476 results on '"Cirillo R"'
Search Results
102. Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine☆, ☆☆, ★, ★★
- Author
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DEPAULIS, A, primary, CICCARELLI, A, additional, DECRESCENZO, G, additional, CIRILLO, R, additional, PATELLA, V, additional, and MARONE, G, additional
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- 1996
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103. ChemInform Abstract: 4‐Diazinyl‐ and 4‐Pyridinylimidazoles: Potent Angiotensin II Antagonists. A Study of Their Activity and Computational Characterization.
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HARMAT, N. J. S., primary, GIORGI, R., additional, BONACCORSI, F., additional, CERBAI, G., additional, COLOMBANI, S. M., additional, RENZETTI, A. R., additional, CIRILLO, R., additional, SUBISSI, A., additional, ALAGONA, G., additional, GHIO, C., additional, ARCAMONE, F., additional, GIACHETTI, A., additional, PALEARI, F., additional, and SALIMBENI, A., additional
- Published
- 1995
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104. Pharmacology of LR-B/081, a new highly potent, selective and orally active, nonpeptide angiotensin II AT1 receptor antagonist
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Cirillo, R., primary, Renzetti, A.R., additional, Cucchi, P., additional, Guelfi, M., additional, Salimbeni, A., additional, Caliari, S., additional, Castellucci, A., additional, Evangelista, S., additional, Subissi, A., additional, and Giachetti, A., additional
- Published
- 1995
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105. Endothelium as a therapeutical target in peripheral occlusive arterial diseases: consideration for pharmacological interventions
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Cirillo, R., primary, Aliev, G., additional, Hornby, E.J., additional, and Prosdocimi, M., additional
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- 1994
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106. Changes in Vessel Ultrastructure during Ischemia and Reperfusion of Rabbit Hindlimb: Implications for Therapeutic Intervention
- Author
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Aliev, G., primary, Cirillo, R., additional, Salvatico, E., additional, Paro, M., additional, and Prosdocimi, M., additional
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- 1993
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107. Evidence for the presence of early vascular lesions in newborn Watanabe heritable hyperlipidemic (WHHL) rabbits
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Aliev, G., primary, Mironov, A., additional, Cirillo, R., additional, Gorelova, E., additional, and Prosdocimi, M., additional
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- 1993
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108. Relationship between nocturnal serum thyrotropin peak and metabolic control in diabetic patients.
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Bartalena, L, primary, Cossu, E, additional, Grasso, L, additional, Velluzzi, F, additional, Loviselli, A, additional, Cirillo, R, additional, and Martino, E, additional
- Published
- 1993
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109. Effect of Cloricromene During Ischemia and Reperfusion of Rabbit Hindlimb: Evidence for an Involvement of Leukocytes in Reperfusion-Mediated Tissue and Vascular Injury
- Author
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Cirillo, R, primary, Salvatico, E, additional, Aliev, G, additional, and Prosdocimi, M, additional
- Published
- 1992
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110. Evaluation of bone marrow cellularity by magnetic resonance imaging in patients with myelodysplastic syndrome
- Author
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Depaoli, L., primary, Ficara, F., additional, Priotto, C., additional, Resegotti, L., additional, Davini, O., additional, Foggetti, M. D., additional, and Cirillo, R., additional
- Published
- 1992
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111. Functional responses of hindlimb circulation in aged normal and WHHL rabbits
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Cirillo, R., primary, Aliev, G., additional, Italiano, G., additional, and Prosdocimi, M., additional
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- 1992
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112. Characterization of the anti-inflammatory effect of FK-506 on human mast cells.
- Author
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de Paulis, A, primary, Cirillo, R, additional, Ciccarelli, A, additional, de Crescenzo, G, additional, Oriente, A, additional, and Marone, G, additional
- Published
- 1991
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113. FK-506, a potent novel inhibitor of the release of proinflammatory mediators from human Fc epsilon RI+ cells.
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de Paulis, A, primary, Cirillo, R, additional, Ciccarelli, A, additional, Condorelli, M, additional, and Marone, G, additional
- Published
- 1991
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114. The Behaviour of Protein C in Diabetes Is still an Open Question
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Biondi, G, additional, Sorano, G G, additional, Conti, M, additional, Mameli, G, additional, Cirillo, R, additional, and Marongiu, F, additional
- Published
- 1991
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115. "Falsely Increased" B 15-42 Levels in Diabetes
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Marongiu, F., primary, Conti, M., additional, Mameli, G., additional, Sorano, G. G., additional, Cirillo, R., additional, and Balestrieri, A., additional
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- 1990
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116. Vasodilatator and vasoconstrictor responses of hindlimb circulation in WHHL rabbits
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Cirillo, R., primary, Italiano, G., additional, Norido, F., additional, and Prosdocimi, M., additional
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- 1990
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117. ChemInform Abstract: Synthesis and Antibronchospastic Activity of Theophylline Thioacetal Derivatives.
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GROSA, G., primary, CAPUTO, O., additional, CERUTI, M., additional, BIGLINO, G., additional, FRANZONE, J. S., additional, and CIRILLO, R., additional
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- 1990
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118. Is the imbalance between thrombin and plasmin activity in diabetes related to the behaviour of antiplasmin activity?
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Marongiu, F., primary, Conti, M., additional, Mameli, G., additional, Sorano, G.G., additional, Cossu, E., additional, Cirillo, R., additional, and Balestrieri, A., additional
- Published
- 1990
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119. Prevalence and molecular identification of Cryptosporidiumisolates from pet lizards and snakes in Italy
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Rinaldi, L., Capasso, M., Mihalca, A.D., Cirillo, R., Cringoli, G., and Cacciò, S.
- Abstract
In order to acquire prevalence and genetic data on Cryptosporidiuminfections in captive lizards and snakes kept as pets, a survey was conducted on 150 individual reptiles from southern Italy. Fecal samples were preserved in 5% formalin and analyzed using a commercial immunofluorescence assay (IFA) for the detection of Cryptosporidiumoocysts and Giardiacysts. IFA revealed the presence of Cryptosporidiumoocysts in nine of the 150 samples examined (6.0%), precisely in 6/125 snakes (4.8%) and in 3/25 lizards (12.0%); all fecal samples tested negative for the presence of Giardiacysts. Molecular characterization based on nested PCR amplification and sequencing of the SSU-rRNA gene, revealed the presence of Cryptosporidium serpentisin three samples from snakes (Boa constrictor constrictor, Elapheguttata guttata guttataand Python molurus).
