126 results on '"Perivascular inflammation"'
Search Results
52. 1,2,3,4,6‐Penta‐ O ‐galloyl‐β‐ d ‐glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II‐induced hypertension
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Joanna Koziol, Delyth Graham, Anna K. Kiss, Amauri S. Justo‐Junior, Ryszard Nosalski, Zofia Kusmierczyk, Paulina Kowalczyk, Tomasz J. Guzik, Marek Naruszewicz, Dominik Skiba, Magdalena Mazur, Pasquale Maffia, Kevin Luc, Tomasz Mikolajczyk, Agata Schramm-Luc, Mikolajczyk, Tomasz P, Nosalski, Ryszard, Skiba, Dominik S, Koziol, Joanna, Mazur, Magdalena, Justo-Junior, Amauri S, Kowalczyk, Paulina, Kusmierczyk, Zofia, Schramm-Luc, Agata, Luc, Kevin, Maffia, Pasquale, Graham, Delyth, Kiss, Anna K, Naruszewicz, Marek, and Guzik, Tomasz J
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0301 basic medicine ,Male ,medicine.medical_specialty ,hypertension ,Injections, Subcutaneous ,Adipose tissue ,CCL2 ,CCL5 ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,Internal medicine ,medicine ,Tumor Cells, Cultured ,Ventricular Dysfunction ,Animals ,Humans ,IL-2 receptor ,Receptor ,Pharmacology ,Inflammation ,Themed Section: Research Paper ,PGG ,Chemistry ,Superoxide ,Angiotensin II ,T cell ,vascular dysfunction ,Hydrolyzable Tannins ,3. Good health ,Mice, Inbred C57BL ,perivascular inflammation ,030104 developmental biology ,Endocrinology ,Oenothera ,Tumor necrosis factor alpha ,030217 neurology & neurosurgery ,Research Paper - Abstract
Background and purpose Hypertension is a multifactorial disease, manifested by vascular dysfunction, increased superoxide production, and perivascular inflammation. In this study, we have hypothesized that 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG) would inhibit vascular inflammation and protect from vascular dysfunction in an experimental model of hypertension. Experimental approach PGG was administered to mice every 2 days at a dose of 10 mg·kg-1 i.p during 14 days of Ang II infusion. It was used at a final concentration of 20 μM for in vitro studies in cultured cells. Key results Ang II administration increased leukocyte and T-cell content in perivascular adipose tissue (pVAT), and administration of PGG significantly decreased total leukocyte and T-cell infiltration in pVAT. This effect was observed in relation to all T-cell subsets. PGG also decreased the content of T-cells bearing CD25, CCR5, and CD44 receptors and the expression of both monocyte chemoattractant protein 1 (CCL2) in aorta and RANTES (CCL5) in pVAT. PGG administration decreased the content of TNF+ and IFN-γ+ CD8 T-cells and IL-17A+ CD4+ and CD3+ CD4- CD8- cells. Importantly, these effects of PGG were associated with improved vascular function and decreased ROS production in the aortas of Ang II-infused animals independently of the BP increase. Mechanistically, PGG (20 μM) directly inhibited CD25 and CCR5 expression in cultured T-cells. It also decreased the content of IFN-γ+ CD8+ and CD3+ CD4- CD8- cells and IL-17A+ CD3+ CD4- CD8- cells. Conclusion and implication PGG may constitute an interesting immunomodulating strategy in the regulation of vascular dysfunction and hypertension. Linked articles This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc.
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- 2019
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53. Noninvasive detection of perivascular inflammation by coronary computed tomography in the CRISP-CT study and its implications for residual cardiovascular risk
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Milind Y. Desai
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0301 basic medicine ,Male ,medicine.medical_specialty ,Time Factors ,Physiology ,Computed Tomography Angiography ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Residual ,Coronary Angiography ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Predictive Value of Tests ,Risk Factors ,Physiology (medical) ,Cause of Death ,Medicine ,Perivascular inflammation ,Humans ,Cause of death ,Computed tomography angiography ,Inflammation ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Coronary computed tomography ,Prognosis ,Coronary Vessels ,030104 developmental biology ,Predictive value of tests ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Risk assessment - Published
- 2018
54. Transient perivascular inflammation of the carotid artery (TIPIC) syndrome.
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Micieli E, Voci D, Mumoli N, Mastroiacovo D, Grigorean A, Obadia M, de Champfleur NM, Naggara O, Carsin B, Amor-Sahli M, Cottier JP, Bensoussan J, Auffray-Calvier E, Varoquaux A, Bonneville F, Sadik JC, Kucher N, Lecler A, and Barco S
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- Cohort Studies, Female, Humans, Inflammation, Middle Aged, Retrospective Studies, Carotid Arteries diagnostic imaging, Carotid Artery, Common
- Abstract
: The Transient Perivascular Inflammation of the Carotid artery (TIPIC) syndrome is presumably a very rare disease characterized by a local transient inflammation of the tissue around the carotid artery. Its pathophysiology remains unknown. We performed an updated study of TIPIC syndrome cases in the setting of a multinational collaborative study. Background : The Transient Perivascular Inflammation of the Carotid artery (TIPIC) syndrome is presumably a very rare disease characterized by a local transient inflammation of the tissue around the carotid artery. Its pathophysiology remains unknown. We performed an updated study of TIPIC syndrome cases in the setting of a multinational collaborative study. Methods : This study was conducted as an observational multinational retrospective individual patient level cohort study. Information from all known cases diagnosed with TIPIC syndrome in the literature (2005-2020) was collected after a semi-structured literature search of PubMed and Web of Science. We also collected unpublished information of patients from French, Swiss, and Italian vascular medicine or radiology departments. Results : A total of 72 patients were included and served for data analysis: 42 (58.3%) were women; the mean age was 47.9 (SD=11.4) years. Symptoms were unilateral in 92% of patients and 81.4% required pain killers. At baseline, irrespective of the imaging method used, the median thickness of the carotid lesions was 5 (Q1-Q3: 4-7; range: 2-11) mm and the median length of the lesion was 20 (Q1-Q3: 10-30; range: 3-50) mm. We found a positive linear correlation between thickness and length. At follow-up, the thickness of the carotid lesions decreased to a median of 2 (Q1-Q3: 1-3; range: 0-6) mm; the length decreased to a median 10 (Q1-Q3: 5-15; range: 0-41) mm. A linear correlation between baseline and follow-up values was observed for both thickness and length measurements. Symptoms disappeared after a median of 14 (Q1-Q3: 10-15) days. Thirteen patients experienced a recurrence after a median follow-up of 6 (Q1-Q3: 2-12) months. Conclusions : The present analysis elucidates clinical and sonographic characteristics of TIPIC syndrome, indicating the benign nature of this condition. A future international registry will study the long-term course of the disease.
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- 2022
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55. Multimodal imaging features of transient perivascular inflammation of the carotid artery (TIPIC) syndrome in a patient with Covid-19.
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Venetis E, Konopnicki D, and Jissendi Tchofo P
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We report the case of a 38-year-old man with transient perivascular inflammation of the carotid artery syndrome that occurred in the course of covid-19. We describe for the first-time multimodal imaging features of the perivascular changes surrounding the carotid artery, and long-term follow-up by ultrasound. The imaging features observed on ultrasound, angiography-CT, MRI and FDG-Pet scan support the hypothesis of the inflammatory nature of the perivascular tissue thickening. The ultrasound follow-up confirmed the spontaneous resolution of the lesion, leaving on site some residual changes as sequelae. The good knowledge of the imaging features reported herein helps to recognize this entity in patients with covid-19., (© 2021 The Authors.)
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- 2022
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56. Chronic Daily House Dust Mite Exposure in Mice is an Effective Model to Quantify the Effect of Pharmacologic Agents on Discrete Stages of Artery Remodeling in Pulmonary Hypertension.
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Steffes LC and Kumar ME
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Pulmonary hypertension (PH) is a heterogenous and incurable disease marked by varying degrees of pulmonary vascular remodeling. This vascular remodeling, which includes thickening of the smooth muscle layer (an early finding) and formation of occlusive neointimal lesions (a late finding) in the pulmonary arteries, is a major driver of morbidity and mortality in PH. Available PH therapies consist of vasodilators that do not specifically target lesion formation or expansion and neither prevent progression nor reverse disease. This paucity of curative treatments highlights the need for new drug discovery targeting crucial steps of artery remodeling in PH. The cell dynamics and molecular signals driving neointimal lesion formation have been difficult to elucidate as classic mouse models of PH do not develop neointima. Here, we detail the methods to generate a robust and non-genetic mouse model of PH with medial thickening and neointimal lesion formation in the pulmonary arteries, through chronic exposure to an inflammatory stimulus-house dust mite (HDM). This model rapidly generates human-like pulmonary arterial lesions following a reproducible time course, allowing scrutiny of the cellular and molecular mechanisms controlling each stage of artery remodeling. Further, we outline optimal tissue handling, sectioning, and staining methodologies for detailed quantitative analysis of artery medial thickening and neointimal lesion formation and expansion. Finally, we present a method for staged pharmacologic intervention to identify molecules and pathways required at each step of the pulmonary arterial remodeling process. The advantages of this mouse model of PH over currently available animal models are five-fold. (i) It allows the use of the full range of genetic and single cell tools available in mice to manipulate and study the process of vascular remodeling seen in human disease, including the formation of neointimal lesions in a controlled and cell specific manner. (ii) The vascular lesions develop in a stereotyped manner with predictable timing, allowing for pharmacologic manipulation at discrete stages of vessel remodeling. (iii) It is rapid, with development of PH and vascular remodeling in a timeframe of two to eight weeks. (iv) It uses simple techniques and requires neither surgery, unusual equipment, or extensive personnel training. (v) The staining and quantitation methodologies we present are a significant improvement over those currently in use in the field. We hope that dissemination of this model and the associated detailed methods will speed up the development of novel and more effective PH therapeutics. Graphic abstract: Chronic perivascular inflammation induces medial thickening and neointima formation in pulmonary arteries, following a stereotyped time course, and allowing staged pharmacologic intervention during specific remodeling events, as well as quantitative assessment of vascular changes., Competing Interests: Competing interestsNone of the authors have financial or non-financial competing interests., (Copyright © 2022 The Authors; exclusive licensee Bio-protocol LLC.)
