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The Kuroshio intrusion into the South China Sea (SCS) in summer is weak and has rarely been reported by in situ observations. Here, we describe a new form of Kuroshio water intrusion that is strongest during the summer, the North Luzon Warm Eddy (NLWE), which is an anticyclonic eddy originating north of Luzon Island. From early July to mid-September 2018, two NLWEs moving northwestward were captured by a mooring array consisting of 27 current- and pressure-recording inverted echo sounders (CPIESs). The three-dimensional CPIES estimates reveal that the NLWEs carried large amounts of saline Kuroshio waters (S > 34.7 psu) in the subsurface, which was also evidenced by Argo float profiles. The Kuroshio intrusion was confined to waters shallower than the 14.8°C isotherm. Historical data for NLWEs suggest that they occur mostly during the summer but are absent between November and March, which is attributed to seasonal wind stress curl (WSC). However, because the seasonal signal of WSC during summer is small, intraseasonal WSC is directly responsible for the generation of NLWEs. Significance Statement This paper describes a new type of Kuroshio water intrusion into the South China Sea (SCS)—the North Luzon Warm Eddy (NLWE), which is an anticyclonic eddy generated north of Luzon Island. The eddy mostly occurs during summer when the Kuroshio intrusion is commonly considered the weakest. From observations of a large CPIES array, we provide a cradle-to-grave picture of the NLWE. NLWEs are estimated to contribute almost half of the westward Luzon Strait transport during the summer and, as such, play an important role in the seasonal stratification and circulation in the northeastern SCS.

Topographic Rossby waves (TRWs) play an important role in deep-ocean dynamics and abyssal intraseasonal variations. Observational records from 15 current- and pressure-recording inverted echo sounders (CPIESs) and two moorings deployed in the northern Manila Trench (MT), South China Sea (SCS), for over 400 days were utilized to analyze the widely existing near-21-day bottom-trapped TRWs in the trench. The TRWs were generally generated in winter and summer, dominated by perturbations in the upper ocean. Kuroshio intrusion and its related variabilities contributed to the perturbations in winter, whereas the perturbations generated north of Luzon Island dominated in summer. Eddies north of Luzon propagated northwestward in the summer of 2018; however, these eddies caused the Kuroshio meanderings in the Luzon Strait (LS) in the summer of 2019. The variations in the Kuroshio path and the Kuroshio-related eddies induced TRWs in the deep ocean in regions with steep topography. However, the spatiotemporal distributions of TRWs were complex owing to the propagation of the waves. Some cases of TRWs showed no relation to the local upper-layer perturbations but propagated from adjacent regions. Some of these TRWs were induced by perturbations in the upper ocean in adjacent regions, and propagated anticlockwise in the MT with shallow water to their right, while others may be related to the intraseasonal variations in deep-water overflow in the LS and propagated northward. This study suggests that the Kuroshio and Kuroshio-related eddies significantly contribute to the dynamic processes associated with intraseasonal variations in the deep SCS through the generation of TRWs. Significance Statement Topographic Rossby waves (TRWs) are fluctuations generated when water columns travel across sloping topography under potential vorticity conservation. Based on observations of 15 current- and pressure-recording inverted echo sounders (CPIESs) and two moorings in the northern Manila Trench (MT) in the South China Sea (SCS), TRWs with periods of approximately 21 days were observed and analyzed. This study describes the generation, propagation, and spatiotemporal distribution of TRWs west of the LS and confirms that regional Kuroshio meanderings and upper eddies play important roles in the dynamic processes associated with intraseasonal variations in the deep SCS; the study may thus contribute to knowledge on the dynamic response of the abyssal current to mesoscale perturbations in the upper ocean.

