86 results on '"Prue Hill"'
Search Results
52. Delayed renal allograft failure due to polyoma-virus-associated tubulointerstitial nephritis
- Author
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H. Regele, D.G. Goodman, Prue Hill, and M. Robbie
- Subjects
Pathology ,medicine.medical_specialty ,Tumor Virus Infections ,business.industry ,Acute kidney injury ,Renal allograft ,Medicine ,business ,medicine.disease ,Tubulointerstitial Nephritis ,Polyomavirus Infections ,Kidney transplantation ,Pathology and Forensic Medicine - Published
- 2003
53. Late-onset warfarin necrosis
- Author
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Prue Hill, Peter Foley, Christopher M. Baker, and Catherine E Scarff
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Adult ,medicine.medical_specialty ,Time Factors ,Low protein ,Late onset ,Dermatology ,Severity of Illness Index ,Drug Administration Schedule ,Necrosis ,Fatal Outcome ,Skin Ulcer ,medicine ,Humans ,cardiovascular diseases ,Postoperative Care ,Calciphylaxis ,Dose-Response Relationship, Drug ,Septic shock ,business.industry ,Biopsy, Needle ,Rheumatic Heart Disease ,Warfarin ,Skin ulcer ,medicine.disease ,Surgery ,Aortic Valve ,Heart Valve Prosthesis ,Disease Progression ,Mitral Valve ,Vancomycin ,Female ,medicine.symptom ,Panniculitis ,business ,medicine.drug - Abstract
A 43-year-old woman developed tenderness and induration of her thighs and lower abdomen, 56 days after commencing warfarin for aortic and mitral valve replacements. Investigations showed elevated inflammatory markers, mild renal impairment, normal echocardiogram and low protein C and S levels consistent with warfarin therapy. Three weeks later, purpuric areas evolved into large tender haemoserous bullae, which broke down to form ulcers. Histology confirmed the clinical impression of warfarin-induced skin necrosis with dermal and subcutaneous venular thrombi. Despite cessation of warfarin and commencement of heparin, the lesions progressed. When the patient became febrile, blood cultures grew Pseudomonas aeruginosa, which was treated with intravenous imipenem and vancomycin. Wound swabs grew methycillin-resistant Staphylococcus aureus and the antibiotics were changed. The patient developed septic shock and, despite intensive care management, her condition deteriorated and she died 9 weeks after the onset of the skin symptoms.
- Published
- 2002
54. Effects of Tamoxifen and oestrogen on histology and radiographic density in high and low mammographic density human breast tissues maintained in murine tissue engineering chambers
- Author
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Kara L. Britt, Michael A. Henderson, Erik W. Thompson, Jennifer N. Cawson, David C.S. Huang, Melissa C. Southey, H. Frazer, Tony Blick, J. L. Hopper, G. L. Chew, Cecilia W. Huo, Izhak Haviv, and Prue Hill
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Stromal cell ,Antineoplastic Agents, Hormonal ,Transplantation, Heterologous ,Adipose tissue ,Breast Neoplasms ,Mice, SCID ,Mice ,Breast cancer ,Medicine ,Endocrine system ,Animals ,Humans ,skin and connective tissue diseases ,Mammary Glands, Human ,Breast Density ,Tissue Engineering ,business.industry ,Histology ,Estrogens ,medicine.disease ,Transplantation ,Tamoxifen ,Oncology ,Tissue Transplantation ,Female ,business ,Hormone ,medicine.drug ,Mammography - Abstract
Mammographic density (MD) is a strong risk factor for breast cancer. It is altered by exogenous endocrine treatments, including hormone replacement therapy and Tamoxifen. Such agents also modify breast cancer (BC) risk. However, the biomolecular basis of how systemic endocrine therapy modifies MD and MD-associated BC risk is poorly understood. This study aims to determine whether our xenograft biochamber model can be used to study the effectiveness of therapies aimed at modulating MD, by examine the effects of Tamoxifen and oestrogen on histologic and radiographic changes in high and low MD tissues maintained within the biochamber model. High and low MD human tissues were precisely sampled under radiographic guidance from prophylactic mastectomy fresh specimens of high-risk women, then inserted into separate vascularized murine biochambers. The murine hosts were concurrently implanted with Tamoxifen, oestrogen or placebo pellets, and the high and low MD biochamber tissues maintained in the murine host environment for 3 months, before the high and low MD biochamber tissues were harvested for histologic and radiographic analyses. The radiographic density of high MD tissue maintained in murine biochambers was decreased in Tamoxifen-treated mice compared to oestrogen-treated mice (p = 0.02). Tamoxifen treatment of high MD tissue in SCID mice led to a decrease in stromal (p = 0.009), and an increase in adipose (p = 0.023) percent areas, compared to placebo-treated mice. No histologic or radiographic differences were observed in low MD biochamber tissue with any treatment. High MD biochamber tissues maintained in mice implanted with Tamoxifen, oestrogen or placebo pellets had dynamic and measurable histologic compositional and radiographic changes. This further validates the dynamic nature of the MD xenograft model, and suggests the biochamber model may be useful for assessing the underlying molecular pathways of Tamoxifen-reduced MD, and in testing of other pharmacologic interventions in a preclinical model of high MD.
- Published
- 2014
55. Spectrum of renal disease in diabetes
- Author
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Jessie, Teng, Karen M, Dwyer, Prue, Hill, Emily, See, Elif I, Ekinci, George, Jerums, and Richard J, MacIsaac
- Subjects
Adult ,Male ,Biopsy ,Comorbidity ,Middle Aged ,Kidney ,Prognosis ,Young Adult ,Predictive Value of Tests ,Risk Factors ,Diabetes Mellitus ,Humans ,Diabetic Nephropathies ,Female ,Kidney Diseases ,Aged - Abstract
The spectrum of renal disease in patients with diabetes encompasses both diabetic kidney disease (including albuminuric and non-albuminuric phenotypes) and non-diabetic kidney disease. Diabetic kidney disease can manifest as varying degrees of renal insufficiency and albuminuria, with heterogeneity in histology reported on renal biopsy. For patients with diabetes and proteinuria, the finding of non-diabetic kidney disease alone or superimposed on the changes of diabetic nephropathy is increasingly reported. It is important to identify non-diabetic kidney disease as some forms are treatable, sometimes leading to remission. Clinical indications for a heightened suspicion of non-diabetic kidney disease and hence consideration for renal biopsy in patients with diabetes and nephropathy include absence of diabetic retinopathy, short duration of diabetes, atypical chronology, presence of haematuria or other systemic disease, and the nephrotic syndrome.
