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El chile piquín es una especie que no se cultiva de forma intensiva como cualquier otro cultivo con el que se hace comercio ya que se encuentra de forma silvestre. Este tipo de chile es ampliamente consumido en todo el sureste de México. Para cubrir la demanda, casi la totalidad proviene de recolectas. Nutricionalmente, los frutos son fuente de vitamina A y contienen antioxidantes. Históricamente los pueblos nativos utilizaban el fruto para tratar enfermedades como asma, tos, dolor de garganta, dolores de muelas, entre otras. Diversos artículos señalan que puede llegar a disminuir el riesgo de desarrollar cáncer estomacal, así mismo, puede generar protección estomacal por daño ocasionado por ingesta excesiva de aspirinas. En las cocinas mexicanas el piquín aporta sabor a múltiples recetas, este chile se caracteriza por ser discreto a comparación de otros, de sensación al gusto entre cítrico, ahumado y almendrado, su consumo puede ser verde entero o seco molido para salsas, salmueras y escabeche. La India es el primer competidor directo de México para la exportación de chile piquín hacia Estados Unidos de América, pero China es el principal competidor de producción dentro del mercado interno.

Abstract Dental caries is the major biofilm-mediated oral disease in the world. The main treatment to restore caries lesions consists of the use of adhesive resin composites due to their good properties. However, the progressive degradation of the adhesive in the medium term makes possible the proliferation of cariogenic bacteria allowing secondary caries to emerge. In this study, a dental adhesive incorporating a drug delivery system based on L-arginine-containing mesoporous silica nanoparticles (MSNs) was used to release this essential amino acid as a source of basicity to neutralize the harmful acidic conditions that mediate the development of dental secondary caries. The in vitro and bacterial culture experiments proved that L-arginine was released in a sustained way from MSNs and diffused out from the dental adhesive, effectively contributing to the reduction of the bacterial strains Streptococcus mutans and Lactobacillus casei. Furthermore, the mechanical and bonding properties of the dental adhesive did not change significantly after the incorporation of L-arginine-containing MSNs. These results are yielding glimmers of promise for the cost-effective prevention of secondary caries. Graphical Abstract

Abstract In this manuscript, we present an alternative method for calculating null geodesics in General Static Isotropic Metrics in General Relativity and Extended Theories of Gravity. By applying a conformal transformation, we are able to consider an analogue gravity model, where curvature is encoded in the dielectric and magnetic properties of a medium. In other words, we pass from curved to flat space-times, where instead of the Einstein field equations, the Maxwell equations are solved. Within this geometrical background, the photon geodesics are calculated. Then, given different black hole and wormhole metrics, we apply this method obtaining an excellent agreement with respect to the exact solutions in the original gravity framework by committing angular deviations below $$3^{\circ }$$ 3 ∘ . Finally, we provide the image of a Schwarzschild black hole surrounded by a thin accretion disk, and the apparent image of a Morris and Thorne-like wormhole within an angular discrepancy below $$4^{\circ }$$ 4 ∘ .

Abstract The lack of safe drinking water affects communities in low-to-medium-income countries most. This barrier can be overcome by using sustainable point-of-use water treatments. Solar energy has been used to disinfect water for decades, and several efforts have been made to optimise the standard procedure of solar water disinfection (SODIS process). However, the Health Impact Assessment of implementing advanced technologies in the field is also a critical step in evaluating the success of the optimisation. This work reports a sustainable scaling-up of SODIS from standard 2 L bottles to 25 L transparent jerrycans (TJC) and a 12-month field implementation in four sites of Tigray in Ethiopia, where 80.5% of the population lives without reliable access to safe drinking water and whose initial baseline average rate of diarrhoeal disease in children under 5 years was 13.5%. The UVA dose required for 3-log reduction of E. coli was always lower than the minimum UVA daily dose received in Tigray (9411 ± 55 Wh/m2). Results confirmed a similar decrease in cases of diarrhoea in children in the implementation (25 L PET TJC) and control (2 L PET bottles) groups, supporting the feasibility of increasing the volume of the SODIS water containers to produce safer drinking water with a sustainable and user-friendly process.

