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In this paper, a method for determining the optimal height with the objective of decreasing the error in low-activity gamma measurements of different samples is combined with the use of liquid standards to measure the efficiency of semiconductor detectors. The procedure was applied to find the optimal height of measurement in the 1,460 MeV line of K40 in zeolites. [ABSTRACT FROM AUTHOR]

Introducción. El síndrome alcohol fetal (SAF) es un conjunto de defectos congénitos causados por el consumo materno de alcohol durante el embarazo y se caracteriza por crecimiento deficiente, disfunción del sistema nervioso central (SNC) y un conjunto de anomalías faciales menores. El término de efectos fetales del alcohol (EFA) se usa para individuos con exposición prenatal a alcohol (EPA), con algunas características del SAF, pero no todas. Objetivo. Debido al subdiagnóstico observado para los EFA o incluso del SAF, en el presente trabajo se valoró antropométricamente una población de recién nacidos (RN) con EPA y se evaluó su utilidad para la identificación de RN con EFA o SAF. Material y métodos. Estudio de corte transversal basado en una población hospitalaria. Se aplicó el cuestionario AUDIT-C a alrededor de 1000 madres en el puerperio inmediato para definir la presencia de EPA (puntaje AUDIT-C >7). Encontramos 34 RN con EPA, de los cuales 14 se diagnosticaron con EFA por presentar además alguno de los criterios diagnósticos de SAF del CDC: dismorfia facial, retardo del crecimiento prenatal o afección del SNC. De los RN sin EPA (puntaje de AUDIT-C de 0-3) se seleccionaron al azar 197 como grupo control. En ambos grupos se realizó una evaluación antropométrica. Las variables cuantitativas fueron contrastadas con la prueba t de Student con nivel de significancia de P menor a 0.05. Resultados. Durante el período de estudio no se encontró ningún RN con SAF. De los parámetros evaluados, los RN con EFA mostraron retardo del crecimiento (peso y talla

Abstract: Mammary Paget disease is a rare form of breast cancer, which typically presents as an eczematous plaque on the nipple or surrounding skin. It is often a clinical diagnosis that is confirmed with skin biopsy. Histologic hallmarks of mammary Paget disease include large, pleomorphic, malignant, ductal epithelial cells within the epidermis. Chronic lichenoid inflammation may be seen in the papillary dermis but is not diagnostic. Because mammary Paget disease often overlies ductal carcinoma in situ or invasive carcinoma of the breast, prompt bilateral mammography is warranted. We report a case of Paget disease of the nipple with negative breast imaging that was originally misdiagnosed due to a dense lichenoid infiltrate obscuring the neoplasm., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Objective: Evaluation of viscoelastic parameters along with Hct percentages, platelet numbers, and fibrinogen concentrations in healthy dogs undergoing elective stifle arthroscopy and tibial plateau leveling osteotomy (TPLO). These results determine if dogs are in a normal, hypocoagulable, or hypercoagulable state at 4 different time points., Animals: Prospective study of 37 client-owned dogs enrolled between February 2, 2022, and November 10, 2022., Methods: All dogs received a standardized anesthetic protocol. Patients enrolled in the study underwent stifle arthroscopy using a 3-portal technique with a TPLO performed by board-certified surgeons. Viscoelastic testing, Hct percentage, fibrinogen concentration, and platelet numbers were measured preoperatively, immediately postoperatively, 24 hours postoperatively, and 14 days postoperatively., Results: Stifle arthroscopy and TPLO surgery was not associated with significant effects on viscoelastic coagulation monitoring and fibrinogen concentrations in healthy dogs when comparing the time points., Clinical Relevance: Humans have a high risk of thrombotic events when undergoing elective orthopedic surgery and are often placed on prophylactic antithrombotic medication prior to surgery. Viscoelastic coagulation monitoring in dogs undergoing similar orthopedic procedures has been evaluated in veterinary medicine, but the effects on platelets and fibrinogen concentrations from similar orthopedic procedures and uniform anesthesia protocols have not been documented. Cranial cruciate ligament insufficiency is the most common orthopedic injury in dogs. Treatment requires elective surgical correction for the best results and improved long-term prognosis. The findings of this study suggest that similar preoperative prophylactic antithrombotic intervention is not needed for canine patients.

Diabetic chronic ulcers are plagued with persistent nonresolving inflammation. However, diabetic wound environment early after injury suffers from inadequate inflammatory responses due to reductions in proinflammatory cytokines levels. Diabetic neutrophils have known impairments in bactericidal functions. We hypothesized that reduced bacterial killing by diabetic neutrophils, due to their bactericidal functional impairments, results in reduced bioactive bacterial products, known as pathogen-associated molecular patterns, which in turn contribute to reduced signaling through toll-like receptors, leading to inadequate production of proinflammatory cytokines in infected diabetic wound early after injury. We tested our hypothesis in db/db type 2 obese diabetic mouse wound infection model with Pseudomonas aeruginosa. Our data indicate that despite substantially higher levels of infection, toll-like receptor 4-mediated signaling is reduced in diabetic wounds early after injury owing to reduced bioactive levels of lipopolysaccharide. We further demonstrate that topical treatment with lipopolysaccharide enhances toll-like receptor 4 signaling, increases proinflammatory cytokine production, restores leukocyte trafficking, reduces infection burden, and stimulates healing in diabetic wounds. We posit that lipopolysaccharide may be a viable therapeutic option for the treatment of diabetic foot ulcers if it is applied topically after the surgical debridement process, which is intended to reset chronic ulcers into acute fresh wounds., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

Background: Hypereosinophilic syndrome (HES) encompasses a group of diseases with blood hypereosinophilia and eosinophil-mediated organ dysfunction. HES-associated skin abnormalities, termed cutaneous HES (cHES) here, may influence diagnosis of HES. We sought to better define clinical and histopathological features of cHES., Methods: We retrospectively reviewed clinical records and cutaneous histopathology of adult patients with HES evaluated at our institution from 2007 to 2018., Results: Forty-one percent (61/150) patients with HES had cHES. The most common clinical morphologies were urticarial (30%) and eczematous (26%). Skin specimens most often showed a spongiotic pattern (31%) with abundant inflammation (50%) including eosinophils (85%). Two specimens (8%) showed interstitial granulomatous dermatitis, and two specimens showed eosinophilic fasciitis (8%). Vasculitis was not identified in any specimen. Eighty-four percent of patients with cHES had ≥1 other organ system involved: pulmonary 41%, ENT 26%, and nervous 23%. Sixty percent (53/89) of non-cHES patients had at least two organ systems involved. Cardiac or gastrointestinal involvement was more common in non-cHES than cHES (p < 0.05)., Conclusion: Our review confirms that there are no specific clinical or histopathological cHES patterns, but HES should be considered in patients who have eczematous or urticarial reactions of unknown etiology and persistent peripheral hypereosinophilia., (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)