101. Associations of C-reactive protein and fibrinogen with mortality from all-causes, cardiovascular disease and cancer among U.S. adults
- Author
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Jiting Xu, Yanan Zhang, Fred K. Tabung, Junxiu Liu, Lixia He, Carl J. Lavie, Yunxiang Zhang, and Qingwei Hu
- Subjects
Adult ,Male ,medicine.medical_specialty ,National Health and Nutrition Examination Survey ,Epidemiology ,Disease ,Fibrinogen ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Neoplasms ,Medicine ,Humans ,030212 general & internal medicine ,0101 mathematics ,Proportional Hazards Models ,biology ,business.industry ,010102 general mathematics ,C-reactive protein ,Hazard ratio ,Public Health, Environmental and Occupational Health ,Cancer ,medicine.disease ,Nutrition Surveys ,C-Reactive Protein ,Quartile ,Cardiovascular Diseases ,Cohort ,biology.protein ,Female ,business ,medicine.drug - Abstract
C-reactive protein (CRP) and fibrinogen are associated with an increased risk of death with suggested differences by gender, diet quality and race/ethnicity. However, the current evidence is limited. We used data including 8646 men and 9880 women from the National Health and Nutrition Examination Survey (NHANES) Linked Morality cohort (1999–2011) to investigate the associations of CRP and fibrinogen with mortality overall and by gender, race/ethnicity and diet quality. Cox-proportional hazard model was used to quantify the associations. With a median follow-up of 6 years, a strong dose-response relationship was observed between CRP levels and mortality risk in men after multivariable adjustment. For subjects who survived the first two years, the adjusted hazard ratios (HRs) for total mortality across quartiles (from lower to higher) of CRP were 1.97 (95% CI: 0.62–6.33), 1.89 (0.59, 6.06) and 6.34 (2.28–17.7) (P for trend
- Published
- 2019