La flor de Cempasúchil es originaria de México, siendo muy representativa en las ofrendas para los muertos, su nombre proviene del náhuatl que significa veinte flores o varias flores. En la búsqueda de un sustrato más económico y una alternativa para incrementar la germinación y desarrollo de plantas de cempasúchil, se realizó la presente investigación con el objetivo de determinar si el aserrín, perlita, peat moss, tierra de hoja y la combinación de ellos mejoran la germinación o desarrollo de la planta Cempasúchil. Los siete tratamientos y diez repeticiones generados se sembraron en charolas de 77 cavidades de las cuales solo se utilizó 70 cavidades, los cuales se colocaron en un diseño de bloques completos al azar, utilizando la función de aleatorización del programa “Rstudio”. Los tratamientos que presentaron el mayor porcentaje de germinación son T7 (aserrín 25%, peat moss 25%, perlita 25%, tierra de hoja 25%) y el T6 (aserrín 55%, peat moss 15%, perlita 15%, tierra de hoja 15%). Mientras en la variable desarrollo de la planta de cempasúchil el tratamiento con mejor resultado es el T1 (peat moss 100%) y le sigue el T4 (tierra de hoja 100%).

El proyecto Repensar Extremadura pretende acelerar la transferencia de conocimiento innovador y de transformación de un territorio, en este caso de la región de Extremadura (España). Desde una propuesta novedosa de participación ciudadana basada en la inteligencia colectiva, persigue detectar las nuevas ideas que van surgiendo en diferentes ámbitos, tales como económicos y sociales, e identificar nuevas oportunidades en base al establecimiento de retos presentes y futuros. La finalidad es que las nuevas ideas, desde el contraste académico y científico de la Universidad y de los Centros de Investigación, puedan estudiarse, valorarse y aplicarse en la región de Extremadura (España). Se propone un proceso permanente de reflexión tomando el conocimiento como la base de cualquier progreso social, en la que las instituciones, organizaciones, asociaciones e instituciones civiles desarrollan un papel clave en el proyecto para el establecimiento de nuevos modelos de desarrollo futuros, alineados con la Agenda 2030 para el Desarrollo Sostenible.

Las conductas y actitudes que favorecen el desempeño en una organización, son la causa del éxito de la misma, tal es el caso de la Universidad Autónoma de Tamaulipas (UAT). Se utilizó un estudio cualitativo en el que se analizaron las percepciones de los colaboradores con respecto a las conductas se pueden presentar en la cultura organizacional, a través de una encuesta de respuesta dicotómica con una adaptación de los factores propuestos en el Cuestionario de Conductas Normativas Organizacionales. Como resultado se obtuvo que las conductas en la cultura organizacional en la UAT favorecen el desempeño de sus colaboradores y tienen presencia en más del 70% de la población. Se concluye que los factores calidad, colaboración, consideración, orientación a la autoridad y competición se presentan por encima del umbral del 70% establecido.

Highlights Differences by sex in blood leptin and body fat percentage in children are present before 10 years old Girls have higher circulating leptin and body fat percentage than boys The sex differences in blood leptin and adiposity in children increase progressively with the age

Abstract Amphibians have some of the most variable genome sizes among vertebrates. Genome size variation has been attributed to repetitive and noncoding DNA, including satellite repeats, transposable elements, introns, and nuclear insertions of viral and organelle DNA. In vertebrates, satellite DNAs have been widely described in mammals, but few molecular studies have been carried out in amphibians. Here, we provide a detailed characterization of a new family of satellite DNA, present in all 15 examined species of the family Bufonidae. Southern-blot analysis and PCR reveal that this satellite is formed by monomers of 807 bp, is organized in tandem arrays, and has an AT-content of 57.4%. Phylogenetic analyses show that most clades exhibit species-specific variances, indicating that this satellite DNA has evolved by concerted evolution. The homogenization/fixation process is heterogeneous in Bufonidae, where the genera Bufo and Bufotes do not show species-specific differences, while populations from Rhinella marina exhibit population-specific changes. Additionally, variants of this satellite DNA have been identified in Duttaphrynus melanostictus and R. marina, supporting the ‘library hypothesis’ (a set, ‘library’, of satellite DNAs is shared by a species group). Physical mapping in Bufo bufo, Bufo spinosus, Epidalea calamita and Bufotes viridis provides evidence that this repetitive DNA is not dispersed in the karyotype, but accumulated in pericentromeric regions of some chromosomal pairs. This location, together with its presence in the transcriptomes of bufonids, could indicate a role in centromere function or heterochromatin formation and maintenance.

