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264 results on '"Takada, Kohei"'

58. The 2014 autochthonous dengue fever outbreak in Tokyo: A case series study and assessment of the causes and preventive measures

Author

Kori, Mayuko, primary, Awano, Nobuyasu, additional, Inomata, Minoru, additional, Kuse, Naoyuki, additional, Tone, Mari, additional, Yoshimura, Hanako, additional, Jo, Tatsunori, additional, Takada, Kohei, additional, Tanaka, Atsuko, additional, Mawatari, Momoko, additional, Ueda, Akihiro, additional, and Izumo, Takehiro, additional

Published
2020
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60. Chitinase 3-like 1 Produced By Fibrocytes Promotes Myelofibrosis

Author

Kato, Shoichiro, primary, Maekawa, Takaaki, additional, Ogata, Hiraku, additional, Osawa, Yukiko, additional, Kota, Kawasaki, additional, Takada, Kohei, additional, Sone, Takehiro, additional, Saito, Keita, additional, Izumi, Takuya, additional, Nagao, Shigeki, additional, Kosuke, Takano, additional, Okada, Yosuke, additional, Teramoto, Masahiro, additional, Tachi, Noriaki, additional, Kawamura, Toshikuni, additional, Horiuchi, Toshikatsu, additional, Kobayashi, Ayako, additional, Kobayashi, Shinichi, additional, Sato, Ken, additional, Endo-Umeda, Kaori, additional, Uno, Shigeyuki, additional, Morishita, Soji, additional, Araki, Marito, additional, Makishima, Makoto, additional, Komatsu, Norio, additional, and Kimura, Fumihiko, additional

Published
2019
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62. High mortality and poor treatment efficacy of immune checkpoint inhibitors in patients with severe grade checkpoint inhibitor pneumonitis in non‐small cell lung cancer

Author

Tone, Mari, primary, Izumo, Takehiro, additional, Awano, Nobuyasu, additional, Kuse, Naoyuki, additional, Inomata, Minoru, additional, Jo, Tatsunori, additional, Yoshimura, Hanako, additional, Minami, Jonsu, additional, Takada, Kohei, additional, Miyamoto, Shingo, additional, and Kunitoh, Hideo, additional

Published
2019
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67. Comparison of adequacy between transbronchial lung cryobiopsy samples and endobronchial ultrasound‐guided transbronchial needle aspiration samples for next‐generation sequencing analysis.

Author

Tone, Mari, Inomata, Minoru, Awano, Nobuyasu, Kuse, Naoyuki, Takada, Kohei, Minami, Jonsu, Muto, Yutaka, Fujimoto, Kazushi, Kumasaka, Toshio, and Izumo, Takehiro

Subjects
BIOPSY, BRONCHOSCOPY, COMPARATIVE studies, GENES, LONGITUDINAL method, LUNG tumors, NEEDLE biopsy, ULTRASONIC imaging, RETROSPECTIVE studies, DESCRIPTIVE statistics, SEQUENCE analysis
Abstract

Background: Most lung cancer patients present with lesions in both lung fields and lymphadenopathy. Thus, transbronchial lung cryobiopsy (TBLC) and endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) are commonly performed for diagnosing lung cancer. However, the adequacy of these samples for next‐generation sequencing (NGS) analysis remains unclear. This study aimed to compare the adequacy between TBLC and EBUS‐TBNA samples for NGS analysis. Methods: This retrospective cohort study included patients whose lung samples were collected via TBLC or EBUS‐TBNA and analyzed using NGS. Out of 46 genes, the number of genes in TBNA and TBLC samples that could not be assessed via NGS analysis was mainly evaluated. Results: A total of 37 patients were included and classified into two groups (TBLC group, n = 18 and TBNA group, n = 19). The mean number of genes that could not be evaluated via NGS analysis was significantly lower in the TBLC group than in the TBNA group (0.9 vs. 10.3, P = 0.024). The median total area of tumor cells in TBLC samples was significantly greater than that in TBNA samples (6.3 [1.6–4.2] vs. 2.6 [0.2–17.3] mm2, P < 0.01). In the TBNA group, there were two fully inadequate samples for NGS analysis with a high degree of cell crush or low tumor content, while there was no fully inadequate sample in the TBLC group. Conclusions: TBLC is more effective in obtaining adequate samples for NGS analysis than EBUS‐TBNA. TBLC should be performed to obtain adequate samples for NGS analysis in lung cancer patients with target lesions in lung fields, even if they have lymphadenopathy. Key points: Significant findings of the studyThe mean number of genes that could not be evaluated was significantly lower in TBLC samples than in EBUS‐TBNA samples (0.9 vs. 10.3, P = 0.024). TBLC could obtain adequate samples with a high concentration of uncrushed tumor cells for NGS. What this study addsTo obtain samples for NGS analysis, the use of TBLC should be aggressively considered in lung‐cancer patients with target lesions located in lung fields, even if they have lymphadenopathy. [ABSTRACT FROM AUTHOR]

Published
2021
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71. The effect of dynamic stretching on hamstrings flexibility with respect to the spino-pelvic rhythm

Author

Hasebe, Kiyotaka, Okubo, Yu, Kaneoka, Koji, Takada, Kohei, Suzuki, Daisuke, Sairyo, Koichi, Hasebe, Kiyotaka, Okubo, Yu, Kaneoka, Koji, Takada, Kohei, Suzuki, Daisuke, and Sairyo, Koichi

