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The integration of deep learning in medical image analysis is a transformative leap in healthcare, impacting diagnosis and treatment significantly. This scholarly review explores deep learning's applications, revealing limitations in traditional methods while showcasing its potential. It delves into tasks like segmentation, classification, and enhancement, highlighting the pivotal roles of Convolutional Neural Networks (CNNs) and Generative Adversarial Networks (GANs). Specific applications, like brain tumor segmentation and COVID-19 diagnosis, are deeply analyzed using datasets like NIH Clinical Center's Chest X-ray dataset and BraTS dataset, proving invaluable for model training. Emphasizing high-quality datasets, especially in chest X-rays and cancer imaging, the article underscores their relevance in diverse medical imaging applications. Additionally, it stresses the managerial implications in healthcare organizations, emphasizing data quality and collaborative partnerships between medical practitioners and data scientists. This review article illuminates deep learning's expansive potential in medical image analysis, a catalyst for advancing healthcare diagnostics and treatments. [ABSTRACT FROM AUTHOR]

In the domain of clinical imaging, the exact and quick identification proof of bone fractures plays a crucial part in a pivotal role in facilitating timely and effective patient care. This research tends to this basic need by harnessing the force of profound learning, explicitly utilizing a convolutional neural network (CNN) model as the foundation of our technique. The essential target of our study was to improve the mechanized recognition of bone fractures in X-ray images, utilizing the capacities of deep learning algorithms. The use of a CNN model permitted us to successfully capture and learn intricate patterns and features within the X-ray images, empowering the framework to make exact fracture detections. The training process included presenting the model to a various dataset, guaranteeing its versatility to an extensive variety of fracture types. The results of our research show the excellent performance of the CNN model in fracture detection, where our model has achieved an average precision of 89.5%, an average recall of 87%, and an overall accuracy of 91%. These metrics assert the vigour of our methodology and highlight the capability of deep learning in medical image analysis. [ABSTRACT FROM AUTHOR]

Since the unexpected upsurge of the severe acute respiratory syndrome coronavirus 2 (COVID-19) in 2019, it has rapidly spread all over the world. This viral pandemic has dramatically affected human health and daily life. Recent advances in artificial intelligence (AI) techniques are considered key enablers to expediting COVID-19 detection issues. In particular, the development of high-performance deep learning (DL) models with high levels of accuracy is a significant step towards a fast and high-precision method for the detection and diagnosis of COVID-19 infected patients. This paper proposes a convolutional neural network (CNN) model for the classification of COVID-19 positive infected and negative/normal patients. This model is applied to a dataset consisting of 3,000 chest X-ray images in 2 classes of diagnoses– COVID-19 and normal. The CNN is implemented via a Keras framework with a hyperparameter tuning technique, and a data augmentation technique is performed to achieve the best accuracy. Experimentally, the confusion matrix, precision-recall curve, and receiver operating characteristic curve (ROCC) are utilized to analyze the performance of the CNN model. Experimental results demonstrate that the CNN provides a high-performance classification of COVID-19 patients with a testing accuracy of 99% and a testing loss rate of 0.034. The Precision, Recall, F1-score, and the area under the ROCC for this model are 99.02%, 98.97%, 99%, and 100%, respectively. This model applied to X-ray images provides a quick and accurate approach to distinguishing between normal negative cases and COVID-19 infected patients, and should aid doctors and radiologists in the screening of COVID-19 patients. [ABSTRACT FROM AUTHOR]

