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58. The functions of Wt1in mouse gonad development and somatic cells differentiation†

Author

Chen, Min, Cen, Changhuo, Wang, Nan, Shen, Zhiming, Wang, Mengyue, Liu, Bowen, Li, Jiayi, Cui, Xiuhong, Wang, Yanbo, and Gao, Fei

Abstract

Wilms’ tumor 1 (Wt1) encodes a zinc finger nuclear transcription factor which is mutated in 15–20% of Wilms’ tumor, a pediatric kidney tumor. Wt1has been found to be involved in the development of many organs. In gonads, Wt1is expressed in genital ridge somatic cells before sex determination, and its expression is maintained in Sertoli cells and granulosa cells after sex determination. It has been demonstrated that Wt1is required for the survival of the genital ridge cells. Homozygous mutation of Wt1causes gonad agenesis. Recent studies find that Wt1plays important roles in lineage specification and maintenance of gonad somatic cells. In this review, we will summarize the recent research works about Wt1in gonadal somatic cell differentiation.Wt1is indispensable for somatic cell differentiation and gonad development at different developmental stages.

Published
2022
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59. Within Animal Comparison of Tract-tracing and High Resolution Tractography Yields High Correlations

Author

Teillac, Achille, Hou, Yujie, Magrou, Loïc, Lamy, Camille, Misery, Pierre, Richard, Nathalie, Descoteaux, Maxime, Ye, Chuyang, Shen, Zhiming, Knoblauch, Kenneth, Kennedy, Henry, Hiba, Bassem, Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut cellule souche et cerveau / Stem Cell and Brain Research Institute (U1208 Inserm - UCBL1 / SBRI - USC 1361 INRAE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sherbrooke Connectivity Imaging Lab [Sherbrooke] (SCIL), Département d'informatique [Sherbrooke] (UdeS), Faculté des sciences [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS)-Faculté des sciences [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS), Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Institute of Neuroscience, (Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences), and HIBA, Bassem

Subjects
[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

61. X-Containers

Author

Shen, Zhiming, primary, Sun, Zhen, additional, Sela, Gur-Eyal, additional, Bagdasaryan, Eugene, additional, Delimitrou, Christina, additional, Van Renesse, Robbert, additional, and Weatherspoon, Hakim, additional

Published
2019
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66. Towards an emergency edge supercloud

Author

Karlsson, Kolbeinn, primary, Shen, Zhiming, additional, Song, Weijia, additional, Weatherspoon, Hakim, additional, van Renesse, Robbert, additional, and Wicker, Stephen, additional

Published
2017
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67. World Congress Integrative Medicine & Health 2017: part two

