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103. Predictors of enhancing human physical attractiveness: Data from 93 countries

Author

Kowal, Marta, Sorokowski, Piotr, Pisanski, Katarzyna, Valentova, Jaroslava V., Varella, Marco A.C., Frederick, David A., Al-Shawaf, Laith, García, Felipe E., Giammusso, Isabella, Gjoneska, Biljana, Kozma, Luca, Otterbring, Tobias, Papadatou-Pastou, Marietta, Pfuhl, Gerit, Stöckli, Sabrina, Studzinska, Anna, Toplu-Demirtaş, Ezgi, Touloumakos, Anna K., Bakos, Bence E., Batres, Carlota, Bonneterre, Solenne, Czamanski-Cohen, Johanna, Dacanay, Jovi C., Deschrijver, Eliane, Fisher, Maryanne L., Grano, Caterina, Grigoryev, Dmitry, Kačmár, Pavol, Kozlov, Mikhail V., Manunta, Efisio, Massar, Karlijn, McFall, Joseph P., Mebarak, Moises, Miccoli, Maria Rosa, Milfont, Taciano L., Prokop, Pavol, Aavik, Toivo, Arriaga, Patrícia, Baiocco, Roberto, Čeněk, Jiří, Çetinkaya, Hakan, Duyar, Izzet, Guemaz, Farida, Ishii, Tatsunori, Kamburidis, Julia A., Khun-Inkeeree, Hareesol, Lidborg, Linda H., Manor, Hagar, Nussinson, Ravit, Omar-Fauzee, Mohd Sofian B., Pazhoohi, Farid, Ponnet, Koen, Santos, Anabela Caetano, Senyk, Oksana, Spasovski, Ognen, Vintila, Mona, Wang, Austin H., Yoo, Gyesook, Zerhouni, Oulmann, Amin, Rizwana, Aquino, Sibele, Boğa, Merve, Boussena, Mahmoud, Can, Ali R., Can, Seda, Castro, Rita, Chirumbolo, Antonio, Çoker, Ogeday, Cornec, Clément, Dural, Seda, Eder, Stephanie J., Moharrampour, Nasim Ghahraman, Grassini, Simone, Hristova, Evgeniya, Ikizer, Gözde, Kervyn, Nicolas, Koyuncu, Mehmet, Kunisato, Yoshihiko, Lins, Samuel, Mandzyk, Tetyana, Mari, Silvia, Mattiassi, Alan D.A., Memisoglu-Sanli, Aybegum, Morelli, Mara, Novaes, Felipe C., Parise, Miriam, Banai, Irena Pavela, Perun, Mariia, Plohl, Nejc, Sahli, Fatima Zahra, Šakan, Dušana, Smojver-Azic, Sanja, Solak, Çağlar, Söylemez, Sinem, Toyama, Asako, Wlodarczyk, Anna, Yamada, Yuki, Abad-Villaverde, Beatriz, Afhami, Reza, Akello, Grace, Alami, Nael H., Alma, Leyla, Argyrides, Marios, Atamtürk, Derya, Burduli, Nana, Cardona, Sayra, Carneiro, João, Castañeda, Andrea, Chałatkiewicz, Izabela, Chopik, William J., Chubinidze, Dimitri, Conroy-Beam, Daniel, Contreras-Garduño, Jorge, da Silva, Diana Ribeiro, Don, Yahya B., Donato, Silvia, Dubrov, Dmitrii, Duračková, Michaela, Dutt, Sanjana, Ebimgbo, Samuel O., Estevan, Ignacio, Etchezahar, Edgardo, Fedor, Peter, Fekih-Romdhane, Feten, Frackowiak, Tomasz, Galasinska, Katarzyna, Gargula, Łukasz, Gelbart, Benjamin, Yepes, Talia Gomez, Hamdaoui, Brahim, Hromatko, Ivana, Itibi, Salome N., Jaforte, Luna, Janssen, Steve M.J., Jovic, Marija, Kertechian, Kevin S., Khan, Farah, Kobylarek, Aleksander, Koso-Drljevic, Maida, Krasnodębska, Anna, Križanić, Valerija, Landa-Blanco, Miguel, Mailhos, Alvaro, Marot, Tiago, Dorcic, Tamara Martinac, Martinez-Banfi, Martha, Yusof, Mat Rahimi, Mayorga-Lascano, Marlon, Mikuličiūtė, Vita, Mišetić, Katarina, Musil, Bojan, Najmussaqib, Arooj, Muthu, Kavitha Nalla, Natividade, Jean C., Ndukaihe, Izuchukwu L.G., Nyhus, Ellen K., Oberzaucher, Elisabeth, Omar, Salma S., Ostaszewski, Franciszek, Pacquing, Ma. Criselda T., Pagani, Ariela F., Park, Ju Hee, Pirtskhalava, Ekaterine, Reips, Ulf-Dietrich, Reyes, Marc Eric S., Röer, Jan P., Şahin, Ayşegül, Samekin, Adil, Sargautytė, Rūta, Semenovskikh, Tatiana, Siepelmeyer, Henrik, Singh, Sangeeta, Sołtys, Alicja, Sorokowska, Agnieszka, Soto-López, Rodrigo, Sultanova, Liliya, Tamayo-Agudelo, William, Tan, Chee-Seng, Topanova, Gulmira T., Bulut, Merve Topcu, Trémolière, Bastien, Tulyakul, Singha, Türkan, Belgüzar N., Urbanek, Arkadiusz, Volkodav, Tatiana, Walter, Kathryn V., Yaakob, Mohd Faiz Mohd, and Zumárraga-Espinosa, Marcos

Published
2022
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104. Commissioning and preliminary performance of the MEG II drift chamber

Author

Chiappini, M., Chiarello, G., Baldini, A.M., Benmansour, H., Cavoto, G., Cei, F., Corvaglia, A., Cuna, F., Dal Maso, G., Francesconi, M., Galli, L., Grancagnolo, F., Grassi, M., Hildebrandt, M., Ignatov, F., Meucci, M., Miccoli, A., Molzon, W., Nicolò, D., Oya, A., Palo, D., Panareo, M., Papa, A., Raffaelli, F., Renga, F., Schwendimann, P., Signorelli, G., Tassielli, G.F., Uchiyama, Y., Venturini, A., Vitali, B., and Voena, C.

Published
2022
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105. Factors Affecting Patency of In Situ Saphenous Vein Bypass: Two Year Results from LIMBSAVE (Treatment of critical Limb Ischaemia with infragenicular Bypass adopting in situ SAphenous VEin technique) Registry

Author

Accrocca, Federico, Amico, Alessio, Angelini, Andrea, Arnuzzo, Luca, Marchetti, Andrea Ascoli, Attisani, Luca, Bafile, Gennaro, Baldino, Giuseppe, Barbanti, Enrico, Bartoli, Stefano, Bellosta, Raffaello, Benedetto, Filippo, Borioni, Raoul, Briolini, Franco, Busoni, Cristina, Camparini, Stefano, Cappiello, Pierluigi, Carbonari, Luciano, Casella, Francesco, Celoria, Giovanni, Chiama, Andrea, Chisci, Emiliano, Civilini, Efrem, Codispoti, Francesco, Conti, Barbara, Coppi, Giovanni, De Blasis, Giovanni, D’Elia, Marcello, Di Domenico, Rossella, Di Girolamo, Carla, Ercolini, Leonardo, Ferrari, Alessandra, Ferrari, Mauro, Forliti, Enzo, Frigatti, Paolo, Frigerio, Dalmazio, Frosini, Pierfrancesco, Garriboli, Luca, Giordano, Antonio Nicola, Guerrieri, Walter, Jannello, Antonio, Massara, Mafalda, Merlo, Maurizio, Mezzetti, Roberto, Miccoli, Tommaso, Milite, Domenico, Mingazzini, Pietro, Muncinelli, Marina, Nano, Giovanni, Natola, Marco, Novali, Claudio, Palasciano, Giancarlo, Perkmann, Reinhold, Persi, Federica, Petruccelli, David, Pinelli, Mauro, Poletto, Giorgio, Porta, Carla, Pratesi, Carlo, Pruner, Gianguido, Ragazzi, Giovanni, Righini, Paolo, Salvini, Mauro, Scovazzi, Paolo, Setacci, Carlo, Settembrini, Alberto Maria, Siani, Andrea, Silingardi, Roberto, Silvestro, Antonino, Talarico, Francesco, Tolva, Valerio, Trani, Antonio, Trimarchi, Santi, Tshomba, Yamume, Vigliotti, Gennaro, Viola, Daniela, Volpe, Pietro, Zani, Federico, Troisi, Nicola, Adami, Daniele, Michelagnoli, Stefano, and Berchiolli, Raffaella

