539 results on '"Christine Ho"'
Search Results
102. The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression
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Meng Xu, Taku Ito-Kureha, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai P. Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, and Vigo Heissmeyer
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Science - Abstract
Abstract The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows selective and dynamic expression in early thymocytes. Arpp21 is downregulated in response to T cell receptor (TCR) and Ca2+ signals. Downregulation requires Stim1/Stim2 and CaMK4 expression and involves Arpp21 protein phosphorylation, polyubiquitination and proteasomal degradation. Arpp21 directly binds RNA through its R3H domain, with a preference for uridine-rich motifs, promoting the expression of target mRNAs. Analysis of the Arpp21–bound transcriptome reveals strong interactions with the Rag1 3′-UTR. Arpp21–deficient thymocytes show reduced Rag1 expression, delayed TCR rearrangement and a less diverse TCR repertoire. This phenotype is recapitulated in Rag1 3′-UTR mutant mice harboring a deletion of the Arpp21 response region. These findings show how thymocyte-specific Arpp21 promotes Rag1 expression to enable TCR repertoire diversity until signals from the TCR terminate Arpp21 and Rag1 activities.
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- 2024
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103. Allied health professionals’ experiences and views towards improving musculoskeletal services in the UK for patients with musculoskeletal and co-existing mental health conditions: a qualitative study
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Rokhsaneh Tehrany, Dana Maki, Maria J C Teixeira, Tanya Chumak, and Christine Hoerz
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Anxiety ,Allied Health Professionals ,Depression ,Mental Health ,Musculoskeletal ,Perception ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Interplay between physical and mental health (MH) is widely recognised amongst patients with Musculoskeletal and co-existing MH conditions. Evidence suggests that psychological interventions improve outcomes and satisfaction in patients with physical conditions, however current healthcare models continue to separate physical and mental health care, as health services are fragmented. If the delivery of MH support could be facilitated by Allied Health Professionals (AHPs), such as physiotherapists and occupational therapists (OTs), this could be an effective, low-cost way to achieve routine integration. This study aimed to explore the experiences of UK physiotherapists and OTs working with patients with MSK and co-existing MH conditions and to understand views on improving MSK services. Methods This was an exploratory-descriptive qualitative study using semi-structured interviews. Participants were recruited via social media and professional organisations using convenience sampling. Participants included registered UK physiotherapists or OTs within MSK settings who managed patients with MH conditions. Inductive thematic analysis was used, where single and double-level coding, single counting and inclusion of divergent cases were conducted to enhance methodological rigour. Results Three overarching themes were identified. Overarching theme one referred to openness to provide MH support, with scope of practice and lack of confidence as themes. Overarching theme two described challenges, incorporating mental health stigma, the clinical environment, and limited experience. The overarching theme referring to training, identified the need for further training and strategies to implement as themes. Conclusion Many challenges to achieving optimal integration of physical and mental health care exist within MSK services. These challenges go beyond the need for additional training and knowledge acquisition and include departmental readiness such as funding, diary management, and supervision by senior colleagues/or psychologists. These need consideration in parallel to match the evolving needs of the MSK population.
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- 2024
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104. Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset
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Catherine Kim, Kylie K. Harrall, Deborah H. Glueck, Christine Hockett, and Dana Dabelea
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Medicine ,Science - Abstract
Abstract Using data from a longitudinal cohort of children, we examined whether epigenetic age acceleration (EAA) was associated with pubertal growth and whether these associations were mediated by adiposity. We examined associations between EAA at approximately 10 years of age with pubertal growth metrics, including age at peak height velocity (PHV), PHV, and sex steroid levels and whether these associations were mediated by measures of adiposity including body mass index (BMI) and MRI-assessed visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Children (n = 135) with accelerated EAA had higher PHV (β 0.018, p = 0.0008) although the effect size was small. The association between EAA and age at PHV was not significant (β − 0.0022, p = 0.067). Although EAA was associated with higher BMI (β 0.16, p = 0.0041), VAT (β 0.50, p = 0.037), and SAT (β 3.47, p = 0.0076), BMI and VAT did not mediate associations between EAA and PHV, while SAT explained 8.4% of the association. Boys with higher EAA had lower total testosterone (β − 12.03, p = 0.0014), but associations between EAA and other sex steroids were not significant, and EAA was not associated with sex steroid levels in girls. We conclude that EAA did not have strong associations with either age at onset of puberty or pubertal growth speed, although associations with growth speed were statistically significant. Studies with larger sample sizes are needed to confirm this pattern of associations.
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- 2024
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105. Outpatient follow-up of tumour diseases through video-based value-oriented behavioural activation (ViVA): study protocol for a randomised controlled trial
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Maren Reder, Christine Hofheinz, Lena Melzner, Gabriele Prinz, and Christoph Kröger
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Value-oriented behavioural activation ,Psycho-oncological aftercare ,Oncological patients ,Psychological distress ,Covariate-adaptive randomisation ,Video-based treatment ,Medicine (General) ,R5-920 - Abstract
Abstract Background In Germany, approximately half a million people are diagnosed with cancer annually; this can be traumatic and lead to depression, anxiety, and adjustment disorders necessitating psycho-oncological intervention. Value-oriented behavioural activation, adopted from depression psychotherapy, aims to provide structured support to help patients adjust their personal values, goals, and activities within the context of their changed life situation. This trial aims to evaluate the effectiveness of video-based value-oriented behavioural activation against German S3-Guideline-compliant aftercare for cancer patients dealing with psychological distress. Methods This trial will use covariate-adaptive randomisation according to gender and type of tumour disease to assign participants to one of two study arms (value-oriented behavioural activation consisting of 12 manualised follow-up sessions delivered via video consultation vs. S3-Guideline-compliant aftercare comprising three supportive talks). Psychological strain, psychosocial distress, quality of life, work-related outcomes, fear of cancer recurrence, goal adjustment, satisfaction with the consultant-participant relationship, and rumination will be measured at baseline, twice during treatment, posttreatment, and at the 6-month follow-up. The target sample of 146 tumour patients experiencing high psychosocial distress will be recruited at the Rehazentrum Oberharz, Germany. Discussion This trial aims to test the effectiveness of value-oriented behavioural activation in aftercare for tumour patients, focusing on its capacity to reduce distress and the potential for long-term effects evaluated through a 6-month follow-up. The study’s possible challenges include enrolling a sufficient sample and ensuring adherence to treatment, mitigated through in-person recruitment and rigorous training of staff. If successful, the results will be of high public health relevance, especially for psychotherapeutic care in rural areas and among patients with limited mobility considering the video-based approach of the trial. Trial registration This study was registered at the German Clinical Trials Register: DRKS00031900 on Sep 19, 2023.
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- 2024
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106. Tension Band Wiring Olecranon Process Fracture Using Polyethylene Sutures and Percutaneous Pins
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Barbara Minkowitz, Christine Ho, Jennifer Ristic, and Allison Davanzo
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A 14-year-old male presents with right elbow injury from a fall during soccer. Physical exam shows decreased range of motion, swelling, deformity and tenderness at the olecranon. X-rays reveal 18 mm displaced fracture of the olecranon process. Open reduction internal fixation of the elbow was performed using number 2 polyethylene suture and percutaneous k-wires. This avoids reoperation to remove hardware without compromising quality of reduction. This was first described in 2006 by Gortzak et al. and a similar technique is demonstrated here through audiovisual aid.
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- 2022
107. A simple and effective 1D-element discrete-based method for computational bone remodeling
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Miguel Cerrolaza, Diego Quexada-Rodríguez, Marie Christine Ho-Ba-Tho, M.A Velasco, Diego Alexander Garzón-Alvarado, Carlos Duque-Daza, Kalenia Márquez-Flórez, Olfa Trabelsi, Salah Ramtani, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. GMNE - Grup de Mètodes Numèrics en Enginyeria, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Facultad de Ingenieria, Universidad Central de Venezuela (UCV), Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), and Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Nord
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Trabecular bone ,Computer science ,0206 medical engineering ,Finite Element Analysis ,Biomedical Engineering ,Bioengineering ,Bone architecture ,02 engineering and technology ,Bone and Bones ,Bone remodeling ,Topological optimization ,03 medical and health sciences ,0302 clinical medicine ,Simple (abstract algebra) ,Bones--Mechanical properties--Mathematical models ,Computer Simulation ,Bone mechanics ,Femur ,Enginyeria biomèdica [Àrees temàtiques de la UPC] ,Finite element analysis ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,030229 sport sciences ,General Medicine ,020601 biomedical engineering ,Finite element method ,Computer Science Applications ,Human-Computer Interaction ,Ossos -- Propietats mecàniques -- Models matemàtics ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Bone Remodeling ,Element (category theory) ,Algorithms ,Biomedical engineering - Abstract
This is an Accepted Manuscript of an article published by Taylor & Francis Group in Computer Methods in Biomechanics and Biomedical Engineering on 2022, available online at: http://www.tandfonline.com/10.1080/10255842.2021.1943370. In-silico models applied to bone remodeling are widely used to investigate bone mechanics, bone diseases, bone-implant interactions, and also the effect of treatments of bone pathologies. This paper proposes a new methodology to solve the bone remodeling problem using one-dimensional (1D) elements to discretize trabecular structures more efficiently for 2D and 3D domains. An Euler integration scheme is coupled with the momentum equations to obtain the evolution of material density at each step. For the simulations, the equations were solved by using the finite element method, and two benchmark tests were solved varying mesh parameters. Proximal femur and calcaneus bone were selected as study cases given the vast research available on the topology of these bones, and compared with the anatomical features of trabecular bone reported in the literature. The presented methodology has proven to be efficient in optimizing topologies of lattice structures; It can predict the trend of formation patterns of the main trabecular groups from two different cancellous bones (femur and calcaneus) using domains set up by discrete elements as a starting point. Preliminary results confirm that the proposed approach is suitable and useful in bone remodeling problems leading to a considerable computational cost reduction. Characteristics similar to those encountered in topological optimization (TO) algorithms were identified in the benchmark tests as well, showing the viability of the proposed approach in other applications such as bio-inspired design.