Author

Ee, Carolyn, primary, Thuraisingam, Sharmala, additional, Pirotta, Marie, additional, French, Simon, additional, Xue, Charlie, additional, Teede, Helena, additional, Kristoffersen, Agnete E., additional, Sirois, Fuschia, additional, Stub, Trine, additional, Engler, Jennifer, additional, Joos, Stefanie, additional, Güthlin, Corina, additional, Felenda, Jennifer, additional, Beckmann, Christiane, additional, Stintzing, Florian, additional, Evans, Roni, additional, Bronfort, Gert, additional, Keefe, Daniel, additional, Taberko, Anna, additional, Hanson, Linda, additional, Haley, Alex, additional, Ma, Haiwei, additional, Jolton, Joseph, additional, Yarosh, Lana, additional, Keefe, Francis, additional, Nam, Jung, additional, Ojala, Liwanag, additional, Kreitzer, Mary J., additional, Fink, Careen, additional, Kraft, Karin, additional, Flower, Andrew, additional, Lewith, George, additional, Harman, Kim, additional, Stuart, Beth, additional, Bishop, Felicity L., additional, Frawley, Jane, additional, Füleki, Lilla, additional, Kiss, Eva, additional, Vancsik, Tamas, additional, Krenacs, Tibor, additional, Funabashi, Martha, additional, Pohlman, Katherine A., additional, Mior, Silvano, additional, Thiel, Haymo, additional, Hill, Michael D., additional, Cassidy, David J., additional, Westaway, Michael, additional, Yager, Jerome, additional, Hurwitz, Eric, additional, Kawchuk, Gregory N., additional, O’Beirne, Maeve, additional, Vohra, Sunita, additional, Gaboury, Isabelle, additional, Morin, Chantal, additional, Gaertner, Katharina, additional, Torchetti, Loredana, additional, Frei-Erb, Martin, additional, Kundi, Michael, additional, Frass, Michael, additional, Gallo, Eugenia, additional, Maggini, Valentina, additional, Comite, Mattia, additional, Sofi, Francesco, additional, Baccetti, Sonia, additional, Vannacci, Alfredo, additional, Di Stefano, Mariella, additional, Monechi, Maria V., additional, Gori, Luigi, additional, Rossi, Elio, additional, Firenzuoli, Fabio, additional, Mediati, Rocco D., additional, Ballerini, Giovanna, additional, Gardiner, Paula, additional, Lestoquoy, Anna S., additional, Negash, Lily, additional, Stillman, Sarah, additional, Shah, Prachi, additional, Liebschutz, Jane, additional, Adelstein, Pamela, additional, Farrell-Riley, Christine, additional, Brackup, Ivy, additional, Penti, Brian, additional, Saper, Robert, additional, Sampedro, Isabel Giralt, additional, Carvajal, Gilda, additional, Gleiss, Andreas, additional, Gross, Marie M., additional, Brendlin, Dorothea, additional, Röttger, Jonas, additional, Stritter, Wiebke, additional, Seifert, Georg, additional, Grzanna, Noelle, additional, Stange, Rainer, additional, Guendling, Peter W., additional, Gu, Wen, additional, Lu, Yan, additional, Wang, Jie, additional, Zhang, Chengcheng, additional, Bai, Hua, additional, He, Yuxi, additional, Zhang, Xiaoxu, additional, Zhang, Zhengju, additional, Wang, Dali, additional, Meng, Fengxian, additional, Hagel, Alexander, additional, Albrecht, Heinz, additional, Vollbracht, Claudia, additional, Dauth, Wolfgang, additional, Hagel, Wolfgang, additional, Vitali, Francesco, additional, Ganzleben, Ingo, additional, Schultis, Hans, additional, Konturek, Peter, additional, Stein, Jürgen, additional, Neurath, Markus, additional, Raithel, Martin, additional, Krick, Bianka, additional, Haller, Heidemarie, additional, Klose, Petra, additional, Dobos, Gustav, additional, Kümmel, Sherko, additional, Cramer, Holger, additional, Saha, Felix J., additional, Kowoll, Anna, additional, Ebner, Barbara, additional, Berger, Bettina, additional, Choi, Kyung-Eun, additional, He, Lisha, additional, Wang, Han, additional, He, X., additional, Gu, C., additional, Zhang, Y., additional, Zhao, Linhua, additional, Tong, Xiaolin, additional, He, Xinhui, additional, Gu, Chengjuan, additional, Zhang, Ying, additional, Ho, Robin S. T., additional, Chung, Vincent C. H., additional, Wu, Xinyin, additional, Wong, Charlene H. L., additional, Wu, Justin C. Y., additional, Wong, Samuel Y. S., additional, Lau, Alexander Y. L., additional, Sit, Regina W. S., additional, Wong, Wendy, additional, Holmes, Michelle, additional, Bishop, Felicity, additional, Calman, Lynn, additional, Newell, Dave, additional, Field, Jonathan, additional, Htut, Win L., additional, Han, Dongwoon, additional, Choi, Da I., additional, Choi, Soo J., additional, Kim, Ha Y., additional, Hwang, Jung H., additional, Huang, Ching W., additional, Jang, Bo H., additional, Chen, Fang P., additional, Ko, Seong G., additional, Huang, Wenjing, additional, Jin, De, additional, Lian, Fengmei, additional, Jang, Soobin, additional, Kim, Kyeong H., additional, Lee, Eun K., additional, Sun, Seung H., additional, Go, Ho Y., additional, Ko, Youme, additional, Park, Sunju, additional, Shin, Yong C., additional, Janik, Hubert, additional, Greiffenhagen, Natalie, additional, Bolte, Jürgen, additional, Jaworski, Mariusz, additional, Adamus, Miroslawa, additional, Dobrzynska, Aleksandra, additional, Jeitler, Michael, additional, Jaspers, Jessica, additional, von