Lung cancer is a prevalent malignancy associated with a high mortality rate, with a 5-year relative survival rate of 23%. Traditional survival analysis methods, reliant on clinician judgment, may lack accuracy due to their subjective nature. Consequently, there is growing interest in leveraging AI-based systems for survival analysis using clinical data and medical imaging. The purpose of this study is to improve survival classification for lung cancer patients by utilizing a 3D-CNN architecture (ResNet-34) applied to CT images from the NSCLC-Radiomics dataset. Through comprehensive ablation studies, we evaluate the effectiveness of different features and methodologies in classification performance. Key contributions include the introduction of a novel feature (GTV1-SliceNum), the proposal of a novel loss function (PEN-BCE) accounting for false negatives and false positives, and the showcasing of their efficacy in classification. Experimental work demonstrates results surpassing those of the existing literature, achieving a classification accuracy of 0.7434 and an ROC-AUC of 0.7768. The conclusions of this research indicate that the AI-driven approach significantly improves survival prediction for lung cancer patients, highlighting its potential for enhancing personalized treatment strategies and prognostic modeling. [ABSTRACT FROM AUTHOR]

Medical image segmentation is a crucial field of computer vision. Obtaining correct pathological areas can help clinicians analyze patient conditions more precisely. We have observed that both CNN-based and attention-based neural networks often produce rough segmentation results around the edges of the regions of interest. This significantly impacts the accuracy of obtaining the pathological areas. Without altering the original data and model architecture, further refining the initial segmentation outcomes can effectively address this issue and lead to more satisfactory results. Recently, diffusion models have demonstrated outstanding results in image generation, showcasing their powerful ability to model distributions. We believe that this ability can greatly enhance the accuracy of the reshaping results. This research proposes ERSegDiff, a neural network based on the diffusion model for reshaping segmentation borders. The diffusion model is trained to fit the distribution of the target edge area and is then used to modify the segmentation edge to produce more accurate segmentation results. By incorporating prior knowledge into the diffusion model, we can help it more accurately simulate the edge probability distribution of the samples. Moreover, we introduce the edge concern module, which leverages attention mechanisms to produce feature weights and further refine the segmentation outcomes. To validate our approach, we employed the COVID-19 and ISIC-2018 datasets for lung segmentation and skin cancer segmentation tasks, respectively. Compared with the baseline model, ERSegDiff improved the dice score by 3%–4% and 2%–4%, respectively, and achieved state-of-the-art scores compared to several mainstream neural networks, such as swinUNETR. [ABSTRACT FROM AUTHOR]

Early intervention in tumors can greatly improve human survival rates. With the development of deep learning technology, automatic image segmentation has taken a prominent role in the field of medical image analysis. Manually segmenting kidneys on CT images is a tedious task, and due to the diversity of these images and varying technical skills of professionals, segmentation results can be inconsistent. To address this problem, a novel ASD-Net network is proposed in this paper for kidney and kidney tumor segmentation tasks. First, the proposed network employs newly designed Adaptive Spatial-channel Convolution Optimization (ASCO) blocks to capture anisotropic information in the images. Then, other newly designed blocks, i.e., Dense Dilated Enhancement Convolution (DDEC) blocks, are utilized to enhance feature propagation and reuse it across the network, thereby improving its segmentation accuracy. To allow the network to segment complex and small kidney tumors more effectively, the Atrous Spatial Pyramid Pooling (ASPP) module is incorporated in its middle layer. With its generalized pyramid feature, this module enables the network to better capture and understand context information at various scales within the images. In addition to this, the concurrent spatial and channel squeeze & excitation (scSE) attention mechanism is adopted to better comprehend and manage context information in the images. Additional encoding layers are also added to the base (U-Net) and connected to the original encoding layer through skip connections. The resultant enhanced U-Net structure allows for better extraction and merging of high-level and low-level features, further boosting the network's ability to restore segmentation details. In addition, the combined Binary Cross Entropy (BCE)-Dice loss is utilized as the network's loss function. Experiments, conducted on the KiTS19 dataset, demonstrate that the proposed ASD-Net network outperforms the existing segmentation networks according to all evaluation metrics used, except for recall in the case of kidney tumor segmentation, where it takes the second place after Attention-UNet. [ABSTRACT FROM AUTHOR]

