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The adjacent interharmonic pairs or single adjacent interhamonic symmetrical to the fundamental/harmonic component can be caused by the large-scale grid connection of renewable energy. It is usually necessary to confirm the type of adjacent interharmonics to build an accurate calculation model when estimating the frequency components in electric signal. However, the spectrum leakage interferences caused by the grid frequency deviation makes that requirement hard to achieve. Towards the problem, an effective criterion to confirm the type of the adjacent interharmonics and an accurate estimation method of the harmonics and adjacent interharmonics based on the criterion even there is frequency deviation are proposed. Firstly, the spectrum leakage interferences are suppressed to obtain the adjacent interharmonic spectral lines by analysing the relationship of the frequency deviation and spectral lines. Then, the type criterion of the adjacent interharmonics is proposed by comparing the spectrum difference between each type of adjacent interharmonics. Finally, the spectral line equation for each type of adjacent interharmonics are constructed according to the confirmed type to accurately estimate the harmonics and adjacent interharmonics. Even there is frequency deviation, the type of the adjacent interharmnics can be confirmed accurately and a more precise estimation of the harmonics and adjacent interharmonics can be achieved with the proposed method. The accuracy of the proposed method is verified by the simulation.

Post-acidification is one of the most important factors affecting the sensory quality, flavor characteristics and stability of yogurt during shelf-life. Non-thermal treatments are novel methods to control post-acidification, which can maintain the original nutritional properties and sensory quality of food to the maximum extent. In this paper, the mechanism of post-acidification of lactic acid bacteria was reviewed. The mechanism and recent research progress of non-heat treatment processes such as ultra-high pressure, ultrasound, pulsed electric field, CO2 treatment, irradiation were analyzed and provided theoretical guidance for the development and industrial application of non-heat acid control technology.

Objective: To explore the risk factors of duodenogastric reflux (DGR) in relation to different dietary habits. Methods: A total of 106 patients with symptoms of DGR who underwent electronic gastroscopy from June 2019 to June 2020 were selected and divided into the DGR group (n = 33) and the non-DGR group (n = 73) according to the diagnosis of bile reflux. Questionnaires were used to collect the basic information and dietary habits of the patients, including age, gender, body mass index, place of residence, comorbidities, dietary composition, salt intake, smoking and drinking consumption. The total bile acid (TBA) and cholesterol (CHO) of the gastric juice were measured using a fully automated biochemical analyser, with an enzyme-linked immunosorbent assay used for the serum cholecystokinin, gastrin and gastrin levels. Univariate analysis and multivariate logistic regression analysis were used to predict the attendant DGR risk factors. Results: There was no significant difference in age or gender between the DGR and the non-DGR groups (P > 0.05). The proportion of patients living in the Bashang region was significantly higher in the DGR group (78.79%) than in the non-DGR group (38.36%) (P < 0.05). The levels of TBA and CHO in the gastric juice and the cholecystokinin and gastrin levels in the serum of the DGR group were higher than those in the non-DGR group, while the serum motilin levels were significantly lower in the DGR group than in the non-DGR group (P < 0.05). The univariate analysis indicated that the proportion of patients with daily consumption of dairy products and fried foods, a high salt intake and smoking and drinking consumption were significantly higher in the DGR than in the non-DGR group (P < 0.05). Conclusion: The daily consumption of dairy products and a preference for fried food are independent risk factors for the occurrence of DGR (odds ratio ≥ 1, P < 0.05).

Peizhuang Zhao,&ast; Jiajia Ning,&ast; Jun Huang,&ast; Binqian Wei, Zhen Wang, Xue Huang Department of Geriatrics and Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xue Huang, Department of Geriatrics and Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530000, People’s Republic of China, Email hb960305@163.comPurpose: Microrchidia 2 (MORC2) is a universally expressed molecule that has recently been identified as a chromatin modulator and elevated in many malignancies. However, its prognostic value and immunological role of MORC2 in colon adenocarcinoma (COAD) have never been illustrated.Methods: The clinical parameters and MORC2 expression datasets of COAD patients were obtained from The Cancer Genome Atlas (TCGA). Cancer and adjacent tissue specimens from surgically resected COAD patients were collected, and quantitative real-time PCR was used to detect MORC2 expression. Differentially expressed genes related to MORC2 were discovered and used for functional enrichment analysis. The diagnostic and prognostic values of MORC2 in COAD were conducted using receiver operating characteristics (ROC), Kaplan–Meier survival curve analysis, PrognoScan, Gene Expression Profiling Interactive Analysis (GEPIA) public databases and nomograms. Eventually, the association of MORC2 with tumor microenvironment was analyzed by using TIMER and GSVA package of R (v3.6.3).Results: MORC2 expression was upregulated in COAD tissues, and the RT-qPCR results further verified the reliability of our differential analysis at the transcriptional level. Additionally, higher expression of MORC2 was correlated to a poor prognosis for COAD patients. MORC2 was an independent prognostic factor for COAD and could be a diagnostic factor for early COAD. Furthermore, MORC2 expression was positively correlated with immune cells such as NK cells, TFH cells and so on.Conclusion: The findings demonstrated that overexpression of MORC2 was correlated with worse prognosis and immune infiltrates of COAD. MORC2 can serve as a reliable diagnostic and prognostic biomarker and a target of immunotherapy for COAD patients.Keywords: MORC2, colon adenocarcinoma, diagnosis, prognosis, immune cell infiltration, biomarker

Abstract Nanoparticles-based glues have recently been shown with substantial potential for hydrogel adhesion. Nevertheless, the transformative advance in hydrogel-based application places great challenges on the rapidity, robustness, and universality of achieving hydrogel adhesion, which are rarely accommodated by existing nanoparticles-based glues. Herein, we design a type of nanohesives based on the modulation of hydrogel mechanics and the surface chemical activation of nanoparticles. The nanohesives can form robust hydrogel adhesion in seconds, to the surface of arbitrary engineering solids and biological tissues without any surface pre-treatments. A representative application of hydrogel machine demonstrates the tough and compliant adhesion between dynamic tissues and sensors via nanohesives, guaranteeing accurate and stable blood flow monitoring in vivo. Combined with their biocompatibility and inherent antimicrobial properties, the nanohesives provide a promising strategy in the field of hydrogel based engineering.

BackgroundSubchannel codes constitute an important computational tool in the field of reactor thermo-hydraulics. Uncertainty analysis methods can be used to effectively identify and quantify the uncertainties of code input parameters and model assumptions, thus improving the reliability of the code so as to provide a more reliable reference for thermo-hydraulic parameter design.PurposeThis paper aims to present an uncertainty analysis of a 10 MW small lead-bismuth reactor in steady-state and transient loss-of-flow accident scenarios by using the subchannel code SUBCHANFLOW.MethodsFirst, a full reactor core subchannel was modeled, and the input parameters that affect the target parameters were identified. Second, the optimal Latin hypercubic sampling method was used for sampling within the distribution range of the input parameters, and the samples were imported into SUBCHANFLOW to obtain the uncertainty bands for the steady-state and transient loss-of-flow accident scenarios. Finally, gray correlation analysis was employed to evaluate the steady-state and transient sensitivities.ResultsThe computational results indicate that the uncertainty bands of the target parameters envelop the nominal values in both the transient and steady-state cases. In the transient case, the maximum temperature tolerance upper limit of the pellet is 674.55 ℃ and that of the cladding is 618.31 ℃. Further, the calculation accuracy of each parameter is essentially below 7%. The uncertainty in the target parameters mainly originates from parameters such as the inlet temperature, fuel rod height, outlet pressure, total power, and thermal conductivity of the cladding, with the inlet temperature having the most significant effect.ConclusionsThis study demonstrated the computational uncertainty of the SUBCHANFLOW code and the difference in the sensitivity of each parameter to the system response under the steady-state and transient loss-of-flow accident scenarios. The findings help further optimize and improve the design and operation strategy of lead-bismuth reactors, thus enhancing their safety and reliability.