- Published
- 2012
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120. Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man.
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Vigorito, C., Giordano, A., Cirillo, R., Genovese, A., Rengo, F., and Marone, G.
- Abstract
The time course of the effects of intravenous or intracoronary administration of peptide leukotrienes on metabolic parameters and on systemic and coronary hemodynamics was evaluated in 15 patients with normal coronary arteries. Peptide leukotriene C
4 (2 nmol given as a bolus intravenous injection) induced an early fall (at 2 min) in mean arterial pressure (P<0.02) associated with a rise in heart rate (P<0.001) and in plasma levels of epinephrine (P<0.05) and norepinephrine (P<0.005), but without significant changes in coronary blood flow or coronary vascular resistance. Mean arterial pressure, heart rate, norepinephrine, and epinephrine returned to baseline values 10 min after leukotriene C4 administration. In contrast, at 10 min post leukotriene C4 , with coronary blood flow and myocardial oxygen consumption unchanged, an increase in coronary vascular resistance (P<0.05) and in myocardial oxygen extraction (P<0.01) was observed, which returned to baseline values at 20 min post leukotriene C4 . Peptide leukotriene D4 (3 nmol, given in the left coronary artery) induced an early (20 s) and transient fall in mean arterial pressure (P<0.001 ) paralleled by a rise in heart rate and plasma levels of epinephrine and norepinephrine, all of which returned to baseline at 10 min. Coronary vascular resistance increased at 10 and 15 min (P<0.02 and P<0.05, respectively) and myocardial oxygen extraction at 15 min (P<0.02). These results suggest that small doses of peptide leukotrienes induce both an early and transient fall in mean arterial pressure associated with secondary sympathoadrenergic activation, and a late increase in small coronary arteriolar resistance. [ABSTRACT FROM AUTHOR]- Published
- 1997
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121. Selective Endoscopic Contrastography (S. E. C.): An Original Association of Radiology and Endoscopy of the Small and Large Intestine.
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Rossini, F. P., Ferrari, A., Mezzedimi, R., Cirillo, R., and Degiorgis, C.
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- 1979
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122. The Role of Coloscopy in the Differential Diagnosis Between Idiopathic Ulcerative Colitis and Crohn's Disease of the Colon.
- Author
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Banche, M., Rossini, F. P., Ferrari, A., Roatta, L., Gilli, E., and Cirillo, R.
- Subjects
COLONOSCOPY ,DIAGNOSIS ,COLITIS ,ULCERATIVE colitis ,CROHN'S disease - Abstract
The authors point out the striking significance of coloscopy in establishing a correct diagnosis of inflammatory diseases of the colon. In particular, the most valuable endoscopic features are indicated which may permit distinguishing between idiopathic ulcerative colitis and Crohn's disease of the colon. Differentiation between these two diseases cannot always be achieved by means of available diagnostic procedures other than coloscopy. Moreover, the endoscopic findings enable an assessment to be made of the extent, stage, severity and course of either disease. The authors' experience encompass 2,478 coloscopic examinations: the observed cases of idiopathic ulcerative colitis are 182, those of Crohn's disease of the colon are 104. [ABSTRACT FROM AUTHOR]
- Published
- 1976
123. Discovery and Development of a New Class of Potent, Selective, Orally Active Oxytocin Receptor Antagonists
- Author
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Quattropani, A., Dorbais, J., Covini, D., Pittet, P.-A., Colovray, V., Thomas, R. J., Coxhead, R., Halazy, S., Scheer, A., Missotten, M., Ayala, G., Bradshaw, C., Raemy-Schenk, A.-M. De, Nichols, A., Cirillo, R., Tos, E. G., Giachetti, C., Golzio, L., Marinelli, P., Church, D. J., Barberis, C., Chollet, A., and Schwarz, M. K.
- Abstract
We report a novel chemical class of potent oxytocin receptor antagonists showing a high degree of selectivity against the closely related vasopressin receptors (V1a, V1b, V2). An initial compound,
7 , was shown to be active in an animal model of preterm labor when administered by the intravenous but not by the oral route. Stepwise SAR investigations around the different structural elements revealed one position, the arenesulfonyl moiety, to be amenable to structural changes. Consequently, this position was used to introduce a variety of substituents to improve the physicochemical properties. Some of the resulting analogues were found to be superior to7 both in terms of potency in vitro and aqueous solubility, which translated into significantly improved efficacy in the animal model after intravenous and oral administration. The best compound,73 , potently inhibited oxytocin-induced uterine contractions in nonpregnant rats and reduced spontaneous uterine contractions in late-term pregnant rats.- Published
- 2005
124. Design and Synthesis of the First Generation of Novel Potent, Selective, and in Vivo Active (Benzothiazol-2-yl)acetonitrile Inhibitors of the c-Jun N-Terminal Kinase
- Author
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Gaillard, P., Jeanclaude-Etter, I., Ardissone, V., Arkinstall, S., Cambet, Y., Camps, M., Chabert, C., Church, D., Cirillo, R., Gretener, D., Halazy, S., Nichols, A., Szyndralewiez, C., Vitte, P.-A., and Gotteland, J.-P.