Accurate and automated segmentation of brain tissue images can significantly streamline clinical diagnosis and analysis. Manual delineation needs improvement due to its laborious and repetitive nature, while automated techniques encounter challenges stemming from disparities in magnetic resonance imaging (MRI) acquisition equipment and accurate labeling. Existing software packages, such as FSL and FreeSurfer, do not fully replace ground truth segmentation, highlighting the need for an efficient segmentation tool. To better capture the essence of cerebral tissue, we introduce nnSegNeXt, an innovative segmentation architecture built upon the foundations of quality assessment. This pioneering framework effectively addresses the challenges posed by missing and inaccurate annotations. To enhance the model's discriminative capacity, we integrate a 3D convolutional attention mechanism instead of conventional convolutional blocks, enabling simultaneous encoding of contextual information through the incorporation of multiscale convolutional features. Our methodology was evaluated on four multi-site T1-weighted MRI datasets from diverse sources, magnetic field strengths, scanning parameters, temporal instances, and neuropsychiatric conditions. Empirical evaluations on the HCP, SALD, and IXI datasets reveal that nnSegNeXt surpasses the esteemed nnUNet, achieving Dice coefficients of 0.992, 0.987, and 0.989, respectively, and demonstrating superior generalizability across four distinct projects with Dice coefficients ranging from 0.967 to 0.983. Additionally, extensive ablation studies have been implemented to corroborate the effectiveness of the proposed model. These findings represent a notable advancement in brain tissue analysis, suggesting that nnSegNeXt holds the promise to significantly refine clinical workflows. [ABSTRACT FROM AUTHOR]

Medical diagnosis can be severely hindered by distorted medical images, especially in the analysis of Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) images. Therefore, enhancing the accuracy of diagnostic imaging and inpainting damaged areas are essential for medical diagnosis. Over the past decade, image inpainting techniques have advanced due to deep learning and multimedia information. In this paper, we proposed a deep convolutional autoencoder network with improved parameters as a robust method for inpainting non-anatomical objects in MRI and CT images. Traditional approaches based on the exemplar methods are much less effective than deep learning methods in capturing high-level features. However, the inpainted regions would appear blurr and with global inconsistency. To handle the fuzzy problem, we enhanced the network model by introducing skip connections between mirrored layers in the encoder and decoder stacks. This allowed the generative process of the inpainting region to directly use the low-level feature information of the processed image. To provide both pixel-accurate and local-global contents consistency, the proposed model is trained with a combination of the typical pixel-wise reconstruction loss and two adversarial losses, which makes the inpainted output seem more realistic and consistent with its surrounding contexts. As a result, the proposed approach is much faster than existing methods while providing unprecedented qualitative and quantitative evaluation with a high inpainting inception score of 10.58, peak signal-to-noise ratio (PSNR) 52.44, structural similarity index (SSIM) 0.95, universal image quality index (UQI) 0.96, and mean squared error (MSE) 40.73 for CT and MRI images. This offers a promising avenue for enhancing image fidelity, potentially advancing clinical decision-making and patient care in neuroimaging practice. [ABSTRACT FROM AUTHOR]

The convergence of digital pathology and artificial intelligence could assist histopathology image analysis by providing tools for rapid, automated morphological analysis. This systematic review explores the use of artificial intelligence for histopathological image analysis of digitised central nervous system (CNS) tumour slides. Comprehensive searches were conducted across EMBASE, Medline and the Cochrane Library up to June 2023 using relevant keywords. Sixty‐eight suitable studies were identified and qualitatively analysed. The risk of bias was evaluated using the Prediction model Risk of Bias Assessment Tool (PROBAST) criteria. All the studies were retrospective and preclinical. Gliomas were the most frequently analysed tumour type. The majority of studies used convolutional neural networks or support vector machines, and the most common goal of the model was for tumour classification and/or grading from haematoxylin and eosin‐stained slides. The majority of studies were conducted when legacy World Health Organisation (WHO) classifications were in place, which at the time relied predominantly on histological (morphological) features but have since been superseded by molecular advances. Overall, there was a high risk of bias in all studies analysed. Persistent issues included inadequate transparency in reporting the number of patients and/or images within the model development and testing cohorts, absence of external validation, and insufficient recognition of batch effects in multi‐institutional datasets. Based on these findings, we outline practical recommendations for future work including a framework for clinical implementation, in particular, better informing the artificial intelligence community of the needs of the neuropathologist. [ABSTRACT FROM AUTHOR]