The impact of ultrafine composite minerals (USCMs) on the long-term characteristics of cement-based materials was explored, revealing that USCMs significantly enhance the long-term mechanical strength of these materials and effectively mitigate mortar shrinkage. The findings demonstrated that the shrinkage could be reduced to as low as 0.11% by 90 d, representing a 95.1% decrease compared to the control group. The influence of USCMs on the hydration kinetics of cement was examined using quantitative X-ray diffraction (QXRD), thermogravimetric-differential thermogravimetry (TG-DTG), and scanning electron microscopy (SEM) analyses. The results, in conjunction with the QXRD and TG-DTG analyses, suggest that USCMs intensify the hydration of the C₂S and C₃S phases. Moreover, the pozzolanic reaction of the USCMs increases the concentration of the hydrated calcium silicate gel within the cement matrix during the later stages of hydration, altering the morphology of the hydration products. This not only improves the volume stability of the mortars, but also results in a denser structure for cement-based materials.

E-learning has become an emerging approach to delivering knowledge and information to students. It presents significant challenges to sharing and understanding learners' knowledge, inquiries, interest, and needs. Educational organizations are expected to apply the appropriate practice to address knowledge-sharing challenges in the e-learning environment. In this study, through a systematic literature review, we intend to identify and synthesize knowledge-sharing challenges and practices as well as classify the most discussed challenges and practices in various contextual settings. The findings classify the knowledge-sharing challenges and practices in e-learning from four perspectives: organization, individual, knowledge and technology. This study aims to build a knowledge base to support future research and effective knowledge-sharing practices in the e-learning environment.

The influence of thermal inertia of the furnace refractory on the peak regulation characteristics of a 300 MW circulating fluidized bed boiler (CFB) was studied by using a numerical calculation method. Based on the actual operation conditions of the boiler, the calculation results reveal that the thermal inertia of refractory is affected by its thermal conductivity and the thickness. Specifically, the thermal inertia of refractory decreases with the increasing thermal conductivity and decreasing refractory thickness. As a consequence, the time that required for the refractory to reach heat equilibrium decreases from 5 812 s to 3 426 s if the thermal conductivity of refractory increases from 1 W/(m⋅K) to 15 W/(m⋅K), while it increases from 3 267 s to 7 771 s if the thickness of refractory material increases from 30 mm to 90 mm. Practically in the presence of the traditional refractory in the CFB dense phase zone, the time required to achieve heat equilibrium state becomes 82, 65 and 60 min when the load of this CFB boiler rises from 50% to 100% with a rate of 1%/min, 2%/min and 3%/min. For a refractory with higher thermal conductivity, the equilibrium response time will be reduced to 65, 46 and 40 min, correspondingly. According to the calculation results, a formula for the heat absorption rate of refractory material was obtained. In addition, the influencing coefficient of the thermal inertia of refractory on coal feeding was also defined and calculated.

Traditional Chinese Medicine nursing outpatient clinic is an advanced nursing practice model characterized by the Traditional Chinese Medicine (TCM) culture. Adhering to the principles of holistic view of TCM and nursing by syndrome differentiation, it aims to meet diversified health needs of patients by providing TCM nursing techniques, and plays a unique role in disease prevention and healthcare. It is a continuation of high-quality nursing and embodiment of patient-centered nursing service. The establishment of TCM nursing outpatient clinic is helpful to promote the psychical and mental health of patients, maintain harmonious nurse-patient relationship, promote the specialization and precision in nursing and better meet the health needs of population. This paper summarized the establishment and practice of Traditional Chinese Medicine nursing outpatient clinic, and provided reference for future improvement of TCM nursing outpatient clinic. (中医护理门诊是一种具有中医药文化特色的高级护理实践模式, 以中医整体观和辨证施护为原则, 运用中医特色护理技术, 满足患者多元化的健康需求, 在疾病预防保健中发挥了独特的优势。中医特色护理门诊的开展是优质护理内涵的延续, 体现了以患者为中心的服务理念, 有利于促进患者身心健康, 有利于建立和谐的护患关系, 有利于促使护理学科向专业化、精细化发展, 能够更加满足人民群众的健康需求。本文归纳总结了科室中医护理门诊构建方案及实施经验, 为今后更佳完善中医护理门诊体系提供参考。)

ObjectiveTo further understand the factors that promote thrombosis in essential thrombocythemia （ET） that were not included in IPSET-thrombosis （International Prognostic Score of Thrombosis for ET）. MethodsA systematic evaluation was conducted on 292 studies by retrieving PubMed，Web of Science, and The Cochrane Library. The incidence and relative risk ratio （RR） of thrombosis in ET patients with different risk factors were calculated. The confidence levels for the outcome were analyzed in combination with RR values and recommendation scores (RS) to find the thrombotic risk factors in ET patients. ResultsOut of 9 risk factors that promoted ET thrombosis, there were 4 factors in IPSET-thrombosis, including history of thrombosis （35.0%, RR=3.30, 95% CI : 2.30-4.75）, JAK2V617F positive （21.0%, RR=2.28, 95%CI : 1.14-4.56）, age over 60 years old （ 22.4% , RR=1.95, 95%CI : 1.17-3.23） and cardiovascular risk factors （17.7%, RR =1.90, 95%CI : 1.08-3.35）. The remaining five risk factors, not listed in IPSET-thrombosis, included monoclonal type of ET based on X-chromosome inactivation pattern （XCIP, 30.6%, RR=4.49, 95% CI: 1.58-12.77）, high JAK2V617F burden （33.9%, RR=3.69, 95%CI: 1.70-7.99）, leukocytosis （18.7%, RR=3.05, 95%CI: 1.81-5.13）, MPL mutation （22.1%, RR=2.40, 95%CI: 1.08-5.33） and splenomegaly （25.6%, RR=1.76, 95%CI：1.29-2.40）. ConclusionAmong the risk factors promoting thrombosis in ET patients, five thrombotic risk factors not included in the IPSET-thrombosis have been identified.

Abstract Extracellular vesicles (EVs) play an important role in human and bovine milk composition. According to excellent published studies, it also exerts various functions in the gut, bone, or immune system. However, the effects of milk-derived EVs on skeletal muscle growth and performance have yet to be fully explored. Firstly, the current study examined the amino acids profile in human milk EVs (HME) and bovine milk EVs (BME) using targeted metabolomics. Secondly, HME and BME were injected in the quadriceps of mice for four weeks (1 time/3 days). Then, related muscle performance, muscle growth markers/pathways, and amino acids profile were detected or measured by grip strength analysis, rotarod performance testing, Jenner-Giemsa/H&E staining, Western blotting, and targeted metabolomics, respectively. Finally, HME and BME were co-cultured with C2C12 cells to detect the above-related indexes and further testify relative phenomena. Our findings mainly demonstrated that HME and BME significantly increase the diameter of C2C12 myotubes. HME treatment demonstrates higher exercise performance and muscle fiber densities than BME treatment. Besides, after KEGG and correlation analyses with biological function after HME and BME treatment, results showed L-Ornithine acts as a “notable marker” after HME treatment to affect mouse skeletal muscle growth or functions. Otherwise, L-Ornithine also significantly positively correlates with the activation of the AKT/mTOR pathway and myogenic regulatory factors (MRFs) and can also be observed in muscle and C2C12 cells after HME treatment. Overall, our study not only provides a novel result for the amino acid composition of HME and BME, but the current study also indicates the advantage of human milk on skeletal muscle growth and performance.

