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To prospectively evaluate the effect of benzalkonium chloride (BAK)-preserved latanoprost on ocular surface damage and identify the associated risk factors among treatment-naive glaucoma patients. The basal Schirmer’s test results, corneal Oxford staining score, non-invasive keratograph tear-breakup time, oculus hyperemia index score (objective metrics), and ocular surface disease index (OSDI) questionnaire (subjective metric) were evaluated at baseline, 1 month, and 4 months after receiving latanoprost eye drops. Associated risk factors were assessed by multivariate linear regression. Seventy-four eyes (44 patients) were enrolled. Basal Schirmer’s test tear-flow and Oxford scores gradually deteriorated (β = −0.14, P = 0.001 and β = 0.1, P < 0.001, respectively). The percentage of unstable tear-film (breakup time < 10 s) increased significantly at 4 months (6.21% vs 9.11%, P = 0.042). Hyperemic scores increased significantly at 1 month and normalized at 4 months (P = 0.01 and P = 0.16, respectively); total OSDI scores tended to improve (β = −0.76, P = 0.06). Older age was associated with additional corneal Oxford staining (P = 0.005); female sex was associated with increased unstable tear-film scores (P = 0.01). Artificial tear use was associated with a smaller decrease in basal Schirmer’s test values (P = 0.01) and a smaller increase in unstable tear-film scores (P = 0.02). Preserved latanoprost eye drops affected ocular surface changes in glaucoma patients through decreased basal tear secretion. Artificial tears represent an early intervention in vulnerable glaucoma patients with reduced tear secretion and impaired tear-film stability.

Background Cataract surgery in combination with or after trabeculectomy is often required for improving vision in glaucoma patients. Intraocular pressure (IOP) changes may influence refractive outcomes after cataract surgery. We compared refractive outcomes of the combined and sequential approaches in managing glaucoma and cataract. Methods This retrospective case–control study included 52 patients (57 eyes) who underwent phacotrabeculectomy (combined group) and 39 patients (42 eyes) who underwent phacoemulsification at least three months post-trabeculectomy (sequential group). The IOP and refraction prediction error were compared at three months after cataract surgery. Univariate regression analyses were used to assess risk factors for the postoperative refraction prediction error. Results Anti-glaucomatous medications were not administered to either group. The mean postoperative IOP (12.96 vs. 13.80 mmHg; P = .392), refraction prediction error (−0.32 ± 1.53 vs. −0.47 ± 1.14 D, P = .594), mean absolute error (1.02 ± 1.18 vs. 0.8 ± 0.93 D, P = .320), and surgically induced astigmatism (1.85 ± 1.40 vs. 2.16 ± 1.16 D, P = .161) did not differ significantly between the combined and sequential groups. In the sequential group, the refraction prediction error correlated to the IOP change, with a 1-mm Hg rise resulting in a −0.07-diopter shift between the expected and observed refraction (r = −0.380, R2 = 0.144, P = .013); no such correlation was observed in the combined group. Conclusion Both approaches resulted in similar effective IOP control and accurate intraocular lens predictability. The IOP change affected the postoperative refraction prediction error only in the sequential approach.

BACKGROUND Healthcare and wellbeing are two main interconnected application areas of conversational agents (CAs). There is a significant increase in research, development, and commercial implementations in this area. In parallel to the increasing interest, new challenges in designing and evaluating CAs have emerged. OBJECTIVE This study aims to identify key design, development, and evaluation challenges of CAs in healthcare and wellbeing research. The focus is on the very recent projects with their emerging challenges. METHODS A review study was conducted with 17 invited studies, most of which were presented at the ACM CHI2020 conference workshop on CAs for health and wellbeing. Eligibility criteria required the studies to involve a CA applied to a health or wellbeing project in an ongoing or recently finished project. The participating studies were asked to report on their projects' design and evaluation challenges. We used thematic analysis to review the studies. RESULTS The findings include a range of topics from primary care to caring for older adults to health coaching. We identified four major themes: i) domain information and integration, ii) user-system interaction and partnership, iii) evaluation, and iv) conversational competence. CONCLUSIONS While some challenges are shared with other CA application areas, safety and privacy remain the major challenges in the healthcare and wellbeing domains. An increased level of collaboration across different institutions and entities may be a promising direction to address some of the major challenges which otherwise would be too complex to be addressed by the projects with their limited scope and budget.

Chatbots are becoming increasingly popular. One promising application for chatbots is to elicit people's self-disclosure of their personal experiences, thoughts, and feelings. As receiving one's deep self-disclosure is critical for mental health professionals to understand people's mental status, chatbots show great potential in the mental health domain. However, there is a lack of research addressing if and how people self-disclose sensitive topics to a real mental health professional (MHP) through a chatbot. In this work, we designed, implemented and evaluated a chatbot that offered three chatting styles; we also conducted a study with 47 participants who were randomly assigned into three groups where each group experienced the chatbot's self-disclosure at varying levels respectively. After using the chatbot for a few weeks, participants were introduced to a MHP and were asked if they would like to share their self-disclosed content with the MHP. If they chose to share, the participants had the option of changing (adding, deleting, and editing) the content they self-disclosed to the chatbot. Comparing participants' self-disclosure data the week before and the week after sharing with the MHP, our results showed that, within each group, the depth of participants' self-disclosure to the chatbot remained after sharing with the MHP; participants exhibited deeper self-disclosure to the MHP through a more self-disclosing chatbot; further, through conversation log analysis, we found that some participants made different edits on their self-disclosed content before sharing it with the MHP. Participants' interview and survey feedback suggested an interaction between participants' trust in the chatbot and their trust in the MHP, which further explained participants' self-disclosure behavior.

Diagnosis of the Human Immunodeficiency Virus (HIV) remains challenging due to non-specific clinical presentations and mostly flu-like symptoms, e.g., fever, headache, sore throat, and general weakness. Oral lesions, such as oral candidiasis and Kaposi sarcoma, are also frequently associated with HIV infection, whereas laryngeal manifestations are rare. We report two cases of newly diagnosed HIV patients with clinical presentations of sore throat, and endoscopy revealed an epiglottic ulcerative tumor-like lesion. A laryngomicrosurgical biopsy of the lesions was performed for persistent symptoms and suspicion of malignancy. The result revealed acute and chronic inflammation without a conclusive pathology diagnosis. Further laboratory analysis was arranged in consideration of autoimmune diseases, Epstein–Barr virus (EBV), and HIV infection due to their persistent and atypical symptoms. The results were positive for HIV infection. These patients were treated successfully with antiviral treatment and the laryngeal symptoms improved within weeks. In patients with idiopathic and persistent epiglottitis or an epiglottic ulcer after medical treatment, HIV infection needs to be considered as a potential etiology in order to institute proper treatment.

