101. The interferon response to intracellular DNA: Why so many receptors?
- Author
-
Leonie Unterholzner
- Subjects
Immunology ,Three prime repair exonuclease 1 ,Gene Expression ,Autoimmunity ,Receptors, Cell Surface ,Biology ,AIM2 ,Animals ,Humans ,Immunology and Allergy ,education ,Inflammation ,Genetics ,education.field_of_study ,Toll-like receptor ,Innate immune system ,Cyclic GMP-AMP synthase ,Pathogen-associated molecular pattern ,Intracellular parasite ,Pattern recognition receptor ,DNA ,Hematology ,Immunity, Innate ,Cell biology ,Virus Diseases ,Interferon Type I - Abstract
The detection of intracellular DNA has emerged to be a key event in the innate immune response to viruses and intracellular bacteria, and during conditions of sterile inflammation and autoimmunity. One of the consequences of the detection of DNA as a 'stranger' and a 'danger' signal is the production of type I interferons and pro-inflammatory cytokines. Much work has been dedicated to the elucidation of the signalling cascades that activate this DNA-induced gene expression programme. However, while many proteins have been proposed to act as sensors for intracellular DNA in recent years, none has been met with universal acceptance, and a theory linking all the recent observations is, as yet, lacking. This review presents the evidence for the various interferon-inducing DNA receptors proposed to date, and examines the hypotheses that might explain why so many different receptors appear to be involved in the innate immune recognition of intracellular DNA.
- Published
- 2013