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A randomized, placebo-controlled trial was carried out to determine the effectiveness of acebutolol in preventing late death in high-risk patients surviving an acute myocardial infarction (MI). The average 1-year mortality rate in placebo groups of 9 trials of beta blockers in post-MI patients was 7.2% compared with 17% in a nonselected cohort of patients who had survived at least 7 days after an MI. The mandate for this trial was based on the fact that high-risk patients whose mortality rate exceeds 20% have not been enrolled in significant numbers in previous trials. It remains to be proved whether beta-blocking therapy in this patient population is beneficial. Selection of high-risk patients for inclusion in the trial was based on an algorithm set up from the Essai de Prevention Secondaire de l'Infarctus du Myocarde Registry. At the time of the second interim analysis, the mortality rate in the placebo group was 12%, lower than expected (greater than or equal to 20%). The trial was stopped; at that time, 309 patients had been allocated to placebo and 298 patients to acebutolol therapy. After 318 days, there were 17 deaths in the acebutolol-treated group and 34 in the placebo group, a reduction in total mortality of 48% (p = 0.019). There were 30 vascular deaths in the placebo group and 12 in the acebutolol group. Thus, cardiovascular mortality with acebutolol was reduced by 58% (p = 0.006). The incidence of all cardiovascular-related deaths was lower in the acebutolol-treated group. The total reduction in mortality did not appear to be correlated with secondary risk factors.(ABSTRACT TRUNCATED AT 250 WORDS)

Acebutolol et Prévention Secondaire de l'Infarctus (APSI), a randomized, placebo-controlled trial, was designed to test long-term acebutolol, 200 mg twice daily, a beta blocker with mild intrinsic sympathomimetic activity, in the prevention of late death in high-risk postacute myocardial infarction (AMI) patients. APSI was planned because patients with a death rate greater than 20% have not been enrolled in significant numbers in previous trials and in such high-risk patients, it remained to be proven that beta blockers have a beneficial effect. Patients with an expected average risk of greater than 20% were to be selected based on clinical criteria. At the time of the second interim analysis, the placebo group 1-year mortality was much lower than expected (12%). The ethical board recommended to stop the trial: 309 patients had been allocated to placebo, 298 to acebutolol. The average delay between onset of symptoms and inclusion was 10.5 days. The average follow-up was 318 days after inclusion. About the same number of patients were discontinued from study treatment in both groups. All patients were included in the analysis. There were 17 deaths in the acebutolol group and 34 in the placebo group, a 48% decrease (p = 0.019). The vascular mortality decreased by 58% (p = 0.006), the highest ever observed with a beta blocker. All cardiovascular causes of death, including congestive heart failure, were less frequent in the acebutolol group. Although the objective was not achieved, APSI patients were at a higher risk than the average of the 9 previous trials with beta blockers (12% instead of 7%). In addition, the total mortality reduction did not decrease in 9 subgroups with increasing mortality risk from 2 to 23%. APSI shows that moderately severe postAMI patients can benefit from a beta-blocking treatment and a beta-blocker with mild intrinsic sympathomimetic activity can be effective.

A music emulator for emulating guitar sounds uses non-guitar like devices, as for instance a piano style keyboard, for input. Input from the keyboard within a time window is defined as simultaneous and entered into a note list. A signal is derived from the note list indicative of the chord played on the keyboard. In addition, notes in the note list can be extended to form a full chord whereby as few as three notes constituting a chord input at the keyboard are extended to a greater number of notes as, for instance, the six strings of a guitar. This signal is then outputted at a time rate which is extended with respect to the input time window whereby the output emulates a guitar strum including an arpeggiation or strumming effect of a guitar like sound. Chord extension is achieved by analyzing the notes in the note list as to their pitch and generating further notes which are outside the typical one octave range of a keyboard chord and extend to the typical four octave window of a guitar.

On montre que l'ordre d'exposition des idées du chapitre II du livre Γ des Météorologiques d'Aristote n'est pas satisfaisant, à cause de la place qu'y occupe le paragraphe sur l'arc-en-ciel lunaire (372 a 21-29). Ce passage, qui est probablement une adjonction tardive opérée par Aristote lui-même, devait primitivement être rattaché à l'exposition des faits relatifs à l'arc-en-ciel solaire (371 b 26-372 a 10), soit qu'il ait constitué une incise à l'intérieur de celle-ci (en 371 b 32), soit plutôt un appendice qui la suivait immédiatement (en 372 a 10)., Picolet Guy. Un paragraphe déplacé dans les « Météorologiques » d'Aristote (372 à 21-29). In: Revue des Études Anciennes. Tome 76, 1974, n°3-4. pp. 232-236.

SUMMARY. — Once again historians of science and technology are asked to appreciate the importance of the documents preserved in the Minutier central in Paris. To illustrate the usefulness of the Minutier central, the authors publish an extract from the inventory after death of the physicist Jacques Rohault, which enumerates the books and scientific instruments found in his home in February 1673. In the foot-notes they try to identify the books mentioned and describe the instruments listed in the inventory. The article ends with a few remarks on Rohaulťs library and scientific instruments., RÉSUMÉ. — L'attention des historiens des sciences et des techniques est une nouvelle fois attirée sur les ressources du Minutier central de Paris. On donne ensuite, à titre d'exemple d'utilisation, un extrait de l'inventaire après décès du physicien Jacques Rohault, concernant les livres et les instruments scientifiques qui ont été trouvés à son domicile après sa mort. Un essai d'identification de chacun des ouvrages cités dans l'inventaire, ainsi qu'une description sommaire des différents instruments mentionnés sont fournis en note. Quelques remarques sur la bibliothèque et les instruments scientifiques de Rohault concluent l'article., Mc Claughlin Trevor, Picolet Guy. Un exemple d'utilisation du Minutier central de Paris : la bibliothèque et les instruments scientifiques du physicien Jacques Rohault selon son inventaire après décès.. In: Revue d'histoire des sciences, tome 29, n°1, 1976. pp. 3-20.

RÉSUMÉ. — Historique des relations épistolaires de Jean Picard (1620- 1682) avec Johann Hevelius (1611-1687), puis édition, traduction française et annotation des six lettres latines échangées par les deux astronomes de 1671 à 1679.

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