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The focal nature of atherosclerotic lesions suggests an important role of local hemodynamic environment. Recent studies have demonstrated significant roles of Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in mediating mechanotransduction and vascular homeostasis. The objective of this study is to investigate the functional role of YAP/TAZ in the flow regulation of atheroprone endothelial phenotypes and the consequential development of atherosclerotic lesions. We found that exposure of cultured endothelial cells (ECs) to the atheroprone disturbed flow resulted in YAP/TAZ activation and translocation into EC nucleus to up-regulate the target genes, including cysteine-rich angiogenic inducer 61 (CYR61), connective tissue growth factor (CTGF), and ankyrin repeat domain 1 (ANKRD1). In contrast, the athero-protective laminar flow suppressed YAP/TAZ activities. En face analysis of mouse arteries demonstrated an increased nuclear localization of YAP/TAZ and elevated levels of the target genes in the endothelium in atheroprone areas compared with athero-protective areas. YAP/TAZ knockdown significantly attenuated the disturbed flow induction of EC proliferative and proinflammatory phenotypes, whereas overexpression of constitutively active YAP was sufficient to promote EC proliferation and inflammation. In addition, treatment with statin, an antiatherosclerotic drug, inhibited YAP/TAZ activities to diminish the disturbed flow-induced proliferation and inflammation. In vivo blockade of YAP/TAZ translation by morpholino oligos significantly reduced endothelial inflammation and the size of atherosclerotic lesions. Our results demonstrate a critical role of the activation of YAP/TAZ by disturbed flow in promoting atheroprone phenotypes and atherosclerotic lesion development. Therefore, inhibition of YAP/TAZ activation is a promising athero-protective therapeutic strategy.

BackgroundLong-term exposure to fine particulate matter less than 2.5 μm in diameter (PM2.5) and traffic-related air pollutant concentrations are associated with cardiovascular risk. The disease process underlying these associations remains uncertain. We aim to assess association between long-term exposure to ambient air pollution and progression of coronary artery calcium and common carotid artery intima-media thickness.MethodsIn this prospective 10-year cohort study, we repeatedly measured coronary artery calcium by CT in 6795 participants aged 45-84 years enrolled in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) in six metropolitan areas in the USA. Repeated scans were done for nearly all participants between 2002 and 2005, for a subset of participants between 2005 and 2007, and for half of all participants between 2010 and 2012. Common carotid artery intima-media thickness was measured by ultrasound in all participants at baseline and in 2010-12 for 3459 participants. Residence-specific spatio-temporal pollution concentration models, incorporating community-specific measurements, agency monitoring data, and geographical predictors, estimated concentrations of PM2.5 and nitrogen oxides (NOX) between 1999 and 2012. The primary aim was to examine the association between both progression of coronary artery calcium and mean carotid artery intima-media thickness and long-term exposure to ambient air pollutant concentrations (PM2.5, NOX, and black carbon) between examinations and within the six metropolitan areas, adjusting for baseline age, sex, ethnicity, socioeconomic characteristics, cardiovascular risk factors, site, and CT scanner technology.FindingsIn this population, coronary calcium increased on average by 24 Agatston units per year (SD 58), and intima-media thickness by 12 μm per year (10), before adjusting for risk factors or air pollutant exposures. Participant-specific pollutant concentrations averaged over the years 2000-10 ranged from 9.2-22.6 μg PM2.5/m(3) and 7.2-139.2 parts per billion (ppb) NOX. For each 5 μg PM2.5/m(3) increase, coronary calcium progressed by 4.1 Agatston units per year (95% CI 1.4-6.8) and for each 40 ppb NOX coronary calcium progressed by 4.8 Agatston units per year (0.9-8.7). Pollutant exposures were not associated with intima-media thickness change. The estimate for the effect of a 5 μg/m(3) higher long-term exposure to PM2.5 in intima-media thickness was -0.9 μm per year (95% CI -3.0 to 1.3). For 40 ppb higher NOX, the estimate was 0.2 μm per year (-1.9 to 2.4).InterpretationIncreased concentrations of PM2.5 and traffic-related air pollution within metropolitan areas, in ranges commonly encountered worldwide, are associated with progression in coronary calcification, consistent with acceleration of atherosclerosis. This study supports the case for global efforts of pollution reduction in prevention of cardiovascular diseases.FundingUS Environmental Protection Agency and US National Institutes of Health.