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- 2022
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57. Use of a new mixture for embolization of intracranial vascular malformations.
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Lylyk, P., Viñuela, F., Vinters, H., Dion, J., Bentson, J., Duckwiler, G., and Lin, T.
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The internal carotid artery system in swine has a special anatomic configuration similar to a brain 'arterial-arterial malformation'. The internal carotid artery breaks up into a multitude of fine channels (rete mirabile) situated at the base of the skull on the side of the hypophysis. This anatomic arterial model was used to analyze acute and chronic angiographic and histological changes after occlusion of the rete mirabile with I) avitene, II) avitene, and 50% ethanol, III) avitene, 30% ethanol and Polyvinyl alcohol, IV) avitene 50% ethanol and Polyvinyl alcohol, V) IBCA and VI) silk. Histopathological changes observed in the rete mirabile six weeks following occlusion demonstrated that a mixture of avitene, 30% ethanol and Polyvinyl alcohol and IBCA produced the best anatomic results. Embolization with avitene, PVA and ethanol induced a more bland histological reaction than the one observed with IBCA. Preliminary clinical experience with this mixture is reassuring in those cases in which the AVM was surgically resected. The partially thrombosed AVM was easily depressed and compressed by the neurosurgeon allowing for satisfactory hemostasis in and around the nidus of the AVM. [ABSTRACT FROM AUTHOR]
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- 1990
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58. Atypical case of perimesencephalic subarachnoid hemorrhage
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Shino Magaki, Harry V. Vinters, Reza Jahan, Konark Malhotra, Maria Inmaculada Cobos Sillero, David S Liebeskind, and Robert D. Brown
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Pathology ,medicine.medical_specialty ,business.industry ,Cistern ,General Medicine ,medicine.disease ,nervous system diseases ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Neuroimaging ,Etiology ,Medicine ,Perivascular inflammation ,Venous leakage ,cardiovascular diseases ,030212 general & internal medicine ,Neurology (clinical) ,Cerebral amyloid angiopathy ,business ,Subcortical lesions ,Perimesencephalic subarachnoid hemorrhage ,030217 neurology & neurosurgery - Abstract
Perimesencephalic subarachnoid hemorrhage (PM-SAH) refers to intracranial hemorrhage located in the perimesencephalic cistern. The etiology remains mainly unclear, although venous leakage or rupture has been postulated. We report an interesting case of a 57-year-old healthy man who presented initially with PM-SAH with worsening of subcortical lesions on follow-up neuroimaging. Histopathological examination demonstrated cerebral amyloid angiopathy with perivascular inflammation.
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- 2016
59. Abstract P338: Aging and Inhibition of Nox1/4 Modulate Perivascular Inflammation in Spontaneous Hypertension
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Joanna Maciag, Mateusz Siedlinski, Tomasz Mikolajczyk, Tomasz J. Guzik, and Ryszard Nosalski
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Pathology ,medicine.medical_specialty ,Blood pressure ,business.industry ,NOX1 ,Internal Medicine ,medicine ,Perivascular inflammation ,Inflammation ,medicine.symptom ,business ,medicine.disease_cause ,Oxidative stress - Abstract
Introduction: Hypertension is associated with enhanced oxidative stress and perivascular inflammation. Although, that aging and oxidative stress are major factors in the development of hypertension their effect on perivascular inflammation remains unclear. Methods: Using flow cytometry we studied leukocytes infiltrating perivascular adipose tissue (PVAT) in 1-, 3-, 6- and 12-month-old SHR (Spontaneously Hypertensive Rats) and normotensive WKY (Wistar-Kyoto) rats. Additionally, 1-month-old rats were treated with GKT137831 (60mg/kg) or ML171 (NOX1/4 and NOX1 inhibitor, respectively) for 4 weeks. Blood pressure (PB) was measured by the tail cuff. Results: Aging in SHRs was associated with elevation of BP (139±4 vs 180±4 vs 202±2 vs 208±2 mmHg; 1 vs 3 vs 6 vs 12-month-old, respectively) when this effect was not seen in WKY rats. While the total number of leukocytes infiltrating PVAT were comparable between 1-month-old WKY and SHR (p=0.8) aging escalated their numbers only in SHRs (2096±164 vs 1994±296 vs 2311±470 vs 3255±408 cell/mg; p int int int int Conclusions: Aging in spontaneous hypertension is associated with elevation of BP and aggravation of perivascular inflammation which are hastened after NOX1/4 inhibitor treatment.
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- 2018
60. Carotidynia Alias Transient Perivascular Inflammation of the Carotid Artery (TIPIC Syndrome)
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Bruno Coulier, Stephane Van den Broeck, and Geoffrey C. Colin
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lcsh:Medical physics. Medical radiology. Nuclear medicine ,Pathology ,medicine.medical_specialty ,Images in Clinical Radiology ,Carotidynia ,business.industry ,lcsh:R895-920 ,Carotid arteries ,medicine.disease ,030218 nuclear medicine & medical imaging ,TIPIC Syndrome ,03 medical and health sciences ,Doppler ultrasonography ,0302 clinical medicine ,MRI ,Contrast-enhanced ultrasound ,Medicine ,Perivascular inflammation ,Radiology, Nuclear Medicine and imaging ,business ,030217 neurology & neurosurgery - Published
- 2018
61. Lesions in the lungs of fatal corona virus disease Covid-19.
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Englisch, Colya N., Tschernig, Thomas, Flockerzi, Fidelis, Meier, Carola, and Bohle, Rainer M.
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VIRUS diseases ,CORONAVIRUSES ,COVID-19 ,SARS-CoV-2 ,LUNGS ,GLYCOCALYX - Abstract
The corona virus outbreak in Wuhan, China, at the end of 2019 has rapidly evolved into a pandemic which is still virulent in many countries. An infection with SARS-CoV-2 can lead to corona virus disease (Covid-19). This paper presents an overview of the knowledge gained so far with regard to histopathological lung lesions in fatal courses of Covid-19. The main findings were diffuse alveolar damage and micro-angiopathies. These included the development of hyaline membranes, thrombi, endothelial inflammation, haemorrhages and angiogenesis. Overall, the vessel lesions seemed to be more lethal than the diffuse alveolar damage. There was obvious hyperreactivity and hyperinflammation of the cellular immune system. An expanded T-cell memory may explain the increased risk of a severe course in the elderly. [ABSTRACT FROM AUTHOR]
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- 2021
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62. Using proteomic and genomic methods to understand JDM
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Rie Karasawa and James N. Jarvis
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Proteomics ,Transcription, Genetic ,Gene Expression Profiling ,Immunology ,Endothelial Cells ,Genomics ,General Medicine ,Disease ,Biology ,medicine.disease ,Bioinformatics ,Dermatomyositis ,Gene expression profiling ,Immune pathogenesis ,medicine ,Humans ,Immunology and Allergy ,Perivascular inflammation ,Biomarkers ,Juvenile dermatomyositis ,Autoantibodies - Abstract
Juvenile dermatomyositis is a complex illness characterized by vascular/perivascular inflammation, primarily in the skin and muscles. In this review, we discuss how proteomic and genomic technologies have expanded our understanding of the immune pathogenesis of this disease. We will also discuss further directions that the field may take to use existing and developing technologies to further our understanding of this often-perplexing disease.
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- 2015
63. Nox1/4 inhibition exacerbates age dependent perivascular inflammation and fibrosis in a model of spontaneous hypertension.
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Nosalski, R., Mikolajczyk, T., Siedlinski, M., Saju, B., Koziol, J., Maffia, P., and Guzik, T.J.
