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The NCEP reanalysis data were utilized to diagnose the structural characteristics and evolutionary mechanisms of two plateau vortex processes that moved eastward out of the plateau on June 25-27， 2008 and June 4-10， 2013.The data were also used to explore the structural characteristics of the two long and short track plateau vortex processes and the influencing factors that caused their different life histories.The results show that： （1） During the Zhaduo vortex activity with a short path， the South Asian high pressure is flattened， the upper-level jet stream is southward and the plateau vortex moves out of the plateau in the slump trough.During the Qumalai vortex activity with a long path， the South Asian high pressure has a north arch， the plateau vortex is in the northwest airflow under the South Asian high-pressure ridge， the subtropical high is southward and the plateau vortex is strengthened with the eastward movement of the trough， accompanied by the eastward movement of the southwest vortex.（2） The two plateau vortex processes exhibit distinct structural characteristics， especially when the Zhaduo vortex is strengthened on the plateau and when the Qumalai vortex is strengthened again after coupling with the southwest vortex.The former vortex is in the deeper positive vorticity and upward motion layer at 600~350 hPa and also has the structural characteristics of strong divergence in the upper troposphere.The latter has the structural characteristics of high， middle， and low positive vorticity penetration in the troposphere， ascending movement in the troposphere， and weak divergence in the troposphere.（3） The diagnosis of total vorticity budget shows that the change of divergence term plays a decisive role in the change of total vorticity variability of low vortices.The strength change of Zhaduo vortex is consistent with the divergence term change.The influence of vertical transport term and horizontal advection term are strengthened during the accompaniment of Qumalai vortex with the southwest vortex.（4） Regarding the budget analysis of the 500 hPa positive vorticity variability in the central region of the vortex， the results show that when there is no activity of the southwest vortex， the plateau vortex contributes mainly to the 500 hPa positive vorticity variability of the plateau vortex due to convergence.When there is activity of the southwest vortex， the vertical transport of positive vorticity becomes more important with the superposition and companionship with the southwest vortex in the vertical direction.

Embedded computer vision systems are increasingly being adopted across various domains, playing a pivotal role in enabling advanced technologies such as autonomous vehicles and industrial automation. Their cost-effectiveness, compact size, and portability make them particularly well-suited for diverse implementations and operations. In real-time scenarios, these systems must process visual data with minimal latency, which is crucial for immediate decision-making. However, these solutions continue to face significant challenges related to computational efficiency, memory usage, and accuracy. This research addresses these challenges by enhancing classification methodologies, specifically in Gray Level Co-occurrence Matrix (GLCM) feature extraction and Support Vector Machine (SVM) classifiers. To maintain a high level of accuracy while preserving performance, a smaller feature set is selected following a comprehensive complexity analysis and is further refined through Correlation-based Feature Selection (CFS). The proposed method achieves an overall classification accuracy of 84.76% with a feature set reduced by 79.2%, resulting in a 72.45% decrease in processing time, a 50% reduction in storage requirements, and up to a 77.8% decrease in memory demand during prediction. These improvements demonstrate the effectiveness of the proposed approach in improving the adaptability and capabilities of embedded vision systems (EVS), optimizing their performance under the constraints of real-time limited-resource environments.

This study examined the survival rates of Anadara broughtonii and Chlamys farreri with varying heights throughout winter and summer aquaculture periods under varying ratios of mixed-culture conditions in marine environments. The aim was to assess the viability and economic advantages of mixed-culture practices among different bivalve species. Results indicate that the winter (from December to February of the following year) mortality rate for A. broughtonii in mixed culture ranges from 12.04% to 16.85%, markedly lower than in single-species cultures. Mixed-culture A. broughtonii measuring 2.5–4.0 cm exhibit a significantly reduced summer (from July to September) mortality rate compared to those in single-species cultures (p < 0.05). No significant mortality difference was observed between the monoculture and polyculture of C. farreri. Growth rates of C. farreri and A. broughtonii showed no significant differences between monoculture and polyculture conditions. The optimal size for combining two different species of bivalves is 2.5 cm, with a 1:1 ratio being the most effective. An equal number of seedlings were cultivated across various seawater aquaculture systems for a period of one year. The survival rates of monoculture seedlings of Anadara broughtonii and Chlamys farreri were 60.34% and 86.55%, respectively. In contrast, polyculture seedlings exhibited higher survival rates after one year of mariculture, with Anadara broughtonii at 73.36% and Chlamys farreri at 89.74%. The polyculture of A. broughtonii and C. farreri in suspension cages demonstrates a favorable input–output ratio of 1:2.02. This approach effectively reduces winter and summer mortality rates of A. broughtonii, representing an efficient new method for marine bivalve aquaculture.