BackgroundAge and human immunodeficiency virus (HIV) treatment may affect the association of HIV infection with atherosclerosis.MethodsWe used identical carotid artery B-mode ultrasonographic methods in 5 cohorts participating in the National Heart, Lung, and Blood Institute HIV-CVD Collaborative to measure intima-media thickness of the right far wall of the common carotid artery (CCA-IMT) and carotid artery bifurcation (BIF-IMT) between 2010 and 2013. Participants aged 6-75 years were either HIV infected or uninfected. Linear regression assessed associations of CCA-IMT and BIF-IMT with HIV infection and cardiovascular disease risk factors, within age and HIV treatment groups. Adjustment variables included sex, race/ethnicity, smoking, height, weight, and use of antihypertensive and lipid-lowering drugs.ResultsWe studied 867 HIV-infected and 338 HIV-uninfected male and 696 HIV-infected and 246 HIV-uninfected female participants. Among both middle-aged (30-49 years) and older adults (50-75 years), HIV-infected participants had CCA-IMT and BIF-IMT values that were similar to or lower than those in HIV-uninfected participants. In contrast, among those aged 6-29 years, HIV infection was associated with higher CCA-IMT and BIF-IMT values. Among HIV-infected participants, associations of higher systolic blood pressure and lower high-density lipoprotein cholesterol with Carotid artery intima-media thickness strengthened with age.ConclusionsThe effects of HIV on carotid artery structure may differ across the lifespan, with traditional determinants of cardiovascular disease burden playing a larger role and HIV playing a lesser role in older adults than in young adults and children.

The "bovine" aortic arch is an anatomic variant consisting in a common origin of the innominate and left carotid artery (CILCA), associated with a greater risk of thoracic aortic diseases (aneurysms and dissections), stroke, and complications after endovascular procedures. CILCA can be detected by visual assessment of computed tomography (CT) chest scans, but it is rarely reported. We developed a deep learning (DL) segmentation-plus-classification system to automatically detect CILCA based on 302 CT studies acquired at 2 centers. One model (3D U-Net) was trained from scratch (supervised by manual segmentation), validated, and tested for the automatic segmentation of the aortic arch and supra-aortic vessels. Three DL architectures (ResNet50, DenseNet-201, and SqueezeNet), pre-trained over millions of common images, were trained, validated, and tested for the automatic classification of CILCA versus non-CILCA, supervised by radiologist's classification. The 3D U-Net-plus-DenseNet-201 was found to be the best system (Dice index 0.912); its classification performance obtained from internal, independent testing on 126 patients gave a receiver operating characteristic area under the curve of 87.0%, sensitivity 66.7%, specificity 90.5%, positive predictive value 87.5%, negative predictive value 73.1%, positive likelihood ratio 7.0, and negative likelihood ratio 0.4. In conclusion, a combined DL system applied to chest CT scans was developed and proven to be an effective tool to detect individuals with "bovine" aortic arch with a low rate of false-positive findings. [ABSTRACT FROM AUTHOR]

This essay aims to establish a possible relationship of institutional and organizational learning to the problems caused by Covid-19 and it's health emergency, from the Brazilian experience of creation of it's "brand-new" federal universities. In these institutions, social participation and engagement prevailed so that they could be formatted based on the logic of regionalized education, as a potentializer of territorial development processes. This theoretical-reflexive relationship is built from the considerations of Tenório (2020) and Giannella (2020) on the social effects of Covid-19, with regard to the increased social area, regarding to a new and necessary democracy, and the redefinition of the Common in a post-pandemic world, respectively. In the end, this essay proposes that the experience of the brand-new federal universities can be an important instrument for multiple answers to the questions raised by this contribution. [ABSTRACT FROM AUTHOR]

The article explores the plurivocity of Marx's text taking as reference two key ideas of his thought: the community and the common. The idea of community represents the supposedly natural and true sociality and at the same time holds a logical and normative privilege over capitalist society, while the idea of the common, usually identified with the figure of the social bond, escapes metaphysical binarisms insofar as it is the condition of possibility of all forms of collective life. Parallel to the analysis of the counterpoint between the community and the common, the article aims to investigate some general aspects of the relationship between history and ontology in Marx's work. [ABSTRACT FROM AUTHOR]

In this literature review work, there is a discussion on the constitution of the common in public school, understanding it as a field of singularities/multiplicities, of freedom of speech, which craves for a participatory democracy. With this review, the understanding of the communal is articulated to the accomplishment of evangelical groups, with their moral values (or merits) and practices, based on a discrimination between the religious institutionality and the spiritual church. The conclusion is that the appreciation of collective spaces is a fundamental alternative of/for freedom of expression, as well as of confronting the religious extremisms that present themselves. [ABSTRACT FROM AUTHOR]

The phrase “on care of our common home” is the subtitle of the encyclical Laudato si’. The notion of “care” can be understood as the preservation of the creative capacities found in the various components of creation. The notion of the “common home” is not clearly defined, but can be understood in terms of a salvation promised to all creatures, a salvation that consists in universal communion. This also leads us to take the Earth seriously and to ensure that the diversity of its components contributes to the construction of the “common home”. The theology of incarnation emphasises the plurality of expressions of God’s presence in the created world. This plurality is at the service of the communion of all. [ABSTRACT FROM AUTHOR]