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- 2021
108. Enhanced facial expression recognition using 3D point sets and geometric deep learning
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Tien Tuan Dao, Marie Christine Ho Ba Tho, Duc-Phong Nguyen, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mécanique, Multiphysique, Multiéchelle - UMR 9013 (LaMcube), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Université de technologie de Compiègne, CNRS, Biomechanics and Bioengineering, Centre de recherche Royallieu, CS 60 319 - 60 203, Compiègne Cedex, France
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Feature engineering ,Computer science ,media_common.quotation_subject ,[SDV]Life Sciences [q-bio] ,Emotions ,Happiness ,Biomedical Engineering ,Point cloud ,02 engineering and technology ,[SPI]Engineering Sciences [physics] ,Deep Learning ,0202 electrical engineering, electronic engineering, information engineering ,Humans ,ComputingMilieux_MISCELLANEOUS ,media_common ,Facial expression ,business.industry ,Deep learning ,Confusion matrix ,020207 software engineering ,Pattern recognition ,Computer Science Applications ,Facial Expression ,Sadness ,Surprise ,Face (geometry) ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,Facial Recognition - Abstract
Facial expression recognition plays an essential role in human conversation and human-computer interaction. Previous research studies have recognized facial expressions mainly based on 2D image processing requiring sensitive feature engineering and conventional machine learning approaches. The purpose of the present study was to recognize facial expressions by applying a new class of deep learning called geometric deep learning directly on 3D point cloud data. Two databases (Bosphorus and SIAT-3DFE) were used. The Bosphorus database includes sixty-five subjects with seven basic expressions (i.e., anger, disgust, fearness, happiness, sadness, surprise, and neutral). The SIAT-3DFE database has 150 subjects and 4 basic facial expressions (neutral, happiness, sadness, and surprise). First, preprocessing procedures such as face center cropping, data augmentation, and point cloud denoising were applied on 3D face scans. Then, a geometric deep learning model called PointNet++ was applied. A hyperparameter tuning process was performed to find the optimal model parameters. Finally, the developed model was evaluated using the recognition rate and confusion matrix. The facial expression recognition accuracy on the Bosphorus database was 69.01% for 7 expressions and could reach 85.85% when recognizing five specific expressions (anger, disgust, happiness, surprise, and neutral). The recognition rate was 78.70% with the SIAT-3DFE database. The present study suggested that 3D point cloud could be directly processed for facial expression recognition by using geometric deep learning approach. In perspectives, the developed model will be applied for facial palsy patients to guide and optimize the functional rehabilitation program.
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- 2021
109. Traumatic Physeal Arrests at the Wrist
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Laura Bellaire, Carley Vuillermin, Suzanne Steinman, Walter Truong, Donald Bae, C. Douglas Wallace, and Christine Ho
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Fractures involving the physes of the distal forearm are exceedingly common in children, representing upwards of 1/3 of all pediatric fractures. These injuries are often amenable to closed treatment, but physeal injury can lead to premature arrest and significant related long-term sequela. Common practice guidelines have not been established amongst the pediatric orthopaedic community for radiographic monitoring, need for 3-dimensional imaging, and treatment algorithms in these injuries. This review seeks to outline the literature and share the perspective and methods of a panel of leading pediatric upper extremity experts in hopes of providing a framework for better understanding these injuries and treating their growth-related sequelae.
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- 2021
110. Deadlier road accidents? Traffic safety regulations and heterogeneous motorists’ behavior
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Madhav Shrihari Aney and Christine Ho
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Economics and Econometrics ,Road traffic safety ,Level data ,05 social sciences ,Personal injury ,Urban Studies ,Transport engineering ,Incentive ,SAFER ,0502 economics and business ,Business ,050207 economics ,human activities ,050205 econometrics - Abstract
In 2003, China enacted the Road Traffic Safety Law in an attempt to promote traffic safety. We employ a difference-in-differences strategy on province level data, where fire accidents are used as a control group for road accidents, to estimate the effects of the law on road accidents and casualties. Our findings suggest that while the law was successful in decreasing the number of accidents and casualties, the ratio of deaths to accidents and injuries to accidents increased. Exploring the potential channels, we find no evidence that “hit-and-kill” incentives, that is, incentives for motorists to kill the pedestrians that they hit due to China's peculiar personal injury compensation rules, drive the increase in death to accident ratio. We show that an increase in the severity of accidents could, in fact, be consistent with a model where all motorists drive more carefully after the reform, but have heterogeneous responses such that the decrease in accident probability is larger for safer than for riskier drivers.
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- 2019
111. Immune cell differences between patients in different stages of monoclonal plasma cell disorders
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Christine Ho, Paul K. Wallace, Kristopher Attwood, Sarah Parker, Hemn Mohammadpour, Megan Herr, George Chen, Joseph Tario, Philip L. McCarthy, and Jens Hillengass
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Cancer Research ,Oncology - Abstract
8065 Background: Multiple myeloma (MM) is an incurable plasma cell malignancy. Precursor conditions include monoclonal gammopathy of unknown significance (MGUS) and smoldering multiple myeloma (SMM). Immune surveillance is paramount for keeping the malignancy in check, whereas a dysfunctional immune system is suspected to promote disease progression. Methods: We performed flow cytometric immune panel analyses including T-cell, B-cell, natural killer (NK) cell and dendritic cell (DC) subsets in MGUS, SMM, and MM patients between 2018-2021. Immune panels were analyzed on fresh peripheral blood samples drawn at diagnosis. The patient population were MGUS (n=28), SMM (n=19) and MM (n=94). Samples from MGUS and SMM patients were combined into a single group (asymptomatic) and were compared to MM patients (symptomatic). Lymphocytes were identified by CD45+ expression resolving against side-scattered light on a bivariate plot. B cell and NK cell antigen expression profiles were assessed from this lymphocyte population. T cell subsets were further determined by CD3+. The percent gated for each marker was summarized by cohort using the appropriate descriptive statistics and compared using the Mann-Whitney U exact test. Analyses were performed in SAS v9.4 (Cary, NC) using a two-sided α=0.05. Results: Compared to MGUS/SMM patients, MM patients had a significant lower proportion of naive B cells, NK cells, and cytolytic NK cells, and a significant higher proportion of cytolytic T cells at diagnosis (Table). Consistent with prior studies, we demonstrated an increase in exhaustion markers. There was a trend toward a higher population of CD8+ exhausted T cells in MM patients compared to MGUS/SMM patients. Since the follow up for this study was short, survival data is not mature. Conclusions: This study demonstrates the immune imbalance that occurs between myeloma precursor conditions and MM. There is a shift in certain cell subsets in the immune microenvironment that alters tumor immunosurveillance and tumor cell killing favoring disease progression. In data not shown, we are currently analyzing the bone marrow microenvironment and its relation to disease progression. Follow up studies could assess if therapeutic intervention could reverse the imbalance, restore homeostatic equilibrium with the goal of controlling disease long-term. [Table: see text]
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- 2022
112. Towards effective screening for paternal perinatal mental illness: a meta-review of instruments and research gaps
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Philipp Schöch, Laura Hölzle, Astrid Lampe, Christine Hörtnagl, Ingrid Zechmeister-Koss, Anna Buchheim, and Jean Lillian Paul
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paternal perinatal depression ,paternal mental health ,perinatal ,depression ,anxiety ,fathers ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundPaternal perinatal mental illness (PPMI), which affects around one in 10 fathers, is under-recognised despite increasing awareness of men’s mental health in the perinatal period. Social stigma and men’s reluctance to seek help exacerbate this gap. Neglecting the mental health needs of new fathers not only puts them at increased risk for mental illness themselves, but also has a profound and long-lasting impact on their families, children and their own self-esteem as they navigate their new role in the family dynamic.ObjectiveThis meta-review systematically identifies instruments assessing PPMI symptoms, evaluates their psychometric properties and applicability, presents key findings from studies using these tools, and identifies gaps and limitations in the literature on PPMI symptom assessment.MethodsA systematic literature review was conducted using search strategies applied to PubMed, PsycNet APA, Cochrane, and Web of Science, supplemented by hand searches. Relevant information was extracted from each included study. Extracted data were analysed narratively to address the research questions.ResultsFindings identified limitations and gaps in current screening practices. While the Edinburgh Postnatal Depression Scale (EPDS) is the most widely used screening tool for both fathers and mothers, it inadequately captures atypical depressive symptoms in men. Cutoff scores lack consensus, and instrument sensitivity varies significantly due to cultural and sociodemographic factors. A number of other screening tools have been identified, most of which are more general and not specifically designed for perinatal mental health.ConclusionThis meta-review broadens perspectives on PPMI screening instruments, highlighting key themes, patterns, and differences across the included reviews. While a variety of screening tools are used, the review underscores the necessity for tools specifically tailored to fathers during the perinatal period.
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- 2024
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113. Identifying and synthesizing components of perinatal mental health peer support – a systematic review
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Laura Hölzle, Philipp Schöch, Christine Hörtnagl, Anna Buchheim, Astrid Lampe, Ingrid Zechmeister-Koss, and Jean Lillian Paul
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peer support ,social support ,perinatal mental health ,lived experience ,parental mental illness ,Psychiatry ,RC435-571 - Abstract
BackgroundBecoming a parent, while often perceived as a joyous event, can also be a vulnerable life transition, with approximately one in five mothers experiencing perinatal mental illness. Peer support is recommended for its preventive and therapeutic benefits. However, relevant program components of perinatal mental health peer support remain to be identified.ObjectivesThis review aims to (1) identify peer support programs in perinatal mental health through existing reviews and to (2) synthesize the components of these programs.MethodsA systematic literature review guided by PRISMA was conducted searching four databases, supplemented by hand searches. The Template for Intervention Description and Replication (TIDieR) checklist facilitated the systematic extraction and synthesis of program components.ResultsEleven peer support programs were identified from three reviews, largely conducted in English-speaking countries. The identified reviews highlight the benefits of peer support in perinatal mental health. Key components of individual programs were contextual background, materials, provider training and support, delivery modes and locations, and evaluation. Sharing lived experience and providing flexible support were central to all programs.ConclusionAspects of flexibility, authenticity and the challenges of program evaluation in peer support must be considered. Findings can now inform future planning and implementation efforts of peer support programs in periantal mental health.
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- 2024
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114. A New Multi-Sensor Fusion Scheme to Improve the Accuracy of Knee Flexion Kinematics for Functional Rehabilitation Movements.
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Halim Tannous, Dan Istrate, Aziz Benlarbi-Delaï, Julien Sarrazin, Didier Gamet, Marie Christine Ho Ba Tho, and Tien-Tuan Dao
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- 2016
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115. A polygenic score associated with fracture risk in breast cancer patients treated with aromatase inhibitors
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Christine Hook, Udit Chatterjee, Haiyang Sheng, Qianqian Zhu, Timothy Robinson, Janise M. Roh, Cecile A. Laurent, Catherine Lee, Jennifer Delmerico, Joan C. Lo, Christine B. Ambrosone, Lawrence H. Kushi, Marilyn L. Kwan, and Song Yao
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Identifying women at high risk of osteoporotic fracture from aromatase inhibitor (AI) therapy for breast cancer is largely based on known risk factors for healthy postmenopausal women, which might not accurately reflect the risk in breast cancer patients post-AI therapy. To determine whether a polygenic score associated with fracture in healthy women is also significant in women treated with AIs for breast cancer, we used data from a prospective observational cohort of 2152 women diagnosed with hormonal receptor positive breast cancer treated with AIs as the initial endocrine therapy and examined a polygenic score of heel quantitative ultrasound speed of sound (gSOS) in relation to incident osteoporotic fracture after AI therapy during a median 6.1 years of follow up after AI initiation. In multivariable models, patients with the second and third highest tertiles (T) versus the lowest tertile of gSOS had significantly lower risk of fracture (T2: adjusted HR = 0.61, 95% CI: 0.46-0.80; T3: adjusted HR = 0.53, 95% CI: 0.40-0.70). The lower risk of fracture in patients with the highest tertile of gSOS remained significant after further adjustment for BMD at the hip (T3: adjusted HR = 0.62, 95% CI: 0.42-0.91). In conclusion, our analysis showed gSOS as a novel genetic predictor for fracture risk independent of BMD among breast cancer patients treated with AIs. Future studies are warranted to evaluate the performance of incorporating gSOS in prediction models for the risk of AI-related fracture in breast cancer patients.