Abstract

Objectives : To ascertain the dynamic stretch effects of flexibility of the hamstrings on lumbar spine and pelvic kinematics. Background : Tight hamstrings are positively correlated with low back pain. However, it is unclear how flexibility of the hamstrings affects spino-pelvic rhythm. Methods : Twelve healthy men participated in the study. The straight leg raising (SLR) angle, finger floor distance (FFD), and spino-pelvic rhythm was measured before and after the 6-week stretching protocol. The forward bending task was divided into 4 phases. The paired t-test was used to determine significant differences before and after the FFD, SLR angle, lumbar motion, and pelvic motion, and spino-pelvic rhythm in each phase (p<0.05). Results : After 6 weeks of stretching, significant improvements were seen in the FFD with maximum forward bending and in the SLR angle. Total pelvic rotation was also significantly increased in contrast to total lumbar flexion. A decreased spino-pelvic ratio was seen in the final phase. Conclusion : Dynamic stretching could change the spino-pelvic rhythm to a pelvis-dominant motion, indicating that flexible hamstrings are important for preventing low back pain.

Published
2016

72. Increased SLAMF7highmonocytes in myelofibrosis patients harboring JAK2V617F provide a therapeutic target of elotuzumab

Author

Maekawa, Takaaki, Kato, Shoichiro, Kawamura, Toshikuni, Takada, Kohei, Sone, Takehiro, Ogata, Hiraku, Saito, Keita, Izumi, Takuya, Nagao, Shigeki, Takano, Kosuke, Okada, Yosuke, Tachi, Noriaki, Teramoto, Masahiro, Horiuchi, Toshikatsu, Hikota-Saga, Reina, Endo-Umeda, Kaori, Uno, Shigeyuki, Osawa, Yukiko, Kobayashi, Ayako, Kobayashi, Shinichi, Sato, Ken, Hashimoto, Michihiro, Suzu, Shinya, Usuki, Kensuke, Morishita, Soji, Araki, Marito, Makishima, Makoto, Komatsu, Norio, and Kimura, Fumihiko

Abstract

Monocyte-derived fibrocytes recently garnered attention because the novel pathogenesis of myelofibrosis (MF), and suppression of fibrocyte differentiation by serum amyloid P remarkably improved MF. We previously revealed that human fibrocytes highly expressed signaling lymphocytic activation molecule F7 (SLAMF7) compared with macrophages and that SLAMF7highmonocytes in the peripheral blood (PB) of MF patients were significantly elevated relative to those in healthy controls (HCs). In this study, we evaluated SLAMF7highmonocyte percentage in the PB of HCs, myeloproliferative neoplasm (MPN) patients with MF, and MPN patients without MF by using a cross-sectional approach. We found that MPN patients with MF who harbored JAK2V617F had a significantly elevated SLAMF7highmonocyte percentage, which correlated positively with the JAK2V617F allele burden. In addition, the serum concentration of interleukin-1ra (IL-1ra) was significantly correlated with the SLAMF7highmonocyte percentage and JAK2V617F allele burden. These findings suggest that both SLAMF7highmonocytes and IL-1ra could be useful noninvasive markers of MF onset. Furthermore, the JAK2V617F allele burden of SLAMF7highmonocytes was significantly higher than that of SLAMF7lowmonocytes and could be a potential target of elotuzumab (Elo), an anti-SLAMF7 antibody used for treating multiple myeloma. Elo independently inhibited differentiation of fibrocytes derived not only from HCs but also from MF patients in vitro. Elo also ameliorated MF and splenomegaly induced by romiplostim administration in humanized NOG mice. In conclusion, an increase of SLAMF7highmonocytes with higher JAK2V617F allele burden was associated with the onset of MF in MPN patients harboring JAK2V617F, and Elo could be a therapeutic agent for MPN patients with MF who harbor JAK2V617F.

Published
2019
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90. An experimental consideration on the effect of antenna gain on the observed PIMs for an external PIM-source.

Author

Takada, Kohei, Kuga, Nobuhiro, and Cho, Keizo

Abstract

Passive Intermodulation (PIM) is caused by non-linearity in passive circuits such as base station antennas in mobile communication systems [1]. When measuring PEVI performances of a microwave device, standard PIM generators are very useful to assess the performance of a measurement system [2]. [ABSTRACT FROM PUBLISHER]

Published
2012

98. High-resolution resist for screen printing: application to direct fabrication of Ag circuit.

Author

Okamura, Haruyuki, Kayanoki, Minoru, Takada, Kohei, Nakajiri, Hideyuki, Muramatsu, Keiko, Yamashita, Munenori, and Shirai, Masamitsu

Subjects
SCREEN process printing, POLYMERS, HIGH resolution imaging, POLYMETHACRYLIC acids, STAINLESS steel
Abstract

High-resolution screen printing was devised. New resist formulation contains a base polymer, which consists of acid-labile tetrahydropyranyl-protected carboxylic acid, hydroxyl, and methacrylic functions. As crosslinkers, multifunctional acrylates were employed. Photoacid generators were used for pattern formation. A 10-µm feature size of resist on a screen plate was obtained on irradiation at 365 nm and followed by development on a stainless steel screen. Post-exposure curing improved the mechanical characteristics of the resist patterns. A 13-µm feature size silver circuit was successfully printed on poly(ethylene terephthalate) film without defect. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2012
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