136 results on '"Eric Müller"'
Search Results
102. Pattern representation and recognition with accelerated analog neuromorphic systems
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D. Stockel, Ilja Bytschok, Dan Husmann, Mihai A. Petrovici, Johannes Bill, Johannes Schemmel, Maurice Güttler, Karlheinz Meier, Oliver Breitwieser, Wolfgang Maass, Robert Legenstein, Eric Müller, Johannes Partzsch, Anand Subramoney, Christian Mayr, Andreas Hartel, Anna Schroeder, Stephan Hartmann, Andreas Grübl, Alexander Kononov, Stefan Schiefer, Kai Husmann, Guillaume Bellec, Mitja Kleider, Johann Klähn, Stefan Scholze, Vitali Karasenko, Sebastian Schmitt, V. Thanasoulis, Christian Mauch, Paul Müller, Rene Schuffny, Bernhard Vogginger, Sebastian Jeltsch, Christoph Koke, and Thomas Pfeil
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0301 basic medicine ,FOS: Computer and information sciences ,Computer science ,Distributed computing ,Central nervous system ,Machine Learning (stat.ML) ,02 engineering and technology ,03 medical and health sciences ,Robustness (computer science) ,Statistics - Machine Learning ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Neural and Evolutionary Computing (cs.NE) ,Representation (mathematics) ,610 Medicine & health ,Artificial neural network ,business.industry ,020208 electrical & electronic engineering ,Computer Science - Neural and Evolutionary Computing ,030104 developmental biology ,medicine.anatomical_structure ,Neuromorphic engineering ,Quantitative Biology - Neurons and Cognition ,FOS: Biological sciences ,Key (cryptography) ,Neurons and Cognition (q-bio.NC) ,Artificial intelligence ,business - Abstract
Despite being originally inspired by the central nervous system, artificial neural networks have diverged from their biological archetypes as they have been remodeled to fit particular tasks. In this paper, we review several possibilites to reverse map these architectures to biologically more realistic spiking networks with the aim of emulating them on fast, low-power neuromorphic hardware. Since many of these devices employ analog components, which cannot be perfectly controlled, finding ways to compensate for the resulting effects represents a key challenge. Here, we discuss three different strategies to address this problem: the addition of auxiliary network components for stabilizing activity, the utilization of inherently robust architectures and a training method for hardware-emulated networks that functions without perfect knowledge of the system's dynamics and parameters. For all three scenarios, we corroborate our theoretical considerations with experimental results on accelerated analog neuromorphic platforms., Comment: accepted at ISCAS 2017
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- 2017
- Full Text
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103. 'When Was This Picture Taken?' – Image Date Estimation in the Wild
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Ralph Ewerth, Eric Müller, and Matthias Springstein
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Estimation ,Computer science ,business.industry ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Contrast (statistics) ,Pattern recognition ,02 engineering and technology ,Color photography ,Convolutional neural network ,Regression ,Task (project management) ,law.invention ,Image (mathematics) ,law ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Artificial intelligence ,Baseline (configuration management) ,business - Abstract
The problem of automatically estimating the creation date of photos has been addressed rarely in the past. In this paper, we introduce a novel dataset Date Estimation in the Wild for the task of predicting the acquisition year of images captured in the period from 1930 to 1999. In contrast to previous work, the dataset is neither restricted to color photography nor to specific visual concepts. The dataset consists of more than one million images crawled from Flickr and contains a large number of different motives. In addition, we propose two baseline approaches for regression and classification, respectively, relying on state-of-the-art deep convolutional neural networks. Experimental results demonstrate that these baselines are already superior to annotations of untrained humans.
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- 2017
104. Semi-supervised Identification of Rarely Appearing Persons in Video by Correcting Weak Labels
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Eric Müller, Christian Otto, and Ralph Ewerth
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021110 strategic, defence & security studies ,Training set ,Computer science ,Speech recognition ,0211 other engineering and technologies ,02 engineering and technology ,Semi-supervised learning ,Identification (information) ,Annotation ,Character (mathematics) ,Face (geometry) ,0202 electrical engineering, electronic engineering, information engineering ,Identity (object-oriented programming) ,020201 artificial intelligence & image processing ,State (computer science) - Abstract
Some recent approaches for character identification in movies and TV broadcasts are realized in a semi-supervised manner by assigning transcripts and/or subtitles to the speakers. However, the labels obtained in this way achieve only an accuracy of $80\% - 90\%$ and the number of training examples for the different actors is unevenly distributed. In this paper, we propose a novel approach for person identification in video by correcting and extending the training data with reliable predictions to reduce the number of annotation errors. Furthermore, the intra-class diversity of rarely speaking characters is enhanced. To address the imbalance of training data per person, we suggest two complementary prediction scores. These scores are also used to recognize whether or not a face track belongs to a (supporting) character whose identity does not appear in the transcript etc. Experimental results demonstrate the feasibility of the proposed approach, outperforming the current state of the art.
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- 2016
105. Der Wurm und die Halbkreisscheibe
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Eric Müller
- Abstract
Bei der vierten Aufgabe der 2. Runde des Bundeswettbewerbs Mathematik 1990, die mehrheitlich als die schonste aller jemals gestellten Aufgaben beurteilt worden ist, war zu zeigen, dass man jeden Wurm der Lange 1 in der Ebene mit einer Halbkreisscheibe mit dem Durchmesser 1 zudecken kann. Der Beitrag stellt einen kurzen Beweis dieser Aussage mit Hilfe des Spiegelungsprinzips vor und schlagt eine Brucke zu verwandten Problemen, u. a. dem ungelosten Wurmproblem von Leo Moser, und enthalt eine entsprechende Aussage fur Wurmer im Raum.