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- 2024
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116. Association between IGF-1 and IGFBPs in Blood and Follicular Fluid in Dairy Cows Under Field Conditions
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Christina Schiffers, Idil Serbetci, Kirsten Mense, Ana Kassens, Hanna Grothmann, Matthias Sommer, Christine Hoeflich, Andreas Hoeflich, Heinrich Bollwein, and Marion Schmicke
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IGF-1 ,IGFBP ,somatotropic axis ,dairy cow ,cattle ,fertility ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
Insulin-like growth factor 1 (IGF-1) regulates dairy cow reproduction, while the paracrine IGF system locally influences fertility. In both systems, IGF-1 bioactivity is regulated through binding proteins (IGFBPs) inhibiting IGF-1 binding to its receptor (IGF1R). This study aimed to investigate a possible transfer between this endocrine and paracrine system. Therefore, blood and follicular fluid (FF) from postpartum dairy cows were analysed for ß-hydroxybutyrate (BHB), IGF-1, IGFBP-2, -3, -4, -5, and an IGFBP fragment in two study parts. The mRNA expression of IGFBP-2, IGFBP-4, IGF1R, and the pregnancy-associated plasma protein A (PAPP-A) in granulosa cells was measured. The results showed correlations between plasma and FF for IGF-1 (r = 0.57, p < 0.001) and IGFBP-2 (r = −0.57, p < 0.05). Blood BHB negatively correlated with IGF-1 in blood and FF and IGFBP-3, -5 and total IGFBP in blood (IGF-1 plasma: r = −0.26, p < 0.05; FF: r = −0.35, p < 0.05; IGFBP-3: r = −0.64, p = 0.006; IGFBP-5: r = −0.49, p < 0.05; total IGFBP: r = −0.52, p < 0.05). A negative correlation was found between IGFBP-2 expression and IGF-1 concentration in FF (r = −0.97, p = 0.001), while an IGFBP fragment positively correlated with IGF1R-mRNA in FF (r = 0.82, p = 0.042). These findings suggest a transfer and local regulation between the somatotropic axis and the follicular IGF system, linking the metabolic status with local effects on dairy cow fertility.
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- 2024
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117. The use of multi-pronged screening strategy to understand the epidemiology of carbapenemase-producing Enterobacteriaceae in Hong Kong: transition from epidemic to endemic setting
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Shuk- Ching, Wong, Veronica Wing- Man, Chan, Germaine Kit-Ming, Lam, Christine Ho-Yan, AuYeung, Elaine Yin-Ling, Leung, Simon Yung-Chun, So, Jonathan Hon-Kwan, Chen, Siddharth, Sridhar, Anthony Raymond, Tam, Ivan Fan-Ngai, Hung, Pak- Leung, Ho, Kwok- Yung, Yuen, and Vincent Chi-Chung, Cheng
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Adult ,Aged, 80 and over ,Diagnostic Screening Programs ,Male ,Infection Control ,Adolescent ,Endemic Diseases ,Enterobacteriaceae Infections ,Infant ,Middle Aged ,beta-Lactamases ,Feces ,Young Adult ,Carbapenem-Resistant Enterobacteriaceae ,Bacterial Proteins ,Child, Preschool ,Animals ,Hong Kong ,Humans ,Female ,Child ,Epidemics ,Aged - Abstract
A multi-pronged carbapenemase-producing Enterobacteriaceae (CPE) screening strategy was implemented in Hong Kong West healthcare network. Of 199,192 fecal specimens from 77,194 patients screening from 1 July 2011 to 30 June 2019, the incidence of CPE per 1000 patient admission significantly increased from 0.01 (2012) to 1.9 (2018) (p0.01). With appropriate infection control measures, the incidence of nosocomial CPE per 1000 CPE colonization day decreased from 22.34 (2014) to 10.65 (2018) (p=0.0094). Exposure to wet market for purchasing raw pork (p=0.007), beef (p=0.017), chicken (p=0.026), and vegetable (p=0.034) for3 times per week significantly associated with community acquisition of CPE. Strategic CPE control measures should be implemented in both the hospital and the community.
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- 2020
118. Kinect-driven Patient-specific Head, Skull, and Muscle Network Modelling for Facial Palsy Patients
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Tan-Nhu Nguyen, Stéphanie Dakpé, Tien Tuan Dao, Marie Christine Ho Ba Tho, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Department of maxillo-facial surgery, CHU AMIENS-PICARDIE, Amiens, France, CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 (CHIMERE), Université de Picardie Jules Verne (UPJV), Laboratoire de Mécanique, Multiphysique, Multiéchelle - UMR 9013 (LaMcube), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Université de technologie de Compiègne, CNRS, Biomechanics and Bioengineering, Centre de recherche Royallieu, CS 60 319 - 60 203, Compiègne Cedex, France
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Male ,Head (linguistics) ,Computer science ,[SDV]Life Sciences [q-bio] ,Facial Paralysis ,Health Informatics ,Strain (injury) ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,[SPI]Engineering Sciences [physics] ,0302 clinical medicine ,medicine ,Muscle attachment ,Humans ,Computer vision ,ComputingMilieux_MISCELLANEOUS ,Palsy ,business.industry ,Muscles ,Skull ,medicine.disease ,Vertex (anatomy) ,Facial paralysis ,Computer Science Applications ,Facial muscles ,medicine.anatomical_structure ,Face ,Female ,Artificial intelligence ,business ,Head ,030217 neurology & neurosurgery ,Software - Abstract
Background and Objective Facial palsy negatively affects both professional and personal life qualities of involved patients. Classical facial rehabilitation strategies can recover facial mimics into their normal and symmetrical movements and appearances. However, there is a lack of objective, quantitative, and in-vivo facial texture and muscle activation bio-feedbacks for personalizing rehabilitation programs and diagnosing recovering progresses. Consequently, this study proposed a novel patient-specific modelling method for generating a full patient specific head model from a visual sensor and then computing the facial texture and muscle activation in real-time for further clinical decision making. Methods The modeling workflow includes (1) Kinect-to-head, (2) head-to-skull, and (3) muscle network definition & generation processes. In the Kinect-to-head process, subject-specific data acquired from a new user in neutral mimic were used for generating his/her geometrical head model with facial texture. In particular, a template head model was deformed to optimally fit with high-definition facial points acquired by the Kinect sensor. Moreover, the facial texture was also merged from his/her facial images in left, right, and center points of view. In the head-to-skull process, a generic skull model was deformed so that its shape was statistically fitted with his/her geometrical head model. In the muscle network definition & generation process, a muscle network was defined from the head and skull models for computing muscle strains during facial movements. Muscle insertion points and muscle attachment points were defined as vertex positions on the head model and the skull model respectively based on the standard facial anatomy. Three healthy subjects and two facial palsy patients were selected for validating the proposed method. In neutral positions, magnetic resonance imaging (MRI)-based head and skull models were compared with Kinect-based head and skull models. In mimic positions, infrared depth-based head models in smiling and [u]-pronouncing mimics were compared with appropriate animated Kinect-driven head models. The Hausdorff distance metric was used for these comparisons. Moreover, computed muscle lengths and strains in the tested facial mimics were validated with reported values in literature. Results With the current hardware configuration, the patient-specific head model with skull and muscle network could be fast generated within 17.16±0.37s and animated in real-time with the framerate of 40 fps. In neutral positions, the best mean error was 1.91 mm for the head models and 3.21 mm for the skull models. On facial regions, the best mean errors were 1.53 mm and 2.82 mm for head and skull models respectively. On muscle insertion/attachment point regions, the best mean errors were 1.09 mm and 2.16 mm for head and skull models respectively. In mimic positions, these errors were 2.02 mm in smiling mimics and 2.00 mm in [u]-pronouncing mimics for the head models on facial regions. All above error values were computed on a one-time validation procedure. Facial muscles exhibited muscle shortening and muscle elongating for smiling and pronunciation of sound [u] respectively. Extracted muscle features (i.e. muscle length and strain) are in agreement with experimental and literature data. Conclusions This study proposed a novel modeling method for fast generating and animating patient-specific biomechanical head model with facial texture and muscle activation bio-feedbacks. The Kinect-driven muscle strains could be applied for further real-time muscle-oriented facial paralysis grading and other facial analysis applications.
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- 2020
119. New Zealand National Audit of Outpatient Inflammatory Bowel Disease Standards of Care
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Robert, Hackett, Richard, Gearry, Christine, Ho, Andrew, McCombie, Megan, Mackay, Karen, Murdoch, Kirsten, Rosser, Nideen, Visesio, and Stephen, Inns
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inflammatory bowel disease ,standards ,specialist nursing ,digestive system diseases ,Original Research ,New Zealand - Abstract
Aim This study audits the delivery and standards of New Zealand (NZ) inflammatory bowel disease (IBD) care against international standards, with emphasis on the IBD nursing role. Methods Utilising international standards in IBD care, a 3 phase national multicentre survey study was performed between 2015 and 2019. We 1) evaluated the current role and practices of IBD nurses, 2) evaluated IBD service provision and identified areas for improvement, and 3) audited key aspects of IBD patient care, directly comparing nurse-led and doctor-led outpatient clinics. Results The median duration spent in an IBD nursing role was 21 months (range 2 to 120 months) with the majority (12/15) performing two or more nursing roles. The median IBD nurse full-time equivalent (FTE) was 0.8 (range 0.2 to 1.25). The average number of hours spent undertaking IBD nursing tasks was 22.2 – a 6.8-hour shortfall compared to rostered hours. No service had a per capita IBD multidisciplinary team (MDT) FTE which met international standards. Just under two-thirds (62.5%) of departments held a regular MDT meeting. All responding services could be contacted directly by IBD patients and respond within 48 hours of contact. During 492 doctor-led and 196 nurse-led scheduled outpatient clinic visits, nurses were significantly more likely to document weight, smoking status and organise appropriate colonoscopic surveillance than doctors. Conclusion Multiple nursing job roles resulted in rostered hours being insufficient to complete IBD specific tasks. IBD FTE did not meet international standards. The IBD care was patient-centred, encouraging direct contact from patients with prompt response. IBD nurses in NZ provide high-quality outpatient care when measured against auditable standards. As the IBD nursing role continues to develop, following the implementation of an educational framework and education programme, an increase in numbers is required in order to achieve the recommended minimum FTE per 250 000 population.