Scheidt, Christel, additional, Koch, Barbara, additional, Michalsen, Andreas, additional, Steckhan, Nico, additional, Kessler, Christian, additional, Huang, Wen-jing, additional, Pang, Bing, additional, Lian, Feng-Mei, additional, Jong, Miek, additional, Baars, Erik, additional, Glockmann, Anja, additional, Hamre, Harald, additional, Kainuma, Mosaburo, additional, Murakami, Aya, additional, Kubota, Toshio, additional, Kobayashi, Daisuke, additional, Sumoto, Yasuhiro, additional, Furusyo, Norihiro, additional, Ando, Shin-Ichi, additional, Shimazoe, Takao, additional, Kelber, Olaf, additional, Verjee, S., additional, Gorgus, Eva, additional, Schrenk, Dieter, additional, Kemper, Kathi, additional, Hill, Ellie, additional, Rao, Nisha, additional, Gascon, Gregg, additional, Mahan, John, additional, Kienle, Gunver, additional, Dietrich, Jörg, additional, Schmoor, Claudia, additional, Huber, Roman, additional, Kim, Weon H., additional, Ahmed, Mansoor, additional, He, Luzhu, additional, Hwang, Jung Hye, additional, Meggyeshazi, Nora, additional, Kovago, Csaba, additional, Klaus, Anne K., additional, Zerm, Roland, additional, Pranga, Danilo, additional, Ostermann, Thomas, additional, Reif, Marcus, additional, von Laue, Hans Broder, additional, Brinkhaus, Benno, additional, Kröz, Matthias, additional, Recchia, Daniela Rodrigues, additional, von Laue, Hans B., additional, Klein-Laansma, Christien T., additional, Jong, Mats, additional, von Hagens, Cornelia, additional, Jansen, Jean P., additional, van Wietmarschen, Herman, additional, Jong, Miek C., additional, Sun, Seung-Ho, additional, Go, Ho-Yeon, additional, Jeon, Chan-Yong, additional, Song, Yun-Kyung, additional, Ko, Seong-Gyu, additional, Koch, Anna K., additional, Rabsilber, Sybille, additional, Lauche, Romy, additional, Langhorst, Jost, additional, Trifunovic-Koenig, Milena, additional, Koster, Evi, additional, Delnoij, Diana, additional, Kroll, Lena, additional, Weiss, Kathrin, additional, Kubo, Ai, additional, Hendlish, Sarah, additional, Altschuler, Andrea, additional, Connolly, Nancy, additional, Avins, Andy, additional, Wardle, Jon, additional, Lee, David, additional, Sibbritt, David, additional, Adams, Jon, additional, Park, Crystal, additional, Mishra, Gita, additional, Lechner, Johann, additional, Lee, Inseon, additional, Chae, Younbyoung, additional, Lee, Jisu, additional, Cho, Seung H., additional, Choi, Yujin, additional, Lee, Jee Y., additional, Ryu, Han S., additional, Yoon, Sung S., additional, Oh, Hye K., additional, Hyun, Lyun K., additional, Kim, Jin O., additional, Yoon, Seong W., additional, Lee, Ju-Yeon, additional, Shin, Sang-Hoon, additional, Jang, Min, additional, Müller, Indra, additional, Park, So-Hyun Janson, additional, Laird, Lance, additional, Mitchell, Suzanne, additional, Li, Xiaofei, additional, Wang, Yunhui, additional, Zhen, Jianhua, additional, Yu, He, additional, Liu, Tiegang, additional, Gu, Xiaohong, additional, Liu, Hui, additional, Ma, Weiguo, additional, Shang, Xuezheng, additional, Bai, Yu, additional, Liu, Wei, additional, Rooney, Collin, additional, Smith, Amos, additional, Lopes, Shirlene, additional, Demarzo, Marcelo, additional, do Patrocínio Nunes, Maria, additional, Lorenz, Peter, additional, Gründemann, Carsten, additional, Heinrich, Miriam, additional, Garcia-Käufer, Manuel, additional, Grunewald, Franziska, additional, Messerschmidt, Silke, additional, Herrick, Anja, additional, Gruber, Kim, additional, Knödler, Matthias, additional, Steinborn, Carmen, additional, Lu, Taoying, additional, Wang, Lixin, additional, Wu, Darong, additional, Luberto, Christina M, additional, Hall, Daniel L., additional, Chad-Friedman, Emma, additional, Lechner, Suzanne, additional, Park, Elyse R., additional, Luberto, Christina M., additional, Park, Elyse, additional, Goodman, Janice, additional, Luer, Sonja, additional, Heri, Matthias, additional, von Ammon, Klaus, additional, Landini, Ida, additional, Lapucci, Andrea, additional, Nobili, Stefania, additional, Mini, Enrico, additional, McDermott, Clare, additional, Richards, Selwyn, additional, Cox, Diane, additional, Frossell, Sarah, additional, Leydon, Geraldine, additional, Eyles, Caroline, additional, Raphael, Hilly, additional, Rogers, Rachael, additional, Selby, Michelle, additional, Adler, Charlotte, additional, Allam, Jo, additional, Bu, Xiangwei, additional, Zhang, Honghong, additional, Zhang, Jianpeng, additional, Mikolasek, Michael, additional, Berg, Jonas, additional, Witt, Claudia, additional, Barth, Jürgen, additional, Miskulin, Ivan, additional, Lalic, Zdenka, additional, Miskulin, Maja, additional, Dumic, Albina, additional, Sebo, Damir, additional, Vcev, Aleksandar, additional, Mohammed, Nasr A. A., additional, Choi, Soo Jeung, additional, Im, Hyea Bin, additional, Mukherjee, Anwesha, additional, Kandhare, Amit, additional, Bodhankar, Subhash, additional, Thakurdesai, Prasad, additional, Munk, Niki, additional, Evans, Erica, additional, Froman, Amanda, additional, Kline, Matthew, additional, Bair, Matthew J., additional, Musial, Frauke, additional, Alræk, Terje, additional, Hamre, Harald J., additional, Björkman, Lars, additional, Fønnebø, Vinjar M., additional, Lian, Feng-mei, additional, Ni, Qing, additional, Tong, Xiao-lin, additional, Li, Xin-long, additional, Liu, Wen-ke, additional, Feng, Shuo, additional, Zhao, Xi-yan, additional, Zheng, Yu-jiao, additional, Zhao, Xue-min, additional, Lin, Yi-qun, additional, Zhao, Tian-yu, additional, Zhao, Xi-Yan, additional, Phd, Hui Che, additional, Zhang, Chen, additional, Liu, Feng, additional, Zhao, Lin-hua, additional, Ye, Ru, additional, Gu, Cheng-juan, additional, Peng, Wenbo, additional, De