Copyright of Interface - Comunicação, Saúde, Educação is the property of Fundacao UNI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Via Inveniendi et Iudicandi is the property of Universidad Santo Tomas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective/Introduction: Near-infrared spectroscopy (NIRS) is a noninvasive technique to detect cerebral ischemia by monitoring changes in regional cerebral oxygenation (rSO2) in the frontal lobes. However, there are no studies showing the changes in NIRS values in response to hemodynamic variations during stages of carotid endarterectomy (CEA) procedure and clinical implications of these changes. The aim of this study was to determine if hemodynamic changes affect NIRS values during carotid endarterectomy and if our results may help to provide strategies for hemodynamic management in these patients. Methods: A total of 50 consecutive patients undergoing CEA were prospectively included in the study. NIRS was measured at first minute after clamping of carotid artery, and then systolic blood pressure was increased above 150 mmHg. NIRS values from both hemispheres were recorded simultaneously at certain time points and were analyzed to evaluate the changes at different stages of operation and to assess correlations with hemodynamic parameters. Results: NIRS values on the right and left sides were correlated with systolic (right P<0.001, R2:0.24; left P=0.02, R2:0.10) diastolic (right P<0.001, R2:0.36; left P=0.001, R2:0.18) and mean (right P<0.001, R2:0.33; left P=0.003, R2:0.17) blood pressures when the patient was under general anaesthesia. NIRS values were significantly lower than preincision values just after clamping of carotid artery in both hemispheres (P=0.005 for the right and P<0.001 for the left side). Conclusion: NIRS values measured in our study show that there is a correlation between hemodynamic changes and cerebral oxygenation. This effect is especially pronounced while the patient is asleep and intubated, which implies the importance of close monitoring of patients with carotid disease during any surgery requiring general anaesthesia. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Taibah University Arts & Humanities is the property of Association of Arab Universities and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We propose a geography that pluralizes the sites, practices and politics of authority. We defend an approach that tracks less perceptible forms of authority emerging through everyday micropolitics and experimental practices. In contrast to dominant definitions of authority as institutionalized legitimate power, we define authority as a relation of guidance emerging from recognition of inequalities in access to truth, experience or objectivity. Analysing four intersecting areas of authority (algorithmic, experiential, expert and participatory authority), we propose analyses grounded in political aesthetics that trace authority's affective force, and its role in disclosing and contesting the common. [ABSTRACT FROM AUTHOR]

Commoning embodies the product of social contracts and behaviors between groups of individuals. In the case of social housing and the establishment of physical domains for life, commoning is an intersection of these contracts and the restrictions and policies that prohibit and allow them to occur within municipalities. Via a platform-based project entitled Public Parts (2020), this article will also present positions on the reification of the common through a set of design methodologies and implementations of automation. This platform seeks to subvert typical platform models to decrease ownership, increase access, and produce a new form of communal autonomous life amongst individuals that constitute the rapidly expanding freelance, work from home, and gig economies. Furthermore, this text investigates the consequences of merging domestic space with artificial intelligence by implementing machine learning to reconfigure spaces and program. The problems that arise from the deployment of machine learning algorithms involve issues of collection, usage, and ownership of data. Through the physical design of space, and a central AI which manages the platform and the automated management of space, the core objective of Public Parts is to reify the common through architecture and collectively owned data. [ABSTRACT FROM AUTHOR]

Editorial for CPCL Vol 2, no 2 (2019) The New Spaces of the Common: Spatial and Political Models of "Making"

Objective: The objective of this study is to establish a nursing standard of integrated traditional Chinese and Western medicine for patients with COVID-19 (mild and common) in Beijing, to provide reference for clinical nursing of patients with COVID-19 (mild and common). Methods: Through online communication meeting with nurses who are in the frontline of anti-epidemic, clinical investigation, literature research, and expert demonstration meeting are carried out to prepare the draft of the standard, and the Delphi method is applied to determine the standard of integrated traditional Chinese and Western medicine care for patients with COVID-19 (mild and common) in Beijing. Results: The nursing standard of integrated traditional Chinese and Western medicine for patients with COVID-19 (mild and common) was established, which included 5 first-level indicators, 14 second-level indicators and 60 third-level indicators. After two rounds of Delphi method, the positive coefficients of experts were 96% and 83%, the authoritative coefficients of experts were 0.89 and 0.91, and the Kendall's coefficient of concordance (W) of experts were 0.12, 0.09, 0.10, 0.13 (P < 0.05) and 0.44, 0.43, 0.37, 0.39 (P < 0.05). Conclusion: The standard of integrated traditional Chinese and Western medicine nursing for patients with COVID-19 (mild and common) in Beijing constructed by the Delphi method is scientific and practical, which provides a reference for clinical application of integrated traditional Chinese and Western medicine nursing to fight against COVID-19 infection.

