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Carbon dioxide (CO2) storage in deep saline aquifers is a vital option for CO2 mitigation at a large scale. Determining storage capacity is one of the crucial steps toward large-scale deployment of CO2 storage. Results of capacity assessments tend toward a consensus that sufficient resources are available in saline aquifers in many parts of the world. However, current CO2 capacity assessments involve significant inconsistencies and uncertainties caused by various technical assumptions, storage mechanisms considered, algorithms, and data types and resolutions. Furthermore, other constraint factors (such as techno-economic features, site suitability, risk, regulation, social-economic situation, and policies) significantly affect the storage capacity assessment results. Consequently, a consensus capacity classification system and assessment method should be capable of classifying the capacity type or even more related uncertainties. We present a hierarchical framework of CO2 capacity to define the capacity types based on the various factors, algorithms, and datasets. Finally, a review of onshore CO2 aquifer storage capacity assessments in China is presented as examples to illustrate the feasibility of the proposed hierarchical framework.

In order to study the deformation of a diaphragm wall and the settlement of surrounding soil under the complicated conditions of the deep and soft soil layer, which is underlying inclined rock and top-down construction method, the construction scheme of suspended diaphragm wall based on the engineering practice of Oujiang North Estuary deep and large foundation pit of Wenzhou S2 railway is proposed, and the research method of numerical simulation is adopted in this article. By using Midas GTS finite element software, a three-dimensional model of deep and large foundation pit excavation with top-down construction method is established, and the internal force, deformation, and surface settlement of surrounding soil of suspended diaphragm wall with different depths into rock (1 m, 2 m, and 4 m) are analyzed. Furthermore, the optimization simulation research on the anchor locking scheme is carried out for the determined footed diaphragm wall. Similarly, the anchor locking scheme at a depth of 1 m into the interface between soil and rock is selected as the supporting scheme of the footed diaphragm wall through the simulation results. The research results of this article can guarantee the safety of diaphragm wall construction of deep and large foundation pit in complex stratum.

The white pulp of the Chinese water chestnut (CWC) is crisp and sweet with delicious flavours and is an important ingredient in many Chinese dishes. Phenylacetaldehyde is a characteristic flavoured substance produced in the steaming and cooking process of CWC. The steaming process and conditions were simulated to construct three Maillard reaction systems which consisted of glucose and phenylalanine, and of both alone. The simulation results showed that glucose and phenylalanine were the reaction substrates for the formation of phenylacetaldehyde. The intermediate α-dicarbonyl compounds (α-DCs) and the final products of the simulated system were detected by solid-phase microextraction (SPME) and gas chromatography–mass spectrometry (GC-MS) methods. Through the above methods the formation mechanism of phenylacetaldehyde is clarified; under the conditions of the steaming process, glucose is caramelized to produce Methylglyoxal (MGO), 2,3-Butanedione (BD), Glyoxal (GO) and other α-DCs. α-DCs and phenylalanine undergo a Strecker degradation reaction to generate phenylacetaldehyde. The optimal ratio of the amount of substance of glucose to phenylalanine for Maillard reaction is 1:4. The results can provide scientific reference for the regulation of flavour substances and the evaluation of flavour quality in the steaming process of fruits and vegetables.

Abstract Schistosomiasis is a globally important helminthic disease of humans and animals, and it is the second most common parasitic disease after malaria. Eggs produced by mature females are responsible for the disease’s occurrence and spread. Frzb2, a secreted frizzled-related protein, can inhibit Wnt signalling by competitive binding to the specific frizzled protein receptor. In this study, the complete gene sequence of SjFrzb2 was obtained by using 3′-rapid amplification of cDNA ends technology. SjFrzb2 transcript levels at different stages of S. japonicum maturation were evaluated by quantitative real-time RT-PCR analysis. SjFrzb2 was expressed at all developmental stages examined and exhibited the highest transcription level in 7-day-old worms, then gradually decreased during the growth and developmental stages to reach the lowest level at 18 days post-infection. SjFrzb2 gene expression was higher in female worms than in male worms and was significantly higher in female worms from a single-sex infection than in female worms from a bisexual infection. The functions of SjFrzb2 were explored via a small interfering RNA-based gene silencing approach and the soaking method. The results showed that SjFrzb2 gene knockdown impaired the growth and development of S. japonicum in mice, affecting not only the survival and morphological structure of the worms but also their reproductive ability and the viability of the produced eggs. Collectively, these observations imply that Frzb2 may be a novel target for the development of immuno- and/or small molecule-based therapeutics to control schistosomiasis fecundity and transmission.

Background: Skin sympathetic nerve activity (SKNA) and QT interval variability are known to be associated with ventricular arrhythmias. However, the relationship between the two remains unclear.Objective: The aim was to test the hypothesis that SKNA bursts are associated with greater short-term variability of the QT interval (STVQT) in patients with electrical storm (ES) or coronary heart disease without arrhythmias (CHD) than in healthy volunteers (HV).Methods: We simultaneously recorded the ECG and SKNA during sinus rhythm in patients with ES (N = 10) and CHD (N = 8) and during cold-water pressor test in HV (N = 12). The QT and QTc intervals were manually marked and calculated within the ECG. The STVQT was calculated and compared to episodes of SKNA burst and non-bursting activity.Results: The SKNA burst threshold for ES and HV was 1.06 ± 1.07 and 1.88 ± 1.09 μV, respectively (p = 0.011). During SKNA baseline and burst, the QT/QTc intervals and STVQT for ES and CHD were significantly higher than those of the HV. In all subjects, SKNA bursts were associated with an increased STVQT (from 6.43 ± 2.99 to 9.40 ± 5.12 ms, p = 0.002 for ES; from 9.48 ± 4.40 to 12.8 ± 5.26 ms, p = 0.016 for CHD; and from 3.81 ± 0.73 to 4.49 ± 1.24 ms, p = 0.016 for HV). The magnitude of increased STVQT in ES (3.33 ± 3.06 ms) and CHD (3.34 ± 2.34 ms) was both higher than that of the HV (0.68 ± 0.84 ms, p = 0.047 and p = 0.020).Conclusion: Compared to non-bursting activity, SKNA bursts were associated with a larger increase in the QTc interval and STVQT in patients with heart disease than in HV.

