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51. Predictive Value of Nutritional Risk for All-Cause Death and Functional Outcomes in Chinese Elderly Patients with Acute Stroke: A 3-Year Follow-Up Study [Letter]

Author

Qiu X and Nong Y

Subjects
acute stroke, malnutrition, nutritional screening, all-cause death, gnri, nrs-2002, Geriatrics, RC952-954.6
Abstract

Xiaoqin Qiu,1 Yuechou Nong2 1Department of Nursing, The Guangxi Hospital of the First Affiliated Hospital of Sun Yat-sen University, Nanning, Guangxi, 530021, People’s Republic of China; 2Department of Endocrinology and Metabolism, The Guangxi Academy of Medical Sciences, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People’s Republic of ChinaCorrespondence: Yuechou Nong, Email yuechou_gx@163.com

Published
2024

52. Improved Constraints on Sterile Neutrino Mixing from Disappearance Searches in the MINOS, MINOS+, Daya Bay, and Bugey-3 Experiments

Author

Bay, Daya, Collaborations, MINOS, Adamson, P., An, F. P., Anghel, I., Aurisano, A., Balantekin, A. B., Band, H. R., Barr, G., Bishai, M., Blake, A., Blyth, S., Cao, G. F., Cao, J., Cao, S. V., Carroll, T. J., Castromonte, C. M., Chang, J. F., Chang, Y., Chen, H. S., Chen, R., Chen, S. M., Chen, Y., Chen, Y. X., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Childress, S., Chu, M. C., Chukanov, A., Coelho, J. A. B., Cummings, J. P., Dash, N., De Rijck, S., Deng, F. S., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dvořák, M., Dwyer, D. A., Evans, J. J., Feldman, G. J., Flanagan, W., Gabrielyan, M., Gallo, J. P., Germani, S., Gomes, R. A., Gonchar, M., Gong, G. H., Gong, H., Gouffon, P., Graf, N., Grzelak, K., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Habig, A., Hackenburg, R. W., Hahn, S. R., Hans, S., Hartnell, J., Hatcher, R., He, M., Heeger, K. M., Heng, Y. K., Higuera, A., Holin, A., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Koerner, L. W., Kohn, S., Kordosky, M., Kramer, M., Kreymer, A., Lang, K., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, S., Li, S. C., Li, S. J., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, Y., Liu, Y. H., Lu, C., Lu, H. Q., Lu, J. S., Lucas, P., Luk, K. B., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mann, W. A., Marshak, M. L., Marshall, C., Caicedo, D. A. Martinez, Mayer, N., McDonald, K. T., McKeown, R. D., Mehdiyev, R., Meier, J. R., Meng, Y., Miller, W. H., Mills, G., Lepin, L. Mora, Naples, D., Napolitano, J., Naumov, D., Naumova, E., Nelson, J. K., Nichol, R. J., O'Connor, J., Ochoa-Ricoux, J. P., Olshevskiy, A., Pahlka, R. B., Pan, H. -R., Park, J., Patton, S., Pavlović, Z., Pawloski, G., Peng, J. C., Perch, A., Pfützner, M. M., Phan, D. D., Plunkett, R. K., Poonthottathil, N., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Qiu, X., Radovic, A., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Sail, P., Sanchez, M. C., Schneps, J., Schreckenberger, A., Shaheed, N., Sharma, R., Sousa, A., Steiner, H., Sun, J. L., Tagg, N., Thomas, J., Thomson, M. A., Timmons, A., Tmej, T., Todd, J., Tognini, S. C., Toner, R., Torretta, D., Treskov, K., Tse, W. -H., Tull, C. E., Vahle, P., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y., Wang, Y. F., Wang, Z., Wang, Z. M., Weber, A., Wei, H. Y., Wei, L. H., Wen, L. J., Whisnant, K., White, C., Whitehead, L. H., Wojcicki, S. G., Wong, H. L. H., Wong, S. C. F., Worcester, E., Wu, D. R., Wu, F. L., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. W., Zhang, Q. M., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhou, L., and Zhuang, H. L.

Subjects
High Energy Physics - Experiment
Abstract

Searches for electron antineutrino, muon neutrino, and muon antineutrino disappearance driven by sterile neutrino mixing have been carried out by the Daya Bay and MINOS+ collaborations. This Letter presents the combined results of these searches, along with exclusion results from the Bugey-3 reactor experiment, framed in a minimally extended four-neutrino scenario. Significantly improved constraints on the $\theta_{\mu e}$ mixing angle are derived that constitute the most stringent limits to date over five orders of magnitude in the sterile mass-squared splitting $\Delta m^2_{41}$, excluding the 90% C.L. sterile-neutrino parameter space allowed by the LSND and MiniBooNE observations at 90% CL$_s$ for $\Delta m^2_{41}<5\,$eV$^2$.Furthermore, the LSND and MiniBooNE 99% C.L. allowed regions are excluded at 99% CL$_s$ for $\Delta m^2_{41}$ $<$ 1.2 eV$^2$., Comment: 8 pages, 4 figures

Published
2020
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54. Optical and photoemission investigation of structural and magnetic transitions in the iron-based superconductor Sr$_\mathbf{0.67}$Na$_\mathbf{0.33}$Fe$_\mathbf{2}$As$_\mathbf{2}$

Author

Yang, R., Huang, J. W., Zaki, N., Pletikosic, I., Dai, Y. M., Xiao, H., Valla, T., Johnson, P. D., Zhou, X. J., Qiu, X. G., and Homes, C. C.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

We report the temperature-dependent optical conductivity and ARPES studies of the iron-based superconductor (SC) Sr$_{0.67}$Na$_{0.33}$Fe$_2$As$_2$ in the high-temperature tetragonal paramagnetic phase; below the structural and magnetic transitions at $T_{\rm N}\simeq$125 K in the orthorhombic spin-density-wave (SDW)-like phase, and $T_r\simeq$42 K in the reentrant tetragonal double-Q magnetic phase where both charge and SDW order exist; and below the SC transition at $T_c\simeq$10 K. The free-carrier component in the optical conductivity is described by two Drude contributions; one strong and broad, the other weak and narrow. The broad Drude component decreases dramatically below $T_{\rm N}$ and $T_r$, with much of its strength being transferred to a bound excitation in the mid-infrared, while the narrow Drude component shows no anomalies at either of the transitions, actually increasing in strength at low temperature while narrowing dramatically. The behavior of an infrared-active mode suggests zone-folding below $T_r$. Below $T_c$ the dramatic decrease in the low-frequency optical conductivity signals the formation of a SC energy gap. ARPES reveals hole-like bands at the center of the Brillouin zone (BZ), with both electron- and hole-like bands at the corners. Below $T_{\rm N}$, the hole pockets at the center of the BZ decrease in size, consistent with the behavior of the broad Drude component; while below $T_r$ the electron-like bands shift and split, giving rise to a low-energy excitation in the optical conductivity at ~20 meV. The magnetic states, with resulting SDW and charge-SDW order, respectively, lead to a significant reconstruction of the Fermi surface that has profound implications for the transport originating from the electron and hole pockets, but appears to have relatively little impact on the SC in this material., Comment: 11 pages with 6 figures; 7 pages of supplementary material

Published
2019
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55. Probing for high momentum protons in $^4$He via the $^4He(e,e'p)X$ reaction

Author

Iqbal, S., Benmokhtar, F., Ivanov, M., See, N., Aniol, K., Higinbotham, D. W., Boyd, C., Gadsby, A., Gilad, S., Saha, A., Udias, J. M., Goodwill, J. S., Finton, D., Boyer, A., Ye, Z., Solvignon, P., Aguilera, P., Ahmed, Z., Albataineh, H., Allada, K., Anderson, B., Anez, D., Annand, J., Arrington, J., Averett, T., Baghdasaryan, H., Bai, X., Beck, A., Beck, S., Bellini, V., Camsonne, A., Chen, C., Chen, J. -P., Chirapatpimol, K., Cisbani, E., Dalton, M. M., Daniel, A., Day, D., Deconinck, W., Defurne, M., Flay, D., Fomin, N., Friend, M., Frullani, S., Fuchey, E., Garibaldi, F., Gaskell, D., Gilman, R., Glamazdin, S., Gu, C., Gueye, P., Hanretty, C., Hansen, J. -O., Shabestari, M. Hashemi, Huang, M., Jin, G., Kalantarians, N., Kang, H., Kelleher, A., Korover, I., LeRose, J., Leckey, J., Lindgren, R., Long, E., Mammei, J., Margaziotis, D. J., Markowitz, P., Meekins, D., Meziani, Z., Michaels, R., Mihovilovic, M., Muangma, N., Camacho, C. Munoz, Norum, B., Nuruzzaman, Nuruzzaman, Pan, K., Phillips, S., Piasetzky, E., Pomerantz, I., Posik, M., Punjabi, V., Qian, X., Qiang, Y., Qiu, X., Reimer, P. E., Rakhman, A ., Riordan, S., Ron, G., Rondon-Aramayo, O., Selvy, L., Shahinyan, A., Shneor, R., Sirca, S., Slifer, K., Sparveris, N., Subedi, R., Sulkosky, V., Wang, D., Watson, J. W., Weinstein, L. B., Wojtsekhowski, B., Wood, S. A., Yaron, I., Zhan, X., Zhang, J., Zhang, Y. W., Zhao, B., Zheng, X., Zhu, P., and Zielinski, R.

Subjects
Nuclear Experiment
Abstract

Experimental cross sections for the $^4He(e,e'p)X$ reaction up to a missing momentum of 0.632 GeV/$c$ at $x_B=1.24$ and $Q^2$=2(GeV/$c$)$^2$ are reported. The data are compared to Relativistic Distorted Wave Impulse Approximation(RDWIA) calculations for $^4He(e,e'p)^3H$ channel. Significantly more events in the triton mass region are measured for $p_{m}$$>$0.45 GeV/$c$ than are predicted by the theoretical model, suggesting that the effects of initial-state multi-nucleon correlations are stronger than expected by the RDWIA model., Comment: Submitted to PRC

Published
2019

56. Novel observation of isospin structure of short-range correlations in calcium isotopes

Author

Nguyen, D, Ye, Z, Aguilera, P, Ahmed, Z, Albataineh, H, Allada, K, Anderson, B, Anez, D, Aniol, K, Annand, J, Arrington, J, Averett, T, Baghdasaryan, H, Bai, X, Beck, A, Beck, S, Bellini, V, Benmokhtar, F, Camsonne, A, Chen, C, Chen, JP, Chirapatpimol, K, Cisbani, E, Dalton, MM, Daniel, A, Day, D, Deconinck, W, Defurne, M, Flay, D, Fomin, N, Friend, M, Frullani, S, Fuchey, E, Garibaldi, F, Gaskell, D, Gilad, S, Gilman, R, Glamazdin, S, Gu, C, Guèye, P, Hanretty, C, Hansen, JO, Shabestari, MH, Higinbotham, DW, Huang, M, Iqbal, S, Jin, G, Kalantarians, N, Kang, H, Kelleher, A, Korover, I, Lerose, J, Leckey, J, Li, S, Lindgren, R, Long, E, Mammei, J, Margaziotis, DJ, Markowitz, P, Meekins, D, Meziani, ZE, Michaels, R, Mihovilovic, M, Muangma, N, Camacho, CM, Norum, BE, Nuruzzaman, Pan, K, Phillips, S, Piasetzky, E, Pomerantz, I, Posik, M, Punjabi, V, Qian, X, Qiang, Y, Qiu, X, Reimer, PE, Rakhman, A, Riordan, S, Ron, G, Rondon-Aramayo, O, Saha, A, Selvy, L, Shahinyan, A, Shneor, R, Širca, S, Slifer, K, Solvignon, P, Sparveris, N, Subedi, R, Sulkosky, V, Wang, D, Watson, JW, Weinstein, LB, Wojtsekhowski, B, Wood, SA, Yaron, I, Zhan, X, Zhang, J, and Zhang, YW

Subjects
nucl-ex
Abstract

Short-range correlations (SRCs) have been identified as being responsible for the high-momentum tail of the nucleon momentum distribution, n(k). Hard, short-range interactions of nucleon pairs generate the high-momentum tail and imprint a universal character on n(k) for all nuclei at large momentum. Triple coincidence experiments have shown a strong dominance of np pairs, but these measurements involve large final-state interactions. This paper presents the results from Jefferson Lab experiment E08014 which measured inclusive electron scattering cross section from Ca isotopes. By comparing the inclusive cross section from Ca48 to Ca40 in a kinematic region dominated by SRCs we provide a new way to study the isospin structure of SRCs.

Published
2020

60. Tracking ultrafast photocurrents in the Weyl semimetal TaAs using THz emission spectroscopy

Author

Sirica, N., Tobey, R. I., Zhao, L. X., Chen, G. F., Xu, B., Yang, R., Shen, B., Yarotski, D. A., Bowlan, P., Trugman, S. A., Zhu, J. -X., Dai, Y. M., Azad, A. K., Ni, N., Qiu, X. G., Taylor, A. J., and Prasankumar, R. P.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We investigate polarization-dependent ultrafast photocurrents in the Weyl semimetal TaAs using terahertz (THz) emission spectroscopy. Our results reveal that highly directional, transient photocurrents are generated along the non-centrosymmetric c-axis regardless of incident light polarization, while helicity-dependent photocurrents are excited within the ab-plane. This is consistent with earlier static photocurrent experiments, and demonstrates on the basis of both the physical constraints imposed by symmetry and the temporal dynamics intrinsic to current generation and decay that optically induced photocurrents in TaAs are inherent to the underlying crystal symmetry of the transition metal monopnictide family of Weyl semimetals.