Permanent magnet linear synchronous motor (PMLSM) has a wide application prospect in transmission systems of automatic production, logistics and other fields. However, the existing PMLSM has the problems of poor flexibility and large thrust fluctuation adapted to load and stroke variation. In order to solve this problem, a dual-modular PMLSM is proposed. The motor can be flexibly configured with multiple-unit-primary (MUP) and multiple-unit-secondary (MUS), and achieve low thrust fluctuation. The matching criterion of unit-primary (UP) and secondary is established to reveal the relationship between the slot/pole combination and the winding utilization. The rules of the average thrust varying with the different UP and unit-secondary (US) lengths are illustrated. Then, the matching criterion of different UP is proposed, and the optimization method of the spacing between UP (S1) is obtained by establishing the end force model. The design standard of the optimal S1 is obtained by combining the two factors of minimum detent force and maximum thrust. The results are verified by the simulation and experiments on a 3UP-96US dual-modular PMLSM circular transmission line system and its prototype.

South China Sea (SCS) abyssal circulation largely contributes to water renewal, energy budget, and sedimentary processes in the deep ocean. The three-dimensional abyssal circulation west of the Luzon Strait (LS) in the northern SCS was investigated using an array comprising 27 current- and pressure-recording inverted echo sounders. Over 400 days of measurements from June 2018 to July 2019 showed a narrow and strong (∼70 km, ∼2.3 cm s−1 at 2500 dbar) northward current near the steep eastern boundary, while a wide and weak (∼180 km, ∼1.5 cm s−1 at 2500 dbar) southwestward current lies along the subdued western boundary. The circulation showed conspicuous cyclonic patterns with a volume transport of ∼1.21 ± 0.93 Sv (1 Sv ≡ 106 m3 s−1) and ∼1.59 ± 0.95 Sv below 2500 dbar along the eastern and western boundaries, respectively. The current near the LS was strong in late autumn and early winter but weak in late winter and spring, following the seasonal variation of LS deep-water overflow. However, the southwestward current in the interior SCS was stronger in summer and early autumn but weaker in late winter and early spring. The different seasonal patterns identified near the LS and the interior SCS are attributed to the propagation of seasonal variation. The weak current along the western boundary in August 2018 and February 2019 was dominated by LS deep-water overflow with a time lag of ∼7.5 months. Although eddies in the upper ocean may also contribute to such variation through pressure work, the effect is minor. Significance Statement Cyclonic circulation in the deep South China Sea (SCS) largely contributes to water renewal, energy budget, and sedimentary processes and influences the transport of dissolved elements, minerals, and pollutants. As an important part of the SCS throughflow, an in-depth analysis of the SCS abyssal circulation may also contribute to understanding Indonesian Throughflow and global climate change. The three-dimensional abyssal circulation west of the Luzon Strait was investigated using large-scale data from June 2018 to July 2019, which provided unprecedented coverage of abyssal circulation in the northeast SCS. The study provides important observational evidence for the existence of SCS abyssal cyclonic circulation. Detailed spatiotemporal structure of abyssal circulation and its variations are presented, and related dynamic processes are discussed.

Avian flight feathers have the unique advantages of lightweight and high strength, which play a key role in their flight capacity. In this article, the rachis of the bean goose's primary flight feather was used as the research object. Its compressive properties were analyzed and the 3D microscale was observed by 3D microscope system with a super wide depth of field. The distribution of mechanical properties, section variation of fiber and internal microstructure of rachis were obtained by micro-CT technique. Based on these results, a 3D reconstructed model was established for structure mechanical simulation. The simulation results were close basically to the compressive strength of the actual sample. These results show that the synergistic effect of cortex and medulla can improve mechanical resistance of the rachis. Therefore, the best position (N3) of the primary flight feather shaft can be applied to the bionic design of thin wall structures for energy absorption. This research can provide some guidance for the application of lightweight structural design. Research Highlights: The internal structure of bean goose feather shaft was observed by micro-CT. The experimental method has a deeper understanding of the compressive properties of rachis fiber orientation. Under the synergistic effect of cortex and medulla, the compressive performance of rachis is better.

