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51. Biosimilar Candidate CT-P42 in Diabetic Macular Edema: 24-Week Results from a Randomized, Active-Controlled, Phase III Study

Author

Wolf, Sebastian, Stanga, Paulo-Eduardo, Veselovsky, Milan, Veith, Miroslav, Papp, Andras, Mange, Shobhana, Kanta Mondal, Lakshmi, Romanczak, Dominika, Janco, Ladislav, Chauhan, Rohan, Romanowska-Dixon, Bożena, Eremina, Alena, Zavgorodnya, Nataliya, Dusova, Jaroslava, Sagong, Min, Kim, Sunghyun, Ahn, Keumyoung, Kim, Suyoung, Bae, Youngmin, Lee, Sangmi, Kang, Hyejin, and Brown, David M.

Published
2024
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52. High prevalence of thrombophilic risk factors in patients with central retinal artery occlusion

Author

Radosław Dziedzic, Lech Zaręba, Teresa Iwaniec, Agnieszka Kubicka-Trząska, Bożena Romanowska-Dixon, Stanisława Bazan-Socha, and Jerzy Dropiński

Subjects
Central retinal artery occlusion, CRAO, Thrombophilia, Thrombosis, Risk factors, Intima-media thickness, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Abstract Introduction Central retinal artery occlusion (CRAO) is a common cause of blindness and visual morbidity. In the majority of cases, it is related to thrombotic embolism. Nevertheless, the role of inherited or acquired thrombophilic risk factors in CRAO pathogenesis has not been comprehensively studied. Methods In 126 CRAO patients (66 [52.4%] men, median age 55 [range: 18–80] years) and 107 matched controls (56 [52.3%] men, median age 53 [range: 34–78] years) we evaluated classical atherosclerotic risk factors, including serum lipid profile and glucose level, analyzed intima-media complex thickness (IMT) of external carotid arteries, and performed transthoracic echocardiography. Furthermore, we established the prevalence of inherited and acquired thrombophilic risk factors, such as factor V Leiden (FVL) and prothrombin 20210 G/A genetic variants, plasma activity of factor (F) VIII, protein C and antithrombin activity, and free protein S levels. We also assessed the presence of antiphospholipid antibodies (APLA) and evaluated blood homocysteine in all enrolled subjects. Additionally, we estimated the occurrence of Val34Leu polymorphism of the A subunit of coagulation factor XIII (FXIII-A) in both groups as a potential thrombosis-protecting factor. Results Among traditional atherosclerotic risk components, obesity/overweight and hypercholesterolemia were the most common in the CRAO group and occurred in 103 (81.7%) and 85 (67.5%) patients, respectively. CRAO patients also had elevated IMT and altered echocardiographic parameters, indicating diastolic cardiac dysfunction. In thrombophilia investigations, at least one laboratory risk factor occurred in 72.2% (n = 91) of CRAO patients, with APLA as the most frequent, detected in 38.1% (n = 48) of them (almost seven times more frequent than in controls, p

Published
2023
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53. Stability selection enhances feature selection and enables accurate prediction of gestational age using only five DNA methylation sites

Author

Kristine L. Haftorn, Julia Romanowska, Yunsung Lee, Christian M. Page, Per M. Magnus, Siri E. Håberg, Jon Bohlin, Astanand Jugessur, and William R. P. Denault

Subjects
DNA methylation, Epigenetics, Gestational age, Illumina MethylationEPIC BeadChip, Epigenetic clock, Stability selection, Medicine, Genetics, QH426-470
Abstract

Abstract Background DNA methylation (DNAm) is robustly associated with chronological age in children and adults, and gestational age (GA) in newborns. This property has enabled the development of several epigenetic clocks that can accurately predict chronological age and GA. However, the lack of overlap in predictive CpGs across different epigenetic clocks remains elusive. Our main aim was therefore to identify and characterize CpGs that are stably predictive of GA. Results We applied a statistical approach called ‘stability selection’ to DNAm data from 2138 newborns in the Norwegian Mother, Father, and Child Cohort study. Stability selection combines subsampling with variable selection to restrict the number of false discoveries in the set of selected variables. Twenty-four CpGs were identified as being stably predictive of GA. Intriguingly, only up to 10% of the CpGs in previous GA clocks were found to be stably selected. Based on these results, we used generalized additive model regression to develop a new GA clock consisting of only five CpGs, which showed a similar predictive performance as previous GA clocks (R 2 = 0.674, median absolute deviation = 4.4 days). These CpGs were in or near genes and regulatory regions involved in immune responses, metabolism, and developmental processes. Furthermore, accounting for nonlinear associations improved prediction performance in preterm newborns. Conclusion We present a methodological framework for feature selection that is broadly applicable to any trait that can be predicted from DNAm data. We demonstrate its utility by identifying CpGs that are highly predictive of GA and present a new and highly performant GA clock based on only five CpGs that is more amenable to a clinical setting.

Published
2023
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54. Ophthalmic applicator displacement as a method of treating large diffuse uveal melanomas

Author

Anna Markiewicz, Konrad Skórkiewicz, Agata Bogdał, Dominik Medoń, Mirella Świder, Elżbieta Korab-Chrzanowska, Joanna Kowal, Magdalena Dębicka-Kumela, and Bożena Romanowska-Dixon

Subjects
uveal melanoma, applicator displacement, plaque displacement, brachytherapy, enucleation, ocular melanoma, diffuse uveal melanoma, ophthalmic applicator, Medicine
Published
2023
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55. Defect-engineered graphene-on-silicon-carbide platform for magnetic field sensing at greatly elevated temperatures

Author

Tymoteusz Ciuk, Roman Kozłowski, Agata Romanowska, Andrzej Zagojski, Karolina Piętak-Jurczak, Beata Stańczyk, Krystyna Przyborowska, Dariusz Czołak, and Paweł Kamiński

Subjects
Graphene, Epitaxy, CVD, Ion implantation, Defect levels, HRPITS, Chemistry, QD1-999
Abstract

High-temperature electrical properties of p-type hydrogen-intercalated quasi-free-standing epitaxial Chemical Vapor Deposition graphene on semi-insulating vanadium-compensated on-axis 6H-SiC(0001) and high-purity on-axis 4H-SiC(0001) originate from the double-carrier system of spontaneous-polarization-induced holes in graphene and thermally-activated electrons in the substrate. In this study, we pre-epitaxially modify SiC by implanting hydrogen (H+) and helium (He+) ions with energies ranging from 20 keV to 50 keV to reconstruct its post-epitaxial defect structure and suppress the thermally-developed electron channel. Through a combination of dark current measurements and High-Resolution Photo-Induced Transient Spectroscopy between 300 K and 700 K, we monitor the impact of ion bombardment on the transport properties of SiC and reveal activation energies of the individual deep-level defects. We find that the ion implantation has a negligible effect on 6H-SiC. Yet in 4H-SiC, it shifts the Fermi level from ∼600 meV to ∼800 meV below the minimum of the conduction band and reduces the electron concentration by two orders of magnitude. Specifically, it eliminates deep electron traps related to silicon vacancies in the charge state (2-/-) occupying the h and k sites of the 4H-SiC lattice. Finally, we directly implement the protocol of deep-level defect engineering in the technology of amorphous-aluminum-oxide-passivated Hall effect sensors and introduce a mature sensory platform with record-linear current-mode sensitivity of approximately 80 V/AT with -0.03-%/K stability in a broad temperature range between 300 K and 770 K, and likely far beyond 770 K.

Published
2023
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57. The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome?

Author

Julia Romanowska, Haakon E. Nustad, Christian M. Page, William R. P. Denault, Yunsung Lee, Maria C. Magnus, Kristine L. Haftorn, Miriam Gjerdevik, Boris Novakovic, Richard Saffery, Håkon K. Gjessing, Robert Lyle, Per Magnus, Siri E. Håberg, and Astanand Jugessur

Subjects
Epigenetics, Assisted reproductive technology (ART), The Norwegian Mother, Father and Child Cohort Study (MoBa), DNA methylation, Epigenome-wide association study, Medicine, Genetics, QH426-470
Abstract

Abstract Background Assisted reproductive technologies (ART) may perturb DNA methylation (DNAm) in early embryonic development. Although a handful of epigenome-wide association studies of ART have been published, none have investigated CpGs on the X chromosome. To bridge this knowledge gap, we leveraged one of the largest collections of mother–father–newborn trios of ART and non-ART (natural) conceptions to date to investigate sex-specific DNAm differences on the X chromosome. The discovery cohort consisted of 982 ART and 963 non-ART trios from the Norwegian Mother, Father, and Child Cohort Study (MoBa). To verify our results from the MoBa cohort, we used an external cohort of 149 ART and 58 non-ART neonates from the Australian ‘Clinical review of the Health of adults conceived following Assisted Reproductive Technologies’ (CHART) study. The Illumina EPIC array was used to measure DNAm in both datasets. In the MoBa cohort, we performed a set of X-chromosome-wide association studies (‘XWASs’ hereafter) to search for sex-specific DNAm differences between ART and non-ART newborns. We tested several models to investigate the influence of various confounders, including parental DNAm. We also searched for differentially methylated regions (DMRs) and regions of co-methylation flanking the most significant CpGs. Additionally, we ran an analogous model to our main model on the external CHART dataset. Results In the MoBa cohort, we found more differentially methylated CpGs and DMRs in girls than boys. Most of the associations persisted after controlling for parental DNAm and other confounders. Many of the significant CpGs and DMRs were in gene-promoter regions, and several of the genes linked to these CpGs are expressed in tissues relevant for both ART and sex (testis, placenta, and fallopian tube). We found no support for parental DNAm-dependent features as an explanation for the observed associations in the newborns. The most significant CpG in the boys-only analysis was in UBE2DNL, which is expressed in testes but with unknown function. The most significant CpGs in the girls-only analysis were in EIF2S3 and AMOT. These three loci also displayed differential DNAm in the CHART cohort. Conclusions Genes that co-localized with the significant CpGs and DMRs associated with ART are implicated in several key biological processes (e.g., neurodevelopment) and disorders (e.g., intellectual disability and autism). These connections are particularly compelling in light of previous findings indicating that neurodevelopmental outcomes differ in ART-conceived children compared to those naturally conceived.

Published
2023
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59. Virtual Reality as a Teaching Resource Which Reinforces Emotions in the Teaching Process

Author

Slósarz, Luba, Jurczyk-Romanowska, Ewa, Rosinczuk, Joanna, and Kazimierska-Zajac, Magdalena

Abstract

In the educational context, virtual reality (VR) can be defined as a set of diverse hardware and software technologies that can be used to provide the experience of immersion in the learning process. This study aimed to investigate the connection between VR and emotions that can motivate students to be more active in the didactic process. A group of 99 participants was involved and watched three short individual VR sessions using Oculus glasses. We monitored participants' moods (using the SUPIN/PANAS questionnaire) and we also gauged their self-esteem (SES questionnaire). Participation in VR sessions increases the intensity in learners' emotions. The increase or decrease in emotions depends on whether they are positive or negative. First and foremost, we observed changes in the intensity of positive emotions which, after VR intervention, increased significantly in relation to the initial measurement, compared with the intensity of negative emotions during the post-test. The results show that VR significantly modifies learners' emotions, contributing to the reinforcement of positive emotional states, and in the case of those with low self-esteem, it also decreases negative emotional states. In conclusion, VR can be used as a didactic tool to facilitate the teaching-learning process at various levels. It makes it possible not only to practice skills in simulated, safer conditions and illustrate presented material, but also to make the didactic process more attractive, thereby influencing learners' emotions positively.

Published
2022
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60. Ocular Manifestation in Systemic Sclerosis—A Literature Review

Author

Katarzyna Paczwa, Magdalena Rerych, Katarzyna Romanowska-Próchnicka, Radosław Różycki, and Joanna Gołębiewska

Subjects
systemic sclerosis, ocular manifestation, scleroderma, ocular involvement, retina, dry eye syndrome, Science
Abstract

Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease that affects more than 2 million people worldwide. It manifests through vasculopathy, an abnormal immunological response, and fibrosis leading to dysfunction of the multiple organs. The disease is categorized into two subtypes: limited cutaneous SSc and diffuse cutaneous SSc. Scleroderma can affect vital organs with respiratory, cardiac, renal, ocular, and dermatological complications. The ocular manifestations of the disease can occur in the anterior and posterior segments of the eye. Changes in the anterior segment related to the disease include eyelid skin remodeling, dry eye syndrome, and conjunctival abnormalities. The disease’s impact on the posterior segment of the eye mostly causes pathologies in the retinal microcirculatory system and abnormalities in the optic nerve. This review provides detailed insights into ocular complications associated with scleroderma.