This paper focuses on improving automated approaches to glaucoma diagnosis, a severe disease that leads to gradually narrowing vision and potentially blindness due to optic nerve damage occurring without the patient's awareness. Early diagnosis is crucial. By utilizing advanced deep learning technologies and robust image processing capabilities, this study employed four types of input data (retina fundus image, region of interest (ROI), vascular region of interest (VROI), and color palette images) to reflect structural issues. We addressed the issue of data imbalance with a modified loss function and proposed an ensemble model based on the vision large language model (VLLM), which improved the accuracy of glaucoma classification. The results showed that the models developed for each dataset achieved 1% to 10% higher accuracy and 8% to 29% improved sensitivity compared to conventional single-image analysis. On the REFUGE dataset, we achieved a high accuracy of 0.9875 and a sensitivity of 0.9. Particularly in the ORIGA dataset, which is challenging in terms of achieving high accuracy, we confirmed a significant increase, with an 11% improvement in accuracy and a 29% increase in sensitivity. This research can significantly contribute to the early detection and management of glaucoma, indicating potential clinical applications. These advancements will not only further the development of glaucoma diagnostic technologies but also play a vital role in improving patients' quality of life. [ABSTRACT FROM AUTHOR]

Diabetic retinopathy (DR) is the primary factor leading to vision impairment and blindness in diabetics. Uncontrolled diabetes can damage the retinal blood vessels. Initial detection and prompt medical intervention are vital in preventing progressive vision impairment. Today's growing medical field presents a more significant workload and diagnostic demands on medical professionals. In the proposed study, a convolutional neural network (CNN) is employed to detect the stages of DR. This research is crucial for studying DR because of its innovative methodology incorporating two different public datasets. This strategy enhances the model's capacity to generalize unseen DR images, as each dataset encompasses unique demographics and clinical circumstances. The network can learn and capture complicated hierarchical image features with asymmetric weights. Each image is preprocessed using contrast-limited adaptive histogram equalization and the discrete wavelet transform. The model is trained and validated using the combined datasets of Dataset for Diabetic Retinopathy and the Asia-Pacific Tele-Ophthalmology Society. The CNN model is tuned in with different learning rates and optimizers. An accuracy of 72% and an area under curve score of 0.90 was achieved by the CNN model with the Adam optimizer. The recommended study results may reduce diabetes-related vision impairment by early identification of DR severity. [ABSTRACT FROM AUTHOR]

Medical image analysis has witnessed significant advancements with deep learning techniques. In the domain of brain tumor segmentation, the ability to precisely delineate tumor boundaries from magnetic resonance imaging (MRI) scans holds profound implications for diagnosis. This study presents an ensemble convolutional neural network (CNN) with transfer learning, integrating the state-of-the-art Deeplabv3+ architecture with the ResNet18 backbone. The model is rigorously trained and evaluated, exhibiting remarkable performance metrics, including an impressive global accuracy of 99.286%, a high-class accuracy of 82.191%, a mean intersection over union (IoU) of 79.900%, a weighted IoU of 98.620%, and a Boundary F1 (BF) score of 83.303%. Notably, a detailed comparative analysis with existing methods showcases the superiority of our proposed model. These findings underscore the model's competence in precise brain tumor localization, underscoring its potential to revolutionize medical image analysis and enhance healthcare outcomes. This research paves the way for future exploration and optimization of advanced CNN models in medical imaging, emphasizing addressing false positives and resource efficiency. [ABSTRACT FROM AUTHOR]

