes. Las superficies han sido documentadas mediante microscopio electrónico de barrido. La interferometría de luz blanca puede identificar las irregularidades en la superficie por cambios en la luz reflejada. La composición química de las superficies puede ser determinada por la técnica de espectroscopía fotoelectrónica de rayos X. La composición química refleja los procedimientos de la fabricación de los implantes. Una variedad de elementos y compuestos químicos no relacionados con la composición del titanio pueden encontrarse en algunos tipos de implantes; como material inorgánico (ej. cloruro de sodio) y compuestos orgánicos de carbono que pueden deberse a la contaminación durante la fabricación y el almacenaje. Conclusiones. Las modificaciones en la topografía y en la composición química de la superficie de los implantes constituye un importante campo en la implantologia oral experimental y clínica. SUMMARY Implant surface is very important for the osseointegration. Roughened surface titanium may influence in experimental and clinical results. Different measures instruments and techniques strongly influence the outcome of a topographic characterization of surface implant. Surfaces has been documented by scanning electron microscopy. White light interferometer may identify the surface irregularities that cause phase changes in the reflected light. The surfaces chemical composition was determined using a technique of X-ray photoelectron spectroscopy. Chemical composition reflect the type of fabrication procedures applied to implants. A variety of elements and chemical compounds not related to the titanium composition were found on some implant types. They ranged from inorganic material (i.e. sodium chloride) to specific organic as carbon compounds believed to be due to contamination during fabrication or storage. The experimental findings are believed to make a contribution to a better understanding of the interplay between industrial fabrication procedure and physico-chemical implant surface properties. Conclusions. The topographic and chemical composition modifications of surface implants constitute an important field in experimental and clinical implant dentistry.

Voluntary end of male pig castration is expected in the EU in the near future, but standard immunocastration (IC) protocols need to be adapted for Iberian (IB) pig males due to their long life cycle. Our team developed a 3-dose protocol that needs a further adjustment to suit montanera (MT; free-range acorn feeding) chronology. Our hypothesis is that improving homogeneity of body condition at the start of MT will enhance and homogenize testicular atrophy. Pure IB males (n=35) reared in extensive system were feed-restricted during the growth phase (pre-montanera) as usual. Of these animals, Control pigs (C; n=18) were immunized against GnRH at 10.5, 12 and 13.5 months (m)of age. Treated pigs (T; n=17) were immunized at 10.5, 11.5 and 13 m, with a 15-day ad libitum (AL) feeding period starting at the 3rd dose. Both groups started the MT period at 13.5 m, coinciding with the 3rd dose of C and the end of the AL period of T, and both were slaughtered at 16 m. To further validate the effect of nutritional level, an additional group was fed ad libitum during growth and finishing phases with commercial feedstuff in a regular outdoor rearing system (Adlib; n=15 IB x Duroc males), with the vaccinations taking place at 8, 9 and 11 m and slaughter at 13 m (earlier, due to genotype and unrestricted feeding). Testes and epidydimides were significantly smaller in Adlib and T than C pigs. Similarly, bulbourethral glands were significantly smaller in T than C pigs. Testes parenchyme color "a" (green to red) was highly correlated (r=0.87) with testes weight. Backfat androstenone and skatole were below detection limits for all the animals. Foreleg, loin and prime-cut yields were significantly greater for Adlib than for C and T pigs. In conclusion, nutritional level can be used to improve the efficacy of male IC, and testes colorimetry can be used to monitor this efficacy.

RESUMEN Introducción: El objetivo del presente estudio era presentar los resultados clínicos de la carga inmediata de implantes insertados mediante la técnica de cirugía guiada en pacientes edéntulos mandibulares. Pacientes y Métodos: Pacientes edéntulos totales mandibulares fueron diagnosticados mediante una tomografía computarizada de haz cónico y tratados con 8-10 implantes Galimplant ® para su rehabilitación mediante la técnica de cirugía guiada y carga inmediata. Inmediatamente después de la cirugía sin colgajo se colocó una rehabilitación total inmediata provisional de resina. A los 3 meses se realizó la rehabilitación fija definitiva. El periodo de seguimiento clínico ha sido al menos de 48 meses después de la carga funcional. Resultados y Discusión: 24 pacientes fueron tratados con 206 implantes. Desde un punto de vista implantológico, los resultados indican un éxito de los implantes del 97,6% después de un seguimiento clínico medio de 62,4 meses desde la rehabilitación definitiva. 5 implantes se perdieron durante el periodo de cicatrización con la prótesis provisional. La pérdida media de hueso marginal ha sido de 1,34 mm. Los hallazgos clínicos demuestran la eficacia clínica de este protocolo de carga inmediata, donde la estabilidad primaria de los implantes y el ajuste oclusal de la prótesis inmediata son factores determinantes del éxito. Conclusiones: Este estudio indica que el tratamiento de pacientes edéntulos mandibulares con implantes dentales mediante cirugía guiada y carga inmediata constituye una alternativa terapéutica implantológica con una tasa elevada de éxito.