Published
2024
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61. Circulating Anti-Endothelial Cell Antibodies in Patients with Geographic Atrophy Related to Dry Age-Related Macular Degeneration

Author

Katarzyna Żuber-Łaskawiec, Joanna Wilańska, Izabella Karska-Basta, Weronika Pociej-Marciak, Bożena Romanowska-Dixon, Marek Sanak, and Agnieszka Kubicka-Trząska

Subjects
anti-retinal antibodies, anti-endothelial cell antibodies, age-related macular degeneration, geographic atrophy, indirect immunofluorescence, Medicine (General), R5-920
Abstract

Background and Objectives: Age-related macular degeneration (AMD) is one of the leading causes of central vision loss among elderly patients, and its dry form accounts for the majority of cases. Although several causes and mechanisms for the development and progression of AMD have previously been identified, the pathogenesis of this complex disease is still not entirely understood. As inflammation and immune system involvement are strongly suggested to play a central role in promoting the degenerative process and stimulating the onset of complications, we aimed to analyze the frequency of serum anti-retinal (ARAs) and anti-endothelial cell antibodies (AECAs) in patients with dry AMD and to determine their relationship with the clinical features of the disease, notably the area of geographic atrophy (GA). Materials and Methods: This study included 41 patients with advanced-stage dry AMD and 50 healthy controls without AMD, matched for gender and age. ARAs were detected by indirect immunofluorescence using monkey retina as an antigen substrate, and the presence of AECAs was determined using cultivated human umbilical vein endothelial cells and primate skeletal muscle. Results: ARAs were detected in 36 (87.8%) AMD patients (titers ranged from 1:20 to 1:320) and in 16 (39.0%) (titers ranged from 1:10 to 1:40) controls (p = 0.0000). Twenty of the forty-one patients (48.8%) were positive for AECAs, while in the control group, AECAs were present only in five sera (10.0%). The titers of AECAs in AMD patients ranged from 1:100 to 1:1000, and in the control group, the AECA titers were 1:100 (p = 0.0001). There were no significant correlations between the presence of AECAs and disease activity. Conclusions: This study demonstrates a higher prevalence of circulating AECAs in patients with dry AMD; however, no correlation was found between the serum levels of these autoantibodies and the area of GA.

Published
2024
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62. Managing Undernutrition in Pediatric Oncology: A Consensus Statement Developed Using the Delphi Method by the Polish Society for Clinical Nutrition of Children and the Polish Society of Pediatric Oncology and Hematology

Author

Agnieszka Budka-Chrzęszczyk, Agnieszka Szlagatys-Sidorkiewicz, Ewa Bień, Ninela Irga-Jaworska, Anna Borkowska, Małgorzata Anna Krawczyk, Katarzyna Popińska, Hanna Romanowska, Ewa Toporowska-Kowalska, Magdalena Świder, Jan Styczyński, Tomasz Szczepański, and Janusz Książyk

Subjects
childhood cancer, nutrition, nutritional support, Nutrition. Foods and food supply, TX341-641
Abstract

“Managing Undernutrition in Pediatric Oncology” is a collaborative consensus statement of the Polish Society for Clinical Nutrition of Children and the Polish Society of Pediatric Oncology and Hematology. The early identification and accurate management of malnutrition in children receiving anticancer treatment are crucial components to integrate into comprehensive medical care. Given the scarcity of high-quality literature on this topic, a consensus statement process was chosen over other approaches, such as guidelines, to provide comprehensive recommendations. Nevertheless, an extensive literature review using the PubMed database was conducted. The following terms, namely pediatric, childhood, cancer, pediatric oncology, malnutrition, undernutrition, refeeding syndrome, nutritional support, and nutrition, were used. The consensus was reached through the Delphi method. Comprehensive recommendations aim to identify malnutrition early in children with cancer and optimize nutritional interventions in this group. The statement underscores the importance of baseline and ongoing assessments of nutritional status and the identification of the risk factors for malnutrition development, and it presents tools that can be used to achieve these goals. This consensus statement establishes a standardized approach to nutritional support, aiming to optimize outcomes in pediatric cancer patients.

Published
2024
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63. Evaluation of Arsenic and Cobalt Levels in Pediatric Patients Receiving Long-Term Parenteral Nutrition

Author

Hanna Romanowska, Aleksandra Wilk, Mikołaj Danko, Anna Borkowska, Katarzyna Popińska, Marta Sibilska, Joanna Żydak, Wojciech Marciniak, Agnieszka Szlagatys-Sidorkiewicz, and Janusz Książyk

Subjects
arsenic, cobalt, trace elements, parenteral nutrition, children, Nutrition. Foods and food supply, TX341-641
Abstract

This study continues the research in which we determined the concentration of aluminum in children receiving long-term parenteral nutrition (LPN). Since our results were interesting, we decided to assay arsenic (As) and cobalt (Co) in the collected material, which, like aluminum, constitute contamination in the mixtures used in parenteral nutrition. Excesses of these trace elements in the human body are highly toxic, and deficiencies, particularly in the case of Co, can lead to various complications. The aim of this study was to determine the impact of LPN in children on their serum levels of As and Co, as well as the excretion of these elements in urine, and to compare them with a control group of healthy children. The study group consisted of 83 children receiving home parenteral nutrition from two Polish centers, while the control group included 121 healthy children. In both groups, the levels of As and Co in serum and urine were measured. The elemental compositions of the samples were determined using inductively coupled plasma mass spectrometry (ICP-MS). It was demonstrated that the children receiving LPN did not have increased As exposure compared to the controls. Greater exposure compared to the control group was shown for Co. In conclusion, children receiving LPN are not exposed to As, and even though the concentrations of Co in serum and urine were higher in the LPN group than in the healthy controls, neither trace element poses a health threat to children requiring LPN.

Published
2024
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64. Red Blood Cell Adenylate Energetics Is Related to Endothelial and Microvascular Function in Long COVID

Author

Marzena Romanowska-Kocejko, Agata Jędrzejewska, Alicja Braczko, Klaudia Stawarska, Oliwia Król, Marika Frańczak, Gabriela Harasim, Ryszard T. Smoleński, Marcin Hellmann, and Barbara Kutryb-Zając

Subjects
long COVID, red blood cells, nucleotides, microcirculation, endothelium, Biology (General), QH301-705.5
Abstract

Adenine nucleotides play a critical role in maintaining essential functions of red blood cells (RBCs), including energy metabolism, redox status, shape fluctuations and RBC-dependent endothelial and microvascular functions. Recently, it has been shown that infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) might lead to morphological and metabolic alterations in erythrocytes in both mild and severe cases of coronavirus disease (COVID-19). However, little is known about the effects of COVID-19 on the nucleotide energetics of RBCs nor about the potential contribution of nucleotide metabolism to the long COVID syndrome. This study aimed to analyze the levels of adenine nucleotides in RBCs isolated from patients 12 weeks after mild SARS-CoV-2 infection who suffered from long COVID symptoms and to relate them with the endothelial and microvascular function parameters as well as the rate of peripheral tissue oxygen supply. Although the absolute quantities of adenine nucleotides in RBCs were rather slightly changed in long COVID individuals, many parameters related to the endothelial and microcirculatory function showed significant correlations with RBC adenosine triphosphate (ATP) and total adenine nucleotide (TAN) concentration. A particularly strong relationship was observed between ATP in RBCs and the serum ratio of arginine to asymmetric dimethylarginine—an indicator of endothelial function. Consistently, a positive correlation was also observed between the ATP/ADP ratio and diminished reactive hyperemic response in long COVID patients, assessed by the flow-mediated skin fluorescence (FMSF) technique, which reflected decreased vascular nitric oxide bioavailability. In addition, we have shown that patients after COVID-19 have significantly impaired ischemic response parameters (IR max and IR index), examined by FMSF, which revealed diminished residual bioavailability of oxygen in epidermal keratinocytes after brachial artery occlusion. These ischemic response parameters revealed a strong positive correlation with the RBC ATP/ADP ratio, confirming a key role of RBC bioenergetics in peripheral tissue oxygen supply. Taken together, the outcomes of this study indicate that dysregulation of metabolic processes in erythrocytes with the co-occurring endothelial and microvascular dysfunction is associated with diminished intracellular oxygen delivery, which may partly explain long COVID-specific symptoms such as physical impairment and fatigue.

Published
2024
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65. Diagnostic Challenges in Inflammatory Choroidal Neovascularization

Author

Izabella Karska-Basta, Weronika Pociej-Marciak, Katarzyna Żuber-Łaskawiec, Anna Markiewicz, Michał Chrząszcz, Bożena Romanowska-Dixon, and Agnieszka Kubicka-Trząska

Subjects
uveitis, inflammatory choroidal neovascularization, multimodal imaging, fluorescein angiography, indocyanine green angiography, optical coherence tomography, Medicine (General), R5-920
Abstract

Inflammation plays a key role in the induction of choroidal neovascularization (CNV). Inflammatory choroidal neovascularization (iCNV) is a severe but uncommon complication of both infectious and non-infectious uveitides. It is hypothesized that its pathogenesis is similar to that of wet age-related macular degeneration (AMD), and involves hypoxia as well as the release of vascular endothelial growth factor, stromal cell-derived factor 1-alpha, and other mediators. Inflammatory CNV develops when inflammation or infection directly involves the retinal pigment epithelium (RPE)–Bruch’s membrane complex. Inflammation itself can compromise perfusion, generating a gradient of retinal–choroidal hypoxia that additionally promotes the formation of choroidal neovascularization in the course of uveitis. The development of choroidal neovascularization may be a complication, especially in conditions such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and presumed ocular histoplasmosis syndrome. Although the majority of iCNV cases are well defined and appear as the “classic” type (type 2 lesion) on fluorescein angiography, the diagnosis of iCNV is challenging due to difficulties in differentiating between inflammatory choroiditis lesions and choroidal neovascularization. Modern multimodal imaging, particularly the recently introduced technology of optical coherence tomography (OCT) and OCT angiography (noninvasive and rapid imaging modalities), can reveal additional features that aid the diagnosis of iCNV. However, more studies are needed to establish their role in the diagnosis and evaluation of iCNV activity.

Published
2024
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67. Nucleated red blood cells explain most of the association between DNA methylation and gestational age

Author

Kristine L. Haftorn, William R. P. Denault, Yunsung Lee, Christian M. Page, Julia Romanowska, Robert Lyle, Øyvind E. Næss, Dana Kristjansson, Per M. Magnus, Siri E. Håberg, Jon Bohlin, and Astanand Jugessur

Subjects
Biology (General), QH301-705.5
Abstract

CpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as being partly responsible for this association.

Published
2023
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68. Microstructure and oxidation resistance of Pd+Zr and Pd+Hf co-doped aluminide coatings deposited on Mar-M247 nickel superalloy

Author

Romanowska J. and Zagula-Yavorska M.

Subjects
nickel superalloys, aluminide coatings, hafnium, zirconium, oxidation, Mining engineering. Metallurgy, TN1-997
Abstract

Pd+Zr and Pd+Hf co-doped aluminide coatings were deposited on the nickel superalloy Mar-M247 by palladium electroplating followed by zirconization-aluminization or hafnization-aluminization processes. Both coatings consisted of two zones, the outer and the interdiffusion zone consisting of the β-(Ni,Pd)Al phase. Hafnium and zirconium formed inclusions deposited at the edge of the zones and near the surface (only in the Zr+Pd modified coating). The oxidation resistance of the aluminide coating co-doped with Pd+Zr was significantly better than the one co-doped with Pd+Hf. The hafnium content in the Pd+Hf co-doped coating could exceed the limit.