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- 2020
120. A Systematic Review of Real-Time Medical Simulations with Soft-Tissue Deformation: Computational Approaches, Interaction Devices, System Architectures, and Clinical Validations
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Tien Tuan Dao, Tan-Nhu Nguyen, Marie-Christine Ho Ba Tho, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), and Sorbonne Université (SU)
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medicine.medical_specialty ,QH301-705.5 ,Computer science ,Computation ,030303 biophysics ,Constraint (computer-aided design) ,Biomedical Engineering ,Soft tissue deformation ,Medicine (miscellaneous) ,Bioengineering ,Review Article ,02 engineering and technology ,03 medical and health sciences ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Review process ,Biology (General) ,[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,Protocol (science) ,0303 health sciences ,Medical simulation ,Task (computing) ,Human interface device ,Systems engineering ,020201 artificial intelligence & image processing ,TP248.13-248.65 ,Biotechnology - Abstract
International audience; Simulating deformations of soft tissues is a complex engineering task, and it is even more difficult when facing the constraint between computation speed and system accuracy. However, literature lacks of a holistic review of all necessary aspects (computational approaches, interaction devices, system architectures, and clinical validations) for developing an effective system of soft-tissue simulations. This paper summarizes and analyses recent achievements of resolving these issues to estimate general trends and weakness for future developments. A systematic review process was conducted using the PRISMA protocol with three reliable scientific search engines (ScienceDirect, PubMed, and IEEE). Fifty-five relevant papers were finally selected and included into the review process, and a quality assessment procedure was also performed on them. The computational approaches were categorized into mesh, meshfree, and hybrid approaches. The interaction devices concerned about combination between virtual surgical instruments and force-feedback devices, 3D scanners, biomechanical sensors, human interface devices, 3D viewers, and 2D/3D optical cameras. System architectures were analysed based on the concepts of system execution schemes and system frameworks. In particular, system execution schemes included distribution-based, multithread-based, and multimodel-based executions. System frameworks are grouped into the input and output interaction frameworks, the graphic interaction frameworks, the modelling frameworks, and the hybrid frameworks. Clinical validation procedures are ordered as three levels: geometrical validation, model behavior validation, and user acceptability/safety validation. The present review paper provides useful information to characterize how real-time medical simulation systems with soft-tissue deformations have been developed. By clearly analysing advantages and drawbacks in each system development aspect, this review can be used as a reference guideline for developing systems of soft-tissue simulations.
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- 2020
121. Real-time computer vision system for tracking simultaneously subject-specific rigid head and non-rigid facial mimic movements using a contactless sensor and system of systems approach
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Stéphanie Dakpé, Marie Christine Ho Ba Tho, Tan-Nhu Nguyen, Tien Tuan Dao, Ho Chi Minh city University of Technology and Education, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), CHU Amiens-Picardie, CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 (CHIMERE), Université de Picardie Jules Verne (UPJV), Laboratoire de Mécanique, Multiphysique, Multiéchelle - UMR 9013 (LaMcube), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
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System of systems ,Systems Analysis ,Computer science ,business.industry ,Head (linguistics) ,[SDV]Life Sciences [q-bio] ,Health Informatics ,Animation ,Tracking (particle physics) ,030218 nuclear medicine & medical imaging ,Computer Science Applications ,03 medical and health sciences ,0302 clinical medicine ,Imaging, Three-Dimensional ,Artificial Intelligence ,Head Movements ,Humans ,Computer vision ,Artificial intelligence ,business ,030217 neurology & neurosurgery ,Software ,Graphical user interface ,ComputingMethodologies_COMPUTERGRAPHICS - Abstract
International audience; Background and Objective: Head and facial mimic animations play important roles in various fields such as human-machine interactions, internet communications, multimedia applications, and facial mimic analysis. Numerous studies have been trying to simulate these animations. However, they hardly achieved all requirements of full rigid head and non-rigid facial mimic animations in a subject-specific manner with real-time framerates. Consequently, this present study aimed to develop a real-time computer vision system for tracking simultaneously rigid head and non-rigid facial mimic movements. Methods: Our system was developed using the system of systems approach. A data acquisition sub-system was implemented using a contactless Kinect sensor. A subject-specific model generation sub-system was designed to create the geometrical model from the Kinect sensor without texture information. A subject-specific texture generation sub-system was designed for enhancing the reality of the generated model with texture information. A head animation sub-system with graphical user interfaces was also developed. Model accuracy and system performances were analyzed. Results: The comparison with MRI-based model shows a very good accuracy level (distance deviation of similar to 1 mm in neutral position and an error range of [2-3 mm] for different facial mimic positions) for the generated model from our system. Moreover, the system speed can be optimized to reach a high framerate (up to 60 fps) during different head and facial mimic animations. Conclusions: This study presents a novel computer vision system for tracking simultaneously subject-specific rigid head and non-rigid facial mimic movements in real time. In perspectives, serious game technology will be integrated into this system towards a full computer-aided decision support system for facial rehabilitation. (C) 2020 Elsevier B.V. All rights reserved.
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- 2020
122. Hb Agrigente affects haemoglobin A1c laboratory methods: a case report
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Julie Sherfan, Susan Oliver, Christine Ho, and David R. Sullivan
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- 2022
123. Influence of strain rate on the mechanical behavior of cortical bone interstitial lamellae at the micrometer scale
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Vanleene, Maximilien, Mazeran, Pierre-Emmanuel, and Tho, Marie-Christine Ho Ba
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- 2006
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124. 10. The Struggle for Civic Social Capital in West Indian Churches
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Teruyuki Tsuji, Christine Ho, and Alex Stepick
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- 2019
125. Child’s gender, parental monetary investments and care of elderly parents in China
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Christine Ho
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Value (ethics) ,Economics and Econometrics ,Longitudinal study ,Activities of daily living ,Opportunity cost ,Courtesy ,050204 development studies ,05 social sciences ,humanities ,0502 economics and business ,Economics ,Demographic economics ,050207 economics ,China ,Parental investment ,health care economics and organizations ,Social Sciences (miscellaneous) ,Reciprocity (cultural anthropology) - Abstract
This study analyzes whether parental monetary investments in children stimulate support from sons and daughters. Using data from the China Health and Retirement Longitudinal Study, I find that parents invested twice more in sons than in daughters in terms of college education spending and marriage gifts value. Conversely, higher parental monetary investments are associated with higher increases in support from daughters than from sons in terms of best living proximity and most help with activities of daily living. Parental monetary investments in sons’ college education are positively associated with sons’ income and negatively associated with sons’ instrumental support, suggesting that such investments potentially generate higher opportunity costs of time for sons. Meanwhile, parental monetary investments in daughters’ marriage are positively associated with daughters’ instrumental support, which may occur through an income effect or through reciprocity from daughters. There is no conclusive evidence that parental monetary investments stimulate monetary and in-kind transfers from children, suggesting that material support possibly occurs out of social norm courtesy.
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- 2018
126. Detailed Multi-Dimensional Assessment of Fatigue in Inflammatory Bowel Disease
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Rashid Al-Mandhari, Catherine E. Hobbs, Merrilee Williams, Michael Schultz, Hamish Osborne, Kristina Aluzaite, Christine Ho, and Marie-Michelle Sullivan
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Original Paper ,Crohn's disease ,medicine.medical_specialty ,business.industry ,Mental fatigue ,Gastroenterology ,Disease ,medicine.disease ,Inflammatory bowel disease ,Ulcerative colitis ,Quality of life ,Internal medicine ,Multi dimensional ,Medicine ,In patient ,business - Abstract
Background: Fatigue is a symptom commonly reported by patients with inflammatory bowel disease (IBD). Treating any underlying inflammation in active disease improves the health outcomes and decreases fatigue, but fatigue still persists in remission, negatively affecting patients’ quality of life and posing a challenge for the treating physician. The aim of this study was to describe the prevalence of fatigue in patients with IBD and investigate possible contributing factors. Methods: Recruited IBD patients from the Otago region in southern New Zealand were asked to complete demographic, physical activity (IPAQ) and fatigue questionnaires (Brief Fatigue Inventory, Multidimensional Fatigue Inventory). Disease activity and factors contributing to fatigue were assessed through self-reporting and laboratory biomarkers. Results: One hundred and thirteen of the contacted 469 IBD patients participated in the study. Depending on the questionnaire used, the prevalence of fatigue in IBD was high in remission (39.5–44.2%) but significantly higher (p < 0.001) in active disease (80.0–82.9%). Several factors such as age, disease duration, level of physical activity, gender and diet were found to be associated with increased fatigue and were attributed to either mental or physical fatigue categories. Multifactorial Fatigue Inventory provided insights into different types of fatigue, and revealed a significant mental fatigue component in both active and remission disease patients. Iron deficiency was not associated with fatigue levels. Conclusions: Fatigue in IBD is multi-faceted and highly prevalent in both active and remission IBD. Further investigations, addressing the complexity of the symptom and its reporting are needed.
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- 2018
127. Analysis of liver viscosity behavior as a function of multifrequency magnetic resonance elastography (MMRE) postprocessing
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Leclerc, Gwladys E., Charleux, Fabrice, Robert, Ludovic, Tho, Marie-Christine Ho Ba, Rhein, Colette, Latrive, Jean-Paul, and Bensamoun, Sabine F.
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- 2013
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128. TEACHER CANDIDATES PEER-ORIENTED TRIADS: TRANSFORMING PRACTICE THROUGH PEER ASSESSMENT DURING FIELD EXPERIENCE.
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Younghusband, Christine Ho and Koehn, Deborah
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STUDENT teachers ,TEACHER education ,UNIVERSITY faculty - Abstract
In 2018 a teacher education program at a small research university implemented three initiatives to improve the practicum experience for teacher candidates. This program evaluation focusses on one of three initiatives, specifically, peer-oriented triads during practicum. The faculty members used the Spiral of Inquiry (Kaser & Halbert, 2017) as a framework to guide the implementation and assess the viability of triads during practicum, and to assess their worthwhileness. Teacher candidates tended to feel isolated and judged after a practicum experience. The implementation and intention of triads was to provide teacher candidates with ongoing feedback, support, and learning opportunities with peers from their cohort during practicum. Triads, or groups of three, were an ideal group size for sense-making, problem-solving, and collaborating. The feedback provided at the end of the program during the Celebration of Learning was that triads were valued and were considered a safe place to learn. [ABSTRACT FROM AUTHOR]
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- 2022
129. Relationship between objectively measured physical activity and subclinical cardiovascular disease: a systematic review
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Chris T Longenecker, Aparna Narendrula, Ellen Brinza, Christine Horvat Davey, and Allison R Webel
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Medicine (General) ,R5-920 - Abstract
Introduction The association of physical activity (PA) with subclinical cardiovascular disease (CVD) is unclear. Clarifying this relationship may inform cardiovascular prevention strategies.Methods We performed a systematic review (CRD42021226089) using Medline, Embase, CINAHL and Cochrane (1 January 2000 to 1 September 2023). Studies published with adult populations exploring the relationship between objectively measured PA and subclinical CVD were included. Subclinical CVD was assessed using: ankle-brachial index (ABI); arterial stiffness; carotid artery disease; coronary artery atherosclerosis; endothelial function; and measures of cardiac structure and function. The Risk Of Bias In Non-randomised Studies - of Interventions (ROBINS-I) and Cochrane Risk of Bias tools were used for quality review.Results Of 68 included studies, most supported an inverse relationship between PA and subclinical CVD. Arterial stiffness was the most common outcome (n=40), and 33 studies suggested that less sedentary behaviour (SB), increased PA and/or higher intensity PA was associated with less arterial stiffness. Ten studies of carotid artery disease (total n=18), six of endothelial function (n=10), two of coronary artery disease (n=3) and all of ABI (n=6) suggested that PA or less SB is associated with less subclinical disease. Five studies assessing cardiac structure/function (n=6) suggested alterations in structure/function with PA.Conclusions PA reduces the risk of CVD events, and this systematic review demonstrates that some of the benefits may be mediated by an inverse association between PA and subclinical CVD. Interventions to increase PA are important for CVD prevention, so we provide a comprehensive overview of which surrogate outcome measures may be most useful to assess future CVD prevention interventions.PROSPERO registration number CRD42021226089.