Published
2022
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106. Construction and test of the SM1 type Micromegas chambers for the upgrade of the ATLAS forward muon spectrometer

Author

Agarwala, J., Alviggi, M.G., Antonelli, M., Anulli, F., Arcangeletti, C., Auricchio, S., Bagnaia, P., Bariani, S., Baroncelli, A., Bashta, I., Bauce, M., Beretta, M., Bini, C., Calabró, D., Camerlingo, M.T., Canale, V., Capitolo, E., Capponi, M., Capradossi, G., Carducci, G., Caserio, A., Cassese, C., Cerioni, S., Chiarella, V., Ciapetti, G., D’Amico, V., De Cecco, S., De Fazio, B., Del Gaudio, M., Di Donato, C., Di Nardo, R., D’Uffizi, D., Farilla, A., Farina, E., Ferrari, R., Fiore, G., Frattari, G., Freddi, A., Gaudio, G., Gauzzi, P., Giagu, S., Gigli, S., Gnesi, I., Gorini, E., Gravili, F.G., Greco, M., Iaciofano, A., Iengo, P., Innocente, A., Introzzi, G., Iodice, M., Ippolito, V., Kourkoumeli Charalampidi, A., Lacava, F., Lalli, E., Lanza, A., Lauciani, S., Laurelli, P., Luminari, L., Mancini, G., Martinelli, L., Massarotti, P., Miccoli, A., Mirto, A., Negri, A., Orestano, D., Paruzza, G., Pepe, M., Petruccetti, M., Petrucci, F., Pezzotti, L., Pileggi, G., Pirola, M., Piscitelli, C., Polesello, G., Policicchio, A., Pontoriere, G., Ponzio, B., Primavera, M., Rebuzzi, D., Rimoldi, A., Romano, E., Roscilli, L., Rovelli, G., Russo, V., Sansoni, A., Safai Tehrani, F., Scagliotti, C., Schioppa, M., Sekhniaidze, G., Sessa, M., Sottocornola, S., Trattino, P., Tskhadadze, E., Turco, P., Vannicola, D., Vannoli, L., Vassilieva, T., Vecchio, V., Ventura, A., Vercellati, F., Vilucchi, E., Zullo, A., and Zunica, G.

Published
2022
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109. Development of novel phospho-amino acid prodrugs as powerful tools in drug discovery

Author

Miccoli, Ageo

Subjects
615.1, Q Science (General)
Abstract

Acting as protein-protein inhibitors, phosphotyrosine/serine-mimetics have demonstrated potent and diverse therapeutic activities, particularly against cancer. In particular, phosphotyrosine- derived molecules, peptic or peptidomimetic, could be applied to re-establishing control of the hyperactivated STAT/JAK pathway in several cancers. Overexpression of tumour-promoting genes has been associated with abnormal accumulations of signal transducer and activator of transcription (STAT) proteins being phosphorylated at their SH2 domain, by specific Janus Kinases (JAKs), at specific phosphotyrosine residues. Abundancies of phosphorylated STAT proteins can dimerise, allowing translocation to the nucleus where overexpression of survival genes occurs, aiding tumourigenesis. Small, synthetic molecules that mimic the STAT3 phosphotyrosine residue and inhibit STAT3 homodimerisation have been shown to prohibit dimerisation and gene overexpression. Despite their therapeutic promise, phosphotyrosine-mimetic drugs have not progressed to the clinics owing to their biocleavable and charged phosphate moieties. The repulsive charge of the phosphate group makes this class of compounds impermeable to cell membranes. This shortfall is paralleled in phosphoserine-mimetic drug molecules, which also contain charged phosphate functionalities. In this work, we explored how encaging these phosphate groups in a novel prodrug form would overcome their permeability issue, which could translate into improved pharmacological activity. To this end, the research hypothesis was evaluated on a known phosphotyrosine-mimetic STAT3 inhibitor, ISS-610, as a proof-of-concept. A small library of novel ISS-610-Me phosphoramidate prodrugs was synthesised and evaluated for their anti-STAT3 activity and stability. The positive results from this small series validated the proposal and the prodrug technology was thus progressed to a novel STAT3 inhibitor, derived from the anti-STAT3 pharmacophore, S31-201. A larger library of novel phosphoramidate and known phosphate prodrugs was synthesised for this series, alongside a novel phosphate prodrug delivery system, which also displayed improved potency and good stability. The prodrug application was then applied to phosphopeptide-mimetic molecules, specifically to two anticancer molecules, which inhibit STAT5b or 14-3-3 dimerisation. Upon synthesis of these compounds and their prodrugs, the biological activity of the prodrugs was found to be superior to the parent compounds. In conclusion, this work collectively highlights the potential and applicability of phosphoramidate prodrug technology for improving the delivery and, thus, the pharmacological activity of phosphopeptide-mimetic (anticancer) therapeutics.