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INFLAMMATION , *BLOOD pressure , *KILLER cells , *NADPH oxidase , *HYPERTENSION , *AORTA , *ACTIVE aging - Abstract
Hypertension is associated with oxidative stress and perivascular inflammation, critical contributors to perivascular fibrosis and accelerated vascular ageing. Oxidative stress can promote vascular inflammation, creating options for potential use of NADPH oxidase inhibitors in pharmacological targeting of perivascular inflammation and its consequences. Accordingly, we characterized age-related changes in oxidative stress and immune cell infiltration in normotensive (WKY) and spontaneously hypertensive rats (SHRs). Subsequently, we used pharmacological inhibitors of Nox1 (ML171) and Nox1/Nox4 (GKT137831; 60 mg/kg), to modulate NADPH oxidase activity at the early stage of spontaneous hypertension and investigated their effects on perivascular inflammation and fibrosis. Ageing was associated with a progressive increase of blood pressure as well as an elevation of the total number of leukocytes, macrophages and NK cells infiltrating perivascular adipose tissue (PVAT) in SHRs but not in WKY. At 1 month of age, when blood pressure was not yet different, only perivascular NK cells were significantly higher in SHR. Spontaneous hypertension was also accompanied by the higher perivascular T cell accumulation, although this increase was age independent. Aortic Nox1 and Nox2 mRNA expression increased with age only in SHR but not in WKY, while age-related increase of Nox4 mRNA in the vessels has been observed in both groups, it was more pronounced in SHRs. At early stage of hypertension (3-months) the most pronounced differences were observed in Nox1 and Nox4. Surprisingly, GKT137831, dual inhibitor of Nox1/4, therapy increased both blood pressure and perivascular macrophage infiltration. Mechanistically, this was linked to increased expression of proinflammatory chemokines expression (CCL2 and CCL5) in PVAT. This inflammatory response translated to increased perivascular fibrosis. This effect was likely Nox4 dependent as the Nox1 inhibitor ML171 did not affect the development of spontaneous hypertension, perivascular macrophage accumulation, chemokine expression nor adventitial collagen deposition. In summary, spontaneous hypertension promotes ageing-associated perivascular inflammation which is exacerbated by Nox4 but not Nox1 pharmacological inhibition. [ABSTRACT FROM AUTHOR]
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- 2020
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64. Abstract 060: Role of Mir-214 in the Regulation of Perivascular Fibrosis in Angiotensin II Induced Hypertension
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Aurelie Nguyen Dinh Cat, Dominik Skiba, Laura Denby, Mateusz Siedlinski, Tomasz J. Guzik, Eilidh McGinnigle, Andy Baker, and Ryszard Nosalski
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business.industry ,Inflammation ,medicine.disease ,Angiotensin II ,Novel gene ,Fibrosis ,microRNA ,Internal Medicine ,Cancer research ,Perivascular inflammation ,Medicine ,medicine.symptom ,business ,miR-214 ,Perivascular fibrosis - Abstract
Objective: Hypertension (HT) is associated with perivascular inflammation and increased vascular fibrosis. MicroRNAs (miR) are a novel gene expression regulation mechanism and play a pivotal role in a range of pathological processes. The role and mechanism of miR214 in vascular fibrosis is unknown. Methods: 3-month-old C57BL/6, miR214KO and wild-type littermates were treated with angiotensin II (AngII, 490ng/kg/min; n=6-10) or control buffer for 14 days. PVATs from C57BL/6 animals were analysed using TaqMan_Rodent_microRNA_Arrays. Histological studies, wire myography, lucigenin-enhanced luminometry and cytometrical analysis was conducted, followed by statistical analysis with ANOVA or t-test. Data are expressed as a mean±SEM. Results: Out of 381 miRs, 16 were significantly overexpressed in C57BL/6 AngII animals, with only miR214 showing 8-fold induction (p Conclusions: MiR-214 plays a major role in modulation of aortic fibrosis, vascular function, oxidative stress and perivascular inflammation.
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- 2017
65. Spatiotemporal evolution of venous narrowing in acute MS lesions
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Wolfgang Brueck, Anne Ebert, Philipp Eisele, Kristina Szabo, Achim Gass, and Michael Platten
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Mean diameter ,Contrast enhancement ,business.industry ,Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Text mining ,Neurology ,Perivascular inflammation ,Medicine ,Deoxygenated Hemoglobin ,Neurology (clinical) ,Nuclear medicine ,business ,Vein ,030217 neurology & neurosurgery - Abstract
ObjectiveTo investigate the spatiotemporal evolution of venous narrowing in newly developing MS lesions in a longitudinal MRI study including susceptibility-weighted images (SWIs).MethodsWe retrospectively investigated serial MR examinations of 18 patients with MS acquired on a 3T MRI system including SWI for acute contrast-enhancing lesions with at least 1 MRI examination before contrast enhancement. The mean diameter of veins at the time point of contrast enhancement was compared with the mean diameter of veins before and after contrast enhancement.ResultsA total of 40 acute contrast-enhancing lesions with a corresponding intralesional central vein were included in the study. The mean diameter of intralesional veins at the time of contrast enhancement (0.80 ± 0.12 mm) was smaller than that at before (1.16 ± 0.19 mm) and after contrast enhancement (1.07 ± 0.15 mm; p < 0.001 for all comparisons).ConclusionsOur findings contribute to the increasing database of plaque development and evolution. The smaller diameter of intralesional veins on SWI at the time of blood-brain barrier breakdown may reflect morphologic changes because of perivascular inflammation and/or decreased levels of deoxygenated hemoglobin.
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- 2017
66. Perivascular carotid inflammation: an unusual case of carotidynia.
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Azar, Lama and Fischer, Harry
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CASE studies , *DRUG therapy , *DUCTAL carcinoma , *BREAST tumors , *CAROTID artery diseases - Abstract
A 59-year-old woman was admitted to the hospital with a fever and rigors for 2 days. She was on chemotherapy (docetaxel, carboplatin, and trastuzumab) for her stage II invasive ductal carcinoma of the breast. Her physical exam was unremarkable except for the fever. The white blood cells were 21,200/mm with 92% of neutrophils. ESR was 106 mm/h. An extensive infectious workup was negative. On day 6, while still febrile, the patient complained of a left-sided neck pain. She exhibited tenderness over the left carotid artery. A CT scan of the neck without intravenous contrast showed perivascular inflammation of the left common carotid artery, without evidence of a collection, arterial thrombosis, aneurysm, or dissection. The etiology of this finding was possibly chemotherapy related. It dramatically responded to oral prednisone. A repeat CT scan of the neck with IV contrast 2 weeks later showed a remarkable improvement. Drug reactions can simulate systemic inflammatory diseases and should always be considered in the diagnosing process. [ABSTRACT FROM AUTHOR]
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- 2012
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67. Perivascular inflammation in coronary spasm
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Gregory B. Lim
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Pathology ,medicine.medical_specialty ,business.industry ,Adipose tissue ,Inflammation ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Coronary vasospasm ,Medicine ,Perivascular inflammation ,030212 general & internal medicine ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
68. Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats.
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Ishikawa T, Abe K, Takana-Ishikawa M, Yoshida K, Watanabe T, Imakiire S, Hosokawa K, Hirano M, Hirano K, and Tsutsui H
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- Animals, Antirheumatic Agents pharmacology, Disease Models, Animal, Hypertension, Pulmonary metabolism, Hypertension, Pulmonary physiopathology, Male, Pulmonary Artery physiopathology, Rats, Rats, Sprague-Dawley, Vascular Remodeling drug effects, Chloroquine pharmacology, Hypertension, Pulmonary drug therapy, Monocrotaline pharmacology, Pulmonary Artery drug effects, Toll-Like Receptor 9 antagonists & inhibitors
- Abstract
Background Recent accumulating evidence suggests that toll-like receptor 9 (TLR9) is involved in the pathogenesis of cardiovascular diseases. However, its role in pulmonary hypertension remains uncertain. We hypothesized that TLR9 is involved in the development of pulmonary hypertension. Methods and Results A rat model of monocrotaline-induced pulmonary hypertension was used to investigate the effects of TLR9 on hemodynamic parameters, vascular remodeling, and survival. Monocrotaline-exposed rats significantly showed increases in plasma levels of mitochondrial DNA markers, which are recognized by TLR9, TLR9 activation in the lung, and interleukin-6 mRNA level in the lung on day 14 after monocrotaline injection. Meanwhile, monocrotaline-exposed rats showed elevated right ventricular systolic pressure, total pulmonary vascular resistance index and vascular remodeling, together with macrophage accumulation on day 21. In the preventive protocol, administration (days -3 to 21 after monocrotaline injection) of selective (E6446) or nonselective TLR9 inhibitor (chloroquine) significantly ameliorated the elevations of right ventricular systolic pressure and total pulmonary vascular resistance index as well as vascular remodeling and macrophage accumulation on day 21. These inhibitors also significantly reduced NF-κB activation and interleukin-6 mRNA levels to a similar extent. In the short-term reversal protocol, E646 treatment (days 14-17 after monocrotaline injection) almost normalized NF-κB activation and interleukin-6 mRNA level, and reduced macrophage accumulation. In the prolonged reversal protocol, E6446 treatment (days 14-24 after monocrotaline injection) reversed total pulmonary vascular resistance index and vascular remodeling, and improved survival in monocrotaline-exposed rats. Conclusions TLR9 is involved in the development of pulmonary hypertension concomitant via activation of the NF-κB‒IL-6 pathway. Inhibition of TLR9 may be a novel therapeutic strategy for pulmonary hypertension.
