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Post-cancer diagnosis dietary inflammatory potential is associated with survival among women diagnosed with colorectal cancer in the Women's Health Initiative
- Source :
- Eur J Nutr
- Publication Year :
- 2018
-
Abstract
- PURPOSE: Dietary factors may influence colorectal cancer (CRC) survival through effects on inflammation. We examined the association between post-CRC diagnosis inflammatory potential of diet and all-cause and cancer-specific mortality in the Women’s Health Initiative. METHODS: The study included 463 postmenopausal women who developed CRC during follow-up and completed a food frequency questionnaire (FFQ), on average 1.7 years after diagnosis. Women were followed from CRC diagnosis until death, censoring, or the end of follow up in October 2014. Energy-adjusted dietary inflammatory index (E-DII)® scores were calculated from the FFQ and dietary supplement inventory. Cox proportional hazards models were fitted to estimate multivariable-adjusted HRs and 95% confidence intervals (CI) for all-cause, total cancer, and CRC-specific mortality with the most pro-inflammatory E-DII scores (tertile 3) as referent. RESULTS: After a median 11.6 years of follow-up, 162 deaths occurred, including 77 from CRC. Lowest tertile (i.e., most anti-inflammatory) E-DII scores from diet plus supplements were associated with significantly lower all-cause mortality (HR(T1vsT3)=0.49; 95% CI=0.31–0.79) compared to the most pro-inflammatory E-DII tertile. Modest associations with total cancer mortality or CRC-specific mortality were observed, though 95%CIs included 1. CONCLUSIONS: Consuming a dietary pattern and supplements with more anti-inflammatory potential after CRC diagnosis may improve overall survival among postmenopausal women.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Colorectal cancer
Medicine (miscellaneous)
030209 endocrinology & metabolism
Comorbidity
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Surveys and Questionnaires
medicine
Humans
Aged
Inflammation
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Proportional hazards model
Women's Health Initiative
Cancer
Dietary pattern
medicine.disease
Survival Analysis
Confidence interval
United States
Diet
Postmenopause
Censoring (clinical trials)
Women's Health
Female
business
Colorectal Neoplasms
Cohort study
Follow-Up Studies
Subjects
Details
- ISSN :
- 14366215
- Volume :
- 59
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- European journal of nutrition
- Accession number :
- edsair.doi.dedup.....baa0fef35439acf16461cb3aa7ded637