Published
2018
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61. Temperature-driven Topological Phase Transition and Intermediate Dirac Semimetal Phase in ZrTe$_5$

Author

Xu, B., Zhao, L. X., Marsik, P., Sheveleva, E., Lyzwa, F., Dai, Y. M., Chen, G. F., Qiu, X. G., and Bernhard, C.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract

We present an infrared spectroscopy study of ZrTe$_5$, which confirms a recent theoretical proposal that this material exhibits a temperature-driven topological quantum phase transition from a weak to a strong topological insulating state with an intermediate Dirac semimetal state around $T_p \simeq$ 138K. Our study details the temperature evolution of the energy gap in the bulk electronic structure. We found that the energy gap closes around $T_p$ where the optical response exhibits characteristic signatures of a Dirac semimetal state, i.e. a linear frequency-dependent optical conductivity extrapolating to the origin (after subtracting a weak Drude response). This finding allows us to reconcile previous diverging reports about the topological nature of ZrTe$_5$ in terms of a variation of $T_p$ that depends on the crystal growth condition., Comment: 6 pages 3 figures

Published
2018
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62. Scaling of the Fano effect of the in-plane Fe-As phonon and the superconducting critical temperature in Ba$_{1-x}$K$_{x}$Fe$_{2}$As$_{2}$

Author

Xu, B., Cappelluti, E., Benfatto, L., Mallett, B. P. P., Marsik, P., Sheveleva, E., Lyzwa, F., Wolf, Th., Yang, R., Qiu, X. G., Dai, Y. M., Wen, H. H., Lobo, R. P. S. M., and Bernhard, C.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

By means of infrared spectroscopy we determine the temperature-doping phase diagram of the Fano effect for the in-plane Fe-As stretching mode in Ba$_{1-x}$K$_{x}$Fe$_{2}$As$_{2}$. The Fano parameter $1/q^2$, which is a measure of the phonon coupling to the electronic particle-hole continuum, shows a remarkable sensitivity to the magnetic/structural orderings at low temperatures. More strikingly, at elevated temperatures in the paramagnetic/tetragonal state we find a linear correlation between $1/q^2$ and the superconducting critical temperature $T_c$. Based on theoretical calculations and symmetry considerations, we identify the relevant interband transitions that are coupled to the Fe-As mode. In particular, we show that a sizable $xy$ orbital component at the Fermi level is fundamental for the Fano effect and possibly also for the superconducting pairing., Comment: Supplemental materials are available upon request

Published
2018
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63. Proton Form Factor Ratio, $\mu_p G_E^p/G_M^p$ from Double Spin Asymmetry

Author

Liyanage, A., Armstrong, W., Kang, H., Maxwell, J., Mulholland, J., Ndukum, L., Ahmidouch, A., Albayrak, I., Asaturyan, A., Ates, O., Baghdasaryan, H., Boeglin, W., Bosted, P., Brash, E., Butuceanu, C., Bychkov, M., Carter, P., Chen, C., Chen, J-P., Choi, S., Christy, E., Covrig, S., Crabb, D., Danagoulian, S., Daniel, A., Davidenko, A. M., Davis, B., Day, D., Deconinck, W., Deur, A., Dunne, J., Dutta, D., Fassi, L. El, Elaasar, M., Ellis, C., Ent, R., Flay, D., Frlez, E., Gaskell, D., Geagla, O., German, J., Gilman, R., Gogami, T., Gomez, J., Goncharenko, Y. M., Hashimoto, O., Higinbotham, D., Horn, T., Huber, G. M., Jones, M., Jones, M. K., Kalantarians, N., Kang, H-K., Kawama, D., Keppel, C., Khandaker, M., Kim, Y., King, P. M., Kohl, M., Kovacs, K., Kubarovsky, V., Li, Y., Liyanage, N., Mamyan, V., Markowitz, P., Maruta, T., Melnik, Y. M., Meziani, Z-E., Mkrtchyan, A., Mkrtchyan, H., Mochalov, V. V., Monaghan, P., Narayan, A., Nakamura, S. N., Nuruzzaman, Pentchev, L., Pocanic, D., Posik, M., Puckett, A., Qiu, X., Reinhold, J., Riordan, S., Roche, J., Rondo'n, O. A., Sawatzky, B., Shabestari, M., Slifer, K., Smith, G., Soloviev, L. F., Solvignon, P., Tadevosyan, V., Tang, L., Vasiliev, A. N., Veilleux, M., Walton, T., Wesselmann, F., Wood, S. A., Yao, H., Ye, Z., and Zhu, L.

Subjects
Nuclear Experiment
Abstract

The ratio of the electric and magnetic form factor of the proton, $\mu_p G_E^p/G_M^p$, has been measured for elastic electron-proton scattering with polarized beam and target up to four-momentum transfer squared, $Q^2=5.66$ (GeV/c)$^2$ using the double spin asymmetry for target spin orientation aligned nearly perpendicular to the beam momentum direction. This measurement of $\mu_p G_E^p/G_M^p$ agrees with the $Q^2$ dependence of previous recoil polarization data and reconfirms the discrepancy at high $Q^2$ between the Rosenbluth and the polarization-transfer method with a different measurement technique and systematic uncertainties uncorrelated to those of the recoil-polarization measurements. The form factor ratio at $Q^2$=2.06 (GeV/c)$^2$ has been measured as $\mu_p G_E^p/G_M^p = 0.720 \pm 0.176_{stat} \pm 0.039_{sys}$, which is in agreement with an earlier measurement with the polarized target technique at similar kinematics. The form factor ratio at $Q^2$=5.66 (GeV/c)$^2$ has been determined as $\mu_p G_E^p/G_M^p=0.244\pm0.353_{stat}\pm0.013_{sys}$, which represents the highest $Q^2$ reach with the double spin asymmetry with polarized target to date.

Published
2018
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64. Revealing Color Forces with Transverse Polarized Electron Scattering

Author

Armstrong, W., Kang, H., Liyanage, A., Maxwell, J., Mulholland, J., Ndukum, L., Ahmidouch, A., Albayrak, I., Asaturyan, A., Ates, O., Baghdasaryan, H., Boeglin, W., Bosted, P., Brash, E., Butuceanu, C., Bychkov, M., Carter, P., Chen, C., Chen, J. -P., Choi, S., Christy, M. E., Covrig, S., Crabb, D., Danagoulian, S., Daniel, A., Davidenko, A. M., Davis, B., Day, D., Deconinck, W., Deur, A., Dunne, J., Dutta, D., Fassi, L. El, Ellis, C., Ent, R., Flay, D., Frlez, E., Gaskell, D., Geagla, O., German, J., Gilman, R., Gogami, T., Gomez, J., Goncharenko, Y. M., Hashimoto, O., Higinbotham, D., Horn, T., Huber, G. M., Jones, M., Jones, M. K., Kalantarians, N., Kang, H-K., Kawama, D., Keith, C., Keppel, C., Khandaker, M., Kim, Y., King, P. M., Kohl, M., Kovacs, K., Kubarovsky, V., Li, Y., Liyanage, N., Luo, W., Mack, D., Mamyan, V., Markowitz, P., Maruta, T., Meekins, D., Melnik, Y. M., Meziani, Z. -E., Mkrtchyan, A., Mkrtchyan, H., Mochalov, V. V., Monaghan, P., Narayan, A., Nakamura, S. N., Nuruzzaman, A., Pentchev, L., Pocanic, D., Posik, M., Puckett, A., Qiu, X., Reinhold, J., Riordan, S., Roche, J., Rondón, O. A., Sawatzky, B., Shabestari, M., Slifer, K., Smith, G., Soloviev, L. F., Solvignon, P., Tadevosyan, V., Tang, L., Vasiliev, A. N., Veilleux, M., Walton, T., Wesselmann, F., Wood, S., Yao, H., Ye, Z., Zhang, J., and Zhu, L.

Subjects
Nuclear Experiment
Abstract

The Spin Asymmetries of the Nucleon Experiment (SANE) measured two double spin asymmetries using a polarized proton target and polarized electron beam at two beam energies, 4.7 GeV and 5.9 GeV. A large-acceptance open-configuration detector package identified scattered electrons at 40$^{\circ}$ and covered a wide range in Bjorken $x$ ($0.3 < x < 0.8$). Proportional to an average color Lorentz force, the twist-3 matrix element, $\tilde{d}_2^p$, was extracted from the measured asymmetries at $Q^2$ values ranging from 2.0 to 6.0 GeV$^2$. The data display the opposite sign compared to most quark models, including the lattice QCD result, and an apparently unexpected scale dependence. Furthermore when combined with the neutron data in the same $Q^2$ range the results suggest a flavor independent average color Lorentz force.

Published
2018
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65. Probing for high momentum protons in $^4$He via the $^4He(e,e'p)X$ reaction

Author

Iqbal, S, Benmokhtar, F, Ivanov, M, See, N, Aniol, K, Higinbotham, DW, Boyd, C, Gadsby, A, Gilad, S, Saha, A, Udias, JM, Goodwill, JS, Finton, D, Boyer, A, Ye, Z, Solvignon, P, Aguilera, P, Ahmed, Z, Albataineh, H, Allada, K, Anderson, B, Anez, D, Annand, J, Arrington, J, Averett, T, Baghdasaryan, H, Bai, X, Beck, A, Beck, S, Bellini, V, Camsonne, A, Chen, C, Chen, J-P, Chirapatpimol, K, Cisbani, E, Dalton, MM, Daniel, A, Day, D, Deconinck, W, Defurne, M, Flay, D, Fomin, N, Friend, M, Frullani, S, Fuchey, E, Garibaldi, F, Gaskell, D, Gilman, R, Glamazdin, S, Gu, C, Gueye, P, Hanretty, C, Hansen, J-O, Shabestari, M Hashemi, Huang, M, Jin, G, Kalantarians, N, Kang, H, Kelleher, A, Korover, I, LeRose, J, Leckey, J, Lindgren, R, Long, E, Mammei, J, Margaziotis, DJ, Markowitz, P, Meekins, D, Meziani, Z, Michaels, R, Mihovilovic, M, Muangma, N, Camacho, C Munoz, Norum, B, Nuruzzaman, Nuruzzaman, Pan, K, Phillips, S, Piasetzky, E, Pomerantz, I, Posik, M, Punjabi, V, Qian, X, Qiang, Y, Qiu, X, Reimer, PE, Rakhman, A, Riordan, S, Ron, G, Rondon-Aramayo, O, Selvy, L, Shahinyan, A, Shneor, R, Sirca, S, Slifer, K, Sparveris, N, Subedi, R, Sulkosky, V, Wang, D, Watson, JW, and Weinstein, LB

Subjects
nucl-ex
Abstract

Experimental cross sections for the $^4He(e,e'p)X$ reaction up to a missingmomentum of 0.632 GeV/$c$ at $x_B=1.24$ and $Q^2$=2(GeV/$c$)$^2$ are reported.The data are compared to Relativistic Distorted Wave ImpulseApproximation(RDWIA) calculations for $^4He(e,e'p)^3H$ channel. Significantlymore events in the triton mass region are measured for $p_{m}$$>$0.45 GeV/$c$than are predicted by the theoretical model, suggesting that the effects ofinitial-state multi-nucleon correlations are stronger than expected by theRDWIA model.

Published
2019

68. Supplementing pigeon grit with acidifier improves metabolism and the reproductive performance of breeding pigeons as well as the development of growth performance of squabs.

Author

Zheng, S., Tang, Y., Huang, W., Zhang, W., Zhang, Y., Yang, M., Lu, H., Li, Z., He, Y., Qiu, X., Liu, Y., Gou, Z., Qiu, Z., Bin, Y., Zhang, Z., Gao, H., Wang, W., Peng, J., Huang, Y., and Liang, Y.

Subjects
WEIGHT loss, MEAT quality, PIGEONS, BODY weight, EXPERIMENTAL groups
Abstract

1. This study evaluated the effectiveness of different types of acidifiers on reproductive performance, body weight loss and plasma biochemical indices of breeding pigeons as well as on growth performance, carcass characteristics, meat quality and plasma biochemical indices of squabs. 2. In a 45 d trial, 144 pairs of European white Mimas pigeons were selected and randomly divided into three experimental groups. Three groups of pigeons were fed plain pigeon grit (NC), pigeon grit supplemented with 5% single acidifier (SAG) and pigeon grit supplemented with 5% combined acidifiers (CAG). 3. Supplementing with SAG and CAG significantly increased the weight gain in male pigeons from 1-12 d of incubation. However, SAG and CAG had no significant effect on the feed intake of breeding pigeons during incubation, but significantly increased total feed intake of breeding pigeons during the lactation period. Breeder pigeons fed SAG and CAG had significantly higher egg-laying rate at 40 d. In addition, feeding SAG and CAG significantly increased growth rate and slaughter weight of squabs, but SAG reduced the diameter of pectoral muscle fibres. Biochemical indices showed that feeding SAG and CAG improved metabolism and increased the liver function of breeder pigeons and squabs. 4. In conclusion, supplementing pigeon grit with acidifiers increased feed intake of breeding pigeons during lactation, protected liver function, enhanced reproductive performance and promoted the growth and development of squabs. HIGHLIGHTS: Supplementation with single acidifier and combined acidifier is healthy for both breeding pigeons and squabs. Supplementation with single acidifier and combined acidifier can improve the egg-laying rate of breeding pigeons. Supplementation with single acidifier and combined acidifier can improve the growth rate of squabs. Supplementation single acidifier and combined acidifier helps to protect the liver and reduce liver damage of breeding pigeons and squabs [ABSTRACT FROM AUTHOR]

Published
2025
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69. Search for three-nucleon short-range correlations in light nuclei

Author

Ye, Z., Solvignon, P., Nguyen, D., Aguilera, P., Ahmed, Z., Albataineh, H., Allada, K., Anderson, B., Anez, D., Aniol, K., Annand, J., Arrington, J., Averett, T., Baghdasaryan, H., Bai, X., Beck, A., Beck, S., Bellini, V., Benmokhtar, F., Camsonne, A., Chen, C., Chen, J. -P., Chirapatpimol, K., Cisbani, E., Dalton, M. M., Daniel, A., Day, D., Deconinck, W., Defurne, M., Flay, D., Fomin, N., Friend, M., Frullani, S., Fuchey, E., Garibaldi, F., Gaskell, D., Gilad, S., Gilman, R., Glamazdin, S., Gu, C., Gueye, P., Hanretty, C., Hansen, J. -O., Shabestari, M. Hashemi, Higinbotham, D. W., Huang, M., Iqbal, S., Jin, G., Kalantarians, N., Kang, H., Kelleher, A., Korover, I., LeRose, J., Leckey, J., Lindgren, R., Long, E., Mammei, J., Margaziotis, D. J., Markowitz, P., Meekins, D., Meziani, Z., Michaels, R., Mihovilovic, M., Muangma, N., Camacho, C. Munoz, Norum, B., Nuruzzaman, Pan, K., Phillips, S., Piasetzky, E., Pomerantz, I., Posik, M., Punjabi, V., Qian, X., Qiang, Y., Qiu, X., Reimer, P. E., Rakhman, A., Riordan, S., Ron, G., Rondon-Aramayo, O., Saha, A., Selvy, L., Shahinyan, A., Shneor, R., Sirca, S., Slifer, K., Sparveris, N., Subedi, R., Sulkosky, V., Wang, D., Watson, J. W., Weinstein, L. B., Wojtsekhowski, B., Wood, S. A., Yaron, I., Zhan, X., Zhang, J., Zhang, Y. W., Zhao, B., Zheng, X., Zhu, P., and Zielinski, R.