Owing to the feature of ultrahigh power density, the dielectric capacitors play an increasingly important role in the field of industrial production, basic scientific research, aerospace, and military industry in recent years. However, the relatively low energy storage density of the dielectric capacitors generally leads to their big sizes, which is difficult to meet the miniaturization requirements of future devices. Polymer-ceramic nanocomposites can combine high permittivity of the ceramic fillers and the excellent breakdown strength of the polymer matrix, thus achieving excellent energy storage performance. At present, developing the polymer-ceramic nanocomposites with high energy storage density is the key to realize the miniaturization goal of dielectric capacitors in the future. The current research progress of polymer-ceramic nanocomposites for energy storage capacitor applications from three perspectives was systematically summarized, including regulation of the nanofillers, optimization of the interfaces, and design of the multilayer composite structure. Notably, the influences of the dimension, size, species, hierarchical structure of the nanofillers, interface optimization methods such as surface modification and core-shell structure construction, as well as multilayer structure design such as sandwich structure and gradient structure on the permittivity, breakdown strength and the energy storage density of the nanocomposites were introduced in detail. Meanwhile, the structure-activity relationships between the microstructure of nanocomposites and their energy storage properties were further analyzed and discussed. Finally, based on the challenges and shortcomings of the current research, the important development directions of this field in the future were proposed, including selecting the new 2D nanofillers, enhancing the energy storage efficiency, employing multimode combined optimization strategy, and constructing the corresponding dielectric capacitors.

Abstract The relationship between muscle wasting and mortality risk in the general population remains unclear. Our study was conducted to examine and quantify the associations between muscle wasting and all‐cause and cause‐specific mortality risks. PubMed, Web of Science and Cochrane Library were searched until 22 March 2023 for main data sources and references of retrieved relevant articles. Prospective studies investigating the associations of muscle wasting with risks of all‐cause and cause‐specific mortality in the general population were eligible. A random‐effect model was used to calculate the pooled relative risk (RR) and 95% confidence intervals (CIs) for the lowest versus normal categories of muscle mass. Subgroup analyses and meta‐regression were performed to investigate the potential sources of heterogeneities among studies. Dose–response analyses were conducted to evaluate the relationship between muscle mass and mortality risk. Forty‐nine prospective studies were included in the meta‐analysis. A total of 61 055 deaths were ascertained among 878 349 participants during the 2.5‐ to 32‐year follow‐up. Muscle wasting was associated with higher mortality risks of all causes (RR = 1.36, 95% CI, 1.28 to 1.44, I2 = 94.9%, 49 studies), cardiovascular disease (CVD) (RR = 1.29, 95% CI, 1.05 to 1.58, I2 = 88.1%, 8 studies), cancer (RR = 1.14, 95% CI, 1.02 to 1.27, I2 = 38.7%, 3 studies) and respiratory disease (RR = 1.36, 95% CI, 1.11 to 1.67, I2 = 62.8%, 3 studies). Subgroup analyses revealed that muscle wasting, regardless of muscle strength, was significantly associated with a higher all‐cause mortality risk. Meta‐regression showed that risks of muscle wasting‐related all‐cause mortality (P = 0.06) and CVD mortality (P = 0.09) were lower in studies with longer follow‐ups. An approximately inverse linear dose–response relationship was observed between mid‐arm muscle circumference and all‐cause mortality risk (P

Objective The alpine region is the source area of many large rivers globally, and understanding river-groundwater interactions in the region is critical to the scientific management of watershed water resources. Due to the widespread occurrence of permafrost, the distribution and dynamics of riverbed taliks play a vital role in controlling river-groundwater exchange in alpine regions, leading to the complex, unique characteristics of the hydraulic relationship between them. However, there have been few investigations on river-groundwater interactions in alpine regions due to the harsh field conditions, and these available studies have dominantly used isotope and hydrochemical tracing methods, which are expensive and not accurate. Methods In this study, the low-cost and accurate temperature signal was used as a tracer to quantify the exchange between river and groundwater. A vertical 1D transient heat transport analytical model was used to quantify river-groundwater exchange rates at different depths. The spatiotemporal variations in river-groundwater interactions were analyzed using the temperature data measured by a distributed optical fibre sensing system. Results Results show a substantial spatiotemporal variation in the exchange between river and groundwater in alpine regions. Season and climate can control the exchange rate between river and groundwater, and even the direction of exchange. It is also found that the exchange rate of river and groundwater increases with the depth of the active layer. Conclusion The study indicates that the temperature tracing method is suitable for studying river-groundwater interactions in alpine areas dominated by permafrost. Furthermore, the combination of two temperature tracing methods can effectively improve the accuracy and provide a feasible research framework for alpine regions where hydrogeological data are scarce.

All-optical wavelength conversion based on four-wave mixing attracts intense interest in many areas, especially in optical fiber communications, due to the advantages of femtosecond response, modulation-format transparency, and high flexibility in optical network management. In this paper, we present the first optical translation of 32-GBaud 16QAM signals with an integrated Si3N4 nonlinear nanophotonic waveguide. An on-chip continuous-wave conversion efficiency of up to −0.6 dB from S band to C band is achieved in the dispersion-engineered low-loss Si3N4 nonlinear waveguide that is back-end compatible with complementary metal–oxide–semiconductor processes. The high conversion efficiency avoids the use of external optical amplifiers for signal demodulation. The converted idler is successfully received with a sensitivity penalty of less than 0.5 dB. Moreover, pre-amplifier-free multichannel wavelength conversion of over-100-Gbps coherent signals in C band is also demonstrated using the same Si3N4 nanophotonic waveguide via changing the pump wavelength, which shows good flexibility in all-optical signal processing. Additionally, wavelength conversion with a bandwidth over 100 nm can be expected by optimizing the current Si3N4 nanophotonic waveguide, which is promising for commercial coherent fiber communications and has bright prospects in various areas including optical signal processing, imaging, optical spectroscopy, and quantum optics.

Compared with traditional adhesive bonding and mechanical fastening, ultrasonic welding (USW) technology provides a new economical and efficient joining method for the manufacturing of fiber-reinforced polymeric composite (FRPC) structures.USW device system, process and welding principle of FRPCs, and the influence of USW process parameters and the type of energy director (ED) on the welding quality of thermoplastic composite (TPC) joint and their mechanism was systematically analyzed, and then discusses the realization ways of thermosetting composite (TSC) USW technology and the key factors affecting the quality of TSC-TSC and TSC-TPC welded joints were discussed. The development status of continuous USW technology and equipment meet the manufacturing requirements of large and complex FRPC structures were reviewed. The engineering applications of USW technology for FRPC in foreign aviation and automotive fields are summarized. And the engineering validation of USW technology has been completed abroad, while the research of USW technology in FRFC is still in its infancy in China. Therefore, the development of the USW technology of FRTP has become one of the key technologies to realize the large-scale assembly of CFRTP components, and it is also a long-term task of the future aircraft manufacturing technology.