Carvalho, Diana, additional, El-Bayoumi, Mohamed, additional, Haig, Bob, additional, Kelly, Kimbalin, additional, Wade, Darrell J., additional, Portalupi, Emanuela, additional, Gobo, Giampietro, additional, Bellavita, Luigi, additional, Guglielmetti, Chiara, additional, Raak, Christa, additional, Teuber, Myriam, additional, Molsberger, Friedrich, additional, von Rath, Ulrich, additional, Reichelt, Ulrike, additional, Schwanebeck, Uta, additional, Zeil, Sabine, additional, Vogelberg, Christian, additional, Veintimilla, Dolores Rodríguez, additional, Mery, Guerrero Tapia, additional, Villavicencio, Marisol Maldonado, additional, Moran, Sandra Herrera, additional, Sachse, Christian, additional, Gündlin, Peter W, additional, Sahebkarkhorasani, Monirsadat, additional, Azizi, Hoda, additional, Schumann, Dania, additional, Sundberg, Tobias, additional, Leach, Matthew J., additional, Seca, Susana, additional, Greten, Henry, additional, Selliah, Sugir, additional, Shakya, Anu, additional, Kim, Ha Yun, additional, Im, Hyea B., additional, Sherbakova, Anna, additional, Ulrich-Merzenich, Gudrun, additional, Abdel-Aziz, Heba, additional, Sibinga, Erica, additional, Webb, Lindsey, additional, Ellen, Jonathan, additional, Skrautvol, Kari, additional, Nåden, Dagfinn, additional, Song, Rhayun, additional, Grabowska, Weronika, additional, Osypiuk, Kamila, additional, Diaz, Gloria V., additional, Bonato, Paolo, additional, Park, Moonkyoung, additional, Hausdorff, Jeffrey, additional, Fox, Michael, additional, Sudarsky, Lewis R., additional, Tarsy, Daniel, additional, Novakowski, James, additional, Macklin, Eric A., additional, Wayne, Peter M., additional, Hwang, Inok, additional, Ahn, Sukhee, additional, Lee, Myung-Ah, additional, Sohn, Min K., additional, Sorokin, Oleg, additional, Heydeck, Dagmar, additional, Borchert, Astrid, additional, Hohmann, Christoph-Daniel, additional, Kühn, Harmut, additional, Kirschbaum, Clemens, additional, Stalder, Tobias, additional, Stöckigt, Barbara, additional, Teut, Michael, additional, Suhr, Ralf, additional, Sulmann, Daniela, additional, Streeter, Chris, additional, Gerbarg, Patrica, additional, Silveri, Marisa, additional, Brown, Richard, additional, Jensen, John, additional, Rutert, Britta, additional, Eggert, Angelika, additional, Längler, Alfred, additional, Holmberg, Christine, additional, Sun, Jin, additional, Deng, Xin, additional, Li, Wen-Yuan, additional, Wen, Bin, additional, Robinson, Nicola, additional, Liu, Jian-Ping, additional, Sung, Hyun K., additional, Yang, Narae, additional, Shin, Seon M., additional, Jung, Hee, additional, Kim, Young J., additional, Jung, Woo S., additional, Park, Tae Y., additional, Suzuki, Kiyoshi, additional, Ito, Toshinori, additional, Uchida, Seiya, additional, Kamohara, Seika, additional, Ono, Naoya, additional, Takamura, Mitsuyuki, additional, Yokochi, Ayumu, additional, Maruyama, Kazuo, additional, Tapia, Patricio, additional, Thabaut, Katarzyna, additional, Thronicke, Anja, additional, Steele, Megan, additional, Matthes, Harald, additional, Herbstreit, Cornelia, additional, Schad, Friedemann, additional, Tian, Jiaxing, additional, Yang, Libo, additional, Tian, Tian, additional, Zhang, Hewei, additional, Tian, Xia, additional, Wang, CongCong, additional, Chai, Qian Yun, additional, Zhang, Lijuan, additional, Xia, Ruyu, additional, Huang, Na, additional, Fei, Yutong, additional, Liu, Jianpin, additional, Trent, Natalie, additional, Miraglia, Mindy, additional, Dusek, Jeffrey, additional, Pasalis, Edi, additional, Khalsa, Sat B., additional, Trifunovic-König, Milena, additional, Koch, Anna, additional, Uebelacker, Lisa, additional, Tremont, Geoffrey, additional, Gillette, Lee, additional, Epstein-Lubow, Gary, additional, Strong, David, additional, Abrantes, Ana, additional, Tyrka, Audrey, additional, Tran, Tanya, additional, Gaudiano, Brandon, additional, Miller, Ivan, additional, Ullmann, Gerhild, additional, Li, Yuhua, additional, Vaidya, Sujata, additional, Marathe, Vinod, additional, Vale, Ana C., additional, Motta, Jacquelyne, additional, Donadão, Fabíola, additional, Valente, Angela C., additional, Valente, Luana C. Carvalho, additional, Ghelman, Ricardo, additional, Vesovic, Dusan, additional, Jevdic, Dragan, additional, Jevdic, Aleksandar, additional, Jevdic, Katarina, additional, Djacic, Mihael, additional, Letic, Dragica, additional, Bozic, Drago, additional, Markovic, Marija, additional, Dunjic, Slobodan, additional, Ruscuklic, Gordana, additional, Baksa, Dezire, additional, Vrca, Kenan, additional, Vincent, Ann, additional, Wahner-Roedler, Dietlind, additional, Whipple, Mary, additional, Vogelius, Maria M., additional, Friesecke, Iris, additional, Gündling, Peter W., additional, Mahapatra, Saswati, additional, Hynes, Rebecca, additional, Van Rooy, Kimberly, additional, Looker, Sherry, additional, Ghosh, Aditya, additional, Bauer, Brent, additional, Cutshall, Susanne, additional, Walach, Harald, additional, Flores, Ana Borges, additional, Ofner, Michael, additional, Kastner, Andreas, additional, Schwarzl, Gerhard, additional, Schwameder, Hermann, additional, Alexander, Nathalie, additional, Strutzenberger, Gerda, additional, Bu, Xianwei, additional, Zhang, Jianping, additional, Wang, Shang, additional, Shi, Jinfeng, additional, Hao, Yu, additional, Wu, Jun, additional, Qiu, Zeji, additional, Wang, Yuh-Hai, additional, Lou, Chi-Jung, additional, Watts, Sam, additional, Wayne, Peter, additional, Vergara-Diaz, Gloria, additional, Gow, Brian, additional, Miranda, Jose, additional, Sudarsky, Lewis, additional, Macklin, Eric, additional, Wode, Kathrin, additional, Bergqvist, Jenny, additional, Bernhardsson, Britt-Marie, additional, Nordberg, Johanna