Published
2023
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69. Activity of Patents in Fuel Cells and Hydrogen Production in the Context of Passenger Car Fleet in the V4 Countries

Author

Pangsy-Kania Sylwia, Romanowska Aleksandra, Wierzbicka Katarzyna, and Kania Katarzyna

Subjects
patents, zero-emission mobility, fuel cells, hydrogen production, v4, passenger car fleet, History of scholarship and learning. The humanities, AZ20-999
Abstract

The hydrogen market in the world today is capable ovule and empirical evidence on activity of patents in fuel cells and hydrogen production is limited so far. Patent applications in zero-emission mobility in the aspect of fuel cells include: DAFC/DMFC&DMFC, PEMFC, SOFC, AFC, PAFC. As for the patents relating to the hydrogen production, they concern low carbon, electrolysis and inorganic. The purpose of the study was to investigate certain aspects of the activity of patents in fuel cells and hydrogen production in the context of passenger car fleet in the Visegrad group (V4) countries and to explore the relationship between patent registrations and GDP per capita in V4. The research area relates to the answer to the question of whether a country’s involvement in zero-emission patent activity (patents in fuel cells and hydrogen production) could contribute to the renewal of the country’s passenger car fleet. The theses were formulated as follows: 1) activity of patents in fuel cells and hydrogen production in the V4 countries doesn’t depend on the car fleet in these countries, 2) the level of GDP per capita in the V4 countries is not followed by the number of patents registrations in hydrogen technology, 3) the highest patent activity in fuel cells and hydrogen production doesn’t mean that the car fleet in these country will be zero-emission in coming years. The method used in this article is a comparative analysis, but also the relationships between patent registrations, GDP per capita and passenger car fleet in V4 are considered

Published
2022
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70. Automatic air volume control system for ventilation of two patients using a single ventilator: a large animal model study

Author

Krzysztof Zieliński, Barbara Lisowska, Katarzyna Siewruk, Maria Sady, Karolina Ferenc, Maciej Barwijuk, Jarosław Olszewski, Krzysztof Anusz, Artur Jabłoński, Magdalena Gajewska, Piotr Okrzeja, Marcin Michnikowski, Dorota G. Pijanowska, Krzysztof Pluta, Elżbieta Remiszewska, Marek Darowski, Romuald Zabielski, Adam Liebert, Katarzyna Kramek-Romanowska, Anna Stecka, Maciej Kozarski, Raman Pasledni, Zdzisław Gajewski, and Piotr Ładyżyński

Subjects
Medicine, Science
Abstract

Abstract The COVID-19 pandemic outbreak led to a global ventilator shortage. Hence, various strategies for using a single ventilator to support multiple patients have been considered. A device called Ventil previously validated for independent lung ventilation was used in this study to evaluate its usability for shared ventilation. We performed experiments with a total number of 16 animals. Eight pairs of pigs were ventilated by a ventilator or anesthetic machine and by Ventil for up to 27 h. In one experiment, 200 ml of saline was introduced to one subject’s lungs to reduce their compliance. The experiments were analyzed in terms of arterial blood gases and respiratory parameters. In addition to the animal study, we performed a series of laboratory experiments with artificial lungs (ALs). The resistance and compliance of one AL (affected) were altered, while the tidal volume (TV) and peak pressure (Ppeak) in the second (unaffected) AL were analyzed. In addition, to assess the risk of transmission of pathogens between AL respiratory tracts, laboratory tests were performed using phantoms of virus particles. The physiological level of analyzed parameters in ventilated animals was maintained, except for CO2 tension, for which a permissive hypercapnia was indicated. Experiments did not lead to injuries in the animal’s lungs except for one subject, as indicated by CT scan analysis. In laboratory experiments, changes in TV and Ppeak in the unaffected AL were less than 11%, except for 2 cases where the TV change was 20%. No cross-contamination was found in simulations of pathogen transmission. We conclude that ventilation using Ventil can be considered safe in patients undergoing deep sedation without spontaneous breathing efforts.

Published
2022
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74. Vision Zero in Poland

Author

Jamroz, Kazimierz, primary, Romanowska, Aleksandra, additional, Michalski, Lech, additional, and Żukowska, Joanna, additional

Published
2022
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75. Improving Biorefinery Sustainability and Profitability by Cultivating Aquatic Plants on Ozonized Distillery Effluents

Author

Piotr Dziugan, Zdzisława Romanowska-Duda, Krzysztof Piotrowski, Weronika Cieciura-Włoch, Hubert Antolak, Krzysztof Śmigielski, Michał Binczarski, Izabela Witońska, and Jaroslaw Domanski

Subjects
biorefinery, post-fermentation effluent, ozone treatment, lemnaceae, Biotechnology, TP248.13-248.65
Abstract

Industrial production of biogas offers a way to manage distillery leachate. The waste is usually subjected to anaerobic digestion for producing biogas. However, the effluent from anaerobic processes has high chemical oxygen demand (COD) and is harmful to the environment. An effective method of lowering COD is ozonation. Effluent from biogas plants after ozonation has the potential for use in breeding grounds for plants of the Lemnaceae family. Thus, they can provide a valuable additional source of biomass for the production of bioethanol. Lemna minor L. and Spirodela polyrhiza cultures were grown in media with the addition of 2.5% PFE, which had been treated by ozonation for between 6 and 50 min. Using ozonated effluent was an effective cultivation technique in all variants. The analyzed parameters were plant growth, chlorophyll index, fresh plant weight and photosynthetic traits (net photosynthesis, stomatal conductance, transpiration and concentration of intercellular CO2). The best growth of Lemna minor L. was observed in the media with PFE treated for 12 min. Similar effects were obtained for S. polyrhiza, with ozone treatment for 12 and 25 min. The results show the potential of using ozone-treated post-fermentation leachate as a supplement in culture media.