Chinese water chestnut (CWC) is popular among consumers due to its unique flavor and crisp and sweet taste. Thus far, the key substances affecting the taste compound of CWC are still unclear. In this study, we used UPLC-MS/MS and an electronic tongue system to study the effects of four typical steaming and cooking methods, cooking without peel for 10 min (PC), steaming without peel for 15 min (PS), cooking with peel for 30 min (WPC), steaming with peel for 30 min (WPS), on the taste compound generation and variation of CWC, and revealed the secret of its crisp and sweet taste. The results show that the electronic tongue can effectively identify the taste profile of CWC, and the effective tastes of CWC were umami, bitterness, saltiness, and sweetness. We screened 371 differential compounds from 640 metabolic species. Among them, nucleotides and their derivatives, carbohydrates, organic acids and their derivatives, and amino acids and their derivatives are closely related to the key taste of CWC, and these compounds affected the taste of CWC through six related metabolic pathways: oxidative phosphorylation and purine metabolism; alanine, aspartate, and glutamate; bile secretion; amino sugar and nucleotide sugar metabolism; the phenylpropane pathway; and toluene degradation. This study reveals the potential metabolic causes of taste compound generation and variation in the taste of CWC.

Incorporating and dispersing dense nanoparticles into metals remains a challenge. Here, the authors use nanocomposite powders containing very dense nanoparticles to print an aluminium nanocomposite with one of the highest specific modulus and yield strength among all structural materials.

Carbon capture, utilization and storage (CCUS) is considered as a very important technology for mitigating global climate change. Carbon dioxide (CO2) injected into an underground reservoir will induce changes in its physical properties and the migration of CO2 will be affected by many factors. Accurately understanding these changes and migration characteristics of CO2 is crucial for selecting a CCUS project site, estimating storage capacity and ensuring storage security. In this paper, the basic principles of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) technologies are briefly introduced in the context of laboratory experiments related to CCUS. The types of NMR apparatus, experimental samples and testing approaches applied worldwide are discussed and analyzed. Then two typical NMR core analysis systems used in CCUS field and a self-developed high-pressure, low-field NMR rock core flooding experimental system are compared. Finally, a summary of the current deficiencies related to NMR applied to CCUS field is given and future research plans are proposed. Keywords: Geologic carbon storage, Nuclear magnetic resonance (NMR), Core flooding, Experimental apparatus, Low-field NMR, High-field NMR

Evidence for blood pressure-lowering effects of vitamin C (VC) supplementation in clinical trials is inconsistent and limited studies have examined the effect of VC supplementation on hypertension (HTN) control. In this study, eligible patients were cluster assigned to receive 300 mg VC per day or nothing for 6 months. During the 6-month follow-up period, a questionnaire survey was obtained and standardized blood pressure measurements were performed on all subjects. Oral administration of VC significantly decreased the diastolic blood pressure and pulse pressure with a significant increase in HTN control. After adjusting for confounding variables, treatment with VC was associated with ~ 0.5 risk reduction of uncontrolled HTN in subjects received anti-hypertensive medications, whereas lower indoor and outdoor and ground temperature were significantly associated with an increased risk of uncontrolled HTN in all patients. Our results warrant further studies investigating the mechanisms underlying the association between VC and HTN control.

Abstract Nano-treating is a novel concept wherein a low percentage of nanoparticles is used for microstructural control and property tuning in metals and alloys. The nano-treating of AA7075 was investigated to control its microstructure and improve its structural stability for high performance. After treatment with TiC nanoparticles, the grains were significantly refined from coarse dendrites of hundreds of micrometers to fine equiaxial ones smaller than 20 μm. After T6 heat treatment, the grains, with an average size of 18.5 μm, remained almost unchanged, demonstrating an excellent thermal stability. It was found that besides of growth restriction factor by pinning behavior on grain boundries, TiC nanoparticles served as both an effective nucleation agent for primary grains and an effective secondary phase modifier in AA7075. Furthermore, the mechanical properties of nano-treated AA7075 were improved over those of the pure alloy. Thus, nano-treating provides a new method to enhance the performance of aluminum alloys for numerous applications.

Abstract Background We previously reported the results of a multicentric prospective randomized trial of chemo-refractory metastatic breast cancer patients testing the efficacy of two doses of TGFβ blockade during radiotherapy. Despite a lack of objective responses to the combination, patients who received a higher dose of TGFβ blocking antibody fresolimumab had a better overall survival when compared to those assigned to lower dose (hazard ratio of 2.73, p = 0.039). They also demonstrated an improved peripheral blood mononuclear cell (PBMC) counts and increase in the CD8 central memory pool. We performed additional analysis on residual PBMC using single cell network profiling (SCNP). Methods The original trial randomized metastatic breast cancer patients to either 1 or 10 mg/kg of fresolimumab, every 3 weeks for 5 cycles, combined with radiotherapy to a metastatic site at week 1 and 7 (22.5 Gy given in 3 doses of 7.5 Gy). Trial immune monitoring results were previously reported. In 15 patients with available residual blood samples, additional functional studies were performed, and compared with data obtained in parallel from seven healthy female donors (HD): SCNP was applied to analyze T cell receptor (TCR) modulated signaling via CD3 and CD28 crosslinking and measurement of evoked phosphorylation of AKT and ERK in CD4 and CD8 T cell subsets defined by PD-1 expression. Results At baseline, a significantly higher level of expression (p

Emopamil-Binding Protein (EBP), is an endoplasmic reticulum membrane protein involved in cholesterol biosynthesis, autophagy and oligodendrocyte formation. Here, authors report two crystal structures of human EBP and identify a pharmacological binding site that accommodates multiple different ligands.

In contrast to steels, fusion welding high strength aluminum alloys such as AA7075 is notoriously difficult. Here, the authors add nanoparticles to a weld filler rod to successfully weld AA7075 without hot cracks or loss of strength at the weld.