Breast cancer is a major public health concern, and early detection and classification are essential for improving patient outcomes. However, breast tumors can be difficult to distinguish from benign tumors, leading to high false positive rates in screening. The reason is that both benign and malignant tumors have no consistent shape, are found at the same position, have variable sizes, and have high correlations. The ambiguity of the correlation challenges the computer-aided system, and the inconsistency of morphology challenges an expert in identifying and classifying what is positive and what is negative. Due to this, most of the time, breast cancer screen is prone to false positive rates. This research paper presents the introduction of a feature enhancement method into the Google inception network for breast cancer detection and classification. The proposed model preserves both local and global information, which is important for addressing the variability of breast tumor morphology and their complex correlations. A locally preserving projection transformation function is introduced to retain local information that might be lost in the intermediate output of the inception model. Additionally, transfer learning is used to improve the performance of the proposed model on limited datasets. The proposed model is evaluated on a dataset of ultrasound images and achieves an accuracy of 99.81%, recall of 96.48%, and sensitivity of 93.0%. These results demonstrate the effectiveness of the proposed method for breast cancer detection and classification. [ABSTRACT FROM AUTHOR]

Brain tumor classification using MRI images is a crucial yet challenging task in medical imaging. Accurate diagnosis is vital for effective treatment planning but is often hindered by the complex nature of tumor morphology and variations in imaging. Traditional methodologies primarily rely on manual interpretation of MRI images, supplemented by conventional machine learning techniques. These approaches often lack the robustness and scalability needed for precise and automated tumor classification. The major limitations include a high degree of manual intervention, potential for human error, limited ability to handle large datasets, and lack of generalizability to diverse tumor types and imaging conditions.To address these challenges, we propose a federated learning-based deep learning model that leverages the power of Convolutional Neural Networks (CNN) for automated and accurate brain tumor classification. This innovative approach not only emphasizes the use of a modified VGG16 architecture optimized for brain MRI images but also highlights the significance of federated learning and transfer learning in the medical imaging domain. Federated learning enables decentralized model training across multiple clients without compromising data privacy, addressing the critical need for confidentiality in medical data handling. This model architecture benefits from the transfer learning technique by utilizing a pre-trained CNN, which significantly enhances its ability to classify brain tumors accurately by leveraging knowledge gained from vast and diverse datasets.Our model is trained on a diverse dataset combining figshare, SARTAJ, and Br35H datasets, employing a federated learning approach for decentralized, privacy-preserving model training. The adoption of transfer learning further bolsters the model's performance, making it adept at handling the intricate variations in MRI images associated with different types of brain tumors. The model demonstrates high precision (0.99 for glioma, 0.95 for meningioma, 1.00 for no tumor, and 0.98 for pituitary), recall, and F1-scores in classification, outperforming existing methods. The overall accuracy stands at 98%, showcasing the model's efficacy in classifying various tumor types accurately, thus highlighting the transformative potential of federated learning and transfer learning in enhancing brain tumor classification using MRI images. [ABSTRACT FROM AUTHOR]

Advancements in clinical treatment are increasingly constrained by the limitations of supervised learning techniques, which depend heavily on large volumes of annotated data. The annotation process is not only costly but also demands substantial time from clinical specialists. Addressing this issue, we introduce the S4MI (Self-Supervision and Semi-Supervision for Medical Imaging) pipeline, a novel approach that leverages advancements in self-supervised and semi-supervised learning. These techniques engage in auxiliary tasks that do not require labeling, thus simplifying the scaling of machine supervision compared to fully-supervised methods. Our study benchmarks these techniques on three distinct medical imaging datasets to evaluate their effectiveness in classification and segmentation tasks. Notably, we observed that self-supervised learning significantly surpassed the performance of supervised methods in the classification of all evaluated datasets. Remarkably, the semi-supervised approach demonstrated superior outcomes in segmentation, outperforming fully-supervised methods while using 50% fewer labels across all datasets. In line with our commitment to contributing to the scientific community, we have made the S4MI code openly accessible, allowing for broader application and further development of these methods. The code can be accessed at https://github.com/pranavsinghps1/S4MI. [ABSTRACT FROM AUTHOR]