- Published
- 2014
56. Anti-GBM disease following CTLA4 blockade in a patient with metastatic melanoma
- Author
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David Goodman, Christine Sammartino, Grant Flanagan, and Prue Hill
- Subjects
Transplantation ,Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,urogenital system ,business.industry ,medicine.medical_treatment ,Glomerular basement membrane ,Melanoma ,chemical and pharmacologic phenomena ,Glomerulonephritis ,Immunotherapy ,medicine.disease ,Metastasis ,medicine.anatomical_structure ,Antigen ,Nephrology ,Medicine ,Renal biopsy ,business ,Tremelimumab ,medicine.drug - Abstract
Cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) antagonists are currently being investigated in patients with metastatic malignant melanoma. It is proposed that this therapy will upregulate T-cell responses to melanoma cells while simultaneously targeting regulatory T lymphocytes (Tregs) which are known to suppress the host’s immune response to cancer cells. In some of these patients, immune-mediated adverse events such as enterocolitis, dermatitis, uveitis and hepatitis have been observed. We report a case of a 50-year-old man presenting with cough, fever, macroscopic haematuria and oligoanuric kidney failure following treatment with the CTLA4 antagonist tremelimumab for metastatic malignant melanoma. Kidney biopsy demonstrated crescentic glomerulonephritis and strong linear glomerular basement membrane (GBM) staining for IgG and C3; serum anti-GBM antibody level was markedly elevated (>200 U/ml).
- Published
- 2009
57. Mantle Cell Lymphoma with Bilateral Palpable Breast Masses
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Prue Hill and Melanie Seale
- Subjects
Aged, 80 and over ,Oncology ,medicine.medical_specialty ,Pathology ,business.industry ,Breast Neoplasms ,Lymphoma, Mantle-Cell ,medicine.disease ,Lymphoma ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Female ,Surgery ,Mantle cell lymphoma ,business - Published
- 2008
58. An unusual glomerulopathy in a man with HIV infection on HAART
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Robyn G Langham, Prue Hill, and Michael Desmond
- Subjects
Renal lesion ,business.industry ,Human immunodeficiency virus (HIV) ,virus diseases ,urologic and male genital diseases ,medicine.disease ,medicine.disease_cause ,Virology ,Pathology and Forensic Medicine ,Nephropathy ,Focal glomerulosclerosis ,Glomerulopathy ,medicine ,business - Abstract
Sir,Human immunodeficiency virus (HIV) infection is associated with a specific renal lesion HIV-associated nephropathy (HIVAN), a collapsing form of focal glomerulosclerosis (FGS) that presents wit...
- Published
- 2008
59. Collagenous spherulosis with lobular carcinoma in situ: a potential diagnostic pitfall
- Author
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Jennifer N. Cawson and Prue Hill
- Subjects
In situ ,Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Lobular carcinoma ,Breast lesion ,medicine.disease ,Pathology and Forensic Medicine ,Lesion ,Collagenous spherulosis ,Carcinoma ,Immunohistochemistry ,Medicine ,Mammography ,medicine.symptom ,skin and connective tissue diseases ,business - Abstract
Sir,Collagenous spherulosis is a rare, benign breast lesion occurring in less than 1% of benign breast biopsies. Collagenous spherulosis was first described by Clement et al.1 as a lesion often see...
- Published
- 2007
60. Dynamic changes in high and low mammographic density human breast tissues maintained in murine tissue engineering chambers during various murine peripartum states and over time
- Author
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Melissa C. Southey, David C.S. Huang, Tony Blick, Izhak Haviv, Prue Hill, Cecilia W. Huo, Jennifer N. Cawson, H. Frazer, Erik W. Thompson, Michael A. Henderson, J. L. Hopper, and G. L. Chew
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Stromal cell ,Adipose tissue ,Breast Neoplasms ,Mice ,Breast cancer ,Stroma ,Pregnancy ,Lactation ,Peripartum Period ,Medicine ,Animals ,Humans ,Breast ,Mammary Glands, Human ,Breast Density ,Tissue Engineering ,business.industry ,medicine.disease ,medicine.anatomical_structure ,Oncology ,Female ,business ,Hormone ,Mammography - Abstract
Mammographic density (MD) is a strong heritable risk factor for breast cancer, and may decrease with increasing parity. However, the biomolecular basis for MD-associated breast cancer remains unclear, and systemic hormonal effects on MD-associated risk is poorly understood. This study assessed the effect of murine peripartum states on high and low MD tissue maintained in a xenograft model of human MD. Method High and low MD human breast tissues were precisely sampled under radiographic guidance from prophylactic mastectomy specimens of women. The high and low MD tissues were maintained in separate vascularised biochambers in nulliparous or pregnant SCID mice for 4 weeks, or mice undergoing postpartum involution or lactation for three additional weeks. High and low MD biochamber material was harvested for histologic and radiographic comparisons during various murine peripartum states. High and low MD biochamber tissues in nulliparous mice were harvested at different timepoints for histologic and radiographic comparisons. Results High MD biochamber tissues had decreased stromal (p = 0.0027), increased adipose (p = 0.0003) and a trend to increased glandular tissue areas (p = 0.076) after murine postpartum involution. Stromal areas decreased (p = 0.042), while glandular (p = 0.001) and adipose areas (p = 0.009) increased in high MD biochamber tissues during lactation. A difference in radiographic density was observed in high (p = 0.0021) or low MD biochamber tissues (p = 0.004) between nulliparous, pregnant and involution groups. No differences in tissue composition were observed in high or low MD biochamber tissues maintained for different durations, although radiographic density increased over time. Conclusion High MD biochamber tissues had measurable histologic changes after postpartum involution or lactation. Alterations in radiographic density occurred in biochamber tissues between different peripartum states and over time. These findings demonstrate the dynamic nature of the human MD xenograft model, providing a platform for studying the biomolecular basis of MD-associated cancer risk.