In this paper, we concern with the split feasibility problem (SFP) in real Hilbert space whenever the sets involved are nonempty, closed, and convex. By mixing W-mapping with the viscosity, we introduce a new iterative algorithm for solving the split feasibility problem, and we prove that our proposed algorithm is convergent strongly to a solution of the split feasibility problem.

Air pollution is the environmental issue of greatest concern in China, especially the PM2.5 pollution in the Beijing–Tianjin–Hebei urban agglomeration (BTHUA). Based on sustainable development, it is of interest to study the spatiotemporal distribution of PM2.5 and its influencing mechanisms. This study reveals the temporal evolution and spatial clustering characteristic of PM2.5 pollution from 2015 to 2019, and quantifies the drivers of its natural and socioeconomic factors on it by using a geographical temporal weighted regression model. Results show that PM2.5 concentrations reached their highest level in 2015 before decreasing in the following years. The monthly averages all present a U-shaped change trend. Relative to the traditional high concentrations in the northern part of the BTHUA domain in 2015, the gap in pollution between the north and south has reduced since 2018. The obvious spatial heterogeneity was demonstrated in both the strength and direction of the variables. This study may help identify reasons for high PM2.5 concentrations and suggest appropriate targeted control and prevention measures.

The permeability of coal is an indispensable parameter for predicting the coalbed methane (CBM) and enhanced CBM (ECBM) production. Considering the low permeability characteristics of coal, the permeability is usually measured by the transient technique in the laboratory. Normally, it is assumed that the calculated permeability will not greatly vary if the pulse pressure applied in the experiment is small (less than 10% of pore pressure) and previous studies have not focused on the effect of the pulse pressure on the measurement permeability. However, for sorptive rock, such as coals and shales, the sorption effect may cause different measurement results under different pulse pressures. In this study, both nonadsorbing gas (helium) and adsorbing gas (carbon dioxide) were used to investigate the adsorption effect on the gas permeability of coal measurement with the pulse-decay technique. A series of experiments under different pore pressures and pulse pressures was performed, and the carbon dioxide permeability was calculated by both Cui et al.’s and Jones’ methods. The results show that the carbon dioxide permeability calculated by Jones’ method was underestimated because the adsorption effect was not considered. In addition, by comparing the helium and carbon dioxide permeabilities under different pulse pressures, we found that the carbon dioxide permeability of coal was more sensitive to the pulse pressure due to the adsorption effect. Thus, to obtain the accurate permeability of coal, the effect of adsorption should be considered when measuring the permeability of adsorptive media with adsorbing gas by the transient technique, and more effort is required to eliminate the effect of the pulse pressure on the measured permeability.

Geothermal energy is an important resource to substitute for traditional fossil fuels. The mechanical properties of reservoir rock under the conditions of water and scCO2 injection at different temperatures are crucial for the safety of Enhanced Geothermal Systems. However, the effects of working fluid on the mechanical properties of granite at in situ temperatures are still rarely reported. To reveal the impact mechanisms, conventional triaxial compression experiments were conducted on granite specimens with different confining pressures (2–20 MPa), different pore fluid (10 MPa water or CO2), and different temperatures (25–150°C) in the present study. SEM analyses were applied to the specimens to determine failure surface morphologies after the experiments. The experimental results show that the effective confining pressure, pore fluid, and temperature have significant effects on the strength of granite specimens. The strength of granite increases with the increase of effective confining pressure, with similar granite strength under the same effective confining pressure (dry, water, and CO2). Temperature strengthening of granite is limited by high confining pressure (∼15 MPa). Under the effective confining pressure of 5 MPa, temperature weakening occurs on granite specimens when temperature is higher than 90°C. There is fluid diffusion in the specimens during compression. The higher viscosity of water may cause a temporary decrease in effective confining pressure, which may increase the strength of granite. The growth or formation of cracks is mainly observed in quartz and feldspar grains without short-term chemical effects. More visible cracks are observed on the specimens and more volume of fluid is injected under CO2 injection conditions, which may be beneficial to increase the permeability of geothermal reservoir.

Transient receptor potential mucolipin 1 (TRPML1) is a lysosomal channel which maintains the low pH and calcium levels for lysosomal function. Here authors use structural biology and electrophysiology to show how lipids bind and allosterically activate TRPML1.

Abstract There is a longstanding challenge to disperse metal nanoparticles uniformly in bulk polymers for widespread applications. Conventional scale-down techniques often are only able to shrink larger elements (such as microparticles and microfibers) into micro/nano-elements (i.e. nanoparticles and nanofibers) without much altering their relative spatial and size distributions. Here we show an unusual phenomenon that tin (Sn) microparticles with both poor size distribution and spatial dispersion were stretched into uniformly dispersed and sized Sn nanoparticles in polyethersulfone (PES) through a stack and draw technique in thermal drawing. It is believed that the capillary instability plays a crucial role during thermal drawing. This novel, inexpensive, and scalable method overcomes the longstanding challenge to produce bulk polymer-metal nanocomposites (PMNCs) with a uniform dispersion of metallic nano-elements.

Abstract Storing CO2 in underground saline aquifers is an important way to reduce CO2 emission in atmosphere, where gas/fluid diffusion in clay plays a key role in CO2 leakage and migration. Various diffusivities, self-diffusivity, Maxwell–Stefan (M–S) diffusivity and Fick diffusivity, in clay interlayer are investigated by molecular dynamics (MD). Self-diffusivity varies with CO2 concentration, and reaches the maximum value at 2 molecules/unit-cell. High fluid concentration leads to clay swelling, thereby increasing self-diffusivity. However, the fractional free volume of clay explains the trend of CO2 self-diffusivity, which does not decrease with CO2 concentration monotonously but reaches the maximum when CO2 concentration reaches 2. Displacement distribution of CO2 molecules is analysed to explore the microscopic diffusion mechanism, which is characterised by logarithmic normal distribution. The mean value of such distribution further explains the self-diffusivity dependence on CO2 concentration. M–S and Fick diffusivities of CO2 are calculated by MD for the first time, both of which increase with increasing CO2 and H2O concentration and temperature. Based on self-diffusivity and M–S diffusivity, a quantity representing the coupling strength between CO2 molecules is presented; it increases firstly with CO2 concentration but begins to decrease when CO2 concentration is beyond 2.