Inflammatory myofibroblastic tumour is a rare entity of indeterminate biological potential with a reduced tendency for recurrence and metastasis. Although it can arise from multiple organs, the bile duct is a very rare site of origin. We report the case of a 75-year-old asymptomatic male with elevated gamma-glutamyl transferase [1575 U/L (12 - 64 U/L)] and alkaline phosphatase [271 U/L (40 - 150 U/L)]. Computed tomography showed a 17 mm hypervascular lesion in the confluence of the right and left hepatic ducts, with bile duct ectasia and right liver lobe atrophy. The patient was initially managed as having a Klatskin tumour and underwent right hepatectomy. Histology showed a spindle cell proliferation with an inflammatory infiltrate of lymphocytes, plasma cells and collagen-rich stroma, consistent with an inflammatory myofibroblastic tumour. He was discharged 30 days after admission, and nine months later remains asymptomatic. His liver function tests have normalized and follow-up tests are unremarkable.

Abstract This narrative is the result of the round of talks “Chico Mendes Vive”, held during the III Latin American Congress of Political Ecology. It is a living experience of four Amazonian women, Angela Mendes, Claudelice Santos, Edel Moraes and Sônia Guajajara, whose speeches emerge from the experience of indigenous, black, cabocla, agro-extractivist women, who make of their lives a struggle in defense of Mother Earth and of the “common good”, which aggregates, welcomes and feeds all the other forms of being in the universe. This narrative expresses the continuity of the re-existence of native and indigenous peoples, the reconnection of the peoples of the forest, water and countryside, through the legacy left by Chico Mendes, a son of the Amazon, who was assassinated for defending and fighting for life.

Structural variations (SV) are large (>50 base pairs) genomic rearrangements comprising deletions, duplications, insertions, inversions, and translocations. Studying SVs is important because they play active and critical roles in regulating gene expression, determining disease predispositions, and identifying population-specific differences among individuals of diverse ancestries. However, SV discoveries in the Indian population using whole-genome sequencing (WGS) have been limited. In this study, using short-read WGS having an average 42X depth of coverage, we identify and characterize 36,210 SVs from 529 individuals enrolled in population-based cohorts in India. These SVs include 24,574 deletions, 2,913 duplications, 8,710 insertions, and 13 inversions; 1.26% (456 out of 36,210) of the identified SVs can potentially impact the coding regions of genes. Furthermore, 56 of these SVs are highly intolerant to loss-of-function changes to the mapped genes, and five SVs impacting ADAMTS17, CCDC40, and RHCE are common in our study individuals. Seven rare SVs significantly impact dosage sensitivity of genes known to be associated with various clinical phenotypes. Most of the SVs in our study are rare and heterozygous. This fine-scale SV discovery in the underrepresented Indian population provides valuable insights that extend beyond Eurocentric human genetic studies., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Multiblock analysis holds different approaches leading to separate notions of "common" and "distinct." In this article, we extend this analysis to the domain of distance matrices where configurations are analyzed via relative distances. We have focused on three key aspects: (1) the transition from distance to configurations, (2) managing a tradeoff between explaining variance and ensuring similarity between subspaces, (3) "shared" common parts or associated with each block. A selection of methods was analyzed and subsequently applied to examples. [ABSTRACT FROM AUTHOR]

Acute type A aortic dissection is a surgical emergency and management of such pathology can be complex with poor outcomes when there is organ malperfusion. Carotid artery involvement is present in 30% of patients diagnosed with acute type A aortic dissection, and given its emergency and complex nature, there is much controversy regarding the approach, extent of treatment, and timing of the intervention. It is clear that the occurrence of cerebral malperfusion adds an extra layer of complexity to the decision-making framework for treatment. Standardization and validation of the optimal management approach is required, and this should ideally be addressed with large-scale studies. Nonetheless, current literature supports the need for rapid recognition and diagnosis of acute type A aortic dissection with cerebral malperfusion, immediate and extensive surgical repair, and the appropriate use of cerebral perfusion techniques. This paper aims to discuss the current evidence regarding the impact of carotid artery involvement in both the management and outcomes of acute type A aortic dissection. [ABSTRACT FROM AUTHOR]