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- 2016
106. Ziffernreduzierte Zahlen
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Robert Strich and Eric Müller
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- 2016
107. Harmonische Partitionen
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Eric Müller
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- 2016
108. Verfolgungsjagd
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Eric Müller
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- 2016
109. Wie beliebt sind Endziffern bei Teilern?
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Eric Müller
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In der vierten Aufgabe der 1. Runde des Bundeswettbewerbs Mathematik 2001 war zu zeigen, dass jede naturliche Zahl mindestens so viele Teiler mit der Endziffer 1 oder 9 wie Teiler mit den Endziffern 3 oder 7 hat. Der Artikel beweist daneben eine entsprechende Aussage bezuglich der Endziffern 2, 8, 4, 6 und bestimmt allgemeiner – zunachst experimentell computerunterstutzt und dann durch Beweise, wie haufig Teiler mit gewisser Endziffer unter den Teilern einer naturlichen Zahl durchschnittlich vorkommen. Die Beweise enthalten zum Teil ungewohnliche und interessante Anwendungen hoherer Hilfsmittel wie der Potenzreihe fur den naturlichen Logarithmus und dem Satz von Dirichlet uber Primzahlen in arithmetischen Folgen.
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- 2016
110. Some Polynomially Recursive Sequences and Combinatorial Identities
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Earl J. Taft and Eric Müller
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Discrete mathematics ,Sequence ,Algebra and Number Theory ,Mathematics::Rings and Algebras ,Coproduct ,Bialgebra ,Interpretation (model theory) ,Combinatorial principles ,Combinatorics ,Identity (mathematics) ,Mathematics::Category Theory ,Mathematics::Quantum Algebra ,Combinatorial explosion ,Mathematics ,Variable (mathematics) - Abstract
A polynomially recursive sequence satisfies a recursive relation with variable coefficients. The set of these sequences has the structure of a topological bialgebra. If such a sequence is of a combinatorial nature, a formula for its coproduct can (upon appropriate evaluation) be interpreted as a combinatorial identity. Here we give a coproduct formula for each sequence , one for each t ≥ 0, and its interpretation as a combinatorial identity. We also obtain a q-version of this coproduct formula and combinatorial identity.
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- 2011
111. Contribution à l‘étude des groupes sanguins de la race tachetée rouge du Simmental
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Eric Müller
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Food Animals ,Animal Science and Zoology ,Biology ,Molecular biology - Published
- 2010
112. 49. Internationale Mathematik-Olympiade. Madrid 2008
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Hans-Dietrich Gronau and Eric Müller
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General Engineering - Published
- 2008
113. Relational and Algebraic Methods in Computer Science : 14th International Conference, RAMiCS 2014, Marienstatt, Germany, April 28 -- May 1, 2014, Proceedings
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Peter Höfner, Peter Jipsen, Wolfram Kahl, Martin Eric Müller, Peter Höfner, Peter Jipsen, Wolfram Kahl, and Martin Eric Müller
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- Machine theory, Computer science—Mathematics, Computer science, Software engineering, Artificial intelligence, Discrete mathematics
- Abstract
This book constitutes the proceedings of the 14th International Conference on Relational and Algebraic Methods in Computer Science, RAMiCS 2014 held in Marienstatt, Germany, in April/May 2014.The 25 revised full papers presented were carefully selected from 37 submissions. The papers are structured in specific fields on concurrent Kleene algebras and related formalisms, reasoning about computations and programs, heterogeneous and categorical approaches, applications of relational and algebraic methods and developments related to modal logics and lattices.
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- 2014
114. Exciton binding energy limitations in organic materials and potentials for improvements (Presentation Recording)
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Reinhard Scholz, Karl Leo, Martin Knupfer, Christian Koerner, Eric Müller, and Stefan Kraner
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Condensed Matter::Materials Science ,Organic solar cell ,Chemistry ,Electron energy loss spectroscopy ,Exciton ,Binding energy ,Energy conversion efficiency ,Shockley–Queisser limit ,Dielectric ,Atomic physics ,Absorption (electromagnetic radiation) - Abstract
In current organic photovoltaic devices, the loss in energy caused by the inevitable charge transfer step leads to a low open circuit voltage, which is one of the main reasons for rather low power conversion efficiencies. A possible approach to avoid these losses is to tune the exciton binding energy below 25 meV, which would lead to free charges upon absorption of a photon, and therefore increase the power conversion efficiency towards the Shockley Queisser limit for inorganic solar cells. We determine the size of the excitons for different one-dimensional organic small molecules or polymers by electron energy loss spectroscopy (EELS) measurements and by DFT calculations. Using the measured dielectric constant and exciton extension, the exciton binding energy is calculated for the investigated molecules, leading to a lower limit of the exciton binding energy for ladder-type polymers. We discuss and propose potential ways to increase the ionic and electronic part of the dielectric function in order to further lower the limit of the exciton binding energy in organic materials. Furthermore, the influence of charge transfer states on the exciton size and its binding energy is calculated with DFT methods for the ladder-type polymer poly(benzimidazobenzophenanthroline) (BBL) in a dimer configuration.
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- 2015
115. Relational and algebraic methods in computer science
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Peter Jipsen, Wolfram Kahl, Martin Eric Müller, and Peter Höfner
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Logic ,Computer science ,Programming language ,Computation ,computer.software_genre ,Rotation formalisms in three dimensions ,Theoretical Computer Science ,Algebra ,Relational calculus ,Modal ,Computational Theory and Mathematics ,Algebraic number ,Categorical variable ,computer ,Software - Abstract
This book constitutes the proceedings of the 14th International Conference on Relational and Algebraic Methods in Computer Science, RAMiCS 2014 held in Marienstatt, Germany, in April/May 2014. The 25 revised full papers presented were carefully selected from 37 submissions. The papers are structured in specific fields on concurrent Kleene algebras and related formalisms, reasoning about computations and programs, heterogeneous and categorical approaches, applications of relational and algebraic methods and developments related to modal logics and lattices.
