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Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype
- Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 10(11)
- Publication Year :
- 2010
-
Abstract
- We have shown that CD39 and CD73 are co-expressed on the surface of murine CD4+Foxp3+ regulatory T cells (Treg) and generate extracellular adenosine, contributing to Treg immunosuppressive activity. We now describe that CD39, independently of CD73, is expressed by a subset of blood derived human CD4+CD25+CD127lo T regulatory cells (Treg), defined by robust expression of Foxp3. A further distinct population of CD4+CD39+ T lymphocytes can be identified, which do not express CD25 and FoxP3 and exhibit the memory effector cellular phenotype. Differential expression of CD25 and CD39 on circulating CD4+ T cells distinguishes between Treg and pathogenic cellular populations that secrete pro-inflammatory cytokines such as IFNγ and IL-17. These latter cell populations are increased, with a concomitant decrease in the CD4+CD25+CD39+ Tregs, in the peripheral blood of patients with renal allograft rejection. We conclude that the ectonucleotidase CD39 is a useful and dynamic lymphocytes surface marker that can be used to identify different peripheral blood T cell populations to allow tracking of these in health and disease, as in renal allograft rejection.
- Subjects :
- CD4-Positive T-Lymphocytes
Graft Rejection
CD4 regulatory cells
Population
chemical and pharmacologic phenomena
Biology
T-Lymphocytes, Regulatory
regulatory T cells
renal allograft rejection
Article
Proinflammatory cytokine
Interferon-gamma
Immune system
Antigens, CD
T-Lymphocyte Subsets
medicine
Immunology and Allergy
Humans
Pharmacology (medical)
Interferon gamma
IL-2 receptor
Pyrophosphatases
renal allograft
education
Transplantation
education.field_of_study
Apyrase
Interleukin-17
Interleukin-2 Receptor alpha Subunit
FOXP3
hemic and immune systems
T lymphocyte
Kidney Transplantation
Phenotype
Immunology
CD4 Antigens
Kidney Failure, Chronic
Th17 Cells
Interleukin 17
Immunologic Memory
medicine.drug
Subjects
Details
- ISSN :
- 16006143
- Volume :
- 10
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- Accession number :
- edsair.doi.dedup.....9d0dc46d15922237ff914927d7d9b7ee