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- 2024
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130. Ketamine for postoperative avoidance of depressive symptoms: the K-PASS feasibility randomised trial
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Bradley A. Fritz, Bethany R. Tellor Pennington, Catherine Dalton, Christine Horan, Ben J.A. Palanca, Julie A. Schweiger, Logan Griffin, Wilberforce Tumwesige, Jon T. Willie, and Nuri B. Farber
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clinical trial ,depression ,feasibility trial ,ketamine ,postoperative depression ,Anesthesiology ,RD78.3-87.3 - Abstract
Background: Surgical patients with previous depression frequently experience postoperative depressive symptoms. This study's objective was to determine the feasibility of a placebo-controlled trial testing the impact of a sustained ketamine infusion on postoperative depressive symptoms. Methods: This single-centre, triple-blind, placebo-controlled randomised clinical trial included adult patients with depression scheduled for inpatient surgery. After surgery, patients were randomly allocated to receive ketamine (0.5 mg kg−1 over 10 min followed by 0.3 mg kg−1 h−1 for 3 h) or an equal volume of normal saline. Depressive symptoms were measured using the Montgomery–Asberg Depression Rating Scale. On post-infusion day 1, participants guessed which intervention they received. Feasibility endpoints included the fraction of patients approached who were randomised, the fraction of randomised patients who completed the study infusion, and the fraction of scheduled depression assessments that were completed. Results: In total, 32 patients were allocated a treatment, including 31/101 patients approached after a protocol change (31%, 1.5 patients per week). The study infusion was completed without interruption in 30/32 patients (94%). In each group, 7/16 participants correctly guessed which intervention they received. Depression assessments were completed at 170/192 scheduled time points (89%). Between baseline and post-infusion day 4 (pre-specified time point of interest), median depressive symptoms decreased in both groups, with difference-in-differences of −1.00 point (95% confidence interval −3.23 to 1.73) with ketamine compared with placebo. However, the between-group difference did not persist at other time points. Conclusions: Patient recruitment, medication administration, and clinical outcome measurement appear to be highly feasible, with blinding maintained. A fully powered trial may be warranted. Clinical trial registration: NCT05233566.
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- 2024
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131. Absence of nosocomial influenza and respiratory syncytial virus infection in the coronavirus disease 2019 (COVID-19) era: Implication of universal masking in hospitals
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Wong, Shuk-Ching, primary, Lam, Germaine Kit-Ming, additional, AuYeung, Christine Ho-Yan, additional, Chan, Veronica Wing-Man, additional, Wong, Newton Lau-Dan, additional, So, Simon Yung-Chun, additional, Chen, Jonathan Hon-Kwan, additional, Hung, Ivan Fan-Ngai, additional, Chan, Jasper Fuk-Woo, additional, Yuen, Kwok-Yung, additional, and Cheng, Vincent Chi-Chung, additional
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- 2020
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132. Acylation of glycerolipids in mycobacteria
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Shiva Kumar Angala, Ana Carreras-Gonzalez, Emilie Huc-Claustre, Itxaso Anso, Devinder Kaur, Victoria Jones, Zuzana Palčeková, Juan M. Belardinelli, Célia de Sousa-d’Auria, Libin Shi, Nawel Slama, Christine Houssin, Annaïk Quémard, Michael McNeil, Marcelo E. Guerin, and Mary Jackson
- Subjects
Science - Abstract
Abstract We report on the existence of two phosphatidic acid biosynthetic pathways in mycobacteria, a classical one wherein the acylation of the sn-1 position of glycerol-3-phosphate (G3P) precedes that of sn-2 and another wherein acylations proceed in the reverse order. Two unique acyltransferases, PlsM and PlsB2, participate in both pathways and hold the key to the unusual positional distribution of acyl chains typifying mycobacterial glycerolipids wherein unsaturated substituents principally esterify position sn-1 and palmitoyl principally occupies position sn-2. While PlsM selectively transfers a palmitoyl chain to the sn-2 position of G3P and sn-1-lysophosphatidic acid (LPA), PlsB2 preferentially transfers a stearoyl or oleoyl chain to the sn-1 position of G3P and an oleyl chain to sn-2-LPA. PlsM is the first example of an sn-2 G3P acyltransferase outside the plant kingdom and PlsB2 the first example of a 2-acyl-G3P acyltransferase. Both enzymes are unique in their ability to catalyze acyl transfer to both G3P and LPA.
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- 2023
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133. Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
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Kayo Yukawa, Satomi Yamamoto-Mcguire, Louis Cafaro, Christine Hong, Fredrik Kamme, Tsuneya Ikezu, and Seiko Ikezu
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Alzheimer’s disease ,Tau ,TTBK1 ,Pathology ,Neurodegenerative ,Tauopathy ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau pathology evolves in Alzheimer’s disease (AD). The protein expression level of TTBK1 is elevated in the cortex brain tissues with AD patients compared to the control subjects. We therefore hypothesized that antisense oligonucleotide (ASO) based targeting Ttbk1 could prevent the accumulation of phosphorylated tau, thereby delaying the development of tau pathology in AD. Here we show that in vivo administration of ASO targeting mouse Ttbk1 (ASO-Ttbk1) specifically suppressed the expression of Ttbk1 without affecting Ttbk2 expression in the temporal cortex of PS19 tau transgenic mice. Central administration of ASO-Ttbk1 in PS19 mice significantly reduced the expression level of representative phosphor-tau epitopes relevant to AD at 8 weeks post-dose, including pT231, pT181, and pS396 in the sarkosyl soluble and insoluble fractions isolated from hippocampal tissues as determined by ELISA and pS422 in soluble fractions as determined by western blotting. Immunofluorescence demonstrated that ASO-Ttbk1 significantly reduced pS422 phosphorylated tau intensity in mossy fibers region of the dentate gyrus in PS19 mice. RNA-sequence analysis of the temporal cortex tissue revealed significant enrichment of interferon-gamma and complement pathways and increased expression of antigen presenting molecules (Cd86, Cd74, and H2-Aa) in PS19 mice treated with ASO-Ttbk1, suggesting its potential effect on microglial phenotype although neurotoxic effect was absent. These data suggest that TTBK1 is an attractive therapeutic target to suppress TTBK1 without compromising TTBK2 expression and pathological tau phosphorylation in the early stages of AD.
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- 2023
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134. Cerebrovascular Events in Older Patients With Patent Foramen Ovale: Current Status and Future Perspectives
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Julio I. Farjat-Pasos, Angel Chamorro, Sylvain Lanthier, Mathieu Robichaud, Siddhartha Mengi, Christine Houde, and Josep Rodés-Cabau
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patent foramen ovale ,cryptogenic stroke ,elderly population ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Patent foramen ovale (PFO) closure, along with medical therapy, has emerged as the therapeutic gold standard in younger (60 years) patients with a PFO-related cerebrovascular event, a complex group of patients who were mostly excluded from PFO closure clinical trials. Nevertheless, several studies have shown a higher prevalence of PFO among older patients with cryptogenic stroke, and its presence has been associated with an increased risk of recurrent events. Furthermore, older patients exhibit a higher prevalence of high-risk PFO anatomical features, present inherent age-related risk factors that might increase the risk of paradoxical embolism through a PFO, and have a higher incidence of ischemic events after a PFO-related event. Additionally, observational studies have shown the safety and preliminary efficacy of PFO closure in older PFO-related stroke patients. Yet, higher rates of recurrent cerebrovascular events and new-onset atrial fibrillation were observed in some studies among older patients compared to their younger counterparts. After careful case-by-case evaluation, including the assessment of hidden potential cardioembolic sources of a cryptogenic stroke other than PFO, transcatheter PFO closure might be a safe and effective therapeutic option for preventing recurrent thromboembolic events in patients >60 years with a high-risk PFO-associated stroke. Ongoing trials will provide important insights into the role of PFO closure in the elderly population.
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- 2023
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135. Using decision tree analysis to identify population groups at risk of subjective unmet need for assistance with activities of daily living
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Philipp Jaehn, Hella Fügemann, Kathrin Gödde, and Christine Holmberg
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Conditional inference trees ,Social care ,Vulnerable groups ,Resource allocation ,Unmet need for assistance ,Activities of daily living ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background Identifying predictors of subjective unmet need for assistance with activities of daily living (ADL) is necessary to allocate resources in social care effectively to the most vulnerable populations. In this study, we aimed at identifying population groups at risk of subjective unmet need for assistance with ADL and instrumental ADL (IADL) taking complex interaction patterns between multiple predictors into account. Methods We included participants aged 55 or older from the cross-sectional German Health Update Study (GEDA 2019/2020-EHIS). Subjective unmet need for assistance was defined as needing any help or more help with ADL (analysis 1) and IADL (analysis 2). Analysis 1 was restricted to participants indicating at least one limitation in ADL (N = 1,957). Similarly, analysis 2 was restricted to participants indicating at least one limitation in IADL (N = 3,801). Conditional inference trees with a Bonferroni-corrected type 1 error rate were used to build classification models of subjective unmet need for assistance with ADL and IADL, respectively. A total of 36 variables representing sociodemographics and impairments of body function were used as covariates for both analyses. In addition, the area under the receiver operating characteristics curve (AUC) was calculated for each decision tree. Results Depressive symptoms according to the PHQ-8 was the most important predictor of subjective unmet need for assistance with ADL. Further classifiers that were selected from the 36 independent variables were gender identity, employment status, severity of pain, marital status, and educational level according to ISCED-11. The AUC of this decision tree was 0.66. Similarly, depressive symptoms was the most important predictor of subjective unmet need for assistance with IADL. In this analysis, further classifiers were severity of pain, social support according to the Oslo-3 scale, self-reported prevalent asthma, and gender identity (AUC = 0.63). Conclusions Reporting depressive symptoms was the most important predictor of subjective unmet need for assistance among participants with limitations in ADL or IADL. Our findings do not allow conclusions on causal relationships. Predictive performance of the decision trees should be further investigated before conclusions for practice can be drawn.