- Abstract
Several lines of evidence support the hypothesis that c-Jun N-terminal kinase (JNKs) plays a critical role in a wide range of diseases including cell death (apoptosis)-related disorders (neurodegenerative diseases, brain, heart, and renal ischemia, epilepsy) and inflammatory disorders (multiple sclerosis, rheumatoid arthritis, inflammatory bowel diseases). Screening of our internal compound collection for inhibitors of JNK3 led to the identification of (benzothiazol-2-yl)acetonitrile derivatives as potent and selective JNK1, -2, -3 inhibitors. Starting from initial hit
1 ( AS007149), the chemistry and initial structure−activity relationship (SAR) of this novel and unique kinase inhibitor template were explored. Investigation of the SAR rapidly revealed that the benzothiazol-2-ylacetonitrile pyrimidine core was crucial to retain a good level of potency on rat JNK3. Therefore, compound6 was further optimized by exploring a number of distal combinations in place of the chlorine atom. This led to the observation that the presence of an aromatic group, two carbons away from the aminopyrimidine moiety and bearing substituents conferring hydrogen bond acceptor (HBA) properties, could improve the potency. Further improvements to the biological and biopharmaceutical profile of the most promising compounds were performed, resulting in the discovery of compound59 (AS601245). The in vitro and in vivo anti-inflammatory potential of this new JNK inhibitor was investigated and found to demonstrate efficacy per oral route in an experimental model of rheumatoid arthritis (RA).- Published
- 2005
125. Pharmacology of MEN 11467: a potent new selective and orally- effective peptidomimetic tachykinin NK1receptor antagonist
- Author
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Cirillo, R., Astolfi, M., Conte, B., Lopez, G., Parlani, M., Sacco, G., Terracciano, R., Fincham, C.I., Sisto, A., Evangelista, S., Maggi, C.A., and Manzini, S.
- Abstract
We have investigated the pharmacological properties of MEN 11467, a novel partially retro-inverse peptidomimetic antagonist of tachykinin NK1receptors. MEN 11467 potently inhibits the binding of [3H] substance P (SP) to tachykinin NK1receptors in the IM9 limphoblastoid cell line (pKi= 9.4 ± 0.1). MEN 11467 is highly specific for the human tachykinin NK1receptors, since it has negligible effects (pKi<6) on the binding of specific ligands to tachykinin NK2or NK3receptors and to a panel of 30 receptors ion channels unrelated to tachykinin receptors. The antagonism exerted by MEN 11467 at tachykinin NK1receptors is insurmountable in saturation binding experiments, both KDand Bmaxof SP were significantly reduced by MEN 11467 (0.3–10nM). In the guinea-pig isolated ileum, MEN 11467 (0.03–1nM) produced a nonparallel rightward shift of the concentration–response curve to SP methylester with a concomitant reduction of the Emax to the agonist (pKB= 10.7 ± 0.1). Moreover the antagonist activity of MEN 11467 was hardly reversible despite prolonged washout. In vivo, MEN 11467 produced a long lasting (> 2–3h) dose-dependent antagonism of bronchoconstriction induced by the selective tachykinin NK1receptor agonist, [Sar9, Met(O2)11]SP in anaesthetized guinea-pigs (ID50s' = 29±5, 31±12 and 670±270μg/kg, after intravenous, intranasal and intraduodenal administration, respectively), without affecting bronchoconstriction induced by methacholine. After oral administration MEN 11467 produced a dose-dependent inhibition of plasma protein extravasation induced in guinea-pig bronchi by [Sar9, Met(O2)11] (ID50= 6.7 ± 2mg/kg) or by antigen challenge in sensitized animals (ID50= 1.3mg/kg). After i.v. administration MEN 11467 weakly inhibited the GR 73632-induced foot tapping behaviour in gerbil (ED50= 2.96 ± 2mg/kg), indicating a poor ability to block central tachykinin NK1receptors. These results demonstrate that MEN 11467 is a potent, highly selective and orally effective insurmountable pseudopeptide antagonist of peripheral tachykinin NK1receptors with a long duration of action.
- Published
- 2001
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- View/download PDF
126. Antinociceptive activity of ricinoleic acid, a capsaicin-like compound devoid of pungent properties
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Vieira, C., Evangelista, S., Cirillo, R., Terracciano, R., Lippi, A., Maggi, C. A., and Manzini, S.
- Published
- 2000
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127. Effect of MEN 11467, a new tachykinin NK1 receptor antagonist, in acute rectocolitis induced by acetic acid in guinea-pigs
- Author
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Cutrufo, C., Evangelista, S., Cirillo, R., Ciucci, A., Conte, B., Lopez, G., Manzini, S., and Maggi, C.A.
- Published
- 1999
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128. 35th Annual Meeting of the European Association for the Study of Diabetes