We introduce the value of information obtained by comparing alternative crystal forms of the same sub-state (of outward open UlaA, our example protein), which is found in the same lattice configuration but different space groups. We compare instability estimates obtained using this new method (alternative crystal forms) with temperature factors. Using a transport assay result, we correlate observations for two homologous secondary structure elements, and show that the alternative states method for obtaining instability estimates provide differentiating information about an important and immobilized mid-TMS region. The data presented in this article are related to the article entitled “The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism” (A. Vastermark, A. Driker, J. Weng, X. Li, J. Wang, M.H. Saier Jr., 2016).

A material with a deep melted zone (MZ) but small heat-affected zone (HAZ) is ideal for manufacturing, but improving one zone comes at the expense of the other. Here, the authors resolve this contradiction in metals by adding nanoparticles, which change the metals’ properties in such a way that both expands MZ and minimizes HAZ.

A major challenge for alloy applications is to achieve thermal stability of phase transitions and anti-oxidation properties. Given the stability of ceramic nanoparticles, we propose the incorporation of WC nanoparticles as a novel way to tune the thermal stability of Cu-40 wt% Zn, which is an important alloy known as naval brass. In situ XRD and DSC results confirmed the enhanced thermal stability of Cu-40 wt% Zn/10 vol% WC nanocomposites at higher temperatures were observed for both phase transitions and oxidation. The underlying mechanisms behind Zn diffusion during phase change and oxygen contact are discussed to understand the phenomena. Optical profiles along with SEM and FIB images reveal the morphologies and microstructures of different stages and give supporting information for the above argument. Due to the kinetic and dynamic impedance on Zn diffusion and the intrinsic stability of WC, the higher thermal stability in Cu-40 wt% Zn/WC is achieved. This study provides an effective way to tune thermal stability of alloys, control phase change, and vary post-oxidation morphology. Keywords: Metal matrix nanocomposite, Thermal stability, Phase transition, Anti-oxidation, In situ, ZnO

Semaphorins (SEMAs) and their Plexin (PLXN) receptors are central regulators of metazoan cellular communication. SEMA-PLXND1 signaling plays important roles in cardiovascular, nervous, and immune system development, and cancer biology. However, little is known about the molecular mechanisms that modulate SEMA-PLXND1 signaling. As PLXND1 associates with GIPC family endocytic adaptors, we evaluated the requirement for the molecular determinants of their association and PLXND1’s vascular role. Zebrafish that endogenously express a Plxnd1 receptor with a predicted impairment in GIPC binding exhibit low penetrance angiogenesis deficits and antiangiogenic drug hypersensitivity. Moreover, gipc mutant fish show angiogenic impairments that are ameliorated by reducing Plxnd1 signaling. Finally, GIPC depletion potentiates SEMA-PLXND1 signaling in cultured endothelial cells. These findings expand the vascular roles of GIPCs beyond those of the Vascular Endothelial Growth Factor (VEGF)-dependent, proangiogenic GIPC1-Neuropilin 1 complex, recasting GIPCs as negative modulators of antiangiogenic PLXND1 signaling and suggest that PLXND1 trafficking shapes vascular development.

This data article presents the first systematic assessment on the potential of onshore CO2-enhanced water recovery (CO2-EWR) using pure CO2 streams from industrial separation processes by this evaluation framework. The evaluation framework is developed for CO2 capture, geological utilization and storage (CCUS) project developments, including CO2 emission inventory, site suitability evaluation, and source–sink matching with techno-economic models. The data shows the matched source (CO2 source)-sink (onshore aquifer site) pairs with sites distribution and levelized cost under various scenarios. Data also shows the geographic distribution of source-sink pairs, cost curve, annual cumulative CO2 storage capacity and enhanced water production under various scenarios. Potential large-scale deployments of CO2-EWR projects with low cost in the modern coal chemical industry in China are shown and identified in the dataset. This data article is related to the research article “Cost curve of large-scale deployment of CO2-enhanced water recovery technology in modern coal chemical industries in China” (X. Li et al. 2019).

In order to explore the process of acid- and CO2-induced degradation of wellbore cement and the development of pre-existing leakage channels in wellbore cement under sulfate-rich geological CO2 storage conditions, wellbore cement samples were immersed in SO42--bearing brine solution for 7 days, and the samples after reacting with the low and circumneutral pH solutions were scanned by a micro-CT scanner. HCl+Na2SO4 solution was used to simulate the low-pH condition in deep formation waters and the possible existence of high sulfate ion content in deep formation waters. The acidification and carbonation results were compared, and the results given different pH values and different curing conditions were compared as well. The results show that the degradation of cement was related to the pH value of the reaction solution. There was a significant dissolution in the exterior of the cement sample after exposure to the low-pH solution, but the dissolution surrounding a penetrating borehole at the center of the sample (mimicking a leakage pathway within the wellbore cement in geological CO2 storage environment) was limited. Comparison between acidification and carbonation results in this study shows formation of a thick carbonate layer due to cement carbonation, and this layer was not observed in the acidification result. As for different curing conditions of cement samples, no significant difference in cement alteration depth was observed for the acidification case. For the carbonation case, precipitations in the borehole occurred in the cement sample cured at ambient pressure, while the cement sample cured at high pressure did not produce any precipitation in the borehole. This study provides valuable information on how low pH-induced corrosion and HCO3--induced cement carbonation contribute to structure evolution of wellbore cement in SO42--bearing brine under geological CO2 storage environment.