Published
2019

110. Doping liquid argon with xenon in ProtoDUNE Single-Phase: effects on scintillation light

Author

Abed Abud, A, Abi, B, Acciarri, R, Acero, M, Adames, M, Adamov, G, Adamowski, M, Adams, D, Adinolfi, M, Adriano, C, Aduszkiewicz, A, Aguilar, J, Aimard, B, Akbar, F, Allison, K, Alonso Monsalve, S, Alrashed, M, Alton, A, Alvarez, R, Amar Es-sghir, H, Amedo, P, Anderson, J, Andrade, D, Andreopoulos, C, Andreotti, M, Andrews, M, Andrianala, F, Andringa, S, Anfimov, N, Ankowski, A, Antoniassi, M, Antonova, M, Antoshkin, A, Aranda-Fernandez, A, Arellano, L, Arrieta Diaz, E, Arroyave, M, Asaadi, J, Ashkenazi, A, Asquith, L, Atkin, E, Auguste, D, Aurisano, A, Aushev, V, Autiero, D, Azfar, F, Back, A, Back, H, Back, J, Bagaturia, I, Bagby, L, Balashov, N, Balasubramanian, S, Baldi, P, Baldini, W, Baller, B, Bambah, B, Banerjee, R, Barao, F, Barenboim, G, Barham Alzás, P, Barker, G, Barkhouse, W, Barr, G, Barranco Monarca, J, Barros, A, Barros, N, Barrow, D, Barrow, J, Basharina-Freshville, A, Bashyal, A, Basque, V, Batchelor, C, Bathe-Peters, L, Battat, J, Battisti, F, Bay, F, Bazetto, M, Bazo Alba, J, Beacom, J, Bechetoille, E, Behera, B, Belchior, E, Bell, G, Bellantoni, L, Bellettini, G, Bellini, V, Beltramello, O, Benekos, N, Benitez Montiel, C, Benjamin, D, Bento Neves, F, Berger, J, Berkman, S, Bernardini, P, Bersani, A, Bertolucci, S, Betancourt, M, Betancur Rodríguez, A, Bevan, A, Bezawada, Y, Bezerra, A, Bezerra, T, Bhat, A, Bhatnagar, V, Bhatt, J, Bhattacharjee, M, Bhattacharya, M, Bhuller, S, Bhuyan, B, Biagi, S, Bian, J, Biery, K, Bilki, B, Bishai, M, Bitadze, A, Blake, A, Blaszczyk, F, Blazey, G, Blucher, E, Boissevain, J, Bolognesi, S, Bolton, T, Bomben, L, Bonesini, M, Bonilla-Diaz, C, Bonini, F, Booth, A, Boran, F, Bordoni, S, Borges Merlo, R, Borkum, A, Bostan, N, Bracinik, J, Braga, D, Brahma, B, Brailsford, D, Bramati, F, Branca, A, Brandt, A, Bremer, J, Brew, C, Brice, S, Brio, V, Brizzolari, C, Bromberg, C, Brooke, J, Bross, A, Brunetti, G, Brunetti, M, Buchanan, N, Budd, H, Buergi, J, Burgardt, D, Butchart, S, Caceres Vera, G, Cagnoli, I, Cai, T, Calabrese, R, Calcutt, J, Calin, M, Calivers, L, Calvo, E, Caminata, A, Campanelli, W, Campos Benitez, A, Canci, N, Capó, J, Caracas, I, Caratelli, D, Carber, D, Carceller, J, Carini, G, Carlus, B, Carneiro, M, Carniti, P, Caro Terrazas, I, Carranza, H, Carrara, N, Carroll, L, Carroll, T, Carter, A, Casazza, D, Castaño Forero, J, Castaño, F, Castillo, A, Castromonte, C, Catano-Mur, E, Cattadori, C, Cavalier, F, Cavanna, F, Centro, S, Cerati, G, Cervelli, A, Cervera Villanueva, A, Chakraborty, K, Chalifour, M, Chappell, A, Charitonidis, N, Chatterjee, A, Chen, H, Chen, M, Chen, W, Chen, Y, Chen-Wishart, Z, Cherdack, D, Chi, C, Chirco, R, Chitirasreemadam, N, Cho, K, Choate, S, Chokheli, D, Chong, P, Chowdhury, B, Christian, D, Chukanov, A, Chung, M, Church, E, Cicala, M, Cicerchia, M, Cicero, V, Ciolini, R, Clair, J, Clarke, P, Cline, G, Coan, T, Cocco, A, Coelho, J, Cohen, A, Collot, J, Conley, E, Conrad, J, Convery, M, Cooke, P, Copello, S, Cova, P, Cox, C, Cremaldi, L, Cremonesi, L, Crespo-Anadón, J, Crisler, M, Cristaldo, E, Crnkovic, J, Crone, G, Cross, R, Cudd, A, Cuesta, C, Cui, Y, Cussans, D, Dai, J, Dalager, O, Dallavalle, R, da Motta, H, Dar, Z, Darby, R, Da Silva Peres, L, David, Q, Davies, G, Davini, S, Dawson, J, De Aguiar, R, De Almeida, P, Debbins, P, De Bonis, I, Decowski, M, de Gouvêa, A, De Holanda, P, De Icaza Astiz, I, De Jong, P, De la Torre, A, Delbart, A, Delepine, D, Delgado, M, Dell'Acqua, A, Delle Monache, G, Delmonte, N, De Lurgio, P, Demario, R, de Mello Neto, J, Demuth, D, Dennis, S, Densham, C, Denton, P, Deptuch, G, De Roeck, A, De Romeri, V, Detje, J, Devine, J, Dharmapalan, R, Dias, M, Díaz, J, Díaz, F, Di Capua, F, Di Domenico, A, Di Domizio, S, Di Falco, S, Di Giulio, L, Ding, P, Di Noto, L, Diociaiuti, E, Distefano, C, Diurba, R, Diwan, M, Djurcic, Z, Doering, D, Dolan, S, Dolek, F, Dolinski, M, Domenici, D, Domine, L, Donati, S, Donon, Y, Doran, S, Douglas, D, Doyle, T, Dragone, A, Drielsma, F, Duarte, L, Duchesneau, D, Duffy, K, Dugas, K, Dunne, P, Dutta, B, Duyang, H, Dvornikov, O, Dwyer, D, Dyshkant, A, Dytman, S, Eads, M, Earle, A, Edayath, S, Edmunds, D, Eisch, J, Englezos, P, Ereditato, A, Erjavec, T, Escobar, C, Evans, J, Ewart, E, Ezeribe, A, Fahey, K, Fajt, L, Falcone, A, Fani', M, Farnese, C, Farzan, Y, Fedoseev, D, Felix, J, Feng, Y, Fernandez-Martinez, E, Ferraro, F, Ferry, G, Fields, L, Filip, P, Filkins, A, Filthaut, F, Fine, R, Fiorillo, G, Fiorini, M, Fogarty, S, Foreman, W, Fowler, J, Franc, J, Francis, K, Franco, D, Franklin, J, Freeman, J, Fried, J, Friedland, A, Fuess, S, Furic, I, Furman, K, Furmanski, A, Gaba, R, Gabrielli, A, Gago, A, Galizzi, F, Gallagher, H, Gallas, A, Gallice, N, Galymov, V, Gamberini, E, Gamble, T, Ganacim, F, Gandhi, R, Ganguly, S, Gao, F, Gao, S, Garcia-Gamez, D, García-Peris, M, Gardiner, S, Gastler, D, Gauch, A, Gauvreau, J, Gauzzi, P, Ge, G, Geffroy, N, Gelli, B, Gent, S, Gerlach, L, Ghorbani-Moghaddam, Z, Giammaria, P, Giammaria, T, Gibin, D, Gil-Botella, I, Gilligan, S, Gioiosa, A, Giovannella, S, Girerd, C, Giri, A, Giugliano, C, Giusti, V, Gnani, D, Gogota, O, Gollapinni, S, Gollwitzer, K, Gomes, R, Gomez Bermeo, L, Gomez Fajardo, L, Gonnella, F, Gonzalez-Diaz, D, Gonzalez-Lopez, M, Goodman, M, Goswami, S, Gotti, C, Goudeau, J, Goudzovski, E, Grace, C, Gramellini, E, Gran, R, Granados, E, Granger, P, Grant, C, Gratieri, D, Grauso, G, Green, P, Greenberg, S, Greer, J, Griffith, W, Groetschla, F, Grzelak, K, Gu, W, Guarino, V, Guarise, M, Guenette, R, Guerard, E, Guerzoni, M, Guffanti, D, Guglielmi, A, Guo, B, Guo, Y, Gupta, A, Gupta, V, Gurung, G, Gutierrez, D, Guzowski, P, Guzzo, M, Gwon, S, Haaf, K, Habig, A, Hadavand, H, Haenni, R, Hagaman, L, Hahn, A, Haiston, J, Hakenmueller, J, Hamernik, T, Hamilton, P, Hancock, J, Happacher, F, Harris, D, Hartnell, J, Hartnett, T, Harton, J, Hasegawa, T, Hasnip, C, Hatcher, R, Hayrapetyan, K, Hays, J, Hazen, E, He, M, Heavey, A, Heeger, K, Heise, J, Henry, S, Hernandez Morquecho, M, Herner, K, Hewes, V, Higuera, A, Hilgenberg, C, Hillier, S, Himmel, A, Hinkle, E, Hirsch, L, Ho, J, Hoff, J, Holin, A, Holvey, T, Hoppe, E, Horton-Smith, G, Hostert, M, Houdy, T, Howard, B, Howell, R, Hristova, I, Hronek, M, Huang, J, Huang, R, Hulcher, Z, Ibrahim, M, Iles, G, Ilic, N, Iliescu, A, Illingworth, R, Ingratta, G, Ioannisian, A, Irwin, B, Isenhower, L, Ismerio Oliveira, M, Itay, R, Jackson, C, Jain, V, James, E, Jang, W, Jargowsky, B, Jena, D, Ji, X, Jiang, C, Jiang, J, Jiang, L, Jipa, A, Joaquim, F, Johnson, W, Jones, B, Jones, R, José Fernández, D, Jovancevic, N, Judah, M, Jung, C, Junk, T, Jwa, Y, Kabirnezhad, M, Kaboth, A, Kadenko, I, Kakorin, I, Kalitkina, A, Kalra, D, Kamiya, F, Kandemir, M, Kaplan, D, Karagiorgi, G, Karaman, G, Karcher, A, Karyotakis, Y, Kasai, S, Kasetti, S, Kashur, L, Katsioulas, I, Kauther, A, Kazaryan, N, Ke, L, Kearns, E, Keener, P, Kelly, K, Kemp, E, Kemularia, O, Kermaidic, Y, Ketchum, W, Kettell, S, Khabibullin, M, Khan, N, Khvedelidze, A, Kim, D, Kim, J, King, B, Kirby, B, Kirby, M, Klein, J, Kleykamp, J, Klustova, A, Kobilarcik, T, Koch, L, Koehler, K, Koerner, L, Koh, D, Kolupaeva, L, Korablev, D, Kordosky, M, Kosc, T, Kose, U, Kostelecký, V, Kothekar, K, Kotler, I, Kovalcuk, M, Kozhukalov, V, Krah, W, Kralik, R, Kramer, M, Kreczko, L, Krennrich, F, Kreslo, I, Kroupova, T, Kubota, S, Kubu, M, Kudenko, Y, Kudryavtsev, V, Kuhlmann, S, Kumar, J, Kumar, P, Kumaran, S, Kunze, P, Kunzmann, J, Kuravi, R, Kurita, N, Kuruppu, C, Kus, V, Kutter, T, Kvasnicka, J, Labree, T, Lackey, T, Lambert, A, Land, B, Lane, C, Lane, N, Lang, K, Langford, T, Langstaff, M, Lanni, F, Lantwin, O, Larkin, J, Lasorak, P, Last, D, Laudrain, A, Laundrie, A, Laurenti, G, Lavaut, E, Lawrence, A, Laycock, P, Lazanu, I, Lazzaroni, M, Le, T, Leardini, S, Learned, J, Lecompte, T, Lee, C, Legin, V, Lehmann Miotto, G, Lehnert, R, Leigui de Oliveira, M, Leitner, M, Leon Silverio, D, Lepin, L, Li, J, Li, S, Li, Y, Liao, H, Lin, C, Lindebaum, D, Lineros, R, Ling, J, Lister, A, Littlejohn, B, Liu, H, Liu, J, Liu, Y, Lockwitz, S, Lokajicek, M, Lomidze, I, Long, K, Lopes, T, Lopez, J, López de Rego, I, López March, N, Lord, T, Losecco, J, Louis, W, Lozano Sanchez, A, Lu, X, Luk, K, Lunday, B, Luo, X, Luppi, E, Maalmi, J, Macfarlane, D, Machado, A, Machado, P, Macias, C, Macier, J, Macmahon, M, Maddalena, A, Madera, A, Madigan, P, Magill, S, Magueur, C, Mahn, K, Maio, A, Major, A, Majumdar, K, Man, M, Mandujano, R, Maneira, J, Manly, S, Mann, A, Manolopoulos, K, Manrique Plata, M, Manthey Corchado, S, Manyam, V, Marchan, M, Marchionni, A, Marciano, W, Marfatia, D, Mariani, C, Maricic, J, Marinho, F, Marino, A, Markiewicz, T, Das Chagas Marques, F, Marsden, D, Marshak, M, Marshall, C, Marshall, J, Martín-Albo, J, Martinez, N, Martinez Caicedo, D, Martínez López, F, Martínez Miravé, P, Martynenko, S, Mascagna, V, Massari, C, Mastbaum, A, Matichard, F, Matsuno, S, Matteucci, G, Matthews, J, Mauger, C, Mauri, N, Mavrokoridis, K, Mawby, I, Mazza, R, 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Abstract