Background To describe the outcomes of in-bag extraction tissue through the middle part incision of posterior vagina in laparoscopic myomectomy.Methods This was a retrospective study of patients with laparoscopic myomectomy who underwent the middle part incision of posterior vagina to extraction tissue in bag between January 2016 and December 2022. We collected and analyzed data about patients’ characteristics, main indication for surgery, and intra- and postoperative complications.There were 37 cases of vaginal delivery of pregnant women after operation, and there was no laceration of the incision of the posterior wall of the vagina after delivery.Results A total of 511women underwent transvaginal specimen retrieval after laparoscopic myomectomy (mean largest myoma diameter: 8.44 ± 3.56cm; mean specimen weight: 789.23 ± 276.97g; mean operative time: 129.01 ± 53.13minutes; mean blood loss: 175.99 ± 210.96 mL). Within 30-days, no fever, infection, or vaginal bleeding, and the vaginal incisions healed well after 30 days of outpatient review.There was no incisional hernia, pelvic infection and vaginal adhesions during follow-up 3 months after operation.Conclusions The middle part incision of posterior vagina and in-bag transvaginal extraction can be considered a feasible technique at laparoscopic myomectomy.

Mammary gland microbiota is closely related to the progression of breast cancer (BC). Recent studies have shown that Listeria is differentially enriched in breast cancer and normal paracancerous breast tissue, and associated with epithelial-mesenchymal transition (EMT) in breast cancer. However, studies have rarely reported the relationship between Listeria monocytogenes (L. monocytogenes) enrichment and clinical parameters and possible mechanisms in breast cancer. In this study, we found that L. monocytogenes was highly enriched in the cytoplasm of cells, especially in tumor tissues. By analyzing the relationship between L. monocytogenesenrichment and the clinicopathological indicators and prognostic survival of patients, we found that L. monocytogenes is positively correlated with BC proliferation, metastasis, and poor recurrence-free survival (RFS) on patients. Moreover, we performed cell proliferation and invasion assays on breast cancer cells bearing L. monocytogenes, and proved that L. monocytogenes was able to promote the proliferation and invasion of breast cancer cells, their proliferation and invasion capacity was significantly reduced after antibiotic treatment. Mechanistically, L. monocytogenes was identified to increase the survival rate of circulating breast cancer cells by implementing the fluid shear stress model. In conclusion, our study demonstrated that L. monocytogenes could promote breast cancer development by increasing survival rate of circulating cancer cells.

The recycling and reutilization of cotton waste are in line with the sustainable development of society. Therefore, in this work, an environmentally friendly cellulose phosphate ammonium salt was synthesized by phosphorylation of cotton waste. Then the cotton fabrics were modified with cellulose phosphate ammonium salt by using the dip–dry–cure technique to obtain flame-retardant cotton fabric. The surface morphology, characteristic functional groups, and elemental components were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy. The results indicated that the cellulose phosphate ammonium salt was immobilized onto the cotton fabric through a P–O–C chemical bond. Vertical combustion tests before and after washing showed that the treated cotton fabric had durable flame-retardant properties. Thermogravimetry demonstrated that the treated cotton fabric retained a large amount of residual char and the pyrolysis temperature was significantly earlier than that of the control sample. Compared with the blank sample, the peak of heat release rate and total heat release of the modified fabric was reduced by 90.8% and 84.1%, respectively. Thermogravimetric infrared of flame-retardant cotton fabric proved that cellulose phosphate ammonium salt acted both in the gas and condensed phase during the decomposition of the treated fabric.

In this paper, the lunar soil simulant parameters were calibrated using the discrete element method (DEM) for accurate simulation of the interactions between rover wheel and lunar soil simulant. Plackett-Burman, steepest ascent, and Box-Behnken experiments were utilized to propose a parameter calibration methodology. Firstly, the Plackett-Burman experiment was adopted to verify the influences of the nine parameters on the angle of repose (AoR), while three parameters with the most significant effects were identified according to their contributions, and the steepest ascent experiment narrowed their range. Then, the Box-Behnken experiment was utilized for their calibration and obtaining their optimal values. In the simulation, the Hertz–Mindlin (with JKR) contact model was chosen as the contact model. Finally, the calibrated DEM parameters were employed to perform the AoR validation test. The relative error between the simulation and experimental results was 3.4%. The penetration tests were then accomplished further to verify the accuracy and validity of DEM parameters. The penetration resistance curves in the simulation were compatible with the experiment. The obtained results can be utilized for future studies on the interaction between the rover wheel and soil.