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- 2021
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69. Cerebral Amyloid Angiopathy–related Inflammation Presenting With Rapidly Progressive Dementia, Responsive to IVIg
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Jasmyn De Leon, Alvin R.F. Cenina, Nagaendran Kandiah, Chin Fong Wong, and Kay Yaw Tay
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Pathology ,medicine.medical_specialty ,Time Factors ,Amyloid ,Inflammation ,mental disorders ,Humans ,Immunologic Factors ,Medicine ,Perivascular inflammation ,In patient ,Dementia diagnosis ,cardiovascular diseases ,Aged ,Rapidly progressive dementia ,business.industry ,Immunoglobulins, Intravenous ,nutritional and metabolic diseases ,medicine.disease ,Cerebral Amyloid Angiopathy ,Psychiatry and Mental health ,Clinical Psychology ,Disease Progression ,Dementia ,Female ,Cerebral amyloid angiopathy ,Geriatrics and Gerontology ,Headaches ,medicine.symptom ,business ,Gerontology - Abstract
Cerebral amyloid angiopathy–related inflammation (CAA-I) was first described in 2004 with 7 cases of perivascular inflammation in patients with CAA.1 So far
- Published
- 2015
70. Echocardiographically measured epicardial fat predicts restenosis after coronary stenting
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Byoung-Joo Choi, Joon-Han Shin, Gyo-Seung Hwang, Myeong-Ho Yoon, Seung-Jea Tahk, Jin-Sun Park, and So-Yeon Choi
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Kaplan-Meier Estimate ,Coronary Restenosis ,Percutaneous Coronary Intervention ,Postoperative Complications ,Restenosis ,Smooth muscle ,Internal medicine ,medicine ,Humans ,Perivascular inflammation ,Adiposity ,Aged ,business.industry ,Coronary stenting ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,Epicardial fat ,Logistic Models ,Adipose Tissue ,Echocardiography ,Cardiology ,Epicardial adipose tissue ,Female ,Stents ,Cardiology and Cardiovascular Medicine ,business - Abstract
Epicardial adipose tissue (EAT), deposited around subepicardial coronary vessels, may contribute directly to perivascular inflammation and smooth muscle cell proliferation. This study assessed the relationship between EAT and in-stent restenosis.Four hundred and seven patients had received successful coronary intervention. EAT thickness was measured by echocardiography. Angiographic follow-up was obtained between 6 months and 2 years. Restenosis was defined as target lesion revascularization (TLR). EAT thickness of patients was compared by TLR controlling for additional well-known predictors of restenosis. The TLR-free survival analysis according to EAT thickness was estimated using the Kaplan-Meier method and the differences between groups were assessed by the log-rank test.Median EAT thickness was significantly increased in patients undergoing TLR compared with those without restenosis (3.7 vs. 3.0 mm, p = 0.001). EAT thickness was one of the independent factors associated with restenosis (Odds ratio = 1.19, 95% confidence interval = 1.01-1.33, p = 0.007). The TLR-free survival of patients with thick EAT was significantly worse than patients with thin EAT (log-rank p = 0.001).EAT thickness is related with restenosis and may provide additional information for future restenosis.
- Published
- 2013
71. Abstract 596: Increased Migration of Neutrophils Across Endothelial Cells from Patients with Pulmonary Arterial Hypertension is Related to Reduced Platelet Endothelial Cell Adhesion Molecule -1 and is Prevented by the Neutrophil Elastase Inhibitor Elafin
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Marlene Rabinovitch, Mingxia Gu, Lingli Wang, Shalina Taylor, Kazuya Miyagawa, Jan K. Hennigs, Jan-Renier A. J. Moonen, and Silin Sa
- Subjects
biology ,business.industry ,Vasodilation ,medicine.disease ,Neutrophil elastase ,cardiovascular system ,Cancer research ,biology.protein ,medicine ,Perivascular inflammation ,Platelet endothelial cell adhesion molecule-1 ,Cardiology and Cardiovascular Medicine ,business ,Elafin ,Progressive disease - Abstract
Pulmonary arterial hypertension (PAH) is a devastating progressive disease associated with a high mortality despite current vasodilator therapies. Perivascular inflammation and high levels of neutrophil elastase are thought to play a pivotal role in the adverse vascular remodeling of small pulmonary arteries that causes PAH. Despite this, the function of neutrophils and in particular, their interaction with the pulmonary arterial endothelium has not been studied in PAH. We hypothesized that neutrophil functions such as adhesion to a substratum or to endothelial cells and transmigration across a substratum or trans-endothelial migration (TEM) are abnormal in PAH on the basis of dysfunction of both cell types. Using a neutrophil like cell line dHL-60 and isolated human neutrophils from donors and PAH patients, we demonstrated no significant difference in adhesion to PAH vs. control PAECs when stimulated with TNF-α (100μg/mL). However, TEM of both IL-8 (100ng/ml) and fMLP (100nM) stimulated dHL-60 cells and donor neutrophils was enhanced in PAH vs. control PAECs (p
- Published
- 2016
72. Association between perivascular inflammation and downstream myocardial perfusion in patients with suspected coronary artery disease.
- Author
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Nomura CH, Assuncao-Jr AN, Guimarães PO, Liberato G, Morais TC, Fahel MG, Giorgi MCP, Meneghetti JC, Parga JR, Dantas-Jr RN, and Cerri GG
- Subjects
- Aged, Computed Tomography Angiography, Coronary Angiography, Humans, Inflammation diagnostic imaging, Middle Aged, Perfusion, Coronary Artery Disease diagnostic imaging
- Abstract
Aims: To investigate the association between pericoronary adipose tissue (PCAT) computed tomography (CT) attenuation derived from coronary computed tomography angiography (CTA) and coronary flow reserve (CFR) by positron emission tomography (PET) in patients with suspected coronary artery disease (CAD)., Methods and Results: PCAT CT attenuation was measured in proximal segments of all major epicardial coronary vessels of 105 patients with suspected CAD. We evaluated the relationship between PCAT CT attenuation and other quantitative/qualitative CT-derived anatomic parameters with CFR by PET. Overall, the mean age was 60 ± 12 years and 93% had intermediate pre-test probability of obstructive CAD. Obstructive CAD (≥50% stenosis) was detected in 37 (35.2%) patients and impaired CFR (<2.0) in 32 (30.5%) patients. On a per-vessel analysis (315 vessels), obstructive CAD, non-calcified plaque volume, and PCAT CT attenuation were independently associated with CFR. In patients with coronary calcium score (CCS) <100, those with high-PCAT CT attenuation presented significantly lower CFR values than those with low-PCAT CT attenuation (2.47 ± 0.95 vs. 3.13 ± 0.89, P = 0.003). Among those without obstructive CAD, CFR was significantly lower in patients with high-PCAT CT attenuation (2.51 ± 0.95 vs. 3.02 ± 0.84, P = 0.021)., Conclusion: Coronary perivascular inflammation by CTA was independently associated with downstream myocardial perfusion by PET. In patients with low CCS or without obstructive CAD, CFR was lower in the presence of higher perivascular inflammation. PCAT CT attenuation might help identifying myocardial ischaemia particularly among patients who are traditionally considered non-high risk for future cardiovascular events., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2020
- Full Text
- View/download PDF
73. Clinical Analysis of Lobular Keloid after Ear Piercing
- Author
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So Min Hwang, Sung Chul Chu, Hook Sun, Min Kyu Hwang, Jong Seo Lee, Min Wook Kim, and Hyung Do Kim
- Subjects
medicine.medical_specialty ,Hypertrophic inflammation ,Biopsy ,Treatment outcome ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Keloid ,Ear piercing ,medicine ,Perivascular inflammation ,030223 otorhinolaryngology ,Surgical treatment ,skin and connective tissue diseases ,Inflammatory ,Retrospective review ,Clinical pathology ,business.industry ,medicine.disease ,Dermatology ,Surgery ,body regions ,Otorhinolaryngology ,Original Article ,business - Abstract
Background Lobular keloid appears to be a consequence of hypertrophic inflammation secondary to ear piercings performed under unsterile conditions. We wish to understand the pathogenesis of lobular keloids and report operative outcomes with a literature review. Methods A retrospective review identified 40 cases of lobular keloids between January, 2005 and December, 2010. Patient records were reviewed for preclinical factors such as presence of inflammation after ear piercing prior to keloid development, surgical management, and histopathologic correlation to recurrence. Results The operation had been performed by surgical core extirpation or simple excision, postoperative lobular compression, and scar ointments. Perivascular infiltration was noted in intra- and extra-keloid tissue in 70% of patients. The postoperative recurrence rate was 10%, and most of the patients satisfied with treatment outcomes. Conclusion Histological perivascular inflammation is a prominent feature of lobular keloids. Proper surgical treatment, adjuvant treatments, and persistent follow-up observation were sufficient in maintaining a relatively low rates of recurrence.
- Published
- 2015
74. Infection and Involution of Mouse Thymus by MHV-4
- Author
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Knobler, R. L., Oldstone, M. B. A., Lai, Michael M. C., editor, and Stohlman, Stephen A., editor
- Published
- 1987
- Full Text
- View/download PDF
75. Clinico pathological study of adult dermatomyositis: Importance of muscle histology in the diagnosis
- Author
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Sundaram Challa, Liza Rajashekhar, Megha S Uppin, Meena A Kannan, and Sudhir Babu Karri
- Subjects
Pathology ,medicine.medical_specialty ,Muscle biopsy ,Proximal muscle weakness ,medicine.diagnostic_test ,Neck muscle weakness ,business.industry ,Dermatomyositis ,medicine.disease ,Rash ,Adult dermatomyositis ,lcsh:RC346-429 ,perivascular inflammation ,Atrophy ,Skin biopsy ,medicine ,Original Article ,Neurology (clinical) ,medicine.symptom ,business ,lcsh:Neurology. Diseases of the nervous system ,perifascicular atrophy - Abstract
Aims: To study the histological features on muscle biopsy and correlate them with clinical features, other laboratory data in adult patients to make a diagnosis of dermatomyositis (DM), applying the European Neuromuscular center (ENMC) criteria. Materials and Methods: Adult patients who fulfilled clinical, laboratory, and muscle biopsy findings according to ENMC criteria for DM during the period 2010-2013 were included in the study. Cryostat sections of muscle biopsy were reviewed with emphasis on Perifascicular atrophy (PFA), perivascular/endomysial inflammation. Muscular dystrophies and metabolic myopathies were excluded by appropriate immunohistochemistry and special stains. Results: The diagnosis of adult DM was made in 45 patients out of 170 clinically suspected idiopathic inflammatory myopathies. These included 33 definite, 4 probable, 7 possible sine dermatitis, and 1 amyopathic DM. All patients with definite DM had typical rash and proximal muscle weakness and muscle biopsy showed PFA with or without inflammation. Thirteen patients had quadriparesis, neck muscle weakness, dysphagia/dysphonia at presentation. Patients with probable DM had rash and showed perivascular/endomysial inflammation with no PFA. Possible DM sine dermatitis showed PFA with perivascular/endomysial infiltrates. One patient of amyopathic DM had typical heliotrope rash and characteristic skin biopsy. Conclusions: Histological features are important for the diagnosis of DM. Relying on PFA for diagnosis of definite DM underestimates the true frequency of DM.
