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474 results on '"Ropele S"'

51. Tracking of magnetite labeled nanoparticles in the rat brain using MRI

Author

Martínez Vera, N.P., Schmidt, R., Langer, K., Zlatev, I., Wronski, R., Auer, E., Havas, D., Windisch, M., Briesen, H. von, Wagner, S., Stab, J., Deutsch, M., Pietrzik, C., Fazekas, F., Ropele, S., and Publica

Subjects
Drug Research and Development, Image Processing, Science, Materials Science, Biomedical Engineering, Bioengineering, Neuroimaging, Research and Analysis Methods, Rodents, Diagnostic Radiology, Model Organisms, Diagnostic Medicine, Medicine and Health Sciences, Animals, Nanotechnology, Humans, Magnetite Nanoparticles, Materials by Attribute, Serum Albumin, Nanomaterials, Mammals, Pharmacology, Drug Carriers, Phantoms, Imaging, Radiology and Imaging, Organisms, Biology and Life Sciences, Brain, Biological Transport, Animal Models, Magnetic Resonance Imaging, Rats, Neurology, Vertebrates, Physical Sciences, Signal Processing, Engineering and Technology, Feasibility Studies, Medicine, Female, Molecular Neuroscience, Clinical Medicine, Research Article, Biotechnology, Neuroscience
Abstract

This study was performed to explore the feasibility of tracing nanoparticles for drug transport in the healthy rat brain with a clinical MRI scanner. Phantom studies were performed to assess the R-1 (= 1/T-1) relaxivity of different magnetically labeled nanoparticle (MLNP) formulations that were based on biodegradable human serum albumin and that were labeled with magnetite of different size. In vivo MRI measurements in 26 rats were done at 3T to study the effect and dynamics of MLNP uptake in the rat brain and body. In the brain, MLNPs induced T-1 changes were quantitatively assessed by T-1 relaxation time mapping in vivo and compared to post-mortem results from fluorescence imaging. Following intravenous injection of MLNPs, a visible MLNP uptake was seen in the liver and spleen while no visual effect was seen in the brain. However a histogram analysis of T-1 changes in the brain demonstrated global and diffuse presence of MLNPs. The magnitude of these T-1 changes scaled with post-mortem fluorescence intensity. This study demonstrates the feasibility of tracking even small amounts of magnetite labeled NPs with a sensitive histogram technique in the brain of a living rodent.

Published
2014

52. Relating functional reorganisation in multiple sclerosis to clinical measures in a multi-centre study

Author

Wegner, C., Agosta, F., Barkhof, F., Beckmann, C., Ciccarelli, O., Nicola De Stefano, Fazekas, F., Filippi, M., Gass, A., Hirsch, J., Johansen-Berg, H., Kappos, L., Korteweg, T., Mancini, L., Manfredonia, F., Marino, S., Miller, Dh, Montalban, X., Palace, J., Polman, C., Rocca, M., Ropele, S., Rovira, A., Smith, S., Thompson, A., Thornton, J., Yousry, T., Matthews, P., Wegner, C, Agosta, F, Barkhof, F, Beckmann, C, Ciccarelli, O, De Stefano, N, Fazekas, F, Filippi, M, Gass, A, Hirsch, J, Johansen Berg, H, Kappos, L, Korteweg, T, Mancini, L, Manfredonia, F, Marino, S, Miller, Dh, Montalban, H, Palace, J, Polman, C, Rocca, Ma, Ropele, S, Rovira, A, Smith, S, Thompson, T, Thornton, J, Yousry, T, and Matthews, P.

Published
2006

53. A Semiautomatic Method for Multiple Sclerosis Lesion Segmentation on Dual-Echo MR Imaging: Application in a Multicenter Context

Author

Storelli, L., primary, Pagani, E., additional, Rocca, M.A., additional, Horsfield, M.A., additional, Gallo, A., additional, Bisecco, A., additional, Battaglini, M., additional, De Stefano, N., additional, Vrenken, H., additional, Thomas, D.L., additional, Mancini, L., additional, Ropele, S., additional, Enzinger, C., additional, Preziosa, P., additional, and Filippi, M., additional

Published
2016
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55. Diffusion changes predict cognitive and functional outcome: The LADIS study

Author

Jokinen, H., Schmidt, R., Ropele, S., Fazekas, F., Gouw, A.A., Barkhof, F., Scheltens, P., Madureira, S., Verdelho, A., Ferro, J.M., Wallin, A., Poggesi, A., Inzitari, D., Pantoni, L., Erkinjuntti, T., Neurology, Radiology and nuclear medicine, and NCA - neurodegeneration

Published
2013

60. Short-term adaptation to a simple motor task: a physiological process preserved in multiple sclerosis

Author

Ciccarelli, O., Manfredonia, F., Thornton, Js, Agosta, F., Barkhof, F., Beckmann, C., DE STEFANO, N., Enzinger, C., Fazekas, F., Filippi, M., Gass, A., Hirsch, J. G., JOHANSEN BERG, H., Kappos, L., Korteweg, T., Manson, S. C., Marino, Silvia, Matthews, P. M., Montalban, X., Palace, J., Polman, C., Rocca, M., Ropele, S., Rovira, A., Wegner, C., Friston, K., Thompson, A., and Yoursy, T.