Oral cavity squamous cell carcinoma (OSCC) is a leading cause of death in Taiwan. Most of the patients in the literature are male. The risk factors, cancer characteristics, and treatment outcomes were investigated in female patients and compared with male patients in this study. This retrospective study recruited 2046 OSCC patients between 1995 and 2019. The age, tumor subsites, and survival were reviewed and recorded. Overall survival and disease-free survival were the main outcomes. Female patients represented 6.7% of the entire study cohort. Females were diagnosed at an older age and an earlier local stage than male patients (P

The analysis of surface antigens on cells, especially red blood cells (RBCs), has attracted increasing attention due to the recognition of antigenic variation that can facilitate early diagnoses. This paper presents an alternative methodology to estimate the variation of surface antigen expressions using an optical cell-detachment technique to validate the binding of individual RBCs stuck on corresponding antibody-coated surfaces. The detachment tests were implemented by an optical tweezers with gradually decreasing laser powers associated with serial antibody dilutions. Then, the antigen expression variation was estimated based on the known antibody dilution folds. The B- and B3-types of RBCs were selected for the demonstration subjects. With the semi-quantitative analysis, the proposed methodology was successfully verified for evaluating the variation of the RBC surface antigen expressions. The analysis result shows good consistency with the literature’s findings.

Live streaming is an emergent social medium that allows remote interaction between the streamer and an audience of any size. Major live-streaming platforms in some Asian countries have a digital gift-giving feature that allows viewers to directly reward streamers during live sessions. Streamers can later exchange the digital gifts they have received for money, and this monetary incentive appears likely to influence how they interact with their viewers and generate live-streaming content. However, the precise nature and mechanisms of such impact have not previously been explored. Therefore, this qualitative study with 13 streamer participants examines how digital gifting influences streamers' motivations and the nature of both the content that they generate and their social interactions with their audiences. It reports that the digital-gifting function serves as a major incentive for active streaming, but may also disincentivize some streamers from continuing to contribute, for reasons that will be explored. Moreover, the participants devised strategies for both content generation and social interaction with the specific objective of earning gifts from viewers: practices that, in some cases, appeared to limit the quality of their live-streaming content. It was also noted that the streamers tended to have constrained social relationships with their viewers, in part because such relationships were seen as unequal or one-sided due to gift-giving behavior. The paper concludes with a discussion of design considerations for the incorporation of gift-giving features into live-streaming platforms, and additional recommendations for future research and the design of such platforms.

Persistent chronic liver diseases increase the scar formation and extracellular matrix accumulation that further progress to liver fibrosis and cirrhosis. Nevertheless, there is no antifibrotic therapy to date. The ketogenic diet is composed of high fat, moderate to low-protein, and very low carbohydrate content. It is mainly used in epilepsy and Alzheimer’s disease. However, the effects of the ketogenic diet on liver fibrosis remains unknown. Through ketogenic diet consumption, β-hydroxybutyrate (bHB) and acetoacetate (AcAc) are two ketone bodies that are mainly produced in the liver. It is reported that bHB and AcAc treatment decreases cancer cell proliferation and promotes apoptosis. However, the influence of bHB and AcAc in hepatic stellate cell (HSC) activation and liver fibrosis are still unclear. Therefore, this study aimed to investigate the effect of the ketogenic diet and ketone bodies in affecting liver fibrosis progression. Our study revealed that feeding a high-fat ketogenic diet increased cholesterol accumulation in the liver, which further enhanced the carbon tetrachloride (CCl4)- and thioacetamide (TAA)-induced liver fibrosis. In addition, more severe liver inflammation and the loss of hepatic antioxidant and detoxification ability were also found in ketogenic diet-fed fibrotic mouse groups. However, the treatment with ketone bodies (bHB and AcAc) did not suppress transforming growth factor-β (TGF-β)-induced HSC activation, platelet-derived growth factor (PDGF)-BB-triggered proliferation, and the severity of CCl4-induced liver fibrosis in mice. In conclusion, our study demonstrated that feeding a high-fat ketogenic diet may trigger severe steatohepatitis and thereby promote liver fibrosis progression. Since a different ketogenic diet composition may exert different metabolic effects, more evidence is necessary to clarify the effects of a ketogenic diet on disease treatment.

The quantitative analysis of surface antigens on cells, especially red blood cells (RBCs), has attracted increasing attention due to the recognition of antigenic changes that can facilitate early diagnoses. This paper presents an alternative methodology developed using the optical cell-detachment technique to evaluate antibody-antigen interactions and quantitatively analyze the RBC surface antigen expression. RBC subtyping was used to verify the proposed detection principle based on a comparison of the bonding strengths between individual RBCs and antibody coatings. The bonding strengths were measured with serial antibody dilutions with gradually decreasing laser powers, for which a single cell was optically detached from the corresponding antibody-coated surface. With the quantitatively analysis, the proposed alternative methodology was verified as a highly sensitive technique for detecting antigen expression on the RBC surface.

Background/purpose Limited data are available on the role of illicit non-injecting drug use in a prolonged HIV outbreak that predominantly affected men who have sex with men (MSM) in Taiwan since 2006. We aimed to assess associations between specific types of drug use and incident HIV infections in this outbreak. Methods We conducted a retrospective case–control study among MSM clients at voluntary counselling and testing (VCT) service at National Taiwan University Hospital (Taipei, Taiwan). We used BED IgG-capture enzyme immunoassay to identify incident HIV infection (cases), individually matched to HIV-negative MSM clients (controls) by HIV testing date. We used a structured questionnaire to obtain the information on illicit drug use and sexual risk behaviors. Results From a total of 15,305 MSM client visits during 2006–2015, 387 cases were matched to 1012 controls. Use of inhaled nitrites (adjusted odds ratio [aOR] 2.1), MDMA (aOR 2.9), amphetamines (aOR 1.6), and ketamine (aOR 1.5) were independently associated with incident HIV infection. Polydrug (≥2 drugs) use was associated with the highest risk (aOR 4.3; 95% CI 2.6–7.2). While the proportion of MSM VCT clients who reported use of any recreational drug remained stable during 2006–2015 (average: 9.7%, P: 0.38), there was a shift in specific types of drug use, from MDMA/ketamine to inhaled nitrites/amphetamine, after 2011 (all Ps Conclusion Non-opioid recreational drugs use is associated with incident HIV infection in this prolonged HIV outbreak. There is an urgent need to formulate an effective public health response to mitigate the risk.

