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[Studies on coumarins from fruit of Cnidium monnieri and their cytotoxic activities].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2015 Sep; Vol. 40 (18), pp. 3594-7. - Publication Year :
- 2015
-
Abstract
- This study is to study is to investigate the coumarins from Fruit of Cnidium monnieri and their cytotoxic activities. The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. The isolated compounds were evaluated for their cytoxic activities by MTT method. Eleven compounds were isolated and identified as osthole (1), bergaptan (2), xanthotoxol (3), xanthotoxin (4), imperatorin (5), isopimpinellin (6), osthenol (7), psoralen (8), 5,7-dimethoxycoumarin (9), oxypeucedaninhydrate (10), and swietenocoumarin F (11). Compounds 7, 9-11 were isolated from the Cnidium genus for the first time. Compounds 1,5,10 and 11 showed significant cytotoxic activities against L1210 cell lines at a concentration of 1 x 10(-5) mol x L(-1) with inhibitory rates of were 70.13, 63.10, 55.77, and 75.08% respectively.
- Subjects :
- Animals
Cell Line, Tumor
Cell Proliferation drug effects
Cnidium toxicity
Coumarins chemistry
Coumarins isolation & purification
Drugs, Chinese Herbal chemistry
Drugs, Chinese Herbal isolation & purification
Fruit toxicity
Mice
Molecular Structure
Cnidium chemistry
Coumarins toxicity
Drugs, Chinese Herbal toxicity
Fruit chemistry
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 40
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 26983206