Research on Higher Education (HE) documents a plethora of applicable teaching practices and improvements focused on better instructional planning. Yet, what happens when carefully crafted plans must be abandoned due to something unforeseen? This study documents teaching situations when things do not work as expected, where moments of breakdown alter a planned pedagogical course of action. Analysing these moments and their aftermath directs attention to empirical events rendering visible some overlooked, but revealing aspects of HE teaching. We conducted a qualitative study into the characteristics of breakdowns and how teachers handle such situations. University teachers from different disciplinary backgrounds and academic positions were interviewed about teaching experiences they found challenging. From our nine semi-structured interviews, three were selected for this paper. Inspired by methodology from Science and Technology Studies (STS), breakdowns are theorised as analytically generative moments for understanding ways in which technology, subject knowledge, and teacher-student relations, are intertwined. We offer terminology for discussing breakdowns and how elements of teaching practice can transmute and recombine into novel forms of practice. The study provides evidence relating to how breakdowns manifested in multiple ways, and despite abruptness and threats of disjointedness, gave rise to improved interaction, methodological development, and long-term learning. Three key phases are identified: breakdown, remobilisation and re-stabilisation. Further, rendered visible are ways in which teaching relies on material complexities and interdependencies. Breakdowns were sources of trouble, tension, and discouragement, but also facilitated instructional creativity opening space for unanticipated and inventive approaches to teaching (breakthroughs).

IMPORTANCE:. To explore the correlation between cortisol levels during first admission day and clinical outcomes. OBJECTIVES:. Although most patients exhibit a surge in cortisol levels in response to stress, some suffer from critical illness-related corticosteroid insufficiency (CIRCI). Literature remains inconclusive as to which of these patients are at greater risk of poor outcomes. DESIGN:. A retrospective study. SETTING:. A surgical ICU (SICU) in a tertiary medical center. PARTICIPANTS:. Critically ill patients admitted to the SICU who were not treated with steroids. MAIN OUTCOMES AND MEASURES:. Levels of cortisol taken within 24 hours of admission (day 1 [D1] cortisol) in 1412 eligible patients were collected and analyzed. Results were categorized into four groups: low (0–10 µg/dL), normal (10–25 µg/dL), high (25–50 µg/dL), and very high (above 50 µg/dL) cortisol levels. Primary endpoint was 90-day mortality. Secondary endpoints were the need for organ support (use of vasopressors and mechanical ventilation [MV]), ICU length of stay (LOS), and duration of MV. RESULTS:. The majority of patients (63%) had high or very high D1 cortisol levels, whereas 7.6% had low levels and thus could be diagnosed with CIRCI. There were statistically significant differences in 90-day mortality between the four groups and very high levels were found to be an independent risk factor for mortality, primarily in patients with Sequential Organ Failure Assessment (SOFA) less than or equal to 3 or SOFA greater than or equal to 7. Higher cortisol levels were associated with all secondary endpoints. CIRCI was associated with favorable outcomes. CONCLUSIONS AND RELEVANCE:. In critically ill surgical patients D1 cortisol levels above 50 mcg/dL were associated with mortality, need for organ support, longer ICU LOS, and duration of MV, whereas low levels correlated with good clinical outcomes even though untreated. D1 cortisol level greater than 50 mcg/dL can help discriminate nonsurvivors from survivors when SOFA less than or equal to 3 or SOFA greater than or equal to 7.