- Published
- 2013
61. An unusual breast tumour occurring six years after a similar tumour in the contralateral breast
- Author
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Prue Hill, Ralph A. Zito, and David W. Ellis
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,medicine ,Contralateral breast ,business ,Pathology and Forensic Medicine - Published
- 2004
62. c-kit expression in adenoid cystic carcinoma of the breast
- Author
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Prue Hill
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Adenoid cystic carcinoma ,Keratin 7 ,Carcinoma ,medicine ,Immunohistochemistry ,medicine.disease ,business ,Pathology and Forensic Medicine - Published
- 2004
63. Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme
- Author
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Anna J. Lomax, Prue Hill, and David M. Ashley
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Thrombotic microangiopathy ,Bevacizumab ,Angiogenesis ,Interstitial nephritis ,Biopsy ,Renal function ,Angiogenesis Inhibitors ,urologic and male genital diseases ,Antibodies, Monoclonal, Humanized ,Gastroenterology ,Internal medicine ,Medicine ,Humans ,Pharmacology (medical) ,Glucocorticoids ,Proteinuria ,medicine.diagnostic_test ,business.industry ,Brain Neoplasms ,Middle Aged ,medicine.disease ,Discontinuation ,Oncology ,Nephritis, Interstitial ,medicine.symptom ,Neoplasm Recurrence, Local ,business ,Glioblastoma ,medicine.drug - Abstract
Glioblastoma multiforme is an aggressive malignant brain tumor. The monoclonal antibody, bevacizumab, is active in recurrent disease via inhibition of angiogenesis. Proteinuria and renal thrombotic microangiopathy are known complications. We report a case of a patient developing acute renal failure with biopsy-proven interstitial nephritis while receiving bevacizumab for recurrent disease. The patient was otherwise well with a history of controlled hypertension. Renal function improved with discontinuation of bevacizumab and the administration of corticosteroid therapy.
- Published
- 2012
64. Nephrology: Instructive case haemorrhagic cystitis due to BK virus in an adult with cardiac & pulmonary sarcoidosis
- Author
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Matthew Conron, David Clarke, David Goodman, Andrew I. MacIsaac, Prue Hill, and William G Martin
- Subjects
Nephrology ,medicine.medical_specialty ,Pathology ,Tumor Virus Infections ,business.industry ,Virus Activation ,General Medicine ,medicine.disease ,medicine.disease_cause ,BK virus ,Pulmonary sarcoidosis ,Instructive case ,Internal medicine ,medicine ,Sarcoidosis ,business ,Polyomavirus Infections - Published
- 2016
65. Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells
- Author
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Bryce J. W. van Denderen, Randy Suryadinata, N. P. A. Devika Gunasinghe, Yvette Drabsch, Thomas J. Gonda, Lloyd Pereira, Erik W. Thompson, Boris Sarcevic, Donald F. Newgreen, Eliza T. L. Soo, Robert G. Ramsay, Prue Hill, Cletus Pinto, Honor J. Hugo, Hugo, Honor J, Pereira, Lloyd, Suryadinata, Randy, Drabsch, Yvette, Gonda, Thomas J, Gunasinghe, NPA Devika, Pinto, Cletus, Soo, Eliza TL, van Denderen, Bryce JW, Hill, Prue, Ramsay, Robert G, Sarcevic, Boris, Newgreen, Donald F, and Thompson, Erik W
- Subjects
Epithelial-Mesenchymal Transition ,MYB ,Breast Neoplasms ,Cell morphology ,Small hairpin RNA ,Proto-Oncogene Proteins c-myb ,Epidermal growth factor ,Tumor Cells, Cultured ,Medicine ,Humans ,Epithelial–mesenchymal transition ,RNA, Small Interfering ,Promoter Regions, Genetic ,Cell Proliferation ,Medicine(all) ,Regulation of gene expression ,Homeodomain Proteins ,Gene knockdown ,business.industry ,Zinc Finger E-box-Binding Homeobox 1 ,Gene Expression Regulation, Neoplastic ,Cancer research ,Female ,business ,breast cancer cells ,Transcription Factors ,Research Article - Abstract
Introduction: Epithelial-to-mesenchymal transition (EMT) promotes cell migration and is important in metastasis. Cellular proliferation is often downregulated during EMT, and the reverse transition (MET) in metastases appears to be required for restoration of proliferation in secondary tumors. We studied the interplay between EMT and proliferation control by MYB in breast cancer cells.Methods: MYB, ZEB1, and CDH1 expression levels were manipulated by lentiviral small-hairpin RNA (shRNA)-mediated knockdown/overexpression, and verified with Western blotting, immunocytochemistry, and qRT-PCR. Proliferation was assessed with bromodeoxyuridine pulse labeling and flow cytometry, and sulforhodamine B assays. EMT was induced with epidermal growth factor for 9 days or by exposure to hypoxia (1% oxygen) for up to 5 days, and assessed with qRT-PCR, cell morphology, and colony morphology. Protein expression in human breast cancers was assessed with immunohistochemistry. ZEB1-MYB promoter binding and repression were determined with Chromatin Immunoprecipitation Assay and a luciferase reporter assay, respectively. Student paired t tests, Mann-Whitney, and repeated measures two-way ANOVA tests determined statistical significance (P < 0.05).Results: Parental PMC42-ET cells displayed higher expression of ZEB1 and lower expression of MYB than did the PMC42-LA epithelial variant. Knockdown of ZEB1 in PMC42-ET and MDA-MB-231 cells caused increased expression of MYB and a transition to a more epithelial phenotype, which in PMC42-ET cells was coupled with increased proliferation. Indeed, we observed an inverse relation between MYB and ZEB1 expression in two in vitro EMT cell models, in matched human breast tumors and lymph node metastases, and in human breast cancer cell lines. Knockdown of MYB in PMC42-LA cells (MYBsh-LA) led to morphologic changes and protein expression consistent with an EMT. ZEB1 expression was raised in MYBsh-LA cells and significantly repressed in MYB-overexpressing MDA-MB-231 cells, which also showed reduced random migration and a shift from mesenchymal to epithelial colony morphology in two dimensional monolayer cultures. Finally, we detected binding of ZEB1 to MYB promoter in PMC42-ET cells, and ZEB1 overexpression repressed MYB promoter activity.Conclusions: This work identifies ZEB1 as a transcriptional repressor of MYB and suggests a reciprocal MYB-ZEB1 repressive relation, providing a mechanism through which proliferation and the epithelial phenotype may be coordinately modulated in breast cancer cells. Refereed/Peer-reviewed
- Published
- 2012
66. Clofazimine-induced enteropathy in treatment-resistant nodular vasculitis
- Author
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Violet, Kieu, Richard, Williams, Prue, Hill, and Rob, Kelly
- Subjects
Adult ,Vasculitis ,Intestinal Diseases ,Prednisolone ,Anti-Inflammatory Agents, Non-Steroidal ,Antitubercular Agents ,Humans ,Drug Therapy, Combination ,Female ,Erythema Induratum ,Treatment Failure ,Clofazimine ,Glucocorticoids - Abstract
We report a chronic case of nodular vasculitis that responded to oral clofazimine 300 mg daily. The condition had previously responded to moderate dose oral prednisolone, 50 mg daily, but would recur with weaning. Multiple corticosteroid-sparing agents were trialled, however these were either ineffective or poorly tolerated. The introduction of clofazimine enabled prednisolone dose reduction, not achieved with other agents, to 22.5 mg daily, and was associated with complete suppression of disease activity. Unfortunately the patient developed a clofazimine-induced enteropathy and the treatment was ceased after almost 2 years of therapy. Cessation of clofazimine was associated with a flare of the condition. Clofazimine should be considered as a corticosteroid-sparing agent in resistant cases of nodular vasculitis. Clinicians should be aware of clofazimine-induced enteropathy as a potentially serious complication of the therapy.