To prospectively evaluate the effect of benzalkonium chloride (BAK)-preserved latanoprost on ocular surface damage and identify the associated risk factors among treatment-naive glaucoma patients.The basal Schirmer's test results, corneal Oxford staining score, non-invasive keratograph tear-breakup time, oculus hyperemia index score (objective metrics), and ocular surface disease index (OSDI) questionnaire (subjective metric) were evaluated at baseline, 1 month, and 4 months after receiving latanoprost eye drops. Associated risk factors were assessed by multivariate linear regression.Seventy-four eyes (44 patients) were enrolled. Basal Schirmer's test tear-flow and Oxford scores gradually deteriorated (β = -0.14, P = 0.001 and β = 0.1, P0.001, respectively). The percentage of unstable tear-film (breakup time10 s) increased significantly at 4 months (6.21% vs 9.11%, P = 0.042). Hyperemic scores increased significantly at 1 month and normalized at 4 months (P = 0.01 and P = 0.16, respectively); total OSDI scores tended to improve (β = -0.76, P = 0.06). Older age was associated with additional corneal Oxford staining (P = 0.005); female sex was associated with increased unstable tear-film scores (P = 0.01). Artificial tear use was associated with a smaller decrease in basal Schirmer's test values (P = 0.01) and a smaller increase in unstable tear-film scores (P = 0.02).Preserved latanoprost eye drops affected ocular surface changes in glaucoma patients through decreased basal tear secretion. Artificial tears represent an early intervention in vulnerable glaucoma patients with reduced tear secretion and impaired tear-film stability.

Chatbots (conversational agents) are increasingly receiving attention in mental health domains because they elicit honest self-disclosure about personal experiences and emotions. Although such self-disclosure contents can be useful for gauging mental status, little research has addressed how to automatically assess mental status from self-disclosures to a chatbot. If a chatbot can automatically assess the mental status of users, it can help them improve their mental wellness or facilitate access to mental professionals. In this paper, we examine whether indicators that identify depression from written texts (e.g., social media posts) are also useful for assessing mental status from disclosures to a chatbot. We first ran a study with 30 participants who engaged in daily journaling with a chatbot that prompted them to record their moods and experiences for three weeks. We then divided the participants' self-disclosure data into three groups based on their mental state changes before and after the study: improved vs. deteriorated vs. no change. Comparing the data among the three groups, participants whose mental states deteriorated during the study gradually used fewer positive emotion and concrete words but more negative emotion words when describing their daily experiences and feelings to the chatbot.

Our goal was to investigate the changes in artificial short-linear chromosome average copy numbers per cell arising from partial or full loss of Mitotic Arrest-Deficient 2 (MAD2) spindle checkpoint function in budding yeast Saccharomyces cerevisiae. Average artificial linear chromosome copy numbers in a population of cells, as measured by quantitative polymerase chain reactions (qPCR), and retention rates, as measured by fluctuation analyses, were performed on a total of 62 individual wild type and mad2∆ mutant haploid and diploid clones. Wild type cells, both haploids and diploids, displayed phenotypically unique clone-to-clone differences: one group of 15 clones displayed low-copy numbers per cell and high retention rates, were 1 clone was found to have undergone a genomic integration event, and the second group of 15 clones displayed high copy numbers per cell and low retention rates, with the latter values being consistent with the previously published results where only a single clone had been measured. These chromosome states were observed to be unstable when propagated for 10 days under selection, where high copy-low retention rate clones evolved into low copy-high retention rate clones, but no evidence for integration events was observed. By contrast, mad2∆ haploid and mad2∆/mad2∆ diploids displayed a suppression of the clone-to-clone differences, where 20 out of 21 clones had mid-level artificial linear chromosome copy numbers per cell, but maintained elevated chromosome retention rates. The elevated levels in retention rates in mad2∆ and mad2∆/mad2∆ cells were also maintained even in the absence of selection during growth over 3 days. MAD2/mad2∆ heterozygous diploids displayed multiple clonal groups: 4 with low copy numbers, 5 with mid-level copy numbers, and 1 with a high copy number of artificial linear chromosomes, but all 10 clones uniformly displayed low retention rates. Our observations reveal that MAD2 function contributes to the ability of yeast cells to maintain a high number of artificial linear chromosomes per cell in some clones, but, counter-intuitively, mad2∆ suppresses clone-to-clone differences and leads to an improvement in artificial linear chromosome retention rates yielding a more uniform and stable clonal population with mid-level chromosome copy numbers per cell.

Objectives: Oral cavity squamous cell carcinoma (OSCC) is a leading cause of death in Taiwan, and most of the patients are male. Little is known about the differences in risk factors, cancer characteristics and treatment outcomes in female patients. The study aim is to investigate the clinicopathological and outcome differences between gender in patients affected by oral cancer in Taiwan.Methods: This is a retrospective study based on data obtained between 1995 and 2019. A total of 2,046 patients were recruited for analysis. Cancer characteristics, risk factors and treatment outcomes in patients with oral cancer between genders were collected. Results: Female patients represented the 6.7% of the entire cohort of study. Females were diagnosed at an older age and at an earlier local stage compared to male patients (p < 0.001). The female patients were less exposed to cigarette, alcohol, and betel-nut (BQ) (all p-values < 0.001). Tongue (55.1%) was the most frequent subsite involved in the female group, while buccal (38.4%) and tongue (35.3%) were more likely (p < 0.001) to be associated with male gender. In tongue cancer subgroup, female patients presented less frequently extra-nodal extension compared with male patients (p = 0.040). During the follow-up period, there was no significant difference in recurrence and overall deaths between genders.Conclusion:In Taiwan, the male to female ratio in OSCC is 14:1. The tumor subsite distribution, environment exposure and stage distribution are different between females and male. There are no differences in term of survival between female and male OSCC patients.