Subjects
Nuclear Experiment
Abstract

We present new data probing short-range correlations (SRCs) in nuclei through the measurement of electron scattering off high-momentum nucleons in nuclei. The inclusive 4He/3He cross section ratio is observed to be both x and Q2 independent for 1.5 < x < 2, confirming the dominance of two- nucleon (2N) short-range correlations (SRCs). For x > 2, our data do not support a previous claim of three-nucleon (3N) correlation dominance. While contributions beyond those from stationary 2N- SRCs are observed, our data show that isolating 3N-SRCs is more complicated than for 2N-SRCs., Comment: 6 pages, 2 figures, new experimental results from JLab E08-014

Published
2017
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70. Design and Performance of the Spin Asymmetries of the Nucleon Experiment

Author

Maxwell, J. D., Armstrong, W. R., Choi, S., Jones, M. K., Kang, H., Liyanage, A., Meziani, Z. -E., Mulholland, J., Ndukum, L., Rondon, O. A., Ahmidouch, A., Albayrak, I., Asaturyan, A., Ates, O., Baghdasaryan, H., Boeglin, W., Bosted, P., Brash, E., Brock, J., Butuceanu, C., Bychkov, M., Carlin, C., Carter, P., Chen, C., Chen, J. -P., Christy, M. E., Covrig, S., Crabb, D., Danagoulian, S., Daniel, A., Davidenko, A. M., Davis, B., Day, D., Deconinck, W., Deur, A., Dunne, J., Dutta, D., Fassi, L. El, Elaasar, M., Ellis, C., Ent, R., Flay, D., Frlez, E., Gaskell, D., Geagla, O., German, J., Gilman, R., Gogami, T., Gomez, J., Goncharenko, Y. M., Hashimoto, O., Higinbotham, D. W., Horn, T., Huber, G. M., Jones, M., Kalantarians, N., Kang, H. K., Kawama, D., Keith, C., Keppel, C., Khandaker, M., Kim, Y., King, P. M., Kohl, M., Kovacs, K., Kubarovsky, V., Li, Y., Liyanage, N., Luo, W., Mamyan, V., Markowitz, P., Maruta, T., Meekins, D., Melnik, Y. M., Mkrtchyan, A., Mkrtchyan, H., Mochalov, V. V., Monaghan, P., Narayan, A., Nakamura, S. N., Nuruzzaman, Pentchev, L., Pocanic, D., Posik, M., Puckett, A., Qiu, X., Reinhold, J., Riordan, S., Roche, J., Sawatzky, B., Shabestari, M., Slifer, K., Smith, G., Soloviev, L., Solvignon, P., Tadevosyan, V., Tang, L., Vasiliev, A. N., Veilleux, M., Walton, T., Wesselmann, F., Wood, S. A., Yao, H., Ye, Z., and Zhu, L.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The Spin Asymmetries of the Nucleon Experiment (SANE) performed inclusive, double-polarized electron scattering measurements of the proton at the Continuous Electron Beam Accelerator Facility at Jefferson Lab. A novel detector array observed scattered electrons of four-momentum transfer $2.5 < Q^2< 6.5$ GeV$^2$ and Bjorken scaling $0.3

Published
2017
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71. Search for sterile neutrinos in MINOS and MINOS+ using a two-detector fit

Author

Adamson, P., Anghel, I., Aurisano, A., Barr, G., Bishai, M., Blake, A., Bock, G. J., Bogert, D., Cao, S. V., Carroll, T. J., Castromonte, C. M., Chen, R., Childress, S., Coelho, J. A. B., Corwin, L., Cronin-Hennessy, D., de Jong, J. K., De Rijck, S., Devan, A. V., Devenish, N. E., Diwan, M. V., Escobar, C. O., Evans, J. J., Falk, E., Feldman, G. J., Flanagan, W., Frohne, M. V., Gabrielyan, M., Gallagher, H. R., Germani, S., Gomes, R. A., Goodman, M. C., Gouffon, P., Graf, N., Gran, R., Grzelak, K., Habig, A., Hahn, S. R., Hartnell, J., Hatcher, R., Holin, A., Huang, J., Hylen, J., Irwin, G. M., Isvan, Z., James, C., Jensen, D., Kafka, T., Kasahara, S. M. S., Koerner, L. W., Koizumi, G., Kordosky, M., Kreymer, A., Lang, K., Ling, J., Litchfield, P. J., Lucas, P., Mann, W. A., Marshak, M. L., Mayer, N., McGivern, C., Medeiros, M. M., Mehdiyev, R., Meier, J. R., Messier, M. D., Miller, W. H., Mishra, S. R., Sher, S. Moed, Moore, C. D., Mualem, L., Musser, J., Naples, D., Nelson, J. K., Newman, H. B., Nichol, R. J., Nowak, J. A., O'Connor, J., Orchanian, M., Pahlka, R. B., Paley, J., Patterson, R. B., Pawloski, G., Perch, A., Pfützner, M. M., Phan, D. D., Phan-Budd, S., Plunkett, R. K., Poonthottathil, N., Qiu, X., Radovic, A., Rebel, B., Rosenfeld, C., Rubin, H. A., Sail, P., Sanchez, M. C., Schneps, J., Schreckenberger, A., Schreiner, P., Sharma, R., Sousa, A., Tagg, N., Talaga, R. L., Thomas, J., Thomson, M. A., Tian, X., Timmons, A., Todd, J., Tognini, S. C., Toner, R., Torretta, D., Tzanakos, G., Urheim, J., Vahle, P., Viren, B., Weber, A., Webb, R. C., White, C., Whitehead, L. H., Wojcicki, S. G., and Zwaska, R.

Subjects
High Energy Physics - Experiment
Abstract

A search for mixing between active neutrinos and light sterile neutrinos has been performed by looking for muon neutrino disappearance in two detectors at baselines of 1.04 km and 735 km, using a combined MINOS and MINOS+ exposure of $16.36\times10^{20}$ protons-on-target. A simultaneous fit to the charged-current muon neutrino and neutral-current neutrino energy spectra in the two detectors yields no evidence for sterile neutrino mixing using a 3+1 model. The most stringent limit to date is set on the mixing parameter $\sin^2\theta_{24}$ for most values of the sterile neutrino mass-splitting $\Delta m^2_{41} > 10^{-4}$ eV$^2$., Comment: 7 pages, 4 figures, additional analysis details and a data release in the ancillary materials

Published
2017
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72. Infrared probe of the gap evolution across the phase diagram of Ba$_{1-x}$K$_{x}$Fe$_{2}$As$_{2}$

Author

Xu, B., Dai, Y. M., Xiao, H., Shen, B., Wen, H. H., Qiu, X. G., and Lobo, R. P. S. M.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

We measured the optical conductivity of superconducting single crystals of Ba$_{1-x}$K$_{x}$Fe$_{2}$As$_{2}$ with $x$ ranging from 0.40 (optimal doping, $T_c = 39$ K) down to 0.20 (underdoped, $T_c = 16$ K), where a magnetic order coexists with superconductivity. In the normal state, the low-frequency optical conductivity can be described by an incoherent broad Drude component and a coherent narrow Drude component: the broad one is doping-independent, while the narrow one shows strong scattering in the heavily underdoped compound. In the superconducting state, the formation of the condensate leads to a low-frequency suppression of the optical conductivity spectral weight. In the heavily underdoped region, the superfluid density is significantly suppressed, and the weight of unpaired carriers rapidly increases. We attribute these results to changes in the superconducting gap across the phase diagram, which could show a nodal-to-nodeless transition due to the strong interplay between magnetism and superconductivity in underdoped Ba$_{1-x}$K$_{x}$Fe$_{2}$As$_{2}$.

Published
2017
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73. The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique [Corrigendum]

Author

Wang H, Zhou C, Su Y, Gou K, Geng X, and Qiu X

Subjects
itraconazole, voriconazole, ripretinib, uplc-ms/ms, pharmacokinetics, beagle dog, Therapeutics. Pharmacology, RM1-950
Abstract

Wang H, Zhou C, Su Y, Gou K, Geng X, Qiu X. Drug Des Devel Ther. 2021;15:4865–4873. The authors have informed the journal that ripretinib was used in this study, not erdafitinib as indicated in parts of the paper. Namely, on page 4865, Abstract, Results section; page 4868, Animal Experiments and Pharmacokinetics Study sections; page 4872, Pharmacokinetics Effects and Conclusions sections. The authors have also advised on page 4867, Materials and Methods, Chemicals Materials section, third line from the bottom, the text “Itraconazole” should read “voriconazole”. The authors apologize for any confusion this may have caused.

Published
2023

75. Nomogram for Persistent Post-Stroke Depression and Decision Curve Analysis

Author

Lan Y, Pan C, Qiu X, Miao J, Sun W, Li G, Zhao X, Zhu Z, and Zhu S

Subjects
persistent post-stroke depression, nomogram, decision curve analysis, Geriatrics, RC952-954.6
Abstract

Yan Lan, Chensheng Pan, Xiuli Qiu, Jinfeng Miao, Wenzhe Sun, Guo Li, Xin Zhao, Zhou Zhu, Suiqiang Zhu Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Zhou Zhu; Suiqiang Zhu, Tel +86-18171081029 ; +86-13035101141, Email zhouzhu@hust.edu.cn; zhusuiqiang@163.comPurpose: Previous studies have shown that persistent post-stroke depression (PSD) was associated with unfavorable prognosis. The aim of this multicenter prospective study was to investigate the predictors associated with persistent PSD, develop a nomogram and validate its clinical usefulness by decision curve analysis (DCA).Patients and Methods: A total of 875 acute ischemic stroke patients from four hospitals were consecutively recruited and completed 1-year follow-ups. Sociodemographic indicators, vascular risk factors, clinical information, serum biochemical indicators and cytokines were collected on admission. The functional outcome was assessed at 1 year after stroke. Persistent depression was defined as having a presentation of depression at each follow-up points and the depressive symptoms occurring persistently since the diagnosis of depression.Results: There were 513 patients who experienced PSD during the 1-year follow-up, the cumulative incidence of PSD within 1 year was 58.6%. Persistent PSD was recorded in 289 patients, of which 59 (20.4%) result in unfavorable outcomes. The risk factors of persistent PSD in 1 year after stroke were the Hamilton Depression Scale-17 items (HAMD-17) score at admission, serum direct bilirubin and free serum thyroxine (FT4) level and activated partial thromboplastin time (APTT). Nomogram conducted based on these factors has a C-index (± standard deviation) of 0.655 ± 0.039, and the DCA demonstrated that the nomogram had a favorable clinical utility.Conclusion: We found that persistent depression after stroke in the first-year time course after stroke was associated with HAMD-17 score at admission, lower serum direct bilirubin and FT4 level, and APTT. A nomogram was developed with advisable clinical usefulness in our study.Keywords: persistent post-stroke depression, nomogram, decision curve analysis

Published
2022

76. NIR-II Fluorescence Imaging Using Indocyanine Green Provides Early Prediction of Skin Avulsion-Injury in a Porcine Model

Author

Gao S, Yu Y, Wang Z, Wu Y, Qiu X, Jian C, and Yu A

Subjects
icg, near-infrared fluorescence imaging, skin avulsion injury, swine model, Dermatology, RL1-803
Abstract