- Published
- 2014
76. How do we measure pathology in PAH (lung and RV) and what does it tell us about the disease
- Author
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Rubin M. Tuder
- Subjects
Pharmacology ,Pathology ,medicine.medical_specialty ,Lung ,business.industry ,Heart Ventricles ,Hypertension, Pulmonary ,Ventricular Dysfunction, Right ,Disease ,medicine.disease ,Pulmonary hypertension ,medicine.anatomical_structure ,Human disease ,Ventricle ,Drug Discovery ,medicine ,Perivascular inflammation ,Animals ,Humans ,Pulmonary pathology ,Ventricular remodeling ,business - Abstract
The current understanding of the pathology that underlies pulmonary vascular and right ventricular remodeling in pulmonary hypertension is discussed. Although recent studies underscored the importance of intima and media remodeling and, for the first time, the relevance of perivascular inflammation, much is needed to move the field forward. Reassessment of distribution and extension of the different vascular lesions requires state-of-the-art stereological tools, allied to three-dimensional casting and integration with data concerning cellular and molecular pathobiological processes. This integrated approach is ever more pressing in the right ventricle, because our understanding of key structural alterations of the failing right ventricle in pulmonary hypertension is lacking. This enterprise will enable better translation of pathogenetic processes to the human disease and provide key data to guide diagnostic and prognostic imaging approaches.
- Published
- 2014
77. Perivascular inflammation drives sympathetic hyperinnervation and hypertension in obesity (682.1)
- Author
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Rebecca E. Haddock, Caryl E. Hill, Klaus I. Matthaei, and Grant R Drummond
- Subjects
medicine.medical_specialty ,Pathology ,business.industry ,Sympathetic nerve ,medicine.disease ,Biochemistry ,Obesity ,Endocrinology ,Blood pressure ,Internal medicine ,Genetics ,Medicine ,Perivascular inflammation ,sense organs ,business ,Molecular Biology ,Biotechnology - Abstract
Hypertension in obesity occurs as a result of abnormal increases in sympathetic nerve density over arteries controlling blood pressure; the causative factors underlying these changes are unknown. H...
- Published
- 2014
78. TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis
- Author
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Lesley Probert, George Kassiotis, Manolis Pasparakis, and George Kollias
- Subjects
Central Nervous System ,Male ,Encephalomyelitis, Autoimmune, Experimental ,Primary demyelination ,Immunology ,Congenic ,Major histocompatibility complex ,Mice ,immune system diseases ,medicine ,Animals ,Immunology and Allergy ,Perivascular inflammation ,Mice, Knockout ,biology ,Tumor Necrosis Factor-alpha ,Incidence ,Experimental autoimmune encephalomyelitis ,Haplotype ,H-2 Antigens ,Myelin Basic Protein ,medicine.disease ,nervous system diseases ,Myelin basic protein ,Mice, Inbred C57BL ,biology.protein ,Female ,Tumor necrosis factor alpha ,Disease Susceptibility ,Demyelinating Diseases - Abstract
Experimental autoimmune encephalomyelitis (EAE) induction in TNF gene-targeted mice has resulted in conflicting reports in part due to the strong association of TNF with the MHC locus. To define the participation of TNF in EAE development, we back-crossed TNF-deficient mice (H-2b) into the SJL/J strain and directly compared them to H-2b congenic SJL or inbred SJL/J mice. Induction of EAE with myelin basic protein (MBP) revealed that H-2b congenic SJL mice are fully susceptible, indicating that the H-2b haplotype does not affect disease susceptibility. Using H-2b congenic SJL mice we show here that TNF deficiency modifies the normal course of EAE by considerably delaying the onset for approximately 5 days, suggesting that TNF is required for the normal initiation of MBP-induced EAE. However, TNF-deficient mice eventually developed severe EAE with perivascular inflammation and primary demyelination similar to wild-type controls, indicating that TNF is not essential during these processes. Taken together, these results indicate that although TNF is not required for the progression of MBP-induced EAE, it contributes positively by advancing the onset of disease.
- Published
- 1999
79. Acute Pulmonary Hypertension Crisis after Adalimumab Reduction in Rheumatoid Vasculitis.
- Author
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Yamasaki G, Okano M, Nakayama K, Jimbo N, Sendo S, Tamada N, Misaki K, Shinkura Y, Yanaka K, Tanaka H, Akashi K, Morinobu A, Yokozaki H, Emoto N, and Hirata KI
- Subjects
- Adalimumab therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Humans, Inflammation, Male, Middle Aged, Adalimumab adverse effects, Arthritis, Rheumatoid drug therapy, Hypertension, Pulmonary etiology, Rheumatoid Vasculitis chemically induced
- Abstract
Rheumatoid vasculitis is a rare etiology for pulmonary hypertension (PH) in patients with connective tissue disease. We encountered a case of acute PH crisis in a case with rheumatoid vasculitis eight months after undergoing adalimumab reduction. Since no repetition of arthralgia occurred after the adalimumab reduction, we decided to not increase the dose of adalimumab. However, hemodynamic collapse thereafter developed and even though steroid pulse therapy was administered, the patient nevertheless died. The autopsy showed clusters of acute and chronic inflammation around the remodeled pulmonary arteries along with micro-thrombi in the vessel lumen. We should consider the possibility of critical worsening of PH as a phenotype of vasculitis related to immunosuppressive therapy reduction.
- Published
- 2019
- Full Text
- View/download PDF
80. A distinctive type of infantile inflammatory myopathy with abnormal myonuclei
- Author
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Stirling Carpenter, George Karpati, and Naganand Sripathi
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Microtubules ,Inflammatory myopathy ,Muscular Diseases ,Adrenal Cortex Hormones ,medicine ,Humans ,Perivascular inflammation ,Muscle, Skeletal ,Myopathy ,Cell Nucleus ,Muscle Weakness ,business.industry ,Infant ,Progressive muscle weakness ,medicine.disease ,Cell nucleus ,medicine.anatomical_structure ,Neurology ,Child, Preschool ,Serum creatine kinase ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Four infants developed progressive muscle weakness after a normal initial postnatal development. All patients had a moderate elevation of serum creatine kinase (CK) activity. Muscle biopsies revealed, in addition to myopathic features, endomysial and perivascular inflammation. Electron microscopy disclosed prominent myonuclear abnormalities. Corticosteroids in 3 patients were moderately beneficial. This appears to be a clinicopathologically distinct form of inflammatory myopathy of infants.
- Published
- 1996
81. Neues in der Pathophysiologie und Therapie von Kopfschmerzen
- Author
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H. C. Diener
- Subjects
Gynecology ,medicine.medical_specialty ,Valproic Acid ,education.field_of_study ,Acute migraine ,business.industry ,Population ,medicine.disease ,Migraine prophylaxis ,Sumatriptan ,Migraine ,medicine ,Reflex ,Perivascular inflammation ,Neurology (clinical) ,education ,business ,Neuroscience ,medicine.drug - Abstract
Migraine is more common than previously reported. Three large epidemiological studies showed that the prevalence of migraine in the general population is 12-14% for women and 5-7% for men. Animal experiments suggest that the headache in migraine might be due to alterations of a trigemino-vascular reflex resulting in vasodilatation, plasma extravasation and perivascular inflammation of dural arteries. In addition to sumatriptan a number of other 5-HT-1D receptor agonists are under investigation and will be available for the treatment of acute migraine attacks in the near future. For the prevention of migraine, valproic acid has been shown to be effective in cases that are refractory to traditional migraine prophylaxis. Neurophysiological data indicate that the central pain threshold may be altered in chronic tension-type headache. Die Migrane ist haufiger als bisher angenommen. Drei grose epidemiologische Studien zeigen, dass die Pravalenz der Migrane bei Frauen zwischen 12-14% und bei Mannern zwischen 5-7% betragt. Fur die Entstehung der Kopfschmerzen bei der Migrane wird ein pathologischer trigemino-vaskularer Reflex verantwortlich gemacht, der zur Vasodilatation, Plasmaextravasation und perivaskularer Entzundung im Bereich von Duraarterien fuhrt. Eine Vielzahl neuer Serotonin (5HT-lD)-Rezeptor-Agonisten werden neben Sumatriptan in den nachsten Jahren Eingang in die Therapie der akuten Migraneattacke finden. Als neues Medikament fur die Migraneprophylaxe hat sich im letzten Jahr die Valproinsaure etabliert. Neue neurophysiologische Untersuchungen zeigen, dass beim chronischen Spannungskopfschmerz eine veranderte zentrale Schmerzschwelle besteht.
