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This paper presents a multi-channel acoustic transducer that works within the audible frequency range (250-5500 Hz) and mimics the operation of the cochlea by filtering incoming sound. The transducer is composed of eight thin film piezoelectric cantilever beams with different resonance frequencies. The transducer is well suited to be implanted in middle ear cavity with an active volume of 5 mm $\times5$ mm $\times0.62$ mm and mass of 4.8 mg. Resonance frequencies and piezoelectric outputs of the beams are modeled with Finite Element Method (FEM). Vibration experiments showed that the transducer is capable of generating up to 139.36 mV $_{{\mathrm {pp}}}$ under 0.1 g excitation. Test results are consistent with the FEM model on frequency (97%) and output voltage (89%) values. Device was further tested with acoustic excitation on an artificial tympanic membrane and flexible substrate. Under acoustic excitation, 50.7 mV $_{{\mathrm {pp}}}$ output voltage generated under 100 dB Sound Pressure Level (SPL). Output voltages observed in acoustical and mechanical characterizations are the highest values reported to the best of our knowledge. Finally, to assess the feasibility of the transducer in daily sound levels, it was excited with a speech sample and output signal was recovered. Time-domain waveforms of the recorded and recovered signals showed close patterns. [ABSTRACT FROM AUTHOR]

Objectives: The purpose of this study is to develop a biophysical model of human spiral ganglion neurons (SGNs) that includes voltage-gated hyperpolarization-activated cation (HCN) channels and low-threshold potassium voltage-gated, delayed-rectifier low-threshold potassium (KLT) channels, providing for a more complete simulation of spike-rate adaptation, a feature of most spiking neurons in which spiking activity is reduced in response to sustained stimulation. Methods: Our model incorporates features of spike-rate adaptation reported from in vivo studies, whilst also displaying similar behaviour to existing models of human SGNs, including the dependence of electrically evoked thresholds on the polarity of electrical pulses. Results: Hypothesizing that the mode of stimulation-intracellular or extracellular-predicts features of spike-rate adaptation similar to in vivo studies, including the influence of stimulus intensity and pulse-rate, we find that the mode of stimulation alters features of spike-rate adaptation. In particular, the reduction in spiking over time with sustained input was generally greater for extracellular, compared to intracellular, stimulation, when simulating a multi-compartment SGN with human morphological features. In contrast, time-constants of spike-rate adaption reported for in vivo data did not fit our predicted responses, highlighting the need for a more complete physiological understanding of the factors contributing to spike-rate adaptation in electrically stimulated human SGNs. Conclusion: Our model extends previous computational models of SGNs with human morphology with ionic channels accounting for features of spike-rate adaptation. Significance: The significance of this work resides in the ability to improve the modeling of cochlear implant (CI) stimulation and its effects on neural responses. This will help develop novel, and perhaps personalised, stimulation strategies to reduce variability in CI user outcomes. [ABSTRACT FROM AUTHOR]

Introduction: Thyroid hormones play a significant role in the normal development of auditory system. Hearing loss is the most common otorhinolaryngological manifestation associated with hypothyroidism. Objective:To study the association between hypothyroidism and hearing loss and to evaluate the effect of levothyroxine on hearing loss. Methods:The study included 50 subjects (100 ears) divided into two groups. Case group included clinically and biochemically confirmed hypothyroid patients (Hypothyroid group, n=25) and control group included euthyroid subjects (Control group, n=25). Otologic examination, Pure tone audiometry (PTA) and thyroid function tests were done on all the subjects. Results:Pure tone audiometric (PTA) testing revealed hearing loss in 38/50 ears (76 %) in hypothyroid group compared to only 2/50 ears (4%) in the control group. Sensorineural hearing loss was the most common type of hearing loss seen in hypothyroid group (52%) compared to only 2% in the control group. Sensorineural hearing loss was bilateral, and mostly mild. 14/38 ears (36.8%) showed improvement in hearing thresholds with levothyroxine therapy for 3 months. Conclusion:Hypothyroid patients had significant degree of hearing impairment compared to control group with statistically significant improvement in hearing thresholds after treatment. So, in patients with hypothyroidism, hearing evaluation using pure tone audiometry helps in the early detection of hearing loss and thus treatment could be started. [ABSTRACT FROM AUTHOR]

Mosquito hearing is a complex process primarily involved in intraspecific communication between males and females. Although mosquitoes previously were believed to possess a relatively rudimentary auditory system, we now know that they can hear sounds at greater distances and process sounds through an efferent pathway, similar to vertebrates. In mating swarms, mosquitoes use acoustic signals created by conspecific wingbeats to locate and respond to one another through harmonic convergence. Male capture is an emerging area of interest for monitoring sterile insect release programs, and numerous studies have explored using female flight tones (wing-beat frequencies) to attract and capture male mosquitoes by altering or developing novel acoustic traps. It is also important to consider sound pattern, volume, and sound pressure levels of broadcasted noises, as well as implementing other attractive cues, such as swarm markers, to acoustic traps to increase success in the field. Female attraction to sound-baited traps has also been explored in the laboratory and field, using frequencies similar to male wing-beats and stereotypical vertebrate host calls, such as frogs and birds. In this review, the physiological and behavioral aspects of mosquito hearing are explored, as well as the importance of acoustic signals for mate choice and successful mating. The use of acoustic traps for male and female capture are discussed, as well as the implications for vector surveillance, and the limitations to using these traps. [ABSTRACT FROM AUTHOR]

Attentive listening in a multispeaker environment such as a cocktail party requires suppression of the interfering speakers and the noise around. People with normal hearing perform remarkably well in such situations. Analysis of the cortical signals using electroencephalography (EEG) has revealed that the EEG signals track the envelope of the attended speech stronger than that of the interfering speech. This has enabled the development of algorithms that can decode the selective attention of a listener in controlled experimental settings. However, often these algorithms require longer trial duration and computationally expensive calibration to obtain a reliable inference of attention. In this paper, we present a novel framework to decode the attention of a listener within trial durations of the order of two seconds. It comprises of three modules: 1) Dynamic estimation of the temporal response functions (TRF) in every trial using a sequential linear minimum mean squared error (LMMSE) estimator, 2) Extract the N1 $-$ P2 peak of the estimated TRF that serves as a marker related to the attentional state, and 3) Obtain a probabilistic measure of the attentional state using a support vector machine followed by a logistic regression. The efficacy of the proposed decoding framework was evaluated using EEG data collected from 27 subjects. The total number of electrodes required to infer the attention was four: One for the signal estimation, one for the noise estimation and the other two being the reference and the ground electrodes. Our results make further progress towards the realization of neuro-steered hearing aids. [ABSTRACT FROM AUTHOR]