Objectives Real-world experience regarding the effectiveness of co-formulated elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide (EVG/C/FTC/TAF) as a switch regimen is sparse among people living with HIV (PLWH) harbouring the M184V/I mutation with or without thymidine analogue-associated mutations (TAMs). Methods In this retrospective multicentre study, PLWH who were switched to EVG/C/FTC/TAF after having achieved viral suppression (plasma HIV RNA Results Overall, 100 case patients with the M184V/I mutation were identified, including 6 (6.0%) with K65R and 13 (13.0%) with at least one TAM, and were matched to 400 controls in terms of gender, age (mean = 40.3 versus 39.7 years) and cumulative exposure duration to tenofovir disoproxil fumarate (median = 146 versus 143 weeks). At Week 48, the rate of virological non-success for the case patients and controls was 5.0% (5/100) and 3.3% (13/400), respectively (difference = 1.7%; 95% CI = −2.9%–6.3%), while the rate of virological success was 88.0% and 89.5% for the case patients and controls, respectively. The presence of the K65R mutation or TAMs was not associated with virological non-response. Conclusions Among virally suppressed PLWH, EVG/C/FTC/TAF is effective in maintaining viral suppression at Week 48 despite archived M184V/I mutation with or without TAMs.

Chatbots have great potential to serve as a low-cost, effective tool to support people's self-disclosure. Prior work has shown that reciprocity occurs in human-machine dialog; however, whether reciprocity can be leveraged to promote and sustain deep self-disclosure over time has not been systematically studied. In this work, we design, implement and evaluate a chatbot that has self-disclosure features when it performs small talk with people. We ran a study with 47 participants and divided them into three groups to use different chatting styles of the chatbot for three weeks. We found that chatbot self-disclosure had a reciprocal effect on promoting deeper participant self-disclosure that lasted over the study period, in which the other chat styles without self-disclosure features failed to deliver. Chatbot self-disclosure also had a positive effect on improving participants' perceived intimacy and enjoyment over the study period. Finally, we reflect on the design implications of chatbots where deep self-disclosure is needed over time.

Digital gifting in live streaming, in which viewers buy digital gifts to reward the streamers, was worth over $200 million in 2018 in China and its growth has been accelerating. This paper explores what motivates people to tip and how it impacts interactions between viewers and streamers. Through a survey, we identified the main categories of viewers' tipping motivations. We found that viewers were motivated by the reciprocal acts of streamers, who would engage in various types of social interactions with tippers during the live streams. The styles of interactions and contents of live stream based on the tipping are differently influenced by the motivations of viewers and streamers. For example, viewers often tip large to attract attentions from the crowd or promote preferred live-streaming content. These findings provide more knowledge on the social interaction in live streaming platforms.

Attention detection is important for many applications. Automatic determination of users' visual attention state is challenging because attention involves numerous complex and internal human cognitive functions. Behavioral observations, such as eye gaze or response to external stimuli, can provide clues for users' visual attention state; however, users' cognitive state cannot be easily known. Conventional electroencephalography-based methods detect attention by observing the dynamic changes in the frontal lobe of the brain, especially in the anterior cingulate cortex (ACC). However, that area in the brain is associated with many functions, some of which correlate with conscious experience but are not directly related to attention. In this paper, we design an attention monitoring system to detect whether the brain experiences a visual stimulus consciously. Our experiments verified the feasibility of our design, and the average classification rate ranged from 72% to 82%.

Over the years, it was getting attention to hepatitis C virus (HCV) and human immu-nodeficiency virus (HIV) infection among injected drug users (IDUs) in Taiwan. This study investigated the frequency of risky behaviors for HCV carriers and IDUs who were HIV carriers in methadone maintenance treatment program. The subjects, intravenously injected heroin abusers, were collected from a special methadone maintenance treatment clinic. The survey included characteristics of participants, sexual activity and attitude towards condom usage. The total number of subjects was 151. Data were analyzed using the statistical package SPSS 15.0. The analytical methods included descriptive analysis, Fisher’s exact test, and the logistic regression model. The study showed that 82% of intravenously injected heroin abusers were hepatitis C virus (HCV)-positive, and 44.4% were hepatitis B virus (HBV)-positive; 89.5% of HIV-positive heroin abusers were type C hepatitis positive. Only 21.2% of these intra-venously injected heroin abusers always used a condom, and 39.7% never used a condom during sexual activity. Logistic regression analysis showed smoking, sharing syringes needles, HBV status and condom use status were four main risk factors on HIV infection. Sharing or using contaminated syringes needles was the main cause of HIV, HBV, and HCV infection in the drug addiction group. Since our government has the policy of providing a methadone maintenance treatment program, the spread of HIV is under control, but knowledge about HIV and safe sex education still needs improvement.

Live streaming is a proliferating social media generating special social interactions on the platforms especially in China. For example, tipping in live streaming, in which viewers buy virtual gifts to reward the streamers. This paper explores people's tipping behaviors and how it impacts interactions between viewers and streamers. We analyzed 12 videos of live streams by labeling the viewer-streamer interactions, and found that viewers were motivated by the reciprocal acts of streamers. Furthermore, we interviewed 5 streamers to understand their motivations behind the viewer-streamer interactions. Our future study would investigate tipping motivations from the viewers' perspective.

On existing crowdfunding platforms, the allocation of money is often not regulated, which leads to less-than-ideal distribution of resources. For example, recent donations to hurricane victims through their crowdfunding campaigns often lead to overfunding of certain victims while underfunding others. Inspired by algorithms from economic theories, we proposed a Smart Crowd Donate system encourages donors to express preferences to multiple projects and reallocates funds dynamically across these preferences over time. We conducted a user study in which recruited 452 participants to simulate a small scale of crowdfunding. The findings of our user study supported the idea that the Smart Crowd Donate system has potential to efficiently distribute funds to projects and allows more projects to receive the amount of money they need.

Health care researchers have recently developed several home-based sleep monitoring systems and mobile applications that support healthy sleep by monitoring a user’s sleep environment, activities, or sleep quality. This study describes the design and evaluation of an electrooculogram (EOG)-based system for an automatic sleep monitoring. Compared with polysomnogram or electroencephalogram recordings, EOG has the advantage of easy placement and can be operated by the users themselves. We also design an intelligent eye mask that is user friendly for measuring sleep stage and quality. Two user experiments were carried out to demonstrate that the proposed system produces valid measurements of sleep stage and sleep quality and has good usability and reliability while not disturbing sleep significantly. These findings suggest that our system can also be applied to long-term sleep monitoring or sleep environment control to improve the user’s sleep quality and make sleep more comfortable.