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- 2016
116. Bialgebras of Recursive Sequences and Combinatorial Identities
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Earl J. Taft, Eric Müller, and Carl A. Futia
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Sequence ,Recursion ,Relation (database) ,Applied Mathematics ,Mathematics::Rings and Algebras ,Coproduct ,Bialgebra ,Ground field ,Combinatorics ,Recursive set ,Mathematics::Category Theory ,Mathematics::Quantum Algebra ,Order (group theory) ,Mathematics - Abstract
A recursive sequence is an infinite sequence of elements of some fixed ground field which satisfies a recursion relation of finite order. We shall investigate certain bialgebra structures on linear spaces of recursive sequences. By choosing appropriate bases for these bialgebras we show how an explicit formula for the coproduct can imply interesting combinatorial identities.
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- 2002
117. Demonstrating Analog Inference on the BrainScaleS-2 Mobile System
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Yannik Stradmann, Sebastian Billaudelle, Oliver Breitwieser, Falk Leonard Ebert, Arne Emmel, Dan Husmann, Joscha Ilmberger, Eric Muller, Philipp Spilger, Johannes Weis, and Johannes Schemmel
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Accelerator ,analog computing ,convolutional deep neural networks ,electrocardiography ,inference ,low-power ,Electric apparatus and materials. Electric circuits. Electric networks ,TK452-454.4 - Abstract
We present the BrainScaleS-2 mobile system as a compact analog inference engine based on the BrainScaleS-2 ASIC and demonstrate its capabilities at classifying a medical electrocardiogram dataset. The analog network core of the ASIC is utilized to perform the multiply-accumulate operations of a convolutional deep neural network. At a system power consumption of 5.6W, we measure a total energy consumption of $\mathrm {192 ~\mu \text {J} }$ for the ASIC and achieve a classification time of 276 $\mu$ s per electrocardiographic patient sample. Patients with atrial fibrillation are correctly identified with a detection rate of (93.7 ± 0.7)% at (14.0 ± 1.0)% false positives. The system is directly applicable to edge inference applications due to its small size, power envelope, and flexible I/O capabilities. It has enabled the BrainScaleS-2 ASIC to be operated reliably outside a specialized lab setting. In future applications, the system allows for a combination of conventional machine learning layers with online learning in spiking neural networks on a single neuromorphic platform.
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- 2022
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118. Cryogenic and radiation hard ASIC design for large format NIR/SWIR detector
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Geert Verbruggen, Eric Müller, Ramses Valvekens, Benoit Dupont, Bart Dierickx, Stijn Gielis, and Peng Gao
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Signal processing ,Engineering ,Physics::Instrumentation and Detectors ,business.industry ,Detector ,Astrophysics::Instrumentation and Methods for Astrophysics ,Electrical engineering ,Large format ,Application-specific integrated circuit ,EMI ,Interfacing ,Electronic engineering ,Image sensor ,business ,Electronic circuit - Abstract
An ASIC is developed to control and data quantization for large format NIR/SWIR detector arrays. Both cryogenic and space radiation environment issue are considered during the design. Therefore it can be integrated in the cryogenic chamber, which reduces significantly the vast amount of long wires going in and out the cryogenic chamber, i.e. benefits EMI and noise concerns, as well as the power consumption of cooling system and interfacing circuits. In this paper, we will describe the development of this prototype ASIC for image sensor driving and signal processing as well as the testing in both room and cryogenic temperature.
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- 2014
119. COSEMISIMPLE HOPF ALGEBRAS AND THE FRT CONSTRUCTION
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Eric Müller
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Algebra ,Algebra and Number Theory ,Quantum group ,Representation theory of Hopf algebras ,Quasitriangular Hopf algebra ,Hopf algebra ,Quantum ,Mathematics - Abstract
Since the quantum groups have been invented by Drinfel'd [5], they have mainly been considered from two directions: deformations (or quantizations) of universal enveloping algebras of complex semis...
- Published
- 2001
120. Finite Subgroups of the Quantum General Linear Group
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Eric Müller
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Algebra ,Quantum affine algebra ,Quantum group ,General Mathematics ,General linear group ,Representation theory of Hopf algebras ,Hopf algebra ,Quasitriangular Hopf algebra ,Quantum ,Mathematics - Published
- 2000
121. The coradical filtration ofUq(g)at roots of unity
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Eric Müller
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Symmetric algebra ,Discrete mathematics ,Pure mathematics ,Algebra and Number Theory ,Quantum group ,Mathematics::Rings and Algebras ,Universal enveloping algebra ,Lie superalgebra ,Casimir element ,Graded Lie algebra ,Filtered algebra ,Mathematics::Quantum Algebra ,Cellular algebra ,Mathematics - Abstract
We compute the coradical filtration and the group of Hopf algebra automorphisms of the non-restricted specialization of the quantized universal enveloping algebra of a finite-dimensional semisimple Lie algebra.