- Published
- 1994
82. Septal granulomatous panniculitis: Comparison of the pathology of erythema nodosum migrans (migratory panniculitis) and chronic erythema nodosum
- Author
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W.P. Daniel Su, Richard K. Winkelmann, and Cristiane de Almeida Prestes
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Panniculitis ,Diagnostico diferencial ,Cell Count ,Dermatology ,Giant Cells ,Erythema nodosum migrans ,Erythema Nodosum ,Sex Factors ,Fibrosis ,medicine ,Humans ,Perivascular inflammation ,skin and connective tissue diseases ,Aged ,integumentary system ,business.industry ,Age Factors ,Granulation tissue ,Cell Differentiation ,Chronic erythema ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Giant cell ,Chronic Disease ,Female ,business - Abstract
Fifty-eight cases of septal granulomatous panniculitis were reviewed; 14 cases were diagnosed as erythema nodosum migrans (migratory panniculitis) and 36 as chronic erythema nodosum on the basis of clinical and histopathologic features. Erythema nodosum migrans was characterized by markedly thickened and fibrotic septae, marked capillary proliferation (like granulation tissue), and massive granulomatous reaction (with giant cells) along the borders of the widened septa. Hemorrhage was rare, and phlebitis was not seen. Chronic erythema nodosum showed mild septal change, little fibrosis, and lymphohistiocytic perivascular inflammation with only focal granulomatous formation. Phlebitis and hemorrhage were common. The condition termed erythema nodosum migrans has many of the same clinical features as chronic erythema nodosum, and we think this term is preferable to migratory panniculitis. We believe that there are sufficient clinical and histopathologic features to justify considering erythema nodosum migrans as a unique clinicopathologic entity.
- Published
- 1990
83. Carotidynia: A Rare Diagnosis in Vascular Surgery Practice
- Author
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W.M. Palm, Jaap F. Hamming, and K.E.A. van der Bogt
- Subjects
Medicine(all) ,Neck pain ,medicine.medical_specialty ,Carotidynia ,Carotid dissection ,medicine.diagnostic_test ,business.industry ,Carotid arteries ,Magnetic resonance imaging ,Vascular surgery ,medicine.disease ,Surgery ,medicine ,Perivascular inflammation ,Carotid body tumour ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Carotid artery ,MRI - Abstract
Carotidynia is a rare diagnosis for unilateral neck pain without a clear physical substrate. As such, it may be encountered in surgery practice when analysing carotid artery status in symptomatic patients. Here, a case is presented which outlines the diagnostic process and subsequent treatment of carotidynia. As opposed to vascular causes of unilateral neck pain, carotidynia can be easily treated conservatively. Relief of complaints as well as regression of perivascular inflammation on magnetic resonance imaging can be effectively achieved with the use of non-steroidal anti-inflammatory drugs.
- Published
- 2012
84. Endothelial cell biology, perivascular inflammation, and vasculitis
- Author
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Maria C. Cid
- Subjects
Vasculitis ,Pathology ,medicine.medical_specialty ,Endothelium ,Antibodies, Antineutrophil Cytoplasmic ,Neovascularization ,Cytokines metabolism ,medicine ,Perivascular inflammation ,Humans ,Autoantibodies ,biology ,Neovascularization, Pathologic ,business.industry ,General Medicine ,medicine.disease ,Endothelial stem cell ,medicine.anatomical_structure ,biology.protein ,Cytokines ,Vascular pathology ,Endothelium, Vascular ,Antibody ,medicine.symptom ,business ,Cell Adhesion Molecules - Published
- 2002
85. Clinicopathological Investigation of AVMs Embolized with HEMA-MMA. A New Non-Adhesive Liquid Material
- Author
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Y. Ueno, Y. Nomoto, Akira Tanaka, Hiroshi Aikawa, and Kiyoshi Kazekawa
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Original Articles ,medicine.disease ,Embolic Agent ,medicine.anatomical_structure ,Giant cell ,Scalp ,medicine ,Perivascular inflammation ,Embolization ,Foreign body ,business ,Infiltration (medical) - Abstract
We have recently developed a non-adhesive liquid embolic agent, hydroxyethylmethacrylate methylmethacrylate copolymer (HEMA-MMA), and used it for arteriovenous malformations (AVMs) in the central nervous system. To evaluate the toxicity and usefulness of this agent, we made a clinicopathological study of AVMs that were embolized with it and then excised surgically. This study includes ten cases: nine with pial AVM and one with scalp AVM. In a pathological study, special attention was paid to vascular and perivascular inflammation, angionecrosis, recanalization of the embolized vessels, and foreign body reactions. Inflammation was absent or very mild regardless of the interval between embolization and excision. There was no angionecrosis. Recanalization could be expected to occur in the partially occluded vessel. Foreign body reactions such as infiltration of monocytes or giant cells, and proliferation of fibroblasts or capillaries were also not seen in any case. It was concluded that HEMA-MMA is an excellent embolic material that is easy to handle, less vasotoxic than other agents, and highly his-tocompatible.
- Published
- 2001
86. Histologic evaluation of the long term effects of tretinoin on photodamaged skin
- Author
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Barbara A. Gilchrest, E.G. Thorne, Elise A. Olsen, Jag Bhawan, Laura Lufrano, and B. Schwab
- Subjects
Pathology ,medicine.medical_specialty ,Topical tretinoin ,Photoaging ,Tretinoin ,Dermatology ,Biochemistry ,Melanin ,Double-Blind Method ,Medicine ,Perivascular inflammation ,Humans ,Molecular Biology ,integumentary system ,biology ,business.industry ,Follow up studies ,medicine.disease ,Skin Aging ,Continuous treatment ,Face ,biology.protein ,Epidermis ,business ,Elastin ,medicine.drug ,Follow-Up Studies - Abstract
Sustained improvement with prolonged topical tretinoin for photodamaged skin has been well documented for up to 22 months of continuous treatment. We now report long-term (4 years) histologic effects of topical tretinoin in photodamaged skin of 27 patients, the longest study to date. The observed decreases in dermal elastin content and perivascular inflammation and increase in epidermal mucin in facial biopsies obtained after up to 4 years of treatment may be partly responsible for the continued clinical improvement. Furthermore, the study shows that there are no untoward effects on keratinocytes or melanocytes during long-term use of topical tretinoin.
- Published
- 1996
87. Correlation between the intensity of cytomegalovirus infection and the amount of perivasculitis in aortic allografts
- Author
-
M. Yin, C. A. Bruggeman, Fengling Li, and Gert Grauls
- Subjects
business.industry ,medicine.medical_treatment ,Congenital cytomegalovirus infection ,Immunosuppression ,Total body irradiation ,medicine.disease ,Cytomegalovirus infection ,Immunology ,medicine ,Perivascular inflammation ,business ,Infiltration (medical) ,Infectious virus ,CD8 - Abstract
We previously demonstrated that cytomegalovirus (CMV) infection enhanced perivascular inflammation in rat aortic allografts. In this study, we investigated the relationship between the CMV infection load and the magnitude of perivasculitis (chronic rejection) in aortic transplants. Rats received orthotopic abdominal aortic grafts, different degrees of total body irradiation (TBI) for immunosuppression and CMV inoculation. The spleens of the rats receiving 5 Gy of TBI contained more infectious virus and viral antigens than those of rats receiving 3 Gy of TBI or no TBI. Although the number of inflammatory cells infiltrating the perivascular area was decreased after TBI, CMV infection resulted in increased perivasculitis in rats that received 5 Gy of TBI as compared to non-infected animals. This virus-induced effect was characterized predominantly by an increased T-cell infiltration, including CD4 and CD8 T-cells. It is concluded that an enhanced systemic CMV infection during severe immunosuppressive therapy can accelerate the development of chronic rejection, which seems to be mediated mainly by T-cells.
- Published
- 1996
88. Mechanisms and characteristics of perivascular inflammation in hypertension and early atherosclerosis
- Author
-
Tomasz J. Guzik
- Subjects
Pharmacology ,Pathology ,medicine.medical_specialty ,Physiology ,business.industry ,medicine ,Molecular Medicine ,Perivascular inflammation ,business - Published
- 2012
89. Mechanism of Aggravation of Cardiac Remodeling Induced by Hypertension With Large Pressure Variability - A Role of Perivascular Inflammation
- Author
-
Hisashi Kai, Tsutomu Imaizumi, and Hiroshi Kudo
- Subjects
medicine.medical_specialty ,Mechanism (biology) ,business.industry ,Internal medicine ,medicine ,Cardiology ,Perivascular inflammation ,Cardiology and Cardiovascular Medicine ,business - Published
- 2009
90. Lipopolysaccharide induced inflammation in the perivascular space in lungs
- Author
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Reinhard Pabst, Kyathanahalli S. Janardhan, Thomas Tschernig, and Baljit Singh
- Subjects
Pathology ,medicine.medical_specialty ,Lipopolysaccharide ,Pharmacology toxicology ,Inflammation ,Toxicology ,lcsh:RC963-969 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Medicine ,Perivascular inflammation ,Perivascular space ,030304 developmental biology ,0303 health sciences ,Lung ,business.industry ,Research ,Public Health, Environmental and Occupational Health ,respiratory system ,respiratory tract diseases ,3. Good health ,medicine.anatomical_structure ,chemistry ,030220 oncology & carcinogenesis ,Immunology ,lcsh:Industrial medicine. Industrial hygiene ,medicine.symptom ,business ,Safety Research - Abstract
Background Lipopolysaccharide (LPS) contained in tobacco smoke and a variety of environmental and occupational dusts is a toxic agent causing lung inflammation characterized by migration of neutrophils and monocytes into alveoli. Although migration of inflammatory cells into alveoli of LPS-treated rats is well characterized, the dynamics of their accumulation in the perivascular space (PVS) leading to a perivascular inflammation (PVI) of pulmonary arteries is not well described. Methods Therefore, we investigated migration of neutrophils and monocytes into PVS in lungs of male Sprague-Dawley rats treated intratracheally with E. coli LPS and euthanized after 1, 6, 12, 24 and 36 hours. Control rats were treated with endotoxin-free saline. H&E stained slides were made and immunohistochemistry was performed using a monocyte marker and the chemokine Monocyte-Chemoattractant-Protein-1 (MCP-1). Computer-assisted microscopy was performed to count infiltrating cells. Results Surprisingly, the periarterial infiltration was not a constant finding in each animal although LPS-induced alveolitis was present. A clear tendency was observed that neutrophils were appearing in the PVS first within 6 hours after LPS application and were decreasing at later time points. In contrast, mononuclear cell infiltration was observed after 24 hours. In addition, MCP-1 expression was present in perivascular capillaries, arteries and the epithelium. Conclusion PVI might be a certain lung reaction pattern in the defense to infectious attacks.