ObjectivesWe aimed to investigate the awareness and willingness towards pre-exposure prophylaxis (PrEP) among individuals seeking voluntary counselling and testing (VCT) for HIV in Taiwan, where PrEP is currently not reimbursed by the insurance.MethodsBetween April and October 2016, a questionnaire interview was conducted among VCT clients to inquire about the attitudes towards PrEP against HIV infection. Multivariate logistic regression analysis was performed to identify the associated factors with willingness to initiate PrEP.ResultsDuring the 6-month period, 1173 VCT clients (99.8%) completed the interviews, with 67.4% being homosexual or bisexual male. While 67.2% of the clients knew of postexposure prophylaxis, 40.2% heard of PrEP. Overall, 546 clients (46.5%) were willing to initiate PrEP and 89.5% of them would choose event-driven PrEP. In multivariate analysis, male gender (OR 1.796; 95% CI 1.165 to 2.768), full-time job (OR 1.354; 95% CI 1.052 to 1.742), one-night stand (OR 1.374; 95% CI 1.043 to 1.810), having casual sex partners within 3 months (OR 1.329; 95% CI 1.031 to 1.714), condomless anal sex (OR 1.405; 95% CI 1.122 to 1.878) and ever having chemsex or attending a drug party in the past 1 year (OR 2.571; 95% CI 1.541 to 4.287), regular screening for HIV infection (OR 1.321; 95% CI 1.021 to 1.711) and knowledge of PrEP (OR 1.504; 95% CI, 1.159 to 1.953) were associated with willingness to initiate PrEP.ConclusionsUnderstanding the willingness to initiate PrEP against HIV among the VCT clients in Taiwan, which was associated with male gender, risky sexual behaviours and awareness of PrEP, will help inform the implementation of PrEP programme.

Objectives Two nucleos(t)ide reverse-transcriptase inhibitors (NRTIs) plus 1 non-NRTI (nNRTI) remain the preferred or alternative combination antiretroviral therapy (cART) for antiretroviral-naive HIV-positive patients in Taiwan. The three most commonly used nNRTIs are nevirapine (NVP), efavirenz (EFV) and rilpivirine (RPV). This study aimed to determine the incidences of hepatotoxicity and skin rashes within 4 weeks of initiation of cART containing 1 nNRTI plus 2 NRTIs. Methods Between June, 2012 and November, 2015, all antiretroviral-naive HIV-positive adult patients initiating nNRTI-containing cART at 8 designated hospitals for HIV care were included in this retrospective observational study. According to the national HIV treatment guidelines, patients were assessed at baseline, 2 and 4 weeks of cART initiation, and subsequently every 8 to 12 weeks. Plasma HIV RNA load, CD4 cell count and aminotransferases were determined. The toxicity grading scale of the Division of AIDS (DAIDS) 2014 was used for reporting clinical and laboratory adverse events. Results During the 3.5-year study period, 2,341 patients initiated nNRTI-containing cART: NVP in 629 patients, EFV 1,363 patients, and RPV 349 patients. Rash of any grade occurred in 14.1% (n = 331) of the patients. In multiple logistic regression analysis, baseline CD4 cell counts (per 100-cell/μl increase, adjusted odds ratio [AOR], 1.125; 95% confidence interval [95% CI], 1.031-1.228) and use of NVP (AOR, 2.443; 95% CI, 1.816-3.286) (compared with efavirenz) were independently associated with the development of skin rashes. Among the 1,455 patients (62.2%) with aminotransferase data both at baseline and week 4, 72 (4.9%) developed grade 2 or greater hepatotoxicity. In multiple logistic regression analysis, presence of antibody for hepatitis C virus (HCV) (AOR, 2.865; 95% CI, 1.439-5.704) or hepatitis B surface antigen (AOR, 2.397; 95% CI, 1.150-4.997), and development of skin rashes (AOR, 2.811; 95% CI, 1.051-7.521) were independently associated with the development of hepatotoxicity. Conclusions The baseline CD4 cell counts and use of NVP were associated with increased risk of skin rashes, while hepatotoxicity was independently associated with HCV or hepatitis B virus coinfection, and development of skin rashes in antiretroviral-naive HIV-positive Taiwanese patients within 4 weeks of initiation of nNRTI-containing regimens.

Crowdfunding platforms are emerging as an important online social platform to raise capital and awareness for innovative projects. When considered as a general online social system, the goal of a crowdfunding platform is to efficiently allocate a large number of small funds to promising new projects. However, the efficiency of donation allocation and the success rate of projects can be influenced by the behavior of donors, such as how they evaluate each project and choose the projects to donate. To understand how such behavior could impact crowdfunding market, we developed an agent-based model of crowdfunding to investigate three factors, i.e., project visibility, noise of perceived project quality, and donor strategies. These factors may impact the efficiency of a crowdfunding platform.

Background Through-and-through oromandibular defects originate from surgical intervention of tumors of the oral cavity involving external skin, soft tissue, bone, and oral lining. Reconstruction of such composite defects is primarily achieved by 4 methods using distinct flaps in Chang Gung Memorial Hospital, including a single anterolateral thigh (ALT) flap, a single fibula flap, an osteomyocutaneous peroneal artery-based combined flap, and a combination of a fibular flap and an ALT flap, also known as a double flap. Methods In this retrospective study, 41 patients with through-and-through oromandibular defects reconstructed in Chang Gung Memorial Hospital Linkou branch from July 2007 to June 2009 using either of the 4 flaps were evaluated. Patients were divided into 4 groups according to the choice of flap, and their surgical outcomes, immediate and late complications, and their general condition were studied. Group 1 included 12 patients reconstructed with a single ALT flap, whereas group 2 included 15 patients using fibular flaps. Group 3 included 8 patients with osteomyocutaneous peroneal artery-based combined flaps, and group 4 included 6 patients who underwent reconstruction with double flaps. Results Among all statistical results, we found that none of the differences regarding either patient demography or surgical outcomes between groups were statistically significant, except for squamous cell carcinoma staging. Conclusions Although the results were insignificant, trends within the data could be seen that support previous notions regarding each reconstruction method. For future studies, we strongly recommend a larger sample size.