Doping of liquid argon TPCs (LArTPCs) with a small concentration of xenon is a technique for light-shifting and facilitates the detection of the liquid argon scintillation light. In this paper, we present the results of the first doping test ever performed in a kiloton-scale LArTPC. From February to May 2020, we carried out this special run in the single-phase DUNE Far Detector prototype (ProtoDUNE-SP) at CERN, featuring 720 t of total liquid argon mass with 410 t of fiducial mass. A 5.4 ppm nitrogen contamination was present during the xenon doping campaign. The goal of the run was to measure the light and charge response of the detector to the addition of xenon, up to a concentration of 18.8 ppm. The main purpose was to test the possibility for reduction of nonuniformities in light collection, caused by deployment of photon detectors only within the anode planes. Light collection was analysed as a function of the xenon concentration, by using the pre-existing photon detection system (PDS) of ProtoDUNE-SP and an additional smaller set-up installed specifically for this run. In this paper we first summarize our current understanding of the argon-xenon energy transfer process and the impact of the presence of nitrogen in argon with and without xenon dopant. We then describe the key elements of ProtoDUNE-SP and the injection method deployed. Two dedicated photon detectors were able to collect the light produced by xenon and the total light. The ratio of these components was measured to be about 0.65 as 18.8 ppm of xenon were injected. We performed studies of the collection efficiency as a function of the distance between tracks and light detectors, demonstrating enhanced uniformity of response for the anode-mounted PDS. We also show that xenon doping can substantially recover light losses due to contamination of the liquid argon by nitrogen.

Published
2024

111. The DUNE Far Detector Vertical Drift Technology. Technical Design Report

Author

Abed Abud, A, Abi, B, Acciarri, R, Acero, M, Adames, M, Adamov, G, Adamowski, M, Adams, D, Adinolfi, M, Adriano, C, Aduszkiewicz, A, Aguilar, J, Aimard, B, Akbar, F, Allison, K, Alonso Monsalve, S, Alrashed, M, Alton, A, Alvarez, R, Alves, T, Amar, H, Amedo, P, Anderson, J, Andrade, D, Andreopoulos, C, Andreotti, M, Andrews, M, Andrianala, F, Andringa, S, Anfimov, N, Ankowski, A, Antoniassi, M, Antonova, M, Antoshkin, A, Aranda-Fernandez, A, Arellano, L, Arrieta Diaz, E, Arroyave, M, Asaadi, J, Ashkenazi, A, Asner, D, Asquith, L, Atkin, E, Auguste, D, Aurisano, A, Aushev, V, Autiero, D, Azfar, F, Back, A, Back, H, Back, J, Bagaturia, I, Bagby, L, Balashov, N, Balasubramanian, S, Baldi, P, Baldini, W, Baldonedo, J, Baller, B, Bambah, B, Banerjee, R, Barao, F, Barenboim, G, Barham Alzás, P, Barker, G, Barkhouse, W, Barr, G, Barranco Monarca, J, Barros, A, Barros, N, Barrow, D, Barrow, J, Basharina-Freshville, A, Bashyal, A, Basque, V, Batchelor, C, Bathe-Peters, L, Battat, J, Battisti, F, Bay, F, Bazetto, M, Bazo Alba, J, Beacom, J, Bechetoille, E, Behera, B, Belchior, E, Bell, G, Bellantoni, L, Bellettini, G, Bellini, V, Beltramello, O, Benekos, N, Benitez Montiel, C, Benjamin, D, Bento Neves, F, Berger, J, Berkman, S, Bernal, J, Bernardini, P, Bersani, A, Bertolucci, S, Betancourt, M, Betancur Rodríguez, A, Bevan, A, Bezawada, Y, Bezerra, A, Bezerra, T, Bhat, A, Bhatnagar, V, Bhatt, J, Bhattacharjee, M, Bhattacharya, M, Bhuller, S, Bhuyan, B, Biagi, S, Bian, J, Biery, K, Bilki, B, Bishai, M, Bitadze, A, Blake, A, Blaszczyk, F, Blazey, G, Blucher, E, Bogenschuetz, J, Boissevain, J, Bolognesi, S, Bolton, T, Bomben, L, Bonesini, M, Bonilla-Diaz, C, Bonini, F, Booth, A, Boran, F, Bordoni, S, Borges Merlo, R, Borkum, A, Bostan, N, Bouet, R, Bracinik, J, Brahma, B, Brailsford, D, Bramati, F, Branca, A, Brandt, A, Bremer, J, Brew, C, Brice, S, Brio, V, Brizzolari, C, Bromberg, C, Brooke, J, Bross, A, Brunetti, G, Brunetti, M, Buchanan, N, Budd, H, Buergi, J, Burgardt, D, 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Abstract

DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals.