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- 2000
122. Some Topics on Frobenius–Lusztig Kernels, II
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Eric Müller
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Algebra and Number Theory ,quasitriangular structures ,Mathematics::Category Theory ,Mathematics::Quantum Algebra ,Frobenius–Lusztig kernels ,Mathematics::Rings and Algebras ,ribbon elements ,Mathematics::Representation Theory ,half quantum groups ,sub-Hopf algebras - Abstract
We discuss a method to classify all Hopf subalgebras of a certain class of pointed Hopf algebras including quantized universal enveloping algebras and Frobenius–Lusztig kernels. We find factor Hopf algebras of the dual quotients of the coordinate rings of quantumGL(n). We consider a large class of quasitriangular structures for the Frobenius–Lusztig kernels and compute ribbon elements
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- 1998
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123. RFID–ERP Key Data Integration Challenges
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Luca Canetta, Andrea Salvade, Eric Müller, Pierre Alain Schnegg, and Matteo Lanini
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Process management ,Product life-cycle management ,Computer-integrated manufacturing ,Computer science ,Integrated Computer-Aided Manufacturing ,Supply chain ,Production engineering ,Advanced manufacturing ,Context (language use) ,computer.software_genre ,computer ,Data integration - Abstract
This chapter provides an overview of the potential utilisation of RFID in the manufacturing context. More specifically the specificity of RFID applications, in terms of application fields, objectives, drivers, potential benefits, are analysed for various manufacturing strategies. The characteristics of the market context and of the structure of the manufacturing/assembly system having a significant impact on RFID application are identified and their influence described. An extensive review of industrial case studies classified according to the various manufacturing typologies (ETO, MTO, ATO, MTS, Retailing & Distribution) is provided. This allows to better assess the steps to be undertaken for developing a successful RFID applications, understand the activities to be included, identify the challenges, estimate the potential benefits and the required investments.
- Published
- 2011
124. A comprehensive workflow for general-purpose neural modeling with highly configurable neuromorphic hardware systems
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Daniel Brüderle, Sebastian Millner, Tobias C. Potjans, J. Fieres, Sebastian Jeltsch, Bernhard Vogginger, Dan Husmann de Oliveira, Thomas Pfeil, Andrew P. Davison, Andreas Grübl, Mihai A. Petrovici, Eric Müller, Johannes Schemmel, Anders Lansner, Pradeep Krishnamurthy, Jens Kremkow, Karlheinz Meier, Paul Müller, Matthias Ehrlich, Rene Schuffny, Lyle Muller, Johannes Partzsch, Marc-Olivier Schwartz, Markus Diesmann, Moritz Schilling, Lukas Zühl, Eilif Muller, Oliver Breitwieser, Karsten Wendt, Mikael Lundqvist, Venelin Petkov, Alain Destexhe, Christian Mayr, Stefan Scholze, Kirchhoff Institut für Physik, Universität Heidelberg [Heidelberg], Institute of Circuits and Systems [Dresden] (ICS), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Unité de Neurosciences Information et Complexité [Gif sur Yvette] (UNIC), Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie Alfred Fessard (INAF), Royal Institute of Technology [Stockholm] (KTH ), Computational Biology, Royal Institute of Technology (KTH), Bernstein Center Freiburg (BCF), Albert-Ludwigs-Universität Freiburg, Brain and Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Bernstein Center for Computational Neuroscience, RIKEN Center for Computational Science [Kobe] (RIKEN CCS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), and Institute of Neuroscience and Medicine, Research Center Jülich (INM-6)
- Subjects
MESH: Computers ,General Computer Science ,Computer science ,Process (engineering) ,Signal Propagation ,Interface (computing) ,Chip ,Neocortex ,PyNN ,02 engineering and technology ,Nervous System ,Vlsi ,Abstraction layer ,03 medical and health sciences ,Hardware ,0302 clinical medicine ,Software ,Spiking Neurons ,Neuromorphic ,0202 electrical engineering, electronic engineering, information engineering ,MESH: Models, Theoretical ,Visual-Cortex ,Inhibition ,MESH: Nervous System ,business.industry ,Computers ,Modeling ,Wafer scale ,computer.file_format ,Models, Theoretical ,Network Model ,Workflow ,Computer architecture ,Neuromorphic engineering ,Computational neuroscience ,FOS: Biological sciences ,Quantitative Biology - Neurons and Cognition ,Timing-Dependent Plasticity ,Design process ,Neurons and Cognition (q-bio.NC) ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,020201 artificial intelligence & image processing ,Executable ,business ,computer ,030217 neurology & neurosurgery ,Synaptic Plasticity ,Biotechnology - Abstract
International audience; In this article, we present a methodological framework that meets novel requirements emerging from upcoming types of accelerated and highly configurable neuromorphic hardware systems. We describe in detail a device with 45 million programmable and dynamic synapses that is currently under development, and we sketch the conceptual challenges that arise from taking this platform into operation. More specifically, we aim at the establishment of this neuromorphic system as a flexible and neuroscientifically valuable modeling tool that can be used by non-hardware experts. We consider various functional aspects to be crucial for this purpose, and we introduce a consistent workflow with detailed descriptions of all involved modules that implement the suggested steps: The integration of the hardware interface into the simulator-independent model description language PyNN; a fully automated translation between the PyNN domain and appropriate hardware configurations; an executable specification of the future neuromorphic system that can be seamlessly integrated into this biology-to-hardware mapping process as a test bench for all software layers and possible hardware design modifications; an evaluation scheme that deploys models from a dedicated benchmark library, compares the results generated by virtual or prototype hardware devices with reference software simulations and analyzes the differences. The integration of these components into one hardware-software workflow provides an ecosystem for ongoing preparative studies that support the hardware design process and represents the basis for the maturity of the model-to-hardware mapping software. The functionality and flexibility of the latter is proven with a variety of experimental results.