- Published
- 2012
67. Melatonin attenuates colistin-induced nephrotoxicity in rats
- Author
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Jumana Mohammad Yousef, Jian Li, Roger L. Nation, Prue Hill, and Gong Chen
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Antibiotics ,Pharmacology ,Biology ,Kidney ,Nephrotoxicity ,Melatonin ,Excretion ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Pharmacokinetics ,Internal medicine ,Acetylglucosaminidase ,medicine ,polycyclic compounds ,Animals ,Pharmacology (medical) ,Experimental Therapeutics ,Creatinine ,Colistin ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,Rats ,Infectious Diseases ,medicine.anatomical_structure ,Endocrinology ,chemistry ,bacteria ,lipids (amino acids, peptides, and proteins) ,medicine.drug - Abstract
Colistin-induced nephrotoxicity is a dose-limiting adverse effect when colistin is used against Gram-negative pathogens. This study examined the nephroprotective effect of melatonin against colistin in rats. Rats ( n = 7 per group) were treated intravenously twice daily with saline, colistin (at increasing doses from 0.5 to 4.0 mg/kg), melatonin (5 mg/kg), or both melatonin and colistin for 7 days. The severity of renal alteration was examined both biochemically and histologically. The effect of coadministration of melatonin on colistin pharmacokinetics was investigated. Significantly lower urinary N -acetyl-β- d -glucosaminidase excretion was observed from day 1 in the colistin-melatonin group compared to the colistin group ( P < 0.0001). Plasma creatinine increased significantly ( P = 0.023) only in the colistin group on day 6. Significant histological abnormalities ( P < 0.0001) were detected only in the kidneys of the colistin group. Melatonin altered colistin pharmacokinetics; the total body clearance in the colistin-melatonin group (1.82 ± 0.26 ml/min/kg) was lower than in the colistin group (4.28 ± 0.93 ml/min/kg). This is the first study demonstrating the protective effect of melatonin against colistin-induced nephrotoxicity, which indicates that colistin-induced nephrotoxicity is mediated through oxidative stress. It also highlights the potential of coadministering an antioxidant to widen the therapeutic window of this very important last-line antibiotic.
- Published
- 2011
68. Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype
- Author
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Adam Winterhalter, Glen A. Doherty, Silvia Deaglio, Dusan Hanidziar, Prabhakar Putheti, Prue Hill, Sandra Pommey, Jennifer L. McRae, Simon C. Robson, Maria Koulmanda, Karen M. Dwyer, Terry B. Strom, and Wenda Gao
- Subjects
CD4-Positive T-Lymphocytes ,Graft Rejection ,CD4 regulatory cells ,Population ,chemical and pharmacologic phenomena ,Biology ,T-Lymphocytes, Regulatory ,regulatory T cells ,renal allograft rejection ,Article ,Proinflammatory cytokine ,Interferon-gamma ,Immune system ,Antigens, CD ,T-Lymphocyte Subsets ,medicine ,Immunology and Allergy ,Humans ,Pharmacology (medical) ,Interferon gamma ,IL-2 receptor ,Pyrophosphatases ,renal allograft ,education ,Transplantation ,education.field_of_study ,Apyrase ,Interleukin-17 ,Interleukin-2 Receptor alpha Subunit ,FOXP3 ,hemic and immune systems ,T lymphocyte ,Kidney Transplantation ,Phenotype ,Immunology ,CD4 Antigens ,Kidney Failure, Chronic ,Th17 Cells ,Interleukin 17 ,Immunologic Memory ,medicine.drug - Abstract
We have shown that CD39 and CD73 are co-expressed on the surface of murine CD4+Foxp3+ regulatory T cells (Treg) and generate extracellular adenosine, contributing to Treg immunosuppressive activity. We now describe that CD39, independently of CD73, is expressed by a subset of blood derived human CD4+CD25+CD127lo T regulatory cells (Treg), defined by robust expression of Foxp3. A further distinct population of CD4+CD39+ T lymphocytes can be identified, which do not express CD25 and FoxP3 and exhibit the memory effector cellular phenotype. Differential expression of CD25 and CD39 on circulating CD4+ T cells distinguishes between Treg and pathogenic cellular populations that secrete pro-inflammatory cytokines such as IFNγ and IL-17. These latter cell populations are increased, with a concomitant decrease in the CD4+CD25+CD39+ Tregs, in the peripheral blood of patients with renal allograft rejection. We conclude that the ectonucleotidase CD39 is a useful and dynamic lymphocytes surface marker that can be used to identify different peripheral blood T cell populations to allow tracking of these in health and disease, as in renal allograft rejection.