Siqi Gao,&ast; Yifeng Yu,&ast; Zheng Wang, Yifan Wu, Xingan Qiu, Chao Jian, Aixi Yu Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Aixi Yu; Chao Jian, Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, People’s Republic of China, Tel +86-27-6781-3120 ; +86-27-6781-3120, Email yuaixi@whu.edu.cn; chaojian@whu.edu.cnPurpose: Currently, skin avulsion–injury reconstruction is mainly based on subjective evaluation of traditional clinical signs. It frequently results in unnecessary tissue loss and incomplete debridement-related infection. This pilot study aimed to develop a novel near-infrared (NIR) II fluorescence imaging method to assess avulsed skin–perfusion status and thus predict its outcome early.Methods: Skin avulsion–injury models were established by avulsing 10× 4 cm pedicled flaps on porcine hindlimbs. A clinically available improved NIR-&Igr;/II multispectral imaging system was applied for NIR imaging using indocyanine green (ICG) fluorescence. Continuous NIR-wavelength filters and dynamic imaging were used to investigate optimal imaging conditions and time window. NIR-&Igr;/II imaging was synchronously conducted for quality comparison of the two methods. Visual inspection and histological studies were used for assessing the final outcome of avulsed skin.Results: NIR-II fluorescence imaging with a 1,100 nm filter obtained satisfactory performance and reached maximum fluorescence intensity at 1 minute after ICG injection. NIR-II imaging clearly visualized the microvascular network in vascularized avulsed skin and revealed “dark areas” in nonvascularized avulsed skin in a real-time fashion. NIR-II fluorescence imaging demonstrated higher resolution than NIR-I imaging, as indicated by ae higher signal-to-background ratio (2.11) and lower full width at half maximum (6.50614). The dark area of avulsed skin on imaging finally developed to necroses that were confirmed by histology.Conclusion: NIR-II real-time fluorescence imaging clearly maps the microvascular network and shows the perfusion status of avulsed skin at higher resolution than traditional NIR-I imaging, and thus precisely predicts the outcome of avulsed skin early.Keywords: ICG, near-infrared fluorescence imaging, skin avulsion-injury, swine model

Published
2022

77. Search for three-nucleon short-range correlations in light nuclei

Author

Ye, Z, Solvignon, P, Nguyen, D, Aguilera, P, Ahmed, Z, Albataineh, H, Allada, K, Anderson, B, Anez, D, Aniol, K, Annand, J, Arrington, J, Averett, T, Baghdasaryan, H, Bai, X, Beck, A, Beck, S, Bellini, V, Benmokhtar, F, Camsonne, A, Chen, C, Chen, JP, Chirapatpimol, K, Cisbani, E, Dalton, MM, Daniel, A, Day, D, Deconinck, W, Defurne, M, Flay, D, Fomin, N, Friend, M, Frullani, S, Fuchey, E, Garibaldi, F, Gaskell, D, Gilad, S, Gilman, R, Glamazdin, S, Gu, C, Guèye, P, Hanretty, C, Hansen, JO, Shabestari, MH, Higinbotham, DW, Huang, M, Iqbal, S, Jin, G, Kalantarians, N, Kang, H, Kelleher, A, Korover, I, Lerose, J, Leckey, J, Lindgren, R, Long, E, Mammei, J, Margaziotis, DJ, Markowitz, P, Meekins, D, Meziani, Z, Michaels, R, Mihovilovic, M, Muangma, N, Camacho, CM, Norum, B, Nuruzzaman, Pan, K, Phillips, S, Piasetzky, E, Pomerantz, I, Posik, M, Punjabi, V, Qian, X, Qiang, Y, Qiu, X, Reimer, PE, Rakhman, A, Riordan, S, Ron, G, Rondon-Aramayo, O, Saha, A, Selvy, L, Shahinyan, A, Shneor, R, Sirca, S, Slifer, K, Sparveris, N, Subedi, R, Sulkosky, V, Wang, D, Watson, JW, Weinstein, LB, Wojtsekhowski, B, Wood, SA, Yaron, I, Zhan, X, Zhang, J, Zhang, YW, and Zhao, B

Subjects
nucl-ex
Abstract

We present new data probing short-range correlations (SRCs) in nuclei through the measurement of electron scattering off high-momentum nucleons in nuclei. The inclusive He4/He3 cross section ratio is observed to be both x and Q2 independent for 1.52, our data support the hypothesis that a previous claim of three-nucleon correlation dominance was an artifact caused by the limited resolution of the measurement. While 3N-SRCs appear to have an important contribution, our data show that isolating 3N-SRCs is significantly more complicated than for 2N-SRCs.

Published
2018

79. Development and Validation of a Nomogram to Assist Monitoring Nosocomial SARS-CoV-2 Infection of Hospitalized Patients

Author

Wang C, Peng C, Ning L, Qiu X, Wu K, Yang N, Jin B, Zhao Y, and Zheng F

Subjects
covid-19, nomogram, nosocomial sars-cov-2 infection, machine learning, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Chen Wang,1,&ast; Chunyan Peng,2,&ast; Leping Ning,3,&ast; Xueping Qiu,1 Kaisong Wu,4 Na Yang,1 Bingyu Jin,1 Yue Zhao,1 Fang Zheng1 1Center for Gene Diagnosis, Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China; 2Department of Laboratory Medicine, Taihe hospital, Hubei University of Medicine, Shiyan, Hubei, People’s Republic of China; 3Department of Laboratory Medicine, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People’s Republic of China; 4Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Fang Zheng, Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, People’s Republic of China, Tel +86-27-67813233, Fax +86 27 67813497, Email zhengfang@whu.edu.cnPurpose: SARS-CoV-2 is extremely infectious, and the incidence of nosocomial infection is conceivably high. We aimed to develop and validate a nomogram to assist monitoring nosocomial SARS-CoV-2 infection in hospitalized patients.Patients and Methods: There were 437 COVID-19 hospitalized cases and 420 negative inpatients enrolled from two hospitals in Hubei province, China. We compared the demographic and clinical characteristics of participants between the two groups. Then, LASSO regression and logistic regression were applied to build a nomogram for SARS-CoV-2 infection prediction in the development cohort. Our nomogram was assessed by area under the curve (AUC), calibration curve, decision curve (DCA) and clinical impact curve analysis (CICA).Results: After LASSO regression filtration, eleven laboratory indicators were correlated with SARS-CoV-2 infection. Then, we integrated these features and constructed a nomogram, which showed a high AUC 0.863 (95% CI: 0.834– 0.892) in the development cohort with a sensitivity of 80.41% and specificity of 77.38% and 0.813 (95% CI: 0.760– 0.866) in validation cohort with a sensitivity of 82.98% and specificity of 70.43%. The calibration plot displayed that the predicted outcomes were in good concordance with the actual observations. DCA and CICA further showed a larger clinical net benefit.Conclusion: We constructed and validated a nomogram that integrated eleven laboratory indexes to assist monitoring of nosocomial SARS-CoV-2 infection in hospitalized patients. Our nomogram is remarkably informative for clinical practice, which will be helpful for preventing SARS-CoV-2 further transmission in hospital and avoiding nosocomial infection.Graphical Abstract: Keywords: COVID-19, nomogram, nosocomial SARS-CoV-2 infection, machine learning

Published
2022

80. Hybrid Cell Membrane-Functionalized Biomimetic Nanoparticles for Targeted Therapy of Osteosarcoma

Author

Cai J, Liu J, Wu J, Li Y, Qiu X, Xu W, Xu P, and Xiang D

Subjects
biomimetic nano-drug delivery system, osteosarcoma, paclitaxel, targeted therapy, Medicine (General), R5-920
Abstract

Jia-Xin Cai,1– 3,&ast; Ji-Hua Liu,1– 3,&ast; Jun-Yong Wu,1– 3 Yong-Jiang Li,1– 3 Xiao-Han Qiu,1– 3 Wen-Jie Xu,1– 3 Ping Xu,1,2 Da-Xiong Xiang1– 3 1Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People’s Republic of China; 2Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, People’s Republic of China; 3Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug, Changsha, Hunan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ping Xu; Da-Xiong Xiang, Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People’s Republic of China, Email xuping1109@csu.edu.cn; xiangdaxiong@csu.edu.cnPurpose: In order to prepare a biomimetic nano-carrier which has inflammatory chemotaxis, homologous targeting and reduce immune clearance, for targeted chemotherapy of osteosarcoma, we fabricated the paclitaxel-loaded poly(lactic-co-glycolic) acid (PLGA) nanoparticles coated with 143B-RAW hybrid membrane (PTX-PLGA@[143B-RAW] NPs) and evaluate its anti-cancer efficacy in vitro and vivo.Methods: PTX-PLGA@[143B-RAW] NPs were prepared by the ultrasonic method and were characterized by size, zeta potential, polymer dispersion index (PDI), Coomassie bright blue staining, transmission electron microscopy (TEM) and high performance liquid chromatography (HPLC). Cellular uptake, cell viability assay, flow cytometry and chemotactic effect of PTX-PLGA@[143B-RAW] NPs were evaluated in vitro. Biodistribution, anti-cancer therapeutic efficacy and safety of PTX-PLGA@[143B-RAW] NPs were evaluated in 143B osteosarcoma xenograft mice.Results: The hybrid membrane successfully coated onto the surface of PLGA nanoparticles. PTX-PLGA@[143B-RAW] NPs had a drug loading capacity of 4.24 ± 0.02% and showed targeting ability to osteosarcoma. PTX-PLGA@[143B-RAW] NPs showed high cellular uptake and improved anti-cancer efficacy against 143B cells. More importantly, PTX-PLGA@[143B-RAW] NPs treatment suppressed tumor growth in tumor-bearing mice with minimal damage to normal tissues.Conclusion: PTX-PLGA@[143B-RAW] NPs could be used for targeted drug delivery and osteosarcoma therapy.Keywords: biomimetic nano-drug delivery system, osteosarcoma, paclitaxel, targeted therapy

Published
2022

81. Identification of m6A-Associated Gene DST as a Prognostic and Immune-Associated Biomarker in Breast Cancer Patients

Author

Qiu X, Li X, Yan Y, Cai Y, Liang Q, Peng B, Xu Z, Xiao M, Xia F, and Peng J

Subjects
breast cancer, dst, n6-methyladenosine, immune microenvironment, immune infiltration., Medicine (General), R5-920
Abstract

Xiangyuan Qiu,1 Xinying Li,1 Yuanliang Yan,2 Yuan Cai,3 Qiuju Liang,2 Bi Peng,3 Zhijie Xu,3– 5 Muzhang Xiao,6 Fada Xia,1 Jinwu Peng3,4 1Department of Thyroid Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People’s Republic of China; 2Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People’s Republic of China; 3Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People’s Republic of China; 4Department of Pathology, Xiangya Changde Hospital, Changde, 415000, Hunan, People’s Republic of China; 5National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People’s Republic of China; 6Department of Burn and Plastic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People’s Republic of ChinaCorrespondence: Muzhang XiaoDepartment of Burn and Plastic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People’s Republic of ChinaEmail xmzsir@sina.comFada XiaDepartment of Thyroid Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People’s Republic of ChinaEmail xiafada@csu.edu.cnBackground: N6-methyladenosine (m6A) is most common internal RNA modification in eukaryotic cells. Existing evidence shows that m6A is closely related to pathogenesis and progression in breast cancer (BRCA). Therefore, it is critical to investigate the key role of m6A target genes in BRCA.Methods: M6A target genes in BRCA are acquired using RMVar online database. The differentially expressed genes (DEGs) from three microarray datasets (GSE5764, GSE22358, GSE9014) is processed by GEO2R. Oncomine, GEPIA, UALCAN and TNMplot were applied to validate the expression of DST. Survival analyses were performed via DRUGSURV and Kaplan–Meier Plotter database. Univariable survival and multivariate Cox analysis were completed to assess the prognostic value of DST and receiver operating characteristic (ROC) curve was performed to evaluate the diagnostic value of DST. We also investigated the correlation between DST and cancer immune infiltration via using CIBERSORT, TIMER and TISIDB.Results: DST and COL11A1 were significantly expressed in both DEGs and m6A target genes set. COL11A1 show no significance on the patients’ survival. However, high expression of DST was related to the favorable prognosis. Multivariate analysis revealed that the DST dysregulation is an independent prognostic factor and ROC indicated that the great diagnostic value of DST with AUC of 0.948. Subsequently, immunological analyses showed that DST was significantly associated with various immune infiltration cells, including NK cells, T helper cells and Mast cells. Furthermore, DST was also related with multiple immune checkpoints and chemokines, including LAG3, LMTK3 CD24, CXCL12, KDR and CX3CR1. These results indicated the potential roles of DST in the development of BRCA via altering the immune response.Conclusion: DST can influence the development and progression of BRCA by altering the immune microenvironment.Keywords: breast cancer, DST, N6-methyladenosine, immune microenvironment, immune infiltration

Published
2022

82. Higher Serum Lactic Dehydrogenase is Associated with Post-Stroke Depression at Discharge

Author

Li G, Miao J, Pan C, Jing P, Chen G, Mei J, Sun W, Lan Y, Zhao X, Qiu X, Wang Y, Zhu Z, Zhu S, and Lian L

Subjects
post-stroke depression, lactic dehydrogenase, screen, cohort study, Geriatrics, RC952-954.6
Abstract