Depleted gas reservoirs are important potential sites for CO2 geological sequestration due to their proven integrity and safety, well-known geological characteristics, and existing infrastructures and wells built for natural gas production. The Sichuan Basin has a large number of gas fields in which approximately 5.89×109 tons of CO2 can be stored. The Huangcaoxia gas field has the best opportunity in the eastern Sichuan Basin for a pilot project of CO2 sequestration due to its relatively large storage capacity and the nearly depleted state. A coupled thermal-hydrodynamic model including faults is built based on the geological and hydrogeological conditions in the Huangcaoxia gas field. The results of the numerical simulations show that the downhole temperature is above 80°C at a downhole pressure of 14 MPa under the constraint of temperature drop in the reservoir due to the strong Joule-Thomson effect. The corresponding injection pressure and temperature at the wellhead are 10.5 MPa and 60°C, respectively. The sizes of the pressure and CO2 plumes after an injection of 10 years are 18 km and 5 km, respectively. The zone affected by temperature change is very small, being about 1-2 km away from the injection well. The injection rate in the injection well Cao 31 averages 6.89 kg/s (21.73×104 tons/a). For a commercial-scale injection, another four wells (Cao 9, Cao 30, Cao 6, and Cao 22) can be combined with the Cao 31 well for injection, approaching an injection rate of 35 kg/s (1.10×106 tons/a). Both the pressure and temperature of CO2 injection decrease with the increasing depleted pressure in the gas reservoir when the latter is below 6 MPa. With the technique of CO2-enhanced gas recovery (CO2-EGR), the CO2 injection rate is improved and approximately 1.58×107 kg of gas can be produced during a studied time period of 10 years.

Injecting CO2 into a reservoir disturbs the geostress field, which leads to variations in the permeability of caprock and affects its sealing performance. In this paper, the evolution characteristics of the permeability of Yingcheng mudstone were experimentally studied during deviatoric compression under different confining pressures. As the confining pressure increased, the strength of the mudstone increased bilinearly, the angle between the fault and the maximum principle stress increased, and the fault became flatter. During compression, the permeability of mudstone first decreased and then increased and the turning point of the permeability was between the onset of dilatancy and the turning point of volumetric strain; when the fault formed, the permeability increased sharply and the fault-induced increment was reduced exponentially with increasing confining pressure. In addition, the mudstone transformed to the ductile failure mode when the effective confining pressure was greater than 35 MPa, which means that the permeability did not jump within a small strain. Finally, a practical strain-based model of permeability evolution that separately considers compaction and dilatancy was proposed, and the predicted permeability values were in good agreement with the experimental results. This study revealed the effect of confining pressure on permeability evolution during compression and can help evaluate the sealing ability of mudstone caprock.

The ability to produce metal matrix nanocomposites via pressing and infiltration was validated. Al/TiC nanocomposite was used as the model material. Pressing the powder in a die yielded cylindrical specimens with a green density of 1.98 ± 0.05 g/cm3, which was increased to only 2.11 ± 0.12 g/cm3 by sintering. Direct infiltration of the pressed specimens at 1050 °C for 3.5 h yielded specimens with a density of 3.07 ± 0.08 g/cm3, an open porosity of 3.06 ± 1.40%, and an areal void fraction of 8.09 ± 2.67%. The TiC nanoparticles were verified to be well dispersed using energy-dispersive X-ray spectroscopy. The measured hardness of 64 ± 3 HRA makes it a promising material for structural applications in industries such as aerospace and automotive.

Purpose: Maximum dose to the left anterior descending artery (LADmax) is an important physical constraint to reduce the risk of cardiovascular toxicity. We generated a simple algorithm to guide the positioning of the tangent fields to reliably maintain LADmax

Background: This study was designed to investigate whether ginsenoside Rb1 (Rb1) and compound K (CK) ameliorated insulin resistance by suppressing endoplasmic reticulum (ER) stress-induced inflammation in adipose tissue. Methods: To induce ER stress, epididymal adipose tissue from mice or differentiated 3T3 adipocytes were exposed to high glucose. The effects of Rb1 and CK on reactive oxygen species production, ER stress, TXNIP/NLRP3 inflammasome activation, inflammation, insulin signaling activation, and glucose uptake were detected by western blot, emzyme-linked immunosorbent assay, or fluorometry. Results: Rb1 and CK suppressed ER stress by dephosphorylation of IRE1α and PERK, thereby reducing TXNIP-associated NLRP3 inflammasome activation in adipose tissue. As a result, Rb1 and CK inhibited IL-1β maturation and downstream inflammatory factor IL-6 secretion. Inflammatory molecules induced insulin resistance by upregulating phosphorylation of insulin receptor substrate-1 at serine residues and impairing insulin PI3K/Akt signaling, leading to decreased glucose uptake by adipocytes. Rb1 and CK reversed these changes by inhibiting ER stress-induced inflammation and ameliorating insulin resistance, thereby improving the insulin IRS-1/PI3K/Akt-signaling pathway in adipose tissue. Conclusion: Rb1 and CK inhibited inflammation and improved insulin signaling in adipose tissue by suppressing ER stress-associated NLRP3 inflammation activation. These findings offered novel insight into the mechanism by which Rb1 and CK ameliorate insulin resistance in adipose tissue.

The coatings of FeAlCuCrCoMn high entropy alloy were deposited by direct current magnetron sputtering. The microstructure and the mechanical and corrosion properties of the coatings are investigated. A perfect dense and smooth coating could be obtained. The coatings exhibit single FCC solid solution as increasing deposited time. The thickness of the coatings increases with the increasing deposited time, the biggest thicknesses is 1.788 µm. The hardness and Young's modulus of the coatings are 17.5 and 186 GPa, respectively. All coatings exhibit better corrosion resistance than the 201 stainless steel in acidic alkali and salt corrosion mediums.