- Published
- 2008
91. 121 Sub-suppressor dose of candesartan prevents perivascular inflammation and myocardial fibrosis, but not myocyte hypertrophy, in hypertensive hearts
- Author
-
H Kai
- Subjects
medicine.medical_specialty ,business.industry ,law.invention ,Candesartan ,law ,Internal medicine ,medicine ,Cardiology ,Perivascular inflammation ,Suppressor ,Myocardial fibrosis ,Myocyte hypertrophy ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Published
- 2003
92. INFLAMMATORY INTERACTIONS AND SECRETION IN CARDIAC REMODELING
- Author
-
Yang, Fanmuyi
- Subjects
- perivascular inflammation, pressure-overload, left ventricular hypertrophy, coronary remodeling, platelets, lymphocytes, granular secretion, Munc13-4, Medical Physiology
- Abstract
Heart failure contributes to nearly 60,000 deaths per year in the USA and is often caused by hypertension and preceded by the development of left ventricular hypertrophy (LVH). LVH is usually accompanied by intensive interstitial and perivascular fibrosis which may contribute to arrhythmogenic sudden cardiac death. Emerging evidence indicates that LV dysfunction in patients and animal models of cardiac hypertrophy is closely associated with perivascular inflammation. To investigate the role of perivascular inflammation in coronary artery remodeling and cardiac fibrosis during hypertrophic ventricular remodeling, we used a well-established mouse model of pressure-overload-induced LVH: transverse aortic constriction (TAC). Early perivascular inflammation was indicated by accumulation of macrophages and T lymphocytes 24 hours post-TAC and which peaked at day 7. Coronary luminal platelet deposition was observed along with macrophages and lymphocytes at day 3. Also, LV protein levels of VEGF and MCP-1 were significantly increased. Consistent with lymphocyte accumulation, cardiac expression of IL-10 mRNA was elevated. Furthermore, circulating platelet-leukocyte aggregates tended to be higher after TAC, compared to sham controls. Platelets have been shown to modulate perivascular inflammation and may facilitate leukocyte recruitment at sites of inflamed endothelium. Therefore, we investigated the impact of thrombocytopenia in the response to TAC. Immunodepletion of platelets decreased early perivascular accumulation of T lymphocytes and IL-10 mRNA expression, and altered subsequent coronary artery remodeling. The contribution of lymphocytes was examined in Rag1-/- mice, which displayed significantly more intimal hyperplasia and perivascular fibrosis compared to wild-type mice following TAC. Collectively, our studies support a role of early perivascular accumulation of platelets and T lymphocytes in pressure overload-induced inflammation which will contribute to long-term LV remodeling. One potential mechanism for inflammatory cells to modulate their environment and affect surrounding cells is through release of cargo stored in granules. To determine the contribution of granule release from inflammatory cells in the development of LVH, we used Unc13dJinx (Jinx) mice, which contain a single point mutation in Unc13d gene resulting in defects in Munc13-4. Munc13-4 is a limiting factor in vesicular priming and fusion during granule secretion. Therefore, Jinx mice have defects in degranulation of platelets, NK cells, cytotoxic T lymphocytes, neutrophils, mast and other cells. With the use of bone marrow transplantation, Jinx chimeric mice were created to determine whether the ability of hematopoietic cells to secrete granule contents affects the development of LVH. Wild-type mice (WT) that were transplanted with WT bone marrow (WT>WT) and WT mice that received Jinx bone marrow (Jinx>WT) developed LVH and a classic fetal reprogramming response early after TAC (7 days), but at later times (5 weeks), Jinx>WT mice failed to sustain the cardiac hypertrophic response observed in WT>WT mice. No difference in cardiac fibrosis was observed at early or late times. Repetitive injection of WT platelets or platelet releasate restored cardiac hypertrophy in Jinx>WT mice. These results suggest that sustained LVH in the setting of pressure overload depends on factor(s) secreted, likely from platelets. In conclusion, our studies demonstrate that platelets and lymphocytes are involved in early perivascular inflammation post-TAC, which may contribute to later remodeling in the setting of LVH. Factors released from hematopoietic cells, including platelets, in a Munc13-4-dependent manner are required to promote cardiac hypertrophy. These findings focus attention on modulating perivascular inflammation and targeting granule cargo release to prevent the development and consequences of LVH.
- Published
- 2012
93. Response of microvessels of the subcutaneous areolar tissue to argon laser irradiation
- Author
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V. I. Kozlov, G. M. Nikol'skaya, V. S. Barkovskii, and P. I. Saprykin
- Subjects
Pathology ,medicine.medical_specialty ,Materials science ,Argon ,chemistry.chemical_element ,General Medicine ,Blood flow ,Laser ,General Biochemistry, Genetics and Molecular Biology ,Microcirculation ,law.invention ,chemistry ,law ,medicine ,Perivascular inflammation ,sense organs ,Irradiation ,Areolar tissue ,Laser beams ,Biomedical engineering - Abstract
The effect of argon laser irradiation on the microvessels of the subcutaneous areolar tissue of the rabbit ear, mounted in a transparent chamber by Clark's method, was studied. The capillaries and venules, in which dysfunctional changes were found in the microcirculation, were most sensitive to argon laser irradiation. Besides destruction of the vessel walls and perivascular inflammation, active reorganization of the microcirculatory system and a redistribution of the blood flow were observed under the influence of the laser beam.
- Published
- 1978
94. Cutaneous Deposition of Immune Complexes in Chronic Serum Sickness of Mice Induced with Cationized or Unaltered Antigen
- Author
-
Steve A. Joselow, Mart Mannik, and Allen M. Gown
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Pathology ,medicine.medical_specialty ,Inflammation ,Antigen-Antibody Complex ,Immunofluorescence Microscopy ,Dermatology ,Biology ,Kidney ,Biochemistry ,Mice ,Serum Sickness ,Immune system ,Antigen ,medicine ,Animals ,Perivascular inflammation ,Antigens ,Molecular Biology ,Skin ,Cell Biology ,medicine.disease ,Immune complex ,Antibodies, Anti-Idiotypic ,Microscopy, Electron ,Proteinuria ,Immunoglobulin G ,Immune complex deposition ,Serum sickness ,Immunology ,Rabbits ,medicine.symptom - Abstract
We have previously shown that cationic proteins localize to the dermal-epidermal junction (DEJ) after i.v. injection in experimental animals. In the present studies, cationized rabbit IgG was used as antigen for induction of chronic serum sickness in C57BL/6J mice over a period of 4 weeks. The formation of immune deposits was examined by immunofluorescence microscopy at weekly intervals during chronic antigen administration and at 7 weeks from the initiation of studies. Chronic administration of the cationized antigen led to immune complex deposits at the DEJ, while administration of the same antigen in native form did not lead to these deposits. Junctional immune deposits increased with higher doses of cationized antigen and paralleled renal extraglomular deposition in intensity, persistence, and morphology. Mice given cationized antigen also demonstrated vascular immune complex deposits without complement, while mice given native antigen had complement deposits and developed perivascular inflammation. No inflammation or complement deposition was detected at the DEJ in either group. Charge properties of circulating antigens are important in determining tissue sites of immune complex deposition and inflammation. Circulating cationic antigens can lead to immune deposits at the DEJ.