Hyperacusis is highly prevalent in the autism spectrum disorder (ASD) population. This auditory hypersensitivity can trigger pragmatically atypical reactions that may impact social and academic domains. Objective: The aim of this report is to describe the relationship between decreased sound tolerance disorders and the ASD population. Topics covered: The main topics discussed include (1) assessment and prevalence of hyperacusis in ASD; (2) etiology of hyperacusis in ASD; (3) treatment of hyperacusis in ASD. Conclusions: Knowledge of the assessment and treatment of decreased sound tolerance disorders within the ASD population is growing and changing. [ABSTRACT FROM AUTHOR]

This paper presents a field-programmable gate array (FPGA) implementation of an auditory system, which is biologically inspired and has the advantages of robustness and anti-noise ability. We propose an FPGA implementation of an eleven-channel hierarchical spiking neuron network (SNN) model, which has a sparsely connected architecture with low power consumption. According to the mechanism of the auditory pathway in human brain, spiking trains generated by the cochlea are analyzed in the hierarchical SNN, and the specific word can be identified by a Bayesian classifier. Modified leaky integrate-and-fire (LIF) model is used to realize the hierarchical SNN, which achieves both high efficiency and low hardware consumption. The hierarchical SNN implemented on FPGA enables the auditory system to be operated at high speed and can be interfaced and applied with external machines and sensors. A set of speech from different speakers mixed with noise are used as input to test the performance our system, and the experimental results show that the system can classify words in a biologically plausible way with the presence of noise. The method of our system is flexible and the system can be modified into desirable scale. These confirm that the proposed biologically plausible auditory system provides a better method for on-chip speech recognition. Compare to the state-of-the-art, our auditory system achieves a higher speed with a maximum frequency of 65.03 MHz and a lower energy consumption of 276.83 μJ for a single operation. It can be applied in the field of brain-computer interface and intelligent robots. [ABSTRACT FROM AUTHOR]

Type 2 deiodinase (Dio2) amplifies levels of 3,5,3′-L-triiodothyronine (T3), the active form of thyroid hormone, and is essential for cochlear maturation and auditory development. However, cellular routes for endocrine signaling in the compartmentalized, anatomically complex cochlea are little understood. Dio2 generates T3 from thyroxine (T4), a more abundant thyroid hormone precursor in the circulation, and is dramatically induced in the cochlea before the onset of hearing. The evidence implies that specific Dio2-expressing cell types critically mediate T3 signaling but these cell types are poorly defined because Dio2 is expressed transiently at low levels. Here, using a Dio2 CreERt2 knockin that activates a fluorescent reporter, we define Dio2-expressing cochlear cell types at high resolution in male or female mice. Dio2-positive cells were detected in vascularized supporting tissues but not in avascular internal epithelia, indicating segregation of T3-generating and T3-responding tissues. In the spiral ligament and spiral limbus, Dio2-positive fibrocytes clustered around vascular networks that convey T4 into cochlear tissues. In the otic capsule, Dio2-positive osteoblasts localized at cartilage surfaces as the bony labyrinth matures. We corroborated the identities of Dio2-positive lineages by RNA-sequencing of individual cells. The results suggest a previously unrecognized role for fibrocytes in mediating hormonal signaling. We discuss a model whereby fibrocytes mediate paracrine-like control of T3 signaling to the organ of Corti and epithelial target tissues. [ABSTRACT FROM AUTHOR]

One of the current gaps in teleaudiology is the lack of methods for adult hearing screening viable for use in individuals of unknown language and in varying environments. We have developed a novel automated speech-in-noise test that uses stimuli viable for use in non-native listeners. The test reliability has been demonstrated in laboratory settings and in uncontrolled environmental noise settings in previous studies. The aim of this study was: (i) to evaluate the ability of the test to identify hearing loss using multivariate logistic regression classifiers in a population of 148 unscreened adults and (ii) to evaluate the ear-level sound pressure levels generated by different earphones and headphones as a function of the test volume. The multivariate classifiers had sensitivity equal to 0.79 and specificity equal to 0.79 using both the full set of features extracted from the test as well as a subset of three features (speech recognition threshold, age, and number of correct responses). The analysis of the ear-level sound pressure levels showed substantial variability across transducer types and models, with earphones levels being up to 22 dB lower than those of headphones. Overall, these results suggest that the proposed approach might be viable for hearing screening in varying environments if an option to self-adjust the test volume is included and if headphones are used. Future research is needed to assess the viability of the test for screening at a distance, for example by addressing the influence of user interface, device, and settings, on a large sample of subjects with varying hearing loss. [ABSTRACT FROM AUTHOR]

Neuronal development in the inner ear is initiated by expression of the proneural basic Helix-Loop-Helix (bHLH) transcription factor Neurogenin1 that specifies neuronal precursors in the otocyst. The initial specification of the neuroblasts within the otic epithelium is followed by the expression of an additional bHLH factor, Neurod1. Although NEUROD1 is essential for inner ear neuronal development, the different aspects of the temporal and spatial requirements of NEUROD1 for the inner ear and, mainly, for auditory neuron development are not fully understood. In this study, using Foxg1Cre for the early elimination of Neurod1 in the mouse otocyst, we showed that Neurod1 deletion results in a massive reduction of differentiating neurons in the otic ganglion at E10.5, and in the diminished vestibular and rudimental spiral ganglia at E13.5. Attenuated neuronal development was associated with reduced and disorganized sensory epithelia, formation of ectopic hair cells, and the shortened cochlea in the inner ear. Central projections of inner ear neurons with conditional Neurod1 deletion are reduced, unsegregated, disorganized, and interconnecting the vestibular and auditory systems. In line with decreased afferent input from auditory neurons, the volume of cochlear nuclei was reduced by 60% in Neurod1 mutant mice. Finally, our data demonstrate that early elimination of Neurod1 affects the neuronal lineage potential and alters the generation of inner ear neurons and cochlear afferents with a profound effect on the first auditory nuclei, the cochlear nuclei.