Published
2024

112. First measurement of the total inelastic cross section of positively charged kaons on argon at energies between 5.0 and 7.5 GeV

Author

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B., Lunday, B., Luo, X., Luppi, E., MacFarlane, D., Machado, A. A., Machado, P., Macias, C. T., Macier, J. R., MacMahon, M., Maddalena, A., Madera, A., Madigan, P., Magill, S., Magueur, C., Mahn, K., Maio, A., Major, A., Majumdar, K., Mameli, S., Man, M., Mandujano, R. C., Maneira, J., Manly, S., Mann, A., Manolopoulos, K., Plata, M. Manrique, Corchado, S. Manthey, Manyam, V. N., Marchan, M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Markiewicz, T., Marques, F. Das Chagas, Marquet, C., Marshak, M., Marshall, C. M., Marshall, J., Martina, L., Martín-Albo, J., Martinez, N., Caicedo, D. A. Martinez, López, F. Martínez, Miravé, P. Martínez, Martynenko, S., Mascagna, V., Massari, C., Mastbaum, A., Matichard, F., Matsuno, S., Matteucci, G., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mawby, I., Mazza, R., McAskill, T., McConkey, N., McFarland, K. S., McGrew, C., McNab, A., Meazza, L., Meddage, V. C. N., Mefodiev, A., Mehta, B., Mehta, P., Melas, P., Mena, O., Mendez, H., Mendez, P., Méndez, D. P., Menegolli, A., Meng, G., Mercuri, A. C. E. A., Meregaglia, A., Messier, M. D., Metallo, S., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Micallef, J., Miccoli, A., Michna, G., Milincic, R., Miller, F., Miller, G., Miller, W., Mineev, O., Minotti, A., Miralles Verge, L., Miranda, O. G., Mironov, C., Miryala, S., Miscetti, S., Mishra, C. S., Mishra, P., Mishra, S. R., Mislivec, A., Mitchell, M., Mladenov, D., Mocioiu, I., Mogan, A., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Bueno, L. Molina, Montagna, E., Montanari, A., Montanari, C., Montanari, D., Montanino, D., Zetina, L. M. Montaño, Mooney, M., Moor, A. F., Moore, Z., Moreno, D., Moreno-Palacios, O., Morescalchi, L., Moretti, D., Moretti, R., Morris, C., Mossey, C., Moura, C. A., Mouster, G., Mu, W., Mualem, L., Mueller, J., Muether, M., Muheim, F., Muir, A., Mulhearn, M., Munford, D., Munteanu, L. J., Muramatsu, H., Muraz, J., Murphy, M., Murphy, T., Muse, J., Mytilinaki, A., Nachtman, J., Nagai, Y., Nagu, S., Nandakumar, R., Naples, D., Narita, S., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nehm, A., Nelson, J. K., Neogi, O., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Nichol, R., Nicolas-Arnaldos, F., Nikolica, A., Nikolov, J., Niner, E., Nishimura, K., Norman, A., Norrick, A., Novella, P., Nowak, A., Nowak, J. A., Oberling, M., Ochoa-Ricoux, J. P., Oh, S., Oh, S. B., Olivier, A., Olshevskiy, A., Olson, T., Onel, Y., Onishchuk, Y., Oranday, A., Osbiston, M., Vélez, J. A. Osorio, O'Sullivan, L., Ormachea, L. Otiniano, Ott, J., Pagani, L., Palacio, G., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pan, S., Panda, P., Vazquez, W. Panduro, Pantic, E., Paolone, V., Papaleo, R., Papanestis, A., Papoulias, D., Paramesvaran, S., Paris, A., Parke, S., Parozzi, E., Parsa, S., Parsa, Z., Parveen, S., Parvu, M., Pasciuto, D., Pascoli, S., Pasqualini, L., Pasternak, J., Patrick, C., Patrizii, L., Patterson, R. B., Patzak, T., Paudel, A., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Pedreschi, E., Peeters, S. J. M., Pellico, W., Perez, A. Pena, Pennacchio, E., Penzo, A., Peres, O. L. G., Gonzalez, Y. F. Perez, Pérez-Molina, L., Pernas, C., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Pfaff, M., Pia, V., Pickering, L., Pietropaolo, F., Pimentel, V. L., Pinaroli, G., Pincha, S., Pinchault, J., Pitts, K., Plows, K., Pollack, C., Pollman, T., Pompa, F., Pons, X., Poonthottathil, N., Popov, V., Poppi, F., Porter, J., Paixão, L. G. Porto, Potekhin, M., Potenza, R., Pozimski, J., Pozzato, M., Prakash, T., Pratt, C., Prest, M., Psihas, F., Pugnere, D., Qian, X., Queen, J., Raaf, J. L., Radeka, V., Rademacker, J., Radics, B., Raffaelli, F., Rafique, A., Raguzin, E., Rai, M., Rajagopalan, S., Rajaoalisoa, M., Rakhno, I., Rakotondravohitra, L., Ralte, L., Delgado, M. A. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ray, R., Razafinime, H., Rea, E. M., Real, J. S., Rebel, B., Rechenmacher, R., Reichenbacher, J., Reitzner, S. D., Sfar, H. Rejeb, Renner, E., Renshaw, A., Rescia, S., Resnati, F., Restrepo, Diego, Reynolds, C., Ribas, M., Riboldi, S., Riccio, C., Riccobene, G., Ricol, J. S., Rigan, M., Rincón, E. V., Ritchie-Yates, A., Ritter, S., Rivera, D., Rivera, R., Robert, A., Rocha, J. L. Rocabado, Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. Rodriguez, Rondon, J. Rodriguez, Rosauro-Alcaraz, S., Rosier, P., Ross, D., Rossella, M., Rossi, M., Ross-Lonergan, M., Roy, N., Roy, P., Rubbia, C., Ruggeri, A., Ferreira, G. Ruiz, Russell, B., Ruterbories, D., Rybnikov, A., Sacerdoti, S., Saha, S., Sahoo, S. K., Sahu, N., Sala, P., Samios, N., Samoylov, O., Sanchez, M. C., Bravo, A. Sánchez, Sánchez-Castillo, A., Sánchez-Lucas, P., Sandberg, V., Sanders, D. A., Sanfilippo, S., Sankey, D., Santoro, D., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Sarra, I., Savage, G., Savinov, V., Scanavini, G., Scaramelli, A., Scarff, A., Schefke, T., Schellman, H., Schifano, S., Schlabach, P., Schmitz, D., Schneider, A. W., Scholberg, K., Schukraft, A., Schuld, B., Segade, A., Segreto, E., Selyunin, A., Senadheera, D., Senise, C. R., Sensenig, J., Shaevitz, M. H., Shanahan, P., Sharma, P., Kumar, R., Poudel, S. Sharma, Shaw, K., Shaw, T., Shchablo, K., Shen, J., Shepherd-Themistocleous, C., Sheshukov, A., Shi, J., Shi, W., Shin, S., Shivakoti, S., Shoemaker, I., Shooltz, D., Shrock, R., Siddi, B., Siden, M., Silber, J., Simard, L., Sinclair, J., Sinev, G., Singh, Jaydip, Singh, J., Singh, L., Singh, P., Singh, V., Chauhan, S. Singh, Sipos, R., Sironneau, C., Sirri, G., Siyeon, K., Skarpaas, K., Smedley, J., Smith, E., Smith, J., Smith, P., Smolik, J., Smy, M., Snape, M., Snider, E. L., Snopok, P., Snowden-Ifft, D., Nunes, M. Soares, Sobel, H., Soderberg, M., Sokolov, S., Salinas, C. J. Solano, Söldner-Rembold, S., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Sotnikov, A., Soto-Oton, J., Sousa, A., Soustruznik, K., Spinella, F., Spitz, J., Spooner, N. J. C., Spurgeon, K., Stalder, D., Stancari, M., Stanco, L., Steenis, J., Stein, R., Steiner, H. M., Lisbôa, A. F. Steklain, Stepanova, A., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Strigari, L., Stuart, A., Suarez, J. G., Subash, J., Surdo, A., Suter, L., Sutera, C. M., Sutton, K., Suvorov, Y., Svoboda, R., Swain, S. K., Szczerbinska, B., Szelc, A. M., Sztuc, A., Taffara, A., Talukdar, N., Tamara, J., Tanaka, H. A., Tang, S., Taniuchi, N., Casanova, A. M. Tapia, Oregui, B. Tapia, Tapper, A., Tariq, S., Tarpara, E., Tatar, E., Tayloe, R., Tedeschi, D., Teklu, A. M., Vidal, J. Tena, Tennessen, P., Tenti, M., Terao, K., Terranova, F., Testera, G., Thakore, T., Thea, A., Thomas, S., Thompson, A., Thorn, C., Timm, S. C., Tiras, E., Tishchenko, V., Todorović, N., Tomassetti, L., Tonazzo, A., Torbunov, D., Torti, M., Tortola, M., Tortorici, F., Tosi, N., Totani, D., Toups, M., Touramanis, C., Tran, D., Travaglini, R., Trevor, J., Triller, E., Trilov, S., Truchon, J., Truncali, D., Trzaska, W. H., Tsai, Y., Tsai, Y. -T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tu, S. Z., Tufanli, S., Tunnell, C., Turnberg, S., Turner, J., Tuzi, M., Tyler, J., Tyley, E., Tzanov, M., Uchida, M. A., González, J. Ureña, Urheim, J., Usher, T., Utaegbulam, H., Uzunyan, S., Vagins, M. R., Vahle, P., Valder, S., Valdiviesso, G. A., Valencia, E., Valentim, R., Vallari, Z., Vallazza, E., Valle, J. W. F., Van Berg, R., Van de Water, R. G., Forero, D. V., Vannozzi, A., Van Nuland-Troost, M., Varanini, F., Oliva, D. Vargas, Vasina, S., Vaughan, N., Vaziri, K., Vázquez-Ramos, A., Vega, J., Ventura, S., Verdugo, A., Vergani, S., Verzocchi, M., Vetter, K., Vicenzi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Villa, E., Viola, S., Viren, B., Hernandez, A. P. Vizcaya, Vuong, Q., Waldron, A. V., Wallbank, M., Walsh, J., Walton, T., Wang, H., Wang, J., Wang, L., Wang, M. H. L. S., Wang, X., Wang, Y., Warburton, K., Warner, D., Warsame, L., Wascko, M. O., Waters, D., Watson, A., Wawrowska, K., Weber, A., Weber, C. M., Weber, M., Wei, H., Weinstein, A., Westerdale, S., Wetstein, M., Whalen, K., White, A., Whitehead, L. H., Whittington, D., Wilhlemi, J., Wilking, M. J., Wilkinson, A., Wilkinson, C., Wilson, F., Wilson, R. J., Winter, P., Wisniewski, W., Wolcott, J., Wolfs, J., Wongjirad, T., Wood, A., Wood, K., Worcester, E., Worcester, M., Wospakrik, M., Wresilo, K., Wret, C., Wu, S., Wu, W., Wurm, M., Wyenberg, J., Xiao, Y., Xiotidis, I., Yaeggy, B., Yahlali, N., Yandel, E., Yang, J., Yang, K., Yang, T., Yankelevich, A., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, H., Yu, J., Yu, Y., Yuan, W., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zapata, O., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhang, S., Zhao, M., Zhivun, E., Zimmerman, E. D., Zucchelli, S., Zuklin, J., Zutshi, V., Zwaska, R., and null, null