Background and purposeThe relationship between carotid artery intima-media thickness (IMT) and cognitive function in midlife remains relatively unexplored. We examined the association between IMT and cognitive function in a middle-aged epidemiological cohort of 2618 stroke-free participants.MethodsAt the year 20 visit (our study baseline), participants from the Coronary Artery Risk Development in Young Adults study had IMT measured by ultrasound at the common carotid artery. Five years later, participants completed a cognitive battery consisting of the Rey Auditory-Verbal Learning Test of verbal memory, the Digit Symbol Substitution Test of processing speed, and the Stroop test of executive function. We transformed cognitive scores into standardized z scores, with negative values indicating worse performance.ResultsMean age at baseline was 45.3 years (SD, 3.6). Greater IMT (per 1 SD difference of 0.12 mm) was significantly associated with worse performance on all cognitive tests (z scores) in unadjusted linear regression models (verbal memory, -0.16; 95% confidence interval [CI], -0.20 to -0.13; processing speed, -0.23; 95% CI, -0.27 to -0.19; and executive function, -0.17; 95% CI, -0.20 to -0.13). In models adjusted for sociodemographics and vascular risk factors that lie earlier in the causal pathway, greater IMT remained negatively associated with processing speed (-0.06; 95% CI, -0.09 to -0.02; P, 0.003) and borderline associated with executive function (-0.03; 95% CI, -0.07 to 0.00; P, 0.07) but not with verbal memory.ConclusionsWe observed an association between greater IMT and worse processing speed-a key component of cognitive functioning-at middle age above and beyond traditional vascular risk factors. Efforts targeted at preventing early stages of atherosclerosis may modify the course of cognitive aging.

PurposeTo develop and evaluate a technique for accelerating phase contrast MRI (PC-MRI) acquisitions without significant compromise in flow quantification accuracy.MethodsPC-MRI is commonly acquired using interleaved flow-compensated (FC) and flow-encoded (FE) echoes. We hypothesized that FC data, which represent background phase, do not change significantly over time. Therefore, we proposed to undersample the FC data and use an FC view sharing (FCVS) approach to synthesize a composite FC frame for each corresponding FE frame. FCVS was evaluated in a flow phantom and healthy volunteers and compared with a standard FC/FE PC-MRI.ResultsThe FCVS sequence resulted in an error of 0.0% for forward flow and 2.0% for reverse flow volume when compared with FC/FE PC-MRI in a flow phantom. Measurements in the common carotid arteries showed that the FCVS method had -1.16 cm/s bias for maximum peak velocity and -0.019 mL bias in total flow, when compared with FC/FE with the same temporal resolution, but double the total acquisition time. These results represent ≤1.3% bias error in velocity and volumetric flow quantification.ConclusionFCVS can accelerate PC-MRI acquisitions while maintaining flow and velocity measurement accuracy when there is limited temporal variation in the FC data.

The understanding of the pathophysiology of brain arteriovenous malformations and arteriovenous fistulas has improved thanks to animal models. A rat model creating an artificial fistula between the common carotid artery (CCA) and the external jugular vein (EJV) has been widely described and proved technically feasible. This construct provokes a consistent cerebral venous hypertension (CVH), and therefore has helped studying the contribution of venous hypertension to formation, clinical symptoms, and prognosis of brain AVMs and dural AVFs. Equivalent mice models have been only scarcely described and have shown trouble with stenosis of the fistula. An established murine model would allow the study of not only pathophysiology but also potential genetic therapies for these cerebrovascular diseases. We present a model of arteriovenous fistula that produces a durable intracranial venous hypertension in the mouse. Microsurgical anastomosis of the murine CCA and EJV can be difficult due to diminutive anatomy and frequently result in a non-patent fistula. In this step-by-step protocol we address all the important challenges encountered during this procedure. Avoiding excessive retraction of the vein during the exposure, using 11-0 sutures instead of 10-0, and making a carefully planned end-to-side anastomosis are some of the critical steps. Although this method requires advanced microsurgical skills and a longer learning curve that the equivalent in the rat, it can be consistently developed. This novel model has been designed to integrate transgenic mouse techniques with a previously well-established experimental system that has proved useful to study brain AVMs and dural AVFs. By opening the possibility of using transgenic mice, a broader spectrum of valid models can be achieved and genetic treatments can also be tested. The experimental construct could also be further adapted to the study of other cerebrovascular diseases related with venous hypertension such as migraine, transient global amnesia, transient monocular blindness, etc.

Monsieur M, 1968 (France, 2011), directed by Laurent Cibien and Isabelle Berteletti, is a documentary that originated from an agenda, dated 1968, found in a house after the death of its owner. Day after day, M, 41, an old boy living with his parents, an office worker at the National Geographical Institute, describes and recounts without passion the meagre events of his life, in a period when everything seems to be out of whack. Thus, the daily functionalism, lived by the strange diarist, transforms into a filmic daydream. But how does the audiovisual mediation create the poetry of daily life capable of making people think about the expression of history on screen? The ordinary daily life appears first of all essential. In addition, history is captured through the psychogeography of everyday life. Finally, the sound editing and the use of videography lead to affirm the disturbing strangeness of the story captured in M’s eye and the modalities of the resistance to May 68.