Introduction: Several independent risk factors of Ectopic Pregnancy (EP) have been described to date. Nevertheless, estradiol and progesterone have not been related to ectopic pregnancy, although there is biological rationale to think about them as possible candidates. Our aim was to correlate the incidence of EP with levels of estradiol (E2) and progesterone (P4), measured on two days (hCG day, and seven days later (hCG+7)), including the differences and ratios of these concentrations, between the two time-points. Material and methods: Retrospective cohort study of 578 patients undergoing fresh embryo transfer after IVF (100 cycles), ICSI (508 cycles) and IVF/ICSI (64 cycles) without risk of EP, between January 2005 and December 2015. We evaluated EP incidence (10 ectopic pregnancies) in fresh embryo transfers according to estradiol and progesterone levels on hCG day (hCGd) and seven days later (hCG+7) and their variation between both. The proportions were compared using the chi-square test or Fisher's exact test and the means were compared using T-test or ANOVA. To determine the accuracy of each studied variable receiver-operating curves were built. Results: We identified a trend towards an increased risk of EP as progesterone levels rose on hCGd (p=0.020) and an association of progesterone values >1.89ng/ml on hCGd with EP (OR 6.8). An increased risk of EP when the difference of estradiol between hCGd and hCG+7 was either 745pg/mL (p=0.001) was also found. ROC analysis only resulted significant for a moderate/good predictive ability for progesterone values on hCGd (AUC: 0.694). Discussion: We conclude that these measurements are sufficient to identify patients at a high risk of EP. These hormone levels on specific days, leading us to define proper strategies to prevent EP risks in IVF. Further studies should design to prove this hypothesis.

RESUMEN Introducción. El objetivo del presente estudio era mostrar los resultados del tratamiento con implantes dentales insertados mediante la técnica de elevación transcrestal en el maxilar superior. Pacientes y Metodos. 47 pacientes (18 hombres y 29 mujeres) con pérdidas dentales maxilares fueron tratados con 60 implantes IPX ® Galimplant con conexión interna y superficie arenada y grabada fueron insertados mediante la técnica de elevación sinusal transcrestal para la rehabilitación del maxilar posterior. Los implantes fueron cargados después de un periodo de cicatrización de 6 meses. Resultados. Los hallazgos clínicos indican una supervivencia y éxito de los implantes del 100%. La ganancia media de hueso vertical fué de 4,8 mm (rango: 2-6,5 mm). 46,7% de los implantes se insertaron en localización molar y el 53,3% en la localización premolar. Biomateriales fueron utilizados en el 91,7% de los implantes. Después de un periodo medio de carga funcional de 37,6 meses (rango: 24-52 meses), no ha habido complicaciones tardías. El 70% de los implantes fueron rehabilitados con coronas unitarias y el 30% con puentes fijos. Conclusiones. Este estudio indica que el tratamiento con implantes dentales mediante su inserción con elevación transcrestal del seno maxilar superior constituye una terapéutica implantológica con éxito.

RESUMEN La superficie de los implantes es muy importante para conseguir la oseointegración. Existen muchos tipos de superficies en los implantes dentales. La investigación en superficie de implantes comienza con la superficie mecanizada. La superficie rugosa incrementa la adherencia celular y muestra una mayor área de contacto hueso-implante. El recubrimiento con plasma de titanio e hidroxiapatita fueron métodos comunes para modificar la rugosidad de la superficie. Más recientemente, el arenado (ej. alúmina) y el grabado ácido (ej. chorhídrico, sulfúrico, nítrico) son otros procesos que pueden incrementar la superficie rugosa de los implantes. Más recientemente, la tecnología ha comenzado en la implantología oral con el desarrollo de superficies porosas que manifiestan una mejor respuesta osteogénica e incrementa la unión mecánica hueso-titanio. La oseointegración parece estar influenciada por los modelos de especies animales. En el conejo el proceso es más rápido que en el perro, y en el perro es más rápido que en el hombre. La incorporación de nuevos materiales y procesos técnicos en la investigación sobre superficies de implantes ofrecen nuevas posibilidades de mejorar su respuesta tisular y su potencial óseo regenerativo. Conclusiones. El tratamiento de la superficie de los implantes constituye un importante campo en futuras investigaciones de la implantología oral mediante los estudios de experimentación.