1051. [Studies on coumarins from fruit of Cnidium monnieri and their cytotoxic activities].
- Author
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Duan XH, Zhang YZ, He P, Ma ZM, and Pei L
- Subjects
- Animals, Cell Line, Tumor, Cell Proliferation drug effects, Cnidium toxicity, Coumarins chemistry, Coumarins isolation & purification, Drugs, Chinese Herbal chemistry, Drugs, Chinese Herbal isolation & purification, Fruit toxicity, Mice, Molecular Structure, Cnidium chemistry, Coumarins toxicity, Drugs, Chinese Herbal toxicity, Fruit chemistry
- Abstract
This study is to study is to investigate the coumarins from Fruit of Cnidium monnieri and their cytotoxic activities. The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. The isolated compounds were evaluated for their cytoxic activities by MTT method. Eleven compounds were isolated and identified as osthole (1), bergaptan (2), xanthotoxol (3), xanthotoxin (4), imperatorin (5), isopimpinellin (6), osthenol (7), psoralen (8), 5,7-dimethoxycoumarin (9), oxypeucedaninhydrate (10), and swietenocoumarin F (11). Compounds 7, 9-11 were isolated from the Cnidium genus for the first time. Compounds 1,5,10 and 11 showed significant cytotoxic activities against L1210 cell lines at a concentration of 1 x 10(-5) mol x L(-1) with inhibitory rates of were 70.13, 63.10, 55.77, and 75.08% respectively.
- Published
- 2015