Published
2022

76. Erratum to: Searches for long-lived charged particles in pp collisions at s $$ \sqrt{\textrm{s}} $$ = 7 and 8 TeV

Author

The CMS collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, V. Knünz, M. Krammer, I. Krätschmer, D. Liko, I. Mikulec, D. Rabady, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, W. Treberer-Treberspurg, W. Waltenberger, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Alderweireldt, M. Bansal, S. Bansal, T. Cornelis, E. A. De Wolf, X. Janssen, A. Knutsson, S. Luyckx, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, A. Kalogeropoulos, J. Keaveney, M. Maes, A. Olbrechts, S. Tavernier, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, B. Clerbaux, G. De Lentdecker, L. Favart, A. P. R. Gay, T. Hreus, A. Léonard, P. E. Marage, A. Mohammadi, L. Perniè, T. Reis, T. Seva, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wang, V. Adler, K. Beernaert, L. Benucci, A. Cimmino, S. Costantini, S. Dildick, G. Garcia, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, M. Sigamani, N. Strobbe, F. Thyssen, M. Tytgat, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, C. Beluffi, G. Bruno, R. Castello, A. Caudron, L. Ceard, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, J. Hollar, P. Jez, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, A. Popov, M. Selvaggi, J. M. Vizan Garcia, N. Beliy, T. Caebergs, E. Daubie, G. H. Hammad, G. A. Alves, M. Correa Martins Junior, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, J. Chinellato, A. Custódio, E. M. Da Costa, D. De Jesus Damiao, C. De Oliveira Martins, S. Fonseca De Souza, H. Malbouisson, M. Malek, D. Matos Figueiredo, L. Mundim, H. Nogima, W. L. Prado Da Silva, A. Santoro, A. Sznajder, E. J. Tonelli Manganote, A. Vilela Pereira, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, G. Sultanov, M. Vutova, A. Dimitrov, R. Hadjiiska, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, X. Wang, Z. Wang, H. Xiao, M. Xu, C. Asawatangtrakuldee, Y. Ban, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, D. Wang, L. Zhang, W. Zou, C. Avila, C. A. Carrillo Montoya, J. P. Gomez, B. Gomez Moreno, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, D. Mekterovic, S. Morovic, L. Tikvica, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, A. Ellithi Kamel, M. A. Mahmoud, A. Mahrous, A. Radi, M. Kadastik, M. Müntel, M. Murumaa, M. Raidal, L. Rebane, A. Tiko, P. Eerola, G. Fedi, M. Voutilainen, J. Härkönen, V. Karimäki, R. Kinnunen, M. J. Kortelainen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, T. Peltola, E. Tuominen, J. Tuominiemi, E. Tuovinen, L. Wendland, A. Korpela, T. Tuuva, M. Besancon, S. Choudhury, F. Couderc, M. Dejardin, D. Denegri, B. Fabbro, J. L. Faure, F. Ferri, S. Ganjour, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, E. Locci, J. Malcles, L. Millischer, A. Nayak, J. Rander, A. Rosowsky, M. Titov, S. Baffioni, F. Beaudette, L. Benhabib, L. Bianchini, M. Bluj, P. Busson, C. Charlot, N. Daci, T. Dahms, M. Dalchenko, L. Dobrzynski, A. Florent, R. Granier de Cassagnac, M. Haguenauer, P. Miné, C. Mironov, I. N. Naranjo, M. Nguyen, C. Ochando, P. Paganini, D. Sabes, R. Salerno, Y. Sirois, C. Veelken, A. Zabi, J.-L. Agram, J. Andrea, D. Bloch, D. Bodin, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, F. Drouhin, J.-C. Fontaine, D. Gelé, U. Goerlach, C. Goetzmann, P. Juillot, A.-C. Le Bihan, P. Van Hove, S. Gadrat, S. Beauceron, N. Beaupere, G. Boudoul, S. Brochet, J. Chasserat, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, B. Ille, T. Kurca, M. Lethuillier, L. Mirabito, S. Perries, L. Sgandurra, V. Sordini, Y. Tschudi, M. Vander Donckt, P. Verdier, S. Viret, Z. Tsamalaidze, C. Autermann, S. Beranek, B. Calpas, M. Edelhoff, L. Feld, N. Heracleous, O. Hindrichs, K. Klein, A. Ostapchuk, A. Perieanu, F. Raupach, J. Sammet, S. Schael, D. Sprenger, H. Weber, B. Wittmer, V. Zhukov, M. Ata, J. Caudron, E. Dietz-Laursonn, D. Duchardt, M. Erdmann, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, D. Klingebiel, P. Kreuzer, M. Merschmeyer, A. Meyer, M. Olschewski, K. Padeken, P. Papacz, H. Pieta, H. Reithler, S. A. Schmitz, L. Sonnenschein, J. Steggemann, D. Teyssier, S. Thüer, M. Weber, V. Cherepanov, Y. Erdogan, G. Flügge, H. Geenen, M. Geisler, W. Haj Ahmad, F. Hoehle, B. Kargoll, T. Kress, Y. Kuessel, J. Lingemann, A. Nowack, I. M. Nugent, L. Perchalla, O. Pooth, A. Stahl, M. Aldaya Martin, I. Asin, N. Bartosik, J. Behr, W. Behrenhoff, U. Behrens, M. Bergholz, A. Bethani, K. Borras, A. Burgmeier, A. Cakir, L. Calligaris, A. Campbell, F. Costanza, C. Diez Pardos, S. Dooling, T. Dorland, G. Eckerlin, D. Eckstein, G. Flucke, A. Geiser, I. Glushkov, P. Gunnellini, S. Habib, J. Hauk, G. Hellwig, H. Jung, M. Kasemann, P. Katsas, C. Kleinwort, H. Kluge, M. Krämer, D. Krücker, E. Kuznetsova, W. Lange, J. Leonard, K. Lipka, W. Lohmann, B. Lutz, R. Mankel, I. Marfin, I.-A. Melzer-Pellmann, A. B. Meyer, J. Mnich, A. Mussgiller, S. Naumann-Emme, O. Novgorodova, F. Nowak, J. Olzem, H. Perrey, A. Petrukhin, D. Pitzl, R. Placakyte, A. Raspereza, P. M. Ribeiro Cipriano, C. Riedl, E. Ron, M. Ö. Sahin, J. Salfeld-Nebgen, R. Schmidt, T. Schoerner-Sadenius, N. Sen, M. Stein, R. Walsh, C. Wissing, V. Blobel, H. Enderle, J. Erfle, U. Gebbert, M. Görner, M. Gosselink, J. Haller, K. Heine, R. S. Höing, G. Kaussen, H. Kirschenmann, R. Klanner, R. Kogler, J. Lange, I. Marchesini, T. Peiffer, N. Pietsch, D. Rathjens, C. Sander, H. Schettler, P. Schleper, E. Schlieckau, A. Schmidt, M. Schröder, T. Schum, M. Seidel, J. Sibille, V. Sola, H. Stadie, G. Steinbrück, J. Thomsen, D. Troendle, L. Vanelderen, C. Barth, C. Baus, J. Berger, C. Böser, T. Chwalek, W. De Boer, A. Descroix, A. Dierlamm, M. Feindt, M. Guthoff, C. Hackstein, F. Hartmann, T. Hauth, M. Heinrich, H. Held, K. H. Hoffmann, U. Husemann, I. Katkov, J. R. Komaragiri, A. Kornmayer, P. Lobelle Pardo, D. Martschei, S. Mueller, Th. Müller, M. Niegel, A. Nürnberg, O. Oberst, J. Ott, G. Quast, K. Rabbertz, F. Ratnikov, S. Röcker, F.-P. Schilling, G. Schott, H. J. Simonis, F. M. Stober, R. Ulrich, J. Wagner-Kuhr, S. Wayand, T. Weiler, M. Zeise, G. Anagnostou, G. Daskalakis, T. Geralis, S. Kesisoglou, A. Kyriakis, D. Loukas, A. Markou, C. Markou, E. Ntomari, L. Gouskos, T. J. Mertzimekis, A. Panagiotou, N. Saoulidou, E. Stiliaris, X. Aslanoglou, I. Evangelou, G. Flouris, C. Foudas, P. Kokkas, N. Manthos, I. Papadopoulos, E. Paradas, G. Bencze, C. Hajdu, P. Hidas, D. Horvath, B. Radics, F. Sikler, V. Veszpremi, G. Vesztergombi, A. J. Zsigmond, N. Beni, S. Czellar, J. Molnar, J. Palinkas, Z. Szillasi, J. Karancsi, P. Raics, Z. L. Trocsanyi, B. Ujvari, S. B. Beri, V. Bhatnagar, N. Dhingra, R. Gupta, M. Kaur, M. Z. Mehta, M. Mittal, N. Nishu, L. K. Saini, A. Sharma, J. B. Singh, Ashok Kumar, Arun Kumar, S. Ahuja, A. Bhardwaj, B. C. Choudhary, S. Malhotra, M. Naimuddin, K. Ranjan, P. Saxena, V. Sharma, R. K. Shivpuri, S. Banerjee, S. Bhattacharya, K. Chatterjee, S. Dutta, B. Gomber, Sa. Jain, Sh. Jain, R. Khurana, A. Modak, S. Mukherjee, D. Roy, S. Sarkar, M. Sharan, A. Abdulsalam, D. Dutta, S. Kailas, V. Kumar, A. K. Mohanty, L. M. Pant, P. Shukla, A. Topkar, T. Aziz, R. M. Chatterjee, S. Ganguly, S. Ghosh, M. Guchait, A. Gurtu, G. Kole, S. Kumar, M. Maity, G. Majumder, K. Mazumdar, G. B. Mohanty, B. Parida, K. Sudhakar, N. Wickramage, S. Dugad, H. Arfaei, H. Bakhshiansohi, S. M. Etesami, A. Fahim, H. Hesari, A. Jafari, M. Khakzad, M. Mohammadi Najafabadi, S. Paktinat Mehdiabadi, B. Safarzadeh, M. Zeinali, M. Grunewald, M. Abbrescia, L. Barbone, C. Calabria, S. S. Chhibra, A. Colaleo, D. Creanza, N. De Filippis, M. De Palma, L. Fiore, G. Iaselli, G. Maggi, M. Maggi, B. Marangelli, S. My, S. Nuzzo, N. Pacifico, A. Pompili, G. Pugliese, G. Selvaggi, L. Silvestris, G. Singh, R. Venditti, P. Verwilligen, G. Zito, G. Abbiendi, A. C. Benvenuti, D. Bonacorsi, S. Braibant-Giacomelli, L. Brigliadori, R. Campanini, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, C. Grandi, L. Guiducci, S. Marcellini, G. Masetti, M. Meneghelli, A. Montanari, F. L. Navarria, F. Odorici, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. P. Siroli, N. Tosi, R. Travaglini, S. Albergo, M. Chiorboli, S. Costa, F. Giordano, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, S. Frosali, E. Gallo, S. Gonzi, V. Gori, P. Lenzi, M. Meschini, S. Paoletti, G. Sguazzoni, A. Tropiano, L. Benussi, S. Bianco, D. Piccolo, P. Fabbricatore, R. Musenich, S. Tosi, A. Benaglia, F. De Guio, L. Di Matteo, S. Fiorendi, S. Gennai, A. Ghezzi, P. Govoni, M. T. Lucchini, S. Malvezzi, R. A. Manzoni, A. Martelli, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, S. Ragazzi, N. Redaelli, T. Tabarelli de Fatis, S. Buontempo, N. Cavallo, A. De Cosa, F. Fabozzi, A. O. M. Iorio, L. Lista, S. Meola, M. Merola, P. Paolucci, P. Azzi, N. Bacchetta, D. Bisello, A. Branca, R. Carlin, P. Checchia, T. Dorigo, U. Dosselli, M. Galanti, F. Gasparini, U. Gasparini, P. Giubilato, A. Gozzelino, M. Gulmini, K. Kanishchev, S. Lacaprara, I. Lazzizzera, M. Margoni, G. Maron, A. T. Meneguzzo, J. Pazzini, N. Pozzobon, P. Ronchese, F. Simonetto, E. Torassa, M. Tosi, S. Vanini, P. Zotto, A. Zucchetta, G. Zumerle, M. Gabusi, S. P. Ratti, C. Riccardi, P. Vitulo, M. Biasini, G. M. Bilei, L. Fanò, P. Lariccia, G. Mantovani, M. Menichelli, A. Nappi, F. Romeo, A. Saha, A. Santocchia, A. Spiezia, K. Androsov, P. Azzurri, G. Bagliesi, T. Boccali, G. Broccolo, R. Castaldi, R. T. D’Agnolo, R. Dell’Orso, F. Fiori, L. Foà, A. Giassi, A. Kraan, F. Ligabue, T. Lomtadze, L. Martini, A. Messineo, F. Palla, A. Rizzi, A. T. Serban, P. Spagnolo, P. Squillacioti, R. Tenchini, G. Tonelli, A. Venturi, P. G. Verdini, C. Vernieri, L. Barone, F. Cavallari, D. Del Re, M. Diemoz, M. Grassi, E. Longo, F. Margaroli, P. Meridiani, F. Micheli, S. Nourbakhsh, G. Organtini, R. Paramatti, S. Rahatlou, L. Soffi, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, C. Biino, N. Cartiglia, S. Casasso, M. Costa, N. Demaria, C. Mariotti, S. Maselli, E. Migliore, V. Monaco, M. Musich, M. M. Obertino, G. Ortona, N. Pastrone, M. Pelliccioni, A. Potenza, A. Romero, M. Ruspa, R. Sacchi, A. Solano, A. Staiano, U. Tamponi, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, G. Della Ricca, B. Gobbo, C. La Licata, M. Marone, D. Montanino, A. Penzo, A. Schizzi, A. Zanetti, T. Y. Kim, S. K. Nam, S. Chang, D. H. Kim, G. N. Kim, J. E. Kim, D. J. Kong, Y. D. Oh, H. Park, D. C. Son, J. Y. Kim, Zero J. Kim, S. Song, S. Choi, D. Gyun, B. Hong, M. Jo, H. Kim, T. J. Kim, K. S. Lee, S. K. Park, Y. Roh, M. Choi, J. H. Kim, C. Park, I. C. Park, S. Park, G. Ryu, Y. Choi, Y. K. Choi, J. Goh, M. S. Kim, E. Kwon, B. Lee, J. Lee, S. Lee, H. Seo, I. Yu, I. Grigelionis, A. Juodagalvis, H. Castilla-Valdez, E. De La Cruz-Burelo, I. Heredia-de La Cruz, R. Lopez-Fernandez, J. Martínez-Ortega, A. Sanchez-Hernandez, L. M. Villasenor-Cendejas, S. Carrillo Moreno, F. Vazquez Valencia, H. A. Salazar Ibarguen, E. Casimiro Linares, A. Morelos Pineda, M. A. Reyes-Santos, D. Krofcheck, A. J. Bell, P. H. Butler, R. Doesburg, S. Reucroft, H. Silverwood, M. Ahmad, M. I. Asghar, J. Butt, H. R. Hoorani, S. Khalid, W. A. Khan, T. Khurshid, S. Qazi, M. A. Shah, M. Shoaib, H. Bialkowska, B. Boimska, T. Frueboes, M. Górski, M. Kazana, K. Nawrocki, K. Romanowska-Rybinska, M. Szleper, G. Wrochna, P. Zalewski, G. Brona, K. Bunkowski, M. Cwiok, W. Dominik, K. Doroba, A. Kalinowski, M. Konecki, J. Krolikowski, M. Misiura, W. Wolszczak, N. Almeida, P. Bargassa, A. David, P. Faccioli, P. G. Ferreira Parracho, M. Gallinaro, J. Rodrigues Antunes, J. Seixas, J. Varela, P. Vischia, P. Bunin, M. Gavrilenko, I. Golutvin, I. Gorbunov, A. Kamenev, V. Karjavin, V. Konoplyanikov, G. Kozlov, A. Lanev, A. Malakhov, V. Matveev, P. Moisenz, V. Palichik, V. Perelygin, S. Shmatov, N. Skatchkov, V. Smirnov, A. Zarubin, S. Evstyukhin, V. Golovtsov, Y. Ivanov, V. Kim, P. Levchenko, V. Murzin, V. Oreshkin, I. Smirnov, V. Sulimov, L. Uvarov, S. Vavilov, A. Vorobyev, An. Vorobyev, Yu. Andreev, A. Dermenev, S. Gninenko, N. Golubev, M. Kirsanov, N. Krasnikov, A. Pashenkov, D. Tlisov, A. Toropin, V. Epshteyn, M. Erofeeva, V. Gavrilov, N. Lychkovskaya, V. Popov, G. Safronov, S. Semenov, A. Spiridonov, V. Stolin, E. Vlasov, A. Zhokin, V. Andreev, M. Azarkin, I. Dremin, M. Kirakosyan, A. Leonidov, G. Mesyats, S. V. Rusakov, A. Vinogradov, A. Belyaev, E. Boos, V. Bunichev, M. Dubinin, L. Dudko, A. Ershov, A. Gribushin, V. Klyukhin, O. Kodolova, I. Lokhtin, A. Markina, S. Obraztsov, V. Savrin, A. Snigirev, I. Azhgirey, I. Bayshev, S. Bitioukov, V. Kachanov, A. Kalinin, D. Konstantinov, V. Krychkine, V. Petrov, R. Ryutin, A. Sobol, L. Tourtchanovitch, S. Troshin, N. Tyurin, A. Uzunian, A. Volkov, P. Adzic, M. Ekmedzic, D. Krpic, J. Milosevic, M. Aguilar-Benitez, J. Alcaraz Maestre, C. Battilana, E. Calvo, M. Cerrada, M. Chamizo Llatas, N. Colino, B. De La Cruz, A. Delgado Peris, D. Domínguez Vázquez, C. Fernandez Bedoya, J. P. Fernández Ramos, A. Ferrando, J. Flix, M. C. Fouz, P. Garcia-Abia, O. Gonzalez Lopez, S. Goy Lopez, J. M. Hernandez, M. I. Josa, G. Merino, E. Navarro De Martino, J. Puerta Pelayo, A. Quintario Olmeda, I. Redondo, L. Romero, J. Santaolalla, M. S. Soares, C. Willmott, C. Albajar, J. F. de Trocóniz, H. Brun, J. Cuevas, J. Fernandez Menendez, S. Folgueras, I. Gonzalez Caballero, L. Lloret Iglesias, J. Piedra Gomez, J. A. Brochero Cifuentes, I. J. Cabrillo, A. Calderon, S. H. Chuang, J. Duarte Campderros, M. Fernandez, G. Gomez, J. Gonzalez Sanchez, A. Graziano, C. Jorda, A. Lopez Virto, J. Marco, R. Marco, C. Martinez Rivero, F. Matorras, F. J. Munoz Sanchez, T. Rodrigo, A. Y. Rodríguez-Marrero, A. Ruiz-Jimeno, L. Scodellaro, I. Vila, R. Vilar Cortabitarte, D. Abbaneo, E. Auffray, G. Auzinger, M. Bachtis, P. Baillon, A. H. Ball, D. Barney, J. Bendavid, J. F. Benitez, C. Bernet, G. Bianchi, P. Bloch, A. Bocci, A. Bonato, O. Bondu, C. Botta, H. Breuker, T. Camporesi, G. Cerminara, T. Christiansen, J. A. Coarasa Perez, S. Colafranceschi, D. d’Enterria, A. Dabrowski, A. De Roeck, S. De Visscher, S. Di Guida, M. Dobson, N. Dupont-Sagorin, A. Elliott-Peisert, J. Eugster, W. Funk, G. Georgiou, M. Giffels, D. Gigi, K. Gill, D. Giordano, M. Girone, M. Giunta, F. Glege, R. Gomez-Reino Garrido, S. Gowdy, R. Guida, J. Hammer, M. Hansen, P. Harris, C. Hartl, A. Hinzmann, V. Innocente, P. Janot, E. Karavakis, K. Kousouris, K. Krajczar, P. Lecoq, Y.