Abstract Background Various approaches using epidural analgesia have been employed for relieving labor pain and promoting spontaneous delivery. We aimed to evaluate the effect of nalbuphine and ropivacaine versus fentanyl and ropivacaine on the duration of delivery in parturients. Methods Clinical data of 160 full-term primiparous women who received either nalbuphine or fentanyl in combination with ropivacaine infusion for epidural labor analgesia in our hospital from December 2020 to May 2022 were retrospectively analyzed. The participants were divided into two groups based on anesthesia methods: nalbuphine group (NR group, n = 78) received 0.2 mg/mL nalbuphine combined with 0.1% ropivacaine hydrochloride for patient-controlled epidural analgesia (PCEA) and fentanyl group (FR group, n = 82) received 2 ug/mL fentanyl citrate and 0.1% ropivacaine hydrochloride for PCEA. Both groups received an epidural blockade for labor analgesia at lumbar 2–3 interspace. The duration of the first, second, and third stages of labor, the onset of analgesia, and time before delivery (T0), 15 min of analgesia (T1), 30 min of analgesia (T2), full opening of the uterine opening (T3),exerts force during childbirth(T4), heart rate (HR), blood pressure (BP), blood saturation (SpO2), visual analogue pain scale (VAS) score, Ramsay sedation score, and modified Bromage score, and 5 min were recorded at 2 h postpartum (T5). The neonatal Apgar score, neonatal behavioral neurological assessment (NBNA) score, maternal nausea, vomiting, and itchy skin were recorded. Results Compared with the FR group, the first stage of labor duration (p

High temperature (HT) in-situ XRD method was adopted to investigate the calcium sulfoaluminate cement (CSA) or C4A3$ crystal architecture as well as its phases when passing through the temperature range of 20° to 70 °C. We examined the particle size analysis of the CSA ground powder when heated to different temperature (e.g., 35, 50, and 70 °C) in correlation with the HT X-ray diffraction (HT XRD) pattern as well with the compressive strength. The particle size of the lattice parameters increased during heating. The architecture transformation phase of the CSA took place at 50 °C. The transformation of the crystal cubic structure phase of the C4A3$ when passing from orthogonal to cubic space group was unstable with more heating (70 °C) and was adjustable. The C4A3$ compound's orthogonal and cubic crystal structures were clearly identified. The crystal structures were found to be responsible for the dehydration that occurred as the temperature rose and also for the decrease in compressive strength. The obtained final products of the C4A3$ were in cubic and orthogonal forms. The exothermic form of the C4A3$ was mostly observed at 20 °C and at 35 °C. The AFt and AFm crystal structure framework was constituted of AlO6 (in octahedral form) and AlO4 (in tetrahedral form).

Traditional Chinese Medicine (TCM) nursing clinic is an advanced nursing practice with Chinese characteristics. It takes the overall view of TCM and the principle, uses the characteristics of TCM nursing technology to meet the diversified health needs of patients, and plays a unique advantage in disease prevention and health care. TCM nursing clinic is able to improve patient satisfaction, broaden the scope of nursing services and enhance the professional level nursing. However, in the process of its development, there are also bottlenecks such as prescription right, inability to follow, and weak discipline development. The construction of Traditional Chinese Medicine Nursing Inheritance Studio is effective to drive the development of disciplines, develop the inheritance of TCM nursing, and realize mutual promotion and mutual development. (中医护理门诊是一种具有中国特色的高级护理实践模式, 其以中医的整体观和辨证施护为原则, 运用中医特色护理技术, 满足患者多元化的健康需求, 在疾病预防保健中发挥着独特优势。中医护理门诊能够提升患者满意度, 拓宽护理工作服务范围, 提升护理专业化水平。但是其发展过程中也有处方权、无法可依、学科发展薄弱等瓶颈, 中医护理传承工作室的建设, 可以有效带动学科发展, 发成中医护理传承, 实现相互促进相互发展。)

The strength prediction of pervious concrete is hard to implement for the mix design due to the porous structure. This work studied the influence of the water-to-cement ratio on the fluidity, viscosity, and mechanical properties of cement paste. Then, the porosity, permeability, and compressive strength of the pervious concrete with various porosities were investigated, and the test results were fitted and analyzed. The result indicates that as the water-to-cement ratio increases, the viscosity of the cement paste reduces and the fluidity increases. The water-to-cement ratio has a negative linear relationship with net slurry strength. The porosity and permeability of pervious concrete fluctuate in accordance with the same rule as the water-to-cement ratio changes. The compressive strength of pervious concrete with varying design porosities increases initially, then declines as the water-to-cement ratio rises. According to the linear fitting analysis, when the water-to-cement ratio is constant, the permeability and compressive strength of pervious concrete have a positive and negative linear relationship with the design porosity, respectively. By analyzing the fitting results and combining the volume method of pervious concrete, a calculation method for mix proportion design is proposed to predict the strength of pervious concrete.

Abstract Designing next‐generation molecular devices typically necessitates plentiful oxygen‐bearing sites to facilitate multiple‐electron transfers. However, the theoretical limits of existing materials for energy conversion and information storage devices make it inevitable to hunt for new competitors. Polyoxometalates (POMs), a unique class of metal‐oxide clusters, have been investigated exponentially due to their structural diversity and tunable redox properties. POMs behave as electron‐sponges owing to their intrinsic ability of reversible uptake‐release of multiple electrons. In this review, numerous POM‐frameworks together with desired features of a contender material and inherited properties of POMs are systematically discussed to demonstrate how and why the electron‐sponge‐like nature of POMs is beneficial to design next‐generation water oxidation/reduction electrocatalysts, and neuromorphic nonvolatile resistance‐switching random‐access memory devices. The aim is to converge the attention of scientists who are working separately on electrocatalysts and memory devices, on a point that, although the application types are different, they all hunt for a material that could exhibit electron‐sponge‐like feature to realize boosted performances and thus, encouraging the scientists of two completely different fields to explore POMs as imperious contenders to design next‐generation nanodevices. Finally, challenges and promising prospects in this research field are also highlighted.

Gymnastics learning is characterized by imitation and reference, and a teaching model combining optical sensors and image simulation systems may have promising results in college gymnastics courses. Based on the introduction of the meaning of college gymnastics teaching, the article sorted out the value performance of the image teaching mode and also established an optical three-dimensional imaging system based on optical sensors for gymnastics movement to obtain gymnastic images. In the optical 3D imaging system, the acquisition error of gymnastics images is reduced by using the finite distance image measurement method, and the quality of gymnastics images is enhanced by adaptive bilateral filtering and adaptive threshold selection of the Canny operator by the OTSU method. The enhanced gymnastics images are then inputted into a panoramic graphic imaging simulation system, and a gymnastics image simulation teaching model is established for colleges and universities. The effectiveness of the gymnastics image simulation teaching model is analyzed through a teaching comparison test conducted during simulation verification for optical imaging. In the optical imaging system, when the measurement distance is about 150m, the measurement error range is between [15″and 30″], and the MSE value of the gymnastic enhanced image obtained by the improved Canny algorithm decreases by 46.97% compared with the MSE value before the improvement. The students’ handstand score against the wall improved by 22.63 points compared to before the experiment, and more than 90% of the students were satisfied with the gymnastics image simulation teaching method. The teaching mode is constructed with the optical sensor to obtain the image characteristics of gymnastics movement, and the simulation system is innovative, which effectively promotes students’ interest in learning gymnastics courses and enhances their gymnastics training level.