Pore structure of porous media, including pore size and topology, is rather complex. In immiscible two-phase displacement process, the capillary force affected by pore size dominates the two-phase flow in the porous media, affecting displacement results. Direct observation of the flow patterns in the porous media is difficult, and therefore knowledge about the two-phase displacement flow is insufficient. In this paper, a two-dimensional (2D) pore structure was extracted from a sandstone sample, and the flow process that CO2 displaces resident brine in the extracted pore structure was simulated using the Navier–Stokes equation combined with the conservative level set method. The simulation results reveal that the pore throat is a crucial factor for determining CO2 displacement process in the porous media. The two-phase meniscuses in each pore throat were in a self-adjusting process. In the displacement process, CO2 preferentially broke through the maximum pore throat. Before breaking through the maximum pore throat, the pressure of CO2 continually increased, and the curvature and position of two-phase interfaces in the other pore throats adjusted accordingly. Once the maximum pore throat was broken through by the CO2, the capillary force in the other pore throats released accordingly; subsequently, the interfaces withdrew under the effect of capillary fore, preparing for breaking through the next pore throat. Therefore, the two-phase displacement in CO2 injection is accompanied by the breaking through and adjusting of the two-phase interfaces.

The relative permeability of coal to gas and water is an essential parameter for characterizing coalbed methane (CBM) reservoirs and predicting coal seam gas production, particularly in numerical simulations. Although a variety of studies related to the relative permeability of coals have been conducted, the results hardly meet the needs of practical engineering applications. To track the dynamic development of relative permeability measurements in the laboratory, discover the deficiencies, and discuss further work in this field, this paper investigates the relative permeability measurement preparation work and laboratory methods and summarizes the development of techniques used to determine the water saturation during experimentation. The previously determined relative permeability curves are also assembled and classified according to coal rank and the absolute permeability. It is found that the general operations in the relative permeability measurement process are still not standardized. The techniques applied to determine the water saturation of coal in experiments have been refined to some extent, but no optimal technique has been recognized yet. New techniques, such as the incorporation of high-precision differential pressure gauges, can be used to determine the water production during relative permeability measurement. In addition, the existing relative permeability data are limited, and no study has focused on supercritical carbon dioxide-water and mixed gas (methane and carbon dioxide)-water relative permeability measurements. To meet the requirements of actual projects, further research on this topic must be conducted.

We obtain partial improvement toward the pointwise convergence problem of Schrödinger solutions, in the general setting of fractal measure. In particular, we show that, for $n\geqslant 3$, $\lim _{t\rightarrow 0}e^{it\unicode[STIX]{x1D6E5}}f(x)$$=f(x)$ almost everywhere with respect to Lebesgue measure for all $f\in H^{s}(\mathbb{R}^{n})$ provided that $s>(n+1)/2(n+2)$. The proof uses linear refined Strichartz estimates. We also prove a multilinear refined Strichartz using decoupling and multilinear Kakeya.

The existing investigations on the maximum allowable wellhead injection pressure have found the upper limit of wellhead injection pressure, which, however, cannot provide a practical operational designing scheme of wellhead injection parameters for CO2 geological storage projects. Therefore, this work firstly proposes the complete constraint conditions of wellbore injection to realize the whole process of forward and inverse calculations of wellbore pressure and then applies it to explore the relationship between wellhead injection pressure and injection rate. The results show that the wellhead injection pressure and the injection rate are a pair of mutually constrained physical quantities. For a certain injection project, the allowable wellhead injection pressure and injection rate separately form a continuous interval. Change of one quantity within its allowable interval will also change the other within its interval, both jointly forming a closed region. Thus, controlling the wellhead injection parameters in this closed region can simultaneously ensure the effectiveness and safety of injection. Subsequently, this work further studies the factors of impacting the relationship between wellhead injection pressure and injection rate and finds that all the temperature of injected fluid, the parameters of saturation, and the characteristic parameters of reservoirs only change their upper and lower limits to some extent but have no essential effects on their relationship. Application of this theory and method in Shenhua CCS demonstration project obtained the relationship diagram of wellhead injection pressure and injection rate, which found that its actual injection parameters just fall into the closed region of the relationship diagram, effectively verifying the reliability of this work.

Purpose: To determine feasibility and explore the clinical efficacy of concurrent radiotherapy and carboplatin as adjuvant treatment of triple negative breast cancer (TNBC). Patients and Methods: Women with Stage I-II TNBC were treated after surgery in a phase I–II prospective trial [NCT01289353]. Weekly carboplatin (AUC = 2.0) was delivered for 6 weeks. Concurrent radiotherapy was delivered in the prone position during weeks 2–4, for a total dose of 40.5 Gy in 15 fractions to the breast, and 46.5 Gy in 17 fractions to the tumor bed. Adverse events (AE) were assessed weekly during treatment, once at 45–60 d, and every 6 mo thereafter, using the Common Terminology Criteria for AE (CTCAE) v3.0. Results: A total of 39 patients accrued and 36 received treatment. Eight patients (22%, exact 95% CI: 10%, 39%) developed grade 2 or greater acute radiation dermatitis. Overall, grade 2 AE were seen in nine and grade 3 in two patients. Twenty-three patients (64%) received additional adjuvant chemotherapy. With a median follow-up of 48 mo, 34/36 (94%) are alive and disease free. One patient died of pulmonary failure with possible but unproven breast cancer recurrence, and one patient died of pelvic malignancy. One patient recurred locally and is alive and disease free after surgical management. Brisk lymphocytic infiltrate was present pre-treatment in 39% of 18 patients with evaluable tumor. Conclusions: Adjuvant concurrent carboplatin and prone accelerated radiotherapy is a well-tolerated and promising treatment of early stage TNBC. The observed 3% compares favorably with the expected 30% recurrence rate within 1–4 y from treatment, warranting further studies.

A mutual solubility model for CO2-CH4-brine systems is constructed in this work as a fundamental research for applications of deep hydrocarbon exploration and production. The model is validated to be accurate for wide ranges of temperature (0–250°C), pressure (1–1500 bar), and salinity (NaCl molality from 0 to more than 6 mole/KgW). Combining this model with PHREEQC functionalities, CO2-CH4-brine-carbonate-sulfate equilibrium is calculated. From the calculations, we conclude that, for CO2-CH4-brine-carbonate systems, at deeper positions, magnesium is more likely to be dissolved in aqueous phase and calcite can be more stable than dolomite and, for CO2-CH4-brine-sulfate systems, with a presence of CH4, sulfate ions are likely to be reduced to S2− and H2S in gas phase could be released after S2− saturated in the solution. The hydrocarbon “souring” process could be reproduced from geochemical calculations in this work.