- Published
- 2010
69. Inflammatory pseudotumor of the breast: a mimic of breast carcinoma
- Author
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Prue Hill
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,Middle Aged ,medicine.disease ,Granuloma, Plasma Cell ,Diagnosis, Differential ,Breast Diseases ,Breast cancer ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Surgery ,Female ,Breast carcinoma ,business - Published
- 2010
70. Acute kidney injury and proteinuria in a patient with diabetes and a submandibular mass
- Author
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Katherine Wiggins, Prue Hill, Christine Sammartino, Karen M. Dwyer, and Prue Russell
- Subjects
Nephrology ,Male ,medicine.medical_specialty ,Interstitial nephritis ,Urology ,Sialadenitis ,Autoimmune Diseases ,Diabetes Complications ,Internal medicine ,Diabetes mellitus ,Submandibular Gland Diseases ,medicine ,Humans ,Type 1 diabetes ,Proteinuria ,business.industry ,Acute kidney injury ,Acute Kidney Injury ,Middle Aged ,medicine.disease ,Surgery ,Nephritis, Interstitial ,medicine.symptom ,business ,Nephritis ,Kidney disease - Published
- 2008
71. Collagenous spherulosis presenting as a mass lesion on imaging
- Author
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Jennifer N. Cawson and Prue Hill
- Subjects
medicine.medical_specialty ,Mass/lesion ,medicine.diagnostic_test ,business.industry ,Biopsy, Needle ,Middle Aged ,medicine.disease ,Breast Diseases ,Text mining ,Collagenous spherulosis ,Oncology ,Biopsy ,Internal Medicine ,medicine ,Mammography ,Humans ,Surgery ,Female ,Radiology ,Breast ,Collagen ,business - Published
- 2008
72. Can mammographic findings help discriminate between atypical ductal hyperplasia and ductal carcinoma in situ after needle core biopsy?
- Author
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Prue Hill, Jenny K. Hoang, and Jennifer N. Cawson
- Subjects
Adult ,medicine.medical_specialty ,Pathology ,Population ,Breast Neoplasms ,Malignancy ,Diagnosis, Differential ,medicine ,Carcinoma ,Mammography ,Humans ,education ,Mammary Glands, Human ,Aged ,education.field_of_study ,Hyperplasia ,medicine.diagnostic_test ,business.industry ,Calcinosis ,General Medicine ,Odds ratio ,Ductal carcinoma ,Middle Aged ,medicine.disease ,Carcinoma, Intraductal, Noninfiltrating ,Surgery ,Female ,Radiology ,Microcalcification ,medicine.symptom ,business ,Precancerous Conditions ,Calcification - Abstract
In a screening population of women, the mammographic characteristics for 68 cases of atypical ductal hyperplasia (ADH) diagnosed by needle core biopsy (NCB) were reviewed to seek mammographic findings which differentiate between ductal carcinoma in situ (DCIS) and ADH. A blinded analysis by two radiologists was performed for 48 cases with microcalcification. The mammographic findings were correlated with the surgical histological results of benign non-atypical, ADH and carcinoma (DCIS or invasive) to identify features which were associated with a higher or lower odds ratio (OR) for malignancy. Underestimates for malignancy occurred in 14 of 29 cases with granular calcification form (OR 7.9, 95% confidence interval (CI) 1.5–41) and 6 of 8 cases with segmental/linear branching distribution (OR 9.0, 95%CI 1.6–52). No malignancy was found at surgical excision in 16 cases with fine, rounded calcification. In conclusion, detailed assessment of calcification distribution and form gave helpful predictors for malignancy. Lesions with fine rounded calcification were always benign.
- Published
- 2007
73. Renal cell carcinoma metastasis to the breast: mammographic, sonographic, CT, and pathologic correlation
- Author
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Jenny K. Hoang, Jennifer N. Cawson, Wai-Kit Lee, Hannah Rouse, and Prue Hill
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Breast Neoplasms ,medicine.disease ,Kidney Neoplasms ,Metastasis ,Oncology ,Pathologic correlation ,Renal cell carcinoma ,Internal Medicine ,medicine ,Carcinoma ,Mammography ,Humans ,Surgery ,Female ,Radiology ,Ultrasonography ,business ,Carcinoma, Renal Cell ,Aged - Published
- 2007
74. Abstract P4-04-11: Comparing tissue compositions of within-individual mammographically high and low dense breast tissue
- Author
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Kara L. Britt, Michael A. Henderson, Dexing Huang, G. L. Chew, Prue Hill, Rik Thompson, Wendy V. Ingman, and Cecilia W. Huo
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Breast tissue ,Oncology ,business.industry ,Medicine ,business - Abstract
Abstract Purpose Mammographic density (MD) refers to the extent of radio-opaque breast tissue on a mammogram. Adjusted for a women’s age and body mass index (BMI), it is a strong and independent risk factor for breast cancer (BC). The presentation of mammographically dense breast is not uncommon in the normal female population, and patients’ awareness of its association with BC risk has been growing following mandatory reporting of MD by physicians in several states of America. Women with breasts that have over 75% dense tissue are 4 to 6 times more likely to develop BC than women with breasts that have less than 10% dense tissue. However, the biological basis of how high MD raises BC risk remains elusive. We aimed to examine the histological and molecular differences between high and low dense breast tissues of healthy women, using specimens accrued from prophylactic mastectomy procedures. Method 48 women between 2008 and 2013 underwent prophylactic mastectomy at St Vincent’s Hospital and Peter MacCallum Cancer Centre due to a high BC risk profile. Of these, 41 were eligible for analyses. Tissue slice resected from the mastectomy specimen was X-rayed, and high (HD) and low dense (LD) regions were dissected based on the radiological appearance. The histological composition, immunohistochemistry and proliferation status were assessed on matched high and low MD tissue of the same breast. Signed rank test and paired t test were used for quantitative analyses of potential differences between HD and LD tissue. Result HD tissue demonstrated a significantly greater proportion of stroma (p Conclusion and Significance We found that increased stroma and epithelium proportions contribute to the dense appearance on mammogram. Moreover, dense tissue did not demonstrate differed hormonal receptor expression or proliferation status from non-dense tissue, but showed a preponderance of EMT in the form of co-localisation by both CK-19 and vimentin in some of the epithelial cells. Our study is the first to report EMT phenomenon in benign mammary tissue, and suggests that investigations of the stromal micro-environment, and their interactions with epithelium may be key to improving our understanding on MD-mediated BC risk. Citation Format: Cecilia W Huo, Dexing Huang, Grace L Chew, Prue Hill, Wendy V Ingman, Michael Henderson, Kara L Britt, Rik Thompson. Comparing tissue compositions of within-individual mammographically high and low dense breast tissue [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-04-11.