Before hearing onset (postnatal day 12 in mice), inner hair cells (IHCs) spontaneously fire action potentials, thereby driving pre-sensory activity in the ascending auditory pathway. The rate of IHC action potential bursts is modulated by inner supporting cells (ISCs) of Kölliker’s organ through the activity of the Ca2+-activated Cl--channel TMEM16A (ANO1). Here, we show that conditional deletion of Ano1 (Tmem16a) in mice disrupts Ca2+ waves within Kölliker’s organ, reduces the burst-firing activity and the frequency selectivity of auditory brainstem neurons in the medial nucleus of the trapezoid body (MNTB), and also impairs the functional refinement of MNTB projections to the lateral superior olive. These results reveal the importance of the activity of Kölliker’s organ for the refinement of central auditory connectivity. In addition, our study suggests the involvement of TMEM16A in the propagation of Ca2+ waves, which may also apply to other tissues expressing TMEM16A.

Many animals employ a second frequency filter beyond the initial filtering of the eardrum (or tympanal membrane). In the field cricket ear, both the filtering mechanism and the transmission path from the posterior tympanal membrane (PTM) have remained unclear. A mismatch between PTM vibrations and sensilla tuning has prompted speculations of a second filter. PTM coupling to the tracheal branches is suggested to support a transmission pathway. Here, we present three independent lines of evidence converging on the same conclusion: the existence of a series of linked membranes with distinct resonant frequencies serving both filtering and transmission functions. Micro-computed tomography (µ-CT) highlighted the 'dividing membrane (DivM)', separating the tracheal branches and connected to the PTM via the dorsal membrane of the posterior tracheal branch (DM-PTB). Thickness analysis showed the DivM to share significant thinness similarity with the PTM. Laser Doppler vibrometry indicated the first of two PTM vibrational peaks, at 6 and 14 kHz, originates not from the PTM but from the coupled DM-PTB. This result was corroborated by µ-CT-based finite element analysis. These findings clarify further the biophysical source of neuroethological pathways in what is an important model of behavioural neuroscience. Tuned microscale coupled membranes may also hold biomimetic relevance.

Rapid recognition and categorization of sounds are essential for humans and animals alike, both for understanding and reacting to our surroundings and for daily communication and social interaction. For humans, perception of speech sounds is of crucial importance. In real life, this task is complicated by the presence of a multitude of meaningful non‐speech sounds. The present behavioural, magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) study was set out to address how attention to speech versus attention to natural non‐speech sounds within complex auditory scenes influences cortical processing. The stimuli were superimpositions of spoken words and environmental sounds, with parametric variation of the speech‐to‐environmental sound intensity ratio. The participants' task was to detect a repetition in either the speech or the environmental sound. We found that specifically when participants attended to speech within the superimposed stimuli, higher speech‐to‐environmental sound ratios resulted in shorter sustained MEG responses and stronger BOLD fMRI signals especially in the left supratemporal auditory cortex and in improved behavioural performance. No such effects of speech‐to‐environmental sound ratio were observed when participants attended to the environmental sound part within the exact same stimuli. These findings suggest stronger saliency of speech compared with other meaningful sounds during processing of natural auditory scenes, likely linked to speech‐specific top‐down and bottom‐up mechanisms activated during speech perception that are needed for tracking speech in real‐life‐like auditory environments. [ABSTRACT FROM AUTHOR]

Since the hard of hearing cannot communicate effectively with the non-disabled, which may cause various inconveniences. As an essential member of a harmonious society, it is particularly urgent to solve their communication problems with non-disabled people. Effective communication between the hard of hearing and the non-disabled has become possible with the continuous development of artificial intelligence. In this paper, an intelligent human-computer interaction system is designed to solve communication inconvenience between the hard of hearing and the non-disabled. This system combines artificial intelligence with wearable devices and classifies gestures with BP neural network, effectively solving the communication problem between the hard of hearing and the non-disabled. [ABSTRACT FROM AUTHOR]

Background and Aim: Tinnitus is one of the most difficult challenges in audiology and otology. Previous studies have been shown that tinnitus may interfere with the function of central auditory system (CAS). Involvement of CAS abilities including speech perception and auditory processing has led to serious problems in people with tinnitus. Due to the lack of enough information about the impact of tinnitus on CAS and its function, and given that there is no standardized protocol for assessment and management of tinnitus, this study aimed to review the studies on the effect of tinnitus on the CAS function. Recent Findings: Sixteen eligible articles were reviewed. Temporal and spectral resolution, frequency differentiation and speech perception deficits were reported in patients with tinnitus, especially in background noise. This was reported even in tinnitus patients with normal hearing. Conclusion: Assessment of central auditory processing and speech perception in noise seems to be useful for proper management of tinnitus in clinical practice. [ABSTRACT FROM AUTHOR]

Echolocating big brown bats (Eptesicus fuscus) perceive their surroundings by broadcasting frequency-modulated (FM) ultrasonic pulses and processing returning echoes. Bats echolocate in acoustically cluttered environments containing multiple objects, where each broadcast is followed by multiple echoes at varying time delays. The bat must decipher this complex echo cascade to form a coherent picture of the entire acoustic scene. Neurons in the bat's inferior colliculus (IC) are selective for specific acoustic features of echoes and time delays between broadcasts and echoes. Because of this selectivity, different subpopulations of neurons are activated as the bat flies through its environment, while the physical scene itself remains unchanging. We asked how a neural representation based on variable single-neuron responses could underlie a cohesive perceptual representation of a complex scene. We recorded local field potentials from the IC of big brown bats to examine population coding of echo cascades similar to what the bat might encounter when flying alongside vegetation. We found that the temporal patterning of a simulated broadcast followed by an echo cascade is faithfully reproduced in the population response at multiple stimulus amplitudes and echo delays. Local field potentials to broadcasts and echo cascades undergo amplitude-latency trading consistent with single-neuron data but rarely show paradoxical latency shifts. Population responses to the entire echo cascade move as a unit coherently in time as broadcast-echo cascade delay changes, suggesting that these responses serve as an index for the formation of a cohesive perceptual representation of an acoustic scene. [ABSTRACT FROM AUTHOR]