A prompt diagnosis of breast cancer in its earliest phases is necessary for effective treatment. While Computer-Aided Diagnosis systems play a crucial role in automated mammography image processing, interpretation, grading, and early detection of breast cancer, existing approaches face limitations in achieving optimal accuracy. This study addresses these limitations by hybridizing the improved quantum-inspired binary Grey Wolf Optimizer with the Support Vector Machines Radial Basis Function Kernel. This hybrid approach aims to enhance the accuracy of breast cancer classification by determining the optimal Support Vector Machine parameters. The motivation for this hybridization lies in the need for improved classification performance compared to existing optimizers such as Particle Swarm Optimization and Genetic Algorithm. Evaluate the efficacy of the proposed IQI-BGWO-SVM approach on the MIAS dataset, considering various metric parameters, including accuracy, sensitivity, and specificity. Furthermore, the application of IQI-BGWO-SVM for feature selection will be explored, and the results will be compared. Experimental findings demonstrate that the suggested IQI-BGWO-SVM technique outperforms state-of-the-art classification methods on the MIAS dataset, with a resulting mean accuracy, sensitivity, and specificity of 99.25%, 98.96%, and 100%, respectively, using a tenfold cross-validation datasets partition. [ABSTRACT FROM AUTHOR]

This study addresses the critical challenge of detecting brain tumors using MRI images, a pivotal task in medical diagnostics that demands high accuracy and interpretability. While deep learning has shown remarkable success in medical image analysis, there remains a substantial need for models that are not only accurate but also interpretable to healthcare professionals. The existing methodologies, predominantly deep learning-based, often act as black boxes, providing little insight into their decision-making process. This research introduces an integrated approach using ResNet50, a deep learning model, combined with Gradient-weighted Class Activation Mapping (Grad-CAM) to offer a transparent and explainable framework for brain tumor detection. We employed a dataset of MRI images, enhanced through data augmentation, to train and validate our model. The results demonstrate a significant improvement in model performance, with a testing accuracy of 98.52% and precision-recall metrics exceeding 98%, showcasing the model's effectiveness in distinguishing tumor presence. The application of Grad-CAM provides insightful visual explanations, illustrating the model's focus areas in making predictions. This fusion of high accuracy and explainability holds profound implications for medical diagnostics, offering a pathway towards more reliable and interpretable brain tumor detection tools. [ABSTRACT FROM AUTHOR]

Deep semi-supervised learning (DSSL) is a machine learning paradigm that blends supervised and unsupervised learning techniques to improve the performance of various models in computer vision tasks. Medical image classification plays a crucial role in disease diagnosis, treatment planning, and patient care. However, obtaining labeled medical image data is often expensive and time-consuming for medical practitioners, leading to limited labeled datasets. DSSL techniques aim to address this challenge, particularly in various medical image tasks, to improve model generalization and performance. DSSL models leverage both the labeled information, which provides explicit supervision, and the unlabeled data, which can provide additional information about the underlying data distribution. That offers a practical solution to resource-intensive demands of data annotation, and enhances the model's ability to generalize across diverse and previously unseen data landscapes. The present study provides a critical review of various DSSL approaches and their effectiveness and challenges in enhancing medical image classification tasks. The study categorized DSSL techniques into six classes: consistency regularization method, deep adversarial method, pseudo-learning method, graph-based method, multi-label method, and hybrid method. Further, a comparative analysis of performance for six considered methods is conducted using existing studies. The referenced studies have employed metrics such as accuracy, sensitivity, specificity, AUC-ROC, and F1 score to evaluate the performance of DSSL methods on different medical image datasets. Additionally, challenges of the datasets, such as heterogeneity, limited labeled data, and model interpretability, were discussed and highlighted in the context of DSSL for medical image classification. The current review provides future directions and considerations to researchers to further address the challenges and take full advantage of these methods in clinical practices. [ABSTRACT FROM AUTHOR]