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Juhl, C., Pørksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th., Müller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Björn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H.-M., Oksanen, L., Tuomainen, T.-P., Kontula, K., Salonen, J. T., Dekker, J. M., de Boks, P., de Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D’Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., MacAlpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M., Kozáková, H., Kaas, A., Kofronová, O., Tlaskalová-Hogenová, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sørensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Haskó, G., Szabó, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Van Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H.-H., Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabák, Á. Gy., Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Cantón, A., Burgos, R., Hernández, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simó, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., McDermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y.-S., Sternesjö, J., Sandler, S., Chen, M.-C., Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Bréant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., van der Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, De Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessières-Lacombe, S., Tauber, J.-P., Home, P. D., Lindholm, A., Riis, A., Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Steiner, G., Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Vergès, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph., Benko, B., Ljubić, S., Turk, Z., Granić, M., März, W., Wollschläger, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O’Rahilly, S., Hattersley, A. T., McCarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., de Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Van Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Simán, C., Wisse, Bert, Gittenberger-de Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ożegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rość, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Škrha, J., Kvasnička, J., Kalvodová, B., Hilgertová, J., Schatteman, K., Goossens, F., Scharpé, S., De Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th. D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Häring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., McKinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnæs, A. M., Andersen, N. Aa., Osterhoff, M., Möhlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Fürnsinn, C., Nowotny, P., Waldhäusl, W., Roden, M., Neeft, M., Meijer, A. J., Båvenholm, P., Pigon, J., Efendic, S., Kästenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Van Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovská, A., Kasalicky, P., Hosová, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefèbvre, P. J., Greiner, D., Geenen, V., Atlan-Gepner, C., Naspetti, M., Valéro, R., Barad, M., Lepault, F., Vialettes, B., Naquet, P., de Galan, B., Netea, M. G., Hancu, N., Smits, P., Van der Meer, J. W. M., Osterbye, T., Jørgensen, K. H., Tranum-Jensen, J., Fredman, P., Høy, M., Bokvist, K., Olsen, H. 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Larsen, S., Olsen, S., Bombonato, G., Sacerdoti, D., Chiesura-Corona, M., Marangon, A., Rudberg, S., Rasmussen, L., Bangstad, H.-J., Ösrterby, R., Sivous, G. I., Kasatkina, E. P., Demurov, L. M., Nosikov, V. V., Kotova, A. K., Kuraeva, T. L., Mishina, I. I., Gorashko, N. M., Nosicov, V. V., Petercova, V. A., Berrut, G., Alhenc-Gelas, F., Tsimaratos, M., Gerbi, A., Barone, R., Ollerton, R. L., Playle, R. A., Luzio, S. D., Evans, W. D., Burch, A., Siebenhofer, A., Meinitzer, A., Brandmaier, H., Brunner, G., Plank, J., West, P., Tindall, H., McKenna, K., Smith, D., Tormey, W., Kesson, C. M., Thompson, C. J., Penno, G., Anichini, R., Bandinelli, S., Boldrini, E., Giannarelli, R., Piazza, F., Pucci, L., Karunakaran, S., Morris, R. J., Nádas, J., Farkas, K., Daróczy, A., Péterfai, É., Svensson, M., Weigert, C., Facchin, S., Gambaro, G., Brodbeck, K., Schleicher, E., Tada, H., Nomura, K., Kuboki, K., Tsukamoto, M., Inokuchi, T., Menè, P., Pugliese, F., Iino, K., Yoshinari, M., Iwase, M., Asano, T., Sonoki, K., Wakisaka, M., Takata, Y., Ujishima, M., Del Prete, D., Anglani, F., Antonucci, F., Mauri, J. M., Vallés, M., Gutiérrez, C., Vendrell, J., Shinada, M., Akdeniz, A., Panagiotopoulos, P., Bach, L. A., Law, V. A., Lecomte, P. P., Yokota, C., Okuda, Y., Odawara, M., Yamashita, K., Yamada, N., Kawai, K., Açbay, Ö., Mazlum, A., Kural, E., Gündoğdu, S., Jensen, C., Körner, A., Eklöf, A.-Ch, Jaremko, G., Lal, M., DiBona, G., Aperia, A., Yavuz, D. G., Tuncer, M., Sargon, M., Küçükkaya, B., Ahıskalı, R., Akalın, Sema, Nohara, E., Oates, P. J., Ellery, C. A., Yonem, A., Azal, O., Cakýr, B., Erdogan, M. F., Corakcý, A., Ozdemir, I. C., Stevens, R. J., Yudkin, J. S., Webber, J., Wheeler, D. C., Taylor, K. G., Jones, S. L., Srivatsa, A., Anderson, S. G., Cruikshank, J. K., Florkowski, C. M., Scott, R. S., Graham, P. J., Moir, C. L., Flores, C., Ruggenenti, P., Dodesini, A. R., Vasile, B., Gaspari, F., Arnoldi, F., Ferrari, S., Ciocca, I., Spalluzzi, A., Remuzzi, G., Delvigne, C., Ballaux, D., Bosman, D. R., Winkler, A. S., Marsden, J., Watkins, P. J., Strutton, D., Erbey, J. R., Jacobsen, P., Rossing, K., Jensen, J. S., Mansfield, M. W., Kowalska, I., Telejko, B., Bachórzewska-Gajewska, A., Prokop, J., Kochman, W., Musiał, W., Naskręt, D., Oleksa, R., Zozulińska, D., Sowiński, J., Wierusz-Wysocka, B., Klamann, A., Jonas, M., Müller-Lung, U., Heuser, L., Launhardt, V., Valensi, P., Pariès, J., Torremocha, F., Brulport, V., Sachs, R. N., Vanzetto, G., Levy, M., Lormeau, B., Halimi, S., Perfornis, A., Boumal, D., Zimmermann, C., Bernard, Y., Sabbah, A., Meneveau, N., Gautier, S., Bassand, J. P., Anděl, M., Kraml, P., Potočková, J., Dvořáková, H., Trešlová, L., Nuttall, S. L., Martin, U., Kendall, M. J., Schiaffini, R., Pantaleo, A., Battocletti, T., Vaccari, V., Brufani, C., Martuscelli, E., Gargiulo, P., Nieszner, E., Posa, I., Kocsis, E., Préda, I., Pogatsa, G., Koltai, M. Z. S., Stefanidis, A., Manoussakis, S., Handanis, S., Zairis, M., Vitalis, D., Dadiotis, L., Fiorina, P., La