Abstract Over the past several decades, major efforts have been directed toward the optimization of carrier concentrations to maximize thermoelectric performance. Chemical doping is an effective way to control carriers, but electrostatic gating provides a continuous tuning knob that enables effective and dynamic changes to the carrier density. Here, a method is reported that uses an electric‐double‐layer (EDL) transistor‐based ionic liquids gating to adjust the thermoelectric properties of thin films made from Nb‐doped SrTiO3 (Nb‐STO). This technique allows us to effectively change these properties at room temperature by varying the concentration of charge carriers within a broad range. A combination of lower film thickness and intrinsic carrier concentration leads to an enhanced ionic liquid‐gated response, resulting in an 18‐fold enhancement in power factor at room temperature for a 14 nm thin 4% Nb‐STO film at gate voltages within ±3.0 V. The present study offers new insights and strategies toward enhanced gate tunable thermoelectric properties in thin films.

Dental caries is multifactorial and polymicrobial in nature and remains one of the most common oral diseases. While caries research has focused on Streptococcus mutans as the main etiological pathogen, its impact at the tooth level is not fully understood. In this cross-sectional study, the levels and distribution of S. mutans in the posterior teeth at different dentition stages were investigated along with the corresponding tooth-specific microbiome. Occlusal plaque samples of 87 individual posterior teeth were collected from thirty children in three dentition stages (primary, mixed, and permanent). The S. mutans levels in the occlusal plaque of individual posterior teeth were quantified with qPCR, and those with preferential colonization were selected for tooth-specific microbiome analysis using 16S rRNA sequencing. Results: Quantification of S. mutans levels in the occlusal plaque confirmed the preferential colonization on the first primary and permanent molars. These teeth were selected for further tooth-specific microbiome sequencing, as they also displayed high caries experience. There were significant differences in the relative abundance of the four most abundant genera: Neisseria, Streptococcus, Rothia, and Veillonella. Furthermore, the tooth-level caries experience was correlated with a reduction in the microbiome diversity. Analyzing the different tooth-associated microbial communities, distinct tooth-specific core microbiomes were identified. Conclusions: Our findings suggest that caries susceptibility at the tooth level, depending on tooth type and dentition stage, is influenced by individual species as well as plaque community.

Penderitaan akibat kanker adalah masalah yang signifikan di seluruh dunia, dengan angka kasus baru yang terus meningkat setiap tahun. Penderita kanker sering menghadapi tantangan fisik, psikologis, dan emosional yang kompleks selama perjalanan penyakit mereka. Regulasi emosi dan resiliensi adalah dua konsep psikologis yang penting dalam memahami pengalaman pasien penderita kanker. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh regulasi emosi terhadap resiliensi pada pasien kanker, dengan mempertimbangkan faktor gender dan tahap perkembangan. Penelitian ini melibatkan 30 pasien penderita kanker sebagai sampel penelitian dengan teknik pengambilan sampel total sampling. Instrumen yang digunakan dalam penelitian ini adalah skala regulasi emosi dan resiliensi. Teknik analisis yang digunakan dalam penelitian ini adalah uji deskriptif dan uji regresi linier sederhana. Temuan peda penelitian ini menunjukkan terdapat hubungan positif antara regulasi emosi dan resiliensi pada pasien penderita kanker. Pasien dengan kemampuan regulasi emosi yang baik cenderung memiliki tingkat resiliensi yang lebih tinggi, yang berarti mereka lebih mampu menghadapi tantangan dan tekanan yang terkait dengan penyakit kanker. Temuan lain yang menarik disini adalah lansia yang menderita kanker, mereka menunjukkan tingkat resiliensi yang tinggi, tetapi kemampuan mereka dalam mengontrol emosi cenderung terbatas.

Objective: The characterization framework proposed in this work presents the strategic decisions and their characteristics and the strategic characterization structure of the supply chain. Methodology: This article presents a framework for the strategic characterization of supply chains. The structure is supported by a group of studies that have identified and established the relationships between the decisions of the supply chain. Results: The framework defines the various aspects of the chain that are described from the decision-making paradigm in a strategic environment. In this way, a decision-making selection process can be developed and a structure can be created to analyze the effectiveness of its management. Conclusions: The present work resulted from the discovery of a research gap related to the lack of adequate support methodologies for making strategic decisions, providing a holistic view of the chain’s competitors. An attractive future research perspective could also encompass tactical decisions alongside current strategic ones.

