51. Identification of respiratory hazardous substances in cleaning products used in healthcare centres across England and Wales
- Author
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Lee, Sewon, Povey, Andrew, and Van Tongeren, Martie
- Subjects
Asthma ,Cleaning product ,Healthcare worker - Abstract
Exposure to cleaning and disinfectant products has been associated with respiratory disorders, such as asthma, in healthcare workers. Hazard identification of substances in cleaning products has mostly been made by safety data sheets (SDSs). However, respiratory hazards may not be identified well since SDSs are published with self-classification, and further potential hazards, such as secondary reaction products, may also exist. The aim of this study was to identify the respiratory hazards of substances in cleaning products that healthcare workers use. The database of 229 substances in 473 cleaning products, and their hazards, was developed based on information in SDSs from the NHS supply chain online catalogue. At least one SDS identified four respiratory sensitisers and twenty-five respiratory irritants. However, SDSs provided respiratory hazard information inconsistently. Only fourteen respiratory irritants (56%) were consistently labelled in all the SDSs. Although the European Chemicals Agency (ECHA) published a list of hazardous substances, three irritants in the ECHA list - glutaraldehyde, 2-phenoxyethanol, and methyloxirane - were not identified by any SDS. Also, ECHA-identified H-statements of over 40% hazardous substances on the ECHA list were not labelled in at least one SDS. The Quantitative Structure-Activity Relationship (QSAR) model and asthmagen list established by the United States Association of Occupational and Environmental Clinics (AOEC) were used to identify further respiratory hazardous substances; these methods identified fifty-one respiratory sensitisers and one respiratory irritant not apparent on any SDS. Based on the Master Chemical Mechanism (MCM) that provided a wide range of information on the degradation processes of a series of Volatile Organic Compounds (VOCs) and on hospital ventilation rates, seventeen reaction products were generated from seventeen substances in cleaning products. Formaldehyde and 3-isopropenyl-6-oxoheptanal (IPOH), were identified as respiratory hazardous reaction products by the QSAR model and the AOEC asthmagen list. In addition, the Cleaning and Hazardous Products Exposure Logging (CHaPEL) smartphone application was developed to collect information from cleaners and healthcare workers to better assess their exposure to hazards. The CHaPEL application was tested with eighteen university cleaners, and two respiratory hazardous chemicals - ethanolamine and alkyl (C12-16) dimethyl benzyl ammonium chloride - were identified. All the participants reported that it was easy to use the application. In conclusion, it was more challenging to identify respiratory sensitisers via SDSs than to identify irritants. Despite the usefulness of SDSs, they did not provide consistent hazard information for substances, and potential respiratory hazardous substances not suggested by SDSs may also be present in cleaning products. Also, further hazards, such as reaction products, may yet exist. Hence, healthcare workers may be exposed to not only more respiratory hazards not on SDSs, but also hazardous reaction products that have not yet been identified.
- Published
- 2023