Rocca, E., Astorri, E., Rossetti, C., Lucignani, G., Giudici, D., Castoldi, R., Mazarakis, N., Giagiakou, E., Karavidas, A., Agellou, A., Karamani, O., Matsakas, E., Caviezel, F., Morricone, L., Ranucci, M., Denti, S., Cazzaniga, A., Enrini, R., Isgrò, G., González de Molina, F. J., Sala, J., Masià, R., Marrugat, J., Kruszewski, P., Wolnik, B., Bieniaszewski, L., Świerblewska, E., Semetkowska-Jurkiewicz, E., Krupa-Wojciechowska, B., Vasilikos, P. G., Alaveras, A. E. G., Anastasopoulos, N. G., Chala, E., Sidira, M., Christakopoulos, P. D., Poulsen, P. L., Hansen, K. W., Ebbehøj, E., Knudsen, S. T., Mogensen, C. E., Ramu, Y., Vidyullatha, Y., Strojek, K., Gorska, J., Morawin, E., Ritz, E., Ciavarella, A., Malini, P. L., Strocchi, E., Fiumi, N., Ambrosioni, E., Idzior-Waluś, B., Stevens, L., McEneny, J., O’Kane, M. J., Moles, K. W., McMaster, C., Young, I. S., Leonhardt, W., Konstadelou, E., Gürlek, Alper, Soedamah-Muthu, S., Taskinen, M. R., Ehnholm, C., Wägner, A., Bayen, Laia, Rigla, M., Ortega, E., Caixàs, A., Mestrón, A., Ordóñez, J., Pérez, A., Sotiropoulou, G., Servais, P. L., Bertolotto, A., Pilo, M., Suchánková, G., Andratschke, S., Tschöp, M., Strasburger, C.-J., Rizzo, L., Aerts, P., Vinckx, M., Ansquer, J. C., Ryan, M., Buter, H., Navis, G. J., de Jong, P. E., de Zeeuw, D., Carreras, G., Giménez, G., Pou, J. M., Howorka, K., Gabriel, M., Pumprla, J., Köves, A., Bhowmik, N. B., Haque, A., Rahman, A., Paleari, F., Gamba, P., Mauri, G., Rovaris, G., Giannattasio, C., Piatti, M. L., Zincone, A., Cavaletti, G., Mancia, G., Lan, S., Arezzo, J., Gerber, R. A., Klioze, S. S., Saponara, C., Tartaglione, T., Cercone, S., Caputo, S., Meloni, T., Brunetti, D., Di Lazzaro, V., Xu, G., Jiang, H. Y., Shy, M. E., Sugimoto, K., Zhang, W.-X., Kuchmerovskaya, T., Donchenko, G., Shymansky, I., Kuchmerovsky, N., Pakyrbaeva, L., Cameron, N. E., Keegan, A., Cotter, M. A., Mirrlees, D., Smale, S. E., Biessels, G. J., Duis, S. E. J., Kamal, A., Gispen, W. H., Carrington, A., Carman, S., Smiarowski, H., Lavoie, D., Sawicki, D., Sabetta, A., Litchfield, J., Van Zandt, M., Sredy, J., Smirnova, V., Strokov, I., Ivanova, L., Ichunina, A., Nakamura, J., Nakayama, M., Hamada, Y., Chaya, S., Kato, K., Kasuya, Y., Mizubayashi, R., Miwa, K., Yasuda, Y., Kamiya, H., Hotta, N., Bíró, K., Kukorelli, T., Szilágyi, N., Kürthy, M., Komáromy, A., Mogyorosi, T., Nagy, K., Çakir, M., Baskal, N., Güllü, S., Elhan, A. H., Erdogan, G., Ziegler, D., Piolot, R., Neubauer, J., Senesi, B., Bonetti, R., Napolitano, A., Canepa, F., Ottonello, P., Schabmann, A., Giménez-Pérez, G., Arroyo, J. A., López, T., Ponz, E., Mauricio, D., Diem, P., Zanchin, L., Suter, S. L., Lefrandt, J. D., Smit, A., van Roon, A. M., Dullaart, R., Voita, D., Mackevics, V., Vitols, A., Lengyel, Cs., Farkas, Gy., Török, T., Légrády, P., Várkonyi, T. T., Kardos, A., Gingl, Z., Kempler, P., Rudas, L., Lonovics, J., Marchand, M., Stevens, L. K., Tarnás, Gy., Estrella, F., Christensen, N. J., Keresztes, K., Barna, I., Hermányi, Zs., Vargha, P., Bonnevie, L., Chanudet, X., Larroque, P., Tutuncu, N. Bascil, Deger, A., Batur, M. K., Yildirir, A., Onalan, O., Aksöyek, S., Kabakçι, G., Erbaş, T., Galicka-Latała, D., Surdacki, A., Gerritsen, J., TenVoorde, B. J., Heethaar, R. M., Tagawa, T. S., Kodama, M., Yoshioka, R., Yamasaki, Y., Didangelos, T., Athyros, V., Kontopoulos, A., Papageorgiou, A., Karamitsos, D., Lacigová, S., Rušavý, Z., Kárová, R., Perrild, H., Kay, L., Jørgensen, T., Bień, A. I., Witek, P., Geraldes, Elizabete, Rodrigues, D., Pereira, L., Doménech, A., Leitão, P., Anagnostopoulos, D., Foster, A. V. M., Nag, S., Barsoum, M., Lewis, G., Dunlop, N., Connolly, V., Bilous, R., Kelly, W., Chantelau, E., Gede, A., Sharman, D., O’Halloran, D., Best, C., Abbas, Z. G., Lutale, J., Gill, G. V., Jarvis, W. R., Archibald, L. K., Corcoran, S., Mansell, J., Pibworth, L., Terada, H., Shiba, T., Utugi, N., Utugi, T., Blum, M., Strobel, J., Höffken, K., Razvi, F. M., Kritzinger, E. E., Taylor, K., Jones, S., Illahi, W., Grüβer, M., Hartmann, P., Hoffstadt, K., van Leiden, H. A., Moll, A. C., Polak, B. C. P., Pietragalla, G. B., Maurino, M., Montanaro, M., Karadeniz, Ş., Tommasini, P., Quadrini, C., Demiraj, V., Rispoli, E., Ota, A., Takama, H., Saito, N., Hemández, C., Lepore, D., Antico, L., Giardina, B., Franconi, F., Michoud, E., Chamot, S., Riva, Ch., Hammes, H.-P., Renner, O., Breier, G., Lin, J., Alt, A., Betzholtz, C., Bretzel, R. G., Manti, R., Gallo, M., Molinar Hin, A., Brignardello, E., Boccuzzi, G., Li, Shanfang, Xiang, Kunsan, Zhang, Rugeng, Shangguan, Xinhong, Wu, Jianrong, Donnan, P. T., Broomhall, J., Hunter, K., Morris, A. D., Ioannidis, G., Peppa, M., Rontogianni, E., Kallifronas, M., Lekatsas, I., Chrysanthopoulou, G., Anthopoulos, L., Kesse, M., Thalassinos, N., Neves, C., Medina, J. L., Lopes, F., Yılmaz, M., Güvener, N., Güvener, M., Kocagöz, T., Böke, E., Paşaoglu, I., Bascil