Background With the introduction of combination antiretroviral therapy (cART) that has significantly improved survival, human immunodeficiency virus (HIV)-positive patients may be potential organ donors to HIV-positive recipients in a few countries. Organ shortage remains a challenge for organ transplantation in Taiwan, where organ donation by HIV-positive patients remains prohibited by law. Methods We assessed the willingness of organ donation (should they be pronounced brain death, and the ban on HIV-positive organ donation be lifted) among HIV-positive patients who received regular HIV care at a university hospital in a cross-sectional survey between May and August 2015 with the use of an anonymous, self-administered questionnaire interview. Results Of the 1010 participants, 93.7% were receiving cART with the latest mean CD4 count and plasma HIV RNA load of 587 cells/mm3 and 2.73 log10 copies/mL, respectively. Overall, 71.9% were willing to donate organs. In multivariate analysis, factors associated with willingness to donate organs included college or graduate school diploma (odds ratio [OR] 1.571, 95% confidence interval [CI] 1.166–2.191), registered willingness in the National Health Insurance system (OR 9.430, 95% CI 1.269–70.051), and knowledge of the information on HIV-positive deceased donors (HIVDD) (OR 1.673, 95% CI 1.073–2.608). Conclusions We concluded that a significant proportion (71.9%) of HIV-positive Taiwanese patients were willing to donate their organs. The willingness was associated with a higher education level, prior registered willingness to donate organs, and awareness of HIVDD. This article is protected by copyright. All rights reserved.

Background/Purpose: To obtain current epidemiological data for better vaccination policies, this study aimed to assess the incidence and risk factors of herpes zoster in human immunodeficiency virus (HIV)-positive patients initiating combination antiretroviral therapy (cART) in Taiwan. Methods: Between June, 2012 and May, 2015, we prospectively identified zoster cases in HIV-positive patients initiating cART. Clinical information was collected on demographics, prior zoster, plasma HIV-1 RNA load (PVL), and CD4 count at baseline and during follow up. A case–control study by 1:2 matched pairs was used to identify the risk factors for zoster development. Results: During the 3-year study period, 826 patients with a mean age of 32.9 years were included, and 7.7% had prior zoster. The mean baseline CD4 count and PVL were 286 cells/μL and 4.90 log10 copies/mL, respectively. Fifty-four (6.5%) patients developed zoster after initiation of cART, with 43 episodes (79.6%) occurring within 1 year of cART initiation, which corresponded to an overall incidence rate of 3.61/100 person-years. The multivariate analysis revealed that prior zoster (adjusted odds ratio = 3.143; 95% confidence interval, 1.385–7.133) and baseline CD4 count 5 log10 copies/mL were risk factors for zoster development after cART initiation in multivariate analysis. Conclusions: Herpes zoster occurred in 6.5% of HIV-positive Taiwanese patients after initiation of cART, which was associated with prior zoster and baseline CD4 count < 200 cells/μL or baseline PVL > 5 log10 copies/mL.

Donation-based crowdfunding has the potential to democratize capital raising by soliciting donations directly from the public through the Web and social media. These crowdfunding platforms, however, often function as unregulated open markets, in which there is minimal intervention to influence donation distribution across projects. In fact, research on crowdfunding hints that donation distribution in most crowdfunding platforms are suboptimal: while the overall success rates of crowdfunding projects are often low, a significant proportion of projects receive donations way over their targets. In this paper, we propose a new donation distributing system that aim to (a) distribute donations more effectively among the projects, and (b) align the allocation of donations with the preferences of donors. An agent-based model was developed to test the proposed system. Results showed that the proposed system not only increased the overall success rates of projects, but also led to more successes for projects preferred by donors. Implications to future crowdfunding platforms are discussed.

This study investigated the correlations between consumption of antifungal agents and species distribution in candidaemia. The incidence of patients with community-acquired candidaemia (CAC) (per 1000 admissions) and healthcare-associated candidaemia (HCAC) (per 1000 admissions) as well as data on annual consumption [defined daily doses (DDD)/1000 patient-days] of various antifungal agents at a medical centre in Taiwan from 2000 to 2010 were evaluated. A total of 2682 episodes of candidaemia were identified, including 2468 HCAC (92.0%) and 214 CAC (8.0%). The most prevalent species was Candida albicans (53.3%), followed by Candida tropicalis (20.5%), Candida glabrata (15.4%), Candida parapsilosis (14.1%), Candida guilliermondii (1.7%) and Candida krusei (1.5%). The overall incidence of candidaemia remained stable, whereas that of candidaemia due to C. parapsilosis and C. guilliermondii decreased significantly with time. Significant negative correlations were found between the use of echinocandins and voriconazole and the incidence of C. parapsilosis candidaemia and between the use of caspofungin and the incidence of C. guilliermondii candidaemia. In contrast, there were significant positive correlations between the use of echinocandins and the incidence of C. tropicalis candidaemia, the use of azoles and the incidence of C. glabrata and non-albicans Candida candidaemia, and the use of itraconazole and the incidence of C. parapsilosis and C. guilliermondii candidaemia. Increased use of fluconazole was associated with an increased incidence of HCAC due to non-albicans Candida spp. In conclusion, the impact of consumption of antifungal agents on the incidence of candidaemia caused by different Candida spp. varies and warrants further studies to confirm these findings.

To investigate the clinical and microbiological characteristics of infections caused by Tsukamurella spp., the computerised database of the Bacteriology Laboratory at National Taiwan University Hospital (Taipei, Taiwan) was reviewed retrospectively to identify patients with infections caused by this species during the period January 1997 to December 2008. All of the isolates had been initially misidentified as Rhodococcus spp. Identification of Tsukamurella isolates to species level was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of the heat shock protein gene (hsp65) as well as 16S rRNA gene sequencing. During the study period, a total of eight patients with Tsukamurella infection and two patients with Tsukamurella colonisation were identified. Tsukamurella tyrosinosolvens (n=6) was the most prevalent species, followed by Tsukamurella spumae (n=3) and Tsukamurella pulmonis (n=1). Keratitis was the most common type of infection (n=3), followed by catheter-related bloodstream infection (n=2). One of the patients with Tsukamurella infection died due to bacteraemia; the other seven patients with Tsukamurella infection had favourable outcomes. The three species had different drug susceptibility patterns; T. pulmonis was the most resistant pathogen, with higher minimum inhibitory concentrations of clindamycin (>2 mg/L), erythromycin (2 mg/L) and tetracycline (8 mg/L) than those for the other Tsukamurella spp. In conclusion, strains of Tsukamurella spp., including T. spumae, are uncommon causative agents of ocular infections and bacteraemia in cancer patients. Molecular diagnostic methods are essential to distinguish species in the Tsukamurella genus from species in other phylogenetically related genera such as Rhodococcus.

