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Interferons and inflammasomes: Cooperation and counterregulation in disease
- Source :
- The journal of allergy and clinical immunology 138(1), 37-46 (2016). doi:10.1016/j.jaci.2016.05.010
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- Interferons and the IL-1 family of cytokines have important roles in host defense against invading viruses and bacteria. Inflammasomes, multimeric cytosolic sensors of infection, are required for IL-1β and IL-18 processing and release. Interferons, IL-1β, and IL-18 are also implicated in autoimmune disease and chronic inflammation. Although independent but complementary pathways induce these cytokine subsets during infection, in some circumstances the cross-talk between these key inflammatory mediators is a particular requirement for effective host defense. In this review we will summarize recent discoveries concerning the potentiation of inflammasome responses by type I interferons, particularly in patients with gram-negative bacterial infections, and reflect on the molecular mechanisms of IFN-β's immunosuppressive effects through modulation of inflammasome and IL-1β signaling in patients with tuberculosis and multiple sclerosis.
- Subjects :
- 0301 basic medicine
Inflammasomes
medicine.medical_treatment
metabolism [NLR Family, Pyrin Domain-Containing 3 Protein]
Immunology
Interleukin-1beta
Caspase-11
Biology
Autoimmune Diseases
metabolism [Interferons]
03 medical and health sciences
AIM2
metabolism [Autoimmune Diseases]
immunology [Host-Pathogen Interactions]
0302 clinical medicine
metabolism [Interleukin-1beta]
NLR Family, Pyrin Domain-Containing 3 Protein
medicine
Immunology and Allergy
Animals
metabolism [Caspases]
Humans
ddc:610
Inflammation
Toll-like receptor
metabolism [Inflammation]
Cyclic GMP-AMP synthase
etiology [Autoimmune Diseases]
Pyroptosis
Interleukin-18
Inflammasome
030104 developmental biology
Cytokine
etiology [Inflammation]
Caspases
Host-Pathogen Interactions
metabolism [Interleukin-18]
Interferons
metabolism [Inflammasomes]
030215 immunology
medicine.drug
Interferon regulatory factors
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- The journal of allergy and clinical immunology 138(1), 37-46 (2016). doi:10.1016/j.jaci.2016.05.010
- Accession number :
- edsair.doi.dedup.....780ca24c70d3999bd018e44387cea8e7