- Published
- 2015
75. Margins and outcome of screen-detected breast cancer with extensive in situ component
- Author
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Pamela A. Wilkins, Suzanne E. Moore, Jennifer N. Cawson, Ann-Marie Power, Michael A. Henderson, Prue Hill, Paul R. B. Kitchen, and Toni M. Barbetti
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Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Breast Neoplasms ,Breast cancer ,medicine ,Carcinoma ,Mammography ,Humans ,Mastectomy ,Aged ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Carcinoma in situ ,Carcinoma, Ductal, Breast ,Retrospective cohort study ,General Medicine ,Ductal carcinoma ,Middle Aged ,medicine.disease ,Surgery ,Radiation therapy ,Treatment Outcome ,Female ,business ,Carcinoma in Situ - Abstract
Background: In situ disease surrounding invasive tumours is an important consideration in the management of patients with early breast cancer. This study of screen-detected breast cancers assessed the influence of in situ disease including an extensive in situ component (defined as ductal carcinoma in situ involving more than 25% of the area within the invasive tumour) on surgical management, local recurrence and survival of a group of patients. Methods: A total of 595 cases of invasive breast cancer detected at St Vincent’s BreastScreen were retrospectively reviewed to determine presence and extent of in situ disease, the surgical procedure and adequacy of excision. Outcome was examined in a cohort of 126 cases. Results: A total of 438 (74%) patients had in situ foci in or around the invasive tumour and 107 (18%) were defined as extensive in situ component (EIC)-positive. The initial procedure was mastectomy in 20% of the cases and breast-conserving surgery in 80% including 18% who underwent further surgery. Re-excision (P = 0.02) or mastectomy (P = 0.01) was more often required in patients with EIC. After definitive local excision, margins were close or involved with invasive disease in 3% but the patients with EIC were more likely to have margins close or involved with in situ disease (16 vs 2%; P = 0.001). There were seven deaths and one local invasive recurrence in the follow-up group and none of the deaths were in patients who were EIC-positive. Conclusions: EIC predicts for a higher rate of re-excision and/or mastectomy. For patients with EIC, there is an acceptably low risk of local recurrence if margins are clear.
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- 2006
76. Pathophysiologic Implications of Reduced Podocyte Number in a Rat Model of Progressive Glomerular Injury
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Hiroshi Kawachi, Prue Hill, Tiziana Plati, Maria Bonomelli, Giuseppe Remuzzi, Andrea Remuzzi, Lorena Longaretti, Ariela Benigni, Daniela Macconi, Fabio Sangalli, and Sara Conti
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Male ,Pathology ,medicine.medical_specialty ,Blotting, Western ,Renal function ,urologic and male genital diseases ,Article ,Pathology and Forensic Medicine ,Podocyte ,Nephropathy ,Nephrin ,Microscopy, Electron, Transmission ,medicine ,Animals ,RNA, Messenger ,Rats, Wistar ,Proteinuria ,biology ,urogenital system ,Glomerulosclerosis, Focal Segmental ,Podocytes ,Reverse Transcriptase Polymerase Chain Reaction ,Glomerulosclerosis ,Membrane Proteins ,Glomerular Hypertrophy ,medicine.disease ,Immunohistochemistry ,female genital diseases and pregnancy complications ,Rats ,Disease Models, Animal ,medicine.anatomical_structure ,Hypertension ,biology.protein ,Slit diaphragm ,Microscopy, Electron, Scanning ,medicine.symptom - Abstract
Changes in podocyte number or density have been suggested to play an important role in renal disease progression. Here, we investigated the temporal relationship between glomerular podocyte number and development of proteinuria and glomerulosclerosis in the male Munich Wistar Fromter (MWF) rat. We also assessed whether changes in podocyte number affect podocyte function and focused specifically on the slit diaphragm-associated protein nephrin. Age-matched Wistar rats were used as controls. Estimation of podocyte number per glomerulus was determined by digital morphometry of WT1-positive cells. MWF rats developed moderate hypertension, massive proteinuria, and glomerulosclerosis with age. Glomerular hypertrophy was already observed at 10 weeks of age and progressively increased thereafter. By contrast, mean podocyte number per glomerulus was lower than normal in young animals and further decreased with time. As a consequence, the capillary tuft volume per podocyte was more than threefold increased in older rats. Electron microscopy showed important changes in podocyte structure of MWF rats, with expansion of podocyte bodies surrounding glomerular filtration membrane. Glomerular nephrin expression was markedly altered in MWF rats and inversely correlated with both podocyte loss and proteinuria. Our findings suggest that reduction in podocyte number is an important determinant of podocyte dysfunction and progressive impairment of the glomerular permselectivity that lead to the development of massive proteinuria and ultimately to renal scarring.