Objectives: CNS infections caused by non-tuberculous mycobacteria (NTM) are rare and only three cases of CNS infections due to Mycobacterium abscessus complex have been reported. Methods: We searched the Mycobacteriology Database of the National Taiwan University Hospital and identified patients with CNS infections due to NTM. Results: A total of 15 patients, namely 4 HIV-seropositive patients and 11 HIV-seronegative patients, with CNS infections caused by NTM were identified during 2000‐10. All of the HIV-seropositive patients had disseminated Mycobacterium avium complex infections. Among the 11 HIV-seronegative patients, NTM CNS infections were due to M. abscessus complex in 8 patients, M. avium complex in 2 patients and Mycobacterium kansasii in 1 patient. All the six preserved M. abscessus complex isolates were confirmed to be Mycobacterium massiliense by erm(41) PCR and 23S rRNA gene sequence analysis. Among the eight patients with infections due to M. abscessus complex, three had otolaryngological diseases, four had received neurosurgery and one had disseminated disease. Five patients received surgical debridement or intracranial device removal and three patients died of M. abscessus complex CNS infection. Among the five patients who survived, all received clarithromycin-based combination therapy with a median duration of 12 months and four received surgical intervention. All six isolates available for drug susceptibility testing showed uniform susceptibility to clarithromycin and five were susceptible to amikacin. Conclusions: Our study revealed that M. abscessus complex isolates, particularly M. massiliense, should be considered potential pathogens causing CNS infections. Long-duration clarithromycin-based combination therapy plus surgical intervention may provide the best chance of cure.

To investigate the clinical impact of different genospecies of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex (ACB complex; A. baumannii, Acinetobacter gen. sp. 13TU and Acinetobacter gen. sp. 3) on the severity of bacteraemia.We retrospectively compared the clinical features and outcomes of patients with bacteraemia caused by A. baumannii, Acinetobacter gen. sp. 13TU or Acinetobacter gen. sp. 3. The genospecies were identified using oligonucleotide array sequence analysis (interspacer sequence), and the clonality of Acinetobacter gen. sp. 13TU and 3 isolates was determined by PFGE analysis.A total of 215 patients with bacteraemia due to ACB complex were evaluated. Among them, 117 (54.4%) had A. baumannii bacteraemia, 77 (35.8%) had Acinetobacter gen. sp. 13TU bacteraemia and 21 (9.8%) had Acinetobacter gen. sp. 3 bacteraemia. A. baumannii bacteraemia was associated with a higher 14 day mortality rate (P0.001), a higher 30 day mortality rate (P0.001) and a higher in-hospital mortality rate than bacteraemia due to Acinetobacter gen. sp. 13TU or Acinetobacter gen. sp. 3. Independent prognostic factors for the 30 day mortality included the Charlson co-morbidity index (P0.001) and Pitt bacteraemia score (P0.001). Bloodstream infection caused by a multidrug-resistant A. baumannii isolate appeared to be associated with a poor outcome (P = 0.069). There was no clonal spread of Acinetobacter gen. sp. 13TU or Acinetobacter gen. sp. 3 during the study period.Bacteraemia due to multidrug-resistant strains but not A. baumannii per se appears to be associated with poor outcome.

Objectives This study investigated the correlation between antibiotic consumption and antimicrobial resistance in Gram-negative bacteria causing healthcare-associated infections at a university hospital in Taiwan from 2000 to 2009. Methods Disc susceptibility data of Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus spp., Pseudomonas aeruginosa, Acinetobacter spp., Stenotrophomonas maltophilia and other non-fermentative Gram-negative bacilli causing healthcare-associated infections were evaluated. Data on annual patient-days and annual consumption (defined daily doses per 1000 patient-days) of extended-spectrum cephalosporins, β-lactam/β-lactamase inhibitor combinations, carbapenems, aminoglycosides and fluoroquinolones were analysed. Results The trend of total consumption of extended-spectrum cephalosporins, β-lactam/β-lactamase inhibitor combinations, carbapenems, aminoglycosides and fluoroquinolones significantly increased between 2000 and 2003 and remained stable between 2004 and 2009. The decreasing use of gentamicin and amikacin in recent years was associated with increasing susceptibility of E. coli, E. cloacae, S. marcescens and P. aeruginosa to gentamicin, as well as increasing susceptibility of P. aeruginosa to amikacin. The use of piperacillin/tazobactam was positively correlated with the prevalence of piperacillin/tazobactam-resistant E. coli and S. maltophilia. In contrast, the use of cefotaxime and piperacillin/tazobactam was negatively correlated with the prevalence of cefotaxime-resistant E. coli and piperacillin/tazobactam-resistant S. maltophilia, respectively. The consumption of fluoroquinolones was positively correlated with the rates of ciprofloxacin-resistant E. coli, piperacillin/tazobactam-resistant P. aeruginosa and ceftazidime-resistant S. maltophilia. Conclusions The relationship between antibiotic prescription and the rates of resistance for Gram-negative bacteria is complicated; every type of antimicrobial agent or even individual agent can have distinct associations with different pathogens.

The main goal of this letter is to increase the impedance bandwidth of a hybrid bow-tie antenna with end-fire radiation pattern by combining with slots and a patch radiator. The proposed antenna simplify the structure of an antenna with the merits of light weight, low cost, ease fabrication for many wireless and mobile applications. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 1905–1908, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24463

A compact internal antenna is proposed for GSM/GPS/DCS/PCS/UMTS/Bluetooth/WLAN/WiFi/WiMAX applications. The proposed antenna is comprised of a loop antenna and a monopole antenna. The antenna system shows wide multi-operation band as well as good radiation patterns and small volume. The antenna can be printed on the system circuit board of the mobile phone and short-circuited to the system ground plane to form a loop-type structure. A comparison with that of the existing antennas showed that wide impedance bandwidth of the proposed structure can be achieved without increasing the implementation complexity.