Published
2024

113. Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles.

Author

Cassioli, Chiara, Capitani, Nagaja, Staton, Claire C., Schirra, Claudia, Finetti, Francesca, Onnis, Anna, Alawar, Nadia, Szu-Min Tu, Lopresti, Ludovica, Tatangelo, Vanessa, Tangredi, Carmela, Valvo, Salvatore, Hsin-Fang Chang, Miccoli, Annachiara, Compeer, Ewoud B., Nicholls, Jemma, Blazar, Bruce R., Marotta, Giuseppe, Wood, Matthew J. A., and Trentin, Livio

Subjects
CHRONIC lymphocytic leukemia, STIMULATED emission, ELECTRON microscopy, KILLER cells, T cells
Abstract

Cytotoxic attack particles released by CTLs and NK cells include diverse phospholipid membrane and glycoprotein encapsulated entities that contribute to target cell killing. Supramolecular attack particles (SMAPs) are one type of particle characterized by a cytotoxic core enriched in granzymes and perforin surrounded by a proteinaceous shell including thrombospondin (TSP)-1. TSP-4 was also detected in bulk analysis of SMAPs released by CTLs; however, it has not been investigated whether TSP-4 contributes to distinct SMAP types or the same SMAP type as TSP-1 and, if in the same type of SMAP, whether TSP-4 and TSP-1 cooperate or compete. Here, we observed that TSP-4 expression increased upon CD8+ T cell activation while, surprisingly, TSP-1 was down-regulated. Correlative Light and Electron Microscopy and Stimulated Emission Depletion microscopy localized TSP-4 and TSP-1 in SMAP-containing multicore granules. Superresolution dSTORM revealed that TSP-4 and TSP-1 are usually enriched in the same SMAPs while particles with single-positive shells are rare. Retention Using Selective Hooks assays showed that TSP-4 localizes to the lytic granules faster than TSP-1 and promotes its accumulation therein. TSP-4 contributed to direct CTL-mediated killing, as previously shown for TSP-1. TSP-4 and TSP-1 were both required for latent SMAP-mediated cell killing, in which released SMAPs kill targets after removal of the CTLs. Of note, we found that chronic lymphocytic leukemia (CLL) cell culture supernatants suppressed expression of TSP-4 in CTL and latent SMAP-mediated killing. These results identify TSP-4 as a functionally important component of SMAPs and suggest that SMAPs may be targeted for immune suppression by CLL. [ABSTRACT FROM AUTHOR]

Published
2025
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114. Automated pupillometry is a predictor of outcome of stroke patients: an observational, prospective, cohort study.

Author

Scala, Irene, Miccoli, Massimo, Giovanni, Jacopo Di, Cerulli, Fabiana, Rizzo, Pier A, Bellavia, Simone, Vitali, Francesca, Colò, Francesca, Abruzzese, Serena, Marca, Giacomo della, Guglielmi, Valeria, Brunetti, Valerio, Iorio, Riccardo Di, Broccolini, Aldobrando, Profice, Paolo, Calabresi, Paolo, Monforte, Mauro, and Frisullo, Giovanni

Published
2025
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115. Olfactory Impairment and Recovery in Zebrafish (Danio rerio) Following Cadmium Exposure.