Tutuncu, N., Oto, A., Karvonen, M. K., Koulu, M., Pesonen, U., Mercuri, M., Rauramaa, R., Rutter, M. K., Kestevan, P., McComb, J. M., Marshall, S. M., Sobieska, M., Wiktorowicz, K., Kanters, S. D. J. M., Banga, J. D., Algra, A., Frijns, C. J. M., Beutler, J. J., Fijnheer, R., Nicoloff, G., Baydanoff, S., Stanimirova, N., Petrova, Ch., Lario, S., Campistol, J. M., Cases, A., Clària, J., Iñigo, P., Esmatjcs, E., Sármán, B., Tóth, M., Kocsis, I., Somogyi, A., Bumbure, A., Jachimowicz, K., Samson, J., Tomasiak, M., Sobol, A., Stańczyk, L., Watala, C., Stradina, P., Wiśniewska-Jarosińska, M., Marciniak, D., Więcławska, B., Watała, C., Golański, J., Zinnat, R., Mahmud, I., Büyükasik, Yahya, Demiroğlu, H., Szczepanik, A., Skowroński, M., Murawska, A., Meeking, D. R., Allard, S., Munday, J., Chowienczyk, P., Shaw, K. M., Cummings, M. H., Šimková, R., Jirsa, M., Hadoke, P. W. F., McIntyre, C. A., Jones, G. C., Williams, B. C., Elliott, A. I., McKnight, J. A., Pernow, J., Bombonato, G. C., Finucci, G. F., Zotta, L., Senses, V., Ozyazgan, S., Ince, E., Tunçdemir, M., Oztürk, M., Sultuybek, G., Akkan, A. G., Özyazgan, S., Unlücerci, Y., Bekpınar, S., Meyer, M. F., Lee, B. C., Shore, A. C., Humphreys, J. M., Tooke, J. E., Dell’Omo, G., Giovannitti, G., Caricato, F., Mariani, M., Pedrinelli, R., Kiviet-Boehm, C., Schwelling, V., Matthäei, S., Pfohl, M., McInerney, D., Itoh, H., Ohno, T., Katoh, N., Baumgartner-Parzer, S., Artwohl, M., Graier, W., Ludwig, C., Tachi, Y., Bannai, C., Shinohara, M., Shimpuku, H., Ohura, K., Bertacca, A., Sasvári, M., Szaleczki, E., Pusztai, P., Boes, U., Klaus, E., Dittrich, P., Wagner, Z., Wittmann, I., Pótó, L., Wagner, L., Mazák, I., Nagy, J., Feletto, F., Taboga, C., Tonutti, L., Lizzio, S., Russo, A., Selmo, V., Ceriello, A., Lekakis, J., Papamichael, C. M., Stamatelopoulos, K., Stamatelopoulos, S., Yillar, D. O., Gay, M., Lillaz, E., Passaro, A., Vanini, A., Calzoni, F., D’Elia, K., Carantoni, M., Zuliani, G., Fellin, R., Solini, A., Chwatko, G., Bald, E., Dramais, A.-S., Wallemacq, P. E., Vandeleene, B., Ciaria, M. V., Ariano, M., Strom, R., Gibney, J., Weiss, U., Turner, B., O’Gorman, P., Watts, G., Powrie, J., Crook, M., Shaw, K., and Cummings, M.
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- 1999
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129. Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine
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de Paulis, A., Ciccarelli, A., de Crescenzo, G., Cirillo, R., Patella, V., and Marone, G.
- Abstract
Background:Cyclosporin A (CsA) binds with high affinity to cyclophilin, a critical step in the molecular mechanism of action of cyclosporins, whereas cyclosporin H (CsH) has extremely low affinity for cyclophilin. CsH differs from CsA by the substitution of the L-methyl valine at position 11 with its D-isomer. Methods: We compared the effects of CsA and CsH on the release of preformed (histamine) and de novo synthesized inflammatory mediators (peptide leukotriene C "4) from peripheral blood basophils activated by N-formyl-methionyl-leucyl-phenylalanine (FMLP). Results: CsH (8 to 800 nmol/L) concentration-dependently inhibited histamine and leukotriene C "4 release from purified and unpurified basophils activated by FMLP, whereas CsA (8 to 800 nmol/L) had little inhibitory effect on histamine release from basophils challenged with FMLP. Inhibition of histamine release from basophils challenged with FMLP was extremely rapid and was abolished by washing the cells (three times) before challenge. CsH (8 to 800 nmol/L) had no effect on the release of histamine caused by C5a, platelet activating factor, monocyte chemotactic activating factor, RANTES, IL-8, bryostatin 1, and phorbol myristate. Preincubation of basophils with granulocyte-macrophage colony-stimulating factor (30 and 100 pmol/L), but not IL-1@b (30 and 100 ng/ml), concentration-dependently reversed the inhibitory effect of CsH on FMLP-induced histamine release. CsH competitively inhibited the effect of FMLP on histamine release from basophils. The dissociation constant (K "d) for the CsH-FMLP receptor complex was approximately 9 x 10^-^8 mol/L, more than 10-fold lower than that (@? 1.3 x 10^-^6 mol/L) of N-t-BOC-methionyl-L-leucyl-phenylalanine (BocMLP), a known formyl peptide receptor antagonist. CsH inhibited tritiated FMLP binding to human polymorphonuclear leukocytes with a concentration required to inhibit binding by 50% of approximately 5.4 x 10^-^7 mol/L, whereas BocMLP was less potent with a concentration required to inhibit binding by 50% of approximately 9.1 x 10^-^5 mol/L. Scatchard analysis revealed that the decreased tritiated FMLP binding caused by CsH was due to a decrease in the B "m"a"x (0.22 +/- 0.04 nmol/L/5 x 10^6 cells vs 0.09 +/- 0.01 nmol/L/5 x 10^6 cells; p < 0.05), without a significant difference in the K "d (5.16 +/- 1.22 nmol/L vs 6.32 +/- 2.42 nmol/L; p = NS). Conclusions: CsH is a potent and selective inhibitor of mediator release from basophils induced by activation of the formyl peptide receptor; it acts by interfering with agonist binding to FMLP receptors. (J ALLERGY CLIN IMMUNOL 1996;98:152-64.)
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- 1996
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130. Pharmacology of the peptidomimetic, MEN 11149, a new potent, selective and orally effective tachykinin NK~1 receptor antagonist
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Cirillo, R., Astolfi, M., Conte, B., Lopez, G., Parlani, M., Terracciano, R., Fincham, C. I., and Manzini, S.
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- 1998
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131. Functional evidence for the ability of angiotensin AT~1 receptor antagonists to cross the blood-brain barrier in rats
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Polidori, C., Ciccocioppo, R., Pompei, P., Cirillo, R., and Massi, M.