This paper discusses the low power of traditional care offers for so-called complex users in the health sector. It aims to show, from the narratives of two guiding-users, that professionals, services, and policies disregard the multiple singularities involved in the care and attempt to overlap their knowledge in asymmetrical relationships. They are often put at stake in their ability to generate interesting and more life-producing offers. In this sense, this work built on two qualitative, cartographic studies that aimed to reflect, based on two guiding-users, promoting considerations on how contact with the field/territory and the meeting with these two women (guiding-users) deterritorialized concepts and affected researchers and research. The results indicate that cartography allows the production of the common, understood as a way of operating health work. Here, one seeks to consider each subject's unique individual power as a fundamental issue for the production of care. The disease leaves the scenario as a guide, vulnerability as fragility or impotence, to make way for the "defense of a life worth living" as a guide. Possible lives that users generate, whether or not they are in the streets and a vulnerable condition. [ABSTRACT FROM AUTHOR]

Fungal infections of the skin continue to place a burden on healthcare and are a significant issue globally in terms of their cost and impact on resources. Some are more difficult to treat than others and there is a wide variation in duration of treatment, depending on the site and severity. Many fungal infections share similarities in appearance with other skin conditions, which can sometimes make diagnosis difficult. This article details some of the most common conditions and aims to give nurses and non-medical prescribers an overview of evidence-based treatment and management as well as to increase confidence when managing some of these troublesome diseases. [ABSTRACT FROM AUTHOR]

In rural areas of Colombia, the complex dynamics associated with the armed conflict negatively impacted social ties and relationships, community organizing practices and processes, traditions as well as collective trajectories. The Colombian State has dealt with these impacts through collective reparation; namely, a set of strategies aimed at reconstructing the collective meaning of communities, organizations and groups that have faced the systematic violation of their rights. Given its (collective) nature, reparation makes possible the generation of spaces and forms of social cooperation aimed at the symbolic and material reproduction of life, that is, of processes of production of the common. We explore the collective reparation process carried out in the municipality of Trujillo (Valle del Cauca) through an ethnographic approach. The in-depth understanding of this process shows how the strategies implemented in the territory operate in the constitution of conditions for the production and reproduction of social life. [ABSTRACT FROM AUTHOR]

Copyright of Quaestio Iuris (QI) is the property of Editora da Universidade do Estado do Rio de Janeiro (EdUERJ) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and Objectives: Urinary Tract Infection (UTI) is one of the most common infections in the community and hospitalized patients. The aim of the present study was to investigate bacteria isolated from urinary tract infections and their antibiotic resistance in hospitalized patients. Subjects and Methods In the this descriptive-cross-sectional study, the results of about 5,000 urine samples sent for culture from the hospitalized patients of Golestan Hospital in Ahvaz in 2019 were examined. Relevant information was extracted from patients' medical records. Results Out of 5000 samples studied (39.7% female and 60.3% male), about 468 samples (9.36%) showed positive urine culture. Of the patients with UTI, 205 patients were women (43.8%). The risk of UTI increased with age. The most common bacteria caused urinary tract infections were E. coli with 51.5%, followed by Klebsiella with 29.3%. It was also observed that bacteria isolated from urine samples of people with UTI had antibiotic resistance, and for each bacteria special groups of antibiotics were more effective. Conclusion The prevalence of UTI in the studied patients was 9.36%. In females and with increasing age, the prevalence of UTI was higher. The most common bacteria that caused UTI were E. coli and then Klebsiella. Due to the fact that the resistance and sensitivity of bacteria to antibiotic used, it is recommended that the most common bacterial agents of UTI must be diagnosed and then the most appropriate antibiotic must be prescribed. [ABSTRACT FROM AUTHOR]

INTRODUCTION Pruritic urticarial papules and plaques of pregnancy (PUPPP) typically occur during the first pregnancy in the third trimester [1,2]. Papules and plaques of PUPPP are usually found on the abdomen within the striae associated with pregnancy but can extend to the limbs as well [1,3]. PUPPP is characterized by erythema as well as pruritic papules and plaques. Symptomatic treatment with oral antihistamines and topical corticosteroids preparations is usually offered to the pregnant mother as this eruption usually resolves rapidly within one to two weeks postpartum [2,3]. Persistence of the eruptions post-partum is rare. No risks or detrimental effects have been identified. Therefore, the perinatal outcome is excellent for both the mother and new-born baby [3,4]. This case report will review an unusual case of persistent PUPPP at 12 years post-partum in a 43 years old woman who continued to suffer from abrupt symptomatic outbreaks associated with PUPPP without any clear respite. This is unusual because 90% of PUPPP cases remit spontaneously with no recurrences. Keywords:

