Search

Press cards do not make reporters. Reporters must master the skills of investigating, understanding information and communicating information to his readers. Press cards to serve a limited function, such as allowing journalists access to a briefing area or the scene of a news story. Despite the limited usefulness of press cards, they are still imbued with a sense of importance and credibility.

In the budding yeast Saccharomyces cerevisiae, the G1-specific cyclin-dependent kinases (Cdks) Cln1,2-Cdc28 and Pcl1,2-Pho85 are essential for ensuring that DNA replication and cell division are properly linked to cell polarity and bud morphogenesis. However, the redundancy of Cdks and cyclins means that identification of relevant Cdk substrates remains a significant challenge. We used array-based genetic screens (synthetic genetic array or SGA analysis) to dissect redundant pathways associated with G1 cyclins and identified Bni4 as a substrate of the Pcl1- and Pcl2-Pho85 kinases. BNI4 encodes an adaptor protein that targets several proteins to the bud neck. Deletion of BNI4 results in severe growth defects in the absence of the Cdc28 cyclins Cln1 and Cln2, and overexpression of BNI4 is toxic in yeast cells lacking the Pho85 cyclins Pcl1 and Pcl2. Phosphorylation of Bni4 by Pcl-Pho85 is necessary for its localization to the bud neck, and the bud neck structure can be disrupted by overexpressing BNI4 in pcl1Δpcl2Δ mutant cells. Our data suggest that misregulated Bni4 may bind in an uncontrolled manner to an essential component that resides at the bud neck, causing catastrophic morphogenesis defects.

During those years, I watched Cyrix, Intel, and the more viable AMD duke it out over processors, but always stuck with my flagship, if you will: Intel. AMD has always been as good if not better than Intel, but for me, it took this combination of price, options, and even the Ryzen format being similarly named to what I'd been accustomed to in Intel, 3/5/7, to finally change my mind. I have read several of your issues and I've found that none of the budget builds contain anything cheaper than a Ryzen 5 2600 - for example, a Ryzen 5 1500X or a Ryzen 3 1300X. [Extracted from the article]

Several letters to the editor are presented including a suggestion to mention the Roaring '20s by Scott Brannon, appreciation for the articles that explore the subject of uncrowned heroes of their Society by George Shields, and comments on an article that mentioned the Easternaires by Tom Dames.

Focuses on the career of Graham Dawe, rugby football player of Plymouth Albion. Contribution of Dawe to the success of the team in several tournaments; Career achievements on Albion; Analysis on the strength and weaknesses of the team.