An effective sealing system is crucial for CO2-EOR storage, and these sealing systems are typically composed of the caprocks and faults that surround a reservoir. Therefore, the sealing effectiveness of a caprock-fault system must be evaluated at various stages of CO2-EOR storage projects. This paper presents a new evaluation framework that considers specific site characteristics and a case study on the sealing effectiveness of the caprock-fault system in the Shengli Oilfield. The proposed method is a weighted ranking system where a set of 17 indicators has been developed for the assessment and ranking of the G89 block in terms of their sealing ability for CO2 sequestration. Additional indicators are involved in the method, such as the newly proposed parameter, frontier displacement work which reflects the influence of formation pressure, displacement pressure resistance, and caprock thickness. The new approach considers the sealing mechanisms of caprocks and faults as well as the configuration relationships between them. The method was used to evaluate the sealing effectiveness of the G89 block that has a considerable number of faults and good sealing ability of caprock in the Shengli Oilfield.

Wellbore and site safety must be ensured during CO2 injection into multiple reservoirs during carbon capture and storage projects. This study focuses on multireservoir injection and investigates the characteristics of the flow-rate distribution and reservoir-risk evaluation as well as their unique influences on multireservoir injection. The results show that more CO2 enters the upper layers than the lower layers. With the increase in injection pressure, the risks of the upper reservoirs increase more dramatically than those of the low reservoirs, which can cause the critical reservoir (CR) to shift. The CO2 injection temperature has a similar effect on the injection flow rate but no effect on the CR’s location. Despite having no effect on the flow-rate distribution, the formation-fracturing pressures in the reservoirs determine which layer becomes the CR. As the thickness or permeability of a layer increases, the inflows exhibit upward and downward trends in this layer and the lower layers, respectively, whereas the inflows of the upper layers remain unchanged; meanwhile, the risks of the lower layer and those of the others decrease and remain constant, respectively. Compared to other parameters, the reservoir porosities have a negligible effect on the reservoir risks and flow-rate distributions.

Abstract In the past two decades, research on CO2 storage in coal seams and simultaneously enhanced coalbed methane recovery (ECBM) has attracted a lot of attention due to its win–win effect between greenhouse gas (CO2) emission reduction and coalbed methane recovery enhancement. This paper presents an overview on the current status of research on CO2-ECBM in the past two decades, which involves CO2 storage capacity evaluations, laboratory investigations, modelings and pilot tests. The current status shows that we have made great progress in the ECBM technology study, especially in the understanding of the ECBM mechanisms. However, there still have many technical challenges, such as the definition of unmineable coal seams for CO2 storage capacity evaluation and storage site characterization, methods for CO2 injectivity enhancement, etc. The low injectivity of coal seams and injectivity loss with CO2 injection are the major technique challenges of ECBM. We also search several ways to promote the advancement of ECBM technology in the present stage, such as integrating ECBM with hydraulic fracturing, using a gas mixture instead of pure CO2 for injection into coal seams and the application of ECBM to underground coal mines.

Throughout the several-hundred-year-long history of the concept of strength, inaccurate material strength as a result of the size effect and the inconsistency of strength theories have been two continuous and challenging issues, and have even been taken to be inherent attributes of material strength. Applying the structural stressing state theory and method, this study experimentally investigates the uniaxial load-bearing process of concrete specimens and reveals their stressing state mutation features at specific load levels. Exploration of this general feature resulted in the discovery of essential strength, which is basically without size effect. Then, biaxial and triaxial experiments with concrete specimens were conducted in order to obtain the results for various combinations of principal stresses on essential strength. Consequently, according to Yu’s unified strength theory, the formula for strength of concrete was determined by fitting the relation between the combined principal stresses and the essential strength, which was verified by experiments carried out using natural marble specimens. Essential strength could promote the accuracy of strength indices, and the formula for strength might replace the existing strength theories for brittle materials. The initial solution of these two classic issues could make a new contribution to Yu’s unified strength theory and its final goal, promoting related research on material strength and leading to a more rational use of material strength in practical engineering.

In this paper, we present a facile and cost-effective method to obtain superhydrophobic filter paper and demonstrate its application for efficient water/oil separation. By coupling structurally distinct organosilane precursors (e.g., octadecyltrichlorosilane and methyltrichlorosilane) to paper fibers under controlled reaction conditions, we have formulated a simple, inexpensive, and efficient protocol to achieve a desirable superhydrophobic and superoleophilic surface on conventional filter paper. The silanized superhydrophobic filter paper showed nanostructured morphology and demonstrated great separation efficiency (up to 99.4%) for water/oil mixtures. The modified filter paper is stable in both aqueous solutions and organic solvents, and can be reused multiple times. The present study shows that our newly developed binary silanization is a promising method of modifying cellulose-based materials for practical applications, in particular the treatment of industrial waste water and ecosystem recovery.

Nitrogen (N2) and oxygen (O2) are important impurities obtained from carbon dioxide (CO2) capture procedures. Thermodynamic modeling of CO2-N2-O2-brine-minerals is important work for understanding the geochemical change of CO2 geologic storage with impurities. In this work, a thermodynamic model of the CO2-N2-O2-brine-carbonate system is established using the “fugacity-activity” method, i.e., gas fugacity coefficients are calculated using a cubic model and activity coefficients are calculated using the Pitzer model. The model can calculate the properties at an equilibrium state of the CO2-N2-O2-brine-carbonate system in terms of gas solubilities, mineral solubilities, H2O solubility in gas-rich phase, species concentrations in each phase, pH and alkalinity. The experimental data of this system can be well reproduced by the presented model, as validated by careful comparisons in conditions from surface to high temperature and pressure. The model established in this work is suitable for CO2 geologic storage simulation with N2 or O2 present as impurities.