Aim: To explore trends in multiple sclerosis incidence rates in Spain between 1990 and 2019. Methods: We use data from the Global Burden of Disease Study 2019 to calculate age-standardised incidence rates of multiple sclerosis and identify significant changes over time using the Joinpoint regression model. We also use the Age-Period-Cohort model to understand the separate influences of age, historical period, and birth cohort on these trends. Results: Between 1990 and 2019, Spain reported 31,152 cases of multiple sclerosis, with an average annual growth rate of 1.3%, slightly higher in men (1.40%) than in women (1.28%). Joinpoint analysis revealed non-parallel trends of incidence between sexes, with men experiencing increases and declines along five differentiated periods, while women showed increasing rates until 2015, followed by stabilization. The incidence of multiple sclerosis increased over time in both sexes achieving an average annual increase of 1.6% for men and 1.4% for women. Individuals born in the early to mid-20th century experienced a different trajectory compared to later generations. For both sexes, their MS risk steadily climbed from the mid-20th century, reaching a peak in the 1970s and 1980s for men and potentially later in the 1990s for women. This peak was then followed by a plateauing of risk in subsequent years. Conclusions: Overall, this study offers valuable insights into MS incidence trends in Spain, highlighting sex disparities, age effects, and generational patterns. Further research is needed to understand the complex interplay of age, period, and cohort effects, as well as regional and environmental factors contributing to risk of new cases of multiple sclerosis. [ABSTRACT FROM AUTHOR]

Patients admitted to neonatal intensive care units are up to eight times more likely to experience medication errors than patients admitted to adult intensive care units. Prescribing errors account for up to 74% of medication errors. Electronic prescribing has been postulated as a tool to reduce errors. The objective was to analyse prescribing errors with the e-prescribing system and risk factors. All patients who were admitted for at least 24 h and who received active pharmacological treatment during the study period were included. Prescriptions were made using electronic assisted prescription software integrated into the medical record system. Treatment was reviewed daily by a pharmacist, and errors were graded according to taxonomic criteria. A total of 240 patients were included, 13,876 prescriptions were reviewed and 455 errors were found (3.3% of prescriptions were wrong). Prescribing errors were concentrated in 40 drugs/nutritional products. The most frequent error was a discrepancy between the prescription and the associated text-free field (n = 196). The drugs with the most errors were Lactobacillus acidophilus, caffeine citrate, acetaminophen, gentamycin and cholecalciferol. Patients with a birth weight from 1000 to 1500 g were 82% more likely to experience an error than those with an extremely low birth weight (< 1000 g) (OR = 1.81, 95% CI = 1.42–2.89, p < 0.05). Patients at the highest risk were those with gestational ages from 28 to 32 weeks, with a 29.80% greater risk of prescribing errors than those with gestational ages less than 28 weeks (OR = 1.29, 95% CI = 1.02–1.65, p < 0.05). Prescribing errors occur due to complex dosing rules based on patient characteristics and free-text use, highlighting process issues rather than specific medication risks. [ABSTRACT FROM AUTHOR]

Purpose: To develop a systematic review with meta-analysis to summarize the effectiveness of exercise, regular physical activity, and mind-body exercise on harmful exercise habits, psychological factors, and quality of life in people clinically diagnosed with feeding and eating disorders. Material and methods: Randomized clinical trials and pilot randomized clinical trials were considered. Results: Twelve studies were included. No studies evaluated athletes. No studies examined regular physical activity as the targeted intervention. Quality of life could not be meta-analyzed. Overall, meta-analyses showed that exercise or mind-body exercise was not more effective than controls in reducing depression symptoms, harmful exercise habits, eating behaviors, or emotional regulation skills. However, important methodological and clinical issues were detected in the included studies. This affected the certainty of evidence of the meta-analyzed outcomes which ranged from low to very low. No studies reported in sufficient detail their interventions to be replicated. Conclusions: Overall, exercise and mind-body exercise may be ineffective in improving meta-analyzed outcomes. However, the certainty of evidence ranged from low to very low and the body of knowledge in this field needs to be increased to reach robust conclusions. IMPLICATIONS FOR REHABILITATION: Exercise and mind-boy exercises were not more effective than controls for eating behaviors in eating disorders. Exercise and mind-boy exercises were not more effective than controls for depression symptoms in eating disorders. Clinicians should be aware no specific exercises can be recommended for treating psychological factors in eating disorders. [ABSTRACT FROM AUTHOR]