When multiple speakers talk simultaneously, a hearing device cannot identify which of these speakers the listener intends to attend to. Auditory attention decoding (AAD) algorithms can provide this information by, for example, reconstructing the attended speech envelope from electroencephalography (EEG) signals. However, these stimulus reconstruction decoders are traditionally trained in a supervised manner, requiring a dedicated training stage during which the attended speaker is known. Pre-trained subject-independent decoders alleviate the need of having such a per-user training stage but perform substantially worse than supervised subject-specific decoders that are tailored to the user. This motivates the development of a new unsupervised self-adapting training/updating procedure for a subject-specific decoder, which iteratively improves itself on unlabeled EEG data using its own predicted labels. This iterative updating procedure enables a self-leveraging effect, of which we provide a mathematical analysis that reveals the underlying mechanics. The proposed unsupervised algorithm, starting from a random decoder, results in a decoder that outperforms a supervised subject-independent decoder. Starting from a subject-independent decoder, the unsupervised algorithm even closely approximates the performance of a supervised subject-specific decoder. The developed unsupervised AAD algorithm thus combines the two advantages of a supervised subject-specific and subject-independent decoder: it approximates the performance of the former while retaining the ‘plug-and-play’ character of the latter. As the proposed algorithm can be used to automatically adapt to new users, as well as over time when new EEG data is being recorded, it contributes to more practical neuro-steered hearing devices. [ABSTRACT FROM AUTHOR]

As a key technology to help bridging the gap between deaf and hearing people, sign language recognition (SLR) has become one of the most active research topics in the human–computer interaction field. Although several SLR methodologies have been proposed, the development of a real-world SLR system is still a very challenging task. One of the main challenges is related to the large intersigner variability that exists in the manual signing process of sign languages. To address this problem, we propose a novel end-to-end deep neural network that explicitly models highly discriminative signer-independent latent representations from the input data. The key idea of our model is to learn a distribution over latent representations, conditionally independent of signer identity. Accordingly, the learned latent representations will preserve as much information as possible about the signs, and discard signer-specific traits that are irrelevant for recognition. By imposing such regularization in the representation space, the result is a truly signer-independent model which is robust to different and new test signers. The experimental results demonstrate the effectiveness of the proposed model in several SLR databases. [ABSTRACT FROM AUTHOR]

A noise detection system (INDS) composed of an acoustic triboelectric nano-generator (TENG) and an electrical bilayer synaptic transistor (EDLT) is proposed. As a self-powered sound sensor, TENG converts the sound signal directly into a voltage signal output. EDLT is used as a neuromorphic device to simulate synaptic behavior in organisms and has the ability to store and process signals simultaneously. In this letter, a kind of intelligent, simple structure and humanized noise detection system is developed. [ABSTRACT FROM AUTHOR]

Primary cilia are evolutionarily conserved and highly specialized organelles that protrude from cell membranes. Mutations in genes encoding ciliary proteins can cause structural and functional ciliary defects and consequently multiple diseases, collectively termed ciliopathies. The mammalian auditory system is responsible for perceiving external sound stimuli that are ultimately processed in the brain through a series of physical and biochemical reactions. Here we review the structure and function of the specialized primary cilia of hair cells, termed kinocilia, found in the mammalian auditory system. We also discuss areas that might prove amenable for therapeutic management of auditory ciliopathies.

The inferior colliculus (IC), the midbrain hub of the central auditory system, receives extensive cholinergic input from the pontomesencephalic tegmentum. Activation of nicotinic acetylcholine receptors (nAChRs) in the IC can alter acoustic processing and enhance auditory task performance. However, how nAChRs affect the excitability of specific classes of IC neurons remains unknown. Recently, we identified vasoactive intestinal peptide (VIP) neurons as a distinct class of glutamatergic principal neurons in the IC. Here, in experiments using male and female mice, we show that cholinergic terminals are routinely located adjacent to the somas and dendrites of VIP neurons. Using whole-cell electrophysiology in brain slices, we found that acetylcholine drives surprisingly strong and long-lasting excitation and inward currents in VIP neurons. This excitation was unaffected by the muscarinic receptor antagonist atropine. Application of nAChR antagonists revealed that acetylcholine excites VIP neurons mainly via activation of α3β4∗ nAChRs, a nAChR subtype that is rare in the brain. Furthermore, we show that acetylcholine excites VIP neurons directly and does not require intermediate activation of presynaptic inputs that might express nAChRs. Lastly, we found that low frequency trains of acetylcholine puffs elicited temporal summation in VIP neurons, suggesting that in vivo-like patterns of cholinergic input can reshape activity for prolonged periods. These results reveal the first cellular mechanisms of nAChR regulation in the IC, identify a functional role for α3β4∗ nAChRs in the auditory system, and suggest that cholinergic input can potently influence auditory processing by increasing excitability in VIP neurons and their postsynaptic targets.

Congenital hypothyroidism (CH) is an endocrine disease commonly found in newborns and is related to the absence or reduction of thyroid hormones (THs), which are essential for development since intrauterine life. Children with CH can develop hearing problems as THs are crucial for the auditory pathway’s development and maturation. Sensory deprivations, especially in hearing disorders at early ages of development, can impair language skills, literacy, and behavioral, cognitive, social, and psychosocial development. In this review we describe clinical and molecular aspects linking CH and hearing loss.

The auditory system is sensitive to stimulus regularities such as frequently occurring sounds and sound combinations. Evidence of regularity detection can be seen in how neurons across the auditory network, from brainstem to cortex, respond to the statistical properties of the soundscape, and in the rapid learning of recurring patterns in their environment by children and adults. Although rapid auditory learning is presumed to involve functional changes to the auditory network, the chronology and directionality of changes are not well understood. To study the mechanisms by which this learning occurs, auditory brainstem and cortical activity was simultaneously recorded via electroencephalogram (EEG) while young adults listened to novel sound streams containing recurring patterns. Neurophysiological responses were compared between easier and harder learning conditions. Collectively, the behavioral and neurophysiological findings suggest that cortical and subcortical structures each provide distinct contributions to auditory pattern learning, but that cortical sensitivity to stimulus patterns likely precedes subcortical sensitivity.