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- 2006
77. ARF in 2 patients with long-standing type 2 diabetes mellitus
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Nigel Toussaint, Prue Hill, and David Barit
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Nephrology ,Adult ,Male ,medicine.medical_specialty ,Vascular disease ,business.industry ,Type 2 Diabetes Mellitus ,Type 2 diabetes ,Acute Kidney Injury ,Middle Aged ,medicine.disease ,Diabetic nephropathy ,Diabetes Complications ,Endocrinology ,Diabetes Mellitus, Type 2 ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,business ,Vasculitis ,Kidney disease - Published
- 2005
78. The incidence of biopsy-proven glomerulonephritis in Australia
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Priscilla Kincaid-Smith, John E. Dowling, Esther M. Briganti, Robert C. Atkins, Colin L. Jones, Prue Hill, Roger Sinclair, John J McNeil, and Moira Finlay
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Victoria ,Biopsy ,Population ,Lupus nephritis ,Age Distribution ,Glomerulonephritis ,Sex Factors ,medicine ,Humans ,Minimal change disease ,education ,Child ,Retrospective Studies ,Transplantation ,education.field_of_study ,Systemic lupus erythematosus ,medicine.diagnostic_test ,business.industry ,Incidence ,Australia ,medicine.disease ,Dermatology ,Nephrology ,Kidney Failure, Chronic ,Female ,Renal biopsy ,Vasculitis ,business ,Kidney disease - Abstract
Background There is limited population-based epidemiological data on renal disease. An insight into the spectrum of clinically significant glomerulonephritis can be obtained from renal biopsy diagnoses. This is a descriptive report of biopsy-proven glomerulonephritis within a defined population. Methods A retrospective review of the pathology reports of all native renal biopsies performed in the Australian state of Victoria in 1995 and 1997 was undertaken. Trends in the average annual age- and sex-specific incidence rates for biopsy-proven glomerulonephritis were calculated. Comparisons were made with the incidence of end-stage renal disease due to glomerulonephritis confirmed on renal biopsy. Results The most common glomerulonephritides in adults are IgA disease, focal glomerulosclerosis, lupus nephritis and vasculitis, and in children are lupus nephritis, focal glomerulosclerosis, IgA disease and minimal change disease. A male predominance is seen for all glomerulonephritides, except lupus nephritis, in both adults and children. An increase in incidence of disease with age, particularly in males, is seen for vasculitis and focal glomerulosclerosis. The most common glomerulonephritides on renal biopsy are reflected in the most common causes of end-stage renal disease due to glomerulonephritis. Conclusions This review has provided population-based descriptive epidemiological data on clinically significant glomerulonephritis. This data provides important clues for further studies relating to the identification of risk factors for the various types of glomerulonephritis.
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- 2001
79. MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS TYPE II (DENSE DEPOSIT DISEASE) IN ASSOCIATION WITH MONOCLONAL GAMMOPATHY
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Michael Desmond and Prue Hill
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Glomerulonephritis, Membranoproliferative ,business.industry ,Paraproteinemias ,General Medicine ,Monoclonal gammopathy ,Nephrology ,Immunology ,medicine ,Humans ,Dense Deposit Disease ,Membranoproliferative glomerulonephritis type II ,medicine.symptom ,business - Published
- 2007
80. A rare form of crescentic glomerulonephritis with mixed immunopathological features
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Prue Hill
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Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Crescentic glomerulonephritis ,Biopsy ,Medicine ,Glomerulonephritis ,business ,medicine.disease ,Pathology and Forensic Medicine - Published
- 2004
81. Acute renal failure - clinical studies - 1
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Oscar Fernando Pavão dos Santos, Raquel S. Kataoka, Catherine S. Forster, Sandeep Varma, Jayakrishnan Kizhakke Pisharam, Julio Cesar Martins Monte, Rama Tripathi, Kalpesh Gohel, Maksim Ilyinskiy, Yuji Nishizaki, Irina Aleksandrova, Anuradha Raman, J.A. Sastre, Jacob George, Sharon D. Ricardo, Nahme N.N. Karbage, Anna Tankiewicz-Kwedlo, Natália A. Rocha, Mohammad Shamim, Jung Sang Lee, Usha Singh, M. Muhibur Rahman, Catarina Santos, Antônio Augusto Guimarães, Hyo-Wook Gil, Ashutosh Soni, Tiago Carvalho, Yuanhan Chen, Stuart Jackson, Sajeev Kumar, Vytautas Razukas, Rong Liang, Prue Hill, Siddharth Mavani, Célio Barbosa, Carla Camila Bezerra, Jan Bakker, Miguel Cendoroglo, Weiping Xiong, Adrian Covic, Jonathan Barasch, David R. Walker, Oswaldo A. Gutiérrez-Adrianzén, Marcelino de Souza Durão, Dong Cheol Han, Mariana B Pereira, Gary Inglese, M. Nizamuddin Chowdhury, Shuangxin Liu, Jae Hak Kim, Faruk Turgut, P.G. Cosmes, Joao Coelho, Soon Hyo Kwon, Zoltan Huba Endre, Miyuki Futatsuyama, John W. Pickering, Alexandre Braga Libório, P.M. Escuer, Gabriela Laender Ferrari, Anna Zadovni, Marisol Pichardo, Sarasadat Moghadasimousavi, Marcelo Costa Batista, Thomas F. Mueller, Debabrata Sen, Kai Ott-Schmidt, Sudhidender Gupta, L.K. Sharatchandra, Elizabeth Verghese, J. L. M. L. Le Noble, Jong-Oh Yang, Elizabeth De Francesco Daher, Fumika Taki, James A. Deane, Paulo C. Carvalho Júnior, Michal Mysliwiec, R.N. Mishra, Lydmila Marchenkova, Connor Maguire, Masao Katayama, Eveline C. Silva, Eun Young Lee, Ramdas Pisharody, Nader Nouri-Majalan, G. Tabernero, Su-ji Kim, K. Little, Motaz Obeidat, E. Del Barrio, Beata Marie Redublo Quinto, Jackson Tan, Steve Coca, L.C. Sharma, Yasuhiro Komatsu, Sanjay Vikrant, Rosa Maria Salani Mota, Khalil Forouzannia, K. Kupfer, Polianna Lemos Moura Moreira Albuquerque, Hosein Moshtaghian, Vidhya Acharya, B. Noland, Ana Valesca Garcia, Sreepa Pulliyil, Robyn G Langham, Michelle J. C. Oliveira, Amit Gupta, Piotr Buczko, Miguel Angelo Goes, A. Gopal Kishan, Meghan