Guo Li,1 Jinfeng Miao,1 Chensheng Pan,1 Ping Jing,2 Guohua Chen,3 Junhua Mei,3 Wenzhe Sun,1 Yan Lan,1 Xin Zhao,1 Xiuli Qiu,1 Yanyan Wang,1 Zhou Zhu,1 Suiqiang Zhu,1 Lifei Lian1 1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China; 2Department of Neurology, Wuhan Central Hospital, Wuhan, Hubei, 430014, People’s Republic of China; 3Department of Neurology, Wuhan First Hospital, Wuhan, Hubei, 430022, People’s Republic of ChinaCorrespondence: Lifei Lian Tel +86-151 7150 7263Email 47009189@qq.comPurpose: Post-stroke depression (PSD) is one of the most common and severe psychological sequelae after stroke, negatively affecting the patient’s functional outcome and quality of life. Rapidly measurable biomarkers to predict PSD are pivotal for the optimized care and allocation of healthcare resources. Lactic dehydrogenase (LDH) levels are increased in patients with central nervous system (CNS) disorders such as cerebral infarction and hypoxic–ischemic encephalopathy, which may be related to the occurrence of PSD in acute ischemic stroke (AIS) patients. This study aimed to investigate whether LDH levels on admission are associated with PSD at discharge.Patients and Methods: A multicenter prospective cohort study was conducted, including all consecutive AIS patients within 7 days after symptom onset from May 2018 to October 2019. According to the distribution of LDH and the number of patients, patients were divided into equal tertiles. PSD was evaluated by DSM-V criteria and the 17-item Hamilton Rating Scale for Depression (HRSD-17) at discharge.Results: A total of 518 AIS patients were included. The optimal cut-off points of LDH were: lowest tertile (T1) 102– 159/L, middle tertile (T2) 160– 189 U/L, and upper tertile (T3) 190– 520 U/L. A total of 249 patients (48.07%) were diagnosed with PSD at discharge. After adjusting for potential confounding factors, the odds ratio of T3 PSD was 1.698 (95% CI, 1.070– 2.694, P=0.025), compared with T1.Conclusion: In summary, LDH serum levels on admission are associated with PSD at discharge. Clinicians should pay more attention to the baseline LDH level in screening for PSD at discharge.Keywords: post-stroke depression, lactic dehydrogenase, screen, cohort study

Published
2021

83. Temperature-tunable Fano resonance induced by strong coupling between Weyl fermions and phonons in TaAs

Author

Xu, B., Dai, Y. M., Zhao, L. X., Wang, K., Yang, R., Zhang, W., Liu, J. Y., Xiao, H., Chen, G. F., Trugman, S. A., Zhu, J. -X., Taylor, A. J., Yarotski, D. A., Prasankumar, R. P., and Qiu, X. G.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

Strong coupling between discrete phonon and continuous electron-hole pair excitations can give rise to a pronounced asymmetry in the phonon line shape, known as the Fano resonance. This effect has been observed in a variety of systems, such as stripe-phase nickelates, graphene and high-$T_{c}$ superconductors. Here, we reveal explicit evidence for strong coupling between an infrared-active $A_1$ phonon and electronic transitions near the Weyl points (Weyl fermions) through the observation of a Fano resonance in the recently discovered Weyl semimetal TaAs. The resultant asymmetry in the phonon line shape, conspicuous at low temperatures, diminishes continuously as the temperature increases. This anomalous behavior originates from the suppression of the electronic transitions near the Weyl points due to the decreasing occupation of electronic states below the Fermi level ($E_{F}$) with increasing temperature, as well as Pauli blocking caused by thermally excited electrons above $E_{F}$. Our findings not only elucidate the underlying mechanism governing the tunable Fano resonance, but also open a new route for exploring exotic physical phenomena through the properties of phonons in Weyl semimetals., Comment: 16 pages, 3 figures

Published
2016
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84. Constraints on Large Extra Dimensions from the MINOS Experiment

Author

Adamson, P., Anghel, I., Aurisano, A., Barr, G., Bishai, M., Blake, A., Bock, G. J., Bogert, D., Cao, S. V., Carroll, T. J., Castromonte, C. M., Chen, R., Childress, S., Coelho, J. A. B., Corwin, L., Cronin-Hennessy, D., de Jong, J. K., De Rijck, S., Devan, A. V., Devenish, N. E., Diwan, M. V., Escobar, C. O., Evans, J. J., Falk, E., Feldman, G. J., Flanagan, W., Frohne, M. V., Gabrielyan, M., Gallagher, H. R., Germani, S., Gomes, R. A., Goodman, M. C., Gouffon, P., Graf, N., Gran, R., Grzelak, K., Habig, A., Hahn, S. R., Hartnell, J., Hatcher, R., Holin, A., Huang, J., Hylen, J., Irwin, G. M., Isvan, Z., James, C., Jensen, D., Kafka, T., Kasahara, S. M. S., Koizumi, G., Kordosky, M., Kreymer, A., Lang, K., Ling, J., Litchfield, P. J., Lucas, P., Mann, W. A., Marshak, M. L., Mayer, N., McGivern, C., Medeiros, M. M., Mehdiyev, R., Meier, J. R., Messier, M. D., Miller, W. H., Mishra, S. R., Sher, S. Moed, Moore, C. D., Mualem, L., Musser, J., Naples, D., Nelson, J. K., Newman, H. B., Nichol, R. J., Nowak, J. A., O'Connor, J., Orchanian, M., Pahlka, R. B., Paley, J., Patterson, R. B., Pawloski, G., Perch, A., Pfützner, M. M., Phan, D. D., Phan-Budd, S., Plunkett, R. K., Poonthottathil, N., Qiu, X., Radovic, A., Rebel, B., Rosenfeld, C., Rubin, H. A., Sail, P., Sanchez, M. C., Schneps, J., Schreckenberger, A., Schreiner, P., Sharma, R., Sousa, A., Tagg, N., Talaga, R. L., Thomas, J., Thomson, M. A., Tian, X., Timmons, A., Todd, J., Tognini, S. C., Toner, R., Torretta, D., Tzanakos, G., Urheim, J., Vahle, P., Viren, B., Weber, A., Webb, R. C., White, C., Whitehead, L., Whitehead, L. H., Wojcicki, S. G., and Zwaska, R.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We report new constraints on the size of large extra dimensions from data collected by the MINOS experiment between 2005 and 2012. Our analysis employs a model in which sterile neutrinos arise as Kaluza-Klein states in large extra dimensions and thus modify the neutrino oscillation probabilities due to mixing between active and sterile neutrino states. Using Fermilab's NuMI beam exposure of $10.56 \times 10^{20}$ protons-on-target, we combine muon neutrino charged current and neutral current data sets from the Near and Far Detectors and observe no evidence for deviations from standard three-flavor neutrino oscillations. The ratios of reconstructed energy spectra in the two detectors constrain the size of large extra dimensions to be smaller than $0.45\,\mu\text{m}$ at 90% C.L. in the limit of a vanishing lightest active neutrino mass. Stronger limits are obtained for non-vanishing masses., Comment: 7 pages, 5 figures

Published
2016
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85. Measurement of single $\pi^0$ production by coherent neutral-current $\nu$ Fe interactions in the MINOS Near Detector

Author

Adamson, P., Anghel, I., Aurisano, A., Barr, G., Bishai, M., Blake, A., Bock, G. J., Bogert, D., Cao, S. V., Carroll, T. J., Castromonte, C. M., Chen, R., Cherdack, D., Childress, S., Coelho, J. A. B., Corwin, L., Cronin-Hennessy, D., de Jong, J. K., De Rijck, S., Devan, A. V., Devenish, N. E., Diwan, M. V., Escobar, C. O., Evans, J. J., Falk, E., Feldman, G. J., Flanagan, W., Frohne, M. V., Gabrielyan, M., Gallagher, H. R., Germani, S., Gomes, R. A., Goodman, M. C., Gouffon, P., Graf, N., Gran, R., Grzelak, K., Habig, A., Hahn, S. R., Hartnell, J., Hatcher, R., Holin, A., Huang, J., Hylen, J., Irwin, G. M., Isvan, Z., James, C., Jensen, D., Kafka, T., Kasahara, S. M. S., Koizumi, G., Kordosky, M., Kreymer, A., Lang, K., Ling, J., Litchfield, P. J., Lucas, P., Mann, W. A., Marshak, M. L., Mayer, N., McGivern, C., Medeiros, M. M., Mehdiyev, R., Meier, J. R., Messier, M. D., Miller, W. H., Mishra, S. R., Sher, S. Moed, Moore, C. D., Mualem, L., Musser, J., Naples, D., Nelson, J. K., Newman, H. B., Nichol, R. J., Nowak, J. A., O'Connor, J., Oliver, W. P., Orchanian, M., Pahlka, R. B., Paley, J., Patterson, R. B., Pawloski, G., Perch, A., Pfutzner, M. M., Phan, D. D., Phan-Budd, S., Plunkett, R. K., Poonthottathil, N., Qiu, X., Radovic, A., Rebel, B., Rosenfeld, C., Rubin, H. A., Sail, P., Sanchez, M. C., Schneps, J., Schreckenberger, A., Schreiner, P., Sharma, R., Sousa, A., Tagg, N., Talaga, R. L., Thomas, J., Thomson, M. A., Tian, X., Timmons, A., Todd, J., Tognini, S. C., Toner, R., Torretta, D., Tzanakos, G., Urheim, J., Vahle, P., Viren, B., Weber, A., Webb, R. C., White, C., Whitehead, L., Whitehead, L. H., Wojcicki, S. G., and Zwaska, R.

Subjects
High Energy Physics - Experiment
Abstract

Forward single $\pi^0$ production by coherent neutral-current interactions, $\nu \mathcal{A} \to \nu \mathcal{A} \pi^0$, is investigated using a 2.8$\times 10^{20}$ protons-on-target exposure of the MINOS Near Detector. For single-shower topologies, the event distribution in production angle exhibits a clear excess above the estimated background at very forward angles for visible energy in the range~1-8 GeV. Cross sections are obtained for the detector medium comprised of 80% iron and 20% carbon nuclei with $\langle \mathcal{A} \rangle = 48$, the highest-$\langle \mathcal{A} \rangle$ target used to date in the study of this coherent reaction. The total cross section for coherent neutral-current single-$\pi^0$ production initiated by the $\nu_\mu$ flux of the NuMI low-energy beam with mean (mode) $E_{\nu}$ of 4.9 GeV (3.0 GeV), is $77.6\pm5.0\,(\text{stat}) ^{+15.0}_{-16.8}\,(\text{syst})\times10^{-40}\,\text{cm}^2~\text{per nucleus}$. The results are in good agreement with predictions of the Berger-Sehgal model., Comment: 19 pages, 14 figures Supplementary Materials, MINOS Collaboration

Published
2016
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86. Optical observation of spin-density-wave fluctuations in Ba122 iron-based superconductors

Author

Xu, B., Dai, Y. M., Xiao, H., Shen, B., Ye, Z. R., Forget, A., Colson, D., Feng, D. L., Wen, H. H., Qiu, X. G., and Lobo, R. P. S. M.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

In iron-based superconductors, a spin-density-wave (SDW) magnetic order is suppressed with doping and unconventional superconductivity appears in close proximity to the SDW instability. The optical response of the SDW order shows clear gap features: substantial suppression in the low-frequency optical conductivity, alongside a spectral weight transfer from low to high frequencies. Here, we study the detailed temperature dependence of the optical response in three different series of the Ba122 system [Ba$_{1-x}$K$_{x}$Fe$_{2}$As$_{2}$, Ba(Fe$_{1-x}$Co$_{x}$)$_{2}$As$_{2}$ and BaFe$_{2}$(As$_{1-x}$P$_{x}$)$_{2}$]. Intriguingly, we found that the suppression of the low-frequency optical conductivity and spectral weight transfer appear at a temperature $T^{\ast}$ much higher than the SDW transition temperature $T_{SDW}$. Since this behavior has the same optical feature and energy scale as the SDW order, we attribute it to SDW fluctuations. Furthermore, $T^{\ast}$ is suppressed with doping, closely following the doping dependence of the nematic fluctuations detected by other techniques. These results suggest that the magnetic and nematic orders have an intimate relationship, in favor of the magnetic-fluctuation-driven nematicity scenario in iron-based superconductors., Comment: 6 pages 5 figures

Published
2016
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87. Search for Sterile Neutrinos Mixing with Muon Neutrinos in MINOS

Author

Adamson, P., Anghel, I., Aurisano, A., Barr, G., Bishai, M., Blake, A., Bock, G. J., Bogert, D., Cao, S. V., Carroll, T. J., Castromonte, C. M., Chen, R., Childress, S., Coelho, J. A. B., Corwin, L., Cronin-Hennessy, D., de Jong, J. K., De Rijck, S., Devan, A. V., Devenish, N. E., Diwan, M. V., Escobar, C. O., Evans, J. J., Falk, E., Feldman, G. J., Flanagan, W., Frohne, M. V., Gabrielyan, M., Gallagher, H. R., Germani, S., Gomes, R. A., Goodman, M. C., Gouffon, P., Graf, N., Gran, R., Grzelak, K., Habig, A., Hahn, S. R., Hartnell, J., Hatcher, R., Holin, A., Huang, J., Hylen, J., Irwin, G. M., Isvan, Z., James, C., Jensen, D., Kafka, T., Kasahara, S. M. S., Koizumi, G., Kordosky, M., Kreymer, A., Lang, K., Ling, J., Litchfield, P. J., Lucas, P., Mann, W. A., Marshak, M. L., Mayer, N., McGivern, C., Medeiros, M. M., Mehdiyev, R., Meier, J. R., Messier, M. D., Miller, W. H., Mishra, S. R., Sher, S. Moed, Moore, C. D., Mualem, L., Musser, J., Naples, D., Nelson, J. K., Newman, H. B., Nichol, R. J., Nowak, J. A., O'Connor, J., Orchanian, M., Pahlka, R. B., Paley, J., Patterson, R. B., Pawloski, G., Perch, A., Pfutzner, M. M., Phan, D. D., Phan-Budd, S., Plunkett, R. K., Poonthottathil, N., Qiu, X., Radovic, A., Rebel, B., Rosenfeld, C., Rubin, H. A., Sail, P., Sanchez, M. C., Schneps, J., Schreckenberger, A., Schreiner, P., Sharma, R., Sousa, A., Tagg, N., Talaga, R. L., Thomas, J., Thomson, M. A., Tian, X., Timmons, A., Todd, J., Tognini, S. C., Toner, R., Torretta, D., Tzanakos, G., Urheim, J., Vahle, P., Viren, B., Weber, A., Webb, R. C., White, C., Whitehead, L., Whitehead, L. H., Wojcicki, S. G., and Zwaska, R.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We report results of a search for oscillations involving a light sterile neutrino over distances of 1.04 and $735\,\mathrm{km}$ in a $\nu_{\mu}$-dominated beam with a peak energy of $3\,\mathrm{GeV}$. The data, from an exposure of $10.56\times 10^{20}\,\textrm{protons on target}$, are analyzed using a phenomenological model with one sterile neutrino. We constrain the mixing parameters $\theta_{24}$ and $\Delta m^{2}_{41}$ and set limits on parameters of the four-dimensional Pontecorvo-Maki-Nakagawa-Sakata matrix, $|U_{\mu 4}|^{2}$ and $|U_{\tau 4}|^{2}$, under the assumption that mixing between $\nu_{e}$ and $\nu_{s}$ is negligible ($|U_{e4}|^{2}=0$). No evidence for $\nu_{\mu} \to \nu_{s}$ transitions is found and we set a world-leading limit on $\theta_{24}$ for values of $\Delta m^{2}_{41} \lesssim 1\,\mathrm{eV}^{2}$., Comment: 7 pages, 4 figures