This dataset originates from TeensLab, a consortium of Spanish Universities dedicated to behavioral research involving Spanish teenagers. The dataset contains data from 33 distinct educational institutions across Spain, accounting for a total of 5,890 students aged 10 to 23 (M = 14.10, SD = 1.94), representing various educational levels such as primary school, secondary school, sixth form and vocational training. The main dimensions covered in this dataset include (i) economic preferences, (ii) cognitive abilities and (iii) strategic thinking. Additionally, a range of supplementary variables is included alongside socio-demographic factors, capturing data on aspects like physical appearance, mood and expectations, among others. [ABSTRACT FROM AUTHOR]

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The lung microbiota is a complex community of microorganisms that colonize the respiratory tract of individuals from, or even before, birth. Although the lungs were traditionally believed to be sterile, recent research has shown that there is a diversity of bacterial species in the respiratory system. Knowledge about the lung microbiota in newborns and its relationship with bacterial infections is of vital importance to understand the pathogenesis of respiratory diseases in neonatal patients undergoing mechanical ventilation. In this article, the current evidence on the composition of the lung microbiota in newborns will be reviewed, as well as the risks that an altered microbiota can impose on premature newborns. Although advances in neonatal intensive care units have significantly improved the survival rate of preterm infants, the diagnosis and treatment of ventilator-associated pneumonia has not progressed in recent decades. Avoiding dysbiosis caused by inappropriate use of antibiotics around birth, as well as avoiding intubation of patients or promoting early removal of endotracheal tubes, are among the most important preventive measures for ventilator-associated pneumonia. The potential benefit of probiotics and prebiotics in preventing infectious, allergic or metabolic complications in the short or long term is not clearly established and constitutes a very important field of research in perinatal medicine.

Quantum transducers are key components for hybrid quantum networks, enabling the transfer of quantum states between microwave and optical photons. In the quantum community, many efforts have focused on creating and verifying the entanglement between microwave and optical fields in systems that typically operate at temperatures in the millikelvin range. Our goal is to develop an integrated microwave optical entanglement device based on a lithium niobate whispering gallery mode resonator (WGMR). To investigate the feasibility of developing such an integrated device, first, a passive photonic integrated circuit (PIC) was designed, fabricated, and characterized. The PIC was developed on a thin-film lithium niobate (TFLN) on an insulator platform, and it includes eight ring resonators and four asymmetric Mach–Zehnder interferometers. This paper presents the design and operational principles of the integrated device for microwave–optical entanglement, as well as the results of the characterization of the passive PIC.

This study introduces the use of a deep convolutional neural network for reconstructing fast-ion velocity distributions from fast-ion loss detectors and imaging neutral particle analyzers (INPAs), automatically integrating uncertainty quantification through Monte Carlo dropout. The network-based reconstructions reveal pitch-angle splitting in high-energy features of lost fast-ion velocity distributions at ASDEX Upgrade during active neutral beam injection, a previously observed phenomenon now confirmed through neural networks. Moreover, contrary to common theories attributing these high-energy features to edge localized mode (ELM)-driven acceleration, we provide experimental evidence that they also occur in type-I ELM-quiescent phases. Additionally, we demonstrate improved reconstructions from INPA measurements, both synthetic and from an ASDEX Upgrade commissioning discharge, with the reconstructions closely matching TRANSP simulations. These findings suggest that neural networks can provide robust reconstructions with well-defined uncertainties, improving the reliability of interpretations of fast-ion behavior in magnetically confined plasmas.

This article presents the methodology and results developed as part of the Integration of Energy Resources through Local Electricity Markets (IREMEL) project, whose aim is to assess the capability of flexibility markets to manage eventual distribution network (DN) congestion produced by a high penetration of distributed energy resources (DERs), including photovoltaic (PV) panels, battery energy storage systems (BESSs), and electric vehicles (EVs). The distribution system simulator OpenDSS has been used to simulate three Spanish DNs under multiple DER penetration scenarios considering an urban and rural low-voltage network and an industrial medium-voltage DN. Likewise, the congestion events detected in the annual simulations have been used to measure the potential of flexibility markets under different DER penetrations and energy pricing. The results suggest that oversized distribution networks could prevent a profitable flexibility market implementation since the simulations developed in this article shows that networks with high congestion levels are prime candidates to solve this issue through a market mechanism. Likewise, the results suggest that a proper price for the energy managed through a local flexibility market (LFM) could have a bigger effect on market viability than DER penetration.