The emergence of technological innovation in Dehua ceramics has brought new impetus to the spread of ceramic culture. By mining the market characteristics of ceramic technology innovation, we analyze the influencing factors of Dehua’s ceramic innovation development. Based on big data technology, this paper collects data related to the development of the Dehua ceramics industry, and after pre-processing the data, a classical division-based K-means clustering algorithm is used to make a division and explore the innovation characteristics of different Dehua ceramics industries. On this basis, correlation analysis and regression analysis were introduced to explore the influencing factors of innovative design and development in the Dehua ceramic industry. The second and third clusters in the purchase of innovatively designed Dehua ceramics accounted for 100% and 91%, respectively. It shows that the market demand for innovative design in Dehua Ceramics is large. The company type factor is the most critical influence factor for the development of innovative design in Dehua Ceramic Company, which can be changed by changing the type of company to promote the development of innovative design in the industry. The clustering result analysis in this paper accurately reflects the market characteristics of Dehua Ceramics, and the regression analysis accurately reflects the influence factors related to the development of innovative designs in the Dehua Ceramics industry.

AIGC has attracted much attention in the application of art and design professional fields and has gradually become an important auxiliary tool for art and design professionals creation. This paper utilizes AIGC as a starting point for design creativity and develops a text-guided image generation model based on AIGC, which employs a semantically consistent generative adversarial network. We compare different model indexes across different datasets to evaluate the image generation effect of the constructed model. Subsequently, we summarize and optimize the intelligent, creative workflow. Based on this workflow and the image generation model, we generate a series of images as an example of a cosmetic package. We then analyze the audience’s acceptance of these intelligently generated images through a questionnaire survey, thereby exploring the impact of AIGC-driven design and innovation. The GAN-SC model outperforms the comparison algorithms in various datasets, achieving an IS value higher than AttnGAN and DFGAN by 17.7% and 2.7%, respectively, and reducing the FID metrics by 29.43% and 19.6%, respectively. The acceptance rate of the AIGC-based design solution surpasses that of the traditional solution by 4.9%, and it excels across all design dimensions, showcasing the effectiveness of AIGC-driven design innovation.

In order to reveal the relationship between the integration of ice and snow sports virtual reality technology and the regional sports tourism economy, this paper establishes a structural equation model for ice and snow sports VR and sports tourism economy. Determine the latent variables and observed variables in the structural equation model (i.e., questionnaire items), take the online distribution of questionnaires to obtain the research data in this paper, and use the model in this paper to explore and analyze the integration of ice and snow sports virtual reality technology and regional sports tourism economies. The questionnaires developed in this paper meet the standard requirements of the reliability test, and the fitting indexes of the model have reached the state of conformity, as shown by the results. The path coefficients of the latent variable (VR experience quality) to the observed variables (Q11, Q12, Q13, Q14) are 0.555, 0.409, 0.344, and 0.348, respectively, and the non-standard coefficient of the quality of ice and snow sports VR experience (Q1) to the local sports tourism economy (Q4) is 0.941, P

Currently, most of the studies related to the integration of innovation and entrepreneurship education into the ideological and political work of college students are theoretical discussions, lacking empirical evidence and rarely quantitative analysis. Based on data technology, this paper explores the deep integration of innovation and entrepreneurship with college students’ ideological and political education. After mining the significance of the integration of innovation and entrepreneurship and college students’ civic and political education, the study utilizes the Bayesian theory and face recognition model to assess the effect of the deep integration of civic innovation and entrepreneurship education from the perspective of emotional change. Its algorithmic model, which is mainly based on classification criteria, recognizes students’ classroom expressions according to the classroom expression classification criteria and the emotion score calculation formula so as to judge the effect of students’ classroom listening. Through empirical analysis, all dimensions of ideological and political education self-efficacy and entrepreneurial values of innovation and entrepreneurship are significantly positively correlated at the level of 0.01. The average value of emotion scores of innovation and entrepreneurship education classes integrating ideological and political education is higher than that of traditional innovation and entrepreneurship classes by 0.04 and by 4 more students. The innovative entrepreneurship classroom integrated with Civic and Political Education has achieved good teaching results among college students.

In response to the problem of gas extraction pipeline damage and leakage inspection, a spiral mine pipeline inspection robot with pipeline inspection and motion control functions is designed. The structure and inspection and control system scheme of the robot are introduced. A mechanical analysis model is established for the operation of robots in pipelines, and the factors affecting the robot's traction performance are studied through dynamic simulation. The results show that the traction force of the robot during operation in the pipeline is related to the pipeline material, spiral angle, and the normal force between the pipeline wall and the driving wheel. The optimal spiral angle for robots operating in pipelines of different materials is different. When operating in pipelines of the same material, the traction force is higher in the absence of medium transportation than in the presence of medium transportation. The traction force of the robot increases with the increase of normal force. But there is no significant change in the optimal spiral angle. As the spiral angle increases, the traction force first increases and then decreases, reaching its maximum at a spiral angle of 40°. To improve the performance of robots passing through curved pipes, a variable spiral angle bending strategy is proposed. The robot actively controls the spiral angle to change in a sinusoidal pattern with the rotation of the spiral motion unit, so that the spiral angle on the inner side of the pipeline is smaller than that on the outer side. A robot testing platform to test the mine pipeline inspection robot is established. The results show that the optimal spiral angle for the robot to operate in the straight pipe is 40°. The traction performance of the robot can be improved by increasing the normal force. When using the variable spiral angle bending strategy, the robot has better performance and stability in passing through curved pipes compared to fixed spiral angle bending.

This paper arranges suitable land use types according to the quality characteristics of land parcel units, obtains the objective function of optimal land use allocation, and constructs a multi-objective constraint system in the process of land use planning. The integer vector is used to encode the land use types and represent the spatial distribution of land use, combined with the particle swarm algorithm to calculate its adaptability, speed and position update based on the initial population size and construct the land use optimization allocation model based on the constraint system. The particle swarm algorithm is used to explore the geographic environment and climate resources, the economy of the natural economy of the study area, and Landsat TM remote sensing image technology is used to obtain the initial data on the land use of the study area and empirical analysis is carried out on the optimization of the allocation of urban land use in the study area. The results show that the algorithm converges faster and achieves global convergence when the parameter is set to the fourth state, and the comprehensive suitability evaluation function achieves global convergence at generation 73, with a value of 1.64E+08, which is faster than the convergence of parameter settings 1 and 2 as well as 3. The land types that increase in area include garden land, forest land, transportation land, and water and water conservancy facilities land, which increase by 0.8%, 2.84%, 0.14%, and 0.8%, respectively, which protects the arable land and restricts the expansion of the construction land in terms of the quantitative structure. This study enriches the content and methods of optimizing land use space allocation, which helps to rationalize the use of land resources.

Background . Characteristics of X-linked Alport syndrome (XLAS) in a cohort of Chinese children. Methods . This work is a retrospective study covering the clinical information, pathological data, and gene sequencing results of 32 cases with XLAS from 2011 to 2022. Results . Among these 32 patients, the youngest age of onset was 3 months. Renal biopsy was performed on 29 children. The lamellated glomerular basement membrane was observed in 19 children using electron microscopy (65.5%). Of the 26 samples tested, 73.1% were found to be negative for collagen-a5 under immunohistochemical staining, showing clinical significance. Next-generation sequencing (NGS) detected 27 pathogenic gene mutations. A total of 15.4% of patients carried de novo mutations. Conclusions . The boys with XLAS showed more typical pathological performance than the girls. Patients with severe mutation were more likely to have proteinuria and hearing impairment. Renal pathology combined with NSG is an important means of diagnosis of AS.