- Published
- 2010
125. Simulator-like exploration of cortical network architectures with a mixed-signal VLSI system
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Karlheinz Meier, Johannes Schemmel, Daniel Briiderle, Johannes Bill, Bernhard Kaplan, Eric Müller, and Jens Kremkow
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Very-large-scale integration ,Network architecture ,Computer architecture ,Cortical network ,Computer science ,Mixed signal vlsi ,Variety (cybernetics) - Abstract
In this paper we describe our approach towards highly configurable neuromorphic hardware systems that serve as useful and flexible tools in modeling neuroscience. We utilize a mixed-signal VLSI model that implements a massively accelerated network of spiking neurons, and we describe a novel methodological framework that allows to exploit both the speed and the programmability of this device for the systematic and simulator-like exploration of cortical network architectures. We present a variety of experimental results that illustrate the functionality of our modeling platform, and we verify all hardware measurements with reference software simulations. Especially on the network level these comparison studies are unique in terms of the quantitative correspondence between the data. The presented hardware experiments include high-conductance states in hardware neurons and the application of synaptic depression and facilitation for self-adjusting network architectures.
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- 2010
126. Cryosurgery of Lentigo Maligna
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Kornelia Böhler-Sommeregger, Reinhard Neumann, Sanja Schuller-Petrovic, and Eric Müller
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Scars ,Lentigo maligna ,Cryosurgery ,Necrosis ,medicine ,Edema ,Humans ,Nevus ,Lentigo maligna melanoma ,Melanoma ,Lentigo ,Pigmentation disorder ,Aged ,business.industry ,Middle Aged ,medicine.disease ,Dermatology ,Female ,Surgery ,Lentiginosis ,Facial Neoplasms ,Neoplasm Recurrence, Local ,medicine.symptom ,business ,Facial Dermatoses ,Follow-Up Studies - Abstract
Lentigo maligna denotes flat, pigmented lesions predominantly in areas of actinic damage that have the propensity to become malignant. More than 10 years may pass before lentigo maligna evolves into an invasive neoplasma. As an invasive process, it is termed lentigo maligna melanoma (LMM), and it has the potential for both lymphatic and hematogenic metastases. Because of the size and location of the lesions, cosmetically unsatisfactory scars may result from conventional surgery. Therefore, alternative means of treatment, including cryosurgery, have been employed. We report on 12 patients suffering from lentigo maligna who had been treated successfully by cryosurgery between 1984 and 1990. The average follow-up period was 51.4 months, and the recurrence rate was 8.3 percent. Knowing that microinvasive components can be demonstrated in 15 percent of lentigo maligna lesions, we retrospectively reassessed our patients by immunohistochemical procedures with S-100 protein. Although intradermal microinvasion could be confirmed in one patient, no recurrence had been observed within 61 months of follow-up. Provided that patients are selected properly and extension of cryonecrosis is monitored, cryosurgery may prove an efficient alternative to conventional surgery in the treatment of lentigo maligna.
- Published
- 1992
127. Establishing a Novel Modeling Tool: A Python-Based Interface for a Neuromorphic Hardware System
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Johannes Schemmel, Andrew P. Davison, Eric Müller, Karlheinz Meier, Eilif Muller, Daniel Brüderle, Kirchhoff Institute for Physics, University of Heidelberg, Unité de neurosciences intégratives et computationnelles (UNIC), Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie Alfred Fessard (INAF), Laboratory of Computational Neuroscience (LCN - EPFL), and Ecole Polytechnique Fédérale de Lausanne (EPFL)-Laboratory of Computational Neuroscience
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Computer science ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,Biomedical Engineering ,Neuroscience (miscellaneous) ,02 engineering and technology ,neuromorphic ,PyNN ,lcsh:RC321-571 ,03 medical and health sciences ,Software portability ,0302 clinical medicine ,Software ,0202 electrical engineering, electronic engineering, information engineering ,Hardware compatibility list ,hardware ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Simulation ,computer.programming_language ,Original Research ,Hardware architecture ,Very-large-scale integration ,Emulation ,computational ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,business.industry ,software ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,modeling ,Python (programming language) ,Computer Science Applications ,VLSI ,Computer architecture ,Neuromorphic engineering ,020201 artificial intelligence & image processing ,business ,computer ,030217 neurology & neurosurgery ,computational neuroscience ,Neuroscience ,Python - Abstract
International audience; Neuromorphic hardware systems provide new possibilities for the neuroscience modeling community. Due to the intrinsic parallelism of the micro-electronic emulation of neural computation, such models are highly scalable without a loss of speed. However, the communities of software simulator users and neuromorphic engineering in neuroscience are rather disjoint. We present a software concept that provides the possibility to establish such hardware devices as valuable modeling tools. It is based on the integration of the hardware interface into a simulator-independent language which allows for unified experiment descriptions that can be run on various simulation platforms without modification, implying experiment portability and a huge simplification of the quantitative comparison of hardware and simulator results. We introduce an accelerated neuromorphic hardware device and describe the implementation of the proposed concept for this system. An example setup and results acquired by utilizing both the hardware system and a software simulator are demonstrated.