ObjectiveA low ankle-brachial index is associated with cardiovascular disease and reduced arterial compliance. A high ankle-brachial index is also associated with an increased risk of cardiovascular events. We tested the hypothesis that subjects with a high ankle-brachial index demonstrate a lower arterial compliance. In addition, we assessed whether pulse pressure amplification is increased among subjects with a high ankle-brachial index.MethodsWe studied 6814 adults enrolled in the Multiethnic Study of Atherosclerosis who were, by definition, free of clinical cardiovascular disease at baseline. Differences in total arterial compliance (ratio of stroke volume to pulse pressure), aortic and carotid distensibility (measured with magnetic resonance imaging and duplex ultrasound, respectively) were compared across ankle-brachial index subclasses (≤0.90, 0.91-1.29; ≥1.30) with analyses adjusted for cardiovascular risk factors and subclinical atherosclerosis.ResultsPeripheral arterial disease was detected in 230 (3.4%) and high ABI in 648 (9.6%) of subjects. Those with high ankle-brachial index demonstrated greater aortic/radial pulse pressure amplification than those with a normal ankle-brachial index. In adjusted models aortic and carotid distensibility as well as total arterial compliance, were lowest among those with ankle-brachial index≤0.9 (p

Starting from an ethnographic investigation with a cooperative of street hawkers from the Confederations of Workers of the Popular Economy (CTEP), this article explores the linkages between kinship, corporality and affections in the production of the common. I argue that this production entails the right to uphold a way of life that dates back at least three generations —the possibility of continuing to be—, as a starting point for a process of political experimentation to allow projecting a life worth living for themselves and for future generations, by producing rights and forms of collective wellbeing this population has historically been dispossessed of. More than thinking of the common as a given, this analysis seeks to contribute to a view of the common that serves the production process and focuses on the daily practices and relationships that shape it.

This article seeks to think of the common in a shift from the philosophical to the political. We begin with the contributions of Jean-Luc Nancy and Roberto Esposito to think of the common in ontological and impolitic terms. Next, we comment on Garrett Hardin’s theory of the tragedy of the commons and its rebuttal by Elinor Ostrom and others. Further on, we tackle the new wave of enclosures of the commons and the possibility of its reinvention to meet the expectations of the political, economic, social and environmental challenges of the XXI century. To this end, we comment on the reflections by Hardt and Negri, and Dardot and Laval, who theorize the common in political terms, emphasizing the dimension of instituent praxis.

After their marriage, the spouses seek to provide all what would extend peace and tranquility in their life, and they strive to provide the requirements of psychological comfort and a decent living for them and their children as a family where affection and mercy prevail, instead of looking for that with what they buy and provide from within the marital home, with the effort and money they have .But marital life may not succeed or continue, which leads to the dissolution of that marital bond and each party requesting his share of the furniture and household goods through the judiciary in accordance with Article 73 of the Family Code. In this study, we will stand on the provisions of the property ownership and to whom it devolves, the limits of the judge’s work in verifying them, and the extent of his application of the requirements of the text of Article 73 of the Family Law, and we will shed light on custom and the extent to which the community invokes it as a control of the parties’ commitment and as a basic determinant of the formation of the judge’s conviction in his judgment, in addition to taking into account not violating the provisions of Islamic law

Patient: Female, 40-year-old Final Diagnosis: Atrial myxoma, myocardial infarction Symptoms: Dry cough, shortness of breath, wheezing Medication: -- Clinical Procedure: -- Specialty: Cardiology, Pathology, Pulmonology Objective: Unusual clinical course Background: Although rare, atrial myxoma is the most common benign cardiac tumor. The recognized triad of presenting symptoms relates to constitutional, embolic, and obstructive effects produced by the tumor. However, the presentation may be non-specific and mimic other diseases, confounding diagnosis. Case Report: A middle-aged woman presented with wheezing and shortness of breath. With a strong background smoking history, the initial impression was that of acute bronchospasm. She however deteriorated rapidly, with decreased consciousness and cardiac arrest requiring resuscitation. Despite intensive care management, she died within 1 day of admission. Autopsy revealed a previously undiagnosed left atrial myxoma with coronary and systemic embolization. Conclusions: This case highlights an unusual presentation of atrial myxoma, resulting in fatal simultaneous embolization to the coronary and cerebral arteries. This simultaneous embolic presentation is not common, but the potential consequences are serious. This report also demonstrates that the presentation of a left-sided atrial myxoma with cardiac asthma can mimic respiratory disease and confound diagnosis. In adult patients without a history of chronic respiratory disease, the possibility of cardiac asthma should always be entertained. Furthermore, the importance of considering atrial myxoma as a cause for cardiac asthma is emphasized. The use of transthoracic echocardiogram in aiding the rapid diagnosis of atrial myxoma is recommended. Finally, the continued acknowledgement of the important contribution the academic autopsy makes in complementing and improving clinical practice remains imperative. [ABSTRACT FROM AUTHOR]