Author

Motta, Chiara Maria, Carotenuto, Rosa, Fogliano, Chiara, Rosati, Luigi, Denre, Pabitra, Panzuto, Raffaele, Romano, Rossana, Miccoli, Gianluca, Simoniello, Palma, and Avallone, Bice

Subjects
POISONS, CADMIUM chloride, ZEBRA danio, FOOD chains, BODIES of water
Abstract

Simple Summary: Cadmium pollution, driven by human activities, is a significant stressor in aquatic ecosystems, bioaccumulating and biomagnifying in food chains. While its toxic effects on aquatic species' organs are well-documented, its impact on sensory systems, such as the olfactory system, remains understudied. This research focused on short-term exposure (96 h) to 25 µM cadmium chloride in adult zebrafish, evaluating structural and functional changes in their olfactory lamellae. Anthropic activities have significantly elevated cadmium levels, making it a significant stressor in aquatic ecosystems. Present in high concentrations across water bodies, cadmium is known to bioaccumulate and biomagnify throughout the food chain. While the toxic effects of cadmium on the organs and tissues of aquatic species are well-documented, little is known about its impact on sensory systems crucial for survival. Consequently, this study investigated the impact of short-term exposure (96 h) to 25 µM cadmium chloride on the olfactory system of adult zebrafish. The research aimed to assess structural and functional changes in the zebrafish's olfactory lamellae, providing a deeper understanding of how cadmium affects the sense of smell in this aquatic species. After exposure, cyto-anatomical alterations in the lamellae were analysed using light microscopy and immunocytochemistry. They revealed severe lamellar edema, epithelial thickening, and an increased number of apoptotic and crypt cells. Rodlet and goblet cells also increased by 3.5- and 2.5-fold, respectively, compared to control lamellae, and collagen density in the lamina propria increased 1.7-fold. Cadmium upregulated metallothioneins and increased the number of PCNA-positive cells. The olfactory function was assessed through a behavioural odour recognition test, followed by a recovery phase in which zebrafish exposed to cadmium were placed in clean water for six days. The exposed fish performed poorly, failing to reach food in five consecutive trials. However, lamellar damage was reduced after the recovery period, and their performance improved, becoming comparable to the control group. These results suggest that cadmium disrupts the sense of smell, and that recovery is possible after short-term exposure. This evidence sheds light on aspects of animal survival that are often overlooked when assessing environmental pollution. [ABSTRACT FROM AUTHOR]

Published
2025
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124. Mechanical Characterization of Adobe Masonry

Author

Oliveira, Cristina, Silveira, Dora, Varum, Humberto, Parisi, Fulvio, Miccoli, Lorenzo, Solís, Mario, Rodríguez-Mariscal, José D., Tarque, Nicola, de Freitas, Vasco Peixoto, Series Editor, Costa, Aníbal, Series Editor, Delgado, João M. P. Q., Series Editor, Varum, Humberto, editor, Parisi, Fulvio, editor, Tarque, Nicola, editor, and Silveira, Dora, editor

Published
2021
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125. Mechanical Characterization of Adobe Bricks

Author

Silveira, Dora, Oliveira, Cristina, Varum, Humberto, Ioannou, Ioannis, Miccoli, Lorenzo, Tarque, Nicola, Parisi, Fulvio, Fenu, Luigi, Solís, Mario, Rodríguez-Mariscal, José D., de Freitas, Vasco Peixoto, Series Editor, Costa, Aníbal, Series Editor, Delgado, João M. P. Q., Series Editor, Varum, Humberto, editor, Parisi, Fulvio, editor, Tarque, Nicola, editor, and Silveira, Dora, editor

Published
2021
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129. Prelinguistic intersubjective and socio-communicative skills in infants with neurodevelopmental disabilities aged 0–36 months: A new assessment and parent support tool

Author

Sandra Strazzer, Daniela Sacchi, Roberta Rigamonti, Annalisa Miccoli, Margherita Bonino, Serena Giancola, Chiara Germiniasi, and Rosario Montirosso

Subjects
neurodevelopmental disabilities, early intervention, intersubjectivity, socio-communicative skills, parental support, Other systems of medicine, RZ201-999, Medical technology, R855-855.5
Abstract

BackgroundAlthough children with neurodevelopmental disability (NDD) present with several deficits, they partially share developmental impairments in prelinguistic intersubjective and socio-communicative skills, which are not easily assessed by conventional tests during the first years of life.AimThe current paper presents a new procedure to assess the prelinguistic intersubjective and socio-communicative skills of NDD children aged 0–36 months. A specific observation form template, called the Observation of Prelinguistic Intersubjective and Socio-Communicative Skills (OPISCoS) form, has been designed to systematically detect infant skills during daily routines (e.g., mealtime, playtime, desk activities). The OPISCoS form helps speech therapists to provide parents support to better perceive and understand early communicative signals from their children, avoiding the risk of excessive or reduced social stimulation.MethodsThe OPISCoS form is composed of three sections, namely, “Pragmatics and Communication,” “Decoding,” and “Expression,” which are useful to delineate the communication abilities of children with NDD and are not tapped by traditional batteries. Vignettes from clinical practice illustrate and provide exemplifications for using the OPISCoS form with NDD infants and their parents.ResultsThe OPISCoS form was reported for two children and showed potential in detecting disrupted communicative behaviors and planning specific early interventions. Further, we observed an improvement not only in children's communicative abilities improve but also in their interactions with parents. From a clinical point of view, the OPISCoS form (1) offers an observational perspective of prelinguistic intersubjective and socio-communicative skills in infants with NDD and (2) may be useful to practitioners to enhance parents’ sensitivity to their infants’ communicative behavior.ConclusionThe OPISCoS form was developed in clinical practice and is based on a very preliminary description of a new observational procedure as integration for the assessment of NDD children. The OPISCoS form appears to be a useful tool for the clinical assessment of prelinguistic intersubjective and socio-communicative skills in NDD infants as well as for promoting the quality of early parenting.

Published
2023
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138. First World Consensus Conference on pancreas transplantation: Part II – recommendations

Author

Boggi, Ugo, Vistoli, Fabio, Andres, Axel, Arbogast, Helmut P., Badet, Lionel, Baronti, Walter, Bartlett, Stephen T., Benedetti, Enrico, Branchereau, Julien, Burke, George W., 3rd, Buron, Fanny, Caldara, Rossana, Cardillo, Massimo, Casanova, Daniel, Cipriani, Federica, Cooper, Matthew, Cupisti, Adamasco, Davide, Josè, Drachenberg, Cinthia, de Koning, Eelco J.P., Ettorre, Giuseppe Maria, Fernandez Cruz, Laureano, Fridell, Jonathan A., Friend, Peter J., Furian, Lucrezia, Gaber, Osama A., Gruessner, Angelika C., Gruessner, Rainer W.G., Gunton, Jenny E., Han, Duck-Jong, Iacopi, Sara, Kauffmann, Emanuele Federico, Kaufman, Dixon, Kenmochi, Takashi, Khambalia, Hussein A., Lai, Quirino, Langer, Robert M., Maffi, Paola, Marselli, Lorella, Menichetti, Francesco, Miccoli, Mario, Mittal, Shruti, Morelon, Emmanuel, Napoli, Niccolò, Neri, Flavia, Oberholzer, Jose, Odorico, Jon S., Öllinger, Robert, Oniscu, Gabriel, Orlando, Giuseppe, Ortenzi, Monica, Perosa, Marcelo, Perrone, Vittorio Grazio, Pleass, Henry, Redfield, Robert R., Ricci, Claudio, Rigotti, Paolo, Paul Robertson, R., Ross, Lainie F., Rossi, Massimo, Saudek, Frantisek, Scalea, Joseph R., Schenker, Peter, Secchi, Antonio, Socci, Carlo, Sousa Silva, Donzilia, Squifflet, Jean Paul, Stock, Peter G., Stratta, Robert J., Terrenzio, Chiara, Uva, Pablo, Watson, Christopher J.E., White, Steven A., Marchetti, Piero, Kandaswamy, Raja, and Berney, Thierry

Published
2021
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144. Neurobiological outcomes of cognitive behavioral therapy for obsessive-compulsive disorder: A systematic review

Author

Andrea Poli, Andrea Pozza, Graziella Orrù, Ciro Conversano, Rebecca Ciacchini, Daniele Pugi, Nicole Loren Angelo, Lorenzo Lucherini Angeletti, Mario Miccoli, and Angelo Gemignani

Subjects
obsessive-compulsive disorder, functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy, neuroimaging, Positron emission tomography (PET), cognitive behavior therapy (CBT), Psychiatry, RC435-571
Abstract

