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Structural basis for PtdInsP2-mediated human TRPML1 regulation
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Transient receptor potential mucolipin 1 (TRPML1) is a lysosomal channel which maintains the low pH and calcium levels for lysosomal function. Here authors use structural biology and electrophysiology to show how lipids bind and allosterically activate TRPML1.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3d5601d34f4f4819b821e2d7b34bcf07
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-06493-7