- Published
- 2009
128. Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism
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Hyung-Goo Kim, Jill A. Rosenfeld, Daryl A. Scott, Gerard Bénédicte, Jonathan D. Labonne, Jason Brown, Marianne McGuire, Sonal Mahida, Sakkubai Naidu, Jacqueline Gutierrez, Gaetan Lesca, Vincent des Portes, Ange-Line Bruel, Arthur Sorlin, Fan Xia, Yline Capri, Eric Muller, Dianalee McKnight, Erin Torti, Franz Rüschendorf, Oliver Hummel, Zeyaul Islam, Prasanna R. Kolatkar, Lawrence C. Layman, Duchwan Ryu, Il-Keun Kong, Suneeta Madan-Khetarpal, and Cheol-Hee Kim
- Subjects
PHF21A ,BHC80 ,Intellectual disability (ID) ,Autism spectrum disorder (ASD) ,Neurodevelopmental disorders ,Potocki-Shaffer syndrome (PSS) ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background PHF21A has been associated with intellectual disability and craniofacial anomalies based on its deletion in the Potocki-Shaffer syndrome region at 11p11.2 and its disruption in three patients with balanced translocations. In addition, three patients with de novo truncating mutations in PHF21A were reported recently. Here, we analyze genomic data from seven unrelated individuals with mutations in PHF21A and provide detailed clinical descriptions, further expanding the phenotype associated with PHF21A haploinsufficiency. Methods Diagnostic trio whole exome sequencing, Sanger sequencing, use of GeneMatcher, targeted gene panel sequencing, and MiSeq sequencing techniques were used to identify and confirm variants. RT-qPCR was used to measure the normal expression pattern of PHF21A in multiple human tissues including 13 different brain tissues. Protein-DNA modeling was performed to substantiate the pathogenicity of the missense mutation. Results We have identified seven heterozygous coding mutations, among which six are de novo (not maternal in one). Mutations include four frameshifts, one nonsense mutation in two patients, and one heterozygous missense mutation in the AT Hook domain, predicted to be deleterious and likely to cause loss of PHF21A function. We also found a new C-terminal domain composed of an intrinsically disordered region. This domain is truncated in six patients and thus likely to play an important role in the function of PHF21A, suggesting that haploinsufficiency is the likely underlying mechanism in the phenotype of seven patients. Our results extend the phenotypic spectrum of PHF21A mutations by adding autism spectrum disorder, epilepsy, hypotonia, and neurobehavioral problems. Furthermore, PHF21A is highly expressed in the human fetal brain, which is consistent with the neurodevelopmental phenotype. Conclusion Deleterious nonsense, frameshift, and missense mutations disrupting the AT Hook domain and/or an intrinsically disordered region in PHF21A were found to be associated with autism spectrum disorder, epilepsy, hypotonia, neurobehavioral problems, tapering fingers, clinodactyly, and syndactyly, in addition to intellectual disability and craniofacial anomalies. This suggests that PHF21A is involved in autism spectrum disorder and intellectual disability, and its haploinsufficiency causes a diverse neurological phenotype.
- Published
- 2019
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129. Nightside condensation of iron in an ultrahot giant exoplanet
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Claudio Cumani, João Coelho, Alessandro Sozzetti, David Alves, S. Deiries, Alessio Zanutta, Alexandre Cabral, Andrea Mehner, Luca Pasquini, Paolo Di Marcantonio, Luca Oggioni, Cristina Martins, Nelson J. Nunes, Andrea Modigliani, Antonio Manescau, Olivier Demangeon, Monika Lendl, Christophe Lovis, Matteo Aliverti, Emeline Bolmont, François Bouchy, Jonay I. González Hernández, Gaspare Lo Curto, Bernard Delabre, Heather M. Cegla, V. Baldini, Igor Coretti, Gerardo Avila, Willy Benz, Pedro Santos, Eric Müller, Hugo M. Tabernero, Olaf Iwert, Roberto Cirami, Francesco Pepe, F. Tenegi, Paolo Conconi, Mário J. P. F. G. Monteiro, Marco Landoni, Matteo Genoni, Paolo Spanò, Manuel Abreu, Stéphane Udry, M. Moschetti, Jean-Louis Lizon, Xavier Dumusque, J. Knudstrup, Valentina D'Odorico, Romain Allart, M. Affolter, Núria Casasayas-Barris, Baptiste Lavie, Sérgio F. Sousa, Christopher Broeg, Denis Mégevand, Nuno C. Santos, Marco Riva, Enric Palle, Giorgio Pariani, Edoardo Maria Alberto Redaelli, Vincent Bourrier, Filippo Maria Zerbi, Alex Segovia Milla, Florian Kerber, Damien Ségransan, Rafael Rebolo, I. Hughes, Francesco Borsa, Paolo Santin, Samuel Santana Tschudi, Antonio Gouveia Oliveira, Giuseppina Micela, Pedro Figueira, Charles Maire, Andrea Bianco, Maria Rosa Zapatero Osorio, Danuta Sosnowska, Nathan Hara, Ricardo Génova Santos, David Ehrenreich, Paolo Molaro, Vardan Adibekyan, T. Bandy, Yann Alibert, Jose Luis Rasilla, M. A. Monteiro, Carlos Allende Prieto, L. Genolet, Stefano Cristiani, A. Fragoso, Alejandro Suárez Mascareño, Julia V. Seidel, Ennio Poretti, M. Amate, Hans Dekker, Giorgio Calderone, G. Cupani, Suárez Mascareño, A. [0000-0002-3814-5323], Abreu, M. [0000-0002-0716-9568], Coelho, P. [0000-0002-4339-0550], Monteiro, M. J. [0000-0003-0513-8116], Tabernero, H. [0000-0002-8087-4298], Nunes, N. J. [0000-0002-3837-6914], Cabral, A. [0000-0002-9433-871X], Molaro, P. [0000-0002-0571-4163], Redaelli, E. M. A. [0000-0001-8185-2122], Zapatero Osorio, M. R. [0000-0001-5664-2852], Castro Alves, D. [0000-0001-7026-2514], Seidel, J. V. [0000-0002-7990-9596], Martins, C. J. A. P. [0000-0002-4886-9261], Adibekyan, V. [0000-0002-0601-6199], Zerbi, F. M. [0000-0002-9996-973X], Monteiro, M. [0000-0001-5644-0898], Mehner, A. [0000-0002-9564-3302], Santos, N. [0000-0003-4422-2919], Cegla, H. [0000-0001-8934-7315], Sozzetti, A. [0000-0002-7504-365X], Allart, R. [0000-0002-1199-9759], Landoni, M. [0000-0001-5570-5081], Coretti, I. [0000-0001-9374-3249], FEDER, Portuguese funds through FCT (Fundacao para a Ciencia e a Tecnologia), Spanish Ministry for Science, Innovation and Universities (MICIU), MICIU under the 2013 Ramon y Cajal programme MICIU, Council (ERC) under the European Union's Horizon 2020 research and innovation programme (project FOUR ACES), Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737, João M. P. Coelho. [0000-0002-4339-0550], European Research Council (ERC), Swiss National Science Foundation (SNSF), Fundacao para a Ciencia e a Tecnologia (FCT), Agencia Estatal de Investigación (AEI), Ministerio de Economía y Competitividad (MINECO), ITA, DEU, ESP, CHL, PRT, and CHE