-J. Lee, C. Lourenço, N. Magini, M. Malberti, L. Malgeri, M. Mannelli, L. Masetti, F. Meijers, S. Mersi, E. Meschi, R. Moser, M. Mulders, P. Musella, E. Nesvold, L. Orsini, E. Palencia Cortezon, E. Perez, L. Perrozzi, A. Petrilli, A. Pfeiffer, M. Pierini, M. Pimiä, D. Piparo, M. Plagge, G. Polese, L. Quertenmont, A. Racz, W. Reece, G. Rolandi, C. Rovelli, M. Rovere, H. Sakulin, F. Santanastasio, C. Schäfer, C. Schwick, I. Segoni, S. Sekmen, P. Siegrist, P. Silva, M. Simon, P. Sphicas, D. Spiga, M. Stoye, A. Tsirou, G. I. Veres, J. R. Vlimant, H. K. Wöhri, S. D. Worm, W. D. Zeuner, W. Bertl, K. Deiters, W. Erdmann, K. Gabathuler, R. Horisberger, Q. Ingram, H. C. Kaestli, S. König, D. Kotlinski, U. Langenegger, D. Renker, T. Rohe, F. Bachmair, L. Bäni, P. Bortignon, M. A. Buchmann, B. Casal, N. Chanon, A. Deisher, G. Dissertori, M. Dittmar, M. Donegà, M. Dünser, P. Eller, K. Freudenreich, C. Grab, D. Hits, P. Lecomte, W. Lustermann, A. C. Marini, P. Martinez Ruiz del Arbol, N. Mohr, F. Moortgat, C. Nägeli, P. Nef, F. Nessi-Tedaldi, F. Pandolfi, L. Pape, F. Pauss, M. Peruzzi, F. J. Ronga, M. Rossini, L. Sala, A. K. Sanchez, A. Starodumov, B. Stieger, M. Takahashi, L. Tauscher, A. Thea, K. Theofilatos, D. Treille, C. Urscheler, R. Wallny, H. A. Weber, C. Amsler, V. Chiochia, C. Favaro, M. Ivova Rikova, B. Kilminster, B. Millan Mejias, P. Otiougova, P. Robmann, H. Snoek, S. Taroni, S. Tupputi, M. Verzetti, M. Cardaci, K. H. Chen, C. Ferro, C. M. Kuo, S. W. Li, W. Lin, Y. J. Lu, R. Volpe, S. S. Yu, P. Bartalini, P. Chang, Y. H. Chang, Y. W. Chang, Y. Chao, K. F. Chen, C. Dietz, U. Grundler, W.-S. Hou, Y. Hsiung, K. Y. Kao, Y. J. Lei, R.-S. Lu, D. Majumder, E. Petrakou, X. Shi, J. G. Shiu, Y. M. Tzeng, M. Wang, B. Asavapibhop, N. Srimanobhas, A. Adiguzel, M. N. Bakirci, S. Cerci, C. Dozen, I. Dumanoglu, E. Eskut, S. Girgis, G. Gokbulut, E. Gurpinar, I. Hos, E. E. Kangal, A. Kayis Topaksu, G. Onengut, K. Ozdemir, S. Ozturk, A. Polatoz, K. Sogut, D. Sunar Cerci, B. Tali, H. Topakli, M. Vergili, I. V. Akin, T. Aliev, B. Bilin, S. Bilmis, M. Deniz, H. Gamsizkan, A. M. Guler, G. Karapinar, K. Ocalan, A. Ozpineci, M. Serin, R. Sever, U. E. Surat, M. Yalvac, M. Zeyrek, E. Gülmez, B. Isildak, M. Kaya, O. Kaya, S. Ozkorucuklu, N. Sonmez, H. Bahtiyar, E. Barlas, K. Cankocak, Y. O. Günaydin, F. I. Vardarli, M. Yücel, L. Levchuk, P. Sorokin, J. J. Brooke, E. Clement, D. Cussans, H. Flacher, R. Frazier, J. Goldstein, M. Grimes, G. P. Heath, H. F. Heath, L. Kreczko, S. Metson, D. M. Newbold, K. Nirunpong, A. Poll, S. Senkin, V. J. Smith, T. Williams, L. Basso, K. W. Bell, C. Brew, R. M. Brown, D. J. A. Cockerill, J. A. Coughlan, K. Harder, S. Harper, J. Jackson, E. Olaiya, D. Petyt, B. C. Radburn-Smith, C. H. Shepherd-Themistocleous, I. R. Tomalin, W. J. Womersley, R. Bainbridge, O. Buchmuller, D. Burton, D. Colling, N. Cripps, M. Cutajar, P. Dauncey, G. Davies, M. Della Negra, W. Ferguson, J. Fulcher, D. Futyan, A. Gilbert, A. Guneratne Bryer, G. Hall, Z. Hatherell, J. Hays, G. Iles, M. Jarvis, G. Karapostoli, M. Kenzie, R. Lane, R. Lucas, L. Lyons, A.-M. Magnan, J. Marrouche, B. Mathias, R. Nandi, J. Nash, A. Nikitenko, J. Pela, M. Pesaresi, K. Petridis, M. Pioppi, D. M. Raymond, S. Rogerson, A. Rose, C. Seez, P. Sharp, A. Sparrow, A. Tapper, M. Vazquez Acosta, T. Virdee, S. Wakefield, N. Wardle, T. Whyntie, M. Chadwick, J. E. Cole, P. R. Hobson, A. Khan, P. Kyberd, D. Leggat, D. Leslie, W. Martin, I. D. Reid, P. Symonds, L. Teodorescu, M. Turner, J. Dittmann, K. Hatakeyama, A. Kasmi, H. Liu, T. Scarborough, O. Charaf, S. I. Cooper, C. Henderson, P. Rumerio, A. Avetisyan, T. Bose, C. Fantasia, A. Heister, P. Lawson, D. Lazic, J. Rohlf, D. Sperka, J. St. John, L. Sulak, J. Alimena, G. Christopher, D. Cutts, Z. Demiragli, A. Ferapontov, A. Garabedian, U. Heintz, G. Kukartsev, E. Laird, G. Landsberg, M. Luk, M. Narain, M. Segala, T. Sinthuprasith, T. Speer, R. Breedon, G. Breto, M. Calderon De La Barca Sanchez, S. Chauhan, M. Chertok, J. Conway, R. Conway, P. T. Cox, R. Erbacher, M. Gardner, R. Houtz, W. Ko, A. Kopecky, R. Lander, O. Mall, T. Miceli, R. Nelson, D. Pellett, F. Ricci-Tam, B. Rutherford, M. Searle, J. Smith, M. Squires, M. Tripathi, S. Wilbur, R. Yohay, D. Cline, R. Cousins, S. Erhan, P. Everaerts, C. Farrell, M. Felcini, J. Hauser, M. Ignatenko, C. Jarvis, G. Rakness, P. Schlein, E. Takasugi, P. Traczyk, V. Valuev, J. Babb, R. Clare, M. E. Dinardo, J. Ellison, J. W. Gary, G. Hanson, O. R. Long, A. Luthra, H. Nguyen, S. Paramesvaran, J. Sturdy, S. Sumowidagdo, R. Wilken, S. Wimpenny, W. Andrews, J. G. Branson, G. B. Cerati, S. Cittolin, D. Evans, A. Holzner, R. Kelley, M. Lebourgeois, J. Letts, I. Macneill, B. Mangano, S. Padhi, C. Palmer, G. Petrucciani, M. Pieri, M. Sani, S. Simon, E. Sudano, M. Tadel, Y. Tu, A. Vartak, S. Wasserbaech, F. Würthwein, A. Yagil, J. Yoo, D. Barge, R. Bellan, C. Campagnari, M. D’Alfonso, T. Danielson, K. Flowers, P. Geffert, C. George, F. Golf, J. Incandela, C. Justus, P. Kalavase, D. Kovalskyi, V. Krutelyov, S. Lowette, R. Magaña Villalba, N. Mccoll, V. Pavlunin, J. Ribnik, J. Richman, R. Rossin, D. Stuart, W. To, C. West, A. Apresyan, A. Bornheim, J. Bunn, Y. Chen, E. Di Marco, J. Duarte, D. Kcira, Y. Ma, A. Mott, H. B. Newman, C. Rogan, M. Spiropulu, V. Timciuc, J. Veverka, R. Wilkinson, S. Xie, Y. Yang, R. Y. Zhu, V. Azzolini, A. Calamba, R. Carroll, T. Ferguson, Y. Iiyama, D. W. Jang, Y. F. Liu, M. Paulini, J. Russ, H. Vogel, I. Vorobiev, J. P. Cumalat, B. R. Drell, W. T. Ford, A. Gaz, E. Luiggi Lopez, U. Nauenberg, J. G. Smith, K. Stenson, K. A. Ulmer, S. R. Wagner, J. Alexander, A. Chatterjee, N. Eggert, L. K. Gibbons, W. Hopkins, A. Khukhunaishvili, B. Kreis, N. Mirman, G. Nicolas Kaufman, J. R. Patterson, A. Ryd, E. Salvati, W. Sun, W. D. Teo, J. Thom, J. Thompson, J. Tucker, Y. Weng, L. Winstrom, P. Wittich, D. Winn, S. Abdullin, M. Albrow, J. Anderson, G. Apollinari, L. A. T. Bauerdick, A. Beretvas, J. Berryhill, P. C. Bhat, K. Burkett, J. N. Butler, V. Chetluru, H. W. K. Cheung, F. Chlebana, S. Cihangir, V. D. Elvira, I. Fisk, J. Freeman, Y. Gao, E. Gottschalk, L. Gray, D. Green, O. Gutsche, D. Hare, R. M. Harris, J. Hirschauer, B. Hooberman, S. Jindariani, M. Johnson, U. Joshi, B. Klima, S. Kunori, S. Kwan, C. Leonidopoulos, J. Linacre, D. Lincoln, R. Lipton, J. Lykken, K. Maeshima, J. M. Marraffino, V. I. Martinez Outschoorn, S. Maruyama, D. Mason, P. McBride, K. Mishra, S. Mrenna, Y. Musienko, C. Newman-Holmes, V. O’Dell, O. Prokofyev, N. Ratnikova, E. Sexton-Kennedy, S. Sharma, W. J. Spalding, L. Spiegel, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, R. Vidal, J. Whitmore, W. Wu, F. Yang, J. C. Yun, D. Acosta, P. Avery, D. Bourilkov, M. Chen, T. Cheng, S. Das, M. De Gruttola, G. P. Di Giovanni, D. Dobur, A. Drozdetskiy, R. D. Field, M. Fisher, Y. Fu, I. K. Furic, J. Hugon, B. Kim, J. Konigsberg, A. Korytov, A. Kropivnitskaya, T. Kypreos, J. F. Low, K. Matchev, P. Milenovic, G. Mitselmakher, L. Muniz, R. Remington, A. Rinkevicius, N. Skhirtladze, M. Snowball, J. Yelton, M. Zakaria, V. Gaultney, S. Hewamanage, L. M. Lebolo, S. Linn, P. Markowitz, G. Martinez, J. L. Rodriguez, T. Adams, A. Askew, J. Bochenek, J. Chen, B. Diamond, S. V. Gleyzer, J. Haas, S. Hagopian, V. Hagopian, K. F. Johnson, H. Prosper, V. Veeraraghavan, M. Weinberg, M. M. Baarmand, B. Dorney, M. Hohlmann, H. Kalakhety, F. Yumiceva, M. R. Adams, L. Apanasevich, V. E. Bazterra, R. R. Betts, I. Bucinskaite, J. Callner, R. Cavanaugh, O. Evdokimov, L. Gauthier, C. E. Gerber, D. J. Hofman, S. Khalatyan, P. Kurt, F. Lacroix, D. H. Moon, C. O’Brien, C. Silkworth, D. Strom, P. Turner, N. Varelas, U. Akgun, E. A. Albayrak, B. Bilki, W. Clarida, K. Dilsiz, F. Duru, S. Griffiths, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, C. R. Newsom, H. Ogul, Y. Onel, F. Ozok, S. Sen, P. Tan, E. Tiras, J. Wetzel, T. Yetkin, K. Yi, B. A. Barnett, B. Blumenfeld, S. Bolognesi, D. Fehling, G. Giurgiu, A. V. Gritsan, Z. J. Guo, G. Hu, P. Maksimovic, M. Swartz, A. Whitbeck, P. Baringer, A. Bean, G. Benelli, R. P. Kenny, M. Murray, D. Noonan, S. Sanders, R. Stringer, J. S. Wood, A. F. Barfuss, I. Chakaberia, A. Ivanov, S. Khalil, M. Makouski, Y. Maravin, S. Shrestha, I. Svintradze, J. Gronberg, D. Lange, F. Rebassoo, D. Wright, A. Baden, B. Calvert, S. C. Eno, J. A. Gomez, N. J. Hadley, R. G. Kellogg, T. Kolberg, Y. Lu, M. Marionneau, A. C. Mignerey, K. Pedro, A. Peterman, A. Skuja, J. Temple, M. B. Tonjes, S. C. Tonwar, A. Apyan, G. Bauer, W. Busza, E. Butz, I. A. Cali, M. Chan, V. Dutta, G. Gomez Ceballos, M. Goncharov, Y. Kim, M. Klute, Y. S. Lai, A. Levin, P. D. Luckey, T. Ma, S. Nahn, C. Paus, D. Ralph, C. Roland, G. Roland, G. S. F. Stephans, F. Stöckli, K. Sumorok, K. Sung, D. Velicanu, R. Wolf, B. Wyslouch, M. Yang, Y. Yilmaz, A. S. Yoon, M. Zanetti, V. Zhukova, B. Dahmes, A. De Benedetti, G. Franzoni, A. Gude, J. Haupt, S. C. Kao, K. Klapoetke, Y. Kubota, J. Mans, N. Pastika, R. Rusack, M. Sasseville, A. Singovsky, N. Tambe, J. Turkewitz, L. M. Cremaldi, R. Kroeger, L. Perera, R. Rahmat, D. A. Sanders, D. Summers, E. Avdeeva, K. Bloom, S. Bose, D. R. Claes, A. Dominguez, M. Eads, R. Gonzalez Suarez, J. Keller, I. Kravchenko, J. Lazo-Flores, S. Malik, F. Meier, G. R. Snow, J. Dolen, A. Godshalk, I. Iashvili, S. Jain, A. Kharchilava, A. Kumar, S. Rappoccio, Z. Wan, G. Alverson, E. Barberis, D. Baumgartel, M. Chasco, J. Haley, A. Massironi, D. Nash, T. Orimoto, D. Trocino, D. Wood, J. Zhang, A. Anastassov, K. A. Hahn, A. Kubik, L. Lusito, N. Mucia, N. Odell, B. Pollack, A. Pozdnyakov, M. Schmitt, S. Stoynev, M. Velasco, S. Won, D. Berry, A. Brinkerhoff, K. M. Chan, M. Hildreth, C. Jessop, D. J. Karmgard, J. Kolb, K. Lannon, W. Luo, S. Lynch, N. Marinelli, D. M. Morse, T. Pearson, M. Planer, R. Ruchti, J. Slaunwhite, N. Valls, M. Wayne, M. Wolf, L. Antonelli, B. Bylsma, L. S. Durkin, C. Hill, R. Hughes, K. Kotov, T. Y. Ling, D. Puigh, M. Rodenburg, G. Smith, C. Vuosalo, G. Williams, B. L. Winer, H. Wolfe, E. Berry, P. Elmer, V. Halyo, P. Hebda, J. Hegeman, A. Hunt, P. Jindal, S. A. Koay, D. Lopes Pegna, P. Lujan, D. Marlow, T. Medvedeva, M. Mooney, J. Olsen, P. Piroué, X. Quan, A. Raval, H. Saka, D. Stickland, C. Tully, J. S. Werner, S. C. Zenz, A. Zuranski, E. Brownson, A. Lopez, H. Mendez, J. E. Ramirez Vargas, E. Alagoz, D. Benedetti, G. Bolla, D. Bortoletto, M. De Mattia, A. Everett, Z. Hu, M. Jones, K. Jung, O. Koybasi, M. Kress, N. Leonardo, V. Maroussov, P. Merkel, D. H. Miller, N. Neumeister, I. Shipsey, D. Silvers, A. Svyatkovskiy, M. Vidal Marono, F. Wang, L. Xu, H. D. Yoo, J. Zablocki, Y. Zheng, S. Guragain, N. Parashar, A. Adair, B. Akgun, K. M. Ecklund, F. J. M. Geurts, B. P. Padley, R. Redjimi, J. Roberts, J. Zabel, B. Betchart, A. Bodek, R. Covarelli, P. de Barbaro, R. Demina, Y. Eshaq, T. Ferbel, A. Garcia-Bellido, P. Goldenzweig, J. Han, A. Harel, D. C. Miner, G. Petrillo, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Goulianos, G. Lungu, C. Mesropian, S. Arora, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, A. Lath, S. Panwalkar, M. Park, R. Patel, V. Rekovic, J. Robles, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thomas, M. Walker, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, J. Damgov, C. Dragoiu, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, I. Volobouev, E. Appelt, A. G. Delannoy, S. Greene, A. Gurrola, W. Johns, C. Maguire, A. Melo, M. Sharma, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, S. Boutle, B. Cox, B. Francis, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, A. Sakharov, M. Anderson, D. A. Belknap, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, E. Friis, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, K. Kaadze, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, R. Loveless, A. Mohapatra, M. U. Mozer, I. Ojalvo, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2022
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77. LO-021 Interim safety and efficacy of subcutaneous (s.c.) dose ianalumab (VAY736; anti-BAFF-R mAb) administered monthly over 28 weeks in patients with systemic lupus erythematosus (SLE)