Hök, additional, Sharp, Lena, additional, Henriksson, Roger, additional, Woo, Yeonju, additional, Hyun, Min K., additional, Wu, Hao, additional, Wang, Tian-Fang, additional, Zhao, Yan, additional, Wei, Yu, additional, Tian, Lei, additional, He, Lei, additional, Wang, Xue, additional, Wu, Ruohan, additional, Han, Mei, additional, Caldwell, Patrina H. Y., additional, Liu, Shigang, additional, Zhang, Jing, additional, Liu, Jianping, additional, Chai, Qianyun, additional, Guo, Zhongning, additional, Wang, Congcong, additional, Liu, Zhijun, additional, Li, Xun, additional, Yang, I. J., additional, Lincha, V. Ruberio, additional, Ahn, S. H., additional, Lee, D. U., additional, Shin, H. M., additional, Yang, Lu, additional, Yang, N., additional, Sung, H., additional, Shin, S. M., additional, Go, H. Y., additional, Jung, H., additional, Kim, Y., additional, Park, T. Y., additional, Yap, Angela, additional, Kwan, Yu H., additional, Tan, Chuen S., additional, Ibrahim, Syed, additional, Ang, Seng B., additional, Yayi, Alfred, additional, Yoo, Jeong E., additional, Yoo, Ho R., additional, Jang, Sae B., additional, Lee, Hye L., additional, Youssef, Ala’a, additional, Ezzat, Shahira, additional, Motaal, Amira Abdel, additional, El-Askary, Hesham, additional, Yu, Xiaotong, additional, Cui, Yashan, additional, Yun, Younghee, additional, Ahn, Jin-Hyang, additional, Jang, Bo-Hyung, additional, Kim, Kyu-Seok, additional, Choi, Inhwa, additional, Glinz, Augustina, additional, ten Brink, Fadime, additional, Büssing, Arnd, additional, Gutenbrunner, Christoph, additional, Helbrecht, Bert, additional, Fang, Tiesheng, additional, Meng, Fengxion, additional, Shen, Zhiming, additional, Zhang, Ruixin, additional, Wu, Fan, additional, Li, Ming, additional, Xuan, Xinyun, additional, Shen, Xueyong, additional, Ren, Ke, additional, Berman, Brian, additional, Zheng, Zian, additional, Wan, Yuxiang, additional, Ma, Xueyan, additional, Dong, Fei, additional, Zick, Suzie, additional, Harris, Richard, additional, Bae, Go E., additional, Kwon, Jung N., additional, Lee, Hye Y., additional, Nam, Jong K., additional, Lee, Sang D., additional, Lee, Dong H., additional, Han, Ji Y., additional, Yun, Young J., additional, Lee, Ji H., additional, Park, Hye L., additional, Park, Seong H., additional, Bocci, Chiara, additional, Ivaldi, Giovanni B., additional, Vietti, Ilaria, additional, Meaglia, Ilaria, additional, Guffi, Marta, additional, Ruggiero, Rubina, additional, Gualea, Marita, additional, Longa, Emanuela, additional, Bonucci, Massimo, additional, Croke, Sarah, additional, Rodriguez, Lourdes Diaz, additional, Caracuel-Martínez, Juan C., additional, Fajardo-Rodríguez, Manuel F., additional, Ariza-García, Angélica, additional, la Fuente, Francisca García-De, additional, Arroyo-Morales, Manuel, additional, Estrems, Maria S., additional, Gómez, Vicente G., additional, Sabater, Mónica Valero, additional, Ferreri, Rosaria, additional, Bernardini, Simonetta, additional, Pulcri, Roberto, additional, Cracolici, Franco, additional, Rinaldi, Massimo, additional, Porciani, Claudio, additional, Fisher, Peter, additional, Hughes, John, additional, Mendoza, Ariadna, additional, MacPherson, Hugh, additional, Filshie, Jacqueline, additional, Di Francesco, Antonia, additional, Bernardini, Alberto, additional, Messe, Monica, additional, Primitivo, Vincenzo, additional, Iasella, Piera A., additional, Taminato, Monica, additional, Alcantara, Jaqueline Do Carmo, additional, De Oliveira, Katia R., additional, Rodrigues, Debora C. De Azevedo, additional, Mumme, Juliana R. Campana, additional, Sunakozawa, Olga K. Matsumoto, additional, Filho, Vicente Odone, additional, Goldenberg, Joshua, additional, Day, Andrew, additional, Sasagawa, Masa, additional, Ward, Lesley, additional, Cooley, Kieran, additional, Gunnarsdottir, Thora, additional, Hjaltadottir, Ingibjorg, additional, Hajimonfarednejad, Mahdie, additional, Hannan, Nicole, additional, Hellsing, Rut, additional, Andermo, Susanne, additional, Arman, Maria, additional, von Hörsten, Iris, additional, Torrielo, Patricia Vásquez, additional, Vilaró, Carmen L. Andrade, additional, Cabrera, Francisco Cerda, additional, Hui, Henny, additional, Ziea, Eric, additional, Tsui, Dora, additional, Hsieh, Joyce, additional, Lam, Christine, additional, Chan, Edith, additional, Jensen, Mark P., additional, Battalio, Samuel L., additional, Chan, Joy, additional, Edwards, Karlyn A., additional, Gertz, Kevin J., additional, Day, Melissa A., additional, Sherlin, Leslie H., additional, Ehde, Dawn M., additional, Jang, Bo-Hyoung, additional, Börner, Anja, additional, Lee, Jihong, additional, Lee, Boram, additional, Chang, Gyu T., additional, Menassa, Alejandra, additional, Motoo, Yoshiharu, additional, Müller, Jürgen, additional, Rabini, Sabine, additional, Vinson, Bettina, additional, Storr, Martin, additional, Niemeijer, Martin, additional, Hoekman, Joop, additional, Ruijssenaaars, Wied, additional, Njoku, Faith C., additional, Norheim, Arne J., additional, Okumus, Filiz, additional, and Oncu-Celik, Halime, additional