Ablation failures of buffer layer in high voltage cross-linked polyethylene (XLPE) cables occur frequently, which has attracted widespread attention in the industry. The optimization of cable structure is conducive to solving the problem of discharge ablation. From the perspective of the discharge burn mechanism of buffer layer, the finite element model of cable is established for electric field simulation to analyze and discuss the variation of air gap electric field distribution under different structural parameters, thus designing and studying the structure optimization scheme. The results show that, on the premise of satisfying the design requirements of cable, it is beneficial to reduce the air gap electric field distortion because of poor contact, by reducing the thickness of the buffer layer and corrugated depth, as well as increasing extrusion depth between the metal sheath and the buffer layer. The smooth aluminum sleeve structure has low contact resistance with the buffer layer, so it has advantages in restraining fault of buffer layer discharge ablation.

ABSTRACTSynbiotics are increasingly used by the general population to boost immunity. However, there is limited evidence concerning the immunomodulatory effects of synbiotics in healthy individuals. Therefore, we conducted a double-blind, randomized, placebo-controlled study in 106 healthy adults. Participants were randomly assigned to receive either synbiotics (containing Bifidobacterium lactis HN019 1.5 × 108 CFU/d, Lactobacillus rhamnosus HN001 7.5 × 107 CFU/d, and fructooligosaccharide 500 mg/d) or placebo for 8 weeks. Immune parameters and gut microbiota composition were measured at baseline, mid, and end of the study. Compared to the placebo group, participants receiving synbiotic supplementation exhibited greater reductions in plasma C-reactive protein (P = 0.088) and interferon-gamma (P = 0.008), along with larger increases in plasma interleukin (IL)-10 (P = 0.008) and stool secretory IgA (sIgA) (P = 0.014). Additionally, synbiotic supplementation led to an enrichment of beneficial bacteria (Clostridium_sensu_stricto_1, Lactobacillus, Bifidobacterium, and Collinsella) and several functional pathways related to amino acids and short-chain fatty acids biosynthesis, whereas reduced potential pro-inflammatory Parabacteroides compared to baseline. Importantly, alternations in anti-inflammatory markers (IL-10 and sIgA) were significantly correlated with microbial variations triggered by synbiotic supplementation. Stratification of participants into two enterotypes based on pre-treatment Prevotella-to-Bacteroides (P/B) ratio revealed a more favorable effect of synbiotic supplements in individuals with a higher P/B ratio. In conclusion, this study suggested the beneficial effects of synbiotic supplementation on immune parameters, which were correlated with synbiotics-induced microbial changes and modified by microbial enterotypes. These findings provided direct evidence supporting the personalized supplementation of synbiotics for immunomodulation.

Diabetes mellitus (DM) is a chronic metabolic disorder that affects multiple organs and systems, including the pulmonary system. Pulmonary dysfunction in DM patients has been observed and studied for years, but the underlying mechanisms have not been fully understood. In addition to traditional mechanisms such as the production and accumulation of advanced glycation end products (AGEs), angiopathy, tissue glycation, oxidative stress, and systemic inflammation, recent studies have focused on programmed cell deaths (PCDs), especially the non-apoptotic ones, in diabetic pulmonary dysfunction. Non-apoptotic PCDs (NAPCDs) including autophagic cell death, necroptosis, pyroptosis, ferroptosis, and copper-induced cell death have been found to have certain correlations with diabetes and relevant complications. The AGE–AGE receptor (RAGE) axis not only plays an important role in the traditional pathogenesis of diabetes lung disease but also plays an important role in non-apoptotic cell death. In this review, we summarize novel studies about the roles of non-apoptotic PCDs in diabetic pulmonary dysfunction and focus on their interactions with the AGE–RAGE axis.

A high belite sulfoaluminate cement clinker containing a magnesia-alumina spinel was prepared using industrial solid waste and high-magnesium limestone. The preparation procedure and the influence of the trace elements on the clinker were specifically investigated. This study reveals the mechanism of the clinker formation. The appropriate firing temperature of the clinker and holding time were determined to be 1300 °C and 60 min - 90 min, respectively. The presence of MgO and SO₃ displayed a positive effect on the clinker formation at high temperatures. In addition, the excessive MgO in the raw material was solidified to create the stable inertia mineral MgAl₂O₄, which eliminated the delaying expansion hazard of MgO.

This study dealt with the use of gold tailings, red mud, bauxite, desulfurised gypsum and high magnesium limestone as the raw materials in the production of a belite sulfoaluminate cement clinker containing MgAl₂O₄. The hydration and early mechanical properties of this cement were characterised by isothermal calorimetry, a mechanical test, X-ray diffraction and a thermal analysis. The results showed that the optimal calcination temperature to obtain a satisfactory clinker strength was 1350 °C and the corresponding 1, 3 and 7-day strengths were 27.7, 45.8 and 54.3 MPa, respectively. The initial and final setting times of the cements range between 20 and 31 minutes. The cements had the characteristics of rapid hardening and the main hydration products were AFt, AFm and AH₃. The total hydration heat release of this cement within the first 50 hours was only 158J/g, which could effectively avoid the generation of internal cracks in the cement and has the potential to be applied to large concrete projects. Furthermore, the MgAl₂O₄ mineral phase was inert in the belite sulfoaluminate cement and did not participate in the hydration reaction, which eliminates the disadvantage of MgO in the cement systems and potentially increases the use of high magnesium limestone in cement production.

The two-peptide (class IIb) bacteriocins are generally thermostable small-molecule (< 10 kDa) two-component antimicrobial peptides produced by Gram-positive bacteria. This class of peptides mainly rely on peptide-peptide interactions mediated by typical motifs to form active dimeric transmembrane proteins. Numerous studies have shown that two-peptide bacteriocins have reliable safety and desirable bacteriostatic effect, holding great potential in the control of drug-resistant bacteria. Therefore, the structural features and action mechanisms of two-peptide bacteriocins have received considerable research attention. From the perspectives of the structure formation of two-peptide bacteriocins, peptide-peptide interaction, and peptide-membrane interaction, this article summarizes the mechanism of action of this class of antimicrobial peptides. Meanwhile, the structural regularity of two-peptide bacteriocins and the structural features affecting their activities are elaborated by synthesizing current research. This review will provide new ideas for future research on two-peptide bacteriocins.

Cell-free circulating tumor DNA (ctDNA) is synthesized by tumor cells, including metastatic tumors, and circulates in the bloodstream. Evidence suggests that ctDNA is a potential predictive and prognostic biomarker for colorectal cancer (CRC), but its predictive efficacy in detecting CRC liver metastasis (CLM) remains unclear. Additionally, its utility in the clinical setting needs further investigation. We conducted a meta-analysis to determine the utility of ctDNA as a biomarker for predicting the prognosis of CLM and investigate the relationship between CLM and ctDNA positivity. A literature search was performed in electronic databases to identify relevant studies published up to March 19, 2022. We retrieved data on overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) for both ctDNA-positive and ctDNA-negative colorectal liver metastasis (CLM) patients from the selected articles. Hazard ratios (HRs) were also calculated for these survival outcomes analysis was also performed. The stability of the combined meta-analysis was verified by sensitivity analysis and publication bias evaluation. Ten trials were included, and 615 patients were evaluated. In patients with CLM, pooled HRs revealed a substantial link between ctDNA positivity and RFS/DFS. Subgroup analysis revealed that ctDNA had a prospective detection value. Sensitivity analysis and publication bias evaluation indicated stable results. Although the results on pooled HR for OS suggested that ctDNA-positive patients had a shorter survival time, their pooled HRs had a relatively evident heterogeneity, and sensitivity analysis and publication bias evaluation indicated that pooled HRs were extremely unstable. In conclusion, our results demonstrate that ctDNA appears to be a prognostic biomarker for resectable CLM patients.