Previous studies have provided evidence about the brain plasticity effects of musical training, however, the issue of how expertise in music styles induced by Chinese or Western musical training affects neuroplasticity and reward responses has been less considered, especially for subjects of Chinese origin. In this work, 16 musicians who trained in the Western music style (Western-trained musicians) and 18 musicians who trained in the Chinese music style (Chinese-trained musicians) were recruited as the musician group for the experiment, while 15 non-musicians were recruited as the control group. Using a paradigm that consisted of listening to Chinese and Western music and measurements using functional magnetic resonance imaging (fMRI) technology, we found that Chinese-trained musicians activated the bilateral superior temporal gyrus (STG) when listening to music, while Western-trained musicians activated the left STG. In addition, under the condition of listening to music with Chinese style, Chinese-trained musicians have a stronger functional connection in the circuit of the auditory and reward system than Western-trained musicians. The finding is opposite under the condition of listening to music with Western style. Interestingly, it seems that the circuit of Chinese-trained musicians is partial to the right STG, while Western-trained musicians show the opposite, i.e., a tendency toward the left STG. The influence of different music styles on experienced musicians is reflected by the functional activities and connections between the auditory system and the reward system. This outcome indicates that training in Chinese music style or Western music style affects the strategies of musicians when listening to music. Musical characteristics such as rhythm, melody and cultural attributes play an important role in this process. These findings, which provide evidence for functional neuroplasticity based on musical training, can enrich our insights into the musical brain.

This study was to investigate whether human listeners are able to detect a binaurally uncorrelated arbitrary-noise fragment embedded in binaurally identical arbitrary-noise markers [a break in correlation, break in interaural correlation (BIAC)] in either frequency-constant (frequency-steady) or frequency-varied (unidirectionally frequency gliding) noise. Ten participants with normal hearing were tested in Experiment 1 for up-gliding, down-gliding, and frequency-steady noises. Twenty-one participants with normal hearing were tested in Experiment 2a for both up-gliding and frequency-steady noises. Another nineteen participants with normal hearing were tested in Experiment 2b for both down-gliding and frequency-steady noises. Listeners were able to detect a BIAC in the frequency-steady noise (center frequency = 400 Hz) and two types of frequency-gliding noises (center frequency: between 100 and 1,600 Hz). The duration threshold for detecting the BIAC in frequency-gliding noises was significantly longer than that in the frequency-steady noise (Experiment 1), and the longest interaural delay at which a duration-fixed BIAC (200 ms) in frequency-gliding noises could be detected was significantly shorter than that in the frequency-steady noise (Experiment 2). Although human listeners can detect a BIAC in frequency-gliding noises, their sensitivity to a BIAC in frequency-gliding noises is much lower than that in frequency-steady noise.

The auditory system is sensitive to stimulus regularities such as frequently occurring sounds and sound combinations. Evidence of regularity detection can be seen in how neurons across the auditory network, from brainstem to cortex, respond to the statistical properties of the soundscape, and in the rapid learning of recurring patterns in their environment by children and adults. Although rapid auditory learning is presumed to involve functional changes to the auditory network, the chronology and directionality of changes are not well understood. To study the mechanisms by which this learning occurs, auditory brainstem and cortical activity was simultaneously recorded via electroencephalogram (EEG) while young adults listened to novel sound streams containing recurring patterns. Neurophysiological responses were compared between easier and harder learning conditions. Collectively, the behavioral and neurophysiological findings suggest that cortical and subcortical structures each provide distinct contributions to auditory pattern learning, but that cortical sensitivity to stimulus patterns likely precedes subcortical sensitivity. [ABSTRACT FROM AUTHOR]

Congenital hypothyroidism (CH) is an endocrine disease commonly found in newborns and is related to the absence or reduction of thyroid hormones (THs), which are essential for development since intrauterine life. Children with CH can develop hearing problems as THs are crucial for the auditory pathway's development and maturation. Sensory deprivations, especially in hearing disorders at early ages of development, can impair language skills, literacy, and behavioral, cognitive, social, and psychosocial development. In this review we describe clinical and molecular aspects linking CH and hearing loss. [ABSTRACT FROM AUTHOR]

The inferior colliculus (IC), the midbrain hub of the central auditory system, receives extensive cholinergic input from the pontomesencephalic tegmentum. Activation of nicotinic acetylcholine receptors (nAChRs) in the IC can alter acoustic processing and enhance auditory task performance. However, how nAChRs affect the excitability of specific classes of IC neurons remains unknown. Recently, we identified vasoactive intestinal peptide (VIP) neurons as a distinct class of glutamatergic principal neurons in the IC. Here, in experiments using male and female mice, we show that cholinergic terminals are routinely located adjacent to the somas and dendrites of VIP neurons. Using whole-cell electrophysiology in brain slices, we found that acetylcholine drives surprisingly strong and long-lasting excitation and inward currents in VIP neurons. This excitation was unaffected by the muscarinic receptor antagonist atropine. Application of nAChR antagonists revealed that acetylcholine excites VIP neurons mainly via activation of α3β4∗ nAChRs, a nAChR subtype that is rare in the brain. Furthermore, we show that acetylcholine excites VIP neurons directly and does not require intermediate activation of presynaptic inputs that might express nAChRs. Lastly, we found that low frequency trains of acetylcholine puffs elicited temporal summation in VIP neurons, suggesting that in vivo -like patterns of cholinergic input can reshape activity for prolonged periods. These results reveal the first cellular mechanisms of nAChR regulation in the IC, identify a functional role for α3β4∗ nAChRs in the auditory system, and suggest that cholinergic input can potently influence auditory processing by increasing excitability in VIP neurons and their postsynaptic targets. [ABSTRACT FROM AUTHOR]

The dorsal cochlear nucleus (DCN) is a mammalian‐specific nucleus of the auditory system. Anatomically, it is classified as a cerebellum‐like structure. These structures are proposed to share genetic programs with the cerebellum. Previous analyses demonstrated that inhibitory serial sister cell types (SCTs) of the DCN and cerebellum are derived from the pancreatic transcription factor 1a (Ptf1a) lineage. Postmitotic neurons of the Ptf1a lineage often express the transcription factor Ladybird homeobox protein homolog 1 (Lbx1) which is involved in neuronal cell fate determination. Lbx1 is therefore an attractive candidate for a further component of the genetic program shared between the DCN and cerebellum. Here, we used cell‐type specific marker analysis in combination with an Lbx1 reporter mouse line to analyze in both tissues which cell types of the Ptf1a lineage express Lbx1. In the DCN, stellate cells and Purkinje‐like cartwheel cells were part of the Lbx1 lineage and Golgi cells were not, as determined by cell counts. In contrast, in the cerebellum, stellate cells and Golgi cells were part of the Lbx1 lineage and Purkinje cells were not. Hence, two out of three phenotypically similar cell types differed with respect to their Lbx1 expression. Our study demonstrates that Lbx1 is differentially recruited to the developmental genetic program of inhibitory neurons both within a given tissue and between the DCN and cerebellum. The differential expression of Lbx1 within the DCN and the cerebellum might contribute to the genetic individuation of the inhibitory SCTs to adapt to circuit specific tasks. [ABSTRACT FROM AUTHOR]