This study sought to characterize aluminum nanocomposite wires that were fabricated through a cold-rolling process, having potential applications in TIG (tungsten inert gas) welding of aluminum. A206 (Al-4.5Cu-0.25Mg) master nanocomposites with 5 wt % γAl2O3 nanoparticles were first manufactured through a hybrid process combining semi-solid mixing and ultrasonic processing. A206/1 wt % γAl2O3 nanocomposites were fabricated by diluting the prepared master nanocomposites with a monolithic A206 alloy, which was then added to a pure aluminum melt. The fabricated Al–γAl2O3 nanocomposite billet was cold-rolled to produce an Al nanocomposite wire with a 1 mm diameter and a transverse area reduction of 96%. Containing different levels of nanocomposites, the fabricated samples were mechanically and electrically characterized. The results demonstrate a significantly higher strength of the aluminum wires with the nanocomposite addition. Further, the addition of alumina nanoparticles affected the wires’ electrical conductivity compared with that of pure aluminum and aluminum–copper alloys. The overall properties of the new material demonstrate that these wires could be an appealing alternative for fillers intended for aluminum welding.

The ancient Great Wall of China has long suffered from damage due to natural factors and human activities. A small low-cost unmanned helicopter system with a laser scanner and a digital camera is developed to efficiently visualize the status of the huge Great Wall area. The goal of the system is to achieve 3D digitisation of the large-scale Great Wall using a combination of fly-hover-scan and flying-scan modes. However, pose uncertainties of the unmanned helicopter could cause mismatching among point clouds acquired by each hovering-scan. This problem would become more severe as the target area becomes larger and more unstructured. Therefore, a hierarchical optimization framework is proposed in this paper to achieve 3D digitisation of the large-scale unstructured Great Wall with unpredictable pose uncertainties of the unmanned helicopter. In this framework, different optimization methodologies are proposed for the fly-hover-scan and flying-scan modes, respectively, because different scan modes would result in different features of point clouds. Moreover, a user-friendly interface based on WebGL has been developed for 3D model visualization and comparison. Experimental results demonstrate the feasibility of the proposed framework for 3D digitisation of the Great Wall segments.

Let n be a positive integer, and an operator T∈B(ℋ) is called a class A(n) operator if T1+n2/1+n≥|T|2 and n-paranormal operator if T1+nx1/1+n≥||Tx|| for every unit vector x∈ℋ, which are common generalizations of class A and paranormal, respectively. In this paper, firstly we consider the tensor products for class A(n) operators, giving a necessary and sufficient condition for T⊗S to be a class A(n) operator when T and S are both non-zero operators; secondly we consider the properties for n-paranormal operators, showing that a n-paranormal contraction is the direct sum of a unitary and a C.0 completely non-unitary contraction.

Drug-drug interactions (DDIs) are a common cause of adverse drug events. In this paper, we combined a literature discovery approach with analysis of a large electronic medical record database method to predict and evaluate novel DDIs. We predicted an initial set of 13197 potential DDIs based on substrates and inhibitors of cytochrome P450 (CYP) metabolism enzymes identified from published in vitro pharmacology experiments. Using a clinical repository of over 800,000 patients, we narrowed this theoretical set of DDIs to 3670 drug pairs actually taken by patients. Finally, we sought to identify novel combinations that synergistically increased the risk of myopathy. Five pairs were identified with their p-values less than 1E-06: loratadine and simvastatin (relative risk or RR = 1.69); loratadine and alprazolam (RR = 1.86); loratadine and duloxetine (RR = 1.94); loratadine and ropinirole (RR = 3.21); and promethazine and tegaserod (RR = 3.00). When taken together, each drug pair showed a significantly increased risk of myopathy when compared to the expected additive myopathy risk from taking either of the drugs alone. Based on additional literature data on in vitro drug metabolism and inhibition potency, loratadine and simvastatin and tegaserod and promethazine were predicted to have a strong DDI through the CYP3A4 and CYP2D6 enzymes, respectively. This new translational biomedical informatics approach supports not only detection of new clinically significant DDI signals, but also evaluation of their potential molecular mechanisms.

Consider the multiple testing problem of testing m null hypotheses H1,…,Hm, among which m0 hypotheses are truly null. Given the P-values for each hypothesis, the question of interest is how to combine the P-values to find out which hypotheses are false nulls and possibly to make a statistical inference on m0. Benjamini and Hochberg proposed a classical procedure that can control the false discovery rate (FDR). The FDR control is a little bit unsatisfactory in that it only concerns the expectation of the false discovery proportion (FDP). The control of the actual random variable FDP has recently drawn much attention. For any level 1−α, this paper proposes a procedure to construct an upper prediction bound (UPB) for the FDP for a fixed rejection region. When 1−α=50%, our procedure is very close to the classical Benjamini and Hochberg procedure. Simultaneous UPBs for all rejection regions' FDPs and the upper confidence bound for the unknown m0 are presented consequently. This new proposed procedure works for finite samples and hence avoids the slow convergence problem of the asymptotic theory.

The effect of carbon elements on the microstructures and mechanical properties of pure Ti alloys fabricated through extruded powder metallurgy route was investigated. Furthermore, the strengthening mechanism of extruded materials was also investigated quantitatively. In Ti-C materials, the lattice parameter in c-axis of α-Ti increased due to solid solution of carbon atoms in the most stable octahedral interstitial sites. As the carbon contents increased, tensile strength was increased while maintaining a high elongation at break. The 0.2% yield stress of Ti-2.0 mass% TiC increased by 242 MPa compared with pure Ti. The elongation at break value exceeded 35.0% for all specimens. According to this analysis, it was clarified that Fm value of Ti-C materials was 2.90 × 10-10 by using Labusch model. The estimated strengthening improvement using these values was significantly agreed with the experimental results of PM Ti alloys with carbon solution atoms. Furthermore, the strengthening mechanism of the alloys was quantitatively clarified that carbon solution strengthening was the dominant factor in this study. [ABSTRACT FROM AUTHOR]