E. Sise, Barbara Oliveira, Jin Nam Hyun, J.M. Tabernero, Krasnalhia Lívia S. Abreu, Robert S. Brown, Barry Hahn, Swarnalatha Gowrishankar, Jayant Hota, Regina C. R. M. Abdulkader, Maryam Nejat, Shailesh Gondane, Elton Diniz, Shriganesh Barnela, Erica Ferrand, Ehsan Fotohi, Marcos Reinaldo da Silva, Kyung Soo Kim, Heng Li, Yusuke Tsugawa, Jae Myun Jung, Sishir Gang, Mohan Rajapurkar, H. R. De Geus, Ilson Jorge Iizuka, Ali Akcay, Ferdous Kamal Bhuyan, Thomas L. Nickolas, V.G. Bernalt, Wei Shi, Anila Mathew, Jai Prakash, Adler Barreto, Xinling Liang, Sung Joon Shin, Valerie A. Luyckx, Marius Miglinas, Kelly Cristina Batista de Souto Queiroz, Silvia Santos, Katherine Forster, Dariusz Pawlak, C. Ince, Vinay Malhotra, Umapati Hegde, Geraldo Bezerra da Silva Junior, Elizabeth C. Verna, Luiz F. L. G. Franco, Kazuhiro Aoki, Sae-yong Hong, P.K. Srivastva, Julio C.M. Montes, Paulo Marcelino, Pankaj Beniwal, S.K. Behura, Luis Mourao, T. Garcia, Raj Kumar Sharma, Chirag R. Parikh, Karolis Skebas, P. Fraile, Anupma Kaul, Sergey Rei, Sachiko Ohde, Raphael Weidenfeld, Fernanda Melo, Agnieszka Buraczewska, Roberto Narciso, Biplab Ghosh, Anaiara Queiroz, Maria Aparecida Dalboni, Leandro F. Evangelista, Virgilio Gonçalves Pereira, Narayan Prasad, Jin Seok Jun, Yuki Kaneshiro, Hyunjin Noh, Sônia M. H. A. Araújo, Shashidhar Shreeniwas, Moacir de Oliveira, Keiichi Tamagaki, Mehmet Kanbay, and Rubina Vohra
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Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,medicine ,Intensive care medicine ,business - Published
- 2009
82. Severe early acute humoral rejection resulting in allograft loss in a renal transplant recipient with Campath-1H induction therapy.
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Prue Hill, Elena Gagliardini, Piero Ruggenenti, and Giuseppe Remuzzi
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- 2005
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83. Haemorrhagic Campylobacter jejuni and CMV colitis in a renal transplant recipient.
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Nigel Toussaint, David Goodman, Robyn Langham, Hilton Gock, and Prue Hill
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- 2005
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84. CD44-mediated neutrophil apoptosis in the rat
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Kazunori Takazoe, David J. Nikolic-Paterson, Hui Y. Lan, Zhao Jun, Prue Hill, Gregory H Tesch, Lynette A Hurst, and Robert C. Atkins
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Male ,Programmed cell death ,Neutrophils ,Lymphocyte ,Kidney Glomerulus ,Inflammation ,Apoptosis ,Biology ,In Vitro Techniques ,lymphocyte ,Antibodies ,Rats, Sprague-Dawley ,Annexin ,medicine ,Animals ,Cells, Cultured ,Autoantibodies ,Blood Cells ,Immune Sera ,intracellular signaling ,Antibodies, Monoclonal ,Glomerulonephritis ,Neutrophil extracellular traps ,medicine.disease ,Molecular biology ,infection ,Rats ,Microscopy, Electron ,medicine.anatomical_structure ,Hyaluronan Receptors ,cell death ,Nephrology ,Immunology ,monocyte ,biology.protein ,Kidney Diseases ,tubular epithelium ,medicine.symptom ,Antibody ,glomerulonephritis - Abstract
CD44-mediated neutrophil apoptosis in the rat. Background Apoptosis is an important mechanism by which neutrophils are removed from sites of inflammation, including the kidney. This study investigated whether ligation of the cell-surface adhesion molecule, CD44, can trigger neutrophil apoptosis. Methods The anti-rat CD44 antibody OX-50 was used to induce apoptosis of cultured blood neutrophils, as determined by flow cytometry using annexin V staining and by transmission electron microscopy. The functional consequences of OX-50–mediated neutrophil depletion were examined in a rat model of accelerated antiglomerular basement membrane glomerulonephritis. Results Flow cytometric analysis using the OX-50 antibody, which recognizes the common amino terminal domain of CD44, showed that rat blood neutrophils express very high levels of CD44. The addition of OX-50, but not control antibodies, rapidly induced neutrophil apoptosis in cultured rat blood leukocytes, as demonstrated by annexin V staining and by electron microscopy. Cross-linking of CD44 was essential since F(ab) fragments of the OX-50 antibody failed to induce neutrophil apoptosis. The CD44 ligand hyaluronan and an antibody to the CD44v6 isoform failed to induce neutrophil apoptosis, indicating that OX-50 antibody-mediated neutrophil apoptosis is epitope specific. This effect was specific to neutrophils since the OX-50 antibody did not induce apoptosis in other CD44-expressing cell types (lymphocytes, mesangial cells, or tubular epithelial cells). An injection of OX-50 antibody into normal rats caused a rapid and profound neutropenia, and apoptotic neutrophils could be seen in the blood by electron microscopy. Furthermore, the administration of OX-50 antibody abrogated neutrophil-dependent glomerular injury (proteinuria) on day 1 of rat antiglomerular basement membrane glomerulonephritis, whereas injury on day 10 of the disease (neutrophil independent) was largely unaffected. Conclusions The cross-linking of specific epitopes of the CD44 molecule can rapidly induce neutrophil apoptosis in vitro and inhibit neutrophil-dependent renal injury in vivo. This finding suggests that physiological ligands of the CD44 molecule may play an important role in eliminating neutrophils from sites of inflammation, including inflammatory kidney disease.
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85. Author reply.
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Jennifer N. Cawson, Prue Hill, and Michael Henderson
- Published
- 2004
86. BK virus RNA can be detected in archival renal transplant biopsies using the reverse trancription polymerase chain reaction.
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Kathryn J. Wiggins, Renae M. Gow, John Kanellis, Prue Hill, Darren J. Kelly, Alison Skene, David J. Goodman, and Robyn G. Langham
- Published
- 2009
- Full Text
- View/download PDF
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