This study presents a new design of a printed antenna with simply shaped radiator element for multi-operating bands of the wireless communication systems. With a simple design configuration and slot form on a printed circuit board, the proposed antenna can be used in multiband wireless operations, covering the GSM (880-960 MHz), DCS (1710-1880 MHz), PCS (1850-1990 MHz), UMTS (1920-2170 MHz), 2.4-GHz WLAN (2400-2484 MHz), Mobile-WiMAX (IEEE 802.16e in the Taiwan: 2500-2690 MHz) and 5-GHz WLAN (5150-5350/ 5725-5825 MHz) bands. Several properties of the proposed printed antenna in multiband operation, such as impedance bandwidth, radiation pattern and measured gain are numerically and experimentally investigated.

This presents a high-impedance ground plane (HIGP) structure for bow–tie antenna in order to improve its radiation performances. The HIGP is a kind of electromagnetic bandgap (EBG) structure to decrease surface waves and to bring an improvement of side lobe level, and reduce the mutual coupling between the two antennas. As compared to proposed antenna without HIGP, the measurement results show a fairly good antenna gain and a 5–10 dB reduction in the back lobes. Several properties of the proposed antenna for WLAN operation such as impedance bandwidth, radiation pattern, and measured gain have been investigated in detail, numerically and experimentally. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 2928–2931, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23807

New design of a dipole antenna with rectangular fractal shape radiator element with two operating bands for radio frequency identification (RFID) is presented. By using fractal shape slot and metal meander patch, the proposed antenna has the wide and dual measured return loss bandwidth. Besides, the omnidirectional radiation pattern of the design antenna cover the entire frequency range including ultra high frequency (UHF, 860–960 MHz) band and microwave (2.45 GHz) band has been obtained. Several properties of the proposed antenna for dual-band operation such as impedance bandwidth, radiation pattern, and measured gain have been investigated numerically and experimentally in detail. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 1963–1966, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23512

A new design of slot antenna by CPW-fed is proposed for ultrawideband (UWB) applications. The proposed antenna consists of a CPW-fed and a pair of symmetry curved radiating slot. The designed tapered slot antenna covers the bandwidth from 3 to 20 GHz. Simulated and measured results of the new design CPW-fed UWB slot antenna show fairly good performance. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 561–564, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22197

Study of CPW-fed monopole antenna with circular and rectangular fractal shape radiator element is proposed. By using fractal slot, new design antennas have the wide measured return loss bandwidth. In addition, the omnidirectional radiation patterns of the design antennas covering the entire frequency range have been obtained. Several properties of the antennas such as impedance bandwidth, radiation patterns, and gain have been investigated numerically and experimentally in detail. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 1267–1272, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22448

Online learning is increasingly prevalent as an option for self-learning and as a resource for instructional design. Prerecorded video is currently the main medium of online education content delivery and instruction; this affords asynchronicity and flexibility, and enables the dissemination of lecture content in a distributed and scalable manner. However, the same properties may impede learners' engagement due to the lack of social interaction and peer support. In this paper, we propose a time-anchored commenting interface to allow online learners who watch the same video clips to exchange comments on them. Comments left by previous learners at specific time points of a video are displayed to new learners when they watch the same video and reach those time points. We investigated how the display of time-anchored comments (dynamic or static) and type of comments (content-related or social-oriented) influenced users' perceived engagement, perceived social interactivity, and learning outcomes. Our results show that dynamically displaying time-anchored comments can indeed enhance learners' perceived social interactivity. Moreover, the content of comments would further affect learners' intention of commenting. Based on our findings, we make various recommendations for the improvement of social interaction and learning experience in online education.

Background Nevirapine extended-release (NVP-XR) taken once daily remains an effective antiretroviral agent for patients infected with HIV-1 strains that do not harbor resistance mutations. Presence of tablet remnants of NVP XR in stools was reported in 1.19% and 3.05% of subjects in two clinical trials. However, the prevalence may have been underestimated because the information was retrospectively collected in the studies. Methods Between April and December 2014, we prospectively inquired about the frequency of noticing tablet remnants of NVP XR in stools in HIV-1-infected patients who switched to antiretroviral regimens containing NVP XR plus 2 nucleos(t)ide reverse-transcriptase inhibitors. Patients were invited to participate in therapeutic drug monitoring of plasma concentrations of NVP 12 or 24 hours after taking the previous dose (C12 and C24, respectively) of NVP XR using high-performance liquid chromatography. The information on clinical characteristics, including plasma HIV RNA load and CD4 lymphocyte count, at baseline and during follow-up was recorded. Results During the 9-month study period, 272 patients switched to NVP XR-based regimens and 60 (22.1%) noticed tablet remnants of NVP XR in stools, in whom 54.2% reported noticing the tablet remnants at least once weekly. Compared with patients who did not notice tablet remnants, those who noticed tablet remnants had a higher mean CD4 lymphocyte count (629 vs 495 cells/mm3, P = 0.0002) and a similar mean plasma HIV RNA load (1.57 vs 1.61 log10 copies/mL, P = 0.76) on switch. At about 12 and 24 weeks after switch, patients who noticed tablet remnants continued to have a similar mean plasma HIV RNA load (1.39 vs 1.43 log10 copies/mL, P = 0.43; and 1.30 vs 1.37 log10 copies/mL, P = 0.26, respectively), but had a lower median NVP C12 (3640 vs 4730 ng/mL, P = 0.06), and a similar median NVP C24 (3220 vs 3330 ng/ml, P = 0.95) when compared with those who did not notice tablet remnants. Conclusions The presence of tablet remnants of NVP XR in stools is not uncommon in HIV-1-infected Taiwanese patients receiving NVP XR-based antiretroviral regimens, which does not have an adverse impact on the virological and immunological outcomes.

Human beings spend approximately one third of their lives sleeping. Conventionally, to evaluate a subjects sleep quality, all-night polysomnogram (PSG) readings are taken and scored by a well-trained expert. Unlike a bulky PSG or EEG recorder on the head, the development of an electrooculogram (EOG)-based automatic sleep-staging system will enable physiological computing systems (PhyCS) to progress toward easy sleep and comfortable monitoring. In this paper, an EOG-based sleep scoring system is proposed. EOG signals are also coupling some of sleep characteristics of EEG signals. Compared to PSG or EEG recordings, EOG has the advantage of easy placement, and can be operated by the user individually at home. The proposed method was found to be more than 83 % accurate when compared with the manual scorings applied to sixteen subjects. In addition to sleep-quality evaluation, the proposed system encompasses adaptive brightness control of light according to online monitoring of the users sleep stages. The experiments show that the EOG-based sleep scoring system is a practicable solution for homecare and sleep monitoring due to the advantages of comfortable recording and accurate sleep staging.