Published
2009

63. Relating functional changes during hand movement to clinical parameters in patients with Multiple Sclerosis in a Multi-Centre fMRI Study

Author

Wegner, C, Filippi, M., Barkhof, F., Beckmann, C., Ciccarelli, O., DE STEFANO, N., Enzinger, C., Fazekas, F., Agosta, F., Gass, A., Hirsch, J., JOHANSEN BERG, H., Kappos, L., Korteweg, T., Polman, C., Mancini, L., Manfredonia, F., Marino, Silvia, Miller, D. H., Montalban, X., Palace, J., Rocca, M., Ropele, S., Rovira, A., Smith, S., Thompson, A., Thornton, J., and Matthews, T. YOUSRY AND P.

Published
2008

64. Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition

Author

Manson, Sc, Wegner, C., Filippi, M., Barkhof, F., Beckmann, C., Ciccarelli, O., DE STEFANO, N., Enzinger, C., Fazekas, F., Agosta, F., Gass, A., Hirsch, J., JOHANSEN BERG, H., Kappos, L., Korteweg, T., Polman, C., Mancini, L., Manfredonia, F., Marino, Silvia, Miller, D. H., Montalban, X., Palace, J., Rocca, M., Ropele, S., Rovira, A., Smith, S., Thompson, A., Thornton, J., Yousry, T., and Matthews, J. A. FRANK AND P.

Published
2008

65. Reproducibility of fMRI in the clinical setting: Implications for trial designs

Author

Bosnell, R, Wegner, C, Kincses, Zt, Korteweg, T, Agosta, F, Ciccarelli, O, DE STEFANO, N, Gass, A, Hirsch, J, JOHANSEN BERG, H, Kappos, L, Barkhof, F, Mancini, L, Manfredonia, F, Marino, Silvia, Miller, D. H., Montalban, X, Palace, J, Rocca, M, Enzinger, C, Ropele, S, Rovira, A, Smith, S, Thompson, A, Thornton, J, Yousry, T, Filippi, M, and Matthews, Pm

Published
2008

67. Factors associated with progression of brain atrophy during ageing: 6 year follow-up from the Austrian stroke prevention study

Author

Enzinger, C., Fazekas, F., Matthews, P. M., Ropele, S., Schmidt, H., Stephen Smith, and Schmidt, R.

Abstract

Neuroimaging techniques are increasingly used to study mechanisms leading to cognitive impairment. In particular, brain atrophy has been proposed as a surrogate marker of dementia. However, little is known regarding confounding factors which might modulate the evolution of brain atrophy during ageing. We therefore determined the rate of atrophy over 6 years for 201 participants (F/M=96/105; 59.8±5.9 yrs) in the Austrian Stroke Prevention Study and probed the impact of baseline variables on its progression. The mean annual brain volume change was -0.40±0.29%. The rate of brain atrophy was significantly higher in subjects of greater age and those with higher HbA1c, higher body-mass-index, high alcohol intake, severe white matter hyperintensities, and in APOEε4-carriers. Multivariate analysis suggested that baseline brain volume, HbA1c and the extent of white matter hyperintensities explain a major proportion of variance in the rates of brain atrophy. These results indicate that neurologically asymptomatic elderly experience continuing brain volume loss, which appears to accelerate with age. HbA1c was identified as a risk factor for a greater rate of brain atrophy. Clustering of factors associated with the so-called "metabolic syndrome" in subjects with high HbA1c suggests a link between this syndrome and late-life brain tissue loss. Together, this underscores the need to control for confounding factors in future Clinical trials and indicates possible new directions for intervention.

Published
2006

78. Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study.

Author

Tillema, J. M., Hulst, H. E., Rocca, M. A., Vrenken, H., Steenwijk, M. D., Damjanovic, D., Enzinger, C., Ropele, S., Tedeschi, G., Gallo, A., Ciccarelli, O., Rovira, A., Montalban, X., de Stefano, N., Stromillo, M. L., Filippi, M., and Barkhof, F.

Subjects
MULTIPLE sclerosis, COGNITION disorders, COGNITION, BRAIN imaging, NEUROPSYCHOLOGICAL tests
Abstract

Objectives: The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing–remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. Methods: T1-weighted isotropic brain scans were collected at 3T from seven European centers in 60 RRMS patients and 65 healthy controls (HCs). Patients underwent clinical and neuropsychological examinations. Cortical thickness (CTh) measures were calculated using FreeSurfer (failing in four) and both lobar and vertex-based general linear model (GLM) analyses were compared between study groups. Results: Twenty (36%) MS patients were classified as CI. Mean global CTh was smaller in RRMS patients compared to HCs (left 2.43 vs. 2.53 mm, right 2.44 vs. 2.54 mm, p < 0.001). Multivariate GLM regional analysis showed significantly more temporal thinning in CI compared to CP patients. Verbal memory scores correlated to regional cortical thinning in the insula whereas visual memory scores correlated to parietal thinning. Conclusions: This multicenter study showed mild global cortical thinning in RRMS. The extent of thinning is less pronounced than previously reported. Only subtle regional differences between CI and CP patients were observed, some of which related to specific cognitive domains. [ABSTRACT FROM AUTHOR]

Published
2016
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79. Combined analysis of global and compartmental brain volume changes in early multiple sclerosis in clinical practice.