Previous studies have provided evidence about the brain plasticity effects of musical training, however, the issue of how expertise in music styles induced by Chinese or Western musical training affects neuroplasticity and reward responses has been less considered, especially for subjects of Chinese origin. In this work, 16 musicians who trained in the Western music style (Western-trained musicians) and 18 musicians who trained in the Chinese music style (Chinese-trained musicians) were recruited as the musician group for the experiment, while 15 non-musicians were recruited as the control group. Using a paradigm that consisted of listening to Chinese and Western music and measurements using functional magnetic resonance imaging (fMRI) technology, we found that Chinese-trained musicians activated the bilateral superior temporal gyrus (STG) when listening to music, while Western-trained musicians activated the left STG. In addition, under the condition of listening to music with Chinese style, Chinese-trained musicians have a stronger functional connection in the circuit of the auditory and reward system than Western-trained musicians. The finding is opposite under the condition of listening to music with Western style. Interestingly, it seems that the circuit of Chinese-trained musicians is partial to the right STG, while Western-trained musicians show the opposite, i.e., a tendency toward the left STG. The influence of different music styles on experienced musicians is reflected by the functional activities and connections between the auditory system and the reward system. This outcome indicates that training in Chinese music style or Western music style affects the strategies of musicians when listening to music. Musical characteristics such as rhythm, melody and cultural attributes play an important role in this process. These findings, which provide evidence for functional neuroplasticity based on musical training, can enrich our insights into the musical brain. [ABSTRACT FROM AUTHOR]

Objective: This work aims to reduce the acoustic noise level of transcranial magnetic stimulation (TMS) coils. TMS requires high currents (several thousand amperes) to be pulsed through the coil, which generates a loud acoustic impulse whose peak sound pressure level (SPL) can exceed 130 dB(Z). This sound poses a risk to hearing and elicits unwanted neural activation of auditory brain circuits. Methods: We propose a new double-containment coil with enhanced winding mounting (DCC), which utilizes acoustic impedance mismatch to contain and dissipate the impulsive sound within an air-tight outer casing. The coil winding is potted into a rigid block, which is mounted to the outer casing through the block´s acoustic nodes that are subject to minimum vibration during the pulse. The rest of the winding block is isolated from the casing by an air gap, and the sound is absorbed by polyester fiber panels within the casing. The casing thickness under the winding center is minimized to maximize the electric field output. Results: Compared to commercial figure-of-eight TMS coils, the DCC prototype has 18–41 dB(Z) lower peak SPL at matched stimulation strength, whilst providing 28% higher maximum stimulation strength than equally focal coils. Conclusion: The DCC design greatly reduces the acoustic noise of TMS while increasing the achievable stimulation strength. Significance: The acoustic noise reduction from our coil design is comparable to that provided by typical hearing protection devices. This coil design approach can enhance hearing safety and reduce auditory co-activations in the brain and other detrimental effects of TMS sound. [ABSTRACT FROM AUTHOR]

The song system of songbirds (oscines) is one of the best studied neuroethological model systems. So far, it has been treated as a relatively constrained sensorimotor system. Songbirds such as crows, however, are also known for their capability to cognitively control their audio‐vocal system. Yet, the neuroanatomy of the corvid song system has never been explored systematically. We aim to close this scientific gap by presenting a stereotactic investigation of the extended song system of the carrion crow (Corvus corone), an oscine songbird of the corvid family that has become an interesting model system for cognitive neuroscience. In order to identify and delineate the song nuclei, the ascending auditory nuclei, and the descending vocal‐motor nuclei, four stains were applied. In addition to the classical Nissl‐, myelin‐, and a combination of Nissl‐and‐myelin staining, staining for tyrosine hydroxylase was used to reveal the distribution of catecholaminergic neurons (dopaminergic, noradrenergic, and adrenergic) in the song system. We show that the crow brain contains the important song‐related nuclei, including auditory input and motor output structures, and map them throughout the brain. Fiber‐stained sections reveal putative connection patterns between the crow's song nuclei comparable to other songbirds. [ABSTRACT FROM AUTHOR]

People suffering from hearing impairment often have difficulties participating in conversations in so-called cocktail party scenarios where multiple individuals are simultaneously talking. Although advanced algorithms exist to suppress background noise in these situations, a hearing device also needs information about which speaker a user actually aims to attend to. The voice of the correct (attended) speaker can then be enhanced through this information, and all other speakers can be treated as background noise. Recent neuroscientific advances have shown that it is possible to determine the focus of auditory attention through noninvasive neurorecording techniques, such as electroencephalography (EEG). Based on these insights, a multitude of auditory attention decoding (AAD) algorithms has been proposed, which could, combined with appropriate speaker separation algorithms and miniaturized EEG sensors, lead to so-called neurosteered hearing devices. In this article, we provide a broad review and a statistically grounded comparative study of EEG-based AAD algorithms and address the main signal processing challenges in this field. [ABSTRACT FROM AUTHOR]

Three cochlear implant (CI) sound coding strategies were combined in the same signal processing path and compared for speech intelligibility with vocoded Mandarin sentences. The three CI coding strategies, biologically-inspired hearing aid algorithm (BioAid), envelope enhancement (EE), and fundamental frequency modulation (F0mod), were combined with the advanced combination encoder (ACE) strategy. Hence, four singular coding strategies and four combinational coding strategies were derived. Mandarin sentences with speech-shape noise were processed using these coding strategies. Speech understanding of vocoded Mandarin sentences was evaluated using short-time objective intelligibility (STOI) and subjective sentence recognition tests with normal-hearing listeners. For signal-to-noise ratios at 5 dB or above, the EE strategy had slightly higher average scores in both STOI and listening tests compared to ACE. The addition of EE to BioAid slightly increased the mean scores for BioAid+EE, which was the combination strategy with the highest scores in both objective and subjective speech intelligibility. The benefits of BioAid, F0mod, and the four combinational coding strategies were not observed in CI simulation. The findings of this study may be useful for the future design of coding strategies and related studies with Mandarin. [ABSTRACT FROM AUTHOR]