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Earth and Planetary Astrophysics (astro-ph.EP) ,Multidisciplinary ,010504 meteorology & atmospheric sciences ,Terminator (solar) ,Condensation ,FOS: Physical sciences ,Astrophysics ,01 natural sciences ,7. Clean energy ,Exoplanet ,Article ,Starlight ,Astrophysics - Solar and Stellar Astrophysics ,13. Climate action ,Atmospheric chemistry ,0103 physical sciences ,Physics::Space Physics ,Transit (astronomy) ,Astrophysics::Earth and Planetary Astrophysics ,Spectroscopy ,Absorption (electromagnetic radiation) ,010303 astronomy & astrophysics ,Solar and Stellar Astrophysics (astro-ph.SR) ,0105 earth and related environmental sciences ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Ehrenreich, D.et al., Ultrahot giant exoplanets receive thousands of times Earth’s insolation. Their high-temperature atmospheres (greater than 2,000 kelvin) are ideal laboratories for studying extreme planetary climates and chemistry. Daysides are predicted to be cloud-free, dominated by atomic species and much hotter than nightsides. Atoms are expected to recombine into molecules over the nightside, resulting in different day and night chemistries. Although metallic elements and a large temperature contrast have been observed, no chemical gradient has been measured across the surface of such an exoplanet. Different atmospheric chemistry between the day-to-night (‘evening’) and night-to-day (‘morning’) terminators could, however, be revealed as an asymmetric absorption signature during transit. Here we report the detection of an asymmetric atmospheric signature in the ultrahot exoplanet WASP-76b. We spectrally and temporally resolve this signature using a combination of high-dispersion spectroscopy with a large photon-collecting area. The absorption signal, attributed to neutral iron, is blueshifted by −11 ± 0.7 kilometres per second on the trailing limb, which can be explained by a combination of planetary rotation and wind blowing from the hot dayside. In contrast, no signal arises from the nightside close to the morning terminator, showing that atomic iron is not absorbing starlight there. We conclude that iron must therefore condense during its journey across the nightside., With funding from the Spanish government through the "María de Maeztu Unit of Excellence" accreditation (MDM-2017-0737)
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130. Some Topics on Frobenius–Lusztig Kernels, I
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Eric Müller
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Algebra and Number Theory ,restricted specialization coradical filtration ,automorphisms ,Quantum group ,Mathematics::Rings and Algebras ,Rosso's form ,Hopf algebra ,Automorphism ,Quasitriangular Hopf algebra ,Algebra ,Mathematics::Category Theory ,Mathematics::Quantum Algebra ,Frobenius–Lusztig kernels ,Mathematics::Representation Theory ,half quantum groups ,Mathematics - Abstract
An alternative description of the Frobenius–Lusztig kernels and restricted specializations is presented and used to find their coradical filtrations, automorphisms, and imbeddings. Moreover, factor Hopf algebras of the Frobenius–Lusztig kernels are determined.
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131. Virtual reality simulation to enhance advanced trauma life support trainings – a randomized controlled trial
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Tanja Birrenbach, Raphael Stuber, Conrad Eric Müller, Paul-Martin Sutter, Wolf E. Hautz, Aristomenis K. Exadaktylos, Martin Müller, Rafael Wespi, and Thomas Christian Sauter
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ATLS ,Virtual reality ,Trauma management ,Medical education ,Simulation ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background Advanced Trauma Life Support (ATLS) is the gold standard of initial assessment of trauma patients and therefore a widely used training program for medical professionals. Practical application of the knowledge taught can be challenging for medical students and inexperienced clinicians. Simulation-based training, including virtual reality (VR), has proven to be a valuable adjunct to real-world experiences in trauma education. Previous studies have demonstrated the effectiveness of VR simulations for surgical and technical skills training. However, there is limited evidence on VR simulation training specifically for trauma education, particularly within the ATLS curriculum. The purpose of this pilot study is to evaluate the feasibility, effectiveness, and acceptance of using a fully immersive VR trauma simulation to prepare medical students for the ATLS course. Methods This was a prospective randomised controlled pilot study on a convenience sample of advanced medical students (n = 56; intervention group with adjunct training using a commercially available semi-automated trauma VR simulation, n = 28, vs control group, n = 28) taking part in the ATLS course of the Military Physician Officer School. Feasibility was assessed by evaluating factors related to technical factors of the VR training (e.g. rate of interruptions and premature termination). Objective and subjective effectiveness was assessed using confidence ratings at four pre-specified points in the curriculum, validated surveys, clinical scenario scores, multiple choice knowledge tests, and ATLS final clinical scenario and course pass rates. Acceptance was measured using validated instruments to assess variables of media use (Technology acceptance, usability, presence and immersion, workload, and user satisfaction). Results The feasibility assessment demonstrated that only one premature termination occurred and that all remaining participants in the intervention group correctly stabilised the patient. No significant differences between the two groups in terms of objective effectiveness were observed (p = 0.832 and p = 0.237 for the pretest and final knowledge test, respectively; p = 0.485 for the pass rates for the final clinical scenario on the first attempt; all participants passed the ATLS course). In terms of subjective effectiveness, the authors found significantly improved confidence post-VR intervention (p