Published
2016
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88. Limits on Active to Sterile Neutrino Oscillations from Disappearance Searches in the MINOS, Daya Bay, and Bugey-3 Experiments

Author

Bay, Daya, Collaborations, MINOS, Adamson, P., An, F. P., Anghel, I., Aurisano, A., Balantekin, A. B., Band, H. R., Barr, G., Bishai, M., Blake, A., Bock, S. Blyth G. J., Bogert, D., Cao, D., Cao, G. F., Cao, J., Cao, S. V., Carroll, T. J., Castromonte, C. M., Cen, W. R., Chan, Y. L., Chang, J. F., Chang, L. C., Chang, Y., Chen, H. S., Chen, Q. Y., Chen, R., Chen, S. M., Chen, Y., Chen, Y. X., Cheng, J., Cheng, J. -H., Chen, Y. P., Cheng, Z. K., Cherwinka, J. J., Childress, S., Chu, M. C., Chukanov, A., Coelho, J. A. B., Corwin, L., Cronin-Hennessy, D., Cummings, J. P., de Arcos, J., De Rijck, S., Deng, Z. Y., Devan, A. V., Devenish, N. E., Ding, X. F., Ding, Y. Y., Diwan, M. V., Dolgareva, M., Dove, J., Dwyer, D. A., Edwards, W. R., Escobar, C. O., Evans, J. J., Falk, E., Feldman, G. J., Flanagan, W., Frohne, M. V., Gabrielyan, M., Gallagher, H. R., Germani, S., Gill, R., Gomes, R. A., Gonchar, M., Gong, G. H., Gong, H., Goodman, M. C., Gouffon, P., Graf, N., Gran, R., Grassi, M., Grzelak, K., Gu, W. Q., Guan, M. Y., Guo, L., Guo, R. P., Guo, X. H., Guo, Z., Habig, A., Hackenburg, R. W., Hahn, S. R., Han, R., Hans, S., Hartnell, J., Hatcher, R., He, M., Heeger, K. M., Heng, Y. K., Higuera, A., Holin, A., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, T., Hu, W., Huang, E. C., Huang, H. X., Huang, J., Huang, X. T., Huber, P., Huo, W., Hussain, G., Hylen, J., Irwin, G. M., Isvan, Z., Jaffe, D. E., Jaffke, P., James, C., Jen, K. L., Jensen, D., Jetter, S., Ji, X. L., Ji, X. P., Jiao, J. B., Johnson, R. A., de Jong, J. K., Joshi, J., Kafka, T., Kang, L., Kasahara, S. M. S., Kettell, S. H., Kohn, S., Koizumi, G., Kordosky, M., Kramer, M., Kreymer, A., Kwan, 1 K. K., Kwok, M. W., Kwok, T., Lang, K., Langford, T. J., Lau, K., Lebanowski, L., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, C., Li, D. J., Li, F., Li, G. S., Li, Q. J., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Lin, S. K., Lin, Y. -C., Link, J. J. Ling J. M., Litchfield, P. J., Littenberg, L., Littlejohn, B. R., Liu, D. W., Liu, J. C., Liu, J. L., Loh, C. W., Lu, C., Lu, H. Q., Lu, J. S., Lucas, P., Luk, K. B., Lv, Z., Ma, Q. M., Ma, X. B., Ma, X. Y., Ma, Y. Q., Malyshkin, Y., Mann, W. A., Marshak, M. L., Caicedo, D. A. Martinez, Mayer, N., McDonald, K. T., McGivern, C., McKeown, R. D., Medeiros, M. M., Mehdiyev, R., Meier, J. R., Messier, M. D., Miller, W. H., Mishra, S. R., Mitchell, I., Mooney, M., Moore, C. D., Mualem, L., Musser, J., Nakajima, Y., Naples, D., Napolitano, J., Naumov, D., Naumova, E., Nelson, J. K., Newman, H. B., Ngai, H. Y., Nichol, R. J., Ning, Z., Nowak, A., O'Connor, J., Ochoa-Ricoux, J. P., Olshevskiy, A., Orchanian, M., Pahlka, R. B., Paley, J., Pan, H. -R., Park, J., Patterson, R. B., Patton, S., Pawloski, G., Pec, V., Peng, J. C., Perch, A., Pfutzner, M. M., Phan, D. D., Phan-Budd, S., Pinsky, L., Plunkett, R. K., Poonthottathil, N., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Qiu, X., Radovic, A., Raper, N., Rebel, B., Ren, J., Rosenfeld, C., Rosero, R., Roskovec, B., Ruan, X. C., Rubin, H. A., Sail, P., Sanchez, M. C., Schneps, J., Schreckenberger, A., Schreiner, P., Sharma, R., Sher, S. Moed, Sousa, A., Steiner, H., Sun, G. X., Sun, J. L., Tagg, N., Talaga, R. L., Tang, W., Taychenachev, D., Thomas, J., Thomson, M. A., Timmons, X. Tian A., Todd, J., Tognini, S. C., Toner, R., Torretta, D., Treskov, K., Tsang, K. V., Tull, C. E., Tzanakos, G., Urheim, J., Vahle, P., Viaux, N., Viren, B., Vorobel, V., Wang, C. H., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Webb, R. C., Weber, A., Wei, H. Y., Wen, L. J., Whisnant, K., White, C., Whitehead, L. Whitehead L. H., Wise, T., Wojcicki, S. G., Wong, H. L. H., Wong, S. C. F., Worcester, E., Wu, C. -H., Wu, Q., Wu, W. J., Xia, D. M., Xia, J. K., Xing, Z. Z., Xu, J. L., Xu, J. Y., Xu, Y., Xue, T., Yang, C. G., Yang, H., Yang, L., Yang, M. S., Yang, M. T., Ye., M., Ye, Z., Yeh, M., Young, B. L., Yu, Z. Y., Zeng, S., Zhang, L. ZhanC., Zhang, H. H., Zhang, J. W., Zhang, Q. M., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, Q. W., Zhao, Y. B., Zhong, W. L., Zhou, L., Zhou, N., Zhuang, H. L., and Zou, J. H.

Subjects
High Energy Physics - Experiment
Abstract

Searches for a light sterile neutrino have been performed independently by the MINOS and the Daya Bay experiments using the muon (anti)neutrino and electron antineutrino disappearance channels, respectively. In this Letter, results from both experiments are combined with those from the Bugey-3 reactor neutrino experiment to constrain oscillations into light sterile neutrinos. The three experiments are sensitive to complementary regions of parameter space, enabling the combined analysis to probe regions allowed by the LSND and MiniBooNE experiments in a minimally extended four-neutrino flavor framework. Stringent limits on $\sin^2 2\theta_{\mu e}$ are set over 6 orders of magnitude in the sterile mass-squared splitting $\Delta m^2_{41}$. The sterile-neutrino mixing phase space allowed by the LSND and MiniBooNE experiments is excluded for $\Delta m^2_{41} < 0.8$ eV$^2$ at 95% CL$_s$., Comment: 8 pages, 4 figures, published in Physical Review Letters. Data release found at http://www-numi.fnal.gov/PublicInfo/forscientists.html and at https://wiki.bnl.gov/dayabay/index.php?title=Daya_Bay%27s_Sterile_Neutrino_Results_in_2016

Published
2016
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89. Spectroscopy of the neutron-rich hypernucleus $^{7}_{\Lambda}$He from electron scattering

Author

Gogami, T., Chen, C., Kawama, D., Achenbach, P., Ahmidouch, A., Albayrak, I., Androic, D., Asaturyan, A., Asaturyan, R., Ates, O., Baturin, P., Badui, R., Boeglin, W., Bono, J., Brash, E., Carter, P., Chiba, A., Christy, E., Danagoulian, S., De Leo, R., Doi, D., Elaasar, M., Ent, R., Fujii, Y., Fujita, M., Furic, M., Gabrielyan, M., Gan, L., Garibaldi, F., Gaskell, D., Gasparian, A., Han, Y., Hashimoto, O., Horn, T., Hu, B., Hungerford, Ed. V., Jones, M., Kanda, H., Kaneta, M., Kato, S., Kawai, M., Khanal, H., Kohl, M., Liyanage, A., Luo, W., Maeda, K., Margaryan, A., Markowitz, P., Maruta, T., Matsumura, A., Maxwell, V., Mkrtchyan, A., Mkrtchyan, H., Nagao, S., Nakamura, S. N., Narayan, A., Neville, C., Niculescu, G., Niculescu, M. I., Nunez, A., Nuruzzaman, Okayasu, Y., Petkovic, T., Pochodzalla, J., Qiu, X., Reinhold, J., Rodriguez, V. M., Samanta, C., Sawatzky, B., Seva, T., Shichijo, A., Tadevosyan, V., Tang, L., Taniya, N., Tsukada, K., Veilleux, M., Vulcan, W., Wesselmann, F. R., Wood, S. A., Yamamoto, T., Ya, L., Ye, Z., Yokota, K., Yuan, L., Zhamkochyan, S., and Zhu, L.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The missing mass spectroscopy of the $^{7}_{\Lambda}$He hypernucleus was performed, using the $^{7}$Li$(e,e^{\prime}K^{+})^{7}_{\Lambda}$He reaction at the Thomas Jefferson National Accelerator Facility Hall C. The $\Lambda$ binding energy of the ground state (1/2$^{+}$) was determined with a smaller error than that of the previous measurement, being $B_{\Lambda}$ = 5.55 $\pm$ 0.10(stat.) $\pm$ 0.11(sys.) MeV. The experiment also provided new insight into charge symmetry breaking in p-shell hypernuclear systems. Finally, a peak at $B_{\Lambda}$ = 3.65 $\pm$ 0.20(stat.) $\pm$ 0.11(sys.) MeV was observed and assigned as a mixture of 3/2$^{+}$ and 5/2$^{+}$ states, confirming the "gluelike" behavior of $\Lambda$, which makes an unstable state in $^{6}$He stable against neutron emission., Comment: 6 pages, 4 figures

Published
2016
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90. A search for flavor-changing non-standard neutrino interactions using $\nu_{e}$ appearance in MINOS

Author

Adamson, P., Anghel, I., Aurisano, A., Barr, G., Bishai, M., Blake, A., Bock, G. J., Bogert, D., Cao, S. V., Carroll, T. J., Castromonte, C. M., Chen, R., Childress, S., Coelho, J. A. B., Corwin, L., Cronin-Hennessy, D., de Jong, J. K., de Rijck, S., Devan, A. V., Devenish, N. E., Diwan, M. V., Escobar, C. O., Evans, J. J., Falk, E., Feldman, G. J., Flanagan, W., Frohne, M. V., Gabrielyan, M., Gallagher, H. R., Germani, S., Gomes, R. A., Goodman, M. C., Gouffon, P., Graf, N., Gran, R., Grzelak, K., Habig, A., Hahn, S. R., Hartnell, J., Hatcher, R., Holin, A., Huang, J., Hylen, J., Irwin, G. M., Isvan, Z., James, C., Jensen, D., Kafka, T., Kasahara, S. M. S., Koizumi, G., Kordosky, M., Kreymer, A., Lang, K., Ling, J., Litchfield, P. J., Lucas, P., Mann, W. A., Marshak, M. L., Mayer, N., McGivern, C., Medeiros, M. M., Mehdiyev, R., Meier, J. R., Messier, M. D., Miller, W. H., Mishra, S. R., Sher, S. Moed, Moore, C. D., Mualem, L., Musser, J., Naples, D., Nelson, J. K., Newman, H. B., Nichol, R. J., Nowak, J. A., O'Connor, J., Orchanian, M., Pahlka, R. B., Paley, J., Patterson, R. B., Pawloski, G., Perch, A., Pfützner, M. M., Phan, D. D., Phan-Budd, S., Plunkett, R. K., Poonthottathil, N., Qiu, X., Radovic, A., Rebel, B., Rosenfeld, C., Rubin, H. A., Sail, P., Sanchez, M. C., Schneps, J., Schreckenberger, A., Schreiner, P., Sharma, R., Sousa, A., Tagg, N., Talaga, R. L., Thomas, J., Thomson, M. A., Tian, X., Timmons, A., Todd, J., Tognini, S. C., Toner, R., Torretta, D., Tzanakos, G., Urheim, J., Vahle, P., Viren, B., Weber, A., Webb, R. C., White, C., Whitehead, L., Whitehead, L. H., Wojcicki, S. G., and Zwaska, R.