Published
2017
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68. Supercloud

Author

Shen, Zhiming, primary, Jia, Qin, additional, Sela, Gur-Eyal, additional, Song, Weijia, additional, Weatherspoon, Hakim, additional, and Van Renesse, Robbert, additional

Published
2017
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69. Follow the Sun through the Clouds

Author

Shen, Zhiming, primary, Jia, Qin, additional, Sela, Gur-Eyal, additional, Rainero, Ben, additional, Song, Weijia, additional, van Renesse, Robbert, additional, and Weatherspoon, Hakim, additional

Published
2016
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73. Economics of a supercloud

Author

Kash, Ian, primary, Jia, Qin, additional, Shen, Zhiming, additional, Song, Weijia, additional, van Renesse, Robbert, additional, and Weatherspoon, Hakim, additional

Published
2016
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74. (Solid + liquid) phase diagram for (indomethacin + nicotinamide)-methanol or methanol/ethyl acetate mixture and solubility behavior of 1:1 (indomethacin + nicotinamide) co-crystal at T=(298.15 and 313.15) K

Author

Sun, Xiaowei, primary, Yin, Qiuxiang, additional, Ding, Suping, additional, Shen, Zhiming, additional, Bao, Ying, additional, Gong, Junbo, additional, Hou, Baohong, additional, Hao, Hongxun, additional, Wang, Yongli, additional, Wang, Jingkang, additional, and Xie, Chuang, additional

Published
2015
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76. Solid–Liquid Phase Equilibrium and Ternary Phase Diagrams of Ibuprofen–Nicotinamide Cocrystals in Ethanol and Ethanol/Water Mixtures at (298.15 and 313.15) K

Author

Sun, Xiaowei, primary, Yin, Qiuxiang, additional, Ding, Suping, additional, Shen, Zhiming, additional, Bao, Ying, additional, Gong, Junbo, additional, Hou, Baohong, additional, Hao, Hongxun, additional, Wang, Yongli, additional, Wang, Jingkang, additional, and Xie, Chuang, additional

Published
2015
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77. Supercloud

Author

Jia, Qin, primary, Shen, Zhiming, additional, Song, Weijia, additional, van Renesse, Robbert, additional, and Weatherspoon, Hakim, additional

Published
2015
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79. Manifold based Semi supervised Feature Selection for Hyperspectral Data

Author

何明一 He Mingyi, 李旭 Li Xu, 申志明 Shen Zhiming, and 魏峰 Wei Feng

Subjects
Computer science, business.industry, law, Hyperspectral imaging, Feature selection, Pattern recognition, Artificial intelligence, business, Manifold (fluid mechanics), Atomic and Molecular Physics, and Optics, law.invention
Published
2014

87. CloudScale

Author

Shen, Zhiming, primary, Subbiah, Sethuraman, additional, Gu, Xiaohui, additional, and Wilkes, John, additional

Published
2011
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88. Optimizing Hopfield Neural Network for Spectral Mixture Unmixing on GPU Platform.

Author

Mei, Shaohui, He, Mingyi, and Shen, Zhiming

Abstract

The Hopfield neural network (HNN) has been demonstrated to be an effective tool for the spectral mixture unmixing of hyperspectral images. However, it is extremely time consuming for such per-pixel algorithm to be utilized in real-world applications. In this letter, the implementation of a multichannel structure of HNN (named as MHNN) on a graphics processing unit (GPU) platform is proposed. According to the unmixing procedure of MHNN, three levels of parallelism, including thread, block, and stream, are designed to explore the peak computing capacity of a GPU device. In addition, constant and texture memories are utilized to further improve its computational performance. Experiments on both synthetic and real hyperspectral images demonstrated that the proposed GPU-based implementation works on the peak computing ability of a GPU device and obtains several hundred times of acceleration versus the CPU-based implementation while its unmixing performance remains unchanged. [ABSTRACT FROM PUBLISHER]

Published
2014
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89. Jump-start cloud: efficient deployment framework for large-scale cloud applications Jump-start cloud: efficient deployment framework for large-scale cloud applications.

Author

Wu, Xiaoxin, Shen, Zhiming, Wu, Ryan, and Lin, Yunfeng

Subjects
CLOUD computing, QUALITY of service, MATHEMATICAL models, APPLICATION software, BANDWIDTHS, VIRTUAL machine systems, COMPUTER networks
Abstract

SUMMARY Reducing the time that a user has to occupy resources for completing cloud tasks can improve cloud efficiency and lower user cost. Such a time, called cloud time, consists of cloud deployment time and application running time. In this work, we design Jump-start cloud, under which an efficient cloud deployment scheme is proposed for minimizing cloud time. It is especially beneficial to minimize cloud time for clouds serving multimedia applications, as they occupy much more significant cloud resources, such as disk I/O and networking bandwidth and computational costs in processing or transcoding multimedia contents. In particular, we have implemented virtual machine cloning based on disk image sharing for fast virtual machine and application deployment. For applications with heavy disk visits, the post-deployment QoS may suffer from image sharing, and consequently, application running time will increase. To solve this problem, different image distribution schemes have been designed. We test Jump-start cloud through a Hadoop-based benchmark and MapReduce applications. Experiment studies show that our design saves application installation time and, meanwhile, keeps application running time reasonably low, thus makes cloud time shorter. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2012
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91. Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex.

Author

Hao S, Zhu X, Huang Z, Yang Q, Liu H, Wu Y, Zhan Y, Dong Y, Li C, Wang H, Haasdijk E, Wu Z, Li S, Yan H, Zhu L, Guo S, Wang Z, Ye A, Lin Y, Cui L, Tan X, Liu H, Wang M, Chen J, Zhong Y, Du W, Wang G, Lai T, Cao M, Yang T, Xu Y, Li L, Yu Q, Zhuang Z, Xia Y, Lei Y, An Y, Cheng M, Zhao Y, Han L, Yuan Y, Song X, Song Y, Gu L, Liu C, Lin X, Wang R, Wang Z, Wang Y, Li S, Li H, Song J, Chen M, Zhou W, Yuan N, Sun S, Wang S, Chen Y, Zheng M, Fang J, Zhang R, Zhang S, Chai Q, Liu J, Wei W, He J, Zhou H, Sun Y, Liu Z, Liu C, Yao J, Liang Z, Xu X, Poo M, Li C, De Zeeuw CI, Shen Z, Liu Z, Liu L, Liu S, Sun Y, and Liu C