In 2021 JET exploited its unique capabilities to operate with T and D–T fuel with an ITER-like Be/W wall (JET-ILW). This second major JET D–T campaign (DTE2), after DTE1 in 1997, represented the culmination of a series of JET enhancements—new fusion diagnostics, new T injection capabilities, refurbishment of the T plant, increased auxiliary heating, in-vessel calibration of 14 MeV neutron yield monitors—as well as significant advances in plasma theory and modelling in the fusion community. DTE2 was complemented by a sequence of isotope physics campaigns encompassing operation in pure tritium at high T-NBI power. Carefully conducted for safe operation with tritium, the new T and D–T experiments used 1 kg of T (vs 100 g in DTE1), yielding the most fusion reactor relevant D–T plasmas to date and expanding our understanding of isotopes and D–T mixture physics. Furthermore, since the JET T and DTE2 campaigns occurred almost 25 years after the last major D–T tokamak experiment, it was also a strategic goal of the European fusion programme to refresh operational experience of a nuclear tokamak to prepare staff for ITER operation. The key physics results of the JET T and DTE2 experiments, carried out within the EUROfusion JET1 work package, are reported in this paper. Progress in the technological exploitation of JET D–T operations, development and validation of nuclear codes, neutronic tools and techniques for ITER operations carried out by EUROfusion (started within the Horizon 2020 Framework Programme and continuing under the Horizon Europe FP) are reported in (Litaudon et al Nucl. Fusion accepted), while JET experience on T and D–T operations is presented in (King et al Nucl. Fusion submitted).

Fast-ion loss detectors (FILDs) are crucial for analyzing fast-ion dynamics in magnetically confined fusion plasmas. A core challenge is to derive an accurate ion velocity distribution, requiring treatment of thousands of remapped camera frames for a full discharge. The ill-posed nature of this task necessitates regularization with a well-chosen regularization parameter and computationally efficient methods. In this work, we introduce the ‘resolution principle,’ a novel criterion for selecting the optimal regularization parameter, providing a distinction between genuine features and artefacts smaller than the diagnostic resolution in the reconstruction, thereby preventing misinterpretations. This principle, coupled with three iterative reconstruction techniques—Kaczmarz’s method, coordinate descent, and Cimmino’s method—demonstrates enhanced reconstruction capabilities compared to conventional methods like Tikhonov regularization. Utilizing these techniques allows rapid processing of measurements from full discharges, removing the computational bottleneck and facilitating between-discharge reconstructions. By reconstructing 6000 camera frames from an ELMy H-mode discharge at ASDEX Upgrade, we capture the temporal evolution of gyroradii and pitch angles, unveiling a direct correlation between pitch-angle behavior and changes in the toroidal magnetic field for a specific subset of lost ions accelerated by edge-localized modes (ELMs) to energies approximately twice that of the injection energy.

MAST-U is equipped with on-axis and off-axis neutral beam injectors (NBI), and these external sources of super-Alfvénic deuterium fast-ions provide opportunities for studying a wide range of phenomena relevant to the physics of alpha-particles in burning plasmas. The MeV range D-D fusion product ions are also produced but are not confined. Simulations with the ASCOT code show that up to 20% of fast ions produced by NBI can be lost due to charge exchange (CX) with edge neutrals. Dedicated experiments employing low field side (LFS) gas fuelling show a significant drop in the measured neutron fluxes resulting from beam-plasma reactions, providing additional evidence of CX-induced fast-ion losses, similar to the ASCOT findings. Clear evidence of fast-ion redistribution and loss due to sawteeth (ST), fishbones (FB), long-lived modes (LLM), Toroidal Alfvén Eigenmodes (TAE), Edge Localised Modes (ELM) and neoclassical tearing modes (NTM) has been found in measurements with a Neutron Camera (NCU), a scintillator-based Fast-Ion Loss Detector (FILD), a Solid-State Neutral Particle Analyser (SSNPA) and a Fast-Ion Deuterium- α (FIDA) spectrometer. Unprecedented FILD measurements in the range of 1–2 MHz indicate that fast-ion losses can be also induced by the beam ion cyclotron resonance interaction with compressional or global Alfvén eigenmodes (CAEs or GAEs). These results show the wide variety of scenarios and the unique conditions in which fast ions can be studied in MAST-U, under conditions that are relevant for future devices like STEP or ITER.