Author

Yuko Kaneko, Masato Okada, Stephanie Finzel, Nan Shen, Elena Vishneva, Lingyun Sun, Bernadette Rojkovich, Alberta Hoi, Shin-Seok Lee, Piotr Leszczyński, Lie Dai, Rafal Wojciechowski, Cheng-Chung Wei, Katarzyna Romanowska-Prochnicka, Hiroshi Kaneko, Stanislav Ignatenko, Alexander Gordienko, Josefina Hernandez, Nancy Levin, Pongthorn Narongroeknawin, Hanna Ciferska, Masanari Kodera, Joung Liang Lan, Tunde Tarr, Yi Hsing Chen, Ajchara Koolvisoot, Eugeny Zotkin, Berta Paula magallares, Tirtha Sengupta, Carole Sips, and Stephan Oliver

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2023
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80. Résultats de phase 2 d’efficacité et de tolérance jusqu’à 52 semaines du ianalumab, anti-BAFF récepteur (BAFF-R), chez les patients atteints de lupus érythémateux systémique (LES)

Author

Lazaro, E., primary, Agmon-Levin, N., additional, Ignatenko, S., additional, Gordienko, A., additional, Cortes-Hernandez, J., additional, Narongroeknawin, P., additional, Romanowska-Prochnicka, K., additional, Shen, N., additional, Ciferska, H., additional, Kodera, M., additional, Wei, C.C., additional, Leszczynski, P., additional, Lan, J.L., additional, Mysler, E., additional, Wojciechowski, R., additional, Tarr, T., additional, Vishneva, E., additional, Chen, Y.H., additional, Kaneko, Y., additional, Finzel, S., additional, Hoi, A., additional, Okada, M., additional, Koolvisoot, A., additional, Lee, S.S., additional, Dai, L., additional, Kaneko, H., additional, Rojkovich, B., additional, Sun, L., additional, Zotkin, E., additional, Magallares, B.P., additional, Sengupta, T., additional, Sips, C., additional, Oliver, S., additional, Avrameas, A., additional, and Lau, C., additional

Published
2024
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83. The Influence of the Chemical Composition of Flax and Hemp Fibers on the Value of Surface Free Energy

Author

Barbara Romanowska, Wanda Różańska, and Małgorzata Zimniewska

Subjects
flax fibers, hemp fibers, surface free energy, wettability, lignin, pectin, Technology, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Engineering (General). Civil engineering (General), TA1-2040, Microscopy, QH201-278.5, Descriptive and experimental mechanics, QC120-168.85
Abstract

The article presents the exploration of flax and hemp fibers’ surface free energy depending on the chemical composition of the fiber, which is closely related to the plant variety and the method of extracting the fiber. For this purpose, tests of the surface free energy (SFE), evaluation of the percentage content of individual fiber components and FTIR analyses were conducted. The research was carried out with the use of fibrous materials prepared in three different ways: 1. To analyze the effect of subsequent stages of flax fibers refining process on chemical composition and SFE, 2. to explore the dependence of fiber SFE on hemp variety, the water-retting hemp fibers were used, 3. To evaluate the influence of the retting method of hemp fibers BIAŁOBRZESKIE variety on SFE, the fibers extracted with the use of dew and water retting were used as the research material. The study confirmed that the content of individual components in the fiber influenced its sorption capacity and therefore determined its hydrophilic properties. The values of Pearson’s linear correlation coefficients determined in the statistical analysis proved that the surface free energy was strongly correlated with the content of individual components in the fibers. Understanding the wettability characteristics of bast fibers will allow modeling the properties of products made of these fibers and designing surface modification processes in order to obtain specific functionality of textile products, depending on their intended utilization.

Published
2024
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84. Use of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Diagnosis and Follow-Up of Endogenous Candida Endophthalmitis: A Case Report

Author

Agnieszka Kubicka-Trząska, Dawid Bugara, Katarzyna Żuber-Łaskawiec, Weronika Pociej-Marciak, Anna Markiewicz, Bożena Romanowska-Dixon, and Izabella Karska-Basta

Subjects
optical coherence tomography, optical coherence tomography angiography, endogenous Candida endophthalmitis, macular neovascularization, intravitreal injection, Medicine (General), R5-920
Abstract

Background: Endogenous Candida endophthalmitis (ECE) is a rare but sight-threatening disease. Patients with ECE present with various clinical signs and symptoms, which can complicate the diagnosis. The aim of this report was to demonstrate the outcomes of treatment and to diagnose macular complications caused by intraocular inflammation. Case presentation: A 41-year-old woman with a history of acute intermittent porphyria presented with a progressive vision loss in her left eye. Left-eye OCT revealed findings consistent with a fungal etiology, which was confirmed by the culture of swabs collected from a central vein catheter. The outcomes of intravenous fluconazole treatment were not satisfactory, and the patient developed recurrent attacks of porphyria, suggesting a porphyrogenic effect of systemic antifungal therapy. Repeated intravitreal injections with amphotericin B led to a gradual regression of inflammatory lesions. However, follow-up examinations revealed active macular neovascularization (MNV) on both OCT and OCTA scans. The patient was administered intravitreal bevacizumab. At the 11th month of follow-up, OCT and OCTA scans showed significant inflammatory lesions regression with macula scarring, and no MNV activity was detected. Conclusions: This case highlights the importance of OCT and OCTA as valuable noninvasive imaging techniques for the identification of ECE, the monitoring of its clinical course, and the diagnosis of macular complications.

Published
2024
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85. The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme

Author

Łukasz A. Poniatowski, Michał Woźnica, Piotr Wojdasiewicz, Aneta Mela-Kalicka, Katarzyna Romanowska-Próchnicka, Daryush Purrahman, Grzegorz Żurek, Maciej Krawczyk, Najmeh Nameh Goshay Fard, Marzena Furtak-Niczyporuk, Janusz Jaroszyński, Mohammad-Reza Mahmoudian-Sani, and Ilona Joniec-Maciejak

Subjects
progranulin, glioblastoma multiforme, brain tumour, oncogenesis, drug resistance, temozolomide, Cytology, QH573-671
Abstract

Glioblastoma multiforme (GBM) represents the most common and aggressive malignant form of brain tumour in adults and is characterized by an extremely poor prognosis with dismal survival rates. Currently, expanding concepts concerning the pathophysiology of GBM are inextricably linked with neuroinflammatory phenomena. On account of this fact, the identification of novel pathomechanisms targeting neuroinflammation seems to be crucial in terms of yielding successful individual therapeutic strategies. In recent years, the pleiotropic growth factor progranulin (PGRN) has attracted significant attention in the neuroscience and oncological community regarding its neuroimmunomodulatory and oncogenic functions. This review of the literature summarizes and updates contemporary knowledge about PGRN, its associated receptors and signalling pathway involvement in GBM pathogenesis, indicating possible cellular and molecular mechanisms with potential diagnostic, prognostic and therapeutic targets in order to yield successful individual therapeutic strategies. After a review of the literature, we found that there are possible PGRN-targeted therapeutic approaches for implementation in GBM treatment algorithms both in preclinical and future clinical studies. Furthermore, PGRN-targeted therapies exerted their highest efficacy in combination with other established chemotherapeutic agents, such as temozolomide. The results of the analysis suggested that the possible implementation of routine determinations of PGRN and its associated receptors in tumour tissue and biofluids could serve as a diagnostic and prognostic biomarker of GBM. Furthermore, promising preclinical applications of PGRN-related findings should be investigated in clinical studies in order to create new diagnostic and therapeutic algorithms for GBM treatment.