Jun Huang,&ast; Peizhuang Zhao,&ast; Jialing Shi, Jiajia Ning, Zhen Wang, Yihua Luo, Jingqian Qin, Xue Huang Department of Geriatrics and Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xue Huang, Department of Geriatrics and Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530000, People’s Republic of China, Email hb960305@163.comPurpose: Prolyl 4-hydroxylase subunit alpha 3 (P4HA3) has been proven to participate in the occurrence and development of multiple cancers. However, the functional role of P4HA3 in the tumor immune microenvironment (TIME) of colon adenocarcinoma (COAD) and the prognosis of COAD patients has not been clarified. This study aimed to elucidate the immunological role and prognostic value of P4HA3 in COAD.Methods: P4HA3 expression in COAD tissues was analyzed via experiments and a bioinformatics algorithm. Based on the COAD patients in The Cancer Genome Atlas database, we comprehensively evaluated whether the expression levels of P4HA3 affected clinical prognosis, TIME, and immunotherapy of COAD using the R platforms and several public databases, including GEPIA, TIMER, TISIDB, and TCIA.Results: The results of the pan-cancer analysis indicated that P4HA3 expression was significantly different in most tumor tissues compared with normal tissues. P4HA3 was overexpressed in COAD tissues, and overexpression of P4HA3 was associated with a worse overall survival and a shorted progression-free interval in COAD patients. The expression of P4HA3 was positively correlated with pathological stage, T stage, N stage, perineural infiltration, and lymphatic infiltration. There were significant correlations of P4HA3 expression levels with immune cell infiltration and their makers, as well as immunomodulators, chemokines, and microsatellite status. Moreover, overexpression of P4HA3 was associated with a lower response rate to immunotherapy in the IMvigor210 cohort.Conclusion: Overexpression of P4HA3 is closely related to the poor prognosis of COAD patients, and P4HA3 is a potential target for immunotherapy in COAD patients.Keywords: P4HA3, colon adenocarcinoma, prognosis, immunotherapy, tumor immune microenvironment

Postoperative cognitive dysfunction (POCD) is a common complication of cognitive decline after surgery and anesthesia. Sevoflurane, as a commonly used anesthetic, was found to cause POCD. Nudix Hydrolase 21 (NUDT21), a conserved splicing factor, has been reported to exert important functions in multiple diseases’ progression. In this study, the effect of NUDT21 on sevoflurane-induced POCD was elucidated. Results showed that NUDT21 was down-regulated in the hippocampal tissue of sevoflurane-induced rats. Morris water maze test results revealed that overexpression of NUDT21 improved sevoflurane-induced cognitive impairment. In addition, TUNEL assay results indicated that enhanced NUDT21 alleviated sevoflurane-induced apoptosis of hippocampal neurons. Furthermore, overexpression of NUDT21 suppressed the sevoflurane-induced LIMK2 expression. Taken together, NUDT21 alleviates sevoflurane-induced neurological damage in rats by down-regulating LIMK2, providing a novel target for the prevention of sevoflurane-induced POCD.

In order to study the dynamic evolution law of the pressure relief gas reservoir in the mining of extra-thick coal seams, the 3DEC numerical simulation software was used to analyze the stress and displacement distribution law of the overburden rock caused by mining, and the evolution characteristics of the pressure relief gas reservoir were studied, and the pressure relief gas was proposed. The method of discriminating the location of the reservoir area, and the practice of gas drainage in high-position boreholes at the test working face. The results show that: after the extra-thick coal seam is mined, the height of the overburden caving zone is 49.5 m, and the height of the fracture zone is 104 m. After the key strata in the pressure relief zone on the working face side loses stability, a pressure relief gas reservoir is formed below it. Pressure relief gas reservoir areas are divided into three categories: ①The key layer is in the bent subsidence zone, and the high-level reservoir is formed below it; ②The key layer is in the fracture zone, and the middle-level reservoir is formed under the masonry beam; ③The key layer is in the fracture zone. In the collapse zone, a low-level storage area is formed under the cantilever beam. The shape and area of ​​the reservoir are closely related to the state of the control key layer above. Before the control key layer is broken, the area continues to increase. The shape of the low-level reservoir is rectangular, and the shape of the middle and high-level reservoir is semi-elliptical, expanding to a three-dimensional shape. It is a rectangular cross-section ring body and an elliptical cross-section semi-ellipsoid body; the area decreases rapidly after breaking, and then changes periodically with the pressure of the overlying rock. The low-level reservoir is trapezoidal, the middle-level reservoir is triangular, and the high-level reservoir is shaped like a trapezoid. The shape is a semi-ellipse, and the three-dimensional shape is expanded to a rectangular cross-section ring, a triangular cross-section ring and an elliptical cross-section semi-ellipsoid. The location of the final hole of the high-level borehole was arranged in the range of the middle reservoir area, and the drainage verification was carried out. The maximum drainage concentration of a single hole was 34.5%, the average drainage concentration was 16.8%, and the upper corner gas concentration after drainage was 0.55%, The gas drainage effect is good, indicating that the arrangement of high-level drilling holes according to this method is reasonable.

Despite being the most widespread blister beetle subfamily, Nemognathinae is unfairly understudied in China. In this study, a new genus and species, Sinostenoria yangi Pan, from northern China is described and illustrated. The antennae, elytra, hind wings, and claws of the new genus form a truly unique set of characteristics never observed in other genera of Nemognathini Laporte de Castelnau, 1840. Three species from China are newly recorded and illustrated: Megatrachelus sibiricus (Tauscher, 1812), Zonitomorpha dollei (Fairmaire 1889), and Stenodera djakonovi Aksentjev, 1978. The genus Oreomeloe Tan, 1981, is transferred from the tribe Meloini Gyllenhal, 1910, to Nemognathini based on an examination of the types. Aiming to test the morphology-based placement of the new genus, we conducted molecular phylogenetic analyses using two mitochondrial (COI, 16S) and three nuclear markers (28S, CAD, ITS2). The results confirm our tribal assignment of the new genus and support a clade that consists of Sinostenoriagen. n., Longizonitis Pan and Bologna, 2018, Stenoria cf. grandiceps, and Ctenopus cf. persicus.

BackgroundTraditional text-based system engineering in the design and application of passive residual heat removal systems (PRHRS) for lead-cooled fast reactors has several requirement problems, such as low development efficiency, a long iteration cycle, and model ambiguity.PurposeThis study aims to effectively address the aforementioned problems encountered in the PRHRS of lead-cooled fast reactors by adopting a model-based system engineering method.MethodsThe model-based system engineering (MBSE) method was preliminarily applied to the design requirement analysis of a PRHRS for lead-cooled fast reactors. During the design requirements study, the design process was combined with the preliminary design of the system architecture, comprising three parts: requirements analysis, functional analysis, and design synthesis.ResultsThe generated requirement and use case diagrams describe the system requirements and determine the top-level use cases of the system in the requirement analysis stage. The time sequence, activity, and state machine diagrams form the system function model and provide early confirmation and verification in the functional analysis stage. Finally, the white box model realizes the analysis and design of the system architecture in the design synthesis stage.ConclusionsThe system architecture designed by this method ensures the consistency of the design requirements. In the future, it will further reduce the design risk, improve the design efficiency, and provide an application reference for the design and optimization of digital lead-cooled fast reactors' passive residual heat removal systems.