Author

Pichler, A., Khalil, M., Langkammer, C., Pinter, D., Bachmaier, G., Ropele, S., Fuchs, S., Enzinger, C., and Fazekas, F.

Subjects
DISEASE progression, MAGNETIC resonance imaging, MULTIPLE sclerosis research, CEREBRAL atrophy, NEUROLOGY, RADIOLOGY
Abstract

Background: The extent and clinical significance of brain volume changes in different phases of multiple sclerosis (MS) is still under discussion. Objective: To determine the rate of global and compartmental brain volume changes in patients with a clinically-isolated syndrome (CIS) compared to patients with definite MS, by long-term follow-up and as a predictor of conversion to MS in a routine clinical setting. Methods: We investigated 120 patients (63 CIS and 57 MS) at baseline and after a mean follow-up period of 43 months, including detailed clinical examination and 3-Tesla magnetic resonance imaging (MRI). Our imaging analyses comprised the normalized brain volume (NBV), cortical grey matter (cGMV) and white matter (WMV) volumes using SIENA/X, the percentage of brain volume change (PBVC) using SIENA and the change in the volume of the thalami (TV) and basal ganglia (BGV). We also determined the amount and change of T2-lesion load (T2-LL). Results: At baseline, all the brain volume metrics, except cGMV, were significantly lower; and the T2-LL was significantly higher, in patients with MS rather than CIS. During the follow-up, only the PBVC was higher in MS (p = 0.008) and this difference was driven by converters from CIS to MS. Quartiles of PBVC did not allow us to predict conversion to MS, but were associated with the degree of disability. Conclusions: PBVC is the most sensitive marker of progressing atrophy and a higher PBVC was generally associated with more active disease; however, it did not serve to predict the course of MS on an individual basis, in this study. [ABSTRACT FROM AUTHOR]

Published
2016
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80. CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome

Author

Khalil, M, primary, Enzinger, C, additional, Langkammer, C, additional, Ropele, S, additional, Mader, A, additional, Trentini, A, additional, Vane, MLG, additional, Wallner-Blazek, M, additional, Bachmaier, G, additional, Archelos, J-J, additional, Koel-Simmelink, MJA, additional, Blankenstein, MA, additional, Fuchs, S, additional, Fazekas, F, additional, and Teunissen, CE, additional

Published
2012
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86. Lesion probability mapping to explain clinical deficits and cognitive performance in multiple sclerosis

Author

Kincses, ZT, primary, Ropele, S, additional, Jenkinson, M, additional, Khalil, M, additional, Petrovic, K, additional, Loitfelder, M, additional, Langkammer, C, additional, Aspeck, E, additional, Wallner-Blazek, M, additional, Fuchs, S, additional, Jehna, M, additional, Schmidt, R, additional, Vécsei, L, additional, Fazekas, F, additional, and Enzinger, C, additional

Published
2010
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99. CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome.

Author

Khalil, M, Enzinger, C, Langkammer, C, Ropele, S, Mader, A, Trentini, A, Vane, MLG, Wallner-Blazek, M, Bachmaier, G, Archelos, J-J, Koel-Simmelink, MJA, Blankenstein, MA, Fuchs, S, Fazekas, F, and Teunissen, CE

Subjects
CEREBROSPINAL fluid, BIOMARKERS, AXONAL transport, MAGNETIC resonance imaging, CYTOPLASMIC filaments
Abstract

The article presents a study which assessed the reflection and prediction for cerebrospinal spinal fluid (CSF) biomarkers for axonal damage. The study performed baseline magnetic resonance imaging (MRI) to patients with clinically isolated syndrome (CIS). The result of the study shows that there was an increase neurofilament levels in CIS.

Published
2013
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100. Differences and similarities in the evolution of morphologic brain abnormalities between paediatric and adult-onset multiple sclerosis.

Author

Pichler, A, Enzinger, C, Fuchs, S, Plecko-Startinig, B, Gruber-Sedlmayr, U, Linortner, P, Langkammer, C, Khalil, M, Ebner, F, Ropele, S, and Fazekas, F

Subjects
BRAIN abnormalities, MULTIPLE sclerosis in children, DISEASE progression, COMPARATIVE studies, MYELIN sheath diseases
Abstract

The article presents a study which compares the evolution of morphologic brain abnormalities between paediatric (p)and adult-onset multiple sclerosis (aMS). The study the examined the differences and similarities in the evolution of the T2- and T1-lesion load (LL), annualised brain volume change (aBVC), and the black hole ratio (BHR), between 21 pMS and aMS patients. Results showed higher compensatory capacity in pMS than aMS based on the observation of the disease evolution.

Published
2013
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