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- 1985
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95. Endothelial dysfunction in adipose triglyceride lipase deficiency
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Schrammel, Astrid, Mussbacher, Marion, Wölkart, Gerald, Stessel, Heike, Pail, Karoline, Winkler, Sarah, Schweiger, Martina, Haemmerle, Guenter, Al Zoughbi, Wael, Höfler, Gerald, Lametschwandtner, Alois, Zechner, Rudolf, and Mayer, Bernd
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PVAT, perivascular adipose tissue ,PDI, protein disulfide isomerase ,XBP1, X-box-binding protein 1 ,Mac-2, galectin-3 ,Hsp90, heat shock protein 90 ,Perivascular inflammation ,Adipose triglyceride lipase ,PEG, polyethyleneglycol ,Mice ,IRE-1α, inostitol-requiring enzyme 1α ,Endothelial dysfunction ,HO-1, heme oxygenase-1 ,Mice, Knockout ,CPP, coronary perfusion pressure ,Endothelial NO synthase ,eNOS, endothelial nitric oxide synthase ,WAT, white adipose tissue ,MCP-1, monocyte chemotactic protein-1 ,NOX, NADPH oxidase ,TG, triacylglycerol ,TNFα, tumor necrosis factor α ,IL-6, interleukin 6 ,Adipose Tissue ,GAPDH, glyceraldehyde-3-phosphate dehydrogenase ,BK, bradykinin ,NLSDM, neutral lipid storage disease with myopathy ,pVASP, phosphorylated vasodilator-stimulated phosphoprotein ,Myocytes, Smooth Muscle ,PBS, phosphate-buffered saline ,DMEM, Dulbecco's Modified Eagle Medium ,Article ,Gene Expression Regulation, Enzymologic ,α-SMA, α-smooth muscle actin ,Organ Culture Techniques ,SOD, superoxide dismutase ,Animals ,Humans ,PPAR alpha ,Obesity ,Molecular Biology ,Triglycerides ,DEA/NO, 2,2-diethyl-1-nitroso-oxyhydrazine ,Heart Failure ,ATGL, adipose triglyceride lipase ,EDTA, ethylenediaminetetraacetic acid ,ACh, acetylcholine ,Lipase ,Cell Biology ,Vascular proteasome ,Lipid Metabolism ,WT, wild-type ,BIP, binding immunoglobulin protein ,Disease Models, Animal ,Oxidative Stress ,AKO, adipose triglyceride lipase knockout ,H&E, hematoxylin and eosin ,BSA, bovine serum albumin ,CL, chemiluminescence ,PPARα, peroxisome proliferator receptor α ,U 46619, 9,11-dideoxy-9α,11α-epoxy-methanoprostaglandin F2α ,CD31, cluster of differentiation 31 ,Nitric Oxide Synthase ,VASP, vasodilator-stimulated phosphoprotein - Abstract
Systemic knockout of adipose triglyceride lipase (ATGL), the pivotal enzyme of triglyceride lipolysis, results in a murine phenotype that is characterized by progredient cardiac steatosis and severe heart failure. Since cardiac and vascular dysfunction have been closely related in numerous studies we investigated endothelium-dependent and -independent vessel function of ATGL knockout mice. Aortic relaxation studies and Langendorff perfusion experiments of isolated hearts showed that ATGL knockout mice suffer from pronounced micro- and macrovascular endothelial dysfunction. Experiments with agonists directly targeting vascular smooth muscle cells revealed the functional integrity of the smooth muscle cell layer. Loss of vascular reactivity was restored ~ 50% upon treatment of ATGL knockout mice with the PPARα agonist Wy14,643, indicating that this phenomenon is partly a consequence of impaired cardiac contractility. Biochemical analysis revealed that aortic endothelial NO synthase expression and activity were significantly reduced in ATGL deficiency. Enzyme activity was fully restored in ATGL mice treated with the PPARα agonist. Biochemical analysis of perivascular adipose tissue demonstrated that ATGL knockout mice suffer from perivascular inflammatory oxidative stress which occurs independent of cardiac dysfunction and might contribute to vascular defects. Our results reveal a hitherto unrecognized link between disturbed lipid metabolism, obesity and cardiovascular disease., Graphical abstract, Highlights • AKO mice suffer from severe micro- and macrovascular endothelial dysfunction. • Aortic eNOS protein is downregulated in ATGL deficiency due to enhanced proteasomal degradation. • PVAT of AKO mice exhibits characteristics of chronic inflammatory oxidative stress. • At least two independent mechanisms are involved in the endothelial defect.
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96. Abnormalities in the Macroscopically Normal White Matter in Cases of Mild or Spinal Multiple Sclerosis (MS)
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I. V. Allen, R. Anderson, and G. Glover
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White matter ,Pathology ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Multiple sclerosis ,Medicine ,Perivascular inflammation ,business ,medicine.disease - Abstract
In a study of a series of mild and spinal varieties of multiple sclerosis the following histological changes have been found in the macroscopically normal white matter: 1. Marked astrocytic proliferation. 2. Some sclerosis of blood vessels. 3. Some perivascular inflammation. 4. Occasional unsuspected demyelination.
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- 1981
97. Extensive alopecia areata. Results of treatment with 3% topical minoxidil
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Richard E. Ranchoff, Willard D. Steck, Wilma F. Bergfeld, and Steven J. Subichin
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Alopecia Areata ,Administration, Topical ,Diastole ,Placebo ,Double-Blind Method ,Biopsy ,medicine ,Perivascular inflammation ,Humans ,skin and connective tissue diseases ,Child ,Topical minoxidil ,Clinical Trials as Topic ,integumentary system ,medicine.diagnostic_test ,business.industry ,General Medicine ,Alopecia areata ,Middle Aged ,medicine.disease ,Dermatology ,Clinical trial ,Minoxidil ,Female ,business ,medicine.drug - Abstract
A 3% topical minoxidil solution was used to treat 31 normotensive persons (13 male, 18 female) with extensive alopecia areata. After 15 months, three patients (14%) had 75%-100% regrowth, 13 (59%) had some form of regrowth, and nine (41%) had no regrowth. In the initial three-month double-blind portion of the study, minoxidil was not shown to be more effective than placebo. Biopsy specimens from eight patients who underwent biopsy prior to treatment, after three months, and posttreatment showed no significant change in peribulbar or perivascular inflammation. Prominent, new anagen follicles were observed. The 3% topical minoxidil was generally well tolerated and skin irritation was minimal. Blood pressure monitoring revealed no significant changes in diastolic or systolic pressures. Minoxidil is a relatively safe treatment for extensive alopecia areata and may be effective in the treatment of some cases of recalcitrant disease.
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- 1989
98. Multiple evanescent white dot syndrome
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M. Madison Slusher and Richard G. Weaver
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Adult ,Male ,medicine.medical_specialty ,genetic structures ,Multiple evanescent white dot syndrome ,Eye Diseases ,Fundus Oculi ,Fundus (eye) ,Ophthalmology ,medicine ,Electroretinography ,Perivascular inflammation ,Humans ,Macula Lutea ,Fluorescein Angiography ,Pigment Epithelium of Eye ,Scotoma ,Retina ,medicine.diagnostic_test ,business.industry ,General Medicine ,Fluorescein angiography ,medicine.disease ,eye diseases ,Staining ,medicine.anatomical_structure ,Female ,sense organs ,business ,Erg ,Optic disc - Abstract
Three patients had documented fundus changes conforming to those of the recently described multiple evanescent white dot (MEWD) syndrome. All three patients were unilaterally affected with variously sized, soft, single, and coalescent white lesions at the level of the RPE and the deep retina. Fluorescein angiography demonstrated early staining and hyperfluorescence of the white dots and delayed staining around the optic disc. Some degree of optic disc edema could be seen in all three eyes, two of which had corresponding field defects. In all three eyes, characteristic “stippling,” or granularity, of the affected macula developed rapidly and vitreal cells were observed. One eye had signs of previous perivascular inflammation. ERG studies performed on one patient indicated a reduction in the a-wave and depression of the ERP, findings that correlated with the clinical observations of RPE affectation. RETINA 8:132-135, 1988
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- 1988
99. Histopathological studies with reference to chronic cadmium acetate intoxication in kidneys of squirrels
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R. K. Mithal
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Male ,Pathology ,medicine.medical_specialty ,Cadmium Poisoning ,Necrosis ,Tubular cell ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Sciuridae ,Kidney weight ,medicine.disease ,Kidney ,Adipose capsule of kidney ,Cloudy swelling ,chemistry.chemical_compound ,chemistry ,Chronic Disease ,medicine ,Perivascular inflammation ,Animals ,Female ,medicine.symptom ,Infiltration (medical) ,Cadmium acetate - Abstract
Histopathological alterations in kidneys have been studied in squirrels with repeated intraperitoneal injections of cadmium acetate at a dose of 1.0 mg Cd/Kg of body weight. Cloudy swelling, necrosis, denudation and destruction of tubular epithelium, focal aggregates of inflammatory cells, perivascular inflammation by chronic inflammatory cells and perinephric haemorrhage with infiltration by phagocytes containing haemosidirin were noticed after different exposure intervals. Squirrels revealed significant increase in body weight and kidney weight (P
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- 1980
100. Effects of opiate dependence through different administration routes on pulmonary inflammation and its severity
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Mohammad Masoomi, Ebrahim Abasi, Reza Malekpoor, Marzieh Tajoddini, and Gholamabbas Mohammadi
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medicine.medical_specialty ,Pathology ,Inhalation ,Opiate Dependence ,Naloxone ,business.industry ,Pulmonary inflammation ,Inflammation ,macromolecular substances ,General Medicine ,(+)-Naloxone ,Gastroenterology ,Kowsar ,pulmonary Inflammation ,Internal medicine ,medicine ,Perivascular inflammation ,medicine.symptom ,Opiate ,business ,Opiate dependence ,Research Article - Abstract
Background Serious health problems and socioeconomic consequences of the illicit use of opiates have been proved in both developed and developing societies Objectives We aimed to evaluate" The effects of opiate addiction through different administration routes on pulmonary inflammation and its severity." Materials and Methods Our experiments were performed on eighteen adult male Syrian golden hamsters which were allocated to one of the three groups (n = 6): control group which did not receive opiate; the first study group were administered oral opiate via stomach tube; and another study group were administered inhaled opiate. After four weeks, all hamsters were anesthetized with diethyl ether and their lung tissues were isolated for pathological assessment. Results Severe perivascular inflammation was detected in 33.3% of the samples with oral opiate dependence and 20% of the cases addicted to opiate through inhalation. Also, severe peribronchial inflammation was observed in only 20% of the samples addicted to inhaled opiate and was not found in the other groups. No significant differences were found in the severity of perivascular and peribronchial inflammation across the three groups. Although the mean of total inflammation scale in the subjects with oral opiate dependence (3.00 ± 1.79) was numerically higher than that in the inhaled dependence group (1.40 ± 2.60) and the controls (2.25 ± 1.26), this difference was not statistically significant. Conclusions Administration did not influence the appearance or severity of pulmonary inflammation in animal models addicted to opiate.
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