Copyright of Comunicação, Mídia e Consumo is the property of Escola Superior de Propaganda e Marketing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article argues that while creative spaces are believed to instigate creative production, their strongest value is in producing new possibilities for self-organizing. By zooming in on short snapshots of resistance against gentrification in creative spaces in Amsterdam, I investigate whether small-scale and grass-roots forms of resistance and self-organizing between independent workers in the creative industries can be understood as examples of the autonomist notions of 'the common' and 'the multitude'. By placing observations of creative workers' self-organizing practices alongside autonomist theory, I suggest that autonomist thought is a promising philosophy for a politicized view of creative production, because it celebrates multiplicity and uniqueness. This is a timely topic in a society with growing numbers of freelancers and increasing flexibilization of labour. This article contributes to research on self-organizing among creative workers and to the literature on work conditions in the creative industries. [ABSTRACT FROM AUTHOR]

Copyright of Revista Española de Sociología is the property of Federacion Espanola de Sociologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Española de Sociología is the property of Federacion Espanola de Sociologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Española de Sociología is the property of Federacion Espanola de Sociologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Low-intensity exercise with blood flow restriction (BFR) is an increasingly common method of improving muscular strength and hypertrophy, and improving aerobic fitness, in clinical and athletic populations. The aim of this systematic review was to describe common approaches to determining occlusion pressures for BFR exercise. A comprehensive literature search yielded 1389 results, of which 129 were included. Studies were predominantly randomised control trials (86.7%) with modest sample sizes (average number of 11.4 ± 6.2 participants per BFR group/s) of young adults (average age of 34.6 ± 17.9). Five different approaches for determining occlusion pressure were identified: arbitrary pressures (56.6%), percentage of limb occlusion pressure (25.6%), brachial systolic blood pressure (10.9%), perceived tightness (3.9%) and other (3%). From 2016 to 2018, the number of published papers using a percentage of limb occlusion pressure increased yearly, paralleling a decrease use of arbitrary pressures. Of the studies included in this review, the most common approach to determining occlusion pressure was using a non-individualised, arbitrary pressure. Given the safety concerns associated with arbitrary pressures, continual dissemination regarding the optimal applications of BFR for safety and efficacy is required. [ABSTRACT FROM AUTHOR]

Aim: Common pediatric surgical entities often get a delayed referral to the pediatric surgeon in the average Indian scenario. This study was conducted to assess the awareness about management of select common pediatric surgical entities among practicing pediatricians. Materials and Methods: An online multiple-choice questionnaire consisting of twenty questions related to the diagnosis and management of common pediatric surgical entities encountered by pediatricians in their routine office practice was prepared, and the electronic link was circulated among the practicing pediatricians of India. Each question had one correct response. Results: One hundred and seventy-five responses were obtained, collated, grouped, and analyzed. Overall, 35% of all responses were correct. Individually, 56% of respondents marked 51%–75% of answers correctly; only 7% scored above 75%. Some clinical observations were disparate: 65% were unfamiliar with preputial adhesions and 51% would discharge a preterm neonate with inguinal hernia without a surgical consult. There is a tendency toward unnecessary imaging (60% – localization of undescended testis, 91% – wet umbilicus, and 51% – postanal dimple) and overzealous medical management (propranolol for the involuting hemangioma). However, 82%–88% concurred on the standard conservative or surgical management in index conditions such as hypospadias and umbilical problems. Conclusion: There was a concurrence in the principles of management of common pediatric surgical entities between pediatricians and pediatric surgeons in 35%. Misdiagnosis, unwarranted investigations, overzealous medical management, and delayed surgical consults figured in 65%. A systematic professional interaction between the physicians and surgeons would facilitate a coordinated management. A larger study would yield more meaningful data. [ABSTRACT FROM AUTHOR]

An art of the everyday? Parting from Georges Perec and Vilhelm Hammershøi Contemporary continental philosophy seems to be deeply connected to art, whether it is poetry and literature (from Heidegger to Derrida), painting (Merleau-Ponty, Maldiney) or music (since Bergson). This connection is built upon the primacy of a trial of the invisible, which is very often a trial of the event. The aim of this article is to establish an art of the everyday freed from this contemporary "eventism". We thus examine how the researches of Georges Perec in literature and of Vilhelm Hammershøi in painting meditate on the strangeness of the everyday – its flatness, its silence – which are irreducible to this aesthetic trial as it can be conceptualized by the philosophy of the life of Deleuze-Guattari and by the humanism of Levinas. This research thus beckons towards an art of the common contesting the contemporary primacy of the vital and the (in)human.