Subjects
Animals, Male, Mice, Interneurons metabolism, Magnetic Resonance Imaging, Purkinje Cells metabolism, Receptors, Ionotropic Glutamate genetics, Receptors, Ionotropic Glutamate metabolism, Single-Cell Analysis, Species Specificity, Atlases as Topic, Callithrix anatomy & histology, Callithrix genetics, Cerebellar Cortex metabolism, Cerebellar Cortex ultrastructure, Macaca anatomy & histology, Macaca genetics, Receptors, Glutamate metabolism, Receptors, Glutamate genetics, Transcriptome, Connectome
Abstract

The molecular and cellular organization of the primate cerebellum remains poorly characterized. We obtained single-cell spatial transcriptomic atlases of macaque, marmoset, and mouse cerebella and identified primate-specific cell subtypes, including Purkinje cells and molecular-layer interneurons, that show different expression of the glutamate ionotropic receptor Delta type subunit 2 ( GRID2 ) gene. Distinct gene expression profiles were found in anterior, posterior, and vestibular regions in all species, whereas region-selective gene expression was predominantly observed in the granular layer of primates and in the Purkinje layer of mice. Gene expression gradients in the cerebellar cortex matched well with functional connectivity gradients revealed with awake functional magnetic resonance imaging, with more lobule-specific differences between primates and mice than between two primate species. These comprehensive atlases and comparative analyses provide the basis for understanding cerebellar evolution and function.

Published
2024
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92. Unveiling the landscape of pathomics in personalized immunotherapy for lung cancer: a bibliometric analysis.

Author

Yuan L, Shen Z, Shan Y, Zhu J, Wang Q, Lu Y, and Shi H

Abstract

Background: Pathomics has emerged as a promising biomarker that could facilitate personalized immunotherapy in lung cancer. It is essential to elucidate the global research trends and emerging prospects in this domain., Methods: The annual distribution, journals, authors, countries, institutions, and keywords of articles published between 2018 and 2023 were visualized and analyzed using CiteSpace and other bibliometric tools., Results: A total of 109 relevant articles or reviews were included, demonstrating an overall upward trend; The terms "deep learning", "tumor microenvironment", "biomarkers", "image analysis", "immunotherapy", and "survival prediction", etc. are hot keywords in this field., Conclusion: In future research endeavors, advanced methodologies involving artificial intelligence and pathomics will be deployed for the digital analysis of tumor tissues and the tumor microenvironment in lung cancer patients, leveraging histopathological tissue sections. Through the integration of comprehensive multi-omics data, this strategy aims to enhance the depth of assessment, characterization, and understanding of the tumor microenvironment, thereby elucidating a broader spectrum of tumor features. Consequently, the development of a multimodal fusion model will ensue, enabling precise evaluation of personalized immunotherapy efficacy and prognosis for lung cancer patients, potentially establishing a pivotal frontier in this domain of investigation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Yuan, Shen, Shan, Zhu, Wang, Lu and Shi.)

Published
2024
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93. p53 Promotes Ferroptosis in Macrophages Treated with Fe 3 O 4 Nanoparticles.

Author

Wu C, Shen Z, Lu Y, Sun F, and Shi H

Subjects
Fluorescent Dyes, Glutathione metabolism, Glutathione Disulfide metabolism, Macrophages metabolism, Phospholipid Hydroperoxide Glutathione Peroxidase, Reactive Oxygen Species metabolism, Receptors, Transferrin metabolism, Tissue Distribution, Tumor Suppressor Protein p53 genetics, Tumor Suppressor Protein p53 metabolism, Ferroptosis, Nanoparticles
Abstract

Fe 3 O 4 nanoparticles are the most widely used magnetic nanoparticles in the biomedicine field. The biodistribution of most nanoparticles in vivo is determined by the capture of macrophages; however, the effects of nanoparticles on macrophages remain poorly understood. Here, we demonstrated that Fe 3 O 4 nanoparticles could reduce macrophage viability after 48 h of treatment and induce a shift in macrophage polarization toward the M1 phenotype; RNA sequencing revealed the activation of the ferroptosis pathway and p53 upregulation compared to the control group. The expression in p53, xCT, glutathione peroxidase 4 (GPX4), and transferrin receptor (TFR) in macrophages was similar to that in erastin-induced ferroptosis in macrophages, and the ultrastructural morphology of mitochondria was consistent with that of erastin-treated cells. We used DCFH-DA to estimate the intracellular reactive oxygen species content in Fe 3 O 4 nanoparticles treated with Ana-1 and JC-1 fluorescent probes to detect the mitochondrial membrane potential change; both showed to be time-dependent. Fer-1 inhibited the reduction of the glutathione/oxidized glutathione (GSH/GSSG) ratio and inhibited intracellular oxidative stress states; therefore, Fe 3 O 4 nanoparticles induced ferroptosis in macrophages. Finally, we used pifithrin-α hydrobromide (PFT) as a p53 inhibitor to verify whether the high expression of p53 is involved in mediating this process. After PFT treatment, the live/dead cell rate, TFR, p53 expression, and GPX4 consumption were inhibited and mitigated the GSH/GSSG ratio reduction as well. This indicates that p53 may contribute to Fe 3 O 4 nanoparticle-induced ferroptosis of macrophages. We provide a theoretical basis for the molecular mechanisms of ferroptosis in macrophages and the biotoxicity in vivo induced by Fe 3 O 4 nanoparticles.

Published
2022
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94. WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis.