Published
2024
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86. Torrefaction of Willow in Batch Reactor and Co-Firing of Torrefied Willow with Coal

Author

Hilal Unyay, Piotr Piersa, Magdalena Zabochnicka, Zdzisława Romanowska-Duda, Piotr Kuryło, Ksawery Kuligowski, Paweł Kazimierski, Taras Hutsol, Arkadiusz Dyjakon, Edyta Wrzesińska-Jędrusiak, Andrzej Obraniak, and Szymon Szufa

Subjects
torrefaction, co-torrefaction, biochar, reactor design, TGA-FTIR, TG/MS, Technology
Abstract

The torrefaction process represents a thermal conversion technique conducted at relatively low temperatures ranging between 200 to 300 °C. Its objective is to produce fuel with a higher energy density by decomposing the reactive portion of hemicellulose. In this study, the kinetics of mass loss during torrefaction were investigated for willow. The experiments were carried out under isothermal conditions using thermogravimetric analysis. Batch torrefaction reactor designs were conducted and explained in detail. Co-combustion of willow with hard coal (origin: Katowice mine) in different mass ratios (25% biomass + 75% coal, 50% biomass + 50% coal, and 75% biomass + 25% coal) was conducted in addition to raw biomass torrefaction. TG/MS analysis (a combination of thermogravimetric analysis with mass spectrometry analysis) was performed in the research. The optimal torrefaction conditions for willow were identified as an average temperature of 245 °C and a residence time of 14 min, resulting in the lowest mass loss (30.15%). However, it was noted that the composition of torgas, a by-product of torrefaction, presents challenges in providing a combustible gas with sufficient heat flux to meet the energy needs of the process. Prolonged residence times over 15 min and higher average temperatures above 250 °C lead to excessive energy losses from volatile torrefaction products, making them suboptimal for willow. On the other hand, the co-combustion of torrefied biomass with hard coal offers advantages in reduced sulfur emissions but can lead to increased NOx emissions when biomass with a higher nitrogen content is co-combusted in proportions exceeding 50% biomass. This paper summarizes findings related to optimizing torrefaction conditions, challenges in torgas composition, and the emissions implications of co-combustion.

Published
2023
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93. Automatic air volume control system for ventilation of two patients using a single ventilator: a large animal model study

Author

Zieliński, Krzysztof, Lisowska, Barbara, Siewruk, Katarzyna, Sady, Maria, Ferenc, Karolina, Barwijuk, Maciej, Olszewski, Jarosław, Anusz, Krzysztof, Jabłoński, Artur, Gajewska, Magdalena, Okrzeja, Piotr, Michnikowski, Marcin, Pijanowska, Dorota G., Pluta, Krzysztof, Remiszewska, Elżbieta, Darowski, Marek, Zabielski, Romuald, Liebert, Adam, Kramek-Romanowska, Katarzyna, Stecka, Anna, Kozarski, Maciej, Pasledni, Raman, Gajewski, Zdzisław, and Ładyżyński, Piotr

Published
2022
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94. Erratum to: Searches for long-lived charged particles in pp collisions at s = 7 and 8 TeV

Author

Chatrchyan, S., Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., Erö, J., Fabjan, C., Friedl, M., Frühwirth, R., Ghete, V. M., Hörmann, N., Hrubec, J., Jeitler, M., Kiesenhofer, W., Knünz, V., Krammer, M., Krätschmer, I., Liko, D., Mikulec, I., Rabady, D., Rahbaran, B., Rohringer, C., Rohringer, H., Schöfbeck, R., Strauss, J., Taurok, A., Treberer-Treberspurg, W., Waltenberger, W., Wulz, C.-E., Mossolov, V., Shumeiko, N., Suarez Gonzalez, J., Alderweireldt, S., Bansal, M., Bansal, S., Cornelis, T., De Wolf, E. A., Janssen, X., Knutsson, A., Luyckx, S., Mucibello, L., Ochesanu, S., Roland, B., Rougny, R., Van Haevermaet, H., Van Mechelen, P., Van Remortel, N., Van Spilbeeck, A., Blekman, F., Blyweert, S., D’Hondt, J., Kalogeropoulos, A., Keaveney, J., Maes, M., Olbrechts, A., Tavernier, S., Van Doninck, W., Van Mulders, P., Van Onsem, G. P., Villella, I., Clerbaux, B., De Lentdecker, G., Favart, L., Gay, A. P. R., Hreus, T., Léonard, A., Marage, P. E., Mohammadi, A., Perniè, L., Reis, T., Seva, T., Thomas, L., Vander Velde, C., Vanlaer, P., Wang, J., Adler, V., Beernaert, K., Benucci, L., Cimmino, A., Costantini, S., Dildick, S., Garcia, G., Klein, B., Lellouch, J., Marinov, A., Mccartin, J., Ocampo Rios, A. A., Ryckbosch, D., Sigamani, M., Strobbe, N., Thyssen, F., Tytgat, M., Walsh, S., Yazgan, E., Zaganidis, N., Basegmez, S., Beluffi, C., Bruno, G., Castello, R., Caudron, A., Ceard, L., Delaere, C., du Pree, T., Favart, D., Forthomme, L., Giammanco, A., Hollar, J., Jez, P., Lemaitre, V., Liao, J., Militaru, O., Nuttens, C., Pagano, D., Pin, A., Piotrzkowski, K., Popov, A., Selvaggi, M., Vizan Garcia, J. M., Beliy, N., Caebergs, T., Daubie, E., Hammad, G. H., Alves, G. A., Correa Martins Junior, M., Martins, T., Pol, M. E., Souza, M. H. G., Aldá Júnior, W. L., Carvalho, W., Chinellato, J., Custódio, A., Da Costa, E. M., De Jesus Damiao, D., De Oliveira Martins, C., Fonseca De Souza, S., Malbouisson, H., Malek, M., Matos Figueiredo, D., Mundim, L., Nogima, H., Prado Da Silva, W. L., Santoro, A., Sznajder, A., Tonelli Manganote, E. J., Vilela Pereira, A., Bernardes, C. A., Dias, F. A., Fernandez Perez Tomei, T. R., Gregores, E. M., Lagana, C., Marinho, F., Mercadante, P. G., Novaes, S. F., Padula, Sandra S., Genchev, V., Iaydjiev, P., Piperov, S., Rodozov, M., Sultanov, G., Vutova, M., Dimitrov, A., Hadjiiska, R., Kozhuharov, V., Litov, L., Pavlov, B., Petkov, P., Bian, J. G., Chen, G. M., Chen, H. S., Jiang, C. H., Liang, D., Liang, S., Meng, X., Tao, J., Wang, J., Wang, X., Wang, Z., Xiao, H., Xu, M., Asawatangtrakuldee, C., Ban, Y., Guo, Y., Li, W., Liu, S., Mao, Y., Qian, S. J., Teng, H., Wang, D., Zhang, L., Zou, W., Avila, C., Carrillo Montoya, C. A., Gomez, J. P., Gomez Moreno, B., Sanabria, J. C., Godinovic, N., Lelas, D., Plestina, R., Polic, D., Puljak, I., Antunovic, Z., Kovac, M., Brigljevic, V., Duric, S., Kadija, K., Luetic, J., Mekterovic, D., Morovic, S., Tikvica, L., Attikis, A., Mavromanolakis, G., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Finger, M., Finger, Jr., M., Assran, Y., Ellithi Kamel, A., Mahmoud, M. A., Mahrous, A., Radi, A., Kadastik, M., Müntel, M., Murumaa, M., Raidal, M., Rebane, L., Tiko, A., Eerola, P., Fedi, G., Voutilainen, M., Härkönen, J., Karimäki, V., Kinnunen, R., Kortelainen, M. J., Lampén, T., Lassila-Perini, K., Lehti, S., Lindén, T., Luukka, P., Mäenpää, T., Peltola, T., Tuominen, E., Tuominiemi, J., Tuovinen, E., Wendland, L., Korpela, A., Tuuva, T., Besancon, M., Choudhury, S., Couderc, F., Dejardin, M., Denegri, D., Fabbro, B., Faure, J. 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A., Sonnenschein, L., Steggemann, J., Teyssier, D., Thüer, S., Weber, M., Cherepanov, V., Erdogan, Y., Flügge, G., Geenen, H., Geisler, M., Haj Ahmad, W., Hoehle, F., Kargoll, B., Kress, T., Kuessel, Y., Lingemann, J., Nowack, A., Nugent, I. M., Perchalla, L., Pooth, O., Stahl, A., Aldaya Martin, M., Asin, I., Bartosik, N., Behr, J., Behrenhoff, W., Behrens, U., Bergholz, M., Bethani, A., Borras, K., Burgmeier, A., Cakir, A., Calligaris, L., Campbell, A., Costanza, F., Diez Pardos, C., Dooling, S., Dorland, T., Eckerlin, G., Eckstein, D., Flucke, G., Geiser, A., Glushkov, I., Gunnellini, P., Habib, S., Hauk, J., Hellwig, G., Jung, H., Kasemann, M., Katsas, P., Kleinwort, C., Kluge, H., Krämer, M., Krücker, D., Kuznetsova, E., Lange, W., Leonard, J., Lipka, K., Lohmann, W., Lutz, B., Mankel, R., Marfin, I., Melzer-Pellmann, I.-A., Meyer, A. 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R., Kornmayer, A., Lobelle Pardo, P., Martschei, D., Mueller, S., Müller, Th., Niegel, M., Nürnberg, A., Oberst, O., Ott, J., Quast, G., Rabbertz, K., Ratnikov, F., Röcker, S., Schilling, F.-P., Schott, G., Simonis, H. J., Stober, F. M., Ulrich, R., Wagner-Kuhr, J., Wayand, S., Weiler, T., Zeise, M., Anagnostou, G., Daskalakis, G., Geralis, T., Kesisoglou, S., Kyriakis, A., Loukas, D., Markou, A., Markou, C., Ntomari, E., Gouskos, L., Mertzimekis, T. J., Panagiotou, A., Saoulidou, N., Stiliaris, E., Aslanoglou, X., Evangelou, I., Flouris, G., Foudas, C., Kokkas, P., Manthos, N., Papadopoulos, I., Paradas, E., Bencze, G., Hajdu, C., Hidas, P., Horvath, D., Radics, B., Sikler, F., Veszpremi, V., Vesztergombi, G., Zsigmond, A. J., Beni, N., Czellar, S., Molnar, J., Palinkas, J., Szillasi, Z., Karancsi, J., Raics, P., Trocsanyi, Z. L., Ujvari, B., Beri, S. B., Bhatnagar, V., Dhingra, N., Gupta, R., Kaur, M., Mehta, M. Z., Mittal, M., Nishu, N., Saini, L. K., Sharma, A., Singh, J. B., Kumar, Ashok, Kumar, Arun, Ahuja, S., Bhardwaj, A., Choudhary, B. C., Malhotra, S., Naimuddin, M., Ranjan, K., Saxena, P., Sharma, V., Shivpuri, R. K., Banerjee, S., Bhattacharya, S., Chatterjee, K., Dutta, S., Gomber, B., Jain, Sa., Jain, Sh., Khurana, R., Modak, A., Mukherjee, S., Roy, D., Sarkar, S., Sharan, M., Abdulsalam, A., Dutta, D., Kailas, S., Kumar, V., Mohanty, A. K., Pant, L. M., Shukla, P., Topkar, A., Aziz, T., Chatterjee, R. M., Ganguly, S., Ghosh, S., Guchait, M., Gurtu, A., Kole, G., Kumar, S., Maity, M., Majumder, G., Mazumdar, K., Mohanty, G. B., Parida, B., Sudhakar, K., Wickramage, N., Banerjee, S., Dugad, S., Arfaei, H., Bakhshiansohi, H., Etesami, S. M., Fahim, A., Hesari, H., Jafari, A., Khakzad, M., Mohammadi Najafabadi, M., Paktinat Mehdiabadi, S., Safarzadeh, B., Zeinali, M., Grunewald, M., Abbrescia, M., Barbone, L., Calabria, C., Chhibra, S. S., Colaleo, A., Creanza, D., De Filippis, N., De Palma, M., Fiore, L., Iaselli, G., Maggi, G., Maggi, M., Marangelli, B., My, S., Nuzzo, S., Pacifico, N., Pompili, A., Pugliese, G., Selvaggi, G., Silvestris, L., Singh, G., Venditti, R., Verwilligen, P., Zito, G., Abbiendi, G., Benvenuti, A. C., Bonacorsi, D., Braibant-Giacomelli, S., Brigliadori, L., Campanini, R., Capiluppi, P., Castro, A., Cavallo, F. R., Cuffiani, M., Dallavalle, G. M., Fabbri, F., Fanfani, A., Fasanella, D., Giacomelli, P., Grandi, C., Guiducci, L., Marcellini, S., Masetti, G., Meneghelli, M., Montanari, A., Navarria, F. L., Odorici, F., Perrotta, A., Primavera, F., Rossi, A. M., Rovelli, T., Siroli, G. 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A., Shoaib, M., Bialkowska, H., Boimska, B., Frueboes, T., Górski, M., Kazana, M., Nawrocki, K., Romanowska-Rybinska, K., Szleper, M., Wrochna, G., Zalewski, P., Brona, G., Bunkowski, K., Cwiok, M., Dominik, W., Doroba, K., Kalinowski, A., Konecki, M., Krolikowski, J., Misiura, M., Wolszczak, W., Almeida, N., Bargassa, P., David, A., Faccioli, P., Ferreira Parracho, P. G., Gallinaro, M., Rodrigues Antunes, J., Seixas, J., Varela, J., Vischia, P., Bunin, P., Gavrilenko, M., Golutvin, I., Gorbunov, I., Kamenev, A., Karjavin, V., Konoplyanikov, V., Kozlov, G., Lanev, A., Malakhov, A., Matveev, V., Moisenz, P., Palichik, V., Perelygin, V., Shmatov, S., Skatchkov, N., Smirnov, V., Zarubin, A., Evstyukhin, S., Golovtsov, V., Ivanov, Y., Kim, V., Levchenko, P., Murzin, V., Oreshkin, V., Smirnov, I., Sulimov, V., Uvarov, L., Vavilov, S., Vorobyev, A., Vorobyev, An., Andreev, Yu., Dermenev, A., Gninenko, S., Golubev, N., Kirsanov, M., Krasnikov, N., Pashenkov, A., Tlisov, D., Toropin, A., Epshteyn, V., Erofeeva, M., Gavrilov, V., Lychkovskaya, N., Popov, V., Safronov, G., Semenov, S., Spiridonov, A., Stolin, V., Vlasov, E., Zhokin, A., Andreev, V., Azarkin, M., Dremin, I., Kirakosyan, M., Leonidov, A., Mesyats, G., Rusakov, S. 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F., Brun, H., Cuevas, J., Fernandez Menendez, J., Folgueras, S., Gonzalez Caballero, I., Lloret Iglesias, L., Piedra Gomez, J., Brochero Cifuentes, J. A., Cabrillo, I. J., Calderon, A., Chuang, S. H., Duarte Campderros, J., Fernandez, M., Gomez, G., Gonzalez Sanchez, J., Graziano, A., Jorda, C., Lopez Virto, A., Marco, J., Marco, R., Martinez Rivero, C., Matorras, F., Munoz Sanchez, F. J., Rodrigo, T., Rodríguez-Marrero, A. Y., Ruiz-Jimeno, A., Scodellaro, L., Vila, I., Vilar Cortabitarte, R., Abbaneo, D., Auffray, E., Auzinger, G., Bachtis, M., Baillon, P., Ball, A. H., Barney, D., Bendavid, J., Benitez, J. F., Bernet, C., Bianchi, G., Bloch, P., Bocci, A., Bonato, A., Bondu, O., Botta, C., Breuker, H., Camporesi, T., Cerminara, G., Christiansen, T., Coarasa Perez, J. 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R., Jeong, C., Kovitanggoon, K., Lee, S. W., Libeiro, T., Volobouev, I., Appelt, E., Delannoy, A. G., Greene, S., Gurrola, A., Johns, W., Maguire, C., Mao, Y., Melo, A., Sharma, M., Sheldon, P., Snook, B., Tuo, S., Velkovska, J., Arenton, M. W., Boutle, S., Cox, B., Francis, B., Goodell, J., Hirosky, R., Ledovskoy, A., Lin, C., Neu, C., Wood, J., Gollapinni, S., Harr, R., Karchin, P. E., Kottachchi Kankanamge Don, C., Lamichhane, P., Sakharov, A., Anderson, M., Belknap, D. A., Borrello, L., Carlsmith, D., Cepeda, M., Dasu, S., Friis, E., Grogg, K. S., Grothe, M., Hall-Wilton, R., Herndon, M., Hervé, A., Kaadze, K., Klabbers, P., Klukas, J., Lanaro, A., Lazaridis, C., Loveless, R., Mohapatra, A., Mozer, M. U., Ojalvo, I., Pierro, G. A., Ross, I., Savin, A., Smith, W. H., and Swanson, J.