Cardiac hypertrophy is initially an adaptive response to physiological and pathological stimuli. Although pathological myocardial hypertrophy is the main cause of morbidity and mortality, our understanding of its mechanism is still weak. NFAT3 (nuclear factor of activated T-cell-3) is a member of the nuclear factor of the activated T cells (NFAT) family. NFAT3 plays a critical role in regulating the expression of cardiac hypertrophy genes by inducing their transcription. Recently, accumulating evidence has indicated that NFAT3 is a potent regulator of the progression of cardiac hypertrophy. This review, for the first time, summarizes the current studies on NFAT3 in cardiac hypertrophy, including the pathophysiological processes and the underlying pathological mechanism, focusing on the nuclear translocation and transcriptional function of NFAT3. This review will provide deep insight into the pathogenesis of cardiac hypertrophy and a theoretical basis for identifying new therapeutic targets in the NFAT3 network.

Cohen syndrome (OMIM No. # 216550) is a rare autosomal recessive disorder caused by homozygous mutation in the vacuolar protein sorting 13 homolog B (VPS13B) gene on chromosome 8q22.2. Clinical manifestations include hypermobile joints, microcephaly, intellectual disabilities, craniofacial and limb anomalies, and neutropenia. To date, more than 200 mutations of VPS13B have been reported in over 1,000 Cohen syndrome patients. This article reviews the clinical data of two cases of Cohen syndrome diagnosed by whole exome sequencing.

Being overweight is a risk for various chronic diseases. Alginate, a soluble dietary fiber extracted from seaweed, has been linked to weight loss with unclear mechanisms. We conducted a double-blind, randomized trial in overweight or normal-weight adults to explore alginate’s weight loss effect and mechanism. Normal-weight or overweight participants were randomized to receive either alginate (15 g/day) or maltodextrin (13.8 g/day) for 14 weeks. Compared to maltodextrin (−0.91 kg; 95% CI, −1.91 to 0.10), alginate helped overweight subjects lose weight (−2.67 kg; 95% CI, −3.89 to −1.46) (P = 0.0017) after 14 weeks. In overweight subjects, alginate increased fecal-conjugated bile acids (taurocholate acid and taurochenodeoxycholic acid) and reduced bile acid-related bacteria (Bacteroides, Oscillibacter and Eubacterium). Our results indicate that alginate decreases weight and increases bile acid excretion in overweight subjects, related to gut microbiota alterations and inhibited intestinal bile acid absorption.

Polypropylene (PP) is an environmentally friendly cable insulation material with relatively great insulation properties and has the advantages of being recyclable as a thermoplastic material. PP is easy to brittle fracture due to its poor toughness at low temperatures. Hence,it is necessary to improve the toughness of PP. In this paper,three modified PP samples are studied,namely PP blended with 10% mass fraction of polyolefin elastomer(POE),PP blended with 10% mass fraction of styrene ethylene butylene styrene (SEBS),and copolymerization modified PP specimen synthesized with PP as matrix and polyethylene (PE) in the reactor. The PP samples before and after modification are tested to obtain their physical properties,chemical properties,mechanical properties and electrical properties. It is concluded that the toughness,tensile strength and elongation at break of PP increase after the modification,while the melting temperature decreases and the dielectric loss increases. For the modification methods,the initial melting temperature and AC breakdown field strength at 20-80 ℃ of the copolymerization modified PP specimen are higher than those of the blending modified PP specimens. Instead,the blending modified PP specimens have better mechanical properties and lower dielectric loss at high temperature than the copolymerization modified PP specimen does. After comprehensive consideration,the copolymerization modification may be more suitable to enhance the toughness of PP than the blending modification.

Background/Aim. Staphylococcus aureus (S. aureus) is a gram-positive pathogen that causes various human diseases. S. aureus causes pneumonia, which is characterized by localized tissue necrosis. The aim of the study was to explore the expression of mouse β-defensin 3 (mBD-3) induced by S. aureus in mouse lungs and the effect of mBD-3 expression on the mitogen-activated protein kinase (MAPK) pathway. Methods. An experimental model of S. aureus pneumonia in mice was developed, and the expression of mBD-3 and activation of the MAPK pathway were investigated using the methods of immunofluorescence and western blot. Results. The experimental model was created successfully. The number of white blood cells was elevated 48 and 72 hrs after the introduction of bacteria through mouse airways, and bronchiolar mucosal hyperemia was observed, along with a large number of white blood cells and mucus in the bronchioles. The mBD-3 expression levels 48 and 72 hrs after the induction of infection were greater than the levels in the control group and 24 hrs after the induction. The amount of phosphorylated extracellular signal-regulated kinase (ERK1/2) was increased 48 and 72 hrs after infection induction, compared with the levels in the control group and 24 hrs after induction. The expression of mBD-3 was lower when ERK1/2 phosphorylation was inhibited by the U0126 inhibitor. Conclusion. S. aureus in experimental pneumonia mouse model accelerates mBD-3 expression in the mouse lung mainly through an ERK1/2-dependent signaling pathway.

Zhiyu Li,1 Pu Zhao,2 Qing Xu,3 Jianhai Bi,1,4,5,&ast; Ran Huo1,4,5,&ast; 1Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People’s Republic of China; 2Department of Plastic Surgery, Liaocheng Hospital of Traditional Chinese Medicine, Liaocheng, People’s Republic of China; 3Department of Plastic and Aesthetic Surgery, Maternity and Child Health Care of Zaozhuang, Zaozhuang, People’s Republic of China; 4Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China; 5Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jianhai Bi; Ran Huo, Email bijianhai@126.com; huoran@medmail.com.cnAbstract: The incidence of adverse events after hyaluronic acid filling is gradually increasing. In addition to acute reactions in the early postoperative period, there have been some cases of delayed inflammatory reactions. However, such events are rarely reported in Asia, which may be due to atypical symptoms, long intervals, and misidentification of the product quality. Herein, we present a case in which erythema of the neck appeared three weeks after hyaluronic acid injection into the neck lines and a delayed inflammatory reaction was diagnosed. Watchful waiting was performed, and the erythema subsided spontaneously after two weeks. This case suggests that in patients with a history of hyaluronic acid injections who develop allergic and inflammatory reactions after an interval, it is important to consider whether the reaction is a delayed inflammatory reaction, and if aggressive intervention is necessary.Keywords: delayed inflammatory reactions, hyaluronic acid, neck lines, root canal, COVID-19 vaccination

Idioms are highly conventionalized expressions that allow users to express beyond literal meanings. Despite the language difference, counterparts of idioms may overlap cross-culturally due to similar origin, social habits, and experiences. It is therefore interesting to probe whether L2 learners may benefit from deliberate instructions built on shared counterparts existing in both L1 and L2, known as cross-language overlaps. Although the phenomenon of cross-language overlap has been reported by lexical and collocation processing research (e.g., Carrol & Conklin, 2017; Hubers et al., 2020), it is yet uncertain whether its impact is influential for L2 idiom learning with the absence of semantic or syntactical similarity. To address this gap, the current study attempted to investigate whether raising English as a foreign language learners' awareness of cross-language overlap may facilitate L2 idiom teaching and how such overlap-enhancement instruction may change over different congruence conditions (congruence-available and incongruence conditions) and time. The study collected L2 idiom learning data from forty-five Chinese English learners, following a pretest-posttest design. While the experimental group (n=26) learned twenty-eight target L2 idioms with an enhancement instruction emphasizing the overlaps, the control group (n=28) learned these idioms with a conventional instruction method. Findings of this study revealed that participants were able to benefit from cross-language overlaps from both conditions, and the enhancement instruction on the semantic overlaps would result in significant learning improvement. It is therefore pedagogically advisable for language teachers to marry up L1-L2 idiom phrases containing similar counterparts and deliberately focus on the semantic congruency.