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- 2023
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136. Multimodal Medical Imaging Fusion for Patient Specific Musculoskeletal Modeling of the Lumbar Spine System in Functional Posture
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Philippe Pouletaut, Aron Lazary, Marie Christine Ho Ba Tho, and Tien Tuan Dao
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medicine.medical_specialty ,business.industry ,0206 medical engineering ,Biomedical Engineering ,02 engineering and technology ,General Medicine ,Fascicle ,Sensor fusion ,020601 biomedical engineering ,Clinical decision support system ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Feature (computer vision) ,Medical imaging ,medicine ,Physical therapy ,Muscle attachment ,Sensitivity (control systems) ,Metric (unit) ,business ,030217 neurology & neurosurgery - Abstract
Current musculoskeletal modeling does not take the functionally initial standing posture of the lumbar spine system into consideration. This may lead to inaccurate simulation outcomes for clinical decision support. This present study aimed to develop a fusion process from multimodal medical images for developing, simulating, and assessing patient specific musculoskeletal model of the lumbar spine system in functional posture. Computed tomography (CT) and X-rays were acquired on a patient. A 3D/2D matching procedure was developed using feature-based approach to transform CT-based 3D geometries into standing posture. Then, a musculoskeletal model was developed including 7 segments, 18-DOF (degrees of freedom) and 126 muscle fascicles. Model evaluation was performed using X-ray data and curvature metric. Muscle force deviations were quantified for the comparison between image-based model and generic-scaled model as well as for the sensitivity of psoas major attachment point definition. Curvatures of the simulation outcomes fall within the range of X-ray data for extension posture. Difference was noted for flexed posture. The use of generic model leads to a deviation of 66% of the muscle forces according to the image-based model. A maximal relative deviation of 4% of the estimated psoas major fascicle force was found for the analysis of the sensitivity of muscle attachment point. This study proposed a useful data fusion process from multimodal medical images to create patient specific lumbar spine model in correct initial posture leading to perform accurate dynamic simulations. Moreover, this study suggested that image-based model needs to be developed for clinical decision making related to spinal disorders.
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- 2017
137. Pediatric Type II Supracondylar Humerus Fractures: Factors Associated with Successful Closed Reduction and Immobilization
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Patrick O. Ojeaga, Christine Ho, Henry Ellis, Charles Wyatt, Philip Wilson, and Marilyn Elliott
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Pediatrics, Perinatology and Child Health - Published
- 2020
138. Tuberculosis in Jails and Prisons: United States, 2002−2013
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Lauren A. Lambert, Lori R. Armstrong, Mark N. Lobato, Christine Ho, Anne Marie France, and Maryam B. Haddad
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Adult ,Male ,Tuberculosis ,Adolescent ,Article ,Annual incidence ,Justice statistics ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Tuberculosis diagnosis ,Environmental health ,Humans ,Mass Screening ,Medicine ,030212 general & internal medicine ,Young adult ,Tuberculosis incidence ,Mass screening ,030505 public health ,business.industry ,Incidence ,Prisoners ,Incidence (epidemiology) ,Public Health, Environmental and Occupational Health ,Middle Aged ,medicine.disease ,United States ,Population Surveillance ,Prisons ,Female ,0305 other medical science ,business ,Demography - Abstract
Objectives. To describe cases and estimate the annual incidence of tuberculosis in correctional facilities. Methods. We analyzed 2002 to 2013 National Tuberculosis Surveillance System case reports to characterize individuals who were employed or incarcerated in correctional facilities at time they were diagnosed with tuberculosis. Incidence was estimated with Bureau of Justice Statistics denominators. Results. Among 299 correctional employees with tuberculosis, 171 (57%) were US-born and 82 (27%) were female. Among 5579 persons incarcerated at the time of their tuberculosis diagnosis, 2520 (45%) were US-born and 495 (9%) were female. Median estimated annual tuberculosis incidence rates were 29 cases per 100 000 local jail inmates, 8 per 100 000 state prisoners, and 25 per 100 000 federal prisoners. The foreign-born proportion of incarcerated men 18 to 64 years old increased steadily from 33% in 2002 to 56% in 2013. Between 2009 and 2013, tuberculosis screenings were reported as leading to 10% of diagnoses among correctional employees, 47% among female inmates, and 42% among male inmates. Conclusions. Systematic screening and treatment of tuberculosis infection and disease among correctional employees and incarcerated individuals remain essential to tuberculosis prevention and control.
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- 2016
139. Upper Limb Musculoskeletal Modeling for Human-Exoskeleton Interaction
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Alberto Isaac Perez-SanPablo, Sergio Salazar-Cruz, Ricardo Lopez-Gutierrez, Marie-Christine Ho Ba Tho, Arturo Gonzalez-Mendoza, Tien Tuan Dao, and Ivette Quinones-Uriostegui
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business.product_category ,010504 meteorology & atmospheric sciences ,Computer science ,Interface (computing) ,05 social sciences ,Elbow ,Powered exoskeleton ,01 natural sciences ,Structure and function ,Exoskeleton ,Pulley ,medicine.anatomical_structure ,Control theory ,0502 economics and business ,medicine ,Upper limb ,050207 economics ,business ,human activities ,Simulation ,0105 earth and related environmental sciences - Abstract
The integration of the human body structure and function into the design of human-exoskeleton interface is an engineering challenge. A solution to overcome this problem is the use of musculoskeletal modeling tools such as OpenSIM. The objective of this paper is to develop and use an upper limb musculoskeletal model using OpenSIM to evaluate a Proportional Derivative controller (PD) of an exoskeleton. Obtained results show that the proposed musculoskeletal model could be a reliable tool for exoskeleton design study and controller testing when joint elbow speed is not superior to 300 °/ sec.
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- 2019
140. A Noninferiority Randomized Clinical Trial of the Use of the Smartphone-Based Health Applications IBDsmart and IBDoc in the Care of Inflammatory Bowel Disease Patients
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Murray L. Barclay, Holger Regenbrecht, Russell S. Walmsley, Tobias Langlotz, Andrew R Gray, Michael Schultz, Stephen Inns, Andrew McCombie, Nideen Visesio, and Christine Ho
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Adult ,Male ,medicine.medical_specialty ,Aftercare ,Disease ,Inflammatory bowel disease ,law.invention ,03 medical and health sciences ,Feces ,0302 clinical medicine ,Quality of life (healthcare) ,Randomized controlled trial ,law ,Internal medicine ,Surveys and Questionnaires ,Ambulatory Care ,Immunology and Allergy ,Medicine ,Humans ,030212 general & internal medicine ,mHealth ,Intention-to-treat analysis ,business.industry ,Gastroenterologists ,Remission Induction ,Gastroenterology ,Patient Acceptance of Health Care ,medicine.disease ,Inflammatory Bowel Diseases ,Mobile Applications ,Telemedicine ,Intention to Treat Analysis ,Clinical trial ,Quality of Life ,030211 gastroenterology & hepatology ,Female ,Smartphone ,Calprotectin ,Symptom Assessment ,business ,Leukocyte L1 Antigen Complex - Abstract
Background Providing timely follow-up care for patients with inflammatory bowel disease in remission is important but often difficult because of resource limitations. Using smartphones to communicate symptoms and biomarkers is a potential alternative. We aimed to compare outpatient management using 2 smartphone apps (IBDsmart for symptoms and IBDoc for fecal calprotectin monitoring) vs standard face-to-face care. We hypothesized noninferiority of quality of life and symptoms at 12 months plus a reduction in face-to-face appointments in the smartphone app group. Methods Inflammatory bowel disease outpatients (previously seen more often than annually) were randomized to smartphone app or standard face-to-face care over 12 months. Quality of life and symptoms were measured quarterly for 12 months. Acceptability was measured for gastroenterologists and patients at 12 months. Results One hundred people (73 Crohn’s disease, 49 male, average age 35 years) consented and completed baseline questionnaires (50 in each group). Intention-to-treat and per-protocol analyses revealed noninferiority of quality of life and symptom scores at 12 months. Outpatient appointment numbers were reduced in smartphone app care (P < 0.001). There was no difference in number of surgical outpatient appointments or number of disease-related hospitalizations between groups. Adherence to IBDsmart (50% perfect adherence) was slightly better than adherence to IBDoc (30% perfect adherence). Good acceptability was reported among most gastroenterologists and patients. Conclusions Remote symptom and fecal calprotectin monitoring is effective and acceptable. It also reduces the need for face-to-face outpatient appointments. Patients with mild-to-moderate disease who are not new diagnoses are ideal for this system. Clinical Trial Registration Number ACTRN12615000342516.
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- 2019
141. Optimal Disability Insurance with Informal Child Care
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Christine Ho
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Economics and Econometrics ,Child care ,Public economics ,05 social sciences ,Economics, Econometrics and Finance (miscellaneous) ,Subsidy ,Grandparent ,Day care ,Incentive ,Disability benefits ,0502 economics and business ,Family model ,Business ,050207 economics ,Disability insurance ,050205 econometrics - Abstract
The possibility of engaging in household child care may exacerbate the incentives of parents and grandparents to falsely claim disability benefits as households also get to save on formal child care costs. This paper considers a multi-generational family model with persistence in privately observed shocks and presents an efficient implementation case for subsidizing formal child care costs of the disabled. An implementation of the optimal scheme that consists of capped formal day care subsidies, non-linear income taxation and asset-testing is proposed. Simulations based on a parametrization that targets key features of the US labor and child care markets suggest that day care subsidies may lead to sizeable cost savings.
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- 2019
142. Knowledge Extraction From Medical Imaging for Advanced Patient-Specific Musculoskeletal Models
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Marie-Christine Ho Ba Tho and Tien Tuan Dao
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Decision support system ,medicine.diagnostic_test ,Computer science ,business.industry ,Magnetic resonance imaging ,Numerical models ,Patient specific ,Machine learning ,computer.software_genre ,Knowledge extraction ,Dynamic contrast-enhanced MRI ,medicine ,Medical imaging ,Artificial intelligence ,business ,computer ,Reliability (statistics) - Abstract
The objective of this article is to address the methodology developed to model the musculoskeletal systems with material, geometry, forces knowledge extracted from medical imaging. For hard tissue, from computed tomography personalized bone mechanical properties could be extracted and moreover its follow up could provide data for validation of patient-specific predictions. For soft tissue, mechanical, physical, and biochemical properties can be extracted from magnetic resonance imaging (MRI). Advanced MRI such as dynamic MRI and magnetic resonance elastrography allowed, respectively, to analyze the in vivo forces generated by the muscles in movement but also its mechanical properties in passive and active behavior. Based on these knowledges, patient-specific geometry, mechanical properties, and forces assessed are derived from advanced medical imaging techniques. These data are of importance for developing patient-specific computer modeling for prediction and evaluation of therapeutic, surgical, or functional rehabilitation treatments. Notions of reliability of the numerical models and uncertainty are addressed in order to provide an objective tool for aided decision support system to clinicians. Clinical applications will be given as illustrative examples.