Author

Qin Y, Zhou Y, Shen Z, Xu B, Chen M, Li Y, Chen M, Behrens A, Zhou J, Qi X, Meng W, Wang Y, and Gao F

Subjects
Animals, Cell Cycle Proteins genetics, Centrosome metabolism, Male, Meiosis genetics, Meiosis physiology, Metaphase genetics, Metaphase physiology, Mice, Mice, Knockout, Microtubule-Associated Proteins genetics, Nerve Tissue Proteins genetics, Protein Binding, Spermatocytes cytology, Spermatocytes metabolism, Spermatogenesis genetics, Spermatogenesis physiology, Cell Cycle Proteins metabolism, Microtubule-Associated Proteins metabolism, Nerve Tissue Proteins metabolism, Spindle Apparatus metabolism
Abstract

WDR62 is the second most common genetic alteration associated with microcephaly. It has been shown that Wdr62 is required for germ cell meiosis initiation in mice, and the majority of male germ cells are lost in the meiotic defect of first wave spermatogenesis in Wdr62 mutants. Strikingly, in this study, we found that the initiation of meiosis following spermatogenesis was not affected and the germ cells were gradually repopulated at later developmental stages. However, most germ cells were arrested at metaphase of meiosis I and no mature sperm were detected in epididymides. Further, this study demonstrated that metaphase I arrest of Wdr62 -deficient spermatocytes was caused by asymmetric distribution of the centrosome and aberrant spindle assembly. Also, mechanistic studies demonstrated that WDR62 interacts with centrosome-associated protein CEP170, and deletion of Wdr62 causes downregulation of the CEP170 protein, which in turn leads to the aberrant spindle assembly. In summary, this study indicates that the meiosis of first wave spermatogenesis and the following spermatogenesis started from spermatogonium is probably regulated by different mechanisms. We also demonstrated a new function of WDR62 in germ cell meiosis, through its interaction with CEP170., Competing Interests: Competing interestsThe authors declare no competing or financial interests., (© 2019. Published by The Company of Biologists Ltd.)

Published
2019
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95. [Effects of 37 centigrade volume resuscitation on coagulation function and blood lactic acid in neonates with septic shock].

Author

Zhong X, Zhong M, Luo K, Shen Z, Liao H, Wang H, and Tu Q

Subjects
Blood Coagulation Tests, Humans, Infant, Newborn, Saline Solution therapeutic use, Temperature, Treatment Outcome, Blood Coagulation physiology, Fluid Therapy methods, Lactic Acid blood, Shock, Septic therapy
Abstract

Objective: To investigate the effect of volume resuscitation with normal saline (NS) at 37 centigrade on the coagulation function and microcirculation of neonates with septic shock., Methods: Children with septic shock admitted to neonatal intensive care unit (NICU) of the First Affiliated Hospital of Gannan Medical University were enrolled. Twenty-four newborns with septic shock were divided into two groups by random number table method (12 in each group), and were resuscitated with 10 mL/kg at 25 centigrade NS and 37 centigrade NS respectively on the basis of routine treatment. Factor II, V, VII, VIII, IX, X, and prothrombin time (PT), thrombin Time (TT), fibrinogen (FIB), activated partial thromboplastin time (APTT), D-Dimer (DD), lactic acid (Lac) were detected before treatment and 6 hours and 12 hours after treatment., Results: The levels of coagulation factors II, V, VII, VIII, IX, X were not significantly changed before and after treatment in the two groups, and there was no significant difference between the two groups. After treatment, PT and APTT in both groups were gradually shortened, DD and Lac were gradually decreased, FIB were gradually increased, while TT had no significant change. Among them, PT, APTT, DD and Lac at 6 hours after treatment in 37 centigradeNS group were significantly lower than those before treatment [PT (s): 14.07±1.02 vs. 17.08±1.54, APTT (s): 54.83±12.39 vs. 69.17±16.36, DD (mg/L): 2.40±0.63 vs. 4.18±0.88, Lac (mmol/L): 2.84±0.82 vs. 5.98±1.17, all P < 0.05]; DD and Lac at 6 hours after treatment in 25 centigrade NS group were significantly lower than those before treatment [DD (mg/L): 3.13±0.84 vs. 4.16±1.04, Lac (mmol/L): 4.83±0.64 vs. 5.69±0.74, both P < 0.05], and PT at 12 hours after treatment was significantly shorter than that before treatment (s: 14.63±1.14 vs. 16.48±1.61, P < 0.01); FIB in both 25 centigrade NS group and 37 centigrade NS group at 12 hours after treatment were significantly higher than those before treatment (g/L: 2.83±0.83 vs. 1.58±0.43, 2.87±0.87 vs. 1.47±0.41, both P < 0.01), but TT had no significant change. The comparison between groups showed that PT, DD and Lac in the 37 centigrade NS group were significantly lower than those in the 25 centigrade NS group at 6 hours after treatment [PT (s): 14.07±1.02 vs. 15.69±1.21, DD (mg/L): 2.40±0.63 vs. 3.13±0.84, Lac (mmol/L): 2.84±0.82 vs. 4.83±0.64, all P < 0.05]; at 12 hours after treatment, PT, APTT and DD in the 37 centigrade NS group were significantly lower than those in the 25 centigrade NS group [PT (s): 13.26±0.91 vs. 14.63±1.14, APTT (s): 37.08±10.43 vs. 54.75±14.96, DD (mg/L): 1.20±0.59 vs. 2.06±0.69, all P < 0.01], and FIB was significantly higher than that in the 25 centigrade NS group (g/L: 2.87±0.87 vs. 2.83±0.83, P < 0.05)., Conclusions: Volume resuscitation at 37 centigrade can improve the coagulation function and microcirculation of newborns with septic shock.

Published
2018
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