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- 1996
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132. Castleman Disease Mimicking a Hepatic Neoplasm
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Cirillo, R. L., Vitellas, K. M., Deyoung, B. R., and Bennett, W. F.
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- 1998
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133. Characterization of tachykinin NK~2 receptor on dog proximal colon. Antagonism by MEN 10,627 and SR 48,968
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Parlani, M., Conte, B., Cirillo, R., and Manzini, S.
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- 1996
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134. The effect of transdermal 17- -estradiol on glucose metabolism of postmenopausal women is evident during the oral but not the intravenous glucose administration
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Cagnacci, A., Tuveri, F., Cirillo, R., Setteneri, A. M., Melis, G. B., and Volpe, A.
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- 1997
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135. Antiinflammatory effect of FK 506 on human basophils
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Amato de Paulis, Cirillo, R., Ciccarelli, A., Columbo, M., Marone, G., DE PAULIS, Amato, Cirillo, R, Ciccarelli, A, Columbo, M, and Marone, G.
- Subjects
Mites ,Anti-Inflammatory Agents, Non-Steroidal ,Allergens ,Immunoglobulin E ,In Vitro Techniques ,Bryostatins ,Histamine Release ,Tacrolimus ,Basophils ,N-Formylmethionine Leucyl-Phenylalanine ,Kinetics ,Lactones ,Adjuvants, Immunologic ,Animals ,Humans ,SRS-A ,Antigens, Dermatophagoides ,Macrolides ,Calcimycin
136. Lack of saccadic abnormalities in central pontine myelinolysis: report of a case
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Tedeschi, G, Sasso, E, DI COSTANZO, Alfonso, Allocca, S, Casucci, G, Cirillo, R, and Bonavita, V.
- Published
- 1988
137. Environmental Dynamics of Heavy Metals: Experimental Approach for the Determination of the Role of Humic Acids in the sediments
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Perin, Guido, Craboledda, L., Carniel, A., and Cirillo, R.
- Published
- 1985
138. Heavy Metal Speciation in the Sediments of Northern Adriatic Sea: A new Approach for Environmental Toxicity Determination
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Perin, Guido, Craboledda, L., Lucchese, M., Cirillo, R., and Dotta, L.
- Published
- 1985
139. Accelerometria computerizzata del tremore posturale parkinsoniano: effetto acuto di L-Dopa
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Sasso, E, Tedeschi, G, DI COSTANZO, Alfonso, Cirillo, R, Marshall, R, and Bonavita, V.
- Published
- 1987
140. Environmental dynamics of heavy metals: experimental approach for the determination of the role of humic acids in sediments
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Perin, Guido, Craboledda, L., Carniel, A., and Cirillo, R.
- Published
- 1985
141. Selective endoscopic contrastography (S.E.C.): an original association of radiology and endoscopy of the small and large intestine
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Mezzedimi R, Cirillo R, Ferrari A, Rossini Fp, and Degiorgis C
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Gynecology ,medicine.medical_specialty ,Sigmoid Diseases ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Contrast Media ,Endoscopy ,Constriction, Pathologic ,Middle Aged ,Surgery ,Radiography ,medicine.anatomical_structure ,Ileum ,Intestine, Small ,Medicine ,Humans ,Large intestine ,Female ,Intestine, Large ,business - Abstract
A more complete diagnostic information can be obtained by “carrying” the contrast medium through the fibercoloscope to those sites of the bowel where neither radiology alone nor endoscopy alone succeed in solving the diagnostic problem. The indications for a selective perendoscopic contrast study during coloscopy are few, but well-defined and certainly not negligible: — demonstration and assessment of stenoses (unclarified by radiology and endoscopy); — accurate evaluation of the last ileal loop; — diagnostic study of ileo-colic surgical anastomoses; — fistulous tracts. Seventy-six patients were examined, without complications. The method proved useful in 42% of cases, conclusive in 33%, useless or inconclusive in 17%, unsuccessful in 8% (technical difficulties). On this basis, selective endoscopic contrastography is considered of use whenever its specific indications apply. Eine umfassendere diagnostische Information kann dadurch erzielt werden, das man das Kontrastmittel durch das Fiberskop an die Stellen des Darmes bringt, wo weder Radiologie noch Endoskopie allein geeignet sind, das diagnostische Problem zu losen. Die Indikationen zu einer selektiven endoskopischen Kontrastuntersuchung wahrend der Coloskopie sind gering, aber gut definiert, und sollten nicht vernachlassigt werden: Demonstration und Darstellung von Stenosen (nicht geklart durch Radiologie oder Endoskopie), exakte Abklarung der letzten Ileumschlinge, Diagnostik von chirurgischen ileo-colischen Anastomosen, Fistelgange. 76 Patienten sind bisher ohne Komplikationen untersucht worden: Die Methode hat sich als nutzlich erwiesen in 42%, schlussig in 33%, nutzlos oder nicht beweisend in 17% und erfolglos in 8% (technische Probleme) der Falle. Auf dieser Grundlage wird die selektive endos-kopische Kontrastographie als nutzlich angesehen, wenn die erwahnten Indikationen vorliegen.
- Published
- 1979
142. Synthesis and antiinflammatory activity of some N-(5-substituted indole-3-ylglyoxyl)amine derivatives
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Da Settimo, A., Primofiore, G., Marini, ANNA MARIA, Mori, C., Franzone, J. S., Cirillo, R., and Reboani, C.
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Male ,Chemistry ,Mice ,Indoles ,Chemical Phenomena ,Anti-Inflammatory Agents, Non-Steroidal ,Reaction Time ,Animals ,Edema ,Glyoxylates ,Rats, Inbred Strains ,Carrageenan ,Rats - Abstract
The synthesis of some amidic derivatives, obtained by condensation of various 5-substituted indoleglyoxylchlorides with physiologically important amines as tyramine, tryptamine and 5-aminouracil, is described. The preparation of one glycolyl derivative is also reported. Study of analgesic and antiinflammatory properties has shown only a feeble activity of these compounds.
- Published
- 1987
143. IgE-mediated activation of human heart in vitro.
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Marone, G., Triggiani, M., Cirillo, R., Giacummo, A., Hammarström, S., and Condorelli, M.
