Objective: To examine patients who presented to the emergency department following motorcycle accidents before and during the COVID-19 pandemic period in order to comparatively assess the incidence of these accidents, associated trauma severity, and patient outcomes. Methods: In this retrospective observational study, we evaluated 1,137 patients who presented to the Adult Emergency Department of Bakırköy Dr. Sadi Konuk Training and Research Hospital with injuries caused by motorcycle accidents. The electronic files of the patients who were determined to have presented to the emergency department after a motorcycle accident were screened, and their age, gender, blood pressure, pulse, oxygen saturation, respiratory rate, body temperature (at presentation), time of the accident, motorcycle speed at the time of the accident as reported by the driver, protective equipment used, time of arrival at the emergency department, length of stay in the emergency department and hospital, the types of treatment applied throughout the patients’ stay, and the outcomes of the patients were recorded in the case forms. Results: Of the 1135 patients included in the study, 129 (11.4%) presented to the emergency department before the pandemic and 1,006 (88.6%) during the pandemic period. There were 1,055 (93%) male patients and 80 (7%) female patients. Of all the patients, 145 (12.9%) were hospitalized, and 990 (87.2%) left the hospital. Of those who left the emergency room, 42 (3.7%) refused treatment, and 35 (3.1%) left without the physician’s approval. Of the hospitalized patients, 20 (1.8%) were admitted to the intensive care unit, and four (0.4%) were referred to other hospitals. Upon examination of in-hospital mortality, it was determined that 1,132 (99.7%) patients survived, and three (0.3%) died. When assessing the association between injury locations according to the use of full-body protective equipment, a correlation was found in terms of head and neck, lung, extremity, pelvis, and multi-trauma injuries. Conclusion: Regardless of traffic density, the use of protective equipment by motorcycle drivers prevents serious injuries in accidents. The EMTRAS and ESI scores are clinical prediction tools that can be used to predict mortality and morbidity in motorcycle accidents [ABSTRACT FROM AUTHOR]