Subjects
High Energy Physics - Experiment
Abstract

We report new constraints on flavor-changing non-standard neutrino interactions from the MINOS long-baseline experiment using $\nu_{e}$ and $\bar{\nu}_{e}$ appearance candidate events from predominantly $\nu_{\mu}$ and $\bar{\nu}_{\mu}$ beams. We used a statistical selection algorithm to separate $\nu_{e}$ candidates from background events, enabling an analysis of the combined MINOS neutrino and antineutrino data. We observe no deviations from standard neutrino mixing, and thus place constraints on the non-standard interaction matter effect, $|\varepsilon_{e\tau}|$, and phase, $(\delta_{CP}+\delta_{e\tau})$, using a thirty-bin likelihood fit., Comment: 5 pages, 3 figures v2: References added, caption and probability calculation clarified. Result unchanged

Published
2016
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91. Search for time-independent Lorentz violation using muon neutrino to muon antineutrino transitions in MINOS

Author

Adamson, P., Anghel, I., Aurisano, A., Barr, G., Bishai, M., Blake, A., Bock, G. J., Bogert, D., Cao, S. V., Carroll, T. J., Castromonte, C. M., Chen, R., Childress, S., Coelho, J. A. B., Corwin, L., Cronin-Hennessy, D., de Jong, J. K., de Rijck, S., Devan, A. V., Devenish, N. E., Diwan, M. V., Escobar, C. O., Evans, J. J., Falk, E., Feldman, G. J., Flanagan, W., Frohne, M. V., Gabrielyan, M., Gallagher, H. R., Germani, S., Gomes, R. A., Goodman, M. C., Gouffon, P., Graf, N., Gran, R., Grzelak, K., Habig, A., Hahn, S. R., Hartnell, J., Hatcher, R., Holin, A., Huang, J., Hylen, J., Irwin, G. M., Isvan, Z., James, C., Jensen, D., Kafka, T., Kasahara, S. M. S., Koizumi, G., Kordosky, M., Kreymer, A., Lang, K., Ling, J., Litchfield, P. J., Lucas, P., Mann, W. A., Marshak, M. L., Mayer, N., McGivern, C., Medeiros, M. M., Mehdiyev, R., Meier, J. R., Messier, M. D., Miller, W. H., Mishra, S. R., Sher, S. Moed, Moore, C. D., Mualem, L., Musser, J., Naples, D., Nelson, J. K., Newman, H. B., Nichol, R. J., Nowak, J. A., O'Connor, J., Orchanian, M., Pahlka, R. B., Paley, J., Patterson, R. B., Pawloski, G., Perch, A., Pfützner, M. M., Phan, D. D., Phan-Budd, S., Plunkett, R. K., Poonthottathil, N., Qiu, X., Radovic, A., Rebel, B., Rosenfeld, C., Rubin, H. A., Sail, P., Sanchez, M. C., Schneps, J., Schreckenberger, A., Schreiner, P., Sharma, R., Sousa, A., Tagg, N., Talaga, R. L., Thomas, J., Thomson, M. A., Tian, X., Timmons, A., Todd, J., Tognini, S. C., Toner, R., Torretta, D., Tzanakos, G., Urheim, J., Vahle, P., Viren, B., Weber, A., Webb, R. C., White, C., Whitehead, L., Whitehead, L. H., Wojcicki, S. G., and Zwaska, R.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

Data from the MINOS experiment has been used to search for mixing between muon neutrinos and muon antineutrinos using a time-independent Lorentz-violating formalism derived from the Standard-Model Extension (SME). MINOS is uniquely capable of searching for muon neutrino-antineutrino mixing given its long baseline and ability to distinguish between neutrinos and antineutrinos on an event-by-event basis. Neutrino and antineutrino interactions were observed in the MINOS Near and Far Detectors from an exposure of 10.56$\times10^{20}$ protons-on-target from the NuMI neutrino-optimized beam. No evidence was found for such transitions and new, highly stringent limits were placed on the SME coefficients governing them. We place the first limits on the SME parameters $(c_{L})^{TT}_{\mu\mu} $ and $(c_{L})^{TT}_{\tau\tau}$ at $-8.4\times10^{-23} < (c_{L})^{TT}_{\mu\mu} < 8.0\times10^{-23}$ and $-8.0\times10^{-23} < (c_{L})^{TT}_{\tau\tau} < 8.4\times10^{-23}$, and the world's best limits on the $\tilde{g}^{ZT}_{\mu\overline{\mu}}$ and $\tilde{g}^{ZT}_{\tau\overline{\tau}}$ parameters at $|\tilde{g}^{ZT}_{\mu\overline{\mu}}| < 3.3\times 10^{-23}$ and $|\tilde{g}^{ZT}_{\tau\overline{\tau}}| < 3.3\times 10^{-23}$, all limits quoted at $3\sigma$., Comment: This paper has been withdrawn by the author due to a mistake in the calculations

Published
2016

93. The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique

Author

Wang H, Zhou C, Su Y, Gou K, Geng X, and Qiu X

Subjects
itraconazole, voriconazole, ripretinib, uplc-ms/ms, pharmacokinetics, beagle dog, Therapeutics. Pharmacology, RM1-950
Abstract

Hui-jun Wang,1 Chun-yan Zhou,1 Yan-ding Su,1 Kai-feng Gou,1 Xiao-nan Geng,1 Xiang-jun Qiu1,2 1Department of Pharmacy, School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, 471023, People’s Republic of China; 2Functional Experiment Teaching Center, School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, 471023, People’s Republic of ChinaCorrespondence: Xiang-jun QiuFunctional Experiment Teaching Center, School of Basic Medical Sciences, Henan University of Science and Technology, 263 Kaiyuan Avenue, Luoyang, 471023, People’s Republic of ChinaTel +8613698882699Fax +86379-64830346Email lyxiangjun@126.comBackground: A new UPLC-MS/MS technique for the determination of ripretinib in beagle dog plasma was developed, and the pharmacokinetic effects of voriconazole and itraconazole on ripretinib in beagle dogs were studied.Methods: After extraction with ethyl acetate under alkaline conditions, ripretinib was detected using avapritinib as the internal standard (IS). The mobile phases were 0.1% formic acid-acetonitrile. The scanning method was multi-reaction monitoring using ESI+ source, and the ion pairs for ripretinib and IS were m/z 509.93→ 416.85 and 499.1→ 482.09, respectively. This animal experiment adopted a three period self-control experimental design. In the first period, ripretinib was orally administered to six beagle dogs at a dose of 5 mg/kg. In the second period, the same six beagle dogs were orally given itraconazole at a dose of 7 mg/kg, after 30 min, ripretinib was orally given. In the third period, voriconazole at a dose of 7 mg/kg was given orally, and then ripretinib was orally given. At different time points, the blood samples were collected. The concentration of ripretinib was detected, and the pharmacokinetic parameters of ripretinib were calculated.Results: Ripretinib had a good linear relationship in the range of 1– 1000 ng/mL. The precision, accuracy, recovery, matrix effect and stability met the requirements of the guiding principles. After erdafitinib combined with itraconazole, the Cmax and AUC0→t of ripretinib increased by 38.35% and 36.36%, respectively, and the t1/2 was prolonged to 7.53 h. After ripretinib combined with voriconazole, the Cmax and AUC0→t of ripretinib increased by 37.44% and 25.52%, respectively, and the t1/2 was prolonged to 7.33 h.Conclusion: A new and reliable UPLC-MS/MS technique was fully optimized and developed to detect the concentration of ripretinib in beagle dog plasma. Itraconazole and voriconazole could inhibit the metabolism of ripretinib in beagle dogs and increase the plasma exposure of ripretinib.Keywords: itraconazole, voriconazole, ripretinib, UPLC-MS/MS, pharmacokinetics, beagle dog

Published
2021

94. Roles of Oxidative Stress and Raftlin in Wound Healing Under Negative-Pressure Wound Therapy

Author

Qiu X, Wu Y, Zhang D, Zhang H, Yu A, and Li Z

Subjects
sod, cat, mda, raftlin, negative-pressure wound therapy, Dermatology, RL1-803
Abstract

Xingan Qiu,&ast; Yifan Wu,&ast; Dong Zhang, Hao Zhang, Aixi Yu, Zonghuan Li Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Aixi Yu; Zonghuan LiDepartment of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, People’s Republic of ChinaTel +86-27-67813120; +86-134 76041532Email yuaixi@whu.edu.cn; lizonghuan@whu.edu.cnBackground: Negative-pressure wound therapy (NPWT) is an effective way to promote wound healing. However, its mechanisms have not been investigated thoroughly. Growing evidence suggests that oxidative stress and Raftlin levels play important roles in wound healing. However, whether NPWT promotes wound healing through this mechanism remains unclear.Purpose: Our study focuses on the different levels of oxidative stress and antioxidant response between wounds treated by NPWT and routine dressing change. The objective of this study was to measure the differences in Raftlin levels between the two groups, which is a new biomarker related to wound healing.Methods: We divided 48 male Sprague-Dawley rats with identical full-thickness skin defects into two groups. At specific times (0, 3, 5, 7, 9, 11, and 13 days after surgery), wound tissue samples were obtained for immunohistochemistry and biochemical analysis. The expression of Raftlin and levels of oxidative stress, including malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels were measured by biochemical analysis. Wound-healing times were also compared.Results: In the NPWT group, MDA levels were significantly decreased on days 3, 5, and 7. Furthermore, the expressions of SOD and CAT were significantly reduced on days 3 and 5. Our data also revealed that Raftlin was significantly upregulated across the whole period of wound healing. Moreover, wound healing in the NPWT group was significantly more rapid (16 days on average) than in the control group (24 days on average). On day 13 post surgery, the wound-healing percentage in the NPWT group was 91%, while that in the control group was 48%.Conclusion: NPWT may promote wound healing by upregulating Raftlin and inhibiting oxidative stress levels.Keywords: SOD, CAT, MDA, Raftlin, negative-pressure wound therapy

Published
2021

95. Evaluation of Ferroptosis-related Gene AKR1C1 as a Novel Biomarker Associated with the Immune Microenvironment and Prognosis in Breast Cancer

Author

Zhang Z, Qiu X, Yan Y, Liang Q, Cai Y, Peng B, Xu Z, and Xia F

Subjects
breast cancer, akr1c1, ferroptosis, immune microenvironment, immune infiltration, Medicine (General), R5-920
Abstract

Zeyu Zhang,1 Xiangyuan Qiu,1 Yuanliang Yan,2 Qiujiu Liang,2 Yuan Cai,3 Bi Peng,3 Zhijie Xu,3,4 Fada Xia1 1Department of Thyroid Surgery, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 3Department of Pathology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 4National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaCorrespondence: Zhijie XuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaEmail xzj1322007@csu.edu.cnFada XiaDepartment of Thyroid Surgery, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaEmail xiafada@csu.edu.cnBackground: Ferroptosis is the latest-discovered, iron-dependent form of regulated cell death. It has been increasingly recognized that ferroptosis-related genes participate in oncogenesis and development of cancers, including breast cancer (BRCA). Thus, It is important to explore the biofunctions of ferroptosis-related genes in BRCA.Methods: Transcriptome microarray datasets (GSE22358, GSE9014 and GSE8977, GSE2990 and GSE2034) and TCGA-BRCA were retrieved for analyses. And a variety of computational tools were used to identify the roles and associated biological functions in BRCA.Results: Two ferroptosis-related genes (AKR1C1 and AKR1C3) were significantly expressed in GSE22358, GSE9014 and GSE8977. Higher expression of AKR1C1 was related with favorable prognosis. TCGA-BRCA further confirmed the expression of AKR1C1 and the prognostic value of AKR1C1. Co-expression analyses showed the most enriched GO term and KEGG pathways were termination of DNA-templated transcription and Fanconi anemia pathway. Subsequently, immunological analyses showed AKR1C1 was significantly associated with various immune infiltration cells; among these, dendritic cells, neutrophils, macrophages were the top three infiltrating cells. Furthermore, AKR1C1 was also associated with multiple immunostimulatory molecules and chemokines, including PD-1, PD-L1, CTLA4, B7-H3, VSIR, IL-6, BTLA, CXCL2, and CCR7. These results indicated the potential roles of AKR1C1 in the immune reaction during the pathogenesis of breast cancer.Conclusion: This study firstly demonstrated that ferroptosis-related gene, AKR1C1, could be associated with immune microenvironment, thereby influencing the development and prognosis of patient with breast cancer.Keywords: breast cancer, AKR1C1, ferroptosis, immune microenvironment, immune infiltration