Deep learning has achieved great success in academic benchmarks but fails to work effectively in the real world due to the potential dataset bias. The current learning methods are prone to inheriting or even amplifying the bias present in a training dataset and under-represent specific demographic groups. More recently, some dataset debiasing methods have been developed to address the above challenges based on the awareness of protected or sensitive attribute labels. However, the number of protected or sensitive attributes may be considerably large, making it laborious and costly to acquire sufficient manual annotation. To this end, we propose a prototype-based network to dynamically balance the learning of different subgroups for a given dataset. First, an object pattern embedding mechanism is presented to make the network focus on the foreground region. Then we design a prototype learning method to discover and extract the visual patterns from the training data in an unsupervised way. The number of prototypes is dynamic depending on the pattern structure of the feature space. We evaluate the proposed prototype-based network on three widely used polyp segmentation datasets with abundant qualitative and quantitative experiments. Experimental results show that our proposed method outperforms the CNN-based and transformer-based state-of-the-art methods in terms of both effectiveness and fairness metrics. Moreover, extensive ablation studies are conducted to show the effectiveness of each proposed component and various parameter values. Lastly, we analyze how the number of prototypes grows during the training process and visualize the associated subgroups for each learned prototype. The code and data will be released at https://github.com/zijinY/dynamic-prototype-debiasing. [ABSTRACT FROM AUTHOR]

The wide application of deep learning techniques has strongly promoted the development of the medical image analysis field. Most deep learning methods usually assume that the training and test sets are independent and identically distributed. However, the assumption is problematic to guarantee when the model. Resulting in the dilemma of model performance degradation and poor scene generalization ability. Deep learning-based domain adaptation techniques are the mainstream methods for improving model migration ability, which aims to enable the model trained on one dataset to obtain better results on another dataset with no or only a small amount of labels. Due to the difficulties in sample acquisition and labelling, unique image properties and modal differences in medical images, it brings many practical challenges to domain adaptive technology. This paper firstly introduced the definition and primary challenges of the domain adaptation and then classified and summarized related algorithms in recent years from a technical point of view, compared and analyzed their advantages and disadvantages, and then introduced the medical image datasets commonly used in domain adaptation and related algorithm results in detail. Finally, this paper prospected the future research direction of domain adaptation for medical image analysis regarding development bottlenecks, technical means, and cross-cutting areas. [ABSTRACT FROM AUTHOR]

IntroductionEarly detection of pancreatic cancer continues to be a challenge due to the difficulty in accurately identifying specific signs or symptoms that might correlate with the onset of pancreatic cancer. Unlike breast or colon or prostate cancer where screening tests are often useful in identifying cancerous development, there are no tests to diagnose pancreatic cancers. As a result, most pancreatic cancers are diagnosed at an advanced stage, where treatment options, whether systemic therapy, radiation, or surgical interventions, offer limited efficacy.MethodsA two-stage weakly supervised deep learning-based model has been proposed to identify pancreatic tumors using computed tomography (CT) images from Henry Ford Health (HFH) and publicly available Memorial Sloan Kettering Cancer Center (MSKCC) data sets. In the first stage, the nnU-Net supervised segmentation model was used to crop an area in the location of the pancreas, which was trained on the MSKCC repository of 281 patient image sets with established pancreatic tumors. In the second stage, a multi-instance learning-based weakly supervised classification model was applied on the cropped pancreas region to segregate pancreatic tumors from normal appearing pancreas. The model was trained, tested, and validated on images obtained from an HFH repository with 463 cases and 2,882 controls.ResultsThe proposed deep learning model, the two-stage architecture, offers an accuracy of 0.907 ± 0.01, sensitivity of 0.905 ± 0.01, specificity of 0.908 ± 0.02, and AUC (ROC) 0.903 ± 0.01. The two-stage framework can automatically differentiate pancreatic tumor from non-tumor pancreas with improved accuracy on the HFH dataset.DiscussionThe proposed two-stage deep learning architecture shows significantly enhanced performance for predicting the presence of a tumor in the pancreas using CT images compared with other reported studies in the literature.