This study was to investigate whether human listeners are able to detect a binaurally uncorrelated arbitrary-noise fragment embedded in binaurally identical arbitrary-noise markers [a break in correlation, break in interaural correlation (BIAC)] in either frequency-constant (frequency-steady) or frequency-varied (unidirectionally frequency gliding) noise. Ten participants with normal hearing were tested in Experiment 1 for up-gliding, down-gliding, and frequency-steady noises. Twenty-one participants with normal hearing were tested in Experiment 2a for both up-gliding and frequency-steady noises. Another nineteen participants with normal hearing were tested in Experiment 2b for both down-gliding and frequency-steady noises. Listeners were able to detect a BIAC in the frequency-steady noise (center frequency = 400 Hz) and two types of frequency-gliding noises (center frequency: between 100 and 1,600 Hz). The duration threshold for detecting the BIAC in frequency-gliding noises was significantly longer than that in the frequency-steady noise (Experiment 1), and the longest interaural delay at which a duration-fixed BIAC (200 ms) in frequency-gliding noises could be detected was significantly shorter than that in the frequency-steady noise (Experiment 2). Although human listeners can detect a BIAC in frequency-gliding noises, their sensitivity to a BIAC in frequency-gliding noises is much lower than that in frequency-steady noise. [ABSTRACT FROM AUTHOR]

The harriers (Accipitridae: Circus) represent a unique group of raptorial birds due to their hunting behaviour and their facial ruff and prominent facial disc. During previous studies it was suggested that harrier species may have other convergent features shared with owls like asymmetric or enlarged ear openings related to sensitive hearing capabilities. In this study, cranial asymmetry was done using SAGE (Symmetry and Asymmetry of Geometric Data) software. 32 skulls of 3 species (Western Marsh Harrier (Circus aeruginosus) n=8, Montagu's Harrier (Circus pygargus) n=10, Hen Harrier (Circus cyaneus) n=14) were photographed, digitized and assigned with 2D landmarks with TpsDig software. The variables were analysed based on Generalized Procrustes analysis. The morphometric data showed cranial asymmetry of harriers. This asymmetry should rather be explained by foraging strategies as the results are corresponding to the exceptionally good hearing of these species among diurnal raptors. [ABSTRACT FROM AUTHOR]

Most infants who are later diagnosed with autism show delayed speech and language and/or atypical language profile. There is a large body of research on abnormal speech and language in children with autism. However, auditory development has been relatively under-investigated in autism research, despite its inextricable relationship with language development and despite researchers' ability to detect abnormalities in brain development and behavior in early infancy. In this review, we synthesize research on auditory processing in the prenatal period through infancy and childhood in typically developing children, children at high risk for autism, and children diagnosed with autism. We conclude that there are clear neurobiological and behavioral links between abnormal auditory development and the deficits in social communication seen in autism. We then offer perspectives on the need for a systematic characterization of early auditory development in autism, and identified questions to be addressed in future research on the development of autism. [ABSTRACT FROM AUTHOR]

Excessive noise exposure presents significant health risks to humans, affecting not just the auditory system but also the cardiovascular and central nervous systems. This study focused on three male macaque monkeys as subjects. 90 dB sound pressure level (SPL) pure tone exposure (frequency: 500Hz, repetition rate: 40Hz, 1 min per day, continuously exposed for 5 days) was administered. Assessments were performed before exposure, during exposure, immediately after exposure, and at 7-, 14-, and 28-days post-exposure, employing auditory brainstem response (ABR) tests, electrocardiograms (ECG), and electroencephalograms (EEG). The study found that the average threshold for the Ⅴ wave in the right ear increased by around 30 dB SPL right after exposure (P < 0.01) compared to pre-exposure. This elevation returned to normal within 7 days. The ECG results indicated that one of the macaque monkeys exhibited an RS-type QRS wave, and inverted T waves from immediately after exposure to 14 days, which normalized at 28 days. The other two monkeys showed no significant changes in their ECG parameters. Changes in EEG parameters demonstrated that main brain regions exhibited significant activation at 40Hz during noise exposure. After noise exposure, the power spectral density (PSD) in main brain regions, particularly those represented by the temporal lobe, exhibited a decreasing trend across all frequency bands, with no clear recovery over time. In summary, exposure to 90 dB SPL noise results in impaired auditory systems, aberrant brain functionality, and abnormal electrocardiographic indicators, albeit with individual variations. It has implications for establishing noise protection standards, although the precise mechanisms require further exploration by integrating pathological and behavioral indicators. • 90 dB pure tone exposure results in transient hearing threshold shifts. • Electrocardiogram following exposure to 90 dB pure tone among the three macaques exhibit individual differences, reflecting individual variations in their ability to cope with and compensate for external stress stimuli. • Nervous system dysfunction is evidenced by disrupted power spectral density of resting-state electroencephalogram across multiple frequency bands throughout the brain. • The pure tone exposure of 40 Hz repetition frequency significantly activates the electroencephalogram signals at the same frequency in main brain regions. [ABSTRACT FROM AUTHOR]

Keywords: auditory system; electrophysiology; neurotology; synaptic plasticity EN auditory system electrophysiology neurotology synaptic plasticity 3653 3655 3 08/17/22 20220815 NES 220815 Introduction The auditory system consists of a sophisticated balance of ascending and descending auditory signals that enable mammals to respond to stimuli of varying magnitude, adjust auditory gain and respond appropriately to saliency. To increase understanding of MOC neuron activity throughout the course of auditory stimuli, Torres Cadenas and colleagues investigated the short-term plasticity of the MNTB-MOC synapse. Taking a transgenic approach, the authors were able to isolate MOC neurons and adjust physiological parameters affecting neurotransmitter release and firing frequency of MNTB neurons. [Extracted from the article]