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- 2019
143. A Systematic Review of Continuum Modeling of Skeletal Muscles: Current Trends, Limitations, and Recommendations
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Marie-Christine Ho Ba Tho and Tien Tuan Dao
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Current (mathematics) ,Computer science ,QH301-705.5 ,Multimodal data ,0206 medical engineering ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,02 engineering and technology ,Review Article ,Machine learning ,computer.software_genre ,03 medical and health sciences ,0302 clinical medicine ,In silico medicine ,medicine ,Biology (General) ,Representation (mathematics) ,Continuum Modeling ,business.industry ,Biophysical Phenomena ,Skeletal muscle ,020601 biomedical engineering ,medicine.anatomical_structure ,Active muscle ,Artificial intelligence ,business ,computer ,030217 neurology & neurosurgery ,TP248.13-248.65 ,Biotechnology - Abstract
Finite elasticity theory has been commonly used to model skeletal muscle. A very large range of heterogeneous constitutive laws has been proposed. In this review, the most widely used continuum models of skeletal muscles were synthetized and discussed. Trends and limitations of these laws were highlighted to propose new recommendations for future researches. A systematic review process was performed using two reliable search engines as PubMed and ScienceDirect. 40 representative studies (13 passive muscle materials and 27 active muscle materials) were included into this review. Note that exclusion criteria include tendon models, analytical models, 1D geometrical models, supplement papers, and indexed conference papers. Trends of current skeletal muscle modeling relate to 3D accurate muscle representation, parameter identification in passive muscle modeling, and the integration of coupled biophysical phenomena. Parameter identification for active materials, assumed fiber distribution, data assumption, and model validation are current drawbacks. New recommendations deal with the incorporation of multimodal data derived from medical imaging, the integration of more biophysical phenomena, and model reproducibility. Accounting for data uncertainty in skeletal muscle modeling will be also a challenging issue. This review provides, for the first time, a holistic view of current continuum models of skeletal muscles to identify potential gaps of current models according to the physiology of skeletal muscle. This opens new avenues for improving skeletal muscle modeling in the framework of in silico medicine.
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- 2018
144. Correction: Allied health professionals’ experiences and views towards improving musculoskeletal services in the UK for patients with musculoskeletal and co-existing mental health conditions: a qualitative study
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Rokhsaneh Tehrany, Dana Maki, Maria J C Teixeira, Tanya Chumak, and Christine Hoerz
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Diseases of the musculoskeletal system ,RC925-935 - Published
- 2024
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145. Geometrical evaluation from MRI of hip disorders in Legg-Calvé-Perthes disease.
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Philippe Pouletaut, Isabelle Claude, Renaud Winzenrieth, Marie Christine Ho Ba Tho, and Guy Sebag
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- 2003
146. Air dispersal of multidrug-resistant Acinetobacter baumannii: implication in nosocomial transmission during COVID-19 pandemic.
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Wong, S.-C., Lam, G.K.-M., Chen, J.H.-K., Li, X., Ip, F.T.-F., Yuen, L.L.-H., Chan, V.W.-M., AuYeung, C.H.-Y., So, S.Y.-C., Ho, P.-L., Yuen, K.-Y., Cheng, V.C.-C., Wong, Shuk-Ching, Lam, Germaine Kit-Ming, Chen, Jonathan Hon-Kwan, Li, Xin, Ip, Fanny Tung-Fun, Yuen, Lithia Lai-Ha, Chan, Veronica Wing-Man, and AuYeung, Christine Ho-Yan
- Abstract
We described the nosocomial transmission of multidrug-resistant Acinetobacter baumannii (MRAB) in an open-cubicle neurology ward with low ceiling height, where MRAB isolates collected in air, commonly shared items, non-reachable high-level surfaces and patients were analyzed epidemiologically and genetically by whole genome sequencing (WGS), which is the first study to understand the genetic relatedness of air, environmental, and clinical isolates of MRAB in the outbreak setting. Of 11 highly care dependent patients with 363 MRAB colonization-day during COVID-19 pandemic, ten (90.9%) and 9 (81.8%) had cutaneous and gastrointestinal colonization respectively. Of 160 environmental and air samples, 31 (19.4%) were MRAB-positive. The proportion of MRAB-contaminated commonly shared items was significantly lower in cohort than in non-cohort patient care (0/10,0% vs 12/18,66.7%;p<0.001). Air dispersal of MRAB was consistently detected during but not before diaper change in the cohort cubicle by 25-minute air sampling (4/4,100% vs 0/4,0%;p=0.029). Settle plate method revealed MRAB in 2 samples during diaper change. The proportion of MRAB-contaminated exhaust air grills was significantly higher when the cohort cubicle was occupied by 6 MRAB patients than when <6 patients were cared in the cubicle (5/9,55.6% vs 0/18,0%;p=0.002). The proportion of MRAB-contaminated non-reachable high-level surfaces was also significantly higher when there were ≥3 MRAB patients in the cohort cubicle (8/31,25.8% vs 0/24,0%;p=0.016). WGS revealed clonality of air, environment, and patients' isolates, suggestive of air dispersal of MRAB. Our findings support the view that that patient cohorting in enclosed cubicles with partition and closed door is preferred if single room is not available. [ABSTRACT FROM AUTHOR]
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- 2021
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147. Patients’ accounts of living with and managing inflammatory bowel disease in rural Southern New Zealand: a qualitative study
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Trudy Sullivan, Christine Ho, Fiona Doolan-Noble, Michael Schultz, Tim Stokes, Geoff Noller, Lauralie Richard, Andrew McCombie, and Sarah Derrett
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Adult ,Male ,Rural Population ,medicine.medical_specialty ,Health Personnel ,media_common.quotation_subject ,Judgement ,Exploratory research ,Gastroenterology and Hepatology ,Disease ,organisation of health services ,Rurality ,Nursing ,inflammatory bowel disease ,Health care ,medicine ,Humans ,Aged ,media_common ,business.industry ,General Medicine ,Middle Aged ,Inflammatory Bowel Diseases ,Feeling ,Family medicine ,Medicine ,Female ,Grief ,Psychology ,business ,qualitative research ,New Zealand ,Qualitative research - Abstract
ObjectiveTo explore how adults living with Inflammatory Bowel Disease (IBD) in rural New Zealand manage their condition and engage with health care providers.DesignQualitative exploratory design with semi-structured interviews analysed thematically.Setting and participantsInterviews were conducted with 18 people living with IBD in the Otago region of the South Island.ResultsFive important constructs were identified: 1. Journey to confirming and accepting diagnosis; 2. Importance of the relationship with the health care team; 3. Support from others; 4. Learning how to manage IBD; and 5. Care at a distance - experiences of rurality. Pathways to confirming diagnosis involved two contrasting journeys: a long and slow process where diagnosis remained unclear for a prolonged period, and a more acute process where diagnosis typically came as a shock. Central to the acceptance process was acknowledging the chronicity of the condition, which involved feelings of grief but also the fear of judgement and stigma. Building a strong relationship with the specialist was central to medical management, particularly in the initial stage following diagnosis. Support from others was critical, enabling participants to progress through acceptance of the disease and developing confidence in its everyday management. Participants shared different strategies on how to manage IBD, describing a “trial and error” process of “finding what’s right” at different stages of the condition. Managing IBD rurally involved challenges of access to specialist care, with perceptions of delayed referrals and concerns about disparities in specialist access compared to urban counterparts. Rural living also had financial implications - cost of time and cost of mobilising resources for long travels to the urban centre for treatments.ConclusionsFindings from this study provide a rich understanding of the complex health journeys of people living with IBD and the challenges of managing the condition rurally.STRENGTHS AND LIMITATIONS OF THIS STUDY
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- 2020
148. Local colonisations and extinctions of European birds are poorly explained by changes in climate suitability
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Christine Howard, Emma-Liina Marjakangas, Alejandra Morán-Ordóñez, Pietro Milanesi, Aleksandre Abuladze, Karen Aghababyan, Vitalie Ajder, Volen Arkumarev, Dawn E. Balmer, Hans-Günther Bauer, Colin M. Beale, Taulant Bino, Kerem Ali Boyla, Ian J. Burfield, Brian Burke, Brian Caffrey, Tomasz Chodkiewicz, Juan Carlos Del Moral, Vlatka Dumbovic Mazal, Néstor Fernández, Lorenzo Fornasari, Bettina Gerlach, Carlos Godinho, Sergi Herrando, Christina Ieronymidou, Alison Johnston, Mihailo Jovicevic, Mikhail Kalyakin, Verena Keller, Peter Knaus, Dražen Kotrošan, Tatiana Kuzmenko, Domingos Leitão, Åke Lindström, Qenan Maxhuni, Tomaž Mihelič, Tibor Mikuska, Blas Molina, Károly Nagy, David Noble, Ingar Jostein Øien, Jean-Yves Paquet, Clara Pladevall, Danae Portolou, Dimitrije Radišić, Saša Rajkov, Draženko Z. Rajković, Liutauras Raudonikis, Thomas Sattler, Darko Saveljić, Paul Shimmings, Jovica Sjenicic, Karel Šťastný, Stoycho Stoychev, Iurii Strus, Christoph Sudfeldt, Elchin Sultanov, Tibor Szép, Norbert Teufelbauer, Danka Uzunova, Chris A. M. van Turnhout, Metodija Velevski, Thomas Vikstrøm, Alexandre Vintchevski, Olga Voltzit, Petr Voříšek, Tomasz Wilk, Damaris Zurell, Lluís Brotons, Aleksi Lehikoinen, and Stephen G. Willis
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Science - Abstract
Abstract Climate change has been associated with both latitudinal and elevational shifts in species’ ranges. The extent, however, to which climate change has driven recent range shifts alongside other putative drivers remains uncertain. Here, we use the changing distributions of 378 European breeding bird species over 30 years to explore the putative drivers of recent range dynamics, considering the effects of climate, land cover, other environmental variables, and species’ traits on the probability of local colonisation and extinction. On average, species shifted their ranges by 2.4 km/year. These shifts, however, were significantly different from expectations due to changing climate and land cover. We found that local colonisation and extinction events were influenced primarily by initial climate conditions and by species’ range traits. By contrast, changes in climate suitability over the period were less important. This highlights the limitations of using only climate and land cover when projecting future changes in species’ ranges and emphasises the need for integrative, multi-predictor approaches for more robust forecasting.