- Abstract
We used human cardiac tissue from the right atrial appendages of patients undergoing corrective heart surgery to study content and de novo synthesis of mediators in the human heart. Human heart tissue contained 1.7±0.1 μg/g wet weight of histamine (mean±S.E.M.) and spontaneously produced 6-keto-PGF (38.4 ng/g wet weight/min), PGF (1.9 ng/g wet weight/min), PGE (1.7 ng/g wet weight/min) and thromboxane B (T×B) (1.7 ng/g wet weight/min). Spontaneous release of PGD, leukotriene C and histamine was negligible. Rabbit anti-human IgE (1-10 μg/ml) dose-dependently induced the release of histmaine (5 to 15% of the total histamine content) and of PGD (5 to 100 ng/g of wet tissue). The effect of anti-IgE was dose-related and reached a maximum after 30-45 min of incubation. A significant linear correlation (r=0.90; p<0.001) was found between de novo synthesis of PGD and the secretion of histamine induced by anti-IgE challenge of human heart. These results support the concept that PGI is the main, but not the sole, product of arachidonic acid metabolism synthesized by human heart in vitro. Additionally, anti-IgE challenge of human heart in vitro induces the release of histamine and PGD. The local concentrations of these mediators appear high enough to play some role in the modulation of several cardiac functions in vivo. [ABSTRACT FROM AUTHOR]
- Published
- 1986
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144. Hypoglycemic effect of adipose tissue extracts (ATE) in rats.
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Lenti, G., Pellegrini, A., Pagano, G., Zizi, P., Cirillo, R., and Mascia, V.
- Published
- 1968
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145. Airport Vicinity Air Pollution Study.
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ARGONNE NATIONAL LAB ILL ENERGY AND ENVIRONMENTAL SYSTEMS DIV, Rote,D. M., Hecht,R. W., Wang,I. T., Cirillo,R. R., Wangen,L. E., ARGONNE NATIONAL LAB ILL ENERGY AND ENVIRONMENTAL SYSTEMS DIV, Rote,D. M., Hecht,R. W., Wang,I. T., Cirillo,R. R., and Wangen,L. E.
- Abstract
The report describes the development of a computer model that can be used to determine the impact of an existing or planned airport on the air quality in its vicinity. The model development was supported by an air quality monitoring and emission activity data acquisition program. O'Hare International Airport, Chicago, Illinois, and Orange County Airport, Los Angeles, California was selected as test sites, each being representative of a predominantly commercial airport and a predominantly general aviation report, respectively. The activity simulation and air quality model are discussed. Results of the computations of air quality concentrations and comparisons with observations are presented. (Author)
- Published
- 1973
146. Malta and the Maltese--A Study in Nineteenth Century Migration. Charles A. Price
- Author
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Cirillo, R.
- Published
- 1956
- Full Text
- View/download PDF
147. Dermatan Sulphate, Heparin Cofactor II, and F1+2 Peptide in Non-Insulin-Dependent Diabetes Mellitus - The Framingham experience
- Author
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Mascia, F., Paoletti, P., Mameli, G., Mamusa, A.M., Cirillo, R., and Marongiu, F.
- Published
- 2000
- Full Text
- View/download PDF
148. Serological and molecular studies of HLA in insulin-dependent diabetes mellitus in Sardinia
- Author
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Giorgio La Nasa, Carcassi C, Cirillo R, Mulargia M, Al, Leone, Vacca A, Pizzati A, Boero R, Arras M, and Porcella R
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Base Sequence ,Molecular Sequence Data ,Diabetes Mellitus, Type 1 ,HLA-DR3 Antigen ,Gene Frequency ,Haplotypes ,Italy ,HLA Antigens ,HLA-DQ Antigens ,HLA-DQ beta-Chains ,Humans ,Genetic Predisposition to Disease ,Oligonucleotide Probes ,Alleles - Abstract
This study was carried out in Sardinia, an Italian region with a very high IDDM incidence. HLA class I and class II antigens were studied in 97 unrelated IDDM patients, 33 complete families with at least one affected member each, and 559 healthy controls. Molecular typing of the DQB1 alleles was carried out in 31 patients and 61 controls. The haplotypes were determined by family studies. The HLA-DR3, DQw2, and DR4 antigens were positively associated with IDDM. The DR3 antigen was nearly always associated to B18 and frequently carried by the extended haplotype A30 Cw5 B18 3F130 DR3 DQw2. The genotype analysis of the patients showed a strong increase of the DR3/DR4 heterozygotes with a relative risk higher than that of the DR3 and DR4 homozygotes. The DR2 antigen was negatively associated with IDDM in the central island districts but not in the southern districts. The DQB1 molecular analysis showed only three alleles in the patients: DQB1*0201 (75.8 per cent), DQB1*0302 (16.1 per cent), and DQB1*0502 (8.1 per cent). These alleles are non Asp 57, so it would seem that nearly if not all Sardinian IDDM patients are NA/NA homozygotes. The DQB1*0502 allele, extremely rare in other Caucasian populations, represents in Sardinia about 70 per cent of the HLA-DR2 haplotypes, contributing to the increase of the pool of IDDM susceptible genes. Moreover it is carried in 27 per cent of the DR2 positive individuals with the extended haplotype A2 Cw7 Bw58 3F31 DR2 DQw1.AZH.
149. Zoonotic protozoa in marine and lagoon shellfish: molecular study for the evaluation of the environmental pollution and risk for human consumption
- Author
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SOCIETÀ ITALIANA DI PARASSITOLOGIA (SOIPA), Giangaspero, A., Di Cave, D., MARIALETIZIA FIORAVANTI, Frangipane Di Regalbono, A., Berrilli, F., Monica Caffara, Cirillo, R., Granato, A., Marangi, M., Paoletti, B., Perrucci, S., Zanutto, S., and Capelli, G.
150. Serological and molecular studies of HLA in insulin-dependent diabetes mellitus in Sardinia
- Author
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La Nasa, G., Carlo Carcassi, Cirillo, R., Mulargia, M., Leone, A. L., Vacca, A., Pizzati, A., Boero, R., Arras, M., Porcella, R., Floris, L., Orru, S., Mura, C., Trucco, M., and Contu, L.
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