Auditory brainstem networks facilitate sound source localization through binaural integration. A key component of this circuitry is the projection from the ventral cochlear nucleus (VCN) to the medial nucleus of the trapezoid body (MNTB), a relay nucleus that provides inhibition to the superior olivary complex. This strictly contralateral projection terminates in the large calyx of Held synapse. The formation of this pathway requires spatiotemporal coordination of cues that promote cell maturation, axon growth, and synaptogenesis. Here we have examined the emergence of distinct classes of glial cells, which are known to function in development and in response to injury. Immunofluorescence for several astrocyte markers revealed unique expression patterns. Aldehyde dehydrogenase 1 family member L1 (ALDH1L1) was expressed earliest in both nuclei, followed by S100ß, during the first postnatal week. Glial fibrillary acidic protein (GFAP) expression was seen in the second postnatal week. GFAP-positive cell bodies remained outside the boundaries of VCN and MNTB, with a limited number of labeled fibers penetrating into the margins of the nuclei. Oligodendrocyte transcription factor 2 (OLIG2) expression revealed the presence of oligodendrocytes in VCN and MNTB from birth until after hearing onset. In addition, ionized calcium binding adaptor molecule 1 (IBA1)-positive microglia were observed after the first postnatal week. Following hearing onset, all glial populations were found in MNTB. We then determined the distribution of glial cells following early (P2) unilateral cochlear removal, which results in formation of ectopic projections from the intact VCN to ipsilateral MNTB. We found that following perturbation, astrocytic markers showed expression near the ectopic ipsilateral calyx. Taken together, the developmental expression patterns are consistent with a role for glial cells in the maturation of the calyx of Held and suggest that these cells may have a similar role in maturation of lesion-induced connections.

The use of a craniotomy for in vivo experiments provides an opportunity to investigate the dynamics of diverse cellular processes in the mammalian brain in adulthood and during development. Although most in vivo approaches use a craniotomy to study brain regions located on the dorsal side, brainstem regions such as the pons, located on the ventral side remain relatively understudied. The main goal of this protocol is to facilitate access to ventral brainstem structures so that they can be studied in vivo using electrophysiological and imaging methods. This approach allows study of structural changes in long-range axons, patterns of electrical activity in single and ensembles of cells, and changes in blood brain barrier permeability in neonate animals. Although this protocol has been used mostly to study the auditory brainstem in neonate rats, it can easily be adapted for studies in other rodent species such as neonate mice, adult rodents and other brainstem regions.

Abstract In this paper, an adaptive averaging a priori SNR estimation employing critical band processing is proposed. The proposed method modifies the current decision-directed a priori SNR estimation to achieve faster tracking when SNR changes. The decision-directed estimator (DD) employs a fixed weighting with the value close to one, which makes it slow in following the onsets of speech utterances. The proposed SNR estimator provides a means to solve this issue by employing an adaptive weighting factor. This allows an improved tracking of onset changes in the speech signal. As a consequence, it results in better preservation of speech components. This adaptive technique ensures that the weighting between the modified decision-directed a priori estimate and the maximum likelihood a priori estimate is a function of the speech absence probability. The estimate of the speech absence probability is modeled by a sigmoid function. Furthermore, a critical band mapping for the short-time Fourier transform analysis-synthesis system is utilized in the speech enhancement to achieve less musical noise. In addition, to evaluate the ability of the a priori SNR estimation method in preserving speech components, we proposed a modified objective measurement known as modified hamming distance. Evaluations are performed by utilizing both objective and subjective measurements. The experimental results show that the proposed method improves the speech quality under different noise conditions. Moreover, it maintains the advantage of the DD approach in eliminating the musical noise under different SNR conditions. The objective results are supported by subjective listening tests using 10 subjects (5 males and 5 females).

The mechanisms that govern thalamocortical transmission are poorly understood. Recent data have shown that sensory stimuli elicit activity in ensembles of cortical neurons that recapitulate stereotyped spontaneous activity patterns. Here, we elucidate a possible mechanism by which gating of patterned population cortical activity occurs. In this study, sensory-evoked all-or-none cortical population responses were observed in the mouse auditory cortex in vivo and similar stochastic cortical responses were observed in a colliculo-thalamocortical brain slice preparation. Cortical responses were associated with decreases in auditory thalamic synaptic inhibition and increases in thalamic synchrony. Silencing of corticothalamic neurons in layer 6 (but not layer 5) or the thalamic reticular nucleus linearized the cortical responses, suggesting that layer 6 corticothalamic feedback via the thalamic reticular nucleus was responsible for gating stochastic cortical population responses. These data implicate a corticothalamic-thalamic reticular nucleus circuit that modifies thalamic neuronal synchronization to recruit populations of cortical neurons for sensory representations.

Dopamine (DA) modulates the activity of nuclei within the ascending and descending auditory pathway. Previous studies have identified neurons and fibers in the inferior colliculus (IC) which are positively labeled for tyrosine hydroxylase (TH), a key enzyme in the synthesis of dopamine. However, the origins of the tyrosine hydroxylase positive projections to the inferior colliculus have not been fully explored. The lateral lemniscus (LL) provides a robust inhibitory projection to the inferior colliculus and plays a role in the temporal processing of sound. In the present study, immunoreactivity for tyrosine hydroxylase was examined in animals with and without 6-hydroxydopamine (6-OHDA) lesions. Lesioning, with 6-OHDA placed in the inferior colliculus, led to a significant reduction in tyrosine hydroxylase immuno-positive labeling in the lateral lemniscus and inferior colliculus. Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated. Very little immunoreactivity for DBH and no immunoreactivity for PNMT was found within the cell bodies of the dorsal, intermediate, or ventral nucleus of the lateral lemniscus. The results indicate that catecholaminergic neurons of the lateral lemniscus are likely dopaminergic and not noradrenergic or adrenergic. Next, high-pressure liquid chromatography (HPLC) analysis was used to confirm that dopamine is present in the inferior colliculus and nuclei that send projections to the inferior colliculus, including the cochlear nucleus (CN), superior olivary complex (SOC), lateral lemniscus, and auditory cortex (AC). Finally, fluorogold, a retrograde tracer, was injected into the inferior colliculus of adult rats. Each subdivision of the lateral lemniscus contained fluorogold within the somata, with the dorsal nucleus of the lateral lemniscus showing the most robust projections to the inferior colliculus. Fluorogold-tyrosine hydroxylase colocalization within the lateral lemniscus was assessed. The dorsal and intermediate nuclei neurons exhibiting similar degrees of colocalization, while neurons of the ventral nucleus had significantly fewer colocalized fluorogold-tyrosine hydroxylase labeled neurons. These results suggest that several auditory nuclei that project to the inferior colliculus contain dopamine, dopaminergic neurons in the lateral lemniscus project to the inferior colliculus and that dopaminergic neurotransmission is poised to play a pivotal role in the function of the inferior colliculus.