IntroductionObsessive-compulsive disorder (OCD) is characterized by recurrent distressing thoughts and repetitive behaviors, or mental rituals performed to reduce anxiety. Recent neurobiological techniques have been particularly convincing in suggesting that cortico-striatal-thalamic-cortico (CSTC) circuits, including orbitofrontal cortex (OFC) and striatum regions (caudate nucleus and putamen), are responsible for mediation of OCD symptoms. However, it is still unclear how these regions are affected by OCD treatments in adult patients. To address this yet open question, we conducted a systematic review of all studies examining neurobiological changes before and after first-line psychological OCD treatment, i.e., cognitive-behavioral therapy (CBT).MethodsStudies were included if they were conducted in adults with OCD and they assessed the neurobiological effects of CBT before and after treatment. Two databases were searched: PsycINFO and PubMed for the time frame up to May 2022.ResultsWe obtained 26 pre-post CBT treatment studies performed using different neurobiological techniques, namely functional magnetic resonance imaging (fMRI), Positron emission tomography (PET), regional cerebral blood flow (rCBF), 5-HT concentration, magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), Electroencephalography (EEG). Neurobiological data show the following after CBT intervention: (i) reduced activations in OFC across fMRI, EEG, and rCBF; (ii) decreased activity in striatum regions across fMRI, rCBF, PET, and MRI; (iii) increased activations in cerebellum (CER) across fMRI and MRI; (iv) enhanced neurochemical concentrations in MRS studies in OFC, anterior cingulate cortex (ACC) and striatum regions. Most of these neurobiological changes are also accompanied by an improvement in symptom severity as assessed by a reduction in the Y-BOCS scores.ConclusionCognitive-behavioral therapy seems to be able to restructure, modify, and transform the neurobiological component of OCD, in addition to the clinical symptoms. Nevertheless, further studies are necessary to frame the OCD spectrum in a dimensional way.

Published
2022
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145. The use of NAMs and omics data in risk assessment

Author

Andrea Miccoli, Philip Marx‐Stoelting, and Albert Braeuning

Subjects
New Approach Methods, Animal experiment, Omics, Risk assessment, 3Rs principle, Workshop, Nutrition. Foods and food supply, TX341-641, Chemical technology, TP1-1185
Abstract

Abstract The animal‐centric approach so far predominantly employed in risk assessment has been questioned in recent years due to a number of shortcomings regarding performance, consistency, transferability of results, sustainability, costs and ethical reasons. Alternatives to animal testing, collectively termed NAMs, may have the potential to deliver sound, cost‐effective, prompt and reliable information, but their regulatory acceptance has not been established yet. The main reasons behind this are mostly related to actual methodological obstacles, with particular reference to addressing complex endpoints such as repeated‐dose toxicity, the issue of translating the concept of adversity to NAMs, and doubts of stakeholders about the level of chemical safety ensured by NAMs. With the aim of providing an updated view on major conceptual and methodological developments in the field of toxicology, a symposium and a workshop were organised by the German Federal Institute for Risk Assessment (Bundesinstitut für Risikobewertung, BfR) and Helmholtz Centre for Environmental Research on 15–17 November 2021 in Berlin. The conference, entitled ‘Challenges in Public Health Protection in the 21st Century: New Methods, Omics and Novel Concepts in Toxicology’ brought together eminent scientists with representatives from industry and regulatory authorities. The organisation, day‐to‐day operations and the reporting of the event main outcomes in a position paper were the main focus of the present EFSA EU‐FORA work programme. Tasks pertaining to ‘The use of NAMs and omics data in risk assessment’ were implemented under the shared supervision of units ‘Testing and Assessment Strategies Pesticides’ and ‘Effect‐based Analytics and Toxicogenomics’ of the German Federal Institute for Risk Assessment.

Published
2022
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148. The spatial diffusion of fertility decline in Egypt (1950–2006)

Author

Yoann Doignon, Elena Ambrosetti, and Sara Miccoli

Subjects
Spatial diffusion, Fertility decline, Egypt, Spatial pattern, Spatial autocorrelation, Demography. Population. Vital events, HB848-3697
Abstract

Abstract While the Egyptian fertility transition has been widely addressed in the literature, few researches have studied the spatial dimension of fertility. Using population census data, the aim of this study is to describe and measure the evolution of the geography of fertility on a subnational scale (qism/markaz), focusing on the period between 1960 and 2006. We assumed that the decline in fertility had spread spatially through Egypt, the spatial diffusion occurring through two traditional mechanisms: contagion and hierarchical diffusion. Our results confirm our hypotheses and highlight the importance of studying the spatial diffusion of the fertility transition. This study is unique for the Egyptian context given the long period and fine territorial scale considered. Our study constitutes an important addition to the existing group of studies on the spatial diffusion of fertility. Finally, it contributes to gaining further insight into a demographic dynamic which is fundamental for the future of Egypt.

Published
2021
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149. I libri, l’esilio

Author

Miccoli, Dario

Subjects
mediterranean, books, jewish history, sephardi jews, migration, diaspora, Social Sciences, Social history and conditions. Social problems. Social reform, HN1-995
Abstract

This essay discusses the role that books have had for the Jews living on the southern shore of the Mediterranean during colonial and postcolonial times, reconstructing some of the textual encounters that led me to conduct research on these issues. Books are considered as objects that talk about histories of belonging, exile and migration and that move from one place to another, pass from one person to another, and are lost and found again, objects for which we feel affection or that sometimes we want to give away. Mixing historical analysis with ego-historical reflections on my own research path, the essay looks at books as mirrors of the plurality of (Jewish) identities and memories that can be traced in the Mediterranean until the 1950s and 1960s and, in different ways, until today.

Published
2021
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150. Emotional reactivity to binge food and erotic cues in women with bulimia nervosa symptoms

Author

Isabel Hernández-Rivero, Jens Blechert, Laura Miccoli, Katharina Naomi Eichin, M. Carmen Fernández-Santaella, and Rafael Delgado-Rodríguez

Subjects
Bulimia nervosa, Binge food cues, Erotic cues, Psychophysiology, Valence, Startle reflex, Psychiatry, RC435-571
Abstract

Abstract Background Studies on food cue reactivity have documented that altered responses to high-calorie food are associated with bulimic symptomatology, however, alterations in sexual motivations and behaviors are also associated clinical features in this population, which justify their inclusion as a research target. Here, we study responses to erotic cues—alongside food, neutral and aversive cues—to gain an understanding of specificity to food versus a generalized sensitivity to primary reinforcers. Methods We recorded peripheral psychophysiological indices –the startle reflex, zygomaticus, and corrugator responses—and self-reported emotional responses (valence, arousal, and dominance) in 75 women completing the Bulimia Test-Revised (BULIT-R). Multiple regression analysis tested whether BULIT-R symptoms were predicted by self-reported and psychophysiological responses to food versus neutral and erotic versus neutral images. Results The results showed that individuals with higher bulimic symptoms were characterized by potentiated eye blink startle response during binge food (vs. neutral images) and more positive valence ratings during erotic (vs. neutral) cues. Conclusions The results highlight the negative emotional reactivity of individuals with elevated bulimic symptoms toward food cues, which could be related to the risk of progression to full bulimia nervosa and thereby addressed in prevention efforts. Results also point to the potential role of reactivity to erotic content, at least on a subjective level. Theoretical models of eating disorders should widen their conceptual scope to consider reactivity to a broader spectrum of primary reinforcers, which would have implications for cue exposure-based treatments. Plain English summary We examined appetitive and aversive cue responses in college women to investigate how bulimic symptoms relate to primary reinforcers such as food and erotic images. We recorded peripheral psychophysiological indices (the startle reflex, zygomaticus, and corrugator responses) and self-reported emotional responses (valence, arousal, and dominance) in 75 college women that were presented with the Spanish version of the Bulimia Test-Revised. The results showed that bulimic symptoms increase both psychophysiological defensiveness toward food cues and subjective pleasure toward erotic cues. The findings suggest a generalized sensitivity to primary reinforcers in the presence of bulimic symptoms, and emphasize the relevance of adopting a wider framework in research and treatment on bulimia nervosa.

Published
2021
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