The aim of this research is to understand how adolescents' social skills relate to their understanding of the meaning of life. This research uses a qualitative descriptive type of research which aims to analyze the social skills and meaning of life of Madrasah Aliyah X students in Medan City. The research method used was descriptive qualitative by collecting data through interviews with 5 students at Madrasah Aliyah X in Medan City. The research results show that there is a relationship between social skills and understanding the meaning of life in adolescents. The results can provide insight to educators and parents about the importance of developing social skills in helping teenagers live their teenage years better. In addition, this research also provides further understanding of how adolescents respond to social challenges and how this can influence their understanding of life goals. Therefore, the recommendation from this research is the need for a holistic approach in adolescent education which includes the development of social skills and understanding the meaning of life. Apart from that, there needs to be support and guidance from parents and educators in helping teenagers live their teenage years better.

Abstract Background Although WD repeat and high-mobility group box DNA binding protein 1 (WDHD1) played an essential role in DNA replication, chromosome stability, and DNA damage repair, the panoramic picture of WDHD1 in human tumors remains unclear. Hence, this study aims to comprehensively characterize WDHD1 across 33 human cancers. Methods Based on publicly available databases such as TCGA, GTEx, and HPA, we used a bioinformatics approach to systematically explore the genomic features and biological functions of WDHD1 in pan-cancer. Results WDHD1 mRNA levels were significantly increased in more than 20 types of tumor tissues. Elevated WDHD1 expression was associated with significantly shorter overall survival (OS) in 10 tumors. Furthermore, in uterine corpus endometrial carcinoma (UCEC) and liver hepatocellular carcinoma (LIHC), WDHD1 expression was significantly associated with higher histological grades and pathological stages. In addition, WDHD1 had a high diagnostic value among 16 tumors (area under the ROC curve [AUC] > 0.9). Functional enrichment analyses suggested that WDHD1 probably participated in many oncogenic pathways such as E2F and MYC targets (false discovery rate [FDR]

Abstract Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) through epigenetic manipulation. While the essential role of miRNA in reprogramming and maintaining pluripotency is well studied, little is known about the functions of miRNA from exosomes in this context. To fill this research gap,we comprehensively obtained the 17 sets of cellular mRNA transcriptomic data with 3.93 × 1010 bp raw reads and 18 sets of exosomal miRNA transcriptomic data with 2.83 × 107 bp raw reads from three categories of human somatic cells: peripheral blood mononuclear cells (PBMCs), skin fibroblasts(SFs) and urine cells (UCs), along with their derived iPSCs. Additionally, differentially expressed molecules of each category were identified and used to perform gene set enrichment analysis. Our study provides sets of comparative transcriptomic data of cellular mRNA and exosomal miRNA from three categories of human tissue with three individual biological controls in studies of iPSCs generation, which will contribute to a better understanding of donor cell variation in functional epigenetic regulation and differentiation bias in iPSCs.

Abstract Background To compare the survival rates of four timing of treatment initiation for people living with HIV/AIDS provided in China in 2006, 2011, 2015, and 2018, and to investigate the factors impacting survival time. Methods A people living with HIV/AIDS retrospective cohort study was in Liuzhou City from April 2006 to December 2020. The information was obtained from the National Comprehensive AIDS Prevention and Control Information System. Life tables and the Kaplan–Meier method were used to calculate participant survival rates and time. The univariate and multivariate Cox regression models were used to investigate the factors related to survival. Results 18,543 participants were included in this study. In four periods, the 1-year survival rates were 81%, 87%, 95%, and 95%. The 2-year survival rates were 76%, 85%, 93%, and 94%. The 3-year survival rates were 73%, 84%, 92%, and 94%. Results of multivariate Cox regression showed that sex, age of HIV diagnosis, ethnicity, household registration, occupation, marital status, the timing of treatment, education level, route of HIV transmission, whether receiving antiretroviral therapy (ART), and the count of CD4+T cells at baseline (count of CD4+T cells at HIV diagnosis) were factors that are significantly correlated with mortality caused by HIV infection. Conclusions With the Guidelines updated from 2006 to 2020, the 1-, 2-, and 3-year survival rates of people living with HIV/AIDS in four periods tended to increase. The timing of treatment initiation of the updated edition of the AIDS Diagnostic and Treatment Guidelines (Guidelines) significantly prolonged the survival time of people living with HIV/AIDS.