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- 2024
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132. MM-Locate-News: Multimodal Focus Location Estimation in News
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Golsa Tahmasebzadeh, Eric Müller-Budack, Sherzod Hakimov, and Ralph Ewerth
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133. Inference with Artificial Neural Networks on Analog Neuromorphic Hardware
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Eric Müller, Philipp Spilger, Andreas Grübl, Mitja Kleider, Korbinian Schreiber, Sebastian Billaudelle, Oliver Breitwieser, Christian Mauch, Joscha Ilmberger, Johannes Weis, Yannik Stradmann, Vitali Karasenko, Johannes Schemmel, and Arne Emmel
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Spiking neural network ,Artificial neural network ,business.industry ,Computer science ,020208 electrical & electronic engineering ,02 engineering and technology ,Convolutional neural network ,03 medical and health sciences ,0302 clinical medicine ,Application-specific integrated circuit ,Neuromorphic engineering ,0202 electrical engineering, electronic engineering, information engineering ,Multiplication ,Noise (video) ,business ,030217 neurology & neurosurgery ,Computer hardware ,MNIST database - Abstract
The neuromorphic BrainScaleS-2 ASIC comprises mixed-signal neurons and synapse circuits as well as two versatile digital microprocessors. Primarily designed to emulate spiking neural networks, the system can also operate in a vector-matrix multiplication and accumulation mode for artificial neural networks. Analog multiplication is carried out in the synapse circuits, while the results are accumulated on the neurons’ membrane capacitors. Designed as an analog, in-memory computing device, it promises high energy efficiency. Fixed-pattern noise and trial-to-trial variations, however, require the implemented networks to cope with a certain level of perturbations. Further limitations are imposed by the digital resolution of the input values (5 bit), matrix weights (6 bit) and resulting neuron activations (8 bit). In this paper, we discuss BrainScaleS-2 as an analog inference accelerator and present calibration as well as optimization strategies, highlighting the advantages of training with hardware in the loop. Among other benchmarks, we classify the MNIST handwritten digits dataset using a two-dimensional convolution and two dense layers. We reach 98.0% test accuracy, closely matching the performance of the same network evaluated in software.
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134. A Feature Analysis for Multimodal News Retrieval
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Eric Müller-Budack
135. On the Role of Images for Analyzing Claims in Social Media
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Eric Müller-Budack
136. MSH2/BRCA1 expression as a DNA-repair signature predicting survival in early-stage lung cancer patients from the IFCT-0002 Phase 3 Trial.
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Levallet G, Dubois F, Fouret P, Antoine M, Brosseau S, Bergot E, Beau-Faller M, Gounant V, Brambilla E, Debieuvre D, Molinier O, Galateau-Sallé F, Mazieres J, Quoix E, Pujol JL, Moro-Sibilot D, Langlais A, Morin F, Westeel V, and Zalcman G
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- Adult, Aged, Carcinoma, Non-Small-Cell Lung metabolism, DNA Methylation, DNA Modification Methylases genetics, DNA Repair Enzymes genetics, Drug Therapy, Female, Gene Expression Regulation, Neoplastic, Humans, Ku Autoantigen metabolism, Lung Neoplasms metabolism, Male, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, Prognosis, Promoter Regions, Genetic, Prospective Studies, Survival Analysis, Tumor Suppressor Proteins genetics, BRCA1 Protein metabolism, Carcinoma, Non-Small-Cell Lung drug therapy, DNA Repair, Lung Neoplasms drug therapy, MutS Homolog 2 Protein metabolism
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Introduction: DNA repair is a double-edged sword in lung carcinogenesis. When defective, it promotes genetic instability and accumulated genetic alterations. Conversely these defects could sensitize cancer cells to therapeutic agents inducing DNA breaks., Methods: We used immunohistochemistry (IHC) to assess MSH2, XRCC5, and BRCA1 expression in 443 post-chemotherapy specimens from patients randomized in a Phase 3 trial, comparing two neoadjuvant regimens in 528 Stage I-II non-small cell lung cancer (NSCLC) patients (IFCT-0002). O6MGMT promoter gene methylation was analyzed in a subset of 208 patients of the same trial with available snap-frozen specimens., Results: Median follow-up was from 90 months onwards. Only high BRCA1 (n = 221, hazard ratio [HR] = 1.58, 95% confidence interval [CI] [1.07-2.34], p = 0.02) and low MSH2 expression (n = 356, HR = 1.52, 95% CI [1.11-2.08], p = 0.008) significantly predicted better overall survival (OS) in univariate and multivariate analysis. A bootstrap re-sampling strategy distinguished three patient groups at high (n = 55, low BRCA1 and high MSH2, median OS >96 months, HR = 2.5, 95% CI [1.45-4.33], p = 0.001), intermediate (n = 82, median OS = 73.4 p = 0.0596), and low (high BRCA1 and low MSH2, n = 67, median OS = ND, HR = 0.51, 95% CI [0.31-0.83], p = 0.006) risk of death., Interpretation: DNA repair protein expression assessment identified three different groups of risk of death in early-stage lung cancer patients, according to their tumor MSH2 and BRCA1 expression levels. These results deserve prospective evaluation of MSH2/BRCA1 theranostic value in lung cancer patients treated with combinations of DNA-damaging chemotherapy and drugs targeting DNA repair, such as Poly(ADP-ribose) polymerase (PARP) inhibitors.
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- 2017
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