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- 2023
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149. How prices and income influence global patterns in saturated fat intake by age, sex and world region: a cross-sectional analysis of 160 countries
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Albertino Damasceno, Cristina Palacios, Anoop Misra, Parvin Mirmiran, Nizal Sarrafzadegan, Simon Anderson, Ingibjorg Gunnarsdottir, Yanping Li, Anand Krishnan, Yu Chen, Alireza Esteghamati, Farshad Farzadfar, Giuseppe Grosso, Reza Malekzadeh, Sumathi Swaminathan, Patricio Lopez-Jaramillo, Noushin Mohammadifard, Jean-Michel Gaspoz, Pedro Marques-Vidal, Idris Guessous, Tal Shimony, Lital Keinan-Boker, Carukshi Arambepola, Antonia Trichopoulou, Marialaura Bonaccio, Simona Costanzo, Licia Iacoviello, Andrew Muhammad, Wen-Harn Pan, Manami Inoue, Peter Vollenweider, Luz Maria Sanchez-Romero, Carl Lachat, Demosthenes Panagiotakos, Sangita Sharma, Eva Roos, Milton Severo, Safiah Yusof, Nuno Lunet, Roya Kelishadi, Anuradha Khadilkar, Cho-il Kim, Veena Ekbote, Masoud Mirzaei, Inge Huybrechts, Lluis Serra-Majem, Anjum Memon, Aminul Haque, Katia Castetbon, Saeed Dastgiri, Julia Reedy, Abla M. Sibai, Xia Cao, Pascal Bovet, Pamela Abbott, Karen Charlton, Hsing-Yi Chang, Yasuhiro Matsumura, Yoonsu Cho, Puneet Misra, Morteza Abdollahi, Suad Al-Hooti, Anahita Houshiar-rad, Eda Koksal, Abdulrahman Musaiger, Gulden Pekcan, Sahar Zaghloul, Yves Martin-Prevel, Kyungwon Oh, Meei-Shyuan Lee, Sirje Vaask, Shu Wen Ng, Simon Forsyth, Dimitrios Trichopoulos, Erkki Vartiainen, Christian Haerpfer, Carla Lopes, Foong Ming Moy, Tor Strand, Mohammadreza Pakseresht, Yi Ma, Androniki Naska, Dorothy Gauci, Ibrahim Elmadfa, Wilbur Hadden, Hajah Masni Ibrahim, Lars Johansson, Hae-Jeung Lee, Nur Indrawaty Lipoeto, Balakrishna Nagalla, Stefka Petrova, Noppawan Piaseu, Laufey Steingrimsdottir, Lucjan Szponar, Holmfridur Thorgeirsdóttir, Inga Thorsdottir, Aida Turrini, Anna Waskiewicz, Gábor Zajkás, Harikumar Rachakulla, Heléne Enghardt Barbieri, Nattinee Jitnarin, Le Tran Ngoan, Jaana Lindström, Kalyana Sundram, Ranil Jayawardena, Irina Kovalskys, Noël Barengo, Zaleha Abdullah Mahdy, Maryam Hashemian, Duarte Torres, Angélica Ochoa, Pulani Lanerolle, Chandrashekar Janakiram, Fatemeh Vida Zohoori, Parvin Abedi, Suvi Virtanen, Amelia Ahles, Jacqueline N Yenerall, Mustafa Arici, Amy Luke, Suhad Abumweis, Mohannad Al Nsour, Iftikhar Alam, Nasser Al-Daghri, Shaun Sabico, alHamad Nawal Ai, Eman Alissa, Sameer Al-Zenki, Karim Anzid, Joanne Arsenault Hacettepe, Renzo Asciak, Lajos Biró, Juan Rivera Dommarco, Daniel Illescas-Zarate, Sonia Rodriguez Ramirez, Ivonne Ramirez Silva, Per Bergman, Anna Karin Lindroos, Jessica Petrelius Sipinen, Sesikeran Boindala, Mauricio T. Caballero, FNeville Calleja, Mario Capanzana, Jan Carmikle, Michelle Castro, Corazon Cerdena, Shashi Chiplonkar, Khun-Aik Chuah, IRCCS INM Neuromed, Stefaan De Henauw, Karin DeRidder, Eric Ding, Rokiah Don, Charmaine Duante, Vesselka Duleva, Samuel Duran Aguero, Jalila El Ati, Alison Eldridge, Tatyana El-kour, Laetitia Nikiema, Zohreh Etemad, Fariza Fadzil, Mei Fen Chan, Anne Fernandez, Dulitha Fernando, Regina Fisberg, Edna Gamboa Delgado, J Brahmam Ginnela, Aida Hadziomeragic, Jemal Haidar Ali, Rubina Hakeem, Rajkumar Hemalatha, Avula Laxmaiah, Indrapal Meshram, Nimmathota Arlappa, Sigrun Henjum, Hristo Hinkov, Zaiton Hjdaud, Daniel Hoffman, Beth Hopping, Shu-Yi Hung Yao-Te Hsieh, Nahla Chawkat Hwalla, Nayu Ikeda, Olof Jonsdottir, Rajesh Jeewon, Ola Kally, Mirnalini Kandiah, Tilakavati Karupaiah, Rebecca Goldsmith, Jurgen Konig, Liisa Korkalo, Riitta Freese, Jeremy Koster, Herculina Kruger, Rebecca Kuriyan-Raj, Sanghui Kweon, Sihyun Park, Yuen Lai, Indu Waidyatilaka, Catherine Leclercq, J Lennert Veerman, Lydia Lera Marques, Annie Ling, Widjaja Lukito, Elisabette Lupotto, Stefania Sette, Raffaela Piccinelli, Wan Manan, Dirce Marchioni, Angie Mathee, Paramita Mazumdar, Gert Mensink, Alexa Meyer, Claudette Mitchell, David Balfour, Moses Mwangi, Maryam Maghroun, Fatemeh Mohammadi-Nasrabadi, Zalilah Mohd Shariff, Elizabeth Mwaniki, Jannicke Myhre, Augustin Nawidimbasba Zeba, Sina Noshad, Marga Ocke, Jillian Odenkirk, Mariana Oleas, Sonia Olivares, Johana Ortiz-Ulloa, Johanna Otero, Rajendra Parajuli, Luz Posada, Farhad Pourfarzi, Alan Martin Preston, Ingrid Rached, Ali Reza Rahbar, Colin Rehm, Makiko Sekiyama, Rusidah Selamat, Khadijah Shamsuddin, Harri Sinkko, Milton Fabian Suarez-Ortegon, Elzbieta Sygnowska, Maria Szabo, Ilse Khouw, Swee Ai Ng, Heli Tapanainen FrieslandCampina, Reema Tayyem, Bemnet Tedla, Coline van Oosterhout, Marieke Vossenaar, Eva Warensjo Lemming, Lothar Wieler, Mabel Yap, Maria Elisa Zapata, Khairul Zarina, Zipporah Bukania, Yeri Kombe, Julie Long, K. Michael Hambidge, Tshilenge S. Diba, Umber S. Khan, Gabriela Tejeda, Cornelia Tudorie, Anca Nicolau, Amanda de Moura Souza, Alan de Brauw, Mourad Moursi, Alicia Rovirosa, Carol Henry, Getahun Ersino, Gordon Zello, Chanthaly Luangphaxay, Daovieng Douangvichit, Latsamy Siengsounthone, Christine Hotz, Constance Rybak, Corina Aurelia Zugravu, Donka Baykova, Elizabeth Yakes-Jimenez, Gudrun B. Keding, Lydiah M. Waswa, Irmgard Jordan, J.V. Meenakshi, Laila Eleraky, Wolfgang Stuetz, Lalka Rangelova, Lilian Aluso, Julia Boedecker, Francis Oduor, Tamene Taye Asayehu, Veronika Janská, Ward Siamusantu, and Ken Brown
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Medicine - Abstract
Objective When considering proposals to improve diets, it is important to understand how factors like price and income can affect saturated fat (SF) intake and demand. In this study, we examine and estimate the influence of price and income on intake across 160 countries, by age and sex, and derive sensitivity measures (price elasticities) that vary by age, sex and world region.Design We econometrically estimate intake responsiveness to income and prices across countries, accounting for differences by world region, age and sex. Intake data by age, sex and country were obtained from the 2018 Global Dietary Database. These data were then linked to global price data for select food groups from the World Bank International Comparison Programme and income data from the World Development Indicators Databank (World Bank).Results Intake differences due to price were highly significant, with a 1% increase in price associated with a lower SF intake (% energy/d) of about 4.3 percentage points. We also find significant differences across regions. In high-income countries, median (age 40) intake reductions were 1.4, 0.8 and 0.2 percentage points, given a 1% increase in the price of meat, dairy, and oils and fats, respectively. Price elasticities varied with age but not sex. Intake differences due to income were insignificant when regional binary variables were included in the analysis.Conclusion The results of this study show heterogeneous associations among prices and intake within and across countries. Policymakers should consider these heterogeneous effects as they address global nutrition and health challenges.
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- 2024
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150. Incense Burning during Pregnancy and Birth Weight and Head Circumference among Term Births: The Taiwan Birth Cohort Study
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Christine Ho and Le-Yu Chen
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Adult ,Male ,Cephalometry ,Health, Toxicology and Mutagenesis ,Birth weight ,Taiwan ,010501 environmental sciences ,Risk Assessment ,01 natural sciences ,Incense ,Cohort Studies ,Young Adult ,Pregnancy ,Smoke ,0502 economics and business ,Birth Weight ,Humans ,Medicine ,050207 economics ,0105 earth and related environmental sciences ,Air Pollutants ,business.industry ,05 social sciences ,Public Health, Environmental and Occupational Health ,medicine.disease ,Head circumference ,Air Pollution, Indoor ,Children's Health ,Term Birth ,Female ,business ,Birth cohort ,Environmental Monitoring ,Demography ,Cohort study - Abstract
Background: Incense burning for rituals or religious purposes is an important tradition in many countries. However, incense smoke contains particulate matter and gas products such as carbon monoxide, sulfur, and nitrogen dioxide, which are potentially harmful to health. Objectives: We analyzed the relationship between prenatal incense burning and birth weight and head circumference at birth using the Taiwan Birth Cohort Study. We also analyzed whether the associations varied by sex and along the distribution of birth outcomes. Methods: We performed ordinary least squares (OLS) and quantile regressions analysis on a sample of 15,773 term births (> 37 gestational weeks; 8,216 boys and 7,557 girls) in Taiwan in 2005. The associations were estimated separately for boys and girls as well as for the population as a whole. We controlled extensively for factors that may be correlated with incense burning and birth weight and head circumference, such as parental religion, demographics, and health characteristics, as well as pregnancy-related variables. Results: Findings from fully adjusted OLS regressions indicated that exposure to incense was associated with lower birth weight in boys (–18 g; 95% CI: –36, –0.94) but not girls (1 g; 95% CI: –17, 19; interaction p-value = 0.31). Associations with head circumference were negative for boys (–0.95 mm; 95% CI: –1.8, –0.16) and girls (–0.71 mm; 95% CI: –1.5, 0.11; interaction p-values = 0.73). Quantile regression results suggested that the negative associations were larger among the lower quantiles of birth outcomes. Conclusions: OLS regressions showed that prenatal incense burning was associated with lower birth weight for boys and smaller head circumference for boys and girls. The associations were more pronounced among the lower quantiles of birth outcomes. Further research is necessary to confirm whether incense burning has differential effects by sex. Citation: Chen LY, Ho C. 2016. Incense burning during pregnancy and birth weight and head circumference among term births: The Taiwan Birth Cohort Study. Environ Health Perspect 124:1487–1492; http://dx.doi.org/10.1289/ehp.1509922
- Published
- 2016
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