A novel phosphorus- and nitrogen-containing flame retardant (APNTHE) was synthesized through the reaction of N, N, N′, N′-tetrakis (2-hydroxypropyl) ethylenediamine, phosphoric acid and urea. Then, the APNTHE solution with a concentration of 120 g/L was used for the preparation of flame retardant cotton (FR-cotton). The elemental compositions, surface morphology, thermal stability and combustion behavior of the cotton before and after modification were investigated. Thermogravimetric (TG) analysis showed that the char residue of the treated fabric at 800°C was as high as 35.09% under a nitrogen atmosphere. Flammability tests after different LCs indicated that FR-cotton had durable flame retardancy. Compared to the blank sample, the peak of heat release rate and total heat release of the FR-cotton decreased by 91.89% and 90.53%, respectively. The char residual and TG-Fourier transform infrared spectroscopy analysis illustrated that APNTHE played a flame retardant role both in the gas phase and the condensed phase. All the results demonstrated that APNTHE can be regarded as a prospective flame retardant for cotton.

The EAZS shows high-performance features even in a wide-temperature range, such as widened voltage window, high energy/power density and ultralong cycle life. Its energy state is visually estimated by color transitions during charging/discharging.

To give silk fabric multiple functions and improve its application range, a facile and eco-friendly one-pot technique was used to endow silk fabric with dyeing, flame retardant and ultraviolet (UV)-resistant performance based on a safflower yellow derivative. The structure, surface morphology, elemental composition, thermal properties and combustion behavior of the silk samples before and after modification were all characterized. In addition, the color depth and color fastness of the dyed silk (D-silk) and flame retardant silk (FR-silk) were evaluated and measured. The positive

The previous studies had demonstrated the promising effectiveness and acceptable safety of pyrotinib in patients with HER2‐positive metastatic breast cancer. We aimed to investigate the real‐world data of pyrotinib in complex clinical practice and complement the findings of clinical trials. Two hundred and eighteen patients were included for effectiveness analysis. A total of 62.0% had received two or more lines of systematic therapy, and 95.4% had been exposed to prior anti‐HER2 therapy, with 95.4% receiving trastuzumab, 5.0% receiving pertuzumab, and 40.8% receiving lapatinib. The median progression‐free survival (PFS) was 9.3 months and the objective response rate (ORR) was 44.0%. Patients treated with pyrotinib‐based therapy as first, second, or later line had a median PFS of 15.0, 10.3, and 6.8 months, respectively. Patients treated with pyrotinib and trastuzumab received significant benefit in terms of median PFS compared with pyrotinib alone (10.7 (9.1–12.3) vs. 8.8 (8.1–9.5), p = 0.016). Patients pretreated with lapatinib had a median PFS of 6.9 months. The median PFS time was 7.0 months in patients with brain metastasis. Multivariate Cox regression analyses showed that lines of pyrotinib‐based therapy (1 vs. 2 vs. ≥3), prior treatment with lapatinib, and combination treatments with trastuzumab proved to be independent predictors of PFS. Two hundred and forty‐eight patients were included in the safety analysis, and the results showed that the toxicity of pyrotinib was tolerable, with the most common grade 3/4 adverse event being diarrhea (19.8%). Pyrotinib‐based therapy demonstrated promising efficacy and tolerable toxicity in first‐, second‐, and later‐line treatments and in lapatinib‐treated patients. The combination of pyrotinib and trastuzumab showed advantages in PFS, even for patients resisting trastuzumab. Pyrotinib‐based therapy could be the preferred choice for brain metastasis patients, especially when combined with brain radiotherapy., Pyrotinib‐based therapy demonstrated promising efficacy and tolerable toxicity in first‐, second‐, and later‐line treatments and in lapatinib‐treated patients. Dual anti‐HER2 therapy with pyrotinib and trastuzumab showed advantages in PFS, even for patients resisting trastuzumab. Pyrotinib‐based therapy could be the preferred choice for brain metastasis patients, especially when combined with brain radiotherapy.