Published
2021

98. Measurement of the Multiple-Muon Charge Ratio in the MINOS Far Detector

Author

Minos Collaboration, Adamson, P., Anghel, I., Aurisano, A., Barr, G., Bishai, M., Blake, A., Bock, G. J., Bogert, D., Cao, S. V., Carroll, T. J., Castromonte, C. M., Chen, R., Childress, S., Coelho, J. A. B., Corwin, L., Cronin-Hennessy, D., de Jong, J. K., De Rijck, S., Devan, A. V., Devenish, N. E., Diwan, M. V., Escobar, C. O., Evans, J. J., Falk, E., Feldman, G. J., Flanagan, W., Frohne, M. V., Gabrielyan, M., Gallagher, H. R., Germani, S., Gomes, R. A., Goodman, M. C., Gouffon, P., Graf, N., Gran, R., Grzelak, K., Habig, A., Hahn, S. R., Hartnell, J., Hatcher, R., Holin, A., Huang, J., Hylen, J., Irwin, G. M., Isvan, Z., James, C., Jensen, D., Kafka, T., Kasahara, S. M. S., Koizumi, G., Kordosky, M., Kreymer, A., Lang, K., Ling, J., Litchfield, P. J., Lucas, P., Mann, W. A., Marshak, M. L., Mayer, N., McGivern, C., Medeiros, M. M., Mehdiyev, R., Meier, J. R., Messier, M. D., Miller, W. H., Mishra, S. R., Sher, S. Moed, Moore, C. D., Mualem, L., Musser, J., Naples, D., Nelson, J. K., Newman, H. B., Nichol, R. J., Nowak, J. A., O'Connor, J., Orchanian, M., Pahlka, R. B., Paley, J., Patterson, R. B., Pawloski, G., Perch, A., Pfützner, M., Phan, D. D., Phan-Budd, S., Plunkett, R. K., Poonthottathil, N., Qiu, X., Radovic, A., Rebel, B., Rosenfeld, C., Rubin, H. A., Sail, P., Sanchez, M. C., Schneps, J., Schreckenberger, A., Schreiner, P., Sharma, R., Sousa, A., Tagg, N., Talaga, R. L., Thomas, J., Thomson, M. A., Tian, X., Timmons, A., Todd, J., Tognini, S. C., Toner, R., Torretta, D., Tzanakos, G., Urheim, J., Vahle, P., Viren, B., Weber, A., Webb, R. C., White, C., Whitehead, L., Whitehead, L. H., Wojcicki, S. G., and Zwaska, R.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The charge ratio, $R_\mu = N_{\mu^+}/N_{\mu^-}$, for cosmogenic multiple-muon events observed at an under- ground depth of 2070 mwe has been measured using the magnetized MINOS Far Detector. The multiple-muon events, recorded nearly continuously from August 2003 until April 2012, comprise two independent data sets imaged with opposite magnetic field polarities, the comparison of which allows the systematic uncertainties of the measurement to be minimized. The multiple-muon charge ratio is determined to be $R_\mu = 1.104 \pm 0.006 {\rm \,(stat.)} ^{+0.009}_{-0.010} {\rm \,(syst.)} $. This measurement complements previous determinations of single-muon and multiple-muon charge ratios at underground sites and serves to constrain models of cosmic ray interactions at TeV energies., Comment: 10 pages, 2 figures

Published
2016
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99. First measurement of muon-neutrino disappearance in NOvA

Author

Adamson, P., Ader, C., Andrews, M., Anfimov, N., Anghel, I., Arms, K., Arrieta-Diaz, E., Aurisano, A., Ayres, D., Backhouse, C., Baird, M., Bambah, B. A., Bays, K., Bernstein, R., Betancourt, M., Bhatnagar, V., Bhuyan, B., Bian, J., Biery, K., Blackburn, T., Bocean, V., Bogert, D., Bolshakova, A., Bowden, M., Bower, C., Broemmelsiek, D., Bromberg, C., Brunetti, G., Bu, X., Butkevich, A., Capista, D., Catano-Mur, E., Chase, T. R., Childress, S., Choudhary, B. C., Chowdhury, B., Coan, T. E., Coelho, J. A. B., Colo, M., Cooper, J., Corwin, L., Cronin-Hennessy, D., Cunningham, A., Davies, G. S., Davies, J. P., Del Tutto, M., Derwent, P. F., Deepthi, K. N., Demuth, D., Desai, S., Deuerling, G., Devan, A., Dey, J., Dharmapalan, R., Ding, P., Dixon, S., Djurcic, Z., Dukes, E. C., Duyang, H., Ehrlich, R., Feldman, G. J., Felt, N., Fenyves, E. J., Flumerfelt, E., Foulkes, S., Frank, M. J., Freeman, W., Gabrielyan, M., Gallagher, H. R., Gebhard, M., Ghosh, T., Gilbert, W., Giri, A., Goadhouse, S., Gomes, R. A., Goodenough, L., Goodman, M. C., Grichine, V., Grossman, N., Group, R., Grudzinski, J., Guarino, V., Guo, B., Habig, A., Handler, T., Hartnell, J., Hatcher, R., Hatzikoutelis, A., Heller, K., Howcroft, C., Huang, J., Huang, X., Hylen, J., Ishitsuka, M., Jediny, F., Jensen, C., Jensen, D., Johnson, C., Jostlein, H., Kafka, G. K., Kamyshkov, Y., Kasahara, S. M. S., Kasetti, S., Kephart, K., Koizumi, G., Kotelnikov, S., Kourbanis, I., Krahn, Z., Kravtsov, V., Kreymer, A., Kulenberg, Ch., Kumar, A., Kutnink, T., Kwarciancy, R., Kwong, J., Lang, K., Lee, A., Lee, W. M., Lee, K., Lein, S., Liu, J., Lokajicek, M., Lozier, J., Lu, Q., Lucas, P., Luchuk, S., Lukens, P., Lukhanin, G., Magill, S., Maan, K., Mann, W. A., Marshak, M. L., Martens, M., Martincik, J., Mason, P., Matera, K., Mathis, M., Matveev, V., Mayer, N., McCluskey, E., Mehdiyev, R., Merritt, H., Messier, M. D., Meyer, H., Miao, T., Michael, D., Mikheyev, S. P., Miller, W. H., Mishra, S. R., Mohanta, R., Moren, A., Mualem, L., Muether, M., Mufson, S., Musser, J., Newman, H. B., Nelson, J. K., Niner, E., Norman, A., Nowak, J., Oksuzian, Y., Olshevskiy, A., Oliver, J., Olson, T., Paley, J., Pandey, P., Para, A., Patterson, R. B., Pawloski, G., Pearson, N., Perevalov, D., Pershey, D., Peterson, E., Petti, R., Phan-Budd, S., Piccoli, L., Pla-Dalmau, A., Plunkett, R. K., Poling, R., Potukuchi, B., Psihas, F., Pushka, D., Qiu, X., Raddatz, N., Radovic, A., Rameika, R. A., Ray, R., Rebel, B., Rechenmacher, R., Reed, B., Reilly, R., Rocco, D., Rodkin, D., Ruddick, K., Rusack, R., Ryabov, V., Sachdev, K., Sahijpal, S., Sahoo, H., Samoylov, O., Sanchez, M. C., Saoulidou, N., Schlabach, P., Schneps, J., Schroeter, R., Sepulveda-Quiroz, J., Shanahan, P., Sherwood, B., Sheshukov, A., Singh, J., Singh, V., Smith, A., Smith, D., Smolik, J., Solomey, N., Sotnikov, A., Sousa, A., Soustruznik, K., Stenkin, Y., Strait, M., Suter, L., Talaga, R. L., Tamsett, M. C., Tariq, S., Tas, P., Tesarek, R. J., Thayyullathil, R. B., Thomsen, K., Tian, X., Tognini, S. C., Toner, R., Trevor, J., Tzanakos, G., Urheim, J., Vahle, P., Valerio, L., Vinton, L., Vrba, T., Waldron, A. V., Wang, B., Wang, Z., Weber, A., Wehmann, A., Whittington, D., Wilcer, N., Wildberger, R., Wildman, D., Williams, K., Wojcicki, S. G., Wood, K., Xiao, M., Xin, T., Yadav, N., Yang, S., Zadorozhnyy, S., Zalesak, J., Zamorano, B., Zhao, A., Zirnstein, J., and Zwaska, R.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

This paper reports the first measurement using the NOvA detectors of $\nu_\mu$ disappearance in a $\nu_\mu$ beam. The analysis uses a 14 kton-equivalent exposure of $2.74 \times 10^{20}$ protons-on-target from the Fermilab NuMI beam. Assuming the normal neutrino mass hierarchy, we measure $\Delta m^{2}_{32}=(2.52^{+0.20}_{-0.18})\times 10^{-3}$ eV$^{2}$ and $\sin^2\theta_{23}$ in the range 0.38-0.65, both at the 68% confidence level, with two statistically-degenerate best fit points at $\sin^2\theta_{23} = $ 0.43 and 0.60. Results for the inverted mass hierarchy are also presented., Comment: 8 pages, 6 figures. Submitted to Phys. Rev. D Rapid Communications

Published
2016
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100. First measurement of electron neutrino appearance in NOvA

Author

Adamson, P., Ader, C., Andrews, M., Anfimov, N., Anghel, I., Arms, K., Arrieta-Diaz, E., Aurisano, A., Ayres, D. S., Backhouse, C., Baird, M., Bambah, B. A., Bays, K., Bernstein, R., Betancourt, M., Bhatnagar, V., Bhuyan, B., Bian, J., Biery, K., Blackburn, T., Bocean, V., Bogert, D., Bolshakova, A., Bowden, M., Bower, C., Broemmelsiek, D., Bromberg, C., Brunetti, G., Bu, X., Butkevich, A., Capista, D., Catano-Mur, E., Chase, T. R., Childress, S., Choudhary, B. C., Chowdhury, B., Coan, T. E., Coelho, J. A. B., Colo, M., Cooper, J., Corwin, L., Cronin-Hennessy, D., Cunningham, A., Davies, G. S., Davies, J. P., Del Tutto, M., Derwent, P. F., Deepthi, K. N., Demuth, D., Desai, S., Deuerling, G., Devan, A., Dey, J., Dharmapalan, R., Ding, P., Dixon, S., Djurcic, Z., Dukes, E. C., Duyang, H., Ehrlich, R., Feldman, G. J., Felt, N., Fenyves, E. J., Flumerfelt, E., Foulkes, S., Frank, M. J., Freeman, W., Gabrielyan, M., Gallagher, H. R., Gebhard, M., Ghosh, T., Gilbert, W., Giri, A., Goadhouse, S., Gomes, R. A., Goodenough, L., Goodman, M. C., Grichine, V., Grossman, N., Group, R., Grudzinski, J., Guarino, V., Guo, B., Habig, A., Handler, T., Hartnell, J., Hatcher, R., Hatzikoutelis, A., Heller, K., Howcroft, C., Huang, J., Huang, X., Hylen, J., Ishitsuka, M., Jediny, F., Jensen, C., Jensen, D., Johnson, C., Jostlein, H., Kafka, G. K., Kamyshkov, Y., Kasahara, S. M. S., Kasetti, S., Kephart, K., Koizumi, G., Kotelnikov, S., Kourbanis, I., Krahn, Z., Kravtsov, V., Kreymer, A., Kulenberg, Ch., Kumar, A., Kutnink, T., Kwarciancy, R., Kwong, J., Lang, K., Lee, A., Lee, W. M., Lee, K., Lein, S., Liu, J., Lokajicek, M., Lozier, J., Lu, Q., Lucas, P., Luchuk, S., Lukens, P., Lukhanin, G., Magill, S., Maan, K., Mann, W. A., Marshak, M. L., Martens, M., Martincik, J., Mason, P., Matera, K., Mathis, M., Matveev, V., Mayer, N., McCluskey, E., Mehdiyev, R., Merritt, H., Messier, M. D., Meyer, H., Miao, T., Michael, D., Mikheyev, S. P., Miller, W. H., Mishra, S. R., Mohanta, R., Moren, A., Mualem, L., Muether, M., Mufson, S., Musser, J., Newman, H. B., Nelson, J. K., Niner, E., Norman, A., Nowak, J., Oksuzian, Y., Olshevskiy, A., Oliver, J., Olson, T., Paley, J., Pandey, P., Para, A., Patterson, R. B., Pawloski, G., Pearson, N., Perevalov, D., Pershey, D., Peterson, E., Petti, R., Phan-Budd, S., Piccoli, L., Pla-Dalmau, A., Plunkett, R. K., Poling, R., Potukuchi, B., Psihas, F., Pushka, D., Qiu, X., Raddatz, N., Radovic, A., Rameika, R. A., Ray, R., Rebel, B., Rechenmacher, R., Reed, B., Reilly, R., Rocco, D., Rodkin, D., Ruddick, K., Rusack, R., Ryabov, V., Sachdev, K., Sahijpal, S., Sahoo, H., Samoylov, O., Sanchez, M. C., Saoulidou, N., Schlabach, P., Schneps, J., Schroeter, R., Sepulveda-Quiroz, J., Shanahan, P., Sherwood, B., Sheshukov, A., Singh, J., Singh, V., Smith, A., Smith, D., Smolik, J., Solomey, N., Sotnikov, A., Sousa, A., Soustruznik, K., Stenkin, Y., Strait, M., Suter, L., Talaga, R. L., Tamsett, M. C., Tariq, S., Tas, P., Tesarek, R. J., Thayyullathil, R. B., Thomsen, K., Tian, X., Tognini, S. C., Toner, R., Trevor, J., Tzanakos, G., Urheim, J., Vahle, P., Valerio, L., Vinton, L., Vrba, T., Waldron, A. V., Wang, B., Wang, Z., Weber, A., Wehmann, A., Whittington, D., Wilcer, N., Wildberger, R., Wildman, D., Williams, K., Wojcicki, S. G., Wood, K., Xiao, M., Xin, T., Yadav, N., Yang, S., Zadorozhnyy, S., Zalesak, J., Zamorano, B., Zhao, A., Zirnstein, J., and Zwaska, R.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report results from the first search for $\nu_\mu\to\nu_e$ transitions by the NOvA experiment. In an exposure equivalent to $2.74\times10^{20}$ protons-on-target in the upgraded NuMI beam at Fermilab, we observe 6 events in the Far Detector, compared to a background expectation of $0.99\pm0.11$ (syst.) events based on the Near Detector measurement. A secondary analysis observes 11 events with a background of $1.07\pm0.14$ (syst.). The $3.3\sigma$ excess of events observed in the primary analysis disfavors $0.1\pi < \delta_{CP} < 0.5\pi$ in the inverted mass hierarchy at the 90% C.L., Comment: 7 pages, 4 figures. Minor updates to match version accepted by journal

Published
2016
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