Published
2022
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96. Role of Plasma Angiopoietin-1 and VEGF Levels as Potential Biomarkers in Chronic Central Serous Chorioretinopathy with Macular Neovascularization.

Author

Chrząszcz, Michał, Pociej-Marciak, Weronika, Mackiewicz, Natalia, Romanowska-Dixon, Bożena, Sanak, Marek, Teper, Sławomir, Gawęcki, Maciej, and Karska-Basta, Izabella

Subjects
VASCULAR endothelial growth factors, FLUORESCENCE angiography, CHOROID, OPTICAL coherence tomography, ANGIOPOIETIN-1
Abstract

To evaluate the plasma levels of angiopoietin-1 and vascular endothelial growth factor (VEGF) and their association with macular neovascularization (MNV) in patients with chronic central serous chorioretinopathy (cCSC). Correlations between plasma cytokine levels, CSC duration, and mean choroidal thickness (CT) were also investigated. Of the 59 patients with cCSC, 10 patients with MNV secondary to cCSC and 10 patients with cCSC without MNV were enrolled in the study. The control group included 15 healthy volunteers matched for age, sex, smoking status, and comorbidities. Chronic CSC was diagnosed based on typical findings on swept-source optical coherence tomography (OCT), fundus fluorescein angiography, and indocyanine green angiography. Additionally, all patients underwent OCT angiography to help detect MNV. Plasma angiopoietin-1 and VEGF levels were assessed using multiplex immunoassay. The plasma angiopoietin-1 levels differed between the 3 groups (p = 0.005). The angiopoietin-1 levels were lower in patients with cCSC with MNV than in controls (p = 0.006). There were no differences in the plasma VEGF levels between all the 3 groups (p = 0.329). The VEGF levels were negatively correlated with mean CT in cCSC patients with MNV (rho = −0.683, p = 0.042) but correlated positively with disease duration in patients with cCSC without MNV (rho = 0.886, p = 0.003). Our study confirms that MNV is a common complication of cCSC and provides new insights into the role of angiopoietin-1 in cCSC and MNV. Reduced angiopoietin-1 levels in cCSC patients, regardless of MNV status, highlight the importance of the Ang–Tie2 pathway in disease pathogenesis and may point to new therapeutic targets and future novel treatments to improve the management of these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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97. Increasing Fertilization Efficiency of Biomass Ash by the Synergistically Acting Digestate and Extract from Water Plants Sequestering CO 2 in Sorghum Crops.

Author

Romanowska-Duda, Zdzisława, Janas, Regina, and Grzesik, Mieczysław

Subjects
*SUSTAINABLE agriculture, *JERUSALEM artichoke, *BIOMASS energy, *ACID phosphatase, *SYNTHETIC fertilizers, *SORGHUM
Abstract

The utilization of biomass ash in sustainable agriculture and increasing its fertilizing efficiency by biological agents, potentially sequestering CO2, have become important issues for the global economy. The aim of this paper was to investigate the effects of ash from sorghum (Sorghum bicolor L. Moench) and Jerusalem artichoke (Helianthus tuberosus L.) biomass, a biogas plant digestate, and a Spirodela polyrhiza extract, acting alone or synergistically, on soil fertility and the development, health and physiological properties of sorghum plants. The results show novel information concerning differences in the composition and impact of ash, depending on its origin, soil properties and sorghum plant development. Sorghum ash was more effective than that from Jerusalem artichoke. Ash used alone and preferably acting synergistically with the digestate and Spirodela polyrhiza extract greatly increased soil fertility and the growth, biomass yield and health of sorghum plants. These improvements were associated with an increased chlorophyll content in leaves, better gas exchange (photosynthesis, transpiration, stomatal conductance), greater enzyme activity (acid and alkaline phosphatase, RNase, and total dehydrogenase), and a higher biomass energy value. The developed treatments improved environmental conditions by replacing synthetic fertilizers, increasing the sequestration of CO2, solving the ash storage problem, reducing the need for pesticides, and enabling a closed circulation of nutrients between plant and soil, maintaining high soil fertility. [ABSTRACT FROM AUTHOR]

Published
2024
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98. Assessment of Urinary Dopamine and Serotonin Metabolites in Relation to Dysbiosis Indicators in Patients with Functional Constipation.

Author

Chojnacki, Jan, Popławski, Tomasz, Kaczka, Aleksandra, Romanowska, Natalia, Chojnacki, Cezary, and Gąsiorowska, Anita

Abstract

Background: The causes of functional constipation (FC) in adults are unclear, but changes in the gut microbiome may play an important role. The present study aimed to assess the relationship between urinary metabolites of dopamine and serotonin and some dysbiosis indicators in patients with FC. The study included 40 healthy women and 40 women with FC aged 21–46 years. Methods: Urinary levels of homovanillic acid (HVA), 5-hydoxyindoleacetic acid (5-HIAA), p-hydroxyphenylacetic acid (PhAc), and 3-indoxyl sulfate, as final metabolites of dopamine, serotonin, and indole pathway, respectively, were determined using the LC-Ms/Ms method. However, hydrogen–methane and ammonia breath tests were performed. The GA-map Dysbiosis Test was used to identify and characterize the dysbiosis index (DI). Results: In patients with FC, the DI was significantly higher than in the control group: 4.05 ± 0.53 vs. 1.52 ± 0.81 points (p < 0.001), but the number of many types of bacteria varied among individuals. The levels of HVA were higher, while 5-HIAA levels were lower in patients. Moreover, the HVA/5-HIAA ratio had a positive correlation with DI as well as with the severity of symptoms. Conclusions: In patients with functional constipation, the balance in dopamine and serotonin secretion is disturbed, which is associated with changes in the gut microbiome. [ABSTRACT FROM AUTHOR]

Published
2024
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99. Specification and Description Language Models Automatic Execution in a High-Performance Environment

Author

Pau Fonseca i Casas, Iza Romanowska, and Joan Garcia i Subirana

Subjects
SDL, HPC, SDLPS, social simulation, prime numbers, Electronic computers. Computer science, QA75.5-76.95
Abstract

Specification and Description Language (SDL) is a language that can represent the behavior and structure of a model completely and unambiguously. It allows the creation of frameworks that can run a model without the need to code it in a specific programming language. This automatic process simplifies the key phases of model building: validation and verification. SDLPS is a simulator that enables the definition and execution of models using SDL. In this paper, we present a new library that enables the execution of SDL models defined on SDLPS infrastructure on a HPC platform, such as a supercomputer, thus significantly speeding up simulation runtime. Moreover, we apply the SDL language to a social science use case, thus opening a new avenue for facilitating the use of HPC power to new groups of users. The tools presented here have the potential to increase the robustness of modeling software by improving the documentation, verification, and validation of the models.

Published
2023
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100. The Quantity and Quality of Flax and Hemp Fibers Obtained Using the Osmotic, Water-, and Dew-Retting Processes

Author

Wanda Różańska, Barbara Romanowska, and Szymon Rojewski

Subjects
flax (Linum usitatissimum L.) fibers, hemp (Cannabis sativa L.) fibers, osmotic degumming, dew retting, water retting, Technology, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Engineering (General). Civil engineering (General), TA1-2040, Microscopy, QH201-278.5, Descriptive and experimental mechanics, QC120-168.85
Abstract

This study presents the quantity and quality of flax (Linum usitatissimum L.) and hemp (Cannabis sativa L.) fibers obtained depending on the fiber extraction method. The extraction methods used in this study were osmotic degumming, dew retting, and water retting. The degummed straw was analyzed for fiber content, while the metrological, chemical, and physical properties were determined for the fibers obtained. It was shown that these properties change based on the method of fiber extraction used. The highest fiber content in the straw was obtained using the osmotic degumming method. These fibers are characterized by a light color, no unpleasant odor, low linear mass, good tenacity, lowest hygroscopicity, and